REBIRTH Members

Maus, Ulrich

Maus, Ulrich, Prof. Dr. rer. nat.

Head of Department

Experimentel Pneumology, Hannover Medical School


Biography / About

Function:Head of the Department of Experimental Pneumology, Hannover Medical School (MHH)

Education:

1996PhD in Biology, clinical research group “Respiratory distress”, Center for Internal Medicine (Head: Prof. Dr. W. Seeger), Justus-Liebig-University Giessen
1997 - 1999Post-Doc and co-leader of project B3, SFB 547 “Cardiopulmonary Vascular System” (Speaker: Prof. Dr. W. Seeger), Justus-Liebig-University Giessen

Academic appointments and Research posts:

1999 - 2004Assistant Professor of Experimental Pneumology Project leader B3, SFB 547 “Cardiopulmonary Vascular System”, De-partment of Internal Medicine, JLU Giessen
2005Post-doctoral lecturing qualification (Habilitation) in Molecular Medicine
2009Professor (W3) for Experimental Pneumology, MHH
2009Head of the Department of Experimental Pneumology, MHH

Awards and Prizes:

1997Teaching Certificate der European School of Respiratory Society
2003Forschungspreis Grundlagenforschung der DGP
2015Forschungspreis Grundlagenforschung des LungenfibrO2e e.V.

Major research interests:

  • Pathobiology of lung bacterial and mycobacterial infections
  • Development of novel therapeutic concepts for the treatment of acute lung infections and diffuse parenchymal lung diseases

Selected Publications:

  1. von Wulffen W, Steinmueller M, Herold S, Marsh LM, Bulau P, Seeger W, Welte T, Lohmeyer J, Maus UA. Lung dendritic cells elicited by Fms-like tyrosine 3-kinase ligand amplify the lung inflammatory response to lipopolysaccharide. Am J Respir Crit Care Med 176:892-901, 2007.
  2. Denzel A, Maus UA, Gomez MR, Moll C, Niedermeier M, Winter C, Maus R, Hollingshead S, Briles DE, Kunz-Schughart LA, Talke Y, Mack M. Basophils enhance immunological memory responses. Nat Immunol 9:733-742, 2008.
  3. Steinwede K, Henken S, Bohling J, Maus R, Ueberberg B, Brumshagen C, Brincks EL, Griffith TS, Welte T, Maus UA. TNF-related apoptosis-inducing ligand (TRAIL) exerts therapeutic efficacy for the treatment of pneumococcal pneumonia in mice. J Exp Med 209:1937-1952, 2012.
  4. Weber M, Lambeck S, Ding N, Henken S, Kohl M, Deigner HP, Enot DP, Igwe EI, Frappart L, Kiehntopf M, Claus RA, Kamradt T, Weih D, Vodovotz Y, Briles DE, Ogunniyi AD, Paton JC, Maus UA*, Bauer M*. Hepatic induction of cholesterol biosynthesis reflects a remote adaptive response to pneumococcal pneumonia. FASEB J 26:2424-2436, 2012. (* Shared senior authorship).
  5. Bischof A, Brumshagen C, Ding N, Kirchhof G, Briles DE, Gessner JE, Welte T, Mack M, Maus UA. Basophil expansion protects against invasive pneumococcal disease in mice. J Infect Dis 210:14-24, 2014.
  6. Knippenberg S, Brumshagen C, Aschenbrenner F, Welte T, Maus UA. Arginase 1 activity worsens lung-protective immunity against Streptococcus pneumoniae infection. Eur J Immunol 45:1716-1726, 2015.
  7. Knippenberg S, Ueberberg B, Maus R, Bohling J, Ding N, Tort Tarres M, Hoymann HG, Jonigk D, Izykowski N, Paton JC, Ogunniyi AD, Lindig S, Bauer M, Welte T, Seeger W, Guenther A, Sisson TH, Gauldie J, Kolb M, Maus UA. Streptococcus pneumoniae triggers progression of pulmonary fibrosis through pneumolysin. Thorax 70:636-646, 2015.
  8. Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, Jonigk D, Izykowski N, Mägel L, Welte T, Yamasaki S, Maus UA. Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cells Contribute to Control of Splenic Mycobacterium bovis BCG Infection in Mice. Infect Immun 83: 184-196, 2015.
  9. Behler-Janbeck F, Takano T, Maus R, Stolper J, Jonigk D, Tort Tarrés M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, Yamasaki S, Maus UA. C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia. PLoS Pathog 12:e1006038, 2016.
  10. Dommaschk A, Ding N, Tort Tarres M, Bittersohl LF, Maus R, Stolper J, Jonigk D, Braubach P, Lippmann T, Welte T, Maus UA. Nasopharyngeal colonization with Streptococcus pneumoniae triggers dendritic cell dependent antibody responses against invasive disease in mice. Eur J Immunol 47:540-551, 2017.


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