Vascular Remodelling and Regeneration

Objectives

Acute or chronic vascular injury and inflammation results in a dysfunction and de-differentiation of endothelial- and smooth muscle cells. As a consequence, the imbalance of an impaired endothelial regenerative capacity on the one hand and an inadequate proliferation and secretory activity of smooth muscle cells on the other hand, results in pathologic vascular remodeling and vessel narrowing. 

Our aim is to elucidate the intracellular signalling mechanisms that trigger the dedifferentiation of endothelial- and smooth muscle cells. In this context, the group focusses especially on signaling molecules and transcription factors that regulate epigenetic processes and thus control the differentiation of vascular cells like Forkhead box O (FoxO-) transcription factors and sirtuins. Moreover, microRNAs that regulate these signalling pathways are investigated. 

The aim of these projects is to develop novel strategies for the treatment of atherosclerosis or in-stent restenosis as well as for the improvement of therapeutic angiogenesis. 

Research Focus

The main research interest and expertise of the group is in the field of vascular biology and medicine.  
The group especially focuses on the signaltransduction processes in vascular cells (smooth muscle- and endothelial cells) that modulate vascular disease processes like atherosclerosis, restenosis and pulmonary hypertension. Moreover, the underlying mechanisms of impaired endothelial function, namely re-endothelialization and angiogenesis are in the focus of current projects. By combining up to date molecular- and cell biology techniques with different animal models and clinical approaches, the group aims to develop novel translational approaches and strategies for the diagnosis, prevention and treatment of these vascular diseases. 
Embedded in the sizzling and stimulating surrounding of the Cluster of Excellence REBIRTH and an international DFG research training group as well as in close interaction and collaboration with local, national and international experts, the team works in the field of cutting edge research regarding vascular remodeling- and regenerative processes. 

Collaborations

  • J. Bauersachs / D. Fraccarrollo Hannover Medical School, Cardiology and Angiology, Myocardial infarction surgery in mice
  • T. Thum, REBIRTH Unit miRNA in Myocardial Regeneration, IMTTS, MHH Analysis of microRNA function during vascular remodeling
  • F. Limbourg, REBIRTH Unit Regenerative Agents, MHH: Hindlimb ischemia surgery in mice
  • S. Dimmeler, University of Frankfurt, Institute of Cardiovascular Regeneration, microRNA knock out mice and miR function in vascular cells.
  • W. Seeger, University of Gießen, models of pulmonary artery hypertension and mechansisms of vascular remodeling in the pulmonary vasculature
  • C. Hamm, University of Gießen, Biobank of vascular tissues and clinical sample collection / risk stratification of vascular patients
  • R. Braun-Dullaeus, University of Magdeburg, cell cycle regulation in smooth muscle cells
  • P. Libby / K Croce, Harvard Medical School, Cardiology, role of GSNOR in vascular remodeling
  • J. Clardy, Harvard Medical School, Biochemistry, design of small molecule activators of FoxO transcription factors 

AWARDS

  • Scholarship of the „Studienstiftung des Deutschen Volkes“ (1996-2000)
  • Scholarship of the research training program Graduiertenkollegs 534: „Biol. Grundlagen der vask Medizin“ (2000-2002)
  • PostDoc scholarship of the German Cardiac Society „Deutschen Gesellschaft für Kardiologie“ (2003-2005)
  • Poster Award, 3. European Meeting on Vascular Biology and Medicine, Hamburg (2005)
  • Young Investigator Award, 21. Kardiologen/Physiologen Meeting, Lübeck (2005)
  • Rudolf-Thauer-Poster-Award at the „Jahrestagung der Deutschen Gesellschaft für Kardiologie“, Mannheim (2006)
  • Best Abstract Award: 114. Internistenkongress der Deutschen Gesellschaft für Innere Medizin, Wiesbaden (2008)
  • Rudi Busse Young Investigator Award (1st winner) of the German Cardiac Society „Jahrestagung der Deutschen Gesellschaft für Kardiologie“, Mannheim (2009)
  • Albert Fraenkel Award of the German Cardiac Society „jahrestagung der Deutschen Gesellschaft für Kardiologie“, Mannheim (2011)

