Small Animal MRI

Research Focus

Research in the SU MRT focuses on several areas of interest. The primary research projects currently underway in the SU MRT focus on (functional) MR imaging of the heart using dynamic contrast imaging, cinematic imaging and microscopic MR Imaging of transgenic mice. The SU MRT makes modern imaging technology available to collaborators in other departments at MHH and partner research centers.

Collaborations

  • KFO 136, Serial scanning of genetically modified cardivascular disease models in mice 
  • Prof. D. Leibfritz, University of Bremen, Development and optimization of imaging methods 
  • actually with eight REBIRTH working groups

Further Research Projects

  • DFG-SFB 738 ‘Innovative Transplantate’: Reversible cell modification using pseudoretroviral and epiretroviral transduction
  • CliniGene Network of Excellence (European Commission FP6 Research Program, contract LSHBCT- 2006-018933) (‘Nonviral Vector Platform’)

Publications

2013 - ongoing

2017

Leifheit-Nestler M, Kucka J, Yoshizawa E, Behets G, D'Haese P, Bergen C, Meier M, Fischer DC, Haffner D. Comparison of calcimimetic R568 and calcitriol in mineral homeostasis in the Hyp mouse, a murine homolog of X-linked hypophosphatemia. Bone. 2017;103:224-32. Epub 2017/07/22.

Hueper K, Schmidbauer M, Thorenz A, Brasen JH, Gutberlet M, Mengel M, Hartung D, Chen R, Meier M, Haller H, Wacker F, Rong S, Gueler F. Longitudinal evaluation of perfusion changes in acute and chronic renal allograft rejection using arterial spin labeling in translational mouse models. J Magn Reson Imaging. 2017;46(6):1664-72. Epub 2017/03/28.

Tewes S, Gueler F, Chen R, Gutberlet M, Jang MS, Meier M, Mengel M, Hartung D, Wacker F, Rong S, Hueper K. Functional MRI for characterization of renal perfusion impairment and edema formation due to acute kidney injury in different mouse strains. PLoS One. 2017/03/21 ed2017. p. e0173248.

Rojas SV, Meier M, Zweigerdt R, Eckardt D, Rathert C, Schecker N, Schmitto JD, Rojas-Hernandez S, Martin U, Kutschka I, Haverich A, Martens A. Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure. Artificial organs. 2017;41(2):192-9.

2016

Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Li W, Jang MS, Mengel M, Wacker F, Rong S, Gueler F. Kidney Transplantation: Multiparametric Functional Magnetic Resonance Imaging for Assessment of Renal Allograft Pathophysiology in Mice. Invest Radiol. 2016;51(1):58-65.

Hueper K, Gutberlet M, Brasen JH, Jang MS, Thorenz A, Chen R, Hertel B, Barrmeyer A, Schmidbauer M, Meier M, von Vietinghoff S, Khalifa A, Hartung D, Haller H, Wacker F, Rong S, Gueler F. Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice. PloS one. 2016;11(9):e0162705.

Breuer H, Meier M, Schneefeld S, Hartig W, Wittneben A, Markel M, Ross TL, Bengel FM, Bankstahl M, Bankstahl JP. Multimodality imaging of blood-brain barrier impairment during epileptogenesis. J Cereb Blood Flow Metab. 2017;37(6):2049-61. Epub 2016/07/21..

2015

Dreher W, Meier M. 1H NMR spectroscopy in inhomogeneous B0 fields using localized constant time spin echo correlation spectroscopy (L-CT-SECSY). Magnetic Resonance Materials in Physics, Biology and Medicine, October 2015, Volume 28, Issue 1, p 301, DOI: 10.1007/s10334-015-0489-0

Meier M, Haake D. Longitudinal measurement of tissue perfusion in a rat model of magnesium based implants using arterial spin labeling. Magnetic Resonance Materials in Physics, Biology and Medicine, October 2015, Volume 28, Issue 1, p 369, DOI: 10.1007/s10334-015-0489-0

Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Li W, Jang MS, Mengel M, Wacker F, Rong S, Gueler F. Kidney Transplantation: Multiparametric Functional Magnetic Resonance Imaging for Assessment of Renal Allograft Pathophysiology in Mice. Invest Radiol. 2015. Epub 2015/09/16.

