REBIRTH Members

Kirschning, Andreas

Kirschning, Andreas, Prof. Dr. rer. nat.

Natural Sciences; Institute of Organic Chemistry

Leibniz University of Hannover
Schneiderberg 1b
30167 Hannover

andreas.kirschning(at)oci.uni-hannover

Biosketch:

A. Kirschning (*1960), PhD, W3 professor for ‘Organic Chemistry’ and vice dean at the faculty of Natural Sciences of LUH is cofounder of the Center of Biomolecular Drug Research (BMWZ), the translational research center that links medicinal natural product chemistry with biomedical research between LUH, MHH and the Helmholtz Centers in Munich (HMGU) and in Braunschweig (HZI). His research focuses on medicinal natural product chemistry in combination with nanomedical research for creating drug conjugates for target specific drug delivery and externally triggered drug release. These expertises were extended to the development of hydrogels and biomedical materials and the specific functionalization with bioactive molecules and drugs.

Biography / About

Date of Birth:March, 1960
Function:Full (C4) Professor and Vice Dean of the Faculty of Natural Sciences, LUH

Education:

10/1980 - 08/1986Chemistry studies, Universität Hamburg, Germany
10/1983 - 07/1984Chemistry studies (BSc), Southampton University; UK
08/1986Master degree / master thesis, University Hamburg
04/1989PhD thesis, University Hamburg

Academic appointments and Research posts:

08/1989 - 10/1990Post-doctoral-research, University of Washington - Seattle, WA, USA
04/1991 - 06/1996Post-doctoral lecturing qualitfication (Habilitation), Technical University of Clausthal, Germany
Since 10/2000Full professor, Institute of Organic Chemistry, LUH

Other professional activities:

Since 1989Selection Commitee of the German Academic Scholarship Foundation (‘Studienstiftung des Deutschen Volkes’)
2001 - 2013Director of the Institute of Organic Chemistry, LUH
2002Cofounder of CHELONA GmbH, Potsdam
Since 2002Editor of ‘RÖMPP-online’
Since 2003Member of the Natural Product Forum; ‘DECHEMA’ (chairman since 2014)
Since 2006Editorial Board of ‘Beilstein Journal of Organic Chemistry’ (BJOC)
2007 - 2012Editorial Board of ‘Natural Product Reports’ (NPR)
Since 2015Vice Dean of the Faculty of Natural Sciences

Awards and Prizes:

1983 - 1984DAAD-study scholarship for UK
1989Fritz-Prosiegel-scholarship
1989 - 1990Feodor Lynen Research Fellowship of the Alexander von Humboldt Foundation
2013 - 2014Novartis Lectureship Award (13-14)

Major research interests:

  • Total-, semi- and mutasynthesis of natural products (antinfectives, antitumor agents)
  • ‘Enabling technologies’ in organic synthesis (microreactors, immobilization strategies)
  • Functionalized smart materials for regenerative therapies (tissue engineering implants etc.)

Furthermore:

Visiting and guest professorships:
Humboldt-Universität zu Berlin, Germany (1997), University of Wisconsin, WI, USA (1998), Université de Rennes, France (2003), Université Le Mans, France (April/May 2007), Università di Roma ‘La Sapienza’, Italy (October 2007), University Louis Pasteur Strasbourg, ECPM, France (February 2009, 2010, 2011).

Selected Publications:

  1. Wang LL, Balakrishnan A, Candito D, Xie Y, Seidel K, Ott M, Kirschning A. A bio-chemosynthetic approach to superparamagnetic iron oxide - ansamitocin conjugates for use in magnetic drug targeting (MDT). Chem Eur J. 2017. DOI: 10.1002/chem.201604903.
  2. Mancuso JL ,Knobloch T, Buchholz J, Hartwig J, Möller L, Seidel K, Collisi W, Sasse F, Kirschning A. Preparation of thermocleavable conjugates based on ansamitocin and superparamagnetic nanostructured particles by a chemo-biosynthetic approach. Chem Eur J. 2014. 20, 17541–17551.
  3. Hartwig J, Ceylan S, Kupracz L, Coutable L, Kirschning A. Heating under High Frequency Inductive Conditions: Application to the Continuous Synthesis of the Neurolepticum Olanzapine (Zyprexa®). Angew Chem. 2013. 125, 9995–9999; Angew. Chem. Int. Ed. 2013, 52, 9813–9817.
  4. Taft F, Harmrolfs K, Nickeleit I, Heutling A, Keine M, Malek N, Sasse F, Kirschning A, Combined Muta- and Semisynthesis: A Powerful Synthetic Hybrid Approach to Access Target Specific Antitumor Agents Based on Ansamitocin P3. Chem Eur J. 2012. 18, 880–886.
  5. Eichner S, Knobloch T, Floss HG, Fohrer J, Harmrolfs K, Hermane J, Schulz A, Sasse F, Spiteller P, Taft F, Kirschning A. The Interplay between Mutasynthesis and Semisynthesis: Generation and Evaluation of an Ansamitocin Library. Angew Chem. 2012. 124, 776–781; Angew. Chem. Int. Ed. 2012, 51, 752–757.
  6. Barbier J, Jansen R, Irschik H, Benson S, Gerth K, Böhlendorf B, Höfle G, Reichenbach H, Wegner J, Zeilinger C, Kirschning A, Müller R. Isolation and Total Synthesis of Icumazoles and Noricumazoles—Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum. Angew Chem. 2012. 124, 1282–1286; Angew. Chem. Int. Ed. 2012, 51, 1256–1260.
  7. Eichner S, Eichner T, Floss HG, Fohrer J, Hofer E, Sasse F, Zeilinger C, Kirschning A. Broad Substrate Specificity of the Amide Synthase in S. hygroscopicus -New 20-Membered Macrolactones Derived from Geldanamycin, J. Am. Chem. Soc. 2012, 134,1673–1679.
  8. Schmidt T, Kirschning A. Total Synthesis of Carolacton, a Highly Potent Biofilm Inhibitor. Angew Chem. 2012. 124, 1087–1091; Angew. Chem. Int. Ed. 2012, 51,1063–1066 (Highlighted in Synfacts02012, 8, 0363).
  9. Dehn R, Katsuyama Y, Weber A, Gerth K, Jansen R, Steinmetz H, Höfle G, Müller R, Kirschning A. Molecular basis of elansolid biosynthesis: evidence for an unprecedented quinone methide initiated intramolecular Diels-Alder cycloaddition / macrolactonization. Angew Chem. 2011. 123, 3968-3973; Angew. Chem. Int. Ed. 2011, 50, 3882–3887.
  10. 1Steinmetz H, Gerth K, Jansen R, Schläger N, Dehn R, Reinecke S, Höfle G, Kirschning A, Müller R. Elansolid A, a Unique Macrolide Antibiotic from Chitinophaga sancti is Accessible as Two Stable Atropisomers. Angew Chem. 2011. 123, 553-557; Angew. Chem. Int. Ed. 2011, 50, 532–536.


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