Senescence in Vascular Regeneration

Objectives

Our goal is to prove that there is a causal relationship between senescence and the physiological degeneration of endothelial and vascular function in vitro and in vivo. As the signaling pathways that are responsible for the induction of senescence in endothelial cells are not fully unravelled yet, we further intend to investigate how senescence is induced in endothelial cells. 

Our long term goals are: 

  • To prove the causal relationship between senescence and endothelial dysfunction and cardio-vascular disease. 
  • To show that strategies that interfere with senescence lead to endothelial and vascular regeneration. 
  • To prove that inflammatory processes such as periodontitis trigger senescence and thereby lead to endothelial dysfunction and cardiovascular disease. 

Research Focus

Accumulating evidence points towards an important role of senescence in aging, degeneration and for the response to certain injuries in vivo. The hypothesis is that senescence exhausts the reserves of somatic cells that are involved in cell-division and thereby cell-renewal - cellular skills indispensable for repair, integrity and regeneration. So far, no direct link between the presence of senescent cells and the onset of cardiovascular disease has been shown. Nevertheless, there are several observations suggesting senescence as mediator of or even the cause of cardiovascular complications. We intent to answer the question, whether known signaling pathways leading to cellular senescence play a role in the development of endothelial dysfunction and lead to cardiovascular disease. Overcoming senescence should lead to increased regenerative potential and result in improved endothelial and vascular function. 

During the first funding period of the excellence cluster, we showed in cooperation with other REBIRTH groups that implementing regular physical exercise in sedentary middle aged man is associated with a rejuvenation of circulating leukocytes (significantly increased telomere length, telomerase activity and reduced p16INK4a expression) and may thereby improve their regenerative capacity. This was hampered in individuals with cardiovascular risk factors or suffering from severe periodontitis. Based on this observation and evidence from the literature that inflammatory processes induce senescence, we hypothesize that activation of senescence pathways could be the potential link between the inflammatory reactions induced by a chronic inflammatory process such as periodontitis and cardiovascular alterations. Exploration of this relationship is part of a DFG project that is linked to this REBIRTH project.  

Collaborations

  •  T. Thum, REBIRTH Unit miRNA in Myocardial Regeneration, MHH
  • A. Hilfiker-Kleiner, REBIRTH Unit Endogenous Regeneration Mechanisms of the Heart, MHH 
  • A. Haverich, Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), MHH
  • M. Stiesch, Clinic for Dental Prosthetics , MHH 
  • U. Tegtbur, Sports Medicine, MHH
  • R. Schmitt and B. Schmidt, Clinic for Nephrology, MHH 
  • C. S. Falk, Transplantation Immunology, IFB-Tx, MHH 

Publications

2013 - ongoing

2018

Borchert-Morlins B, Memaran N, Sauer M, Maecker-Kolhoff B, Sykora KW, Blote R, Bauer E, Schmidt BMW, Melk A, Beier R. Cardiovascular risk factors and subclinical organ damage after hematopoietic stem cell transplantation in pediatric age. Bone Marrow Transplant. 2018.

Lerch C, Shroff R, Wan M, Rees L, Aitkenhead H, Kaplan Bulut I, Thurn D, Karabay Bayazit A, Niemirska A, Canpolat N, Duzova A, Azukaitis K, Yilmaz E, Yalcinkaya F, Harambat J, Kiyak A, Alpay H, Habbig S, Zaloszyc A, Soylemezoglu O, Candan C, Rosales A, Melk A, Querfeld U, Leifheit-Nestler M, Sander A, Schaefer F, Haffner D, consortium Cs, group EC-Mw. Effects of nutritional vitamin D supplementation on markers of bone and mineral metabolism in children with chronic kidney disease. Nephrol Dial Transplant. 2018.