Publications

2013 - ongoing

2017

Dutzmann J, Koch A, Weisheit S, Sonnenschein K, Korte L, Haertle M, Thum T, Bauersachs J, Sedding DG, Daniel JM. Sonic hedgehog-dependent activation of adventitial fibroblasts promotes neointima formation. Cardiovasc Res. 2017/11/01 ed2017. p. 1653-63.

Dutzmann J, Musmann RJ, Haertle M, Daniel JM, Sonnenschein K, Schafer A, Kolkhof P, Bauersachs J, Sedding DG. The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury. PLoS One. 2017;12(9):e0184888. Epub 2017/09/20.

Boyle EC, Sedding DG, Haverich A. Targeting vasa vasorum dysfunction to prevent atherosclerosis. Vascul Pharmacol. 2017;96-98:5-10. Epub 2017/08/24.

Stieger P, Daniel JM, Tholen C, Dutzmann J, Knopp K, Gunduz D, Aslam M, Kampschulte M, Langheinrich A, Fischer S, Cabrera-Fuentes H, Wang Y, Wollert KC, Bauersachs J, Braun-Dullaeus R, Preissner KT, Sedding DG. Targeting of Extracellular RNA Reduces Edema Formation and Infarct Size and Improves Survival After Myocardial Infarction in Mice. J Am Heart Assoc. 2017;6(6). Epub 2017/06/24.

Daniel JM, Dutzmann J, Brunsch H, Bauersachs J, Braun-Dullaeus R, Sedding DG. Systemic application of sirolimus prevents neointima formation not via a direct anti-proliferative effect but via its anti-inflammatory properties. Int J Cardiol. 2017;238:79-91. Epub 2017/04/24.

Riehle C, Scharf GM, Sieweke JT, Zauner F, Flierl U, Treptau J, Zormpas C, Senf J, McCarty NS, Bauersachs J, Sedding DG, Westhoff-Bleck M. Leukocytoclastic vasculitis associated with endocarditis in a patient with transposition of the great arteries and mechanical valve replacement. Cardiovasc Pathol. 2017;27:68-70. Epub 2017/02/09.

Gunduz D, Tanislav C, Sedding D, Parahuleva M, Santoso S, Troidl C, Hamm CW, Aslam M. Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation. Int J Mol Sci. 2017;18(2). Epub 2017/02/02.

2016

Napp LC, Jabs O, Hockelmann A, Dutzmann J, Kapopara PR, Sedding DG, Gaestel M, Bauersachs J, Bavendiek U. Normal endothelial but impaired arterial development in MAP-Kinase activated protein kinase 2 (MK2) deficient mice. Vasc Cell. 2016;8:4. Epub 2016/10/30.

Daniel JM, Reichel CA, Schmidt-Woell T, Dutzmann J, Zuchtriegel G, Krombach F, Herold J, Bauersachs J, Sedding DG, Kanse SM. Factor VII-activating protease deficiency promotes neointima formation by enhancing leukocyte accumulation. J Thromb Haemost. 2016;14(10):2058-67. Epub 2016/10/28.

Cabrera-Fuentes HA, Aragones J, Bernhagen J, Boening A, Boisvert WA, Botker HE, Bulluck H, Cook S, Di Lisa F, Engel FB, Engelmann B, Ferrazzi F, Ferdinandy P, Fong A, Fleming I, Gnaiger E, Hernandez-Resendiz S, Kalkhoran SB, Kim MH, Lecour S, Liehn EA, Marber MS, Mayr M, Miura T, Ong SB, Peter K, Sedding D, Singh MK, Suleiman MS, Schnittler HJ, Schulz R, Shim W, Tello D, Vogel CW, Walker M, Li QO, Yellon DM, Hausenloy DJ, Preissner KT. From basic mechanisms to clinical applications in heart protection, new players in cardiovascular diseases and cardiac theranostics: meeting report from the third international symposium on "New frontiers in cardiovascular research". Basic Res Cardiol. 2016;111(6):69. Epub 2016/10/16.

