REBIRTH partner institutions or: joining forces for success
Medizinische Hochschule Hannover (Hannover Medical School)
The Hannover Medical School (Medizinische Hochschule Hannover, MHH) is one of leading universities in research, patient care and teaching. With its concentrated support of specialised research areas, it is one of the finest university clinics in the country, and Germany's only institution of higher education devoted exclusively to medicine. Founded in 1965, MHH is also the only medical university (faculty) in Germany operating under a true ‘Integration Model’. Under this model, the clinical and diagnostic laboratory services of a large university hospital and medical university are run under one administrative structure with a unified budget.
Every year, more than 54,000 inpatients and well over 330,000 outpatients are treated at the MHH, which provides a full range of treatment and care of the highest quality. In no other university clinic in Germany are patients with such severe conditions treated as they are in the 18 medical centres and 75 departments on the MHH campus. The MHH is also a pioneer in transplant medicine and is one of the world's leading transplant centres. 400 to 500 organ transplants are performed yearly, more than anywhere else in Germany. The MHH is one of the world leaders in lung transplants and ECMO treatment. In addition, 140 to 170 bone marrow and blood stem cell transplants are handled every year. Moreover, the MHH has a leading position in cochlear implants, electronic inner ear stimulating devices. To date 5,000 patients (500 a year) have been fitted with one of these devices, enabling them to hear again – or for the first time.
The MHH is also a leader in research, as is clear from the number of interdisciplinary projects and the volume of funding acquired: in 2010, this amounted to 84.6 million euro. This success was made possible by the more than 1,600 scientists and nearly 30,000 square meters of laboratory space at the MHH. Among the research institutions at the MHH are the Cluster of Excellence REBIRTH for regenerative medicine, the Integrated Research and Treatment Centre Transplantation (IFB-Tx), 28 research projects within the 7 Framework Programme of the European Union, seven DFG Collaborative Research Centres (CRC), four DFG Research Groups, one DFG Priority Programme, one European Research Training Programme, and hundreds of other research projects. Furthermore, the Federal Government is currently establishing six German Centres for Health Research to pool research into a number of particularly important common diseases. Researchers of the MHH will contribute to two of these centres: the German Centre for Infection Research and the German Centre for Lung Research.
The major research areas of the MHH are Infection, Immunity and Inflammation; Biomedical Engineering and Implants; Transplantation and Stem Cell Research. The MHH is a leader in the research of Infection and Immunity, cooperating with the Helmholtz Centre for Infection Research in Braunschweig. Both are members of TRAIN, a cross-disciplinary alliance of university and non-university research institutes in the Hannover/Braunschweig area, funded by the Ministry of Science and Culture of the German State of Lower Saxony. Within TRAIN, know-how and infrastructure are being pooled, so as to accelerate the transfer of new candidate drugs and vaccines from bench to bedside. Interdisciplinary cooperation is the major aim of the MHH - within and beyond the borders of the Campus - in the Clinic and in Research.
The Excellence Initiative of the federal and state governments recognised the exceptional research potential present at the MHH: The Cluster of Excellence REBIRTH for Regenerative Medicine is based on the work of outstanding research groups, particularly those dedicated to stem cell research, to engineering of heart, lung, liver and blood tissue, and to biohybrid devices. In 2008, more than 110 scientists started working in a new facility, the Hans Borst Research Centre for Heart and Stem Cell Research, which is located directly next to the Transplant Research Centre.
With its Integrated Research and Treatment Centre Transplantation (IFB-Tx) the MHH has been strengthened in its role as the leading institution for transplant research, which, with up to 50 million euro funding since 2007, has made possible more rapid clinical application of research results.
At MHH, there are about 143 positions at the senior academic level (full, associate, assistant professors) and about 1,645 permanent positions for medical doctors and scientists.
The MHH is internationally renowned for excellence in patient care, research and teaching. There is great demand by students, physicians and scientists from all over the world to come to Hannover to study, work and conduct research. International cooperative agreements and networks are constantly being expanded with other universities and clinics worldwide. Furthermore, the MHH organises internships and foreign study semesters for its students. People from more than 40 countries study, work and do research at the MHH, which is thus one of the most international workplaces in the capital of Lower Saxony.
