REBIRTH Members

Manstein, Dietmar J.

Manstein, Dietmar J., Prof. Dr. rer. nat.

Institute for Biophysical Chemistry

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

manstein(at)bpc.mh-hannover.de

Biography / About

Date of Birth:April, 1955
Function:Professor and Director

Education:

1978 – 1983Diploma program in Biochemistry, Leibniz Universität Hannover (Thesis Supervisor: Prof. Dr. Jürg Rosenbusch, European Molecular Biology Laboratory)
1984 – 1986Natural Sciences Doctorat (Dr. rer. nat.), Ruprecht-Karls-University Heidelberg (Thesis Supervisor: Prof. Dr. Roger S. Goody, Max-Planck-Institute for Medical Research)
1999Post-doctoral lecturing qualification (Habilitation), Ruprecht-Karls-University Heidelberg (Supervisor: Prof. Dr. Felix Wieland)

Academic appointments and Research posts:

1983Predoctoral Research Assistant, European Molecular Biology Laboratory, Heidelberg
1984 – 1986Predoctoral Research Assistant, Max-Planck-Institute for Medical Research, Heidelberg
1986 – 1987Postdoctoral Research Assistant, Max-Planck-Institute for Medical Research, Heidelberg (Director: Prof. Kenneth C. Holmes, FRS)
1987 – 1990Postdoctoral Research Associate, Stanford University School of Medicine, USA (Postdoctoral advisor: Prof. J.A. Spudich)
1990 – 1996Group Leader, National Institute for Medical Research, London, UK
1996 – 2002Group Leader (C3), Max-Planck-Institute for Medical Research, Heidelberg
Since 2002Full (C4) Professor and Director at Medical School Hannover (MHH)

Other professional activities:

Since 1992Executive Editor Journal of Muscle Research and Cell Motility
2006 – 2012Speaker, DFG-Research Unit FOR629 “Molecular Mechanisms of Cell Motility”
Since 2008Editor FEBS Letters
2008 – 2011Scientific delegate on behalf of the DFG, ERA-Instruments Scientific Advisory Board (European Research Infrastructures Working Group)
2008 – 2014Representative of the German Structural Biology community, German Committee for Synchrotron Research (KFS)
2009 – 2013Representative for the State of Lower-Saxony on the Task Force for the Establishment of the Centre for Structural Systems Biology (CSSB) at DESY, Hamburg
Since 2011Cofounding Editor FEBS OpenBio
Since 2013Member of the CSSB Board of Directors
Since 2014Member of the Academic Advisory Board, Hannover School for Biomolecular Drug Research (HSBDR), Leibniz University Hannover

Awards and Prizes:

1985DFG Fellowship for research at the Department of Biological Chemistry, University of Michigan Medical School; Ann Arbor, U.S.A.
1987 – 1989Longterm DFG Fellowship for research in the Departments of Cell Biology and Developmental Biology, Stanford University School of Medicine, Stanford, U.S.A.
2002Wellcome Trust University Award combined with the appointment to a full professorship, School of Biosciences, University of Kent, Canterbury, Kent, and U.K. (not accepted)
2002Call, Chair of Physiological Chemistry (primo et unico loco), Ruhr University Bochum (not accepted)

Major research interests:

Elucidation of the molecular mechanisms underlying motile events is of significance with respect to a wide range of health related issues, such as neurodegeneration, heart failure, skeletal muscle myopathies, cell-mediated immune response, wound healing, and the invasion of healthy tissue by malignant tumor cells. The following proteins and topics are central to our work program: actin, dynamin, myosin, tropomyosin, intracellular pathogen sensors; protein structure, dynamics, reaction mechanisms, and allostery; cell motility, cytoskeletal dynamics; pharmacological chaperone-based approaches to treat muscle disorders and cytoskeletal protein-linked diseases; small-molecule based approaches to prevent and treat sepsis.

Selected Publications:

  1. von der Ecken J, Heissler SM, Pathan-Chhatbar S, Manstein DJ, Raunser S. Cryo-EM structure of a human cytoplasmic actomyosin complex at near-atomic resolution. Nature. 2016 Jun 30; 534(7609):724-8. PubMed PMID: 27324845.
  2. Manstein DJ, Mulvihill DP. Tropomyosin-Mediated Regulation of Cytoplasmic Myosins. Traffic. 2016 Aug;17(8): 872-7. PubMed PMID: 27060364.
  3. Hundt N, Steffen W, Pathan-Chhatbar S, Taft MH, Manstein DJ. Load-dependent modulation of non-muscle myosin-2A function by tropomyosin 4.2. Sci Rep. 2016 Feb 05;6:20554. PubMed PMID: 26847712. PMCID: PMC4742800.
  4. von der Ecken J, Müller M, Lehman W, Manstein DJ, Penczek PA, Raunser S. Structure of the F-actin-tropomyosin complex. Nature. 2015 Mar 5; 519(7541):114-7. PubMed PMID: 25470062. PMCID: PMC4477711.
  5. Reubold TF, Faelber K, Plattner N, Posor Y, Ketel K, Curth U, Schlegel J, Anand R, Manstein DJ, Noe F, Haucke V, Daumke O, Eschenburg S. Crystal structure of the dynamin tetramer. Nature. 2015 Sep 17;525(7569):404-8. PubMed PMID: 26302298.
  6. Radke MB, Taft MH, Stapel B, Hilfiker-Kleiner D, Preller M, Manstein DJ. Small molecule-mediated refolding and activation of myosin motor function. Elife. 2014 Feb 11; 3:e01603. PubMed PMID: 24520162. PMCID: PMC3920478.
  7. Taft MH, Behrmann E, Munske-Weidemann LC, Thiel C, Raunser S, Manstein DJ. Functional characterization of human myosin-18A and its interaction with F-actin and GOLPH3. J Biol Chem. 2013 Oct 18;288(42):30029-41. PubMed PMID: 23990465. PMCID: PMC3798472. Epub 2013/08/31. eng.
  8. Behrmann E, Müller M, Penczek PA, Mannherz HG, Manstein DJ, Raunser S. Structure of the rigor actin-tropomyosin-myosin complex. Cell. 2012 2012;150(2): 327-38. PubMed PMID: WOS:000306595700012.
  9. Rai A, Nöthe H, Tzvetkov N, Korenbaum E, Manstein DJ. Dictyostelium dynamin B modulates cytoskeletal structures and membranous organelles. Cell Mol Life Sci. 2011 Aug;68(16):2751-67. PubMed PMID: 21086149. PMCID: PMC3142549. Epub 2010/11/19. eng.
  10. Fedorov R, Böhl M, Tsiavaliaris G, Hartmann FK, Taft MH, Baruch P, Brenner B, Martin R, Knölker H-J, Gutzeit HO, Manstein DJ. The mechanism of pentabromopseudilin inhibition of myosin motor activity. Nat Struct Mol Biol. 2009 Jan;16(1): 80-8. PubMed PMID: 19122661. Epub 2009/01/06. eng.


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