Chatterji B, Dickhut C, Mielke S, Kruger J, Just I, Glage S, Meier M, Wedekind D, Pich A. Maldi Imaging Mass Spectrometry to Investigate Endogenous Peptides in an Animal Model of Usher's Disease. Proteomics. 2014;14(13-14):1674-87.

Guseva D, Holst K, Kaune B, Meier M, Keubler L, Glage S, Buettner M, Bleich A, Pabst O, Bachmann O, Ponimaskin EG. Serotonin 5-Ht7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract. Inflamm Bowel Dis. 2014;20(9):1516-29. Epub 2014/07/30.

Hueper K, Gutberlet M, Rong S, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice-Comparison with Histopathologic Results and Renal Function. Radiology. 2014;270(1):117-24.

Hueper K, Peperhove M, Rong S, Gerstenberg J, Mengel M, Meier M, Gutberlet M, Tewes S, Barrmeyer A, Chen R, Haller H, Wacker F, Hartung D, Gueler F. T1-Mapping for Assessment of Ischemia-Induced Acute Kidney Injury and Prediction of Chronic Kidney Disease in Mice. Eur Radiol. 2014;24(9):2252-60.

Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F. Renal Pkc-Epsilon Deficiency Attenuates Acute Kidney Injury and Ischemic Allograft Injury Via Tnf-Alpha-Dependent Inhibition of Apoptosis and Inflammation. Am J Physiol Renal Physiol. 2014;307(6):F718-26. Epub 2014/07/25.

2014

Hueper K, Gutberlet M, Rong S, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice-Comparison with Histopathologic Results and Renal Function. Radiology. 2014;270(1):117-24.

Chatterji B, Dickhut C, Mielke S, Kruger J, Just I, Glage S, Meier M, Wedekind D, Pich A. Maldi Imaging Mass Spectrometry to Investigate Endogenous Peptides in an Animal Model of Usher's Disease. Proteomics. 2014;14(13-14):1674-87.

Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F. Renal Pkc-Epsilon Deficiency Attenuates Acute Kidney Injury and Ischemic Allograft Injury Via Tnf-Alpha-Dependent Inhibition of Apoptosis and Inflammation. Am J Physiol Renal Physiol. 2014;307(6):F718-26.

Guseva D, Holst K, Kaune B, Meier M, Keubler L, Glage S, Buettner M, Bleich A, Pabst O, Bachmann O, Ponimaskin EG. Serotonin 5-Ht7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract. Inflamm Bowel Dis. 2014;20(9):1516-29.

Hueper K, Peperhove M, Rong S, Gerstenberg J, Mengel M, Meier M, Gutberlet M, Tewes S, Barrmeyer A, Chen R, Haller H, Wacker F, Hartung D, Gueler F. T1-Mapping for Assessment of Ischemia-Induced Acute Kidney Injury and Prediction of Chronic Kidney Disease in Mice. Eur Radiol. 2014;24(9):2252-60.

2013

Michael S, Keubler LM, Smoczek A, Meier M, Gunzer F, Pohlmann C, Krause-Buchholz U, Hedrich HJ, Bleich A. Quantitative Phenotyping of Inflammatory Bowel Disease in the Il-10-Deficient Mouse by Use of Noninvasive Magnetic Resonance Imaging. Inflamm Bowel Dis. 2013;19(1):185-93.

Hueper K, Rong S, Gutberlet M, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. T2 Relaxation Time and Apparent Diffusion Coefficient for Noninvasive Assessment of Renal Pathology after Acute Kidney Injury in Mice: Comparison with Histopathology. Invest Radiol. 2013;48(12):834-42.

2006 - 2012

2012

Lu X, Li N, Shushakova N, Schmitt R, Menne J, Susnik N, Meier M, Leitges M, Haller H, Gueler F, Rong S. C57bl/6 and 129/Sv Mice: Genetic Difference to Renal Ischemia-Reperfusion. J Nephrol. 2012;25(5):738-43.

