REBIRTH Mitglieder

Hilfiker, Andres

Hilfiker, Andres, PhD


REBIRTH Unit Tissue Engineered Valves

Hannover Medical School
Carl-Neuberg-Strasse 1
30625 Hannover


Biography / About

Date of Birth:April, 1957
Function:Working group leader


1978 - 1984Studies in biology, University Zürich (UZH)
1984Diploma in Zoology, UZH
1984 - 1990PhD studies, Assistant Zoological Institut, UZH
1990Promotion Dr. phil., UZH
1990 - 1992Postdoc, Assistant Zoological Institut, UZH
1992 - 1996Postdoc, Department of Biology, Emory University, Atlanta GA, USA

Academic appointments and Research posts:

1997 - 2001Lab leader, Clinik for Cardiology, Hannover Medical School (MHH)
2002 - 2003Senior Scientist, Fa Develogen, Göttingen
Since 2005Leader Working Area „Tissue Engineering“ LEBAO, HTTG Surgery, MHH

Other professional activities:

1998Member of the German Society of Cardiology
2006Member of the German Society of Thoracic, Heart and Vascular Surgery

Major research interests:

  • Tissue engineering
  • Perfusion
  • Endothelial cells
  • Heart valves
  • Myocardium

Selected Publications:

  1. Theodoridis K, Müller J, Ramm R, Findeisen K, Andrée B, Korossis S, Haverich A, Hilfiker A. Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves. Acta Biomater. 2016 Oct 1;43:71-7.
  2. Ramm R, Niemann H, Petersen B, Haverich A, Hilfiker A. Decellularized GGTA1-KO pig heart valves do not bind preformed human xenoantibodies. Basic Res Cardiol. 2016 Jul;111(4):39.
  3. Lux M, Andrée B, Horvath T, Nosko A, Manikowski D, Hilfiker-Kleiner D, Haverich A, Hilfiker A. In vitro maturation of large-scale cardiac patches based on a perfusable starter matrix by cyclic mechanical stimulation. Acta Biomater. 2016 Jan;30:177-87
  4. Theodoridis K, Tudorache I, Calistru A, Cebotari S, Meyer T, Sarikouch S, Bara C, Brehm R, Haverich A, Hilfiker A. Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep. Biomaterials. 2015 Jun;52:221-8
  5. Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Höffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. Eur J Cardiothorac Surg. 2016 Apr;49(4):1228-38.
  6. Wang S, Oldenhof H, Goecke T, Ramm R, Harder M, Haverich A, Hilfiker A, Wolkers WF. Sucrose Diffusion in Decellularized Heart Valves for Freeze-Drying. Tissue Eng Part C Methods. 2015 Sep;21(9):922-31
  7. Andrée B, Bela K, Horvath T, Lux M, Ramm R, Venturini L, Ciubotaru A, Zweigerdt R, Haverich A, Hilfiker A. Successful re-endothelialization of a perfusable biological vascularized matrix (BioVaM) for the generation of 3D artificial cardiac tissue. Basic Res Cardiol. 2014;109(6):441.
  8. Vukadinovic-Nikolic Z, Andrée B, Dorfman SE, Pflaum M, Horvath T, Lux M, Venturini L, Bär A, Kensah G, Lara AR, Tudorache I, Cebotari S, Hilfiker-Kleiner D, Haverich A, Hilfiker A. Generation of bioartificial heart tissue by combining a three-dimensional gel-based cardiac construct with decellularized small intestinal submucosa. Tissue Eng Part A. 2014 Feb;20(3-4):799-809.
  9. Aper T, Wilhelmi M, Gebhardt C, Hoeffler K, Benecke N, Hilfiker A, Haverich A. Novel method for the generation of tissue-engineered vascular grafts based on a highly compacted fibrin matrix. Acta Biomater. 2016 Jan;29:21-32.
  10. Tudorache I, Calistru A, Baraki H, Meyer T, Höffler K, Sarikouch S, Bara C, Görler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic replacement of aortic heart valves with tissue-engineered grafts. Tissue Eng Part A. 2013 Aug;19(15-16):1686-94.

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