Merseburger A, Sedding D. [GnRH agonist in PCa patients with clinically significant pre-existing cardiovascular disease]. Urologe A. 2016;55(9):1240-1. Epub 2016/07/28. GnRH-Antagonisten bei PCa-Patienten mit klinisch relevanter kardiovaskularer Vorerkrankung.

Daniel JM, Prock A, Dutzmann J, Sonnenschein K, Thum T, Bauersachs J, Sedding DG. Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation. Arterioscler Thromb Vasc Biol. 2016;36(2):317-27. Epub 2015/12/15.

2015

Merseburger AS, Sedding D, Huter K. [Cardiovascular Risk Patients under Androgen Deprivation Therapy : Lower Risk with Gnrh Antagonists Compared to Lhrh Agonists?]. Urologe A. 2015. Kardiovaskulare Risikopatienten unter Androgenentzugstherapie : Geringeres Risiko mit GnRH-Antagonisten im Vergleich zu LHRH-Agonisten?

Gunduz D, Klewer M, Bauer P, Tanislav C, Sedding D, Rohrbach S, Schulz R, Aslam M. Compound C Inhibits in Vitro Angiogenesis and Ameliorates Thrombin-Induced Endothelial Barrier Failure. Eur J Pharmacol. 2015;768:165-72.

Medunjanin S, Daniel JM, Weinert S, Dutzmann J, Burgbacher F, Brecht S, Bruemmer D, Kahne T, Naumann M, Sedding DG, Zuschratter W, Braun-Dullaeus RC. DNA-Dependent Protein Kinase (DNA-Pk) Permits Vascular Smooth Muscle Cell Proliferation through Phosphorylation of the Orphan Nuclear Receptor Nor1. Cardiovasc Res. 2015;106(3):488-97. Epub 2015/04/09.

Daniel JM, Reich F, Dutzmann J, Weisheit S, Teske R, Gunduz D, Bauersachs J, Preissner KT, Sedding DG. Cleaved High-Molecular-Weight Kininogen Inhibits Neointima Formation Following Vascular Injury. Thromb Haemost. 2015;114(3):603-13.

Dutzmann J, Daniel JM, Bauersachs J, Hilfiker-Kleiner D, Sedding DG. Emerging Translational Approaches to Target Stat3 Signalling and Its Impact on Vascular Disease. Cardiovasc Res. 2015;106(3):365-74.

Tillmanns J, Hoffmann D, Habbaba Y, Schmitto JD, Sedding D, Fraccarollo D, Galuppo P, Bauersachs J. Fibroblast Activation Protein Alpha Expression Identifies Activated Fibroblasts after Myocardial Infarction. J Mol Cell Cardiol. 2015;87:194-203.

2014

Dutzmann J, Daniel JM, Bauersachs J, Sedding DG. MiR-92a – a key player in cardiovascular remodeling. RNA & Disease 2014; 1:e371.doi: 10.14800/rd.371

Assmus B, Leistner DM, Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Sedding D, Yu JT, Corti R, Mathey DG, Barth C, Mayer-Wehrstein C, Burck I, Sueselbeck T, Dill T, Hamm CW, Tonn T, Dimmeler S, Zeiher AM, Grp R-AS. Long-Term Clinical Outcome after Intracoronary Application of Bone Marrow-Derived Mononuclear Cells for Acute Myocardial Infarction: Migratory Capacity of Administered Cells Determines Event-Free Survival. European Heart Journal. 2014;35(19):1275-83.

