REBIRTH Members

Rinas, Ursula

Rinas, Ursula, Prof. Dr. rer. nat.

Work Group Leader

REBIRTH Unit Production and Purification of Recombinant Proteins, Institute for Technical Chemistry, Leibniz Universität Hannover


Biography / About

Date of Birth:May, 1957
Function:Researcher, group leader

Education:

1984Diploma in Chemistry

Academic appointments and Research posts:

1987PhD in Technical Chemistry at the University of Hannover
1988 - 1989Postdoc, Institute of Biophysics at the University of Regensburg
1989 - 1991Postdoc, California Institute of Technology, Pasadena, California, U.S.A
Since 1992Researcher, group leader, GBF National Research Center for Biotechnology, now Helmholtz Centre of Infection Research
Since 2012Professor (appl.) at the Institute of Technical Chemistry at the Leibniz University of Hannover

Major research interests:

  • Process development recombinant protein production with microbial expression systems (mainly E. coli but also A. niger and P. pastoris), e.g. protein based vaccines and cytokines for stem cell culture applications
  • Basic and applied research on in vivo and in vitro folding of proteins (e.g. inclusion bodies, folding kinetics, renaturation procedures for complex multimeric proteins)
  • Microbial cell physiology (e.g. stress responses, systems biotechnology)

Selected Publications:

  1. Rinas, U., Garcia-Fruitós, E., Corchero, J.L., Vázquez, E., Seras-Franzoso, J. and Villaverde, A. (2017) Bacterial inclusion bodies: discovering their better half. Trends Biochem. Sci., in press.
  2. Gieseler, G., Pepelanova, I., Meyer, A., Villain, L., Beutel, S., Rinas, U. and Scheper, T. (2016) Considerations on the flow configuration of membrane chromatography devices for the purification of human basic fibroblast growth factor from crude lysates. Eng. Life Sci., 16, 697-705.
  3. Hoepfner, J., Kleinsorge, M., Papp, O., Ackermann, M., Alfken, S., Rinas, U., Solodenko, W., Kirschning, A., Sgodda, M. and Cantz, T. (2016) Bi-phasic modulation of Wnt-signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Cell Biol. Int., 40, 534-548.
  4. Zahid, M., Lünsdorf, H. and Rinas, U. (2015) Assessing stability and assembly of the hepatitis B surface antigen into virus-like particles during down-stream processing. Vaccine, 33, 3739-3745.
  5. Li, Z., Nimtz, M. and Rinas, U. (2014) The metabolic potential of Escherichia coli BL21 in defined and rich medium. Microb. Cell Fact., 13, 45.
  6. Ricke-Hoch, M., Bultmann, I., Stapel, B., Condorelli, G., Rinas, U., Sliwa, K., Scherr, M. and Hilfiker-Kleiner, D. (2014) Opposing roles of Akt and STAT3 in protection of the maternal heart from peripartum stress. Cardiovasc. Res., 101, 587-596.
  7. Vallejo, L.F. and Rinas, U. (2013) Folding and dimerization kinetics of bone morphogenetic protein-2, a member of the transforming growth factor family. FEBS J., 280, 83-92.
  8. Vanz, A.L., Lünsdorf, H., Adnan, A., Nimtz, M., Gurramkonda, C., Khanna, N. and Rinas, U. (2012) Physiological response of Pichia pastoris 115 to methanol-induced high level production of the Hepatitis B surface antigen: catabolic adaptation, stress responses, and autophagic processes. Microb. Cell Fact., 11, 103.
  9. Li, Z., Kessler, W., van den Heuvel, J. and Rinas, U. (2011) Simple defined autoinduction medium for high-level recombinant protein production for T7-based Escherichia coli expression systems. Appl. Microbiol. Biotechnol., 91, 1203-1213.
  10. Bals, C., Schambach, A., Meyer, J., Scheper, T. and Rinas, U. (2011) Expression and purification of bioactive soluble murine stem cell factor from recombinant Escherichia coli using thioredoxin as fusion partner. J. Biotechnol., 152, 1-8.


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