More than 3,000 students are currently enrolled at the MHH: in medicine or dentistry as undergraduates or in a doctoral or other advanced degree programme. In the winter semester 2005/2006, a new medical curriculum was established: "HannibaL", an acronym for the Hannover Medical School's integrated, professionally oriented, adaptive course of study. All coursework focuses on practical application. From the very first week, students are in direct contact with patients. Each year, three tenweek modules covering the same subject matter are offered in parallel (from October to December, January to March, and April to July). The year's 270 students are assigned to three groups, so that only 90 are enrolled in a module at a given time.
In 2003, the MHH founded its Hannover Biomedical Research School (HBRS) to recruit and keep the best young scientists. This graduate school represents an “umbrella organisation” for existing and future structured postgraduate programmes – mainly PhD programmes and Research Training Groups (GKs). It coordinates teaching and ensures excellent training in high quality research laboratories, furthers motivation, and actively encourages integration and interdisciplinary exchange between students and young researchers from both medical and life science backgrounds. A joint HBRS curriculum was established in 2003, and the excellent quality of the various training programmes was confirmed in 2005, when the DAAD acclaimed the MHH's MD/PhD programme Molecular Medicine as “Best-practise program”. In addition, HBRS was successful in the national Excellence Initiative as well.
The MHH is the best provider of childcare arrangements among all universities in Germany, with places for 375 boys and girls between the ages of eight months (150) and ten years, and this service is constantly being expanded. Childcare is also available in emergency situations. The MHH Mentoring Programme for Women was established in 2004 to help women structure and plan their scientific careers. In 2005, the MHH underwent the audit by the Hertie Foundation “Family Friendly University” that confirmed the quality of its family orientated services, and was successfully re-audited in 2008.
The MHH provides occupational training for nearly 500 young people in its five schools of healthcare professions. Furthermore, up to 60 apprentices receive training at the MHH to learn a wide range of trades regulated by the medical association, such as physician's assistant, medical data specialist, animal handler, dental technician and more.
The German Federation started a programme to support “Voluntary Services” in 2008. In 2011 the MHH joint this programme and initiated “Voluntary Scientific Year” supported by the Clusters of Excellence REBIRTH and QUEST as well as the Graduate School HBRS. About 40 High-School graduates will start a scientific internship in one of the MHH‘s or Leibniz University Hannover laboratories in September 2011.
For further information on the MHH please visit its website.
Leibniz University of Hannover (LUH)
“Shaping the future with knowledge” – this is the guiding principle of Leibniz Universität Hannover. Founded in 1831 as a trading school in the kingdom of Hannover, the university today comprises nine faculties and one Leibniz Research School with the rank of a faculty. The study programmes cover engineering, natural sciences, landscape science, architecture, economics, law, social sciences, and the humanities. Leibniz Universität Hannover offers more than 170 fulltime and part-time study programmes for degrees at various levels.
Faculty of Architecture and Landscape Sciences
Faculty of Civil Engineering and Geodetic Science Faculty of Economics and Management
Faculty of Electrical Engineering and Computer Science
Faculty of Humanities
Faculty of Law
Faculty of Mathematics and Physics
Faculty of Mechanical Engineering
Faculty of Natural Sciences
QUEST Leibniz Research School
The academic staff includes 312 professors who are in charge of the academic teaching of 21,000 students, 12 % of whom are international students who have received their certificate for university entrance in a foreign country. The proportion of female students acquiring a degree at Leibniz Universität in the winter term of 2009/10 was 43 %, whereas the share of female graduates was 52 %. Overall, 34 % of the 339 dissertations for a doctoral degree in 2010 were submitted by women. Leibniz Universität considers gender equality a central aspect for the future development of science. Therefore, the appointment of female professors is at the core of the university’s research strategy. In 2010 one third of the 28 newly appointed professors were female. In total, 56 of the 312 professors (18 %) are female. Moreover, there were 2,356 researchers at Leibniz Universität in 2010, of whom 692 (31 %) were women.
