REBIRTH Members

Naujok, Ortwin

Naujok, Ortwin, Dr. rer. nat.

Arbeitsgruppenleiter

REBIRTH Unit Differentation, Subgroup Biochemistry, Institute of Clinical Biochemistry, Hannover Medical School


Biography / About

Date of Birth:December, 1974
Function:Group leader

Education:

04/1996 - 09/1996Study of philosophy and history at the Leibniz Universität Hannover, Hannover, Germany
10/1996 - 05/2001Study of biology at the Leibniz Universität Hannover, Hannover, Germany
05/2002Final degree: Diploma in Biology. Diploma Thesis: „Charakterisierung apikaler Transportvesikel in polaren Endothelzellen“(“Characterization of apical transport vesicles in polar endothelial cells”), at the Department of Physiological Chemistry, University of Veterinary Medicine Hannover, Hannover, Germany

Academic appointments and Research posts:

Since 07/2002Research assistant at the Institute of Clinical Biochemistry, Hannover Medical School (MHH), Hannover, Germany
05/2008Dissertation to Dr. rer. nat. in biochemistry: „Differenzierung muriner embryonaler Stammzellen in insulinproduzierende Zellen“(“Differentiation of murine embryonic stem cells into insulin-producing cells”) writen at the Institute of Clinical Biochemistry, MHH, Hannover, Germany
01/2009Research fellow at the Institute of Clinical Biochemistry, MHH, Hannover, Germany
01/2011Advanced research fellow at the Institute of Clinical Biochemistry, MHH, Hannover Germany. Group leader: Cell replacement therapy unit
10/2014Professorial dissertation to Dr. rer. nat. habil. in biochemistry. Thesis title: „Embryonale Stammzellen als Ausgangsquelle für eine Zellersatztherapie des Diabetes mellitus“(„Embryonic stem cells as the starting source for a diabetic therapy of diabetes mellitus “).

Other professional activities:

  • Member of German Diabetes Association (DDG)
  • Member of European Association for the Study of Diabetes (EASD)

Awards and Prizes:

05/2009Sponsorship award of the German Diabetes Association
05/2015Ernst-Friedrich-Pfeiffer award of the German Diabetes Association

Major research interests:

  • Type 1 diabetes mellitus
  • Embryonic stem cells & induced pluripotent stem cells
  • Differentiation of embryonic stem cells and induced pluripotent stem cells
  • Cell replacement therapy of type 1 diabetes mellitus
  • TALEN and CRISP/Cas9-mediated genomic editing

Selected Publications:

  1. Davenport, C, Diekmann, U, Budde, I, Detering, N, Naujok, O: The anterior-posterior patterning of definitive endoderm generated from human embryonic stem cells depends on the differential signaling of retinoic acid, Wnt- and BMP-signaling. Stem Cells Jun 14, 2016 doi: 10.1002/stem.2428. [Epub ahead of print]
  2. Diekmann, U, Lenzen, S, Naujok, O: A reliable and efficient protocol for human pluripotent stem cell differentiation into the definitive endoderm based on dispersed single cells. Stem Cells Dev 24, 190-2042, 2015
  3. Naujok O, Diekmann U, Lenzen S: The generation of definitive endoderm from human embryonic stem cells is initially independent from activin A but requires canonical Wnt-signaling. Stem Cell Rev 10, 480-93, 2014
  4. Naujok O, Bandou Y, Shikama Y, Funaki M, Lenzen S: Effect of substrate rigidity in tissue culture on the function of insulin-secreting INS-1E cells. J Tissue Eng Regen Med 2014 Jan 8, doi: 10.1002/term.1857. (Epub ahead of print)
  5. Diekmann, U, Elsner, M, Fiedler, J, Thum, T, Lenzen, S, Naujok, O: MicroRNA Target Sites as Genetic Tools to Enhance Promoter-Reporter Specificity for the Purification of Pancreatic Progenitor Cells from Differentiated Embryonic Stem Cells. Stem Cell Rev 9, 555-568, 2013
  6. Lortz S, Gurgul-Convey E, Naujok O, Lenzen S: Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting cells. Diabetologia 56, 774-782, 2013
  7. Diekmann U, Naujok O, Blasczyk R, Müller T: Embryonic stem cells of the non-human primate Callithrix jacchus can be differentiated into definitive endoderm by Activin-A but not IDE-1/2. J Tissue Eng Regen Med 2013 Feb 18. doi: 10.1002/term.1709. (Epub ahead of print)
  8. Diekmann U, Elsner M, Fiedler J, Thum T, Lenzen S, Naujok O: MicroRNA target sites as genetic tools to enhance promoter-reporter specificity for the purification of pancreatic progenitor cells from differentiated embryonic stem cells. Stem Cell Rev 9, 555-68, 2013
  9. Naujok O, Lenzen S: A critical re-evaluation of CD24-positivity of human embryonic stem cells differentiated into pancreatic progenitors. Stem Cell Rev 8, 779-791, 2012
  10. Elsner M, Terbish T, Jörns A, Naujok O, Wedekind D, Hedrich HJ, Lenzen S: Reversal of diabetes through gene therapy of diabetic rats by hepatic insulin expression via lentiviral transduction. Mol Ther 20, 918-926, 2012


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