Bleich, André

Bleich, André, Prof. Dr. med. vet.

Head of Department

Institute for Laboratory Animal Science

Biography / About

Date of Birth:September, 1974
Function:Director of the institute


2000/2001Hannover School of Veterinary Medicine, “Approbation als Tierarzt”
2003PhD, “Genetic Analysis of Susceptibility to Colitis in IL-10 Deficient Mice”, Hannover School of Veterinary Medicine/DFG-GRK705
2005German board certified specialist in laboratory animal science
2007Board certfied by the European College of Laboratory Animal Medicine
2009Venia legendi for Laboratory Animal Science, MHH

Academic appointments and Research posts:

2004 - 2012Head of health monitoring laboratories and research associate, Central Animal Facility and Institute for Laboratory Animal Science, MHH
2008Animal welfare commissioner, MHH
2009 - 2012Professor (W2) of Laboratory Animal Science, MHH
2012Professor (W3) and director of the Institute for Laboratory Animal Science and Central Animal Facility, MHH

Other professional activities:

Since 2006Member of the Working Group on Hygiene of GV-SOLAS
Since 2008Member of the scientific advisory board of the GV-SOLAS
Since 2010Member of the training committee of ECLAM
Since 2011Member of the examination committee of the European College of Laboratory Animal Medicine (ECLAM)
2015President of organizing committee, meeting of the Society of Laboratory Animal Science (GV-SOLAS) 2015

Awards and Prizes:

2001 - 2003DFG scholarship (GRK 705)
2017Coordinator of the research group “R2N – Replace and Reduce in Lower Saxony”
2017Coordinator of the DFG research group “Severity Assessment in animal based research” (FOR 2591) together with René Tolba

Major research interests:

  • Animal Welfare
  • Microbiome & Gnotobiology
  • Animal Models of IBD
  • Infection Models

Selected Publications:

  1. Buchheister S, Buettner M, Basic M, Noack A, Breves G, Buchen B, Keubler LM, Becker C, Bleich A. CD14 plays a protective role in experimental inflammatory bowel disease by enhancing intestinal barrier function. Am J Path. 2017;187: 1106e1120.
  2. Peuker K, Muff S, Wang J, Künzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Röcken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med. 2016 22(5):506-15.
  3. Keubler LM, Büttner M, Häger C, Bleich A. A multi-hit model: colitis lessons from the interleukin-10-deficient mouse. Inflamm Bowel Dis. 2015;21:1967-75.
  4. Häger C, Keubler LM, Biernot S, Dietrich J, Buchheister S, Buettner M, Bleich A. Time to Integrate to Nest Test Evaluation in a Mouse DSS-Colitis Model. PLoS One. 2015;10(12):e0143824. doi: 10.1371/journal.pone.0143824.
  5. Nicklas W, Keubler L, Bleich A. Maintaining and Monitoring the Defined Microbiota Status of Gnotobiotic Rodents. ILAR J. 2015;56(2):241-9.
  6. Lindner C, Thomsen I, Wahl B, Ugur M, Sethi M, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, Schreiber S, Bleich A, Cerf-Bensussan N, Hazanov H, Mehr R, Boysen P, Rosenstiel P and Pabst O. Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota. Nature Immunol. 2015;16:880-8.
  7. Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M. RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature. 2014;513(7516):90-4.
  8. Basic M, Keubler LM, Achard M, Breves G, Schröder B, Smoczek A, Jörns A, Wedekind D, Zschemisch NH, Neumann D, Lienenklaus S, Weiss S, Hornef MW, Mähler M, Bleich A. Norovirus triggered microbiota-driven mucosal inflammation in Interleukin 10-deficient mice. Inflamm Bowel Dis. 2014;20:431-43.
  9. Büchler G, Wos-Oxley ML, Smoczek A, Zschemisch NH, Neumann D, Pieper DH, Hedrich HJ, Bleich A. Strain specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota–host interactions. Inflamm Bowel Dis. 2012;18:943-54.
  10. Bleich A, Janus LM, Smoczek A, Westendorf AM, Strauch U, Mähler M, Hedrich HJ, Fichtner-Feigl S, Schölmerich J, Falk W, Hofmann C, Obermeier F. CpG motifs of bacterial DNA exert protective effects in mouse models of IBD by antigen-independent tolerance induction. Gastroenterology. 2009;136:278-287.

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