Daniel JM, Penzkofer D, Teske R, Dutzmann J, Koch A, Bielenberg W, Bonauer A, Boon RA, Fischer A, Bauersachs J, van Rooij E, Dimmeler S, Sedding DG. Inhibition of Mir-92a Improves Re-Endothelialization and Prevents Neointima Formation Following Vascular Injury. Cardiovascular Research. 2014;103(4):564-72.

Kampschulte M, Gunkel I, Stieger P, Sedding DG, Brinkmann A, Ritman EL, Krombach GA, Langheinrich AC. Thalidomide Influences Atherogenesis in Aortas of Apoe(-/-)/Ldlr-/- Double Knockout Mice: A Nano-Ct Study. International Journal of Cardiovascular Imaging. 2014;30(4):795-802.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS. Pro-Proliferative and Inflammatory Signaling Converge on Foxo1 Transcription Factor in Pulmonary Hypertension. Nature Medicine. 2014;20(11):1289-300.

2013

Babelova A, Sedding DG, Brandes RP. Anti-Atherosclerotic Mechanisms of Statin Therapy. Current Opinion in Pharmacology. 2013;13(2):260-4.

Dorr O, Liebetrau C, Mollmann H, Achenbach S, Sedding D, Szardien S, Willmer M, Rixe J, Troidl C, Elsasser A, Hamm C, Nef HM. Renal Sympathetic Denervation Does Not Aggravate Functional or Structural Renal Damage. Journal of the American College of Cardiology. 2013;61(4):479-80.

Sedding DG, Widmer-Teske R, Mueller A, Stieger P, Daniel JM, Gunduz D, Pullamsetti S, Nef H, Moellmann H, Troidl C, Hamm C, Braun-Dullaeus R. Role of the Phosphatase Pten in Early Vascular Remodeling. Plos One. 2013;8(3).

Aslam M, Sedding D, Koshty A, Santoso S, Schulz R, Hamm C, Gunduz D. Nucleoside Triphosphates Inhibit Adp, Collagen, and Epinephrine-Induced Platelet Aggregation: Role of P2y(1) and P2y(12) Receptors. Thrombosis Research. 2013;132(5):548-57.

2006 - 2012

2012

Dorr O, Mollmann H, Achenbach S, Sedding D, Basic D, Liebetrau C, Szardien S, Elsasser A, Roth P, Boning A, Hamm C, Nef HM. Transapical Coronary Artery Intervention "First-in-Man" Experience. Circulation-Cardiovascular Interventions. 2012;5(3):446-7.

Gunduz D, Aslam M, Krieger U, Becker L, Grebe M, Arshad M, Sedding DG, Hartel FV, Abdallah Y, Piper HM, Voss RK, Noll T. Opposing Effects of Atp and Adenosine on Barrier Function of Rat Coronary Microvasculature. Journal of Molecular and Cellular Cardiology. 2012;52(5):962-70.

Bloch M, Prock A, Paonessa F, Benz V, Bahr IN, Herbst L, Witt H, Kappert K, Spranger J, Stawowy P, Unger T, Fusco A, Sedding D, Brunetti A, Foryst-Ludwig A, Kintscher U. High-Mobility Group A1 Protein a New Coregulator of Peroxisome Proliferator-Activated Receptor-Gamma-Mediated Transrepression in the Vasculature. Circulation Research. 2012;110(3):394-U82.

Daniel JM, Dutzmann J, Bielenberg W, Widmer-Teske R, Gunduz D, Hamm CW, Sedding DG. Inhibition of Stat3 Signaling Prevents Vascular Smooth Muscle Cell Proliferation and Neointima Formation. Basic Research in Cardiology. 2012;107(3).

2011

Stolz E, Yeniguen M, Kreisel M, Kampschulte M, Doenges S, Sedding D, Ritman EL, Gerriets T, Langheinrich AC. Angioarchitectural Changes in Subacute Cerebral Venous Thrombosis. A Synchrotron-Based Micro- and Nano-Ct Study. Neuroimage. 2011;54(3):1881-6.

