Most important publications of the cluster

[1] R. Zweigerdt, R. Olmer, H. Singh, A. Haverich, U. Martin: Scalable expansion of human pluripotent stem cells in suspension culture. Nat Protoc (2011)

[2] G. Wu, N. Liu, I. Rittelmeyer, A.D. Sharma, M. Sgodda, H. Zaehres, M. Bleidissel, B. Greber, L. Gentile, D.W. Han, C. Rudolph, D. Steinemann, A. Schambach, M. Ott, H.R. Scholer, T. Cantz: Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PloS Biol (2011)

[3] A. Puklowski, Y. Homsi, D. Keller, M. May, S. Chauhan, U. Kossatz, V. Grunwald, S. Kubicka, A. Pich, M.P. Manns, I. Hoffmann, P. Gonczy, N.P. Malek: The SCF-FBXW5 E3-ubiquitinligase is regulated by PLK4 and targtes HsSAS-6 to control centrosome duplication. PloS Biol (2011)

[4] T. Kempf, A. Zarbock, C. Widera, S. Butz, A. Stadtmann, J. Rossaint, M. Bolomini-Vittori, M. Korf-Klingebiel, L.C. Napp, B. Hansen, A. Kanwischer, U. Bavendiek, G. Beutel, M. Hapke, M.G. Sauer, C. Laudanna, N. Hogg, D. Vestweber, K.C. Wollert: GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med (2011)

[5] M. Hoch, P. Fischer, B. Stapel, E. Missol-Kolka, B. Sekkali, M. Scherr, F. Favret, T. Braun, M. Eder, K. Schuster-Gossler, A. Gossler, A. Hilfiker, J.L. Balligand, H. Drexler, D. Hilfiker-Kleiner: Erythropoietin Preserves the Endothelial Differentiation Capacity of Cardiac Progenitor Cells and Reduces Heart Failure during Anticancer Therapies. Cell Stem Cell (2011)

[6] D. Heckl, D.C. Wicke, M.H. Brugman, J. Meyer, A. Schambach, G. Busche, M. Ballmaier, C. Baum, U. Modlich: Lentiviral gene transfer regenerates hematopoietic stem cells in a murine model for Mpl-deficient aplastic anemia. Blood (2011)

[7] J. Hauschild, B. Petersen, Y. Santiago, A.L. Queisser, J.W. Carnwath, A. Lucas-Hahn, L. Zhang, X. Meng, P.D. Gregory, R. Schwinzer, G.J. Cost, H. Niemann: Efficient generation of a biallelic knockout in pigs using zinc-finger  nucleases. Proc Natl Acad Sci USA (2011)

[8] S. Cebotari, I. Tudorache, A. Ciubotaru, D. Boethig, S. Sarikouch, A. Goerler, A. Lichtenberg, E. Cheptanaru, S. Barnaciuc, A. Cazacu, O. Maliga, O. Repin, L. Maniuc, T. Breymann, A. Haverich: Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults. Circulation (2011)

[9] A. Braun, T. Worbs, G.L. Moschovakis, S. Halle, K. Hoffmann, J. Boelter, A. Muenk, R. Forster: Afferent lymph–derived T cells and DCs use different chemokine receptor CCR7–dependent routes for entry into the lymph node and intranodal migration. Nat Immunol (2011)

[10] C. Voelkel, M. Galla, T. Maetzig, E. Warlich, J. Kuehle, D. Zychlinski, J. Bode, T. Cantz, A. Schambach, C. Baum: Protein transduction from retroviral Gag precursors. Proc Natl Acad Sci USA (2010)

[11] N. Singhal, J. Graumann, G. Wu, M.J. Arauzo-Bravo, D.W. Han, B. Greber, L. Gentile, M. Mann, H.R. Scholer:Chromatin-Remodeling Components of the BAF Complex facilitate Reprogramming. Cell (2010)

[12] A. Krueger, S. Willenzon, M. Lyszkiewicz, E. Kremmer, R. Forster: CC-chemokine receptor 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus. Blood (2010)

[13] J. Heineke, M. Auger-Messier, R.N. Correll, J. Xu, M.J. Benard, W. Yuan, H. Drexler, L.V. Parise, J.D. Molkentin: CIB1 is a Regulator of Pathological Cardiac Hypertrophy. Nat Med (2010)

[14] D.W. Han, N. Tapia, J.Y. Joo, B. Greber, M.J. Arauzo-Bravo, C. Bernemann, K. Ko, G. Wu, M. Stehling, J.T. Do, H.R. Scholer: Epiblast Stem Cell Subpopulations Represent Mouse Embryos of Distinct Pregastrulation Stages. Cell (2010)

[15] K. Boztug, M. Schmidt, A. Schwarzer, P.P. Banerjee, I.A. Diez, R.A. Dewey, M. Bohm, A. Nowrouzi, C.R. Ball, H. Glimm, S. Naundorf, K. Kuhlcke, R. Blasczyk, I. Kondratenko, L. Marodi, J.S. Orange, C. von Kalle, C. Klein: Stem-Cell Gene Therapy for the Wiskott-Aldrich Syndrome. N Engl J Med (2010)

[16] J. Skokowa, D. Lan, B.K. Thakur, F. Wang, K. Gupta, G. Cario, A.M. Brechlin, A. Schambach, L. Hinrichsen, G. Meyer, M. Gaestel, M. Stanulla, Q. Tong, K. Welte: NAMPT is essential for the G-CSF-induced myeloid differentiation. Nat Med (2009)

[17] J.B. Kim, B. Greber, M.J. Arauzo-Bravo, J. Meyer, K.I. Park, H. Zaehres, H.R. Scholer: Direct reprogramming of human neural stem cells by OCT4. Nature (2009)

[18] A. Haase, R. Olmer, K. Schwanke, S. Wunderlich, S. Merkert, C. Hess, R. Zweigerdt, I. Gruh, J. Meyer, S. Wagner, L.S. Maier, D.W. Han, S. Glage, K. Miller, P. Fischer, H.R. Scholer, U. Martin: Generation of induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell (2009)