Schmidt BMW, Sugianto RI, Thurn D, Azukaitis K, Bayazit AK, Canpolat N, Eroglu AG, Caliskan S, Doyon A, Duzova A, Karagoz T, Anarat A, Deveci M, Mir S, Ranchin B, Shroff R, Baskin E, Litwin M, Ozcakar ZB, Buscher R, Soylemezoglu O, Dusek J, Kemper MJ, Matteucci MC, Habbig S, Laube G, Wuhl E, Querfeld U, Sander A, Schaefer F, Melk A, Consortium CS. Early Effects of Renal Replacement Therapy on Cardiovascular Comorbidity in Children With End-Stage Kidney Disease: Findings From the 4C-T Study. Transplantation. 2018;102(3):484-92.

Wernicke K, Zeissler S, Mooren FC, Frech T, Hellmann S, Stiesch M, Grischke J, Linnenweber S, Schmidt B, Menne J, Melk A, Bauer P, Hillebrecht A, Eberhard J. Probing depth is an independent risk factor for HbA1c levels in diabetic patients under physical training: a cross-sectional pilot-study. Bmc Oral Health. 2018;18.

2017

Bhayana S, Baisantry A, Kraemer TD, Wrede C, Hegermann J, Brasen JH, Bockmeyer C, Ulrich Becker J, Ochs M, Gwinner W, Haller H, Melk A, Schmitt R. Autophagy in kidney transplants of sirolimus treated recipients. J Nephropathol. 2017;6(2):90-6.

Borchert-Morlins B, Thurn D, Schmidt BMW, Buscher AK, Oh J, Kier T, Bauer E, Baig S, Kanzelmeyer N, Kemper MJ, Buscher R, Melk A. Factors associated with cardiovascular target organ damage in children after renal transplantation. Pediatr Nephrol. 2017;32(11):2143-54.

Harambat J, Kunzmann K, Azukaitis K, Bayazit AK, Canpolat N, Doyon A, Duzova A, Niemirska A, Sozeri B, Thurn-Valsassina D, Anarat A, Bessenay L, Candan C, Peco-Antic A, Yilmaz A, Tschumi S, Testa S, Jankauskiene A, Erdogan H, Rosales A, Alpay H, Lugani F, Arbeiter K, Mencarelli F, Kiyak A, Donmez O, Drozdz D, Melk A, Querfeld U, Schaefer F, Consortium CS. Metabolic acidosis is common and associates with disease progression in children with chronic kidney disease. Kidney Int. 2017;92(6):1507-14.

Lipska-Zietkiewicz BS, Gellermann J, Boyer O, Gribouval O, Zietkiewicz S, Kari JA, Shalaby MA, Ozaltin F, Dusek J, Melk A, Bayazit AK, Massella L, Hyla-Klekot L, Habbig S, Godron A, Szczepanska M, Bienias B, Drozdz D, Odeh R, Jarmuzek W, Zachwieja K, Trautmann A, Antignac C, Schaefer F, PodoNet C. Low renal but high extrarenal phenotype variability in Schimke immuno-osseous dysplasia. PLoS One. 2017;12(8):e0180926.

McLin VA, Allen U, Boyer O, Bucuvalas J, Colledan M, Cuturi MC, d'Antiga L, Debray D, Dezsofi A, Goyet JV, Dhawan A, Durmaz O, Falk C, Feng S, Fischler B, Franchi-Abella S, Frauca E, Ganschow R, Gottschalk S, Hadzic N, Hierro L, Horslen S, Hubscher S, Karam V, Kelly D, Maecker-Kolhoff B, Mazariegos G, McKiernan P, Melk A, Nobili V, Ozgenc F, Reding R, Sciveres M, Sharif K, Socha P, Toso C, Vajro P, Verma A, Wildhaber BE, Baumann U. Early and Late Factors Impacting Patient and Graft Outcome in Pediatric Liver Transplantation: Summary of an ESPGHAN Monothematic Conference. J Pediatr Gastroenterol Nutr. 2017;65(3):e53-e9.

