Arbeitsgruppenleiter

Vogel, Arndt

Vogel, Arndt, Prof. Dr. med.

Arbeitsgruppenleiter

REBIRTH Unit Molecular Mechanisms of Endogenous Liver Regeneration Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School


Biography / About

Date of Birth:March, 1971
Function:Senior consultant, Research Group leader

Education:

04/1991 - 11/1997Medical School, University of Göttingen
1997Medical Approbation by the State of Lower Saxony, Germnay
12/1999Doctor of Medicine, Dept. Of Clinical Chemistry, University of Göttingen, Prof. Dr. med. Michael Oellerich
02/2008Board Certification “Gastroenterology”
10/2009Venia legendi, Internal Medicine, Hannover Medical School (MHH), Prof. M.P. Manns
06/2010Board Certification “Internal Medicine”

Academic appointments and Research posts:

04/1998 - 12/1999Internal Medicine Internship, Dept. of Gastroenterology, Zentral Krankenhaus Mitte, Bremen, Prof. Dr. Arnold
01/2000 - 04/2002Internal Medicine Fellowship, Dept. of Gastroenterology, MHH, Prof. M. P. Manns
05/2002 - 10/2004Postdoctoral Fellow (sponsored by the German Research Foundation), Oregon Health and Science University, Portland, Oregon, Prof. Dr. med. M. Grompe
Since 2004Research Group Leader
11/2004 - 10/2009Internal Medicine Fellowship, Dept. of Gastroenterology, MHH, Prof. M.P. Manns
Since 10/2009Consultant in Internal Medicine (Oberarzt), Dept. of Gastroenterology, MHH, Prof. M. P. Manns
06/2012Associate (W2) Professor for Gastrointestinal Oncology, Dept. of Gastroenterology, MHH, Prof. M. P. Manns

Awards and Prizes:

2005 - 2010Max-Eder Fellow, German Cancer Aid
2016AIO Wissenschaftspreis

Major research interests:

  • Chronic liver diseases
  • Liver regeneration
  • Hepatocyte Transplantation
  • Apoptosis
  • Liver Cancer

Selected Publications:

  1. J Endig, LE Buitrago-Molina, S Marhenke, F Reisinger, A Saborowski, J Schütt, F Limbourg, C Könecke, A Schreder, A Michael, AC Misslitz, ME Healy, R Geffers, T Clavel, K Unger, M Finegold, A Weber, MP Manns, T Longerich, M Heikenwälder and A Vogel. Dual role of the adaptive immune system in liver injury and hepatocellular carcinoma development. Cancer Cell 2016; 27:S1535-6108
  2. J Orlik, S Schüngel, LE Buitrago-Molina, R Geffers, J Endig, S Marhenke, K Lobschat, S Rössler, B Goeppert, MP Manns, A Gross and A Vogel. The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice. Hepatology 2015; 62(3):816-28
  3. S Marhenke, LE Buitrago-Molina, J Endig, J Orlik, N Schweitzer, T Longerich, R Geffers, A Sánchez Muñoz, C Dorrell, S Katz, A Lechel, H Weng, T Krech, U Lehmann, S Dooley, KL Rudolph, MP Manns and A Vogel. p21 promotes Liver Regeneration and Hepatocarcinogenesis in Chronic Cholestatic Liver Injury. Gut, 2014 Sep;63(9):1501-12
  4. E Horwitz, I Stein, M Andreozzi, J Nemeth, A Shoham, O Pappo, N Schweitzer, L Tornillo, N Kanarek, L Quagliata, F Zreik, RM Porat, R Finkelstein, H Reuter, R Koschny, T Ganten, C Mogler, O Shibolet, J Hess, K Breuhahn, M Grunewald, P Schirmacher, A Vogel, L Terracciano, P Angel, Y Ben-Neriah & E Pikarsky. Human and mouse VEGFA-amplified hepatocellular carcinomas are highly sensitive to sorafenib treatment. Cancer Discovery, 2014; 4(6):730-43
  5. T Wuestefeld, M Pesic, T Longerich, TW Kang, T Yevsa, D Dauch, A Potapova, Ina Rittelmeier, M Jarek, R Geffers, M Scharfe , F Klawonn, NP Malek, P Schirmacher, M Ott, A Vogel, MP Manns and L Zender. A direct in vivo RNAi screen identifies MKK4 as a key regulator of liver regeneration. Cell, 2013; 11;153(2):389-401
  6. LE Buitrago-Molina, S Marhenke, T Longerich, AE Boukouris, R Geffers, B Guigas, MP Manns and A Vogel. The degree of liver injury determines the role of p21 in liver regeneration and hepatocarcinogenesis Livers. Hepatology, 2013; 58(3):1143–1152
  7. S Schüngel, LE Buitrago-Molina, P Nalapareddy, M Lebofsky, MP Manns, H Jaeschke, A Gross, and A Vogel. The Strength of the Fas Ligand Signal Determines Whether Hepatocytes Act as Type 1 or Type 2 Cells in Murine Livers. Hepatology, 2009; 50(5):1558-66
  8. LE Buitrago-Molina, D Pothiraju, J Lamlè, S Marhenke, U Kossatz, K Breuhahn, MP Manns, N Malek and A Vogel. mTOR inhibition impairs proliferation of hepatocytes with DNA damage during chronic liver injury thereby delaying liver tumor development. Hepatology, 2009; 50(2):500-509
  9. JE Aslan, HY, DM Williamson, J Endig, RT Youker, L Thomas, H Shu, Y Du, RL Milewski, MH Brush, A Possemato, K Sprott, H Fu, KD Greis, DN Runckel, A Vogel and G Thomas. Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis. Molecular Cell, 2009; 14;34(4):497-509
  10. H Willenbring, AD Sharma, A Vogel, AY Lee, A Rothfuss, Z Wang, M Finegold and M Grompe. Loss of p21 Permits Carcinogenesis from Chronically Damaged Liver and Kidney Epithelial Cells Despite Unchecked Apoptosis.Cancer Cell, 2008; 14(1):59-67


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