Leibniz Universität enjoys a high level of international recognition and has a strong scientific profile, most notably in the fields of mechanical engineering and physics. This is emphasised by the successful establishment of not only “QUEST – Centre for Quantum Engineering and Space-Time Research” as a Centre of Excellence during the first period of the national Excellence Initiative by the German Federal and State Governments, but also by participation in the cluster of excellence “REBIRTH – From Regenerative Biology to Reconstructive Therapy” that is situated at the Hannover Medical School (MHH). In the current application phase of the second period of the Excellence Initiative, Leibniz Universität is, besides the MHH and the University of Oldenburg, one of the applicants involved in the cluster “Hearing4all - Models, Technology and Solutions for Diagnostics, Restoration and Support of Hearing”, which has been asked to submit a full proposal. As part of the Niedersächsische Technische Hochschule (NTH), an alliance of three neighbouring universities in Braunschweig, Clausthal and Hannover covering the fields of engineering, natural sciences, mathematics and architecture, Leibniz Universität, as the university in charge, has been requested to partake in the application of the Graduate School “PhDCube: NTH School of Engineering Sciences” in the context of the Excellence Initiative.
Scientists of Leibniz Universität coordinate three Collaborative Research Centres (CRC) financed by the German Research Foundation (DFG), and participate in six additional CRC/Transregios. Moreover, Leibniz Universität hosts six Research Units (RU) and four Research Training Groups (RTG), and coordinates two Priority Programmes (PP) of the DFG. The coordinators of five research projects within the 7th Framework Programme of the European Union are scientists of Leibniz Universität and three professors have received an ERC-starting grant in 2011. Leibniz Universität is involved in 13 cooperative research projects financed by the Federal Ministries of Education and Research, and Environment with funding of more than 500,000 euros each.
Leibniz Universität hosts two further graduate programmes related to the Cluster of Excellence QUEST: (1) the International Max Planck Research School on Gravitational Wave Astronomy, a collaboration between Max Planck Institute for Gravitational Physics (Albert Einstein Institute), Leibniz Universität and Laser Zentrum Hannover, (2) the Hannover School for Laser, Optics and Space-Time Research (HALOSTAR), a PhD programme coordinated by Leibniz Universität and financed by the State of Lower Saxony. The annual revenue in third-party funding reached 88.6 Million euro in 2009. In total, Leibniz Universität’s budget in 2010 was approximately 384 Million euro.
In 2009, the Laboratory for Nano and Quantum Engineering (LNQE), one of the five Research Centres (RC) at Leibniz Universität, inaugurated a 14 Million Euro research building. A second research building for the “Centre of Biomolecular Drug Research” was granted in 2010. Their constructions were financed by the State of Lower Saxony and by federal funds. In 2011, Leibniz Universität has successfully applied for three further research buildings: the Hannover Institute of Technology (HITec), a supercomputer for the North-German Supercomputing Alliance (Norddeutscher Verbund fur Hoch- und Hochstleistungsrechner, HLRN), and a centre for testing and control of components for offshore wind farms.
Besides the third-party funded research programmes, Leibniz Universität has implemented a research strategy to promote interdisciplinary research and competitive priority research areas. With an innovative organisational structure it enables scientists to pursue cutting-edge research across traditional subjects and faculty boundaries. At the first developmental stage of the strategy, individual working groups formed Research Initiatives (RI) to investigate clearly formulated and substantial research topics with an interdisciplinary scope. Currently, there are 13 RIs involving scientists from a range of disciplines covering diverse topics such as the transformation of energy systems, future of the internet, geo-informatics and optical technologies. At the second stage, the research activities carried out in Research Centres (RC) are characterised by a considerable degree of international and scientific visibility. RCs regularly undergo an external review process and collaborate with external research institutions. Five RCs have been established since 2007: Centre for Garden Art and Landscape Architecture, Laboratory of Nano and Quantum Engineering, Hannover Centre for Mechatronics, Centre for Biomolecular Drug Research, Centre for Solid State Chemistry and New Materials. The university management partly supports these centres financially. At the top stage of the organisational structure promoting interdisciplinary research at Leibniz Universität, Leibniz Research Schools provide a flexible structure for cross-faculty research at highest international level. The Cluster of Excellence QUEST became the first Leibniz Research School in 2009.
Leibniz Universität cooperates with several scientific institutions and organisations such as the Fraunhofer Society with the establishment of the Institute for Wind Energy and Energy System Technology (IWES). IWES and Leibniz Universität are members of a consortium which has applied for a cluster formed by business and science in the Leading-Edge Cluster Competition of the Federal Ministry of Education and Research. This consortium named WindPowerCluster has been asked to submit a full proposal in autumn 2011.