[19] M. Farsari, B.N. Chichkov: Two-photon fabrication. Nat Photonics (2009)

[20] V.M. Christoffels, T. Grieskamp, J. Norden, M.T. Mommersteeg, C. Rudat, A. Kispert: Tbx18 and the fate of epicardial progenitors. Nature (2009)

[21] K. Boztug, G. Appaswamy, A. Ashikov, A.A. Schaffer, U. Salzer, J. Diestelhorst, M. Germeshausen, G. Brandes, J. Lee-Gossler, F. Noyan, A.K. Gatzke, M. Minkov, J. Greil, C. Kratz, T. Petropoulou, I. Pellier, C. Bellanne-Chantelot, N. Rezaei, K. Monkemoller, N. Irani-Hakimeh, H. Bakker, R. Gerardy-Schahn, C. Zeidler, B. Grimbacher, K. Welte, C. Klein: A Syndrome with Congenital Neutropenia and Mutations in G6PC3. N Engl J Med (2009)

[22] A. Ovsianikov, J. Viertl, B. Chichkov, M. Oubaha, B. MacCraith, I. Sakellari, A. Giakoumaki, D. Gray, M. Vamvakaki, M. Farsari, C. Fotakis: Ultra-Low Shrinkage Hybrid Photosensitive Material for Two-Photon Polymerization MIcrofabrication. ACS Nano (2008)

[23] C. Mauritz, K. Schwanke, M. Reppel, S. Neef, K. Katsirntaki, L.S. Maier, F. Nguemo, S. Menke, M. Haustein, J. Hescheler, G. Hasenfuss, U. Martin: Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation (2008)

[24] S. Schaetzlein, N.R. Kodandaramireddy, Z. Ju, A. Lechel, A. Stepczynska, D.R. Lilli, A.B. Clark, C. Rudolph, F. Kuhnel, K. Wei, B. Schlegelberger, P. Schirmacher, T.A. Kunkel, R.A. Greenberg, W. Edelmann, K.L. Rudolph: Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional. Cell (2007)

[25] A.R. Choudhury, Z. Ju, M.W. Djojosubroto, A. Schienke, A. Lechel, S. Schaetzlein, H. Jiang, A. Stepczynska, C. Wang, J. Buer, H.W. Lee, T. von Zglinicki, A. Ganser, P. Schirmacher, H. Nakauchi, K.L. Rudolph: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet. (2007)

Most important publications Area A

[1] E. Warlich, J. Kuehle, T. Cantz, M.H. Brugman, T. Maetzig, M. Galla, A.A. Filipczyk, S. Halle, H. Klump, H.R. Scholer, C. Baum, T. Schroeder, A. Schambach: Lentiviral vector design and imagin approaches to visualize the early stages of cellular reprogramming. Mol Ther (2011)

[2] E. Surdziel, M. Cabanski, I. Dallmann, M. Lyszkiewicz, A. Krueger, A. Ganser, M. Scherr, M. Eder: Enforced expression of miR-125b affects myelopoiesis by targeting multiple signaling pathways. Blood (2011)

[3] A. Puklowski, Y. Homsi, D. Keller, M. May, S. Chauhan, U. Kossatz, V. Grunwald, S. Kubicka, A. Pich, M.P. Manns, I. Hoffmann, P. Gonczy, N.P. Malek: The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol (2011)

[4] N. Pfaff, N. Lachmann, S. Kohlscheen, M. Sgodda, M.J. Arauzo-Bravo, B. Greber, W.A. Kues, S. Glage, C. Baum, H. Niemann, A. Schambach, T. Cantz, T. Moritz: Efficient hematopoietic redifferentation of induced pluripotent stem cells derived from primitive murine bone marrow cells. Stem Cells Dev (2011)

[5] N. Pfaff, J. Fiedler, A. Holzmann, T. Moritz, T. Cantz, T. Thum: MiRNA screening reveals a new miRNA family stimulating iPS cell generation via regulation of Meox2. EMBO Rep (2011)

[6] M. Hoch, P. Fischer, B. Stapel, E. Missol-Kolka, B. Sekkali, M. Scherr, F. Favret, T. Braun, M. Eder, K. Schuster-Gossler, A. Gossler, A. Hilfiker, J.L. Balligand, H. Drexler, D. Hilfiker-Kleiner: Erythropoietin Preserves the Endothelial Differentiation Capacity of Cardiac Progenitor Cells and Reduces Heart Failure during Anticancer Therapies. Cell Stem Cell (2011) 

[7] D.W. Han, B. Greber, G. Wu, N. Tapia, M.J. Arauzo-Bravo, K. Ko, C. Bernemann, M. Stehling, H.R. Scholer: Direct reprogramming of fibroblasts into epiblast stem cells. Nat Cell Biol (2011)

[8] A. Haghikia, E. Missol-Kolka, D. Tsikas, L. Venturini, S. Brundiers, M. Castoldi, M.U. Muckenthaler, M. Eder, B. Stapel, T. Thum, E. Petrasch-Parwez, H. Drexler, D. Hilfiker-Kleiner, M. Scherr: Signal transducer and activator of transcription 3-mediated regulation of miR-199a-5b links cardiomyocyte and endothelial cell function in the heart: a key role for ubiquitin-conjugating enzymes. Eur Heart J (2011)

[9] T. Grieskamp, C. Rudat, T.H. Ludtke, J. Norden, A. Kispert: Notch Signaling Regulates Smooth Muscle Differentiation of epicardium-derived cells. Circ Res (2011)

[10] N. Singhal, J. Graumann, G. Wu, M.J. Arauzo-Bravo, D.W. Han, B. Greber, L. Gentile, M. Mann, H.R. Scholer: Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming. Cell (2010)

[11] M.K. Sethi, F.F. Buettner, V.B. Krylov, H. Takeuchi, N.E. Nifantiev, R.S. Haltiwanger, R. Gerardy-Schahn, H. Bakker: Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated. J Biol Chem (2010)

