miRNA in Liver Regeneration

Objectives

Our scientific vision is to achieve treatment of end-stage liver diseases, through interdisciplinary collaborations among REBIRTH research groups. The identification of novel cues that enable generation, expansion and proliferation of hepatocytes hold immense potential for the treatment of end stage liver diseases. Specifically, we are investigating novel regulatory molecules such as microRNAs (miRNAs) and transcription factors in liver regeneration and hepatocyte differentiation using novel cell and molecular biology techniques.

Research Focus

Compelling evidence from mouse liver regeneration and serial transplantation studies strongly indicates that adult hepatocytes retain their ability to proliferate in vivo. We seek to understand hepatocyte proliferation at the molecular level with a specific focus on miRNAs. We aim to harness the potential of miRNAs for improving hepatocyte proliferation in vitro and in vivo. Another focus of our research group is to improve hepatocyte differentiation from stem cells sources using miRNAs and transcription factors as modulators of hepatocyte differentiation.

Our interdisciplinary collaborations with other REBIRTH research groups, provides us with valuable tools and resources to achieve our objectives and expand our research focus.

Collaborations

Awards

  • A. Sharma, German association of study of liver diseases “(GASL)-Prize of YAEL Foundation” 2017.
  • A. Sharma, “Publication of the year award” by German Stem Cell Network 2016 (Publication: Direct reprogramming of hepatic myofibroblasts into heptocytes in vivo attenuates liver fibrosis. Cell Stem Cell, 2016).
  • D. Yang, HBRS Best PhD Prize, 2016.
  • A. Sharma, travel grant at the FASEB liver conference, Florida, USA 2016.
  • G. Song, travel grant at the FALK symposium, Düsseldorf, 2016.
  • J. Tsay, travel grant at the EASL, Spain, 2016.
  • M. Farid, travel grant at the EASL, Spain, 2016.
  • A. Sharma, award from “Gilead Sciences International Research Scholars Program in liver diseases” 2013.
  • S. Möbus, poster award at the “MicroRNAs Europe & Single Molecule Biology Europe-Meeting” 2012.
  • A. Sharma, poster award at the “17th HILF symposium MHH” 2011.

Teaching

  • Lecturer in the Regenerative Medicine PhD program.

Equipment and Service Facilities

[Please find a list of all available equipment here]

Publications

[Please find the publications of this workgroup here]