Krug, Norbert

Krug, Norbert, Prof. Dr. med.

Medical Head of Department

Study Team, Fraunhofer Institut für Toxikologie und Experimentelle Medizin

Biography / About

Date of Birth:July, 1960
Function:Executive Director Fraunhofer ITEM Coordinator Clinical Research Center, CRC Hannover


1989Medical Exam
1991Medical license acquired
1998Degree in Internal Medicine
1999Venia legendi in Internal Medicine
2000Degree in Respiratory Medicine
2000Full(C3) professor in Immunology, Allergology and Airway Research and Division Director at Fraunhofer ITEM
2001Degree in Allergy and Intensive Care Medicine
Since 2008Medical Director at Fraunhofer ITEM and Coordinator Clinical Research Center Hannover (W3)
Since 2017Executive Director at Fraunhofer ITEM

Other professional activities:

  • Reviewer for all major journals in respiratory medicine and allergy
  • Reviewer for German Research Council and Max-Planck-Society
  • Scientific advisory board of the German Society for Allergy and Clinical Immunology
  • Member of the German Center for Lung Research
  • Consultant for pharmaceutical industry (Asthma, allergic rhinitis, COPD)

Major research interests:

  • Translational research allergy, asthma and COPD
  • Pathogenesis of allergic airway diseases (asthma, rhinitis and COPD)
  • Air pollution and airway diseases

Selected Publications:

  1. Kuo CS, Pavlidis S, Loza M, Baribaud F, Rowe A, Pandis I, Hoda U, Rossios C, Sousa A, Wilson SJ, Howarth P, Dahlen B, Dahlen SE, Chanez P, Shaw D, Krug N, Sandström T, De Meulder B, Lefaudeux D, Fowler S, Fleming L, Corfield J, Auffray C, Sterk PJ, Djukanovic R, Guo Y, Adcock IM, Chung KF; U-BIOPRED Project Team.. A Transcriptome-driven Analysis of Epithelial Brushings and Bronchial Biopsies to Define Asthma Phenotypes in U-BIOPRED. Am J Respir Crit Care Med. 2016 Aug 31. [Epub ahead of print] PubMed PMID: 27580351.
  2. Werfel T, Heratizadeh A, Niebuhr M, Kapp A, Roesner LM, Karch A, Erpenbeck VJ, Lösche C, Jung T, Krug N, Badorrek P, Hohlfeld JM. Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber. J Allergy Clin Immunol. 2015 Jul;136(1):96-103.e9. doi: 10.1016/j.jaci.2015.04.015. PubMed PMID: 26044854.
  3. Krug N, Hohlfeld JM, Kirsten AM, Kornmann O, Beeh KM, Kappeler D, Korn S, Ignatenko S, Timmer W, Rogon C, Zeitvogel J, Zhang N, Bille J, Homburg U, Turowska A, Bachert C, Werfel T, Buhl R, Renz J, Garn H, Renz H. Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme. N Engl J Med. 2015 May 21;372(21):1987-95. doi: 10.1056/NEJMoa1411776. PubMed PMID: 25981191.
  4. Homburg U, Renz H, Timmer W, Hohlfeld JM, Seitz F, Lüer K, Mayer A, Wacker A, Schmidt O, Kuhlmann J, Turowska A, Roller J, Kutz K, Schlüter G, Krug N, Garn H. Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma. J Allergy Clin Immunol. 2015 Sep;136(3):797-800. doi: 10.1016/j.jaci.2015.02.018. PubMed PMID: 25842286.
  5. Schaumann F, Frömke C, Dijkstra D, Alessandrini F, Windt H, Karg E, Müller M, Winkler C, Braun A, Koch A, Hohlfeld JM, Behrendt H, Schmid O, Koch W, Schulz H, Krug N. Effects of ultrafine particles on the allergic inflammation in the lung of asthmatics: results of a double-blinded randomized cross-over clinical pilot study. Part Fibre Toxicol. 2014 Sep 10;11:39. doi: 10.1186/s12989-014-0039-3. PubMed PMID: 25204642; PubMed Central PMCID: PMC4354282.
  6. Vogel-Claussen J, Renne J, Hinrichs J, Schönfeld C, Gutberlet M, Schaumann F, Winkler C, Faulenbach C, Krug N, Wacker FK, Hohlfeld JM. Quantification of pulmonary inflammation after segmental allergen challenge using turbo-inversion recovery-magnitude magnetic resonance imaging. Am J Respir Crit Care Med. 2014 Mar 15;189(6):650-7. doi: 10.1164/rccm.201310-1825OC. PubMed PMID: 24401150.
  7. Krug N, Gupta A, Badorrek P, Koenen R, Mueller M, Pivovarova A, Hilbert J, Wetzel K, Hohlfeld JM, Wood C. Efficacy of the oral chemoattractant receptor homologous molecule on TH2 cells antagonist BI 671800 in patients with seasonal allergic rhinitis. J Allergy Clin Immunol. 2014 Feb;133(2):414-9. doi: 10.1016/j.jaci.2013.10.013. PubMed PMID: 24332218.
  8. Nicholson GC, Kariyawasam HH, Tan AJ, Hohlfeld JM, Quinn D, Walker C, Rodman D, Westwick J, Jurcevic S, Kon OM, Barnes PJ, Krug N, Hansel TT. The effects of an anti-IL-13 mAb on cytokine levels and nasal symptoms following nasal allergen challenge. J Allergy Clin Immunol. 2011 Oct;128(4):800-807.e9. doi: 10.1016/j.jaci.2011.05.013. PubMed PMID: 21719078.
  9. Woodruff PG, Wolff M, Hohlfeld JM, Krug N, Dransfield MT, Sutherland ER, Criner GJ, Kim V, Prasse A, Nivens MC, Tetzlaff K, Heilker R, Fahy JV. Safety and efficacy of an inhaled epidermal growth factor receptor inhibitor (BIBW 2948 BS) in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2010 Mar 1;181(5):438-45. doi: 10.1164/rccm.200909-1415OC. PubMed PMID: 20007923.
  10. Schaumann F, Müller M, Braun A, Luettig B, Peden DB, Hohlfeld JM, Krug N. Endotoxin augments myeloid dendritic cell influx into the airways in patients with allergic asthma. Am J Respir Crit Care Med. 2008 Jun 15;177(12):1307-13. doi: 10.1164/rccm.200706-870OC. PubMed PMID: 18388357; PubMed Central PMCID: PMC2427055.

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