Sklepkiewicz P, Schermuly RT, Tian X, Ghofrani HA, Weissmann N, Sedding D, Kashour T, Seeger W, Grimminger F, Pullamsetti SS. Glycogen Synthase Kinase 3beta Contributes to Proliferation of Arterial Smooth Muscle Cells in Pulmonary Hypertension. Plos One. 2011;6(4).

Aslam M, Gunduz D, Schuler D, Li L, Sharifpanah F, Sedding D, Piper HM, Noll T. Intermedin Induces Loss of Coronary Microvascular Endothelial Barrier Via Derangement of Actin Cytoskeleton: Role of Rhoa and Rac1. Cardiovascular Research. 2011;92(2):276-86.

Daniel JM, Sedding DG. Circulating Smooth Muscle Progenitor Cells in Arterial Remodeling. Journal of Molecular and Cellular Cardiology. 2011;50(2):273-9.

2010

Hecker M, Zaslona Z, Kwapiszewska G, Niess G, Zakrzewicz A, Hergenreider E, Wilhelm J, Marsh LM, Sedding D, Klepetko W, Lohmeyer J, Dimmeler S, Seeger W, Weissmann N, Schermuly RT, Kneidinger N, Eickelberg O, Morty RE. Dysregulation of the Il-13 Receptor System a Novel Pathomechanism in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2010;182(6):805-18.

Gunduz D, Thom J, Hussain I, Lopez D, Hartel FV, Erdogan A, Grebe M, Sedding D, Piper HM, Tillmanns H, Noll T, Aslam M. Insulin Stabilizes Microvascular Endothelial Barrier Function Via Phosphatidylinositol 3-Kinase/Akt-Mediated Rac1 Activation. Arteriosclerosis Thrombosis and Vascular Biology. 2010;30(6):1237-U363.

Kampschulte M, Brinkmann A, Stieger P, Sedding DG, Dierkes C, Bohle RM, Krombach G, Ritman EL, Langheinrich AC. Quantitative Ct Imaging of the Spatio-Temporal Distribution Patterns of Vasa Vasorum in Aortas of Apoe(-/-)/Ldl-/- Double Knockout Mice. Atherosclerosis. 2010;212(2):444-50.

Grebe MT, Luu B, Sedding D, Heidt MC, Kemkes-Matthes B, Schaefer CA, Tillmanns HH, Gunduz D. Fibrinogen Promotes Early Atherosclerotic Changes of the Carotid Artery in Young, Healthy Adults. Journal of Atherosclerosis and Thrombosis. 2010;17(10):1003-8.

Backes A, Seay U, Sedding DG, Tillmanns HH, Braun-Dullaeus RC. Inhibition of Matrix Deposition: A New Strategy for Prevention of Restenosis after Balloon Angioplasty. Journal of Cardiovascular Pharmacology. 2010;55(2):213-8.

Seeger FH, Sedding D, Langheinrich AC, Haendeler J, Zeiher AM, Dimmeler S. Inhibition of the P38 Map Kinase in Vivo Improves Number and Functional Activity of Vasculogenic Cells and Reduces Atherosclerotic Disease Progression. Basic Research in Cardiology. 2010;105(3):389-97.

Daniel JM, Bielenberg W, Stieger P, Weinert S, Tillmanns H, Sedding DG. Time-Course Analysis on the Differentiation of Bone Marrow-Derived Progenitor Cells into Smooth Muscle Cells During Neointima Formation. Arteriosclerosis Thrombosis and Vascular Biology. 2010;30(10):1890-U43.

2009

Sedding DG, Trobs M, Reich F, Walker G, Fink L, Haberbosch W, Rau W, Tillmanns H, Preissner KT, Bohle RM, Langheinrich AC. 3-Deazaadenosine Prevents Smooth Muscle Cell Proliferation and Neointima Formation by Interfering with Ras Signaling. Circulation Research. 2009;104(10):1192-U161.