[12] D.W. Han, N. Tapia, J.Y. Joo, B. Greber, M.J. Arauzo-Bravo, C. Bernemann, K. Ko, G. Wu, M. Stehling, J.T. Do, H.R. Scholer: Epiblast stem cell subpopulations represent mouse embryos of distinct pregastrulation stages. Cell (2010)

[13] C. Wiese, T. Grieskamp, R. Airik, M.T. Mommersteeg, A. Gardiwal, C. de Gier-de Vries, K. Schuster-Gossler, A.F. Moorman, A. Kispert, V.M. Christoffels: Formation of the sinus node head and differentiation of sinus node myocardium are independently regulated by tbx18 and Tbx3. Circ Res (2009)

[14] R. Singh, T. Horsthuis, H.F. Farin, T. Grieskamp, J. Norden, M. Petry, V. Wakker, A.F. Moorman, V.M. Christoffels, A. Kispert: Tbx20 interacts with smads to confine tbx2 expression to the atrioventricular canal. Circ Res (2009)

[15] T.H. Ludtke, V.M. Christoffels, M. Petry, A. Kispert: Tbx3 promotes liver bud expansion during mouse development b suppression of cholangiocyte differentiation. Hepatology (2009)

[16] K. Ko, N. Tapia, G. Wu, J.B. Kim, M.J. Bravo, P. Sasse, T. Glaser, D. Ruau, D.W. Han, B. Greber, K. Hausdorfer, V. Sebastiano, M. Stehling, B.K. Fleischmann, O. Brustle, M. Zenke, H.R. Scholer: Induction of pluripotency in adult unipotent germline stem cells. Cell Stem Cell (2009)

[17] J.B. Kim, B. Greber, M.J. Arauzo-Bravo, J. Meyer, K.I. Park, H. Zaehres, H.R. Scholer: Direct reprogramming of human neutral stem cells by OCT4. Nature (2009)

[18] S. Halle, H.C. Dujardin, N. Bakocevic, H. Fleige, H. Danzer, S. Willenzon, Y. Suezer, G. Hammerling, N. Garbi, G. Sutter, T. Worbs, R. Forster: Induced bronchus-associated lymphoid tissue serves as a general priming site for T cells and is maintained by dendric cells. J Exp Med (2009)

[19] A. Haase, R. Olmer, K. Schwanke, S. Wunderlich, S. Merkert, C. Hess, R. Zweigerdt, I. Gruh, J. Meyer, S. Wagner, L.S. Maier, D.W. Han, S. Glage, K. Miller, P. Fischer, H.R. Scholer, U. Martin: Generation of induced pluripotent stem cells from human cord blood. Cell Stem Cell (2009)

[20] V.M. Christoffels, T. Grieskamp, J. Norden, M.T. Mommersteeg, C. Rudat, A. Kispert: Tbx18 and the fate of epicardial progenitors. Nature (2009)

[21] C. Mauritz, K. Schwanke, M. Reppel, S. Neef, K. Katsirntaki, L.S. Maier, F. Nguemo, S. Menke, M. Haustein, J. Hescheler, G. Hasenfuss, U. Martin: Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation (2008)

[22] J.B. Kim, H. Zaehres, G. Wu, L. Gentile, K. Ko, V. Sebastiano, M.J. Arauzo-Bravo, D. Ruau, D.W. Han, M. Zenke, H.R. Scholer: Pluripotent stem cells induced from adult neutral stem cells by reprogrammiring with two factors. Nature (2008)

[23] R. Forster, A.C. Davalos-Misslitz, A. Rot: CCR7 and its ligands balancing immunity and tolerance. Nat
Rev Immunol (2008)

[24] J. Feller, A. Schneider, K. Schuster-Gossler, A. Gossler: Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization an boundary formation. Genes Dev (2008)

[25] K. Schuster-Gossler, R. Cordes, A. Gossler: Premature myogenic differentiation and depletion of progenitor cells cause severe muscle hypotrophy in Delta1 mutants. Proc Natl Acad Sci USA (2007)

[26] S. Schaetzlein, N.R. Kodandaramireddy, Z. Ju, A. Lechel, A. Stepczynska, D.R. Lilli, A.B. Clark, C. Rudolph, F. Kuhnel, K. Wei, B. Schlegelberger, P. Schirmacher, T.A. Kunkel, R.A. Greenberg, W. Edelmann, K.L. Rudolph: Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice. Cell (2007)

[27] A. Limbourg, M. Ploom, D. Elligsen, I. Sorensen, T. Ziegelhoeffer, A. Gossler, H. Drexler, F.P. Limbourg: Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res (2007)

[28] Z. Ju, H. Jiang, M. Jaworski, C. Rathinam, A. Gompf, C. Klein, A. Trumpp, K.L. Rudolph: Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med (2007)

[29] A.R. Choudhury, Z. Ju, M.W. Djojosubroto, A. Schienke, A. Lechel, S. Schaetzlein, H. Jiang, A. Stepczynska, C. Wang, J. Buer, H.W. Lee, T. von Zglinicki, A. Ganser, P. Schirmacher, H. Nakauchi, K.L. Rudolph: Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet (2007)

[30] A. Beckers, L. Alten, C. Viebahn, P. Andre, A. Gossler: The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning. Proc Natl Acad Sci USA (2007)

Most important publications Area B (Biomedicine)

[1] G. Wu, N. Liu, I. Rittelmeyer, A.D. Sharma, M. Sgodda, H. Zaehres, M. Bleidissel, B. Greber, L. Gentile, D.W. Han, C. Rudolph, D. Steinemann, A. Schambach, M. Ott, H.R. Scholer, T. Cantz: Generation of Healthy Mice from Gene-Corrected Disease-specific Induced Pluripotent Stem Cells. PloS Biol (2011)

