REBIRTH Mitglieder

Glage, Silke

Glage, Silke, Dr. med. vet.

Arbeitsgruppenleiter

REBIRTH Unit Histopathology of Animal Models and Teratoma - Veterinary Pathology, Zentrales Tierlaboratorium und Institut für Versuchstierkunde, MHH


Biography / About

Date of Birth:September, 1971
Function:Head of Experimental Pathology, Animal Wellfare Officer (des. Vet.)

Education:

1992 - 1997Study in veterinary medicine, University of Veterinary Medicine, Hannover
01/1998Veterinary Degree
1998 - 2001Thesis in Pathology, “Immunhistochemical diagnosis of intraocular melanomas in cats and dogs”. Department of Pathology, University of Veterinary Medicine, Hannover, Prof. Dr. Dr. W. Drommer.
05/2001Doctoral degree
2002 - 2005Resident in European College for Laboratory Animal Medicine, Prof. Dr. H.-J. Hedrich, Institute for Laboratory Animal Science and Central Animal Facility
11/2005 - 08/2009Veterinarian at the Institute for Laboratory Animal Science and Central Animal Facility. Research: Preclinic study with the International Neuroscience Institute Prof. Dr. Th. Brinker, Prof. Dr. Madjid Samii
2007Examen ECLAM
Since 2009Head of the working group Experimental Pathology at the Institute for Laboratory Animal Science.

Academic appointments and Research posts:

1998 - 1999Preclinic study at the Clinic for otolaryngorhinology, Hannover Medical School (MHH), Prof. Dr. Benno Weber.
2000Scientific assistance, Department of Pathology, University of Veterinary Medicine Hannover, Prof. Dr. Dr. W. Drommer.
2001Veterinarian at Excorp Medical GmbH, Hannover
11/2005 - 08/2009Preclinic study with the International Neuroscience Institute Prof. Dr. Th. Brinker, Prof. Dr. Madjid Samii, in cooperation with CellMed AG, Alzenau.
Since 2009Head of the working group Experimental Pathology at the Institute for Laboratory Animal Science.

Other professional activities:

  • National Representative, Germany, ESLAV
  • Examinations Committee, ECLAM

Major research interests:

  • Inflammatory Bowel Disease
  • Lung infections

Selected Publications:

  1. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus). Schrimpf C, Wrede C, Glage S, Hegermann J, Backhaus S, Blasczyk R, Heuft HG, Müller T. Transfusion. 2017 Jan;57(1):60-69.
  2. Long-Term Culture of Porcine Induced Pluripotent Stem-Like Cells Under Feeder-Free Conditions in the Presence of Histone Deacetylase Inhibitors. Petkov S, Glage S, Nowak-Imialek M, Niemann H. Stem Cells Dev. 2016 Mar 1;25(5):386-94.
  3. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Stem Cell Reports. 2016 Aug 9;7(2):292-305.
  4. Derivation and characterization of bovine induced pluripotent stem cells by transposon-mediated reprogramming. Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Niemann H, Kues WA. Cell Reprogram. 2015 Apr;17(2):131-40. doi: 10.1089/cell.2014.0080.
  5. Non-viral reprogramming of fibroblasts into induced pluripotent stem cells by Sleeping Beauty and piggyBac transposons. Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Kues WA. Biochem Biophys Res Commun. 2014 Jul 18;450(1):581-7.
  6. Primate iPS cells as tools for evolutionary analyses. Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Göhring G, Glage S, Schambach A, Curnow EC, Pääbo S, Martin U, Enard W. Stem Cell Res. 2014 May;12(3):622-9.
  7. Mesenchymal stem cells directly interact with breast cancer cells and promote tumor cell growth in vitro and in vivo. Mandel K, Yang Y, Schambach A, Glage S, Otte A, Hass R. Stem Cells Dev. 2013 Dec 1;22(23):3114-27.
  8. Induction of pluripotent stem cells from a cynomolgus monkey using a polycistronic simian immunodeficiency virus-based vector, differentiation toward functional cardiomyocytes, and generation of stably expressing reporter lines. Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Göhring G, Curnow EC, Martin U. Cell Reprogram. 2012 Dec;14(6):471-84.
  9. An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions.Dutow P, Wask L, Bothe M, Fehlhaber B, Laudeley R, Rheinheimer C, Yang Z, Zhong G, Glage S, Klos A.Pathog Dis. 2016 Mar;74(2)
  10. CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Milanez-Almeida P, Ulas T, Pasztoi M, Glage S, Schughart K, Lutz MB, Schultze JL, Huehn J.Eur J Microbiol Immunol (Bp). 2015 Nov 4;5(4):246-55.


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