For further information on the LUH please visit its website.
Fraunhofer Institute of Toxicology and Experimental Medicine, Hannover (ITEM)
The Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM) is an institution of the Fraunhofer Society for the Advancement of Applied Research (FhG). The spectrum of research and development activities includes preclinical/clinical pharmacological research and development, allergy and asthma research, and investigations into tissue and environmental toxicology and consumer protection, as well as the testing and registration of chemicals, biocides and pesticides. As a member of the Fraunhofer Society with its focus on translational research, ITEM generates more than 50 % of its budget from industrial contacts. ITEM’s priority area of interest is diseases and disorders of the respiratory tract, and it has established a unique platform for molecular toxicology (with approved laboratories). This includes animal experiments using high-performance imaging techniques, a cell processing laboratory that works to good manufacturing practice (GMP) standards, and a clinical unit that is able to apply GMP in pulmonology. The ITEM has also collaborated successfully with the MHH, the LUH and the HZI for many years.
For further information on the ITEM please visit its website.
Helmholtz Centre for Infection Research, Braunschweig (HZI)
The Helmholtz Centre for Infection Research (HZI) is a non university research institution with more than 600 staff. An important player in the Helmholtz Association, the HZI has placed its scientific focus on infection research. The main theme around which the participating researchers’ work revolves is the complex interplay between infection pathogens and the immune system. There are numerous successful research ties with MHH, especially with all of its present collaborative research centres (SFBs). The HZI’s involvement is quite crucial for the fields of immunology and cell biology and for associated technology platforms such as genomics, proteomics, mouse genetics, development of good manufacturing practice (GMP) and the production of proteins, cell and gene therapy products, and in vivo imaging. The HZI and the MHH receive joint funding from the DFG, the BMBF, the EU, and the Bill and Melinda Gates Foundation.
For further information on the HZI please visit its website.
Institute of Farm Animal Genetics, Friedrich-Loeffler-Institute (FLI), Mariensee
The Friedrich-Loeffler-Institute (FLI), Germany’s Federal Research Institute of Animal Health, is an independent higher federal authority run under the aegis of the German Federal Ministry of Food and Agriculture (BMEL).The main task is to promote and monitor the health of farm animals and protecting people from infections that can be transmitted from animals to humans (zoonoses).The FLI has 11 institutes on five different sites. The Mariensee site (approximately 30 km northwest of Hannover) is home to the Institute of Farm Animal Genetics.
Prominent research projects at the Mariensee laboratories with connection to Rebirth relate to the production and the characterization of transgenic pigs for xenotransplantation research, to produce large animal models, or for studies on cell reprogramming by somatic cell nuclear transfer based on cloning. Another important issue is the development of suitable culture systems for maintenance of pluripotent stem cells mainly in pigs. The Institute of Farm Animal Genetics has enjoyed long and successful cooperation with MHH (in the form of a collaborative research centre). The Institute has unique expertise relating to large-animal models and tissue regeneration. These aspects are of great importance for the development of innovative approaches to cell therapy and tissue engineering, and their comparative evaluation.
For further information on the FLI please visit the website.
Laser Zentrum Hannover e.V. (LZH)
On June 20, 1986 the Laser Zentrum Hannover e.V. (LZH) was founded under the patronage of the German State Ministry of Trade, Industry, Technology, and Transportation in Lower Saxony. The main task of the LZH is to support applied research in laser technology on a non-profit basis. The LZH is involved in:
- R&D projects in the field of laser development and laser applications
- Technical and scientific consulting to link research and practice
- Industry-oriented training of experts for applying and operating laser systems
Through the close cooperation between production engineers, material scientists, and physicists the scientists of the LZH find interdisciplinary solutions for all fields of laser applications.
For further information on the LZH please visit its website.
Max Planck Institute for Molecular Biomedicine, Münster (MPI)
More than 150 scientists from over 15 countries are engaged in research at the Max Planck Institute for Molecular Biomedicine (MPI). The institute, founded in 2001, comprises three departments:
• Vascular cell biology;
• Cell and developmental biology; and
• Tissue biology and morphogenesis.