[2] T. Thum, N. Chau, B. Bhat, S.K. Gupta, P.S. Linsley, J. Bauersachs, S. Engelhardt: Comparison of different miR-21 inhibitor chemistries in a cardiac disease model. J Clin Invest (2011)

[3] A.D. Sharma, N. Narain, E.M. Handel, M. Iken, N. Singhal, T. Cathomen, M.P. Manns, H.R. Scholer, M. Ott, T. Cantz: MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology (2011)

[4] C. Mauritz, A. Martens, S.V. Rojas, T. Schnick, C. Rathert, N. Schecker, S. Menke, S. Glage, R. Zweigerdt, A. Haverich, U. Martin, I. Kutschka: Induced pluripotent stem cell (iPSC)-derived Flk-1progenitor cells engraft, differentiate, and improve heart function in a mouse model of acute myocardial infarction. Eur Heart J (2011)

[5] T. Maetzig, M.H. Brugman, S. Bartels, N. Heinz, O.S. Kustikova, U. Modlich, Z. Li, M. Galla, B. Schiedlmeier, A. Schambach, C. Baum: Polyclonal fluctuation of lentiviral vector-transduced and expanded murine hematopoietic stem cells. Blood (2011)

[6] M. Korf-Klingebiel, T. Kempf, K.D. Schluter, C. Willenbockel, T. Brod, J. Heineke, V.J. Schmidt, F. Jantzen, R.P. Brandes, P.H. Sugden, H. Drexler, J.D. Molkentin, K.C. Wollert: Conditional transgenic expression of fibroblast growth factor 9 in the adult mouse heart reduces heart failure mortality after myocardial infarction. Circulation (2011)

[7] T. Kempf, A. Zarbock, C. Widera, S. Butz, A. Stadtmann, J. Rossaint, M. Bolomini-Vittori, M. Korf-Klingebiel, L.C. Napp, B. Hansen, A. Kanwischer, U. Bavendiek, G. Beutel, M. Hapke, M.G. Sauer, C. Laudanna, N. Hogg, D. Vestweber, K.C. Wollert: GDF-15 is an inhibitor of leukocyte integrin activation required for survival after myocardial infarction in mice. Nat Med (2011)

[8] D. Heckl, D.C. Wicke, M.H. Brugman, J. Meyer, A. Schambach, G. Busche, M. Ballmaier, C. Baum, U. Modlich: Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpi-deficient aplastic anemia. Blood (2011)

[9] D. Fraccarollo, S. Berger, P. Galuppo, S. Kneitz, L. Hein, G. Schutz, S. Frantz, G. Ertl, J. Bauersachs: Deletion of cardiomyocyte mineralocorticoid receptor ameliorates adverse remodeling after myocardial infarction. Circulation (2011)

[10] J. Fiedler, V. Jazbutyte, B.C. Kirchmaier, S.K. Gupta, J. Lorenzen, D. Hartmann, P. Galuppo, S. Kneitz,J.T. Pena, C. Sohn-Lee, X. Loyer, J. Soutschek, T. Brand, T. Tuschl, J. Heineke, U. Martin, S. Schulte-Merker, G. Ertl, S. Engelhardt, J. Bauersachs, T. Thum: MicroRNA-24 Regulates Vascularity After Myocardial Infarction. Circulation (2011)

[11] A. Braun, T. Worbs, G.L. Moschovakis, S. Halle, K. Hoffmann, J. Boelter, A. Muenk, R. Forster: Afferent lymph-derived T cells and dendritic cells and dendritic cells use different CCR7-dependent routes for lymph node entry and intranodal migration. Nat Immunol (2011)

[12] G. Song, A.D. Sharma, G.R. Roll, R. Ng, A.Y. Lee, R.H. Blelloch, N.M. Frandsen, H. Willenbring: MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology (2010)

[13] U. Kossatz, K. Breuhahn, B. Wolf, M. Hardtke-Wolenski, L. Wilkens, D. Steinemann, S. Singer, F. Brass, S. Kubicka, B. Schlegelberger, P. Schirmacher, M.P. Manns, J.D. Singer, N.P. Malek: The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells. J Clin Invest (2010)

[14] J. Heineke, M. Auger-Messier, R.N. Correll, J. Xu, M.J. Benard, W. Yuan, H. Drexler, L.V. Parise, J.D. Molkentin: CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med (2010)

[15] F. Fleissner, V. Jazbutyte, J. Fiedler, S.K. Gupta, X. Yin, Q. Xu, P. Galuppo, S. Kneitz, M. Mayr, G. Ertl, J. Bauersachs, T. Thum: Short communication_asymmetric dimethylarginine impairs angiogenic progenitor cell function. Circ Res (2010)

[16] A. Bar, S.E. Dorfman, P. Fischer, D. Hilfiker-Kleiner, S. Cebotari, I. Tudorache, M. Suprunov, A. Haverich, A. Hilfiker: The pro-angiogenic factor CCN1 enhances the re-endothelialization of biological vascularized matrices in vitro. Cardiovasc Res (2010)

[17] J. Skokowa, D. Lan, B.K. Thakur, F. Wang, K. Gupta, G. Cario, A.M. Brechlin, A. Schambach, L. Hinrichsen, G. Meyer, M. Gaestel, M. Stanulla, Q. Tong, K. Welte: NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD+-sirtuin-1-dependent pathway. Nat Med (2009)

[18] A. Limbourg, T. Korff, L.C. Napp, W. Schaper, H. Drexler, F.P. Limbourg: Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat Protoc (2009)

[19] J. Huehn, J.K. Polansky, A. Hamann: Epigenetic control of FOXP3 expression_the key to a stable regulatory T-cell lineage? Nat Rev Immunol (2009)

[20] C. Figueiredo, M. Wittmann, D. Wang, R. Dressel, A. Seltsam, R. Blasczyk, B. Eiz-Vesper: Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells. Blood (2009)

[21] L. Zender, W. Xue, J. Zuber, C.P. Semighini, A. Krasnitz, B. Ma, P. Zender, S. Kubicka, J.M. Luk, P. Schirmacher, W.R. McCombie, M. Wigler, J. Hicks, G.J. Hannon, S. Powers, S.W. Lowe: An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell (2008)

