Arbeitsgruppenleiter

Korossis, Sotrios

Korossis, Sotrios, PhD

Arbeitsgruppenleiter

REBIRTH Unit Biohybrid Lung, Klinik für Herz-, Thorax-, Transplantations- und Gefäßchirurgie (HTTG) Medizinische Hochschule Hannover


Biography / About

Date of Birth:August, 1976
Function:Director of Biomedical Engineering
Group Leader Biohybrid Lung
Group Leader Cardiopulmonary Regenerative Engineering

Education:

1993 - 1996BEng Mechanical Engineering, Queen Mary University of London
1996 - 1997PgDip Bioengineering, University of Strathclyde
1998 - 2001PhD Biomedical Engineering, University of Leeds

Academic appointments and Research posts:

2001 - 2004Postdoctoral Research Fellow, School of Mechanical Engineering, University of Leeds
2004 - 2006Senior Research Fellow, School of Mechanical Engineering, University of Leeds
2006 - 2012Advanced Research Fellow of the Engineering & Physical Sciences Research Council (EPSRC), School of Mechanical Engineering, University of Leeds
2006 - 2012Lecturer (EPSRC/HEFCE-funded), School of Mechanical Engineering, University of Leeds
Since 2012Director of Biomedical Engineering, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School (MHH)
Since 2014Group Leader Biohybrid Lung and Cardiopulmonary Regenerative Engineering, Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, MHH

Other professional activities:

2013 - 2017Coordinator of Marie Skłodowska-Curie Initial Training Network TECAS-ITN (Tissue Engineering Solutions for Cardiovascular Surgery)

Memberships:

Since 2005Society for Heart Valve Disease
Since 2006British Standards Instirute Regenerative Medicine RGM/1 Committee
Since 2006Engineering & Physical Sciences Research Council Peer Review College
Since 2007Tissue Engineering and Regenerative Medicine International Society
Since 2010Society for Biomaterials
Since 2010International Society of Biomechanics
Since 2013German Society of Biomedical Engineering

Editorships:

  • Guest Editor Journal of Biomechanics
  • Journal of Medical Engineering
  • Journal of Biomaterials and Tissue Engineering
  • Journal of Synthetic Biology

Major research interests:

  • Biohybrid organs
  • Cardiovascular tissue engineering
  • Computational modelling
  • Biomechanics
  • Haemodynamics
  • Tissue engineering bioreactors

Peer Review:

Acta Biomaterialia, Biomaterials, Nature Methods, Journal of Nanoscience and nanotechnology, Journal of Biomechanics, Medical Engineering and Physics, Tissue Engineering, European Surgical Research, Journal of Biomedical Materials Research, Journal of Heart Valve Disease, Medical Research Council (UK), Biotechnology and Biological Sciences Research Council (UK), Engineering & Physical Sciences Research Council (UK).

Selected Publications:

  1. Granados M, Morticelli L, Andriopoulou S, Kalozoumis P, Pflaum M, Iablonskii P, Glasmacher B, Harder M, Hegermann J, Wredel C, Tudorache I, Cebotari S, Hilfiker R, Haverich A, Korossis S. Development and characterization of a porcine mitral valve scaffold for tissue engineering. J Cardiovasc Transl Res. 2017 May 1. doi: 10.1007/s12265-017-9747-z. [Epub ahead of print].
  2. Pflaum M, Kühn-Kauffeldt M, Schmeckebier S, Dipresa D, Chauhan K, Wiegmann B, Haug R, Schein J, Haverich A, Korossis S. Endothelialization and characterization of TiO2-coated gas-exchange membranes for application in the bioartificial lung. Acta Biomater. 2017 Mar 1;50:510-521
  3. Marino M, Korossis S. Cardiovascular biomechanics in health & disease. J Biomech. 2016;49(12):2319-20.
  4. Joda A, Jin Z, Summers J, Haverich A, Korossis S. Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress-strain distribution of the aortic valve. J Biomech. 2016;49(12):2502-12.
  5. Wiegmann B, von Seggern H, Höffler K, Korossis S, Dipresa D, Pflaum M, Schmeckebier S, Seume J, Haverich A. Developing a biohybrid lung - sufficient endothelialization of poly-4-methly-1-pentene gas exchange hollow-fiber membranes. J Mech Behav Biomed Mater. 2016;60:301-311
  6. Nicholas R, Morticelli L, Jin Z, Ingham E, Korossis S. Regional biomechanical and histological characterization of the mitral valve apparatus: implications for mitral repair strategies. J Biomech. 2016;49(12):2491-501.
  7. Katsimpoulas M, Morticelli L, Michalopoulos E, Gontika I, Stavropoulos-Giokas C, Kostakis A, Haverich A, Korossis S. Investigation of the biomechanical integrity of decellularized rat abdominal aorta. Transplant Proc. 2015;47(4):1228-33.
  8. Wiegmann B, Figueiredo C, Gras C, Pflaum M, Schmeckebier S, Korossis S, Haverich A, Blasczyk R. Prevention of rejection of allogeneic endothelial cells in a biohybrid lung by silencing HLA-class I expression. Biomaterials. 2014;35(28):8123-33.
  9. Morticelli L, Roberts N, Thomas D, Ingham E, Korossis S. Investigation of the suitability of decellularised porcine pericardium in mitral valve reconstruction. J Heart Valve Dis. 2013;22(3):340-53.
  10. Korossis S, Bolland F, Southgate J, Ingham E, Fisher J. Regional biomechanical and histological characterisation of the passive porcine urinary bladder: Implications for augmentation and tissue engineering strategies. Biomaterials. 2009;30(2):266-275.


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