REBIRTH Members

Hauser, Hansjörg

Hauser, Hansjörg, Dr. rer. nat.

Molecular Biotechnology

Helmholtz Centre for Infection Research
Mascheroder Weg 1
38124 Braunschweig

hansjoerg.hauser(at)helmholtz-hzi.de

Biography / About

Date of Birth:January, 1949

Education:

1968 - 1974Studies in Food Technology and Nutrition Sciences, Univ. Hohenheim
1977PhD in Biology, University of Konstanz
1978 - 1980Postgraduate studies; Max-Planck-Institute for Molecular Genetics; Berlin and German Cancer Research Centre, Heidelberg
1981 - 1985Research Scientist, Dept. of Genetics, GBF Braunschweig
1982EMBO Fellowship MRC in Mill Hill, London

Academic appointments and Research posts:

1986 - 1994Res. Group Leader "Genetics of Eukaryotes", GBF, Braunschweig
1994 - 2014Head of Dept „Gene Regulation and Differentiation", HZI, Braunschweig
1998 - 2010Head of Division “Molecular Biotechnology”, HZI, Braunschweig
Since 2002AAARP
YEARGuest Professor, University of Lisbon

Other professional activities:

  • Chairman, ESACT (European Society of Animal Cell Technology)
  • Chairman of Scientific Advisory Board, DSMZ (Deutsche Sammlung f. Mikroorganimen u. Zellkulturen)
  • Member of the Steering Committee, Excellence Cluster REBIRTH

Awards and Prizes:

2002Boltzmann Award (International Society for Interferon and Cytokine Research)

Major research interests:

  • Interferon system
  • Virology
  • Biotechnology Gene
  • Cell therapy

Selected Publications:

  1. Lipps C, Badar M, Butueva M, Dubic T, Singh VV, Rau, S, Weber A, Kracht M, Köster M, May T, Schulz T, Hauser H, Wirth D. Proliferation status defines functional properties of endothelial cells. CMLS. 2017;74(7):1319-33.
  2. Ochel A, Cebula M, Hillebrand U, Riehn M, Lipps C, Schirmbeck R., Hauser H, Wirth D. Effective intrahepatic CD8+ T cell immune responses are induced by low but not high numbers of antigen expressing hepatocytes. Cell Mol Immunol 2015;13(6):805–15.
  3. Dag F, Dölken L, Holzki J ,Drabig A,Weingärtner A, Schwerk S, Lienenklaus K, Conte I, Geffers R,Davenport C, Rand U, Köster M, Weiß S, Adler B, Wirth D, Messerle M, Hauser H, Cicin-Sain L. Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency. 2014. PLoS Path;10(2):e1003962.
  4. Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Köster M, Kalinke U, Hauser H, Kröger A. Interferon Regulatory Factor-1 protects from fatal neurotropic infection with Vesicular Stomatitis Virus by specific inhibition of viral replication in neurons. PLoS Pathog. 2014;10(3):e1003999.
  5. Rand U, Hillebrand U, Sievers S, Willenberg S, Köster M, Hauser H, Wirth D. Uncoupling of the dynamics of host-pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level. Nucl Acids Res. 2014;42(13):e109.
  6. Nandakumar R, Nair S, Neumann B, Finsterbusch K, Grashoff M, Hochnadel I, Lienenklaus, Wappler I, Steinmann E, Hauser H, Pietschmann T.Kröger A. Hepatitis C Virus replication in mouse cells is restricted by IFN-dependent and IFN-independent mechanisms. Gastro. 2013;145(6):1414-23.
  7. Rand U, Rinas M, Schwerk J, Nöhren G, Linnes M, Kröger A, Flossdorf M, Kály-Kullai K, Hauser H, Höfer T, Köster M. Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response. Mol Sys Biol. 2012; 8:584-96.
  8. Ksienzyk A, Neumann B, Nandakumar R, Finsterbusch K, Grashoff M, Zawatzky R. Bernhardt G, Hauser H, Kröger A. Interferon Regulatory Factor-1 expression promotes NK cell mediated suppression of metastases. Cancer Res.2011;71(20):6410-8.
  9. Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D. Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells. Nucl Acids Res. 2011;39(1):e1.
  10. Dietrich N, Rohde M, Geffers R, Kröger A, Hauser H, Weiss S, Gekara NO. Mast cells elicit pro-inflammatory but not type I interferon responses upon activation of TLRs by bacteria.Proc. Natl Acad Sci USA. 2010;107(19):8748-53.


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