[22] T. Thum, C. Gross, J. Fiedler, T. Fischer, S. Kissler, M. Bussen, P. Galuppo, S. Just, W. Rottbauer, S. Frantz, M. Castoldi, J. Soutschek, V. Koteliansky, A. Rosenwald, M.A. Basson, J.D. Licht, J.T. Pena, S.H. Rouhanifard, M.U. Muckenthaler, T. Tuschl, G.R. Martin, J. Bauersachs, S. Engelhardt: MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature (2008)

[23] C. Mauritz, K. Schwanke, M. Reppel, S. Neef, K. Katsirntaki, L.S. Maier, F. Nguemo, S. Menke, M. Haustein, J. Hescheler, G. Hasenfuss, U. Martin: Generation of functional murine cardiac myocytes from induced pluripotent stem cells. Circulation (2008)

[24] V. Krizhanovsky, M. Yon, R.A. Dickins, S. Hearn, J. Simon, C. Miething, H. Yee, L. Zender, S.W. Lowe: Senescence of activated stellate cells limits liver fibrosis. Cell (2008)

[25] D. Fraccarollo, J.D. Widder, P. Galuppo, T. Thum, D. Tsikas, M. Hoffmann, H. Ruetten, G. Ertl, J. Bauersachs: Improvement in left ventricular remodeling by the endothelial nitric oxide synthase enhancer AVE9488 after experimental myocardial infarction. Circulation (2008)

[26] W. Xue, L. Zender, C. Miething, R.A. Dickins, E. Hernando, V. Krizhanovsky, C. Cordon-Cardo, S.W. Lowe: Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas. Nature (2007)

[27] L. Venturini, K. Battmer, M. Castoldi, B. Schultheis, A. Hochhaus, M.U. Muckenthaler, A. Ganser, M. Eder, M. Scherr: Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells. Blood (2007)

[28] T. Thum, S. Hoeber, S. Froese, I. Klink, D.O. Stichtenoth, P. Galuppo, M. Jakob, D. Tsikas, S.D. Anker, P.A. Poole-Wilson, J. Borlak, G. Ertl, J. Bauersachs: Age-dependent impairment of endothelial progenitor cells is corrected by growth-hormone-mediated increase of insulin-like growth-factor-1, Circ Res (2007)

[29] B. Schiedlmeier, A.C. Santos, A. Ribeiro, N. Moncaut, D. Lesinski, H. Auer, K. Kornacker, W. Ostertag, C. Baum, M. Mallo, H. Klump: HOXB4's road map to stem cell expansion.Proc Natl Acad Sci USA (2007)

[30] J. Heineke, M. Auger-Messier, J. Xu, T. Oka, M.A. Sargent, A. York, R. Klevitsky, S. Vaikunth, S.A. Duncan, B.J. Aronow, J. Robbins, T.M. Crombleholme, J.D. Molkentin: Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest (2007)

Most important publications Area B (Enabling Technologies)

[1] C. Stoll, H. Stadnick, O. Kollas, J.L. Holovati, B. Glasmacher, J.P. Acker, W.F. Wolkers: Liposomes alter thermal phase behavior and composition of red blood cell membranes. Biochim Biophys Acta (2011)

[2] C.L. Sajti, A. Barchanski, P. Wagener, S. Klein, S. Barcikowski: Delay Time and Concentration Effects During Bioconjugation of Nanosecond Laser-Generated Nanoparticles in a Liquid Flow. J Phys Chem C (2011)

[3] J. Palecek, G. Drager, R. Zweigerdt, R. Olmer, U. Martin, A. Kirschning: A practical synthesis of Rho-Kinase inhibitor Y-27632 and fluoro derivatives and thei9r evaluation in human pluripotent stem cells. Org Biomol Chem (2011)

[4] A. Ovsianikov, M. Malinauskas, S. Schlie, B. Chichkov, S. Gittard, R. Narayan, M. Lobler, K. Sternberg, K.P. Schmitz, A. Haverich: Three-dimensional laser micro- and nano-structuring of acrylated poly(ethylene glycol) materials and evaluation of their cytoxicity for tissue engineering applications. Acta Biomater (2011)

[5] A. Ovsianikov, A. Deiwick, S. Van Vlierberghe, P. Dubruel, L. Moller, G. Drager, B. Chichkov: Laser Fabrication of Three-Dimensional CAD Scaffolds from Photosensitive Gelatin for Applications in Tissue Engineering. Biomacromolecules (2011)

[6] R.A. Lorbeer, M. Heidrich, C. Lorbeer, D.F.R. Ojeda, G. Bicker, H. Meyer, A. Heisterkamp: Highly efficient 3D flurescence microscopy with a scanning laser optical tomograph. Opt Express (2011)

[7] K. Kuetemeyer, G. Kensah, M. Heidrich, H. Meyer, U. Martin, I. Gruh, A. Heisterkamp: Two-photon induced cross-linking in bioartifical cardiac tissue. Opt Express (2011)

[8] G. Kensah, I. Gruh, J. Viering, H. Schumann, J. Dahlmann, H. Meyer, D. Skvorc, A. Bar, P. Akhyari, A. Heisterkamp, A. Haverich, U. Martin: A Novel Miniaturized Multimodal Bioreactor for Continuous In Situ Assessment of Bioartificial Cardiac Tissue During Stimulation and Maturation. Tissue Eng Part C-Me (2011)

[9] M. Gruene, M. Pflaum, C. Hess, S. Diamantouros, S. Schlie, A. Deiwick, L. Koch, M. Wilhelmi, S. Jockenhoevel, A. Haverich, B. Chichkov: Laser Printing of Three-Dimensional Multicellular Arrays for Studies of Cell-Cell and Cell-Environment Interactions. Tissue Eng Part C Methods (2011)

