REBIRTH Mitglieder

Cantz, Tobias

Cantz, Tobias, Prof. Dr. med.

Arbeitsgruppenleiter

REBIRTH Unit Translational Hepatology and Stem Cell Biology

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

Cantz.Tobias(at)mh-hannover.de

Biosketch:

T. Cantz (*1972), MD, is W2 professor for ‘Translational Hepatology and Stem Cell Biology’ at MHH. He is executive board member of the cluster of excellence REBIRTH and head of the work groups ‘public outreach’ and ‘ethical, legal, and social aspects’ of the German Stem Cell Network (GSCN). Research of T. Cantz focuses on induced pluripotent stem cells, their differentiation into hepatic and biliary derivatives, development of iPSC-based disease models and gene engineering approaches, as well as exploring direct reprogramming of myofibroblasts into hepatic cells as therapeutic strategy.

Biography / About

Date of Birth:July, 1972
Function:Associate (W2) Professor for ‘Translational Hepatology and Stem Cell Biology’, Department of Gastroenterology, Hepatology, and Endocrinology, Hannover Medical School (MHH)

Education:

1993 - 2000Ruprecht Karls University of Heidelberg, Germany: Medicine
1997 - 1999Doctorate: Department of Tumorbiochemistry (Prof. D. Keppler), German Cancer Research Center (DKFZ) Heidelberg, Germany.
12/2012Post-doctoral lecturing qualification (Habilitation): Venia legendi for ‘Regenerative Medicine’

Academic appointments and Research posts:

2000 - 2004 Physician and staff scientist Department of Gastroenterology, Hepatology and Endocrinology, MHH (Prof. M. Manns)
2004 - 2005 Fellowship, Max Planck Institute (MPI) for Molecular Biomedicine, Münster, Germany
2005 - 2007 Staff scientist, MPI for Molecular Biomedicine, Münster
Since 2008Head of the MPI-associated Research Group ‘Translational Hepatology and Stem Cell Biology’ in the REBIRTH Cluster of Excellence, MHH
Since 2014Associate Professor of Translational Hepatology and Stem Cell Biology, MHH

Other professional activities:

2005 - 2008Member of the work group ‘gene ethics’ of the ‘Evangelische Kirche von Westfalen’
Since 2007Coordinator of www.zellux.net (web-based teaching material for high school pupils on ethics and therapeutic perspectives of human embryonic stem cells)
Since 2012Member of the Steering Committee of the REBIRTH Cluster of Excellence
Since 2013Coordinator of the work group ‘Outreach Activities’ in the German Stem Cell Network

Awards and Prizes:

10/2011Pro Scientia Prize of the Eckhart-Buddecke-Foundation
05/2013Founding Member of the German Stem Cell Network (gscn.org)

Major research interests:

  • Hepatic cell biology
  • Transplantation medicine
  • Stem cell biology
  • Genome engineering
  • Bioethics

Selected Publications:

  1. Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell. 2016. 18(6):797-808. DOI: 10.1016/j.stem.2016.01.010.
  2. Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p mimic inhibits acute liver failure. Nat Commun. 2016. 7:11916. DOI: 10.1038/ncomms11916.
  3. Möbus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-199a-5p inhibition enhances the liver repopulation ability of human embryonic stem cell-derived hepatic cells. J Hepatol. 2015. 62:101-10. DOI: 10.1016/j.jhep.2014.08.016.
  4. Kim J, Kim KP, Lim KT, Lee SC, Yoon J, Song G, Hwang SI, Schöler HR, Cantz T, Han DW. Generation of integration-free induced hepatocyte-like cells from mouse fibroblasts. Scientific reports. 2015. 5:15706. DOI: 10.1038/srep15706.
  5. Eggenschwiler R, Moslem M, Fraguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wahner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Scientific reports. 2016. 6:38198. DOI: 10.1038/srep38198.
  6. Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Schöler HR, Cantz T. Sustained knockdown of a disease-causing gene in patient-specific induced pluripotent stem cells using lentiviral vector-based gene therapy. Stem cells translational medicine. 2013. 2(9):641-54. DOI: 10.5966/sctm.2013-0017. DOI: 10.5966/sctm.2013-0017
  7. Sgodda M, Möbus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T. Improved hepatic differentiation strategies for human induced pluripotent stem cells. Curr Mol Med. 2013. 13(5):842-55. DOI: 10.2174/1566524011313050015
  8. Sharma AD, Narain N, Händel EM, Iken M, Singhal N, Cathomen T, Manns MP, Schöler HR, Ott M, Cantz T. MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology. 2011. 53(5):1651-61. DOI: 10.1002/hep.24243.
  9. Wu G, Gentile L, Do JT, Cantz T, Sutter J, Psathaki K, Ara XfZ-BMJ, Ortmeier C, Schöler HR. Efficient Derivation of Pluripotent Stem Cells from siRNA-Mediated Cdx2-Deficient Mouse Embryos. Stem Cells Dev. 2011. 20(3):809-18. DOI: 10.1089/scd.2010.0128.
  10. Cantz T, Key G, Bleidissel M, Gentile L, Han DW, Brenne A, Schöler HR. Absence of OCT4 Expression in Somatic Tumor Cell Lines. Stem Cells. 2008. 26(3):692-7. DOI: 10.1634/stemcells.2007-0657


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