REBIRTH Members

Moritz, Thomas

Moritz, Thomas, Prof. Dr. med.

Work Group Leader

REBIRTH Unit iPSC based Haematopoietic Regeneration

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

Moritz.Thomas(at)mh-hannover.de

Biography / About

Date of Birth:June, 1959
Function:Group leader

Education:

1985 - 1986Research Fellow in Virology/Immunology, German Cancer Research Center, Department of Tumorvirusimmunology, Heidelberg, Germany
1986 - 1991Internal Medicine & Hematology/Oncology, Department of Internal Medicine (Cancer Research), West German Cancer Center, University of Essen Medical School, Essen, Germany
1991 - 1994Postdoctoral Research Fellowship in Experimental Hematology, Herman B Wells Center for Pediatric Research, Indiana University, Indianapolis, USA
1995 - 1998Continued training in Internal Medicine and Hematology/Oncology, University of Essen Medical School, Germany
10/1998German Board of Internal Medicine
07/2000German Board of Oncology and Hematology

Academic appointments and Research posts:

1998 - 2000Instructor in Internal Medicine, University of Essen Medical School
2000 - 2009Lecturer in Internal Medicine, Hematology and Oncology, and Experimental Hematology, University of Essen Medical School
2005 - 2010Adjunct Associate Professor of Pediatrics, Department of Experimental Hematology, Cincinnati Children’s Hospital Medical Center Cincinnati, OH
Since 2006Professor of Internal Medicine (extraordinary), University of Duisburg-Essen Medical School
Since 2009Director, Reprogramming and Gene Therapy Group, REBIRTH Cluster-of-excellence, MHH Hannover

Other professional activities:

2000 - 2009Attending Physician (Oberarzt), Department of Internal Medicine (Cancer Research), West German Cancer Center, University of Essen Medical School
2004 - 2009Director: Clinical Stem Cell Laboratory, Department of Internal Medicine, University of Essen Medical School

Awards and Prizes:

1981 - 1982German Academic Exchange Service DAAD: Student Scholarship
1985 - 1986German Research Society (DFG): Trainee Scholarship
1991 - 1993German Cancer Aid – Dr. Mildred Scheel Stiftung: Dr. Mildred-Scheel Scholarship
1998Bennigsen Foerder Preis, Science Award for young scientist, Government of North-Rhine Westfalia
2002Science Award of the West German Cancer Center
2013Science Award of the Eva Louise and Horst Köhler Foundation for Rare Diseases

Major research interests:

  • Hematopoietic Gene Therapy
  • Hematopoietic and Pluripotent Stem Cell Research
  • Experimental Hematology
  • Macrophages
  • Alveolar Makrophages
  • Pulmonary diseases

Selected Publications:

  1. 1. Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T*, Lachmann N* (2016) “Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency”, Stem Cell Reports, Aug 9;7(2):292-305
  2. 2. Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T (2015) „Deoxycytidine-kinase (dCK) knock-down as a novel myeloprotective strategy in the context of fludarabine, cytarabine, or cladribine therapy“, Leukemia, 29:2266-69…
  3. Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Lüttge D, Buchegger T, Kühnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T (2015) “Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies.” Stem Cell Reports, 4 (2):282-96
  4. Müller-Kuller U*, Ackermann M*, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M (2015) “A minimal ubiquitous chromatin opening element (UCOE) effectively prevents silencing of juxtaposed heterologous promoters by epigenetic remodeling in multipotent and pluripotent stem cells.” Nucleic Acids Res, 43 (3):1577-92
  5. Suzuki T, Arumugam P, Sakagami T, Lachmann N, Chalk C, Sallese A, Abe S, Trapnell C, Carey B, Moritz T, Malik P, Lutzko C, Wood RE, Trapnell BC (2014) Pulmonary macrophage transplantation therapy. Nature, 514 (7523):450-4
  6. Happle C*, Lachmann N*, Skuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T*, Hansen G* (2014) Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Sci Transl Med, 6 (250):250ra113
  7. Phaltane R, Lachmann N, Brennig S, Ackermann M, Modlich U, Moritz T (2014) Lentiviral MGMTP140K-mediated in vivo selection employing a ubiquitous chromatin opening element (A2UCOE) linked to a cellular promoter. Biomaterials, 35 (25):7204-13
  8. Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Göhring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T (2014) Promoter and lineage independent anti-silencing activity of the A2 ubiquitous chromatin opening element for optimized human pluripotent stem cell-based gene therapy. Biomaterials, 35 (5):1531-42
  9. Lachmann N, Happle C, Ackermann M, Lüttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Göhring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T (2014) Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med, 189 (2):167-82
  10. Pfaff N*, Lachmann N*, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T (2013) “A Ubiquitous Chromatin Opening Element (UCOE) Sustains Cytidine Deaminase Expression and Drug Resistance in Murine iPSCs and Their Hematopoietic Progeny“. Stem Cells, 31 (3):488-99


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