[10] M. Gruene, A. Deiwick, L. Koch, S. Schlie, C. Unger, N. Hofmann, I. Bernemann, B. Glasmacher, B. Chichkov: Laser Printing of Stem Cells for Biofabrication of Scaffold-Free Autologous Grafts Tissue Eng Part C-Me (2011)

[11] B.B. Frericks, A.A. Kuhl, C. Loddenkemper, A. Stroux, S. Valdeig, B. Hotz, B. Misselwitz, J.C. Hoffmann, F.K. Wacker: Gadofluorine M-enhanced Magnetic Resonance Imaging of Inflammatory Bowel disease. Invest Radiol (2011)

[12] R. Dehn, Y. Katsuyama, A. Weber, K. Gerth, R. Jansen, H. Steinmetz, G. Hofle, R. Muller, A. Kirschning: Molecular Basis of Elansolid Biosynthesis: Evidence for an Unprecedented Quinone Methide Initiated Intramolecular Diels-Alder  Cycloaddition/Macrolactonization. Angew Chem Int Edit (2011)

[13] C. Bals, A. Schambach, J. Meyer, T. Scheper, U. Rinas: Expression and purification of bioactive soluble murine stem cell factor from recombinant Escherichia coli using thioredoxin as fusion partner. J Biotechnol (2011)

[14] M. Akhoondi, H. Oldenhof, C. Stoll, H. Sieme, W.F. Wolkers: Membrane hydraulic permeability changes during cooling of mammalian cells. Biochim Biophys Acta (2011)

[15] B. Stauch, B. Simon, T. Basile, G. Schneider, N.P. Malek, M. Kalesse, T. Carlomagno: Elucidation of the Structure and Intermolecular Interactions  of a Reversible Cyclic-Peptide Inhibitor of the Proteasome by NMR Spectroscopy and Molecular Modeling. Angew Chem Int Edit (2010)

[16] C.L. Sajti, R. Sattari, B.N. Chichkov, S. Barcikowski: Gram Scale Synthesis of Pure Ceramic Nanoparticles by Laser Ablation in Liquid. J Phys Chem C (2010)

[17] R.J. Narayan, A. Doraiswamy, D.B. Chrisey, B.N. Chichkov: Medical prototyping using two photon polymerization. Mater Today (2010)

[18] K. Kuetemeyer, A. Lucas-Hahn, B. Petersen, E. Lemme, P. Hassel, H. Niemann, A. Heisterkamp: Combined multiphoton imaging and automated functional enucleation of porcine oocytes using femtosecond laser pulses, J Biomed Opt (2010)

[19] L. Koch, S. Kuhn, H. Sorg, M. Gruene, S. Schlie, R. Gaebel, B. Polchow, K. Reimers, S. Stoelting, N. Ma, P.M. Vogt, G. Steinhoff, B. Chichkov: Laser Printing of Skin Cells and Human Stem Cells. Tissue Eng Part C Me (2010)

[20] C. Hess, B. Wiegmann, A.N. Maurer, P. Fischer, L. Moller, U. Martin, A. Hilfiker, A. Haverich, S. Fischer: Reduced Thrombocyte Adhesion to Endothelialized Poly 4-Methyl-1-Pentene Gas Exchange Membranes-A First Step Toward Bioartificial Lung Development. Tissue Eng Pt A (2010)

[21] J. Baumgart, W. Bintig, A. Ngezahayo, H. Lubatschowski, A. Heisterkamp: Fs-laser-induced Ca2+ concentration change during membrane perforation for cell transfection. Opt Express (2010)

[22] W.H. Roos, K. Radtke, E. Kniesmeijer, H. Geertsema, B. Sodeik, G.J. Wuite: Scaffold expulsion and genome packaging trigger stabilization of herpes simplex virus capsids. Proc Natl Acad Sci USA (2009)

[23] M. Farsari, B.N. Chichkov: Two-photon fabrication. Nat Photonics (2009)

[24] F.M. Bengel, T. Higuchi, M.S. Javadi, R. Lautamaki: Cardiac Positron Emission Tomography. J Am Coll
Cardiol (2009)

[25] H. Baraki, I. Tudorache, M. Braun, K. Hoffler, A. Gorler, A. Lichtenberg, C. Bara, A. Calistru, G. Brandes, M. Hewicker-Trautwein, A. Hilfiker, A. Haverich, S. Cebotari: Orthotopic replacement of the aortic valve with decellularized allograft in a sheep model. Biomaterials (2009)

[26] A. Ovsianikov, J. Viertl, B. Chichkov, M. Oubaha, B. MacCraith, I. Sakellari, A. Giakoumaki, D. Gray, M. Vamvakaki, M. Farsari, C. Fotakis: Ultra-low shrinkage hybrid photosensitive material for two-photon polymerization microfabrication. ACS Nano (2008)

[27] M.T. Figge, A. Garin, M. Gunzer, M. Kosco-Vilbois, K.M. Toellner, M. Meyer-Hermann: Deriving a germinal center lymphocyte migration model from two-photon data. J Exp Med (2008)

[28] V. Dinca, E. Kasotakis, J. Catherine, A. Mourka, A. Ranella, A. Ovsianikov, B.N. Chichkov, M. Farsari, A. Mitraki, C. Fotakis: Directed three-dimensional patterning of self-assembled peptide fibrils. Nano Lett (2008)

[29] S. Berski, J. van Bergeijk, D. Schwarzer, Y. Stark, C. Kasper, T. Scheper, C. Grothe, R. Gerardy-Schahn, A. Kirschning, G. Drager: Synthesis and biological evaluation of a polysialic acid-based hydrogel as enzymatically degradable scaffold material for tissue engineering. Biomacromolecules (2008)

[30] A. Ovsianikov, S. Schlie, A. Ngezahayo, A. Haverich, B.N. Chichkov: Two-photon polymerization technique for microfabrication of CAD-designed 3D scaffolds from commercially available photosensitive materials. J Tissue Eng Regen M (2007)

