REBIRTH Mitglieder

Heineke, Jörg

Heineke, Jörg, Prof. Dr. med.

Arbeitsgruppenleiter

REBIRTH Myocardial Cellular Crosstalk and Gene Therapy

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

Heineke.Joerg(at)mh-hannover.de

Biography / About

Date of Birth:January, 1974
Function:W2 Heisenberg Professor, Group Leader

Education:

1993 - 2000Medical School, Hannover Medical School (MHH)
2001Medical Doctor Degree (summa cum laude)
2000 - 2003Clinical fellow and member of the research group “Molecular and translational Cardiology” (Groupleader: Prof. Dr. K. C. Wollert); MHH
2004 - 2007Postdoctoral Fellow, Department of Molecular Cardiovascular Biology, Cincinnati Children´s Hospital, USA (Groupleader: Prof. Dr. J. D. Molkentin)
2011Post-doctoral lecturing qualification (habilitation) for “Molecular Cardiology”

Academic appointments and Research posts:

2007 - 2012Junior research group leader, Cluster of Excellence Rebirth
Since 2012Heisenberg professorship for Experimental Cardiology

Awards and Prizes:

2011Sir Hans Krebs Prize (endowed by Ernst-August Schrader)
2012Heisenberg Professorship from the German Research Foundation (DFG)

Major research interests:

  • Molecular mechanisms of heart failure
  • Transcription factor
  • Intercellular communication
  • Cardiac hypertrophy
  • (Genetic) mouse models

Selected Publications:

  1. Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO Mol Med. 2017 Feb;9(2):265-279. doi: 10.15252/emmm.201606602
  2. Appari M*, Breitbart A*, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Müller OJ, Bauersachs J, Heineke J. C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circ Res. 2017 Jan 6;120(1):66-77.
  3. Zwadlo C*, Schmidtmann E*, Szaroszyk M*, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J. Anti-androgenic therapy with finasteride attenuates cardiac hypertrophy and left ventricular dysfunction. Circulation. 2015 Mar 24;131(12):1071-81.
  4. Breitbart A*, Scharf GM*, Duncker D*, Widera C, Gottlieb J, Vogel A, Schmidt S, Brandes G, Heuft HG, Lichtinghagen R, Kempf T, Wollert KC, Bauersachs J, Heineke J. Highly specific detection of myostatin prodomain by an immunoradiometric sandwich assay in serum of healthy individuals and patients. PLoS One. 2013 Nov 15;8(11):e80454.
  5. Froese N*, Kattih B*, Breitbart A, Grund A, Geffers R, Molkentin JD, Kispert A, Wollert KC, Drexler H, and Heineke J. GATA6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor {beta}/Activin Receptor-like Kinase 5 Signaling. J Biol Chem 2011; 286: 5680-5690.
  6. Heineke J§. Wag the Dog: How Endothelial Cells Regulate Cardiomyocyte Growth. Arterioscler Thromb Vasc Biol. 2012;32:545-547.
  7. Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD§. CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010; 16 (8):872-879
  8. Heineke J, Auger-Messier M*, Xu J, Sargent M, York A, Welle S, Molkentin JD. Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. Jan 26 2010; 121(3): 419-25
  9. Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD. Calcineurin protects the heart in a murine model of dilated cardiomyopathy. J Mol Cell Cardiol. 2010; 48(6):1080-1087.
  10. Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Cromblehol TM, Molkentin JD. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest. Nov 2007;117(11):3198-3210.


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