Schaefer F, Doyon A, Azukaitis K, Bayazit A, Canpolat N, Duzova A, Niemirska A, Sozeri B, Thurn D, Anarat A, Ranchin B, Litwin M, Caliskan S, Candan C, Baskin E, Yilmaz E, Mir S, Kirchner M, Sander A, Haffner D, Melk A, Wuhl E, Shroff R, Querfeld U, Consortium CS. Cardiovascular Phenotypes in Children with CKD: The 4C Study. Clin J Am Soc Nephrol. 2017;12(1):19-28.

Schauerte C, Hubner A, Rong S, Wang S, Shushakova N, Mengel M, Dettling A, Bang C, Scherf K, Koelling M, Melk A, Haller H, Thum T, Lorenzen JM. Antagonism of profibrotic microRNA-21 improves outcome of murine chronic renal allograft dysfunction. Kidney Int. 2017;92(3):646-56.

Schmitt R, Melk A. Molecular mechanisms of renal aging. Kidney Int. 2017;92(3):569-79.

Trautmann A, Schnaidt S, Lipska-Zietkiewicz BS, Bodria M, Ozaltin F, Emma F, Anarat A, Melk A, Azocar M, Oh J, Saeed B, Gheisari A, Caliskan S, Gellermann J, Higuita LMS, Jankauskiene A, Drozdz D, Mir S, Balat A, Szczepanska M, Paripovic D, Zurowska A, Bogdanovic R, Yilmaz A, Ranchin B, Baskin E, Erdogan O, Remuzzi G, Firszt-Adamczyk A, Kuzma-Mroczkowska E, Litwin M, Murer L, Tkaczyk M, Jardim H, Wasilewska A, Printza N, Fidan K, Simkova E, Borzecka H, Staude H, Hees K, Schaefer F, PodoNet C. Long-Term Outcome of Steroid-Resistant Nephrotic Syndrome in Children. J Am Soc Nephrol. 2017;28(10):3055-65.

2016

Buscher AK, Beck BB, Melk A, Hoefele J, Kranz B, Bamborschke D, Baig S, Lange-Sperandio B, Jungraithmayr T, Weber LT, Kemper MJ, Tonshoff B, Hoyer PF, Konrad M, Weber S, German Pediatric Nephrology A. Rapid Response to Cyclosporin A and Favorable Renal Outcome in Nongenetic Versus Genetic Steroid-Resistant Nephrotic Syndrome. Clin J Am Soc Nephrol. 2016;11(2):245-53.

Doyon A, Schmiedchen B, Sander A, Bayazit A, Duzova A, Canpolat N, Thurn D, Azukaitis K, Anarat A, Bacchetta J, Mir S, Shroff R, Yilmaz E, Candan C, Kemper M, Fischbach M, Cortina G, Klaus G, Wuttke M, Kottgen A, Melk A, Querfeld U, Schaefer F, Consortium CS. Genetic, Environmental, and Disease-Associated Correlates of Vitamin D Status in Children with CKD. Clin J Am Soc Nephrol. 2016;11(7):1145-53.

Filler G, Melk A, Marks SD. Practice recommendations for the monitoring of renal function in pediatric non-renal organ transplant recipients. Pediatr Transplant. 2016;20(3):352-63.

Korkmaz E, Lipska-Zietkiewicz BS, Boyer O, Gribouval O, Fourrage C, Tabatabaei M, Schnaidt S, Gucer S, Kaymaz F, Arici M, Dinckan A, Mir S, Bayazit AK, Emre S, Balat A, Rees L, Shroff R, Bergmann C, Mourani C, Antignac C, Ozaltin F, Schaefer F, PodoNet C. ADCK4-Associated Glomerulopathy Causes Adolescence-Onset FSGS. J Am Soc Nephrol. 2016;27(1):63-8.

Melk A, Baisantry A, Schmitt R. The yin and yang of autophagy in acute kidney injury. Autophagy. 2016;12(3):596-7.

Dong L, Nordlohne J, Ge S, Hertel B, Melk A, Rong S, Haller H, von Vietinghoff S. T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment. Journal of the American Society of Nephrology : JASN. 2016;27(6):1753-64.