Most important publications Area C

[1] R. Zweigerdt, R. Olmer, H. Singh, A. Haverich, U. Martin: Scalable expansion of human pluripotent stem cells in suspension culture. Nat Protoc (2011)

[2] H. Wedemeyer, C. Yurdaydin, G.N. Dalekos, A. Erhardt, Y. Cakaloglu, H. Degertekin, S. Gurel, S. Zeuzem, K. Zachou, H. Bozkaya, A. Koch, T. Bock, H.P. Dienes, M.P. Manns: Peginterferon plus adefovir versus either drug alone for hepatitis delta. N Engl J Med (2011)

[3] H.E. von der Leyen, A. Mugge, C. Hanefeld, C.W. Hamm, M. Rau, H.J. Rupprecht, A.M. Zeiher, S. Fichtlscherer: A Prospective, Single-Blind, Multicenter, Dose Escalation Study of Intracoronary iNOS Lipoplex (CAR-MP583) Gene Therapy for the Prevention of Restenosis in Patients with de novo or Restenotic Coronary Artery Lesion (REGENT I Extension). Hum Gene Ther (2011)

[4] D. Strech: Incomplete registration and selective publication of clinical trials. A critical appraisal of normative arguments and new solutions. J Clin Epidemiol (2011)

[5] G. Salguero, B.S. Sundarasetty, S. Borchers, D. Wedekind, B. Eiz-Vesper, S. Velaga, A.C. Jirmo, G. Behrens, G. Warnecke, A.K. Knofel, R. Blasczyk, E. Mischak-Weissinger, A. Ganser, R. Stripecke: Preconditioning Therapy with Lentiviral Vector-Programmed DEndritic Cells accelerates the Homeostatic expansion. Hum Gene Ther (2011)

[6] N. Hoppe, A. Denoon: An ethical framework for expanded access to cell-based therapies. Regen Med (2011)

[7] J. Hauschild, B. Petersen, Y. Santiago, A.L. Queisser, J.W. Carnwath, A. Lucas-Hahn, L. Zhang, X. Meng, P.D. Gregory, R. Schwinzer, G.J. Cost, H. Niemann: Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci USA (2011)

[8] T. Hatlapatka, P. Moretti, A. Lavrentieva, R. Hass, N. Marquardt, R. Jacobs, C. Kasper: Optimization of culture conditions for the expansion of umbilical cord-derived mesenchymal stem or stromal cell-like cells using xeno-free culture conditions. Tissue Eng Part C Methods (2011)

[9] S. Cebotari, I. Tudorache, A. Ciubotaru, D. Boethig, S. Sarikouch, A. Goerler, A. Lichtenberg, E. Cheptanaru, S. Barnaciuc, A. Cazacu, O. Maliga, O. Repin, L. Maniuc, T. Breymann, A. Haverich: The Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement Reduces the Reoperation Rate in Children and Young Adults – Early Report. Circulation (2011) 

[10] M. Carrondo, A. Panet, D. Wirth, A.S. Coroadinha, P. Cruz, H. Falk, R. Schucht, F. Dupont, C. Geny-Fiamma, O.W. Merten, H. Hauser: Integrated strategy for the production of therapeutic retroviral vectors. Hum Gene Ther (2011)

[11] K.C. Wollert, H. Drexler: Cell therapy for the treatment of coronary heart disease: a critical appraisal. Nat Rev Cardiol (2010)

[12] C. Voelkel, M. Galla, T. Maetzig, E. Warlich, J. Kuehle, D. Zychlinski, J. Bode, T. Cantz, A. Schambach, C.
Baum: Protein transduction from retroviral Gag precursors. Proc Natl Acad Sci USA (2010)

[13] R. Tehranchi, P.S. Woll, K. Anderson, N. Buza-Vidas, T. Mizukami, A.J. Mead, I. Astrand-Grundstrom, B. Strombeck, A. Horvat, H. Ferry, R.S. Dhanda, R. Hast, T. Ryden, P. Vyas, G. Gohring, B. Schlegelberger, B. Johansson, E. Hellstrom-Lindberg, A. List, L. Nilsson, S.E. Jacobsen: Persistent malignant stem cells in del[5q] myeloysplasia in remision. N Engl J Med (2010)

[14] S. Stein, M.G. Ott, S. Schultze-Strasser, A. Jauch, B. Burwinkel, A. Kinner, M. Schmidt, A. Kramer, J. Schwable, H. Glimm, U. Koehl, C. Preiss, C. Ball, H. Martin, G. Gohring, K. Schwarzwaelder, W.K. Hofmann, K. Karakaya, S. Tchatchou, R. Yang, P. Reinecke, K. Kuhlcke, B. Schlegelberger, A.J. Thrasher, D. Hoelzer, R. Seger, C. von Kalle, M. Grez: Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med (2010)

[15] H. Singh, P. Mok, T. Balakrishnan, S.N. Rahmat, R. Zweigerdt: Up-scaling single cell-inoculated suspension culture of human embryonic stem cells. Stem Cell Res (2010)

[16] K.M. Olsson, A. Simon, M. Strueber, J. Hadem, O. Wiesner, J. Gottlieb, T. Fuehner, S. Fischer, G. Warnecke, C. Kuhn, A. Haverich, T. Welte, M.M. Hoeper: Extracorporeal membrane oxygenation in nonintubated patients as bridge to lung transplantation. Am J Transplant (2010) 

[17] R. Olmer, A. Haase, S. Merkert, W. Cui, J. Palecek, C. Ran, A. Kirschning, T. Scheper, S. Glage, K. Miller, E.C. Curnow, E.S. Hayes, U. Martin: Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium. Stem Cell Res (2010)

[18] T. May, M. Butueva, S. Bantner, D. Markusic, J. Seppen, R.A. MacLeod, H. Weich, H. Hauser, D. Wirth: Synthetic gene regulation circuits for control of cell expansion. Tissue Eng Part A (2010)