Shibamiya A, Hersemeyer K, Woll TS, Sedding D, Daniel JM, Bauer S, Koyama T, Preissner KT, Kanse SM. A Key Role for Toll-Like Receptor-3 in Disrupting the Hemostasis Balance on Endothelial Cells. Blood. 2009;113(3):714-22.

Langheinrich AC, Sedding DG, Kampschulte M, Moritz R, Wilhelm J, Haberbosch WG, Ritman EL, Bohle RM. 3-Deazaadenosine Inhibits Vasa Vasorum Neovascularization in Aortas of Apoe(-/-)/Ldl-/- Double Knockout Mice. Atherosclerosis. 2009;202(1):103-10.

Seeger FH, Hess W, Sedding D, Becker G, Kinscherf R, Braun-Dullaeus RC, Viedt C, Kreuzer J. The Nucleotide Analogue 3-Deazaadenosine Prevents Neointima-Formation after Balloon Injury. Biochemical and Biophysical Research Communications. 2009;378(4):826-31.

Heidt MC, Sedding D, Stracke SKH, Stadlbauer T, Boening A, Vogt PR, Schonburg M. Measurement of Myocardial Oxygen Tension: A Valid and Sensitive Method in the Investigation of Transmyocardial Laser Revascularization in an Acute Ischemia Model. Thoracic and Cardiovascular Surgeon. 2009;57(2):79-84.

Tillmanns H, Erdogan A, Sedding D. Treatment of Chronic Cad - Do the Guidelines (Esc, Aha) Reflect Daily Practice? Herz. 2009;34(1):39-54.

2008

Parahuleva MS, Kanse SM, Parviz B, Barth A, Tillmanns H, Bohle RM, Sedding DG, Hoelschermann H. Factor Seven Activating Protease (Fsap) Expression in Human Monocytes and Accumulation in Unstable Coronary Atherosclerotic Plaques. Atherosclerosis. 2008;196(1):164-71.

Sedding DG. Foxo Transcription Factors in Oxidative Stress Response and Ageing - a New Fork on the Way to Longevity? Biological Chemistry. 2008;389(3):279-83.

Kanse SM, Parahuleva M, Muhl L, Kemkes-Matthes B, Sedding D, Preissner KT. Factor Vii-Activating Protease (Fsap): Vascular Functions and Role in Atherosclerosis. Thrombosis and Haemostasis. 2008;99(2):286-9.

Sedding DG, Homann M, Seay U, Tillmanns H, Preissner KT, Braun-Dullaeus RC. Calpain Counteracts Mechanosensitive Apoptosis of Vascular Smooth Muscle Cells in Vitro and in Vivo. Faseb Journal. 2008;22(2):579-89.

Simonis G, Wiedemann S, Schwarz K, Christ T, Sedding DG, Yu XJ, Marquetant R, Braun-Dullaeus RC, Ravens U, Strasser RH. Chelerythrine Treatment Influences the Balance of Pro- and Anti-Apoptotic Signaling Pathways in the Remote Myocardium after Infarction. Molecular and Cellular Biochemistry. 2008;310(1-2):119-28.

2007

Sedding D, Haendeler J. Do We Age on Sirt1 Expression? Circulation Research. 2007;100(10):1396-8.

Langheinrich AC, Michniewicz A, Sedding DG, Lai B, Jorgensen SM, Bohle RM, Ritman EL. Quantitative X-Ray Imaging of Intraplaque Hemorrhage in Aortas of Apoe(-/-)/Ldl(-/-) Double Knockout Mice. Investigative Radiology. 2007;42(5):263-73.

Kannemeier C, Shibamiya A, Nakazawa F, Trusheim H, Ruppert C, Markart P, Song YT, Tzima E, Kennerknecht E, Niepmann M, von Bruehl ML, Sedding D, Massberg S, Gunther A, Engelmann B, Preissner KT. Extracellular Rna Constitutes a Natural Procoagulant Cofactor in Blood Coagulation. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(15):6388-93.

