REBIRTH Members

Wirth, Dagmar

Wirth, Dagmar, PD Dr. rer. nat.

Work Group Leader

REBIRTH Unit Rational Cell Engineering Model Systems for Infections, Helmholtz Center for Infection Research


Biography / About

Date of Birth:January, 1963
Function:Group leader

Education:

1992 - 1987Studies in Chemistry, Technical University Braunschweig
1987 - 1996PhD work, Dept. Gene Regulation and Differentiation, GBF Braunschweig, Germany

Academic appointments and Research posts:

1991 - 1996PostDoc, Dept. of Gene Regulation and Differentiation, GBF Braunschweig
1999 - 2003Scientist, Dep. of Clinical Immunology, Medical School, Hannover
Since 2004Scientist, Helmholtz Centre for Infection Research, Braunschweig
Since 2007Leader of the research group: Model Systems for Infection and Immunity, Helmholtz Centre for Infection, Braunschweig
Since 2014Appointed professor; Medical University Hannover

Other professional activities:

1996 - 1998Freelance work, biomedical research

Major research interests:

  • Synthetic biology of cell systems for biomedical applications
  • Controlled cell expansion
  • Engineering of cells to sense and respond to physiological signals
  • Chronic viral infections
  • T cell response in tolerogenic environments

Selected Publications:

  1. Gaur P, Cebula M, Riehn M, Hillebrand U, Hauser H, Wirth D. Diet induced obesity has an influence on intrahepatic T cell responses. Metabolism. 2017; 69:171–6.
  2. Spencer S, Gugliotta A, Gödecke N, Hauser H, Wirth D. Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability. Journal of Genetics and Genomics. 2016; 43(8):503-11.
  3. Ochel, A., Cebula, M., Riehn, M., Hillebrand, U., Lipps, C., Schirmbeck, R., Hauser, H., Wirth, D. Effective intrahepatic CD8+ T-cell immune responses are induced by low but not high numbers of antigen-expressing hepatocytes. Cellular and Molecular Immunology. 2016; 13(6):805-15.
  4. Lipps, C., Badar, M., Butueva, M., Dubich, T., Singh, V. V., Rau, S., Weber, A., Kracht, M., Koster, M., May, T., Schulz, T. F., Hauser, H., Wirth, D. Proliferation status defines functional properties of endothelial cells. Cell Mol Life Sci. 2016.
  5. Rand U, Riedel J, Hillebrand U, Shin D, Willenberg S, Behme S, Klawonn, F., Koster, M., Hauser, H., Wirth, D. Single-cell analysis reveals heterogeneity in onset of transgene expression from synthetic tetracycline-dependent promoters. Biotechnol J. 2015; 10(2):323-31.
  6. Rand U, Hillebrand U, Sievers S, Willenberg S, Koster M, Hauser H, Wirth, D. Uncoupling of the dynamics of host-pathogen interaction uncovers new mechanisms of viral interferon antagonism at the single-cell level. Nucleic Acids Res. 2014; 42(13):e109.
  7. Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann, J., Schirmbeck, R., Hauser, H., Wirth, D. Strict control of transgene expression in a mouse model for sensitive biological applications based on RMCE compatible ES cells. Nucleic Acids Res. 2011; 39(1).
  8. May T, Butueva M, Bantner S, Markusic D, Seppen J, MacLeod RA, Weich, H., Hauser, H., Wirth, D. Synthetic gene regulation circuits for control of cell expansion. Tissue Eng Part A. 2010; 16(2):441-52.
  9. Gama-Norton L, Herrmann S, Schucht R, Coroadinha AS, Low R, Alves PM, Bartholomae, C. C., Schmidt, M., Baum, C., Schambach, A., Hauser, H., Wirth, D. Retroviral vector performance in defined chromosomal Loci of modular packaging cell lines. Hum Gene Ther. 2010;21(8):979-91.
  10. Nehlsen K, Herrmann S, Zauers J, Hauser H, Wirth D. Toxin-antitoxin based transgene expression in mammalian cells. Nucleic Acids Res. 2009;38(5):e32.


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