One of the MPI’s chief research focuses is on the molecular biology of pluripotent stem cells and germline development. This involves strategies for reprogramming somatic cells into a pluripotent state by means of somatic cell nucleus transfer or other techniques such as cell fusion. One of the main aims is to discover factors and complexes that modify chromatin and histones during the reprogramming process. A further area of expertise consists in the differentiation of germ cells from pluripotent cells, as with the in vitro production of oocytes (egg cells) from ES cells. Many national and international collaborations have been firmly established, including those with the Institute of Farm Animal Genetics Mariensee and MHH.
For more information on the MPI please visit the website.
University of Veterinary Medicine Hannover, Foundation (TiHo)
The University of Veterinary Medicine Hannover, Foundation (TiHo) is run under the auspices of a public foundation. Founded in 1778, today it is the oldest independent college of veterinary medicine in Germany and numbers among the most renowned veterinary educational institutions worldwide. The TiHo has close ties with both the LUH and MHH. The participating departments combine clinical diagnostics and therapeutic procedures with innovative research in biomedicine and biomedical engineering. In this connection, various interdisciplinary collaborative ventures between clinical research and technically oriented fields have emerged. The TiHo has unique expertise in diagnostic and therapy models, which are of great importance as models for diseases and disorders in humans. The Small Animal Clinic, for example, is able to integrate both in vivo and in vitro approaches, utilizing its know-how in different molecular methods, cell cultures and investigative techniques (relating to animal breeding and surgical procedures), the use of special equipment (such as micro-CT scanners and fluorescence microscopes) and multiple clinical studies.
For further information on the TiHO please visit its website.
|Department of Cardiovascular Surgery, Osaka University Graduate School of Medicine||2-2 Yamadaola Suita, Osaka 565-0871, Japan|
|Department of Biotechnology & Food Engineering, Technion-Israel Institute of Technology||Technion City, Haifa 32000, Israel|
|Harvard Medical School, Children's Hospital Boston||300 Longwood Avenue, Karp B, Boston, Massachusetts, USA|
|Cincinnati Children's Hospital Medical Center||3333 Burnet Ave, MLC7020, Cincinnati, OH 45229-3039, USA|
|UCL Institute of Child Health, Modecular Immunology Unit||30 Guilford Street, London WC1N 1EH, UK|
|Department of Immunohematology and Blood Transfusion, Leiden University Medical Center||Albinusdreef 2, 2333 ZA Leiden, Netherlands|
|Neil Young, National Institute of Health (NIH)||9000 Rockville Pike, Bethesda, Maryland 20892, USA|
|Paul-Ehrlich Institute||Paul-Ehrlich-Str. 51-59, 63225 Langen, Germany|
|Europäisches Institut für Forschung und Entwicklung von Transplantationsstrategien (EUFETS) GmbH||Vollmersbachstr. 66, 55743 Idar-Oberstein, Germany|
|PlasmidFactory GmbH & Co. KG||Meisenstr. 96 33607 Bielefeld, Germany|
|TET Systems GmbH & Co. KG, Leadership In Controlled Gene Expressions||Im Neuenheimer Feld 582, 69120 Heidelberg, Germany|
|Stemcell Technologies||Miniparc Polytec, 60 Rue des Berges, 38000 Genoble, France|
|Rentschler||Erwin-Rentschler-Str. 21, 88471 Laupheim, Germany|
|Miltenyi||Friedrich-Ebert-Str. 68, 51429 Bergisch Gladbach, Germany|
|Sartorius||Stedim Biotech GmbH, August-Spindler-Str. 11, 37079, Germany|
|Roche Diagnostics Deutschland GmbH||Sandhofer Str. 116, 68305 Mannheim, Germany|
|Chinese Academy of Sciences, Guangzhou Institute of Biomedicine & Health||No. 190, Kai-Yuan Avenue, Guangzhou Science Park, China|
|Rodos Biotarget GmbH||Feodor-Lynen-Str. 23, 30625 , Germany|
|Kinaris Biomedicals GmbH||Chemnitzer Str. 46b, 081187 Dresden, Germany|
|corlife GbR||Feodor-Lynen-Str. 22, 30625 Hannover, Germany|
|Particular GmbH||Hollerithallee 8|
30419 Hannover, Germany
|InSCREENeX GmbH||Inhoffenstraße 7 | 38124 Braunschweig, Germany|