REBIRTH Mitglieder

Gruh, Ina

Gruh, Ina, Prof. Dr. rer. nat.

Arbeitsgruppenleiter

REBIRTH Unit Myocardial Tissue Engineering

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

Gruh.Ina(at)mh-hannover.de

Biography / About

Date of Birth:January, 1975
Function:Research group leader

Education:

1994Higher secondary education (Abitur, German A-Levels), Gymnasium Westerstede
1995 - 1998Undergraduate studies in Biochemistry, Leibniz University Hannover
1998 - 2001Graduate studies in Biochemistry, Leibniz University Hannover
08/2001Diploma in Biochemistry, Leibniz University Hannover
2001 - 2005PhD thesis, Leibniz Research Laboratories for Biotechnology and Artificial Organs, Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School (MHH)
2005Dr. rer. nat. in Biochemistry, Leibniz University Hannover
2014Post-doctoral lecturing qualification (Habilitation), MHH

Academic appointments and Research posts:

2001 - 2005Doctoral dissertation research fellow, MHH
2005 - 2007Post-doctoral research fellow, MHH
Since 2007Research Group Leader, MHH

Other professional activities:

  • Reviewer for DFG
  • Reviewer for The American Journal of Physiology - Cell Physiology, Acta Biomaterialia, Biomaterials, Journal of Molecular and Cellular Cardiology, Annals of Anatomy

Awards and Prizes:

02/2001Graduate Scholarship, Hannover Medical School
2006Travel Allowance, Boehringer Ingelheim Fonds

Major research interests:

  • Tissue Engineering
  • Stem Cell Biology
  • Biomaterials
  • Bioreactors
  • Cardiac Development

Furthermore:

Member of the German Society for Stem Cell Research (GSZ), the German Stem Cell Network (GSCN), and the International Society for Stem Cell Research (ISSCR)

Selected Publications:

  1. Rojas SV, Kensah G, Rotaermel A, Baraki H, Kutschka I, Zweigerdt R, Martin U, Haverich A, Gruh I*, Martens A*. Transplantation of purified iPSC-derived Cardiomyocytes in myocardial infarction. PLOS ONE accepted. *contributed equally
  2. Dibbert N, Krause A, Rios-Camacho JC, Gruh I, Kirschning A, Dräger G. A Synthetic Toolbox for the In Situ Formation of Functionalized Homo- and Heteropolysaccharide-Based Hydrogel Libraries. Chemistry. 2016 Nov 16. doi: 10.1002/chem.201603748. [Epub ahead of print]
  3. Kempf, H*, Olmer R*, Kropp C, Rückert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. (2014) "Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture." Stem Cell Reports 3(6):1132-46.
  4. Kempf, H*, Olmer R*, Kropp C, Rückert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. (2014) "Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture." Stem Cell Reports 3(6):1132-46
  5. Kensah G*, Roa Lara A*, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Dräger G, Ochs M, Haverich A, Gruh I#, Martin U#. 2013. Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro. European Heart Journal 34, no. 15:1134.
  6. Dahlmann J*, Krause A*, Möller L, Kensah G, Möwes M, Diekmann A, Martin U, Kirschning A, Gruh I#, Dräger G#. 2013. Fully defined in situ cross-linkable alginate and hyaluronic acid hydrogels for myocardial tissue engineering. Biomaterials 34, no. 4:940.
  7. Dahlmann J*, Kensah G*, Kempf H, Skvorc D, Gawol A, Elliott DA, Dräger G, Zweigerdt R, Martin U, Gruh I. 2013. The use of agarose microwells for scalable embryoid body formation and cardiac differentiation of human and murine pluripotent stem cells. Biomaterials 34, no. 10:2463.
  8. Emmert MY, Emmert LS, Martens A, Ismail I, Schmidt-Richter I, Gawol A, Seifert B, Haverich A, Martin U, Gruh I. Higher frequencies of BCRP+ cardiac resident cells in ischaemic human myocardium. European Heart Journal 2012 Jun 26. [Epub ahead of print]
  9. Kensah G*, Gruh I*, Viering J, Schumann H, Dahlmann J, Meyer H, Skvorc D, Bär A, Akhyari P, Heisterkamp A, Haverich A, Martin U. 2011. A novel miniaturized multimodal bioreactor for continuous in situ assessment of bioartificial cardiac tissue during stimulation and maturation. Tissue Eng Part C Methods 17, no. 4:463.
  10. Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR and Martin U. Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell. 2009;5:434-41.
  11. Gruh I, Beilner J, Blomer U, Schmiedl A, Schmidt-Richter I, Kruse ML, Haverich A and Martin U. No evidence of transdifferentiation of human endothelial progenitor cells into cardiomyocytes after coculture with neonatal rat cardiomyocytes. Circulation. 2006;113:1326-34.


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