REBIRTH Mitglieder

Kispert, Andreas

Kispert, Andreas, Prof. Dr. rer. nat.


REBIRTH Unit Transcriptional control of Organogenesis

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover


Biography / About

Date of Birth:October, 1963
Function:Full (W3) Professor for the Developmental Biology of Vertebrates, Independent Group Leader


1983 - 1989Studies in Biochemistry at the University of Tübingen, Germany
1987 - 1988Scientific year at the Queen Mary College and the Middlesex Hospital and University College Medical School in London, UK
1989 - 1990Diploma thesis at the Max Planck Institute (MPI) for Developmental Biology in Tübingen, Germany
1990 - 1993Ph.D. thesis at the MPI for Developmental Biology in Tübingen

Academic appointments and Research posts:

1993 - 1994Postdoctoral fellow at the MPI for Developmental Biology in Tübingen
1994 - 1996Postdoctoral fellow in the laboratory of Professor Andrew McMahon in the Biological Laboratories at Harvard University, Cambridge, MA, USA
1997 - 2001Group leader at the MPI of Immunobiology in Freiburg, Germany
2001 - 2008Professor (C3) for Developmental Biology of Vertebrates at MHH
Since 2008 Professor (W3) for Developmental Biology of Vertebrates at MHH

Other professional activities:

Since 2009Section Editor, Development Genes and Evolution
Reviewer for DFG, German Academic Scholarship Foundation (‘Studienstiftung des deutschen Volkes’)
Canadian Research Chair and various international foundations and universities
Reviewer for Nature, Development, Developmental Biology and many other journals

Awards and Prizes:

1993Otto Hahn Medal of the Max Planck Society
1994 - 1996Fellow of the Human Science Frontier Project Organization
1996Fellow of the Max-Planck-Society
2010Ruysch Lecture, Amsterdam Medical Center

Major research interests:

  • Organogenesis
  • Transcription factos
  • Signaling pathways
  • T-box genes
  • Cell differentiation

Selected Publications:

  1. Ludtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A. Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. Dev Cell. 2016;39(2):239-53. DOI:
  2. Greulich F, Trowe MO, Leffler A, Stoetzer C, Farin HF, Kispert A. Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature. J Mol Cell Cardiol. 2016;97:140-9. DOI: 10.1016/j.yjmcc.2016.05.004.
  3. Bohnenpoll T, Feraric S, Nattkemper M, Weiss AC, Rudat C, Meuser M, Trowe MO, Kispert A. Diversification of Cell Lineages in Ureter Development. J Am Soc Nephrol. 2016. DOI: 10.1681/ASN.2016080849.
  4. Ludtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A. Tbx2 controls lung growth by direct repression of the cell cycle inhibitor genes Cdkn1a and Cdkn1b. PLoS Genet. 2013;9(1):e1003189. DOI: 10.1371/journal.pgen.1003189.
  5. Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A. Notch signaling regulates smooth muscle differentiation of epicardium-derived cells. Circ Res. 2011;108(7):813-23. DOI: 10.1161/CIRCRESAHA.110.228809.
  6. Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A. Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal. Circ Res. 2009;105(5):442-52. DOI: 10.1161/CIRCRESAHA.109.196063.
  7. Ludtke TH, Christoffels VM, Petry M, Kispert A. Tbx3 promotes liver bud expansion during mouse development by suppression of cholangiocyte differentiation. Hepatology. 2009;49(3):969-78. DOI: 10.1002/hep.22700.
  8. Christoffels VM, Grieskamp T, Norden J, Mommersteeg MT, Rudat C, Kispert A. Tbx18 and the fate of epicardial progenitors. Nature. 2009;458(7240):E8-9; discussion E-10. DOI: 10.1038/nature07916.
  9. Christoffels VM, Mommersteeg MT, Trowe MO, Prall OW, de Gier-de Vries C, Soufan AT, Bussen M, Schuster-Gossler K, Harvey RP, Moorman AF, Kispert A. Formation of the venous pole of the heart from an Nkx2-5-negative precursor population requires Tbx18. Circ Res. 2006;98(12):1555-63. DOI:
  10. Airik R, Bussen M, Singh MK, Petry M, Kispert A. Tbx18 regulates the development of the ureteral mesenchyme. J Clin Invest. 2006;116(3):663-74. DOI: 10.1172/JCI26027

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