Bhayadia R, Schmidt BM, Melk A, Homme M. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. J Gerontol A Biol Sci Med Sci. 2016;71(2):161-9.

Baisantry A, Bhayana S, Wrede C, Hegermann J, Haller H, Melk A, Schmitt R. The impact of autophagy on the development of senescence in primary tubular epithelial cells. Cell Cycle. 2016;15(21):2973-9.

Baisantry A, Bhayana S, Rong S, Ermeling E, Wrede C, Hegermann J, Pennekamp P, Sorensen-Zender I, Haller H, Melk A, Schmitt R. Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments. Journal of the American Society of Nephrology : JASN. 2016;27(6):1609-16.

2015

Susnik N, Melk A, Schmitt R. Cell aging and kidney repair. Cell Cycle. 2015;14(22):3521-2.

Wuttke M, Wong CS, Wuhl E, Epting D, Luo L, Hoppmann A, Doyon A, Li Y, Consortium CK, Sozeri B, Thurn D, Helmstadter M, Huber TB, Blydt-Hansen TD, Kramer-Zucker A, Mehls O, Melk A, Querfeld U, Furth SL, Warady BA, Schaefer F, Kottgen A. Genetic Loci Associated with Renal Function Measures and Chronic Kidney Disease in Children: The Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium. Nephrol Dial Transplant. 2015.

Trautmann A, Bodria M, Ozaltin F, Gheisari A, Melk A, Azocar M, Anarat A, Caliskan S, Emma F, Gellermann J, Oh J, Baskin E, Ksiazek J, Remuzzi G, Erdogan O, Akman S, Dusek J, Davitaia T, Ozkaya O, Papachristou F, Firszt-Adamczyk A, Urasinski T, Testa S, Krmar RT, Hyla-Klekot L, Pasini A, Ozcakar ZB, Sallay P, Cakar N, Galanti M, Terzic J, Aoun B, Caldas Afonso A, Szymanik-Grzelak H, Lipska BS, Schnaidt S, Schaefer F, PodoNet C. Spectrum of Steroid-Resistant and Congenital Nephrotic Syndrome in Children: The Podonet Registry Cohort. Clin J Am Soc Nephrol. 2015;10(4):592-600.

Thurn D, Doyon A, Sozeri B, Bayazit AK, Canpolat N, Duzova A, Querfeld U, Schmidt BM, Schaefer F, Wuhl E, Melk A, Consortium CS. Aortic Pulse Wave Velocity in Healthy Children and Adolescents: Reference Values for the Vicorder Device and Modifying Factors. Am J Hypertens. 2015;28(12):1480-8.

Stuart HM, Roberts NA, Hilton EN, McKenzie EA, Daly SB, Hadfield KD, Rahal JS, Gardiner NJ, Tanley SW, Lewis MA, Sites E, Angle B, Alves C, Lourenco T, Rodrigues M, Calado A, Amado M, Guerreiro N, Serras I, Beetz C, Varga RE, Silay MS, Darlow JM, Dobson MG, Barton DE, Hunziker M, Puri P, Feather SA, Goodship JA, Goodship TH, Lambert HJ, Cordell HJ, Group UVS, Saggar A, Kinali M, Group CS, Lorenz C, Moeller K, Schaefer F, Bayazit AK, Weber S, Newman WG, Woolf AS. Urinary Tract Effects of Hpse2 Mutations. J Am Soc Nephrol. 2015;26(4):797-804.

Sorensen-Zender I, Bhayana S, Susnik N, Rolli V, Batkai S, Baisantry A, Bahram S, Sen P, Teng B, Lindner R, Schiffer M, Thum T, Melk A, Haller H, Schmitt R. Zinc-Alpha2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart. J Am Soc Nephrol. 2015;26(11):2659-68.

Schmitt R, Susnik N, Melk A. Molecular Aspects of Renal Senescence. Curr Opin Organ Transplant. 2015;20(4):412-6.

