REBIRTH Mitglieder

Sharma, Amar Deep

Sharma, Amar Deep, PhD

Arbeitsgruppenleiter

REBIRTH Unit miRNA in Liver Regeneration Klinik für Gastroenterologie, Hepatologie und Endokrinologie Medizinische Hochschule Hannover


Biosketch:

A. Sharma (*1979), PhD, is leading the REBIRTH group ‘miRNA in liver regeneration’ in De-partment of Gastroenterology, Hepatology and Endocrinology at MHH. His recent research on the amelioration of liver fibrosis via transcription factors-induced transprogramming of fibrogenic cells into functional hepatocytes, has received two prestigious “Publication of the Year Awards” from the “German Stem Cell Network” and the “German Association for the Study of the Liver”. Based on his ongoing work on transprogramming and non-coding RNA he aims to develop clinically applicable, safe, non-viral, non-integrating RNA-based therapeutics for the treatment of chronic and acute liver failure.

Biography / About

Date of Birth:February, 1979
Function:Group Leader

Education:

07/2000 – 06/2002Master of Science in Biotechnology, Jawaharlal Nehru University, New Delhi, India
10/2002 – 11/2005Ph.D., Stem Cell Biology, MD/PhD Program, Hannover Medical School (MHH), Hannover, Germany

Academic appointments and Research posts:

08/2006 – 04/2009Postdoctoral Research fellow, Institute for Regenerative Medicine, University of California, San Francisco, USA
05/2009 – 10/2012Postdoctoral Research fellow, Department of Gastroenterology, Hepatology and Endocrinology, MHH, Hannover, Germany
Since 11/2012Group Leader, “MicroRNA in Liver Regeneration” in Cluster of Excellence, REBIRTH and Department of Gastroenterology, Hepatology and Endocrinology, MHH, Hannover, Germany

Other professional activities:

Since 11/2011Reviewer for scientific journals: (Hepatology, Journal of Hepatology, Molecular Oncology, Cell Death & Diseases and BMC Cancer)
Since 11/2011Lecturer in regenerative medicine in Hannover Biomedical Research School (HBRS), MHH, Hannover, Germany
Since 11/2012External co-supervisor for PhD students in the HBRS, MHH, Hannover, Germany
02/2013 – 12/2014Reviewer for French National Research Agency and Italian Alessandro Liberati

Awards and Prizes:

11/2011Best poster Prize at 17 Symposium Hochschulinterne Leistungsförderung, MHH, Hannover, Germany
04/2013Award from Gilead Sciences International Research Scholars Program in Liver Diseases, Amsterdam, The Netherlands
06/2016 Travel grant from FASEB Liver Meeting, Florida, USA
09/2016“Publication of the year award” by German Stem Cell Network (Publication: Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis. Cell Stem Cell, 2016)
01/2017German association of study of liver diseases “(GASL)-Prize of YAEL Foundation”

Major research interests:

  • Liver Regeneration
  • Direct Reprogramming
  • MicroRNA
  • Liver Fibrosis
  • Stem Cells

Selected Publications:

  1. Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer BM, Araúzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M*, Sharma AD*. Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis. Cell Stem Cell. 2016 June 2,18(6):797-808. (*Corresponding authors).
  2. Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p mimic inhibits acute liver failure. Nature Communications. 2016 June 23,7:11916.
  3. Möbus S, Yang D, Yuan Q, Lüdtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Vogel A, Manns MP, Ott M, Cantz T*, Sharma AD*. MicroRNA-199a-5p inhibition enhances liver repopulation ability of human embryonic stem cell-derived hepatic cells. Journal of Hepatology. 2015; 62:101-10. (*Corresponding authors).
  4. Yuan Q, Loya K, Rani B, Möbus S, Balakrishnan A, Lamle J, Cathomen T, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-221 overexpression accelerates hepatocyte proliferation during liver regeneration. Hepatology. 2013; 57(1):299-310.
  5. Sharma AD*, Narain N, Handel E-M, Iken M, Singhal N, Cathomen T, Manns MP, Scholer HR, Ott M, Cantz T. MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology. 2011; 53:1651-61. (*Corresponding author).
  6. Song G#, Sharma AD#, Roll GR, Blelloch RH, Willenbring H. MicroRNAs Control Hepatocyte Proliferation During Liver Regeneration. Hepatology. 2010; 51:1735-1743. (#Both authors share first authorship).
  7. Sharma AD#, Cantz T#, Vogel A, Schambach A, Hairdass D, Iken M, Bleidißel M, Manns MP, Schöler HR, Ott M. Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation. Cell Transplantation. 2008;17:313-323. (#Both authors share first authorship).
  8. Willenbring H, Sharma AD, Vogel A, Lee AY, Rothfuss A, Wang Z, Finegold M, Grompe M. Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis. Cancer Cell. 2008;14:59-67.
  9. Sharma AD, Cantz T, Richter R, Eckert K, Henschler R, Wilkens L, Jochheim-Richter A, Arseniev L, Ott M. Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am J Pathol. 2005;167:555-64.
  10. Cantz T#, Sharma AD#, Jochheim-Richter A, Arseniev L, Klein C, Manns MP, Ott M. Reevaluation of bone-marrow derived cells as a source for hepatocyte regeneration. Cell Transplantation. 2004;13:659-66. (#Both authors share first authorship).


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