REBIRTH Mitglieder

Sodeik, Beate

Sodeik, Beate, Prof. Dr. rer. nat.

Arbeitsgruppenleiter

REBIRTH Unit Automated and quantitative microscopy of intracellular trafficking

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

Sodeik.Beate(at)mh-hannover.de

Biography / About

Date of Birth:November, 1963
Function:Professor for Cell Biology of Viral Infections

Education:

1984Interim examionation (vordiplom) in Biology; Genetics, Microbiology, Zoology, Botany, Chemistry, Physics, Rheinische Friedrich-Wilhelms University, Bonn, Germany
1988Diplom in Biology; Focus on Cell Biology, Zoology and Physics, Rheinische Friedrich-Wilhelms University, Bonn, Germany
1993Dr. rer. nat. in Biology; Focus on Cell Biology, Virology and Botany Ruprecht-Karls-Universität Heidelberg, Germany
2002Post-doctoral lecturing qualification (habilitation) in Biochemistry, Hannover Medical School (MHH)

Academic appointments and Research posts:

1986 - 1988Teaching Assistant, Institute of Cell Biology, University Bonn
1988 - 1989Visiting Scholar, College Physicians & Surgeons, Columbia University, USA
1989 - 1993PhD, Cell Biology, European Molecular Biology Laboratory, Heidelberg
1993 - 1997Postdoc & Research Associate, School of Medicine, Yale University, USA
1997 - 2002Assistent Professor, Institute of Biochemistry, MHH
2002 - 2007Associate Professor, Institute of Virology, MHH
Since 2007Professor for Cell Biology of Viral Infections

Other professional activities:

1998 - 2004Founding and Steering Committee DFG Graduate School GRK 745 Mucosal Pathogen-Host Interactions
2001 - 2004Founder and Chair, Study Group Cell Biology, Gesellschaft für Virologie
2001 and 2004Chair, EMBO Workshop on the Cell Biology of Viral Infections
2007 - 2017Member, MHH Senate Commission on Research (Forschungskommission)
2009 - 2017Steering Committee DFG Collaborative Research Centre 900, Chronic Infections: Microbial persistence and its control
Since 2002Person in Charge, Module Virology, MSc Biomedicine + MSc Biochemistry
Since 2011Scientific Advisory Board, IHW - International Herpesvirus Workshop
Since 2015Member, Senatsausschuß Wettbewerb (SAW), Leibniz-Gemeinschaft
Since 2016Vice president, Gesellschaft für Virologie
Since 2016Member, DFG Fachkollegium Mikrobiologie, Virologie und Immunologie

Awards and Prizes:

1988 - 1989DAAD Fellow (German Academic Exchange Service)
1989 - 1993EMBL Predoctoral Fellow
1993 - 1995EMBO Postdoctoral Fellow

Major research interests:

  • Cell Biology of Viruses and Viral Vectors
  • Neurobiology and Immunology of Alphaherpesviruses
  • Regeneration upon viral infections
  • In vivo imaging of viral infection and subcellular trafficking

Furthermore:

Supervisor of 21 PhD, 4 MSc, 17 Diploma and 3 BSc theses.
More than 60 peer-reviewed publications; h-index 33; 5,500 citations (Google Scholar, 05/2017)

Selected Publications:

  1. Ashford (joint first), Hernandez (joint first), Greco (joint first), Buch, Sodeik, Cristea (corresponding), K Grünewald (corresponding), A Shepherd (corresponding) & M Topf (corresponding). HVint: A strategy for identifying novel protein-protein interactions in herpes simplex virus type 1. Molecular Cell Proteomics 2016, 15:2939-2953.
  2. Ivanova, Buch, Döhner, Pohlmann, Binz, Sandbaumhüter, Prank, Bauerfeind (corresponding) & Sodeik (corresponding). Conserved tryptophan motifs in the large tegument protein pUL36 are required for efficient secondary envelopment of Herpes Simplex Virus. Journal of Virology 2016, 90:5368-5383. Cover Image.
  3. Anderson (joint first), Savulescu (joint first), Rudolph, Schipke, Cohen, Ibiricu, Rotem, Grünewald, Sodeik (corresponding) & Harel (corresponding). Specific targeting of Herpes Simplex Virus Capsids to Nuclear Pores in a cell-free nuclear reconstitution system. Traffic 2014, 15:1266-1281. Cover Image.
  4. Devadas, Koithan, Diestel, Prank, Sodeik (corresponding) & Döhner (corresponding). Herpes Simplex Virus Internalization into Epithelial Cells requires Na+/H+ Exchangers and p-21-activated Kinases but neither Clathrin- nor Caveolin-mediated Endocytosis. Journal of Virology 2014, 88:13378-13395.
  5. Rode, Döhner, Binz, Glass, Strive, Bauerfeind & Sodeik. Uncoupling uncoating of Herpes Simplex Virus genomes from their nuclear import and gene expression. Cover Image and Spotlight feature of Journal of Virology 2011, 85:4271-4283.
  6. Radtke, Kieneke, Wolfstein, Michael, Steffen, Scholz, Karger & Sodeik. Plus- and minus-end directed microtubule motors bind simultaneously to Herpes Simplex Virus capsids using different inner tegument structures. PLoS Pathogens 2010, 6(7): e1000991.
  7. Roos (joint first), Radtke (joint first), Kniesmeijer, Geertsema, Sodeik (corresponding) & Wuite (corresponding). Scaffold expulsion and genome packaging trigger stabilization of Herpes Simplex Virus capsids. Proceedings of the National Academy of Sciences USA 2009, 106:9673-78.
  8. Nagel, Döhner, Fathollahy, Strive, Borst, Messerle & Sodeik. Nuclear egress and envelopment of herpes simplex virus capsids analyzed with dual-color fluorescence HSV1(17+). Journal of Virology 2008, 82:3109-24.
  9. Sodeik (corresponding), Ebersold & Helenius. Microtubule mediated transport of incoming Herpes Simplex Virus I capsids to the nucleus. Journal of Cell Biology 1997, 136:1007-1021.
  10. Sodeik, Doms, Ericsson, Hiller, Machamer, van't Hof, van Meer, Moss & Griffiths. Assembly of vaccinia virus: Role of the intermediate compartment between the endoplasmic reticulum and the Golgi Stack. Journal of Cell Biology 1993, 121:521-541.


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