Schmidt B, Thurn-Valsassina D, Duzowa A, Soezeri B, Bayazit A, Caliskan S, Querfeld U, Azukaitis K, Wuehl U, Schafer F, Melk A. 1d.06: Longitudinal Evaluation of Cardiovascular Risk after Pediatric Kidney Transplantation. J Hypertens. 2015;33 Suppl 1:e16.

Schmidt B, Thurn-Valsassina D, Beier R, Melk A. 3b.06: Cardiovascular Risk in Pediatric Recipients of Stem Cell Transplantation. J Hypertens. 2015;33 Suppl 1:e35.

Schildhorn C, Jacobi C, Weissbrodt A, Hermstedt C, Westhoff JH, Homme M, Bhayadia R, Gretz N, Falk CS, Schmitt R, Brocker V, Kranzlin B, Melk A. Renal Phenotype of Young and Old Telomerase-Deficient Mice. Mech Ageing Dev. 2015;150:65-73.

Hoenecke J, Hartmann H, Melk A. Arterial Hypertension in Children with Hemolytic Uremic Syndrome after Kidney Transplantation. Pediatr Transplant. 2015;19(5):504-9.

Doyon A, Fischer DC, Bayazit AK, Canpolat N, Duzova A, Sozeri B, Bacchetta J, Balat A, Buscher A, Candan C, Cakar N, Donmez O, Dusek J, Heckel M, Klaus G, Mir S, Ozcelik G, Sever L, Shroff R, Vidal E, Wuhl E, Gondan M, Melk A, Querfeld U, Haffner D, Schaefer F, Consortium CS. Markers of Bone Metabolism Are Affected by Renal Function and Growth Hormone Therapy in Children with Chronic Kidney Disease. PLoS One. 2015;10(2):e0113482.

2014

Susnik N, Sorensen-Zender I, Rong S, von Vietinghoff S, Lu X, Rubera I, Tauc M, Falk CS, Alexander WS, Melk A, Haller H, Schmitt R. Ablation of Proximal Tubular Suppressor of Cytokine Signaling 3 Enhances Tubular Cell Cycling and Modifies Macrophage Phenotype During Acute Kidney Injury. Kidney Int. 2014;85(6):1357-68.

Sorensen-Zender I, Rong S, Susnik N, Zender S, Pennekamp P, Melk A, Haller H, Schmitt R. Renal Tubular Notch Signaling Triggers a Prosenescent State after Acute Kidney Injury. Am J Physiol Renal Physiol. 2014;306(8):F907-15.

Melk A, Tegtbur U, Hilfiker-Kleiner D, Eberhard J, Saretzki G, Eulert C, Kerling A, Nelius AK, Homme M, Strunk D, Berliner D, Rontgen P, Kuck M, Bauersachs J, Hilfiker A, Haverich A, Bara C, Stiesch M. Improvement of Biological Age by Physical Activity. Int J Cardiol. 2014;176(3):1187-9.

Lipska BS, Ranchin B, Iatropoulos P, Gellermann J, Melk A, Ozaltin F, Caridi G, Seeman T, Tory K, Jankauskiene A, Zurowska A, Szczepanska M, Wasilewska A, Harambat J, Trautmann A, Peco-Antic A, Borzecka H, Moczulska A, Saeed B, Bogdanovic R, Kalyoncu M, Simkova E, Erdogan O, Vrljicak K, Teixeira A, Azocar M, Schaefer F, PodoNet C. Genotype-Phenotype Associations in Wt1 Glomerulopathy. Kidney Int. 2014;85(5):1169-78.

Kumarswamy R, Volkmann I, Beermann J, Napp LC, Jabs O, Bhayadia R, Melk A, Ucar A, Chowdhury K, Lorenzen JM, Gupta SK, Batkai S, Thum T. Vascular Importance of the Mir-212/132 Cluster. Eur Heart J. 2014;35(45):3224-31.

