REBIRTH Mitglieder

Sewald, Katharina

Sewald, Katharina, Dr. rer. nat.


REBIRTH Unit Preclinical Safety and Toxicology

Fraunhofer Institut für Toxikologie und Experimentelle Medizin (ITEM)
Nicolai-Fuchs-Str. 1
30625 Hannover


Biography / About

Date of Birth:November, 1974
Function:Head of Department Preclinical Pharmacology and Immunology Preclinical Pharmacology and In-Vitro Toxicology


1993Higher secondary education (German A-levels), Petri-Gymnasium, Leipzig
1993 - 1998Study of Biochemistry, University of Leipzig
1998 - 2001Dissertation, University of Leipzig (Institute for Organic Chemistry)
2001 - 2005Postdoctoral Research Fellow, University of Leipzig and University of Bielefeld
2002 - 2005Study of Human Medicine, University of Bochum

Academic appointments and Research posts:

Since 2005Head of Department Preclinical Pharmacology and Immunology, Fraunhofer ITEM, Hannover
Since 2013Principal Investigator, DZL BREATH, Hannover

Other professional activities:

Since 2005Additional qualifications: project management, GLP qualifications
Since 2005Reviewer for the following journals: Toxicology in vitro, Toxicology and Applied Pharmacology, American Journal of Respiratory Cell and Molecular Biology/AJRCMB, Nanotoxicology, international grants
Since 2012Steering Group for the Respiratory Toxicity Workshop

Awards and Prizes:

2009Young Scientist Award, Eurotox

Major research interests:

  • Tissue culture technology
  • Alternative methods in in vitro toxicology
  • Mechanisms of inflammation, injury
  • Pathophysiology of asthma
  • Pharmaceutical development

Selected Publications:

  1. L. Lauenstein, S. Switalla, F. Prenzler, S. Seehase, O. Pfennig, C. Förster, H. Fieguth, A. Braun, K. Sewald Toxicology in vitro 2014, Assessment of immunotoxicity induced by chemicals in human precision-cut lung slices (PCLS), accepted for publication,.
  2. Neuhaus V, Chichester JA, Ebensen T, Schwarz K, Hartman CE, Shoji Y, Guzmán CA, Yusibov V, Sewald K, Braun A. Vaccine. 2014 A new adjuvanted nanoparticle-based H1N1 influenza vaccine induced antigen-specific local mucosal and systemic immune responses after administration into the lung.
  3. Neuhaus V, Schwarz K, Klee A, Seehase S, Förster C, Pfennig O, Jonigk D, Fieguth HG, Koch W, Warnecke G, Yusibov V, Sewald K, Braun A., PLOS ONE 2013, Functional testing of an inhalable nanoparticle based influenza vaccine using a human precision cut lung slice technique.
  4. S. Seehase, H. D. Lauenstein, C. Schlumbohm, S. Switalla, V. Neuhaus, C. Förster, E. Fuchs, F. J. Kaup, M. Zöller, A. Braun, K. Sewald*, S. Knauf*, PLoS ONE 2012, accepted. LPS-induced lung inflammation in marmoset monkeys – an acute model for anti-inflammatory drug testing. *contributed equally
  5. K. Sewald & A. Braun, Progress Towards Novel Testing Strategies for in vitro Assessment of Allergens 2011, Editor(s) E. L. Roggen, H.-U. Weltzien, H. Hermans, PCLS: From learning about ‘in vivo’ to reduction and replacement
  6. S. Switalla, J. Knebel, D. Ritter, N. Krug, A. Braun, K. Sewald*, Toxicol. Lett. 2010, 196, 117-124. Effects of acute in vitro exposure of murine precision-cut lung slices to gaseous nitrogen dioxide and ozone in an air-liquid interface (ALI) culture.
  7. S. Seehase, M. Schlepütz, S. Switalla, K. Mätz-Rensing, F. J. Kaup, M. Zöller, C. Schlumbohm, E. Fuchs, H. D. Lauenstein, C. Winkler, A. R. Kuehl, S. Uhlig, A. Braun, K. Sewald,* C. Martin,* J. Appl. Physiol. 2011, 111, 791-798. Bronchoconstriction in nonhuman primates: a species comparison. *contributed equally.
  8. S. Switalla, L. Lauenstein, F. Prenzler, S. Knothe, C. Förster, H. G. Fieguth, O. Pfennig, F. Schaummann, C. Martin, C. A. Guzman, T. Ebensen, M. Müller, J. M. Hohlfeld, N. Krug, A. Braun, K. Sewald*, Toxicol. Appl. Pharmacol. 2010, 246, 107-115. Natural innate cytokine response to immunomodulators and adjuvants in human precision-cut lung slices.
  9. M. Henjakovic*, K. Sewald*, S. Switalla, D. Kaiser, M. Müller, T. Z. Veres, M. Martin, S. Uhlig, N. Krug, A. Braun, TAAP 2008, 231, 68-76. Ex vivo testing of immune responses in precision cut lung slices. contributed equally,
  10. Anikin, A. Buchynskyy, U. Kempin, K. Stembera, P. Welzel, G. Lantzsch, Angew. Chem. 1999, 111, 3931; Angew. Chem. Int. Ed. 1999, 38, 3703. Membrane anchoring and intervesicle transfer of a derivative of the antibiotic moenomycin A.

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