Arbeitsgruppenleiter

Büttner, Falk

Büttner, Falk , Prof. Dr. rer. nat.

Arbeitsgruppenleiter

REBIRTH Unit Stem Cell Glycomics and Proteomics


Biography / About

Date of Birth:December, 1978
Function:W1 Professor

Education:

10/1999 – 03/2005Diploma study program of biochemistry at the University of Hannover; Diploma in Biochemistry
11/2004 – 09/2007Ph.D. thesis at the Department of Infectious Diseases, Institute for Microbiology, University of Veterinary Medicine Hannover (supervisor: Prof. G.-F. Gerlach); degree: Dr. rer. nat.; grade summa cum laude

Academic appointments and Research posts:

10/2007 – 06/2009Postdoctoral fellow, Department of Infectious Diseases, Institute for Microbiology, University of Veterinary Medicine Hannover (supervisor: Prof. G.-F. Gerlach)
07/2009 – 09/2011Postdoctoral fellow, Institute for Cellular Chemistry, Hannover Medical School (MHH) (supervisor: Prof. Gerady-Schahn)
Since 10/2011Junior professor (W1), Institute for Cellular Chemistry, MHH
Since 11/2012Leader of the research unit “Stem Cell Glycomics and Proteomics” in the frame of the DFG-cluster of excellence REBIRTH

Other professional activities:

  • Ad hoc reviewer for the DFG and Deutsche Krebshilfe
  • Regular reviewer in various journals (e.g., Proteomics, Journal of Cellular and Molecular Medicine, PLOS ONE, Stem Cells and others)
  • Member of German Stem Cell Network (GSCN)
  • Member of Gesellschaft für Biochemie und Molekularbiologie (GBM)
  • Member of The American Society for Biochemistry and Molecular Biology (ASBMB)

Awards and Prizes:

2004 - 2007Scholarship of the DFG (Graduate School Mucosal Host-Pathogen Interactions)

Major research interests:

  • Glycobiology
  • Stem cell biology
  • Mass spectrometry-based analytics (glycomics, glycoproteomics, proteomics)

Selected Publications:

  1. Konze,S.A., Cajic,S., Oberbeck,A., Hennig,R., Pich,A., Rapp,E., and Buettner,F.F. (2017). Quantitative assessment of sialo-glycoproteins and N-glycans during cardiomyogenic differentiation of human induced pluripotent stem cells. ChemBioChem. DOI: 10.1002/cbic.201700100.
  2. Konze,S.A., Werneburg,S., Oberbeck,A., Olmer,R., Kempf,H., Jara-Avaca,M., Pich,A., Zweigerdt,R., and Buettner,F.F. (2017). Proteomic analysis of human pluripotent stem cell cardiomyogenesis revealed altered expression of metabolic enzymes and PDLIM5 isoforms. J Proteome Res. 16, 1133-1149.
  3. Shcherbakova,A., Tiemann,B., Buettner,F.F., and Bakker,H. (2017). Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Proc Natl Acad Sci U S A. 114, 2574-2579.
  4. Kempf,H., Olmer,R., Haase,A., Franke,A., Bolesani,E., Schwanke,K., Robles-Diaz,D., Coffee,M., Göhring,G., Dräger,G., Pötz,O., Joos,T., Martinez-Hackert,E., Haverich,A., Buettner,F.F., Martin,U., and Zweigerdt,R. (2016). Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nat Commun. 7, 13602.
  5. Werneburg,S., Buettner,F.F., Erben,L., Mathews,M., Neumann,H., Mühlenhoff,M., and Hildebrandt,H. (2016). Polysialylation and shedding of E-selectin ligand-1 and neuropilin-2 by microglia and macrophages. Glia 64, 1314-1330.
  6. Thiesler,C.T., Cajic,S., Hoffmann,D., Thiel,C., van Diepen,L., Hennig,R., Sgodda,M., Weibetamann,R., Reichl,U., Steinemann,D., Diekmann,U., Huber,N.M., Oberbeck,A., Cantz,T., Kuss,A.W., Korner,C., Schambach,A., Rapp,E., and Buettner,F.F. (2016). Glycomic characterization of induced pluripotent stem cells derived from a patient suffering from phosphomannomutase 2 congenital disorder of glycosylation (PMM2-CDG). Mol. Cell Proteomics. 15, 1435-1452.
  7. Baumann,A.M., Bakkers,M.J., Buettner,F.F., Hartmann,M., Grove,M., Langereis,M.A., de Groot,R.J., and Muhlenhoff,M. (2015). 9-O-Acetylation of sialic acids is catalysed by CASD1 via a covalent acetyl-enzyme intermediate. Nat. Commun. 6, 7673.
  8. Werneburg,S., Buettner,F.F., Mühlenhoff,M. and Hildebrandt,H. Polysialic acid modification of the synaptic cell adhesion molecule SynCAM 1 in human embryonic stem cell-derived oligodendrocyte precursor cells (2015). Stem Cell Res. 14, 339-346.
  9. Konze,S.A., van Diepen,L., Schroder,A., Olmer,R., Moller,H., Pich,A., Weissmann,R., Kuss,A.W., Zweigerdt,R., and Buettner,F.F. (2014). Cleavage of E-cadherin and beta-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells. Mol. Cell Proteomics. 13, 990-1007.
  10. Buettner,F.F., Ashikov,A., Tiemann,B., Lehle,L., and Bakker,H. (2013). C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats. Mol. Cell 50, 295-302.


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