REBIRTH Mitglieder

Gossler, Achim

Gossler, Achim, Prof. Dr. rer. nat.

Professor for Molecular Biology

REBIRTH Unit Notch signalling and ciliogenesis

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

Gossler.Achim(at)mh-hannover.de

Biography / About

Date of Birth:January, 1955
Function:Director

Education:

1983Diplom Biochemstry Eberhard-Karls-University, Tübingen, Germany
1986Dr. rer. nat. Tübingen (Friedrich-Miescher-Laboratory (FML) of the MPG)

Academic appointments and Research posts:

1986 - 1987Postdoctoral Fellow at the FML (Dr. Rolf Kemler)
1987 - 1989Postdoctoral Fellow (Dr. Janet Rossant) at the Mount Sinai Hospital Research Institute, Toronto, Canada [DFG fellowship]
1989 - 1994Head of an independent research group at the Max-Delbrück-Laboratory, Cologne
1994 - 1997Associate Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
1997 - 1999Staff Scientist, The Jackson Laboratory, Bar Harbor, ME
Since 1999Professor for Molecular Biology, Medizinische Hochschule Hannover, Germany

Other professional activities:

2004 - 2012Bennigsen-Foerder-Preis of the Province Nordrhein-Westfalen, Germany

Awards and Prizes:

1991Bennigsen-Foerder-Preis of the Province Nordrhein-Westfalen, Germany

Major research interests:

  • Motile cilia
  • Primary cilia dyskinesis
  • FOXJ1
  • Notch ligand function

Selected Publications:

  1. Stauber M, Weidemann M, Dittrich Breiholz O, Lobschat K, Alten L, Mai M, Beckers A, Kracht M, Gossler A. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Dev Biol. 2016 Nov 30.
  2. Weidemann M, Schuster-Gossler K, Stauber M, Wrede C, Hegermann J, Ott T, Boldt K, Beyer T, Serth K, Kremmer E, Blum M, Ueffing M, Gossler A. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development. 2016 Dec 15;143(24):4736–48.
  3. Schuster-Gossler K, Cordes R, Müller J, Geffers I, Delany-Heiken P, Taft M, Preller M, Gossler A. Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1. Genetics. Genetics; 2016 Mar;202(3):1119–33.
  4. Preusse K, Tveriakhina L, Schuster-Gossler K, Gaspar C, Rosa AI, Henrique D, Gossler A, Stauber M. Context-Dependent Functional Divergence of the Notch Ligands DLL1 and DLL4 In Vivo. Copenhaver GP, editor. PLoS Genet. Public Library of Science; 2015 Jun;11(6):e1005328.
  5. Braune E-B, Schuster-Gossler K, Lyszkiewicz M, Serth K, Preusse K, Madlung J, Macek B, Krueger A, Gossler A. S/T Phosphorylation of DLL1 Is Required for Full Ligand Activity In Vitro but Dispensable for DLL1 Function In Vivo during Embryonic Patterning and Marginal Zone B Cell Development. Mol Cell Biol. 2014 Mar 31;34(7):1221–33.
  6. Alten L, Schuster-Gossler K, Beckers A, Groos S, Ulmer B, Hegermann J, Ochs M, Gossler A. Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1. Development. Oxford University Press for The Company of Biologists Limited; 2012 Apr;139(7):1276–84
  7. Sörensen I, Adams RH, Gossler A. DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries. Blood. American Society of Hematology; 2009 May 28;113(22):5680–8.
  8. Feller J, Schneider A, Schuster-Gossler K, Gossler A. Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation. Genes Dev. 2008 Aug 15;22(16):2166–71.
  9. Schuster-Gossler K, Cordes R, Gossler A. Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci USA. 2007 Jan 9;104(2):537–42.
  10. Beckers A, Alten L, Viebahn C, Andre P, Gossler A. The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning. Proc Natl Acad Sci USA. 2007 Oct 2;104(40):15765–70.


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