REBIRTH Mitglieder

Meyer-Hermann, Michael

Meyer-Hermann, Michael, Prof. Dr. rer. nat.

Leiter

System-Immunologie Helmholtz Zentrum für Infektionsforschung


Biography / About

Date of Birth:July, 1967
Function:Head of Department

Education:

1988 – 1994Studies in Physics, Mathematics, Philosophy, Goethe-University Frankfurt/Main and University Pierre et Marie Curie Paris
1994Diploma in Physics, Goethe-University Frankfurt/Main
1997PhD in Theoretical Physics, Goethe University Frankfurt/Main

Academic appointments and Research posts:

2004Research fellow at the Centre for Mathematical Biology, Mathematical Institute, Oxford University, UK
2005 – 2010Fellow at the Frankfurt Institute for Advanced Studies (FIAS), Johann Wolfgang Goethe-University, Frankfurt/Main, Germany
Since 2010Professor (W3) at the Technical University of Braunschweig, and Head of the Department “Systems Immunology” at the Helmholtz Centre for Infection Research Braunschweig

Other professional activities:

  • Board of directors of “Braunschweig Integrated Centre of Systems Biology” (BRICS)
  • Member of the Society for Mathematical Biology (SMB) and Biophysical Society
  • Reviewer for journals and funding agencies including DFG, Human Frontier Science Program, Medical Research Council, Journal of Experimental Medicine, Journal of Immunology, Nature Immunology, PNAS, Physical Review D and E, Bulletin of Mathematical Biology, Biophysical Journal, BMC Systems Biology

Awards and Prizes:

1994Award of the WE-Heraeus-Foundation
2004EU Marie-Curie Fellowship for a research project with Prof. Dr. P.K. Maini at the Centre for Mathematical Biology, Oxford University, UK
2006ALTANA-Award for fundamental research in Theoretical Immunology

Major research interests:

  • Spatiotemporal modelling of immunological systems
  • Viral and bacterial infections
  • B-, T-, and NK-cell immunity
  • Neuroendocrine-immune-system interactions
  • Optimisation of therapeutic protocols

Furthermore:

Prof. Meyer-Hermann’s research is focused on understanding the dynamics and spatial organisation of biological systems with methods stemming from Mathematics and Statistical Physics. During his scientific career, he developed intense scientific collaboration with local and international experimental groups. The theoretical approach relies on collaborations with experimental partners, subsequently leading to synergistic enrichments of the science on both sides, theory and experiment.

Selected Publications:

  1. Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, et al. In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Immunity [Internet]. 2016 Feb 16 [cited 2017 Mar 30];44(2):233–45. Available from: www.ncbi.nlm.nih.gov/pubmed/26872694
  2. Tas JMJ, Mesin L, Pasqual G, Targ S, Jacobsen JT, Mano YM, et al. Visualizing antibody affinity maturation in germinal centers. Science (80- ) [Internet]. 2016 Mar 4 [cited 2017 Mar 30];351(6277):1048–54. Available from: www.ncbi.nlm.nih.gov/pubmed/26912368
  3. Khailaie S, Robert PA, Toker A, Huehn J, Meyer-Hermann M. A Signal Integration Model of Thymic Selection and Natural Regulatory T Cell Commitment. J Immunol [Internet]. 2014 Dec 15 [cited 2017 Mar 30];193(12):5983–96. Available from: www.ncbi.nlm.nih.gov/pubmed/25392533
  4. Hernandez-Vargas EA, Wilk E, Canini L, Toapanta FR, Binder SC, Uvarovskii A, et al. Effects of Aging on Influenza Virus Infection Dynamics. J Virol [Internet]. 2014 Apr 15 [cited 2017 Mar 30];88(8):4123–31. Available from: www.ncbi.nlm.nih.gov/pubmed/24478442
  5. Zhang Y, Meyer-Hermann M, George LA, Figge MT, Khan M, Goodall M, et al. Germinal center B cells govern their own fate via antibody feedback. J Exp Med [Internet]. 2013 Mar 11 [cited 2017 Mar 30];210(3):457–64. Available from: www.ncbi.nlm.nih.gov/pubmed/23420879
  6. Meyer-Hermann M, Mohr E, Pelletier N, Zhang Y, Victora GD, Toellner K-M. A Theory of Germinal Center B Cell Selection, Division, and Exit. Cell Rep [Internet]. 2012 Jul 26 [cited 2017 Mar 30];2(1):162–74. Available from: www.ncbi.nlm.nih.gov/pubmed/22840406
  7. Victora GD, Schwickert TA, Fooksman DR, Kamphorst AO, Meyer-Hermann M, Dustin ML, et al. Germinal center dynamics revealed by multiphoton microscopy with a photoactivatable fluorescent reporter. Cell [Internet]. NIH Public Access; 2010 Nov 12 [cited 2017 Mar 30];143(4):592–605. Available from: www.ncbi.nlm.nih.gov/pubmed/21074050
  8. Garin A, Meyer-Hermann M, Contie M, Figge MT, Buatois V, Gunzer M, et al. Toll-like Receptor 4 Signaling by Follicular Dendritic Cells Is Pivotal for Germinal Center Onset and Affinity Maturation. Immunity [Internet]. 2010 Jul 23 [cited 2017 Mar 30];33(1):84–95. Available from: www.ncbi.nlm.nih.gov/pubmed/20643339
  9. Meyer-Hermann M, Figge MT, Straub RH. Mathematical modeling of the circadian rhythm of key neuroendocrine-immune system players in rheumatoid arthritis: A systems biology approach. Arthritis Rheum [Internet]. 2009 Sep [cited 2017 Mar 30];60(9):2585–94. Available from: www.ncbi.nlm.nih.gov/pubmed/19714618
  10. Figge MT, Garin A, Gunzer M, Kosco-Vilbois M, Toellner K-M, Meyer-Hermann M. Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med [Internet]. 2008 Dec 22 [cited 2017 Mar 30];205(13):3019–29. Available from: www.ncbi.nlm.nih.gov/pubmed/19047437


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