Embryonic Stem Cells

In the second funding period, this research project will be pursued within Unit 6.3 Tolerogenic Cell Therapy.

Objectives

The main focus of the Service Unit ESC is placed on cultivation, differentiation and characterization of embryonal stem cells and reprogrammed somatic cells especially of the large animal model common marmoset monkey (Callithrix jacchus).

Research Focus

The SUESC is investigating the large animal model common marmoset as a model for stem cell research and transplantation. In our research focus is cultivation, reprogramming and cryopreservation of non-human primate stem cells as a direct translation to the human. Furthermore, we are interested in differentiation of stem cells into pancreatic progenitor cells for future diabetes applications.

Collaborations

  • S. Schlatt, Münster, Center for Reproductive Medicine and Andrology, Tissue transfer and transplantation experiments in the marmoset monkey
  • A. Schambach, Hannover Medical School, Experimental Hematology, Exchange of lentiviral and episomal vector systems
  • B. Eiz-Vesper, Hannover Medical School, Transfusion Medicine, Identification of marmoset LA-peptide motives for the development of an allogeneic immune therapy
  • E. Sasaki, Kawasaki, Japan, Central Institute for Experimental Animals, Reprogramming of somatic cells into iPS cells, establishment of common marmoset diabetes model
  • W. Wolkers, Leibniz University of Hannover, Institute for Multiphase Processes, Cryopreservation of ESC and MEF cells

Awards

  • Jessica Rößler, Ulf Diekmann and 15 further graduate students were selected from a choice of 704 applicants for the Ph.D. programme Regenerative Sciences.

Teaching

  • Teacher academy, 2009: “Stem cell research of the SUESC”
  • Future day, 2009: “Stem cell research and science”
  • Central Institute for experimental animals(CIEA), Kawasaki, Japan 2009: “The cryobiology of mouse embryonic feeder cells”
  • Institute for Molecular Embryology and Genetics, University of Kumamoto, Japan, 2009: „The common marmoset – a top animal model for regenerative medicine”
  • Reg Sci PhD Program 2009 “Principles of stem cell Biology I & II”
  • ZKBS expert commission, Hannover, 2009: „Genetic security assessment of non-human primate cells”
  • Society of low temperature biology (SLTB), Hannover, 2009: “Cryoconservation in stem cell research – an underestimated area in translational medicine”
  • Society of low temperature biology (SLTB), Hannover, 2009: “Effects of cryoconservation on gamma-irradiated mouse embryonic feeder cells”
  • ESGCT Meeting, Hannover, 2009, Hannover: “Marmoset embryonic stem cells differentiated into insulin-producing cells offer great potential for a translational large animal model”
  • Future day 2010: “Stem cell research and science”
  • Discussions in Transfusion Medicine, Hannover, 2010: “Induced Pluripotent Stem Cells (iPS) – Potential for Regenerative Medicine”
  • Fakultas Kedokteran Universitas Indonesia (FKUI), Indonesia, 2010: "iPs – from Yamanaka to piPS and establishing ESC line for reproductive researches”
  • CME-Biomedik (FKUI), Indonesia, 2010: “Milestones, ethical hurdles, and usage of human ESC ”
  • RSCM Stem Cell Update FKUI, Indonesia, 2010: "Methods to induce pluripotency in somatic cell types" & meet the expert session
  • German-Indonesian Society for Medicine (DIGM), 2010, Indonesia: "Reprogramming of somatic cell types - prime time for iPS cells ?"

Equipment and Service Facilities

[Please find a list of all available equipment here]

Publications

[Please find the publications of this workgroup here]

Staff

Dr. Thomas Müller Mueller.Thomas (at) mh-hannover.de
Jessica Rößler Roessler.Jessica (at) mh-hannover.de
Ulf Diekmann Diekmann.Ulf (at) mh-hannover.de
Radiana Antarianto Antarianto.Radiana(at) mh-hannover.de
Stanislav Kraus Kraus.Stanislav (at) mh-hannover.de
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