Konigshoff M, Wilhelm A, Jahn A, Sedding D, Amarie OV, Eul B, Seeger W, Fink L, Gunther A, Eickelberg O, Rose F. The Angiotensin Ii Receptor 2 Is Expressed and Mediates Angiotensin Ii Signaling in Lung Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2007;37(6):640-50.

2006

Langheinrich AC, Michniewicz A, Sedding DG, Walker G, Beighley PE, Rau WS, Bohle RM, Ritman EL. Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E-/-/Low-Density Lipoprotein (-/-) Double Knockout Mice. Arteriosclerosis Thrombosis and Vascular Biology. 2006;26(2):347-52.

Sedding DG, Braun-Dullaeus RC. Caveolin-1: Dual Role for Proliferation of Vascular Smooth Muscle Cells. Trends in Cardiovascular Medicine. 2006;16(2):50-5.

Sedding D, Daniel JM, Muhl L, Hersemeyer K, Brunsch H, Kemkes-Matthes B, Braun-Dullaeus RC, Tillmanns H, Weimer T, Preissner KT, Kanse SM. The G534e Polymorphism of the Gene Encoding the Factor Vii-Activating Protease Is Associated with Cardiovascular Risk Due to Increased Neointima Formation. Journal of Experimental Medicine. 2006;203(13):2801-7.

2005

Weingartner O, Kasper M, Reynen K, Bramke S, Marquetant R, Sedding DG, Braun-Dullaeus R, Strasser RH. Comparative Morphometric and Immunohistological Assessment of the Development of Restenosis after Arterial Injury and a Cholesterol-Rich Diet in Apolipoprotein E -/- Mice and C57bl/6 Control Mice. Coronary Artery Disease. 2005;16(6):391-400.

Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaues RC. Caveolin-1 Facilitates Mechanosensitive Protein Kinase B (Akt) Signaling in Vitro and in Vivo. Circulation Research. 2005;96(6):635-42.

Seay U, Sedding D, Krick S, Hecker M, Seeger W, Eickelberg O. Transforming Growth Factor-Beta-Dependent Growth Inhibition in Primary Vascular Smooth Muscle Cells Is P38-Dependent. Journal of Pharmacology and Experimental Therapeutics. 2005;315(3):1005-12.

2004

Braun-Dullaeus RC, Mann MJ, Sedding DG, Sherwood SW, von der Leyen HE, Dzau VJ. Cell Cycle-Dependent Regulation of Smooth Muscle Cell Activation. Arteriosclerosis Thrombosis and Vascular Biology. 2004;24(5):845-50.

2003

Braun-Dullaeus RC, Dietrich S, Schoaff MJ, Sedding DG, Leithaeuser B, Walker G, Seay U, Matthias RF, Kummer W, Tillmanns H, Haberbosch W. Protective Effect of 3-Deazaadenosine in a Rat Model of Lipopolysaccharide-Induced Myocardial Dysfunction. Shock. 2003;19(3):245-51.

Sedding DG, Seay U, Fink L, Heil M, Kummer W, Tillmanns H, Braun-Dullaeus RC. Mechanosensitive P27(Kip1) Regulation and Cell Cycle Entry in Vascular Smooth Muscle Cells. Circulation. 2003;108(5):616-22.

2002

Degenhardt H, Jansen J, Schulz R, Sedding D, Braun-Dullaeus R, Schluter KD. Mechanosensitive Release of Parathyroid Hormone-Related Peptide from Coronary Endothelial Cells. American Journal of Physiology-Heart and Circulatory Physiology. 2002;283(4):H1489-H96.

Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular Proliferation and Atherosclerosis: New Perspectives and Therapeutic Strategies. Nature Medicine. 2002;8(11):1249-56.

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