Eberhard J, Stiesch M, Kerling A, Bara C, Eulert C, Hilfiker-Kleiner D, Hilfiker A, Budde E, Bauersachs J, Kuck M, Haverich A, Melk A, Tegtbur U. Moderate and Severe Periodontitis Are Independent Risk Factors Associated with Low Cardiorespiratory Fitness in Sedentary Non-Smoking Men Aged between 45 and 65 Years. J Clin Periodontol. 2014;41(1):31-7.

Doyon A, Kracht D, Bayazit AK, Deveci M, Duzova A, Krmar RT, Litwin M, Niemirska A, Oguz B, Schmidt BM, Sozeri B, Querfeld U, Melk A, Schaefer F, Wuhl E, Consortium CRS. Response to Intima-Media Thickness in Children--Need for More Parameters. Hypertension. 2014;63(5):e121-2.

Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sorensen-Zender I, Broecker V, Haller H, Melk A, Schmitt R. In Vivo and in Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells. PLoS One. 2014;9(2):e88071.

Bauer A, Loos S, Wehrmann C, Horstmann D, Donnerstag F, Lemke J, Hillebrand G, Lobel U, Pape L, Haffner D, Bindt C, Ahlenstiel T, Melk A, Lehnhardt A, Kemper MJ, Oh J, Hartmann H. Neurological Involvement in Children with E. Coli O104:H4-Induced Hemolytic Uremic Syndrome. Pediatr Nephrol. 2014;29(9):1607-15.

2013

Sorensen-Zender I, Rong S, Susnik N, Lange J, Gueler F, Degen JL, Melk A, Haller H, Schmitt R. Role of Fibrinogen in Acute Ischemic Kidney Injury. Am J Physiol Renal Physiol. 2013;305(5):F777-85.

Schock-Kusch D, Geraci S, Ermeling E, Shulhevich Y, Sticht C, Hesser J, Stsepankou D, Neudecker S, Pill J, Schmitt R, Melk A. Reliability of Transcutaneous Measurement of Renal Function in Various Strains of Conscious Mice. PLoS One. 2013;8(8):e71519.

Melk A, Schildhorn C, Homme M, Knoch M, Schmidt BM, Serth J, Scherer S, Dohler B, Opelz G. Association of Single Nucleotide Polymorphisms on Chromosome 9p21.3 with Cardiovascular Death in Kidney Transplant Recipients. Transplantation. 2013;95(7):928-32.

Lipska BS, Iatropoulos P, Maranta R, Caridi G, Ozaltin F, Anarat A, Balat A, Gellermann J, Trautmann A, Erdogan O, Saeed B, Emre S, Bogdanovic R, Azocar M, Balasz-Chmielewska I, Benetti E, Caliskan S, Mir S, Melk A, Ertan P, Baskin E, Jardim H, Davitaia T, Wasilewska A, Drozdz D, Szczepanska M, Jankauskiene A, Higuita LM, Ardissino G, Ozkaya O, Kuzma-Mroczkowska E, Soylemezoglu O, Ranchin B, Medynska A, Tkaczyk M, Peco-Antic A, Akil I, Jarmolinski T, Firszt-Adamczyk A, Dusek J, Simonetti GD, Gok F, Gheissari A, Emma F, Krmar RT, Fischbach M, Printza N, Simkova E, Mele C, Ghiggeri GM, Schaefer F, PodoNet C. Genetic Screening in Adolescents with Steroid-Resistant Nephrotic Syndrome. Kidney Int. 2013;84(1):206-13.

Doyon A, Kracht D, Bayazit AK, Deveci M, Duzova A, Krmar RT, Litwin M, Niemirska A, Oguz B, Schmidt BM, Sozeri B, Querfeld U, Melk A, Schaefer F, Wuhl E, Consortium CS. Carotid Artery Intima-Media Thickness and Distensibility in Children and Adolescents: Reference Values and Role of Body Dimensions. Hypertension. 2013;62(3):550-6.

