REBIRTH Mitglieder

Falk, Christine Susanne

Falk, Christine Susanne , Prof. Dr. rer. nat.

Institute director

Transplant Immunology, IFB-Tx


Biography / About

Date of Birth:November, 1966
Function:Institute director, full (W3) Professor

Education:

10/1985 – 01/1990Studies in Biology, LMU Munich, Germany
02/1990 – 10/1991Diploma thesis, degree Biology Diploma, LMU Munich
10/1991 – 10/1996 PhD thesis, Institute of Immunology, LMU Munich

Academic appointments and Research posts:

11/1991 – 10/1996PhD student at Institute for Immunology at LMU Munich (Director Prof. Dr. G. Riethmüller, supervisor Prof. Dr. D.J. Schendel)
11/1996 – 12/1998Postdoc at Institute for Immunology, LMU Munich (Director Prof. Dr. G. Riethmüller, supervisor Prof. Dr. D.J. Schendel)
01/1999 – 04/2006Postdoc, since 2001, group leader at Institute for Molecular Immunology at GSF Munich (Helmholtz Center for Environment and Health, HMGU, Prof. Dr. D.J. Schendel)
05/2006 – 10/2010Head of independent „Immune Monitoring“ group at National Center for Tumor Diseases NCT (Directors Prof. Dr. C. von Kalle, Prof. Dr. D. Jäger), German Cancer Research Center DKFZ (Director Prof. O.D. Wiestler), Institute for Immunology, University Hospital (Prof. Dr. S. Meuer)
Since 11/2010W3-Professorship, head of the Institute of Transplant Immunology, IFB-Tx (Integrated Research and Treatment Center Transplantation) at MHH

Other professional activities:

Since 2003Degree „certified immunologist“(Fachimmunologe) of the German Society for Immunology, DGfI
Since 2010Member of the organization committee of the DGfI Spring School on Immunology
Since 2014Member of the committee for “clinical research” of the Deutsche Krebshilfe e.V., borad member of the DGfI, jury of the Erwin-Schrödinger-Science Award (Deutscher Stifterverband & HGF)
Since 2016Editorial board American Journal of Transplantation and European Journal of Immunology

Awards and Prizes:

1997Walter-Schulz-Award for Tumor Research

Major research interests:

  • Transplant immunology
  • Tumor immunology
  • Sterile inflammation
  • Natural Killer cells
  • T cell responses
  • Cytokines
 
  • Chemokines
  • Microenvironment
  • Immunosuppression
  • Multi kinase inhibitors
  • Angiogenesis
 

Furthermore:

Referee for international journals like J. Immunol, Front. Immunol, Blood, Transplant Immunol., and for research associations like DFG, FNRS, Sander Froundation.

Selected Publications:

  1. Halama, N., Inka Zoernig, I., Spille, A., Christoph Kahlert, C., Klupp, F., Suetterlin, T., Brand, K., Krauss, J., Lasitschka, F., Lerchl, T., Luckner-Minden, C., Ulrich, A., Koch, M., Weitz, J., Schneider, M., Buechler, MW., Zitvogel, L., Herrmann, T., Benner, A., Kunz, C., Luecke, S., Springfeld, C., Grabe, N., Falk, C.S.*, Jaeger, D*. Tumoral immune cell exploitation in colorectal cancer liver metastases can be targeted effectively by anti-CCR5 therapy in cancer patients. *shared senior authors. Cancer Cell 2016. 11;29(4):587-601. doi: 10.1016/j.ccell.2016.03.005.
  2. Siemeni, T., Knöfel, A.K., Madrahimov, N., Sommer, W., Avsar, M., Salman, J., Ius,F., Frank, N., Büchler, G., Dreckmann, K., Danny Jonigk, D., Jansson, K., Maus, U., Falk, C.S., Haverich A. Warnecke G. In vivo development of transplant arteriosclerosis in humanized mice reflects alloantigen recognition and peripheral Treg phenotype of lung transplant recipients. Am J Transplant. 2016 Jun 7. doi: 10.1111/ajt.13905.
  3. Gupta, S.K, Itagaki, R., Zheng, X., Batkai, S., Thum, S., Ahmed, F., van Aelst, L.N., Sharma, A., Piccoli, M.T., Weinberger, F., Fiedler, J., Heuser, M., Heymans, S., Falk, C.S., Förster, R., Schrepfer, S., Thum, T. MiR-21 promotes fibrosis in an acute cardiac allograft transplantation model. Cardiovasc. Res. 2016 Feb 9. pii: cvw030. 2016.
  4. Avsar, M., Jansson, K., Sommer, W., Kruse, B., Thissen, S., Dreckmann, K., Knoefel, A-K., Salman, J., Gottlieb, J., Hafer, C., Hecker, J., Buechler, G., Karstens, J.H., Jonigk, D., Länger, F., Kaever, V., Falk, C.S., Hewicker-Trautwein, M., Ungefroren, H., Haverich, A., Strüber, M., Warnecke, G. Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine. Am J Transplant. 2015 doi: 10.1111/ajt.13629.
  5. Breunig, C., Müller, B.J., Umansky, L., Wahl, K., Hoffmann, K., Lehner, F., Manns, M.P., Bantel, H., Falk, CS. B-Raf and MEK inhibitors differentially regulate cell fate and microenvironment in human hepatocellular carcinoma. Clin. Canc. Res. 2014. 1;20(9):2410-23. doi: 10.1158/1078-0432.CCR-13-1635. Epub 2014.
  6. Hoffmann, U., Neudörfl, C., Daemen, K., Keil, J., Stevanovic-Meyer, J., Lehner, F., Haller, H., Blume, C., Falk, C.S. NK cells of kidney transplant recipients display an activated phenotype that is influenced by immunosuppression and pathological staging. PLOS One. 2015. 6;10(7):e0132484. doi: 10.1371/journal.pone.0132484.
  7. Bernardo-Faura, M., Massen, S., Falk, C.S, Brady, N. R., Eils, R. Data-derived modeling characterizes plasticity of MAPK signaling in melanoma. PLOS Comput. Biology. 2014. 10(9):e1003795. doi: 10.1371/journal.pcbi.1003795.
  8. Neudoerfl, C., Mueller, B., Blume, C., Daemen, K., Stevanovic-Meyer, M., Keil, J., Lehner, F., Haller, H., Falk, CS. The peripheral NK cell repertoire after kidney transplantation is modulated under immunosuppression. Frontiers in Immunol. 2013. 4:46.
  9. Galla, M., Schambach, A., Falk, C.S., Maetzig, T., Kuehle, J., Lange, K., Zychlinski, D., Heinz, N., Brugman, M., Göhring, G., Izsvák, Z., Ivics, Z., Baum C. Avoiding cytotoxicity of transposases by dose-controlled mRNA delivery. Nucleic Acids Res.; 1;39(16):7147-60, 2011.
  10. Halama, N., Braun, M., Kahlert, C., Spille, A., Quack, C., Rahbari, N., Koch, M., Weitz, J., Kloor, M., Zoernig, I., Schirmacher, P., Brand, K., Grabe, N.,Falk, CS. 2011. Natural killer cells are scarce in colorectal carcinoma tissue despite high levels of chemokines & cytokines. Clin. Cancer Res., 2011. 17(4):678-89.


[zurück zur Liste]
test
Diese Webseite verwendet Cookies und die Webanalyse-Software Google Analytics. Klicken Sie hier für weitere Informationen zum Datenschutz.
Einverstanden