Willenbrock S, Knippenberg S, Meier M, Hass R, Wefstaedt P, Nolte I, Murua Escobar H, Petri S. In Vivo Mri of Intraspinally Injected Spio-Labelled Human Cd34+ Cells in a Transgenic Mouse Model of Als. In Vivo. 2012;26(1):31-8.

Sterenczak KA, Meier M, Glage S, Meyer M, Willenbrock S, Wefstaedt P, Dorsch M, Bullerdiek J, Murua Escobar H, Hedrich H, Nolte I. Longitudinal Mri Contrast Enhanced Monitoring of Early Tumour Development with Manganese Chloride (Mncl2) and Superparamagnetic Iron Oxide Nanoparticles (Spios) in a Ct1258 Based in Vivo Model of Prostate Cancer. BMC Cancer. 2012;12:284.

Baraki H, Zinne N, Wedekind D, Meier M, Bleich A, Glage S, Hedrich HJ, Kutschka I, Haverich A. Magnetic Resonance Imaging of Soft Tissue Infection with Iron Oxide Labeled Granulocytes in a Rat Model. PLoS One. 2012;7(12):e51770.

Sommer T, Meier M, Bruns F, Pabst R, Breves G, Hadamitzky C. Quantification of Lymphedema in a Rat Model by 3d-Active Contour Segmentation by Magnetic Resonance Imaging. Lymphat Res Biol. 2012;10(1):25-9.

Witte F, Kalla K, Meier M. Magnesium corrosion associated gas cavity formation imaged in vivo using MRI. Annual Meeting of the Swiss Society for Biomaterials. Eur Cell and Mater. 2012(23)Suppl. 2, 2012

Froese N, Kattih B, Grund A, Meier M, Hilfiker-Kleiner D, Bauersachs J, Heineke J. P1671 - Protektive Effekte des endothelialen Transkriptionsfaktors GATA2 auf das Myokard nach pathologischer Druckbelastung. Kreislaufforschung DGfK-H-u. 78. Jahrestagung der Deutsche Gesellschaft für Kardiologie- Herz- und Kreislaufforschung vom 11. bis 14. April 2012 in Mannheim. Clin Res Cardiol. 2012;101(0):1.

Saghafia M, Limbourg A, Korf-Klingebiel M, Woiterski J, Meier M, Wollert KC, Limbourg F. P1681 - A vascular cause of dilated cardiomyopathy? Control of cardiac homeostasis and function by microvascular Notch signalling. Kreislaufforschung DGfK-H-u. 78. Jahrestagung der Deutsche Gesellschaft für Kardiologie- Herz- und Kreislaufforschung vom 11. bis 14. April 2012 in Mannheim. Clin Res Cardiol. 2012;101(0):1.

2011

Bankstahl JP, Bankstahl M, Kuntner C, Stanek J, Wanek T, Meier M, Ding XQ, Muller M, Langer O, Loscher W. A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier. J Neurosci. 2011;31(24):8803-11.

2010

Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Karch R, Brauner R, Meier M, Ding X, Muller M, Loscher W, Langer O. Dose-Response Assessment of Tariquidar and Elacridar and Regional Quantification of P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Using (R)-[(11)C]Verapamil Pet. Eur J Nucl Med Mol Imaging. 2010;37(5):942-53.

2008

Meier M. Artifacts or Art in Fact: Useful susceptibility effects in MRI. In: Biomagnetism: Interdisciplinary Research and Exploration, Suppl. Kakigi R, Yokosawa K, Kuriki S. (Eds.), Hokkaido University Press, 2008, ISBN 978-4-8329-0355-5.

2007

Dreher W, Meier M, Erhard P, Leibfritz D. On the use of spin echo and stimulated echo based functional MRI sequences. In: Topics in Advanced Imaging. Herrmann M, Thiel C. (Eds.), Oldenburg, 2007, 51-4. ISBN: 978-3

test
Diese Webseite verwendet Cookies und die Webanalyse-Software Google Analytics. Klicken Sie hier für weitere Informationen zum Datenschutz.
Einverstanden