2006 - 2012

2012

Schmitt R, Melk A. New Insights on Molecular Mechanisms of Renal Aging. Am J Transplant. 2012;12(11):2892-900.

Braun H, Schmidt BM, Raiss M, Baisantry A, Mircea-Constantin D, Wang S, Gross ML, Serrano M, Schmitt R, Melk A. Cellular Senescence Limits Regenerative Capacity and Allograft Survival. J Am Soc Nephrol. 2012;23(9):1467-73.

2011

Sorensen I, Susnik N, Inhester T, Degen JL, Melk A, Haller H, Schmitt R. Fibrinogen, Acting as a Mitogen for Tubulointerstitial Fibroblasts, Promotes Renal Fibrosis. Kidney Int. 2011;80(10):1035-44.

Sorensen I, Rong S, Susnik N, Gueler F, Shushakova N, Albrecht M, Dittrich AM, von Vietinghoff S, Becker JU, Melk A, Bohlmann A, Reingruber S, Petzelbauer P, Haller H, Schmitt R. Bbeta(15-42) Attenuates the Effect of Ischemia-Reperfusion Injury in Renal Transplantation. J Am Soc Nephrol. 2011;22(10):1887-96.

Kracht D, Shroff R, Baig S, Doyon A, Jacobi C, Zeller R, Querfeld U, Schaefer F, Wuhl E, Schmidt BM, Melk A, Consortium CS. Validating a New Oscillometric Device for Aortic Pulse Wave Velocity Measurements in Children and Adolescents. Am J Hypertens. 2011;24(12):1294-9.

Jacobi C, Homme M, Melk A. Is Cellular Senescence Important in Pediatric Kidney Disease? Pediatr Nephrol. 2011;26(12):2121-31.

2010

Kanzelmeyer NK, Ahlenstiel T, Drube J, Froede K, Kreuzer M, Broecker V, Ehrich JH, Melk A, Pape L. Protocol biopsy-driven interventions after pediatric renal transplantation. Pediatr Transplant. 2010;14(8):1012-8.

Querfeld U, Anarat A, Bayazit AK, Bakkaloglu AS, Bilginer Y, Caliskan S, Civilibal M, Doyon A, Duzova A, Kracht D, Litwin M, Melk A, Mir S, Sozeri B, Shroff R, Zeller R, Wuhl E, Schaefer F, Group CS. The Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study: objectives, design, and methodology. Clin J Am Soc Nephrol. 2010;5(9):1642-8.

Westhoff JH, Schildhorn C, Jacobi C, Homme M, Hartner A, Braun H, Kryzer C, Wang C, von Zglinicki T, Kranzlin B, Gretz N, Melk A. Telomere shortening reduces regenerative capacity after acute kidney injury. J Am Soc Nephrol. 2010;21(2):327-36.

2009

Melk A, Schmidt BM, Braun H, Vongwiwatana A, Urmson J, Zhu LF, Rayner D, Halloran PF. Effects of donor age and cell senescence on kidney allograft survival. Am J Transplant. 2009;9(1):114-23.

Schmitt R, Jacobi C, Susnik N, Broecker V, Haller H, Melk A. Ageing mouse kidney--not always the SAME old story. Nephrol Dial Transplant. 2009;24(10):3002-5.

2008

Billing H, Rieger S, Ovens J, Susal C, Melk A, Waldherr R, Opelz G, Tonshoff B. Successful treatment of chronic antibody-mediated rejection with IVIG and rituximab in pediatric renal transplant recipients. Transplantation. 2008;86(9):1214-21.

Westhoff JH, Hilgers KF, Steinbach MP, Hartner A, Klanke B, Amann K, Melk A. Hypertension induces somatic cellular senescence in rats and humans by induction of cell cycle inhibitor p16INK4a. Hypertension. 2008;52(1):123-9.

test
Diese Webseite verwendet Cookies und die Webanalyse-Software Google Analytics. Klicken Sie hier für weitere Informationen zum Datenschutz.
Einverstanden