[19] G. Gohring, K. Michalova, H.B. Beverloo, D. Betts, J. Harbott, O.A. Haas, G. Kerndrup, L. Sainati, E. Bergstraesser, H. Hasle, J. Stary, M. Trebo, M.M. van den Heuvel-Eibrink, M. Zecca, E.R. van Wering, A. Fischer, P. Noellke, B. Strahm, F. Locatelli, C.M. Niemeyer, B. Schlegelberger: Complex karyotype newly defined the strongest prognostic factor in advanced childhood myelodysplastic syndrome. Blood (2010)

[20] K. Boztug, M. Schmidt, A. Schwarzer, P.P. Banerjee, I.A. Diez, R.A. Dewey, M. Bohm, A. Nowrouzi, C.R. Ball, H. Glimm, S. Naundorf, K. Kuhlcke, R. Blasczyk, I. Kondratenko, L. Marodi, J.S. Orange, C. von Kalle, C. Klein: Stem-cell gene therapy for the Wiskott-Aldrich-Syndrome. N Engl J Med (2010)

[21] U. Modlich, S. Navarro, D. Zychlinski, T. Maetzig, S. Knoess, M.H. Brugman, A. Schambach, S. Charrier, A. Galy, A.J. Thrasher, J. Bueren, C. Baum: Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors. Mol Ther (2009)

[22] G.P. Meyer, K.C. Wollert, J. Lotz, J. Pirr, U. Rager, P. Lippolt, A. Hahn, S. Fichtner, A. Schaefer, L. Arseniev, A. Ganser, H. Drexler: Intracoronary bone marrow cell transfer after myocardial infarction 5 year follow up from the randomized BOOST trial. Eur Heart J (2009)

[23] A. Melk, B.M. Schmidt, H. Braun, A. Vongwiwatana, J. Urmson, L.F. Zhu, D. Rayner, P.F. Halloran: Effects of donor age and cell senescence on kidney allograft survival. Am J Transplant (2009)

[24] O.S. Kustikova, B. Schiedlmeier, M.H. Brugman, M. Stahlhut, S. Bartels, Z. Li, C. Baum: Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis. Mol Ther (2009)

[25] E.O. Glocker, D. Kotlarz, K. Boztug, E.M. Gertz, A.A. Schaffer, F. Noyan, M. Perro, J. Diestelhorst, A. Allroth, D. Murugan, N. Hatscher, D. Pfeifer, K.W. Sykora, M. Sauer, H. Kreipe, M. Lacher, R. Nustede, C. Woellner, U. Baumann, U. Salzer, S. Koletzko, N. Shah, A.W. Segal, A. Sauerbrey, S. Buderus, S.B. Snapper, B. Grimbacher, C. Klein: Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med (2009)

[26] K. Boztug, G. Appaswamy, A. Ashikov, A.A. Schaffer, U. Salzer, J. Diestelhorst, M. Germeshausen, G. Brandes, J. Lee-Gossler, F. Noyan, A.K. Gatzke, M. Minkov, J. Greil, C. Kratz, T. Petropoulou, I. Pellier, C. Bellanne-Chantelot, N. Rezaei, K. Monkemoller, N. Irani-Hakimeh, H. Bakker, R. Gerardy-Schahn, C. Zeidler, B. Grimbacher, K. Welte, C. Klein: A syndrome with congenital neutropenia and mutations in G6PC3. N Engl J Med (2009)

[27] S.I. Thornhill, A. Schambach, S.J. Howe, M. Ulaganathan, E. Grassman, D. Williams, B. Schiedlmeier, N.J. Sebire, H.B. Gaspar, C. Kinnon, C. Baum, A.J. Thrasher: Self-inactivating gammaretroviral vectors for gene therapy of X-linked severe combined immunodeficiency. Mol Ther (2008)

[28] D. Strech, J. Tilburt: Value judgments in the analysis and synthesis of evidence. J of Clin Epidemiol (2008)

[29] R.F. Schlenk, K. Dohner, J. Krauter, S. Frohling, A. Corbacioglu, L. Bullinger, M. Habdank, D. Spath, M. Morgan, A. Benner, B. Schlegelberger, G. Heil, A. Ganser, H. Dohner: Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. N Engl J Med (2008)

[30] I. Nickeleit, S. Zender, F. Sasse, R. Geffers, G. Brandes, I. Sorensen, H. Steinmetz, S. Kubicka, T. Carlomagno, D. Menche, I. Gutgemann, J. Buer, A. Gossler, M.P. Manns, M. Kalesse, R. Frank, N.P. Malek: Argyrin a reveals a critical role for the the tumor suppressor protein p27 (kip1) in mediating antitumor activities. Cancer Cell (2008)

Recruitments

Habilitation (postdoctoral lecturing qualification)

Promotionen (PhD Graduations) PhD-Program "Regenerative Sciences"

Gender equality and family-oriented REBIRTH

The “Ina-Pichlmayr-Mentoring programme“ for 20 female scientists each year provides training for career development. The programme offered by the MHH-Department for Equal Opportunities is already in its 5th year: More than 100 female scientists have successfully completed this programme, supported by REBIRTH. 

Financial support from REBIRTH has enabled an additional nursery teacher to be employed at the 
"Die Hirtenkinder" day-care facility, which is open from 7.00 a.m. till 6.00 p.m. REBIRTH parents are offered places at this facility on a preferential basis, enabling them to be highly flexible in their working hours.

The supervisory agreement of the Ph.D. programme Regenerative Sciences explicitly covers the reconciliation of family and academic commitments: Ph.D. students with family duties receive organisational and financial support.

The Department of Cardiology and Angiology at Hannover Medical School (MHH) currently has a vacant professorship in Vascular Surgery and Biomedical Gender Studies. This post receives funding from Lower Saxony’s Ministry of Science and Culture under the Maria-Goeppert-Mayer Programme. The aim of Maria-Goeppert-Mayer professorships is to strengthen gender research at Lower Saxony’s institutions of higher education with specific reference to their own research priorities. REBIRTH will be providing additional resources to help fund this position.