REBIRTH Members

Hansen, Gesine

Hansen, Gesine , Prof. Dr. med.

Full (W3) Professor of Pediatrics and Chair of the Department


Biosketch:

G. Hansen (*1965) is W3 professor and head of the Department of Pediatric Pneumology, Allergology and Neonatology at Hannover Medical School (MHH), trained in Germany, U.K. (London) and U.S. (Stanford). She has a long-standing history of experimental/clinical research in immunology and lung diseases (DFG, BMBF), was speaker of the collaborative research centre “Immune reaction of the lung in allergy and infection” (CRC/SFB587, DFG) and PI in several interdisciplinary consortia addressing immune mechanisms and cell therapies for rare lung diseases (BMBF). She is member of the German National Academy of Sciences Leopoldina, board member of the German Center for Lung Research (DZL, Hannover site BREATH), and was long-term president of the International Society of Pediatric Pneumology.. Her research focuses on cell therapy for rare lung diseases, immune mechanisms of early environmental priming, infection and allergies.

Biography / About

Date of Birth:October, 1965
Function:Full (W3) Professor of Pediatrics and Chair of the Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH)

Education:

1985 - 1992Medical School, Bochum University, Charing Cross & Westminster Medical School, London, UK
1992Medical Doctorate (Dr. med.), Department of Microbiology and Virology, Bochum University, Germany
1992License as MD
1993 - 1997Resident and Fellow, Department of Pediatrics, Düsseldorf University, Germany
1997 - 1999Research Associate, Immunology & Transplantation Biology, Stanford University, CA, USA
1999 - 2003Fellow and Senior Consultant (Oberärztin), Pediatrics, Halle University, Germany
2001Post-doctoral lecturing qualification (Habilitation) and venia legendi in Pediatrics, Halle University

Academic appointments and Research posts:

2001 - 2006Head Research Group ‘Immune regulatory mechanisms in allergic asthma’, Federal Ministry of Education and Research (BMBF)
2003 - 2005Professor of Pediatrics (C3 professorship) and Vice Chair Department of Pediatrics, Halle University
Since 2006Professor of Pediatrics (W3 professorship), Chair Center of Pediatrics, MHH
2009 - 2014Spokesperson, DFG Collaborative Research Center ‘SFB 587: Immune reactions of the Lung in Infection and Allergies’
Since 2013Member, management board, German Center for Lung Research (DZL) - BREATH (BMBF)

Other professional activities:

Since 2006Commission for Drugs in Children and Adolescents, Member, Federal Ministry of Health
2004 - 2008Executive Committee Member, International Society of Pediatric Pneumology
2008 - 2015President, International Society of Pediatric Pneumology (GPP)
2008 - 2015Executive Committee Member, Society of Pediatric Allergology
2008 - 2013Advisory Board Member, Program of Medical Genome Research (BMBF)
2016 - 2020Member, Review Board Commission, Germany Research Foundation (DFG)

Awards and Prizes:

2000International Young Investigator Award, Munich, Germany
2001Johannes Wenner Award, Int. Society of Pediatric Pneumology, Bern, Switzerland
2001Arthur Schlossmann Award, Society of Pediatrics, Germany
2002Wilhelm-Roux-Research Award, Halle University
2002Adalbert-Czerny-Award, German Society of Pediatrics, Leipzig, Germany
2003International Pharmacia Allergy Research Award, Vancouver, Canada
2007Karl Hansen Award, German Society for Allergy and Clinical Immunology, Lübeck, Germany
2013Eva Luise Köhler Research Award for Rare Diseases, Berlin, Germany
2013Member, Leopoldina, National Academy of Sciences

Major research interests:

  • Immune regulation in allergy and asthma
  • Mucosal immunology
  • Perinatal immune priming
  • Cell therapy in rare pulmonary diseases
  • Lung infection, founder and head RSV bronchiolitis cohort (RIVA) and pediatric community acquired pneumonia network (pedCapNetz)

Selected Publications:

  1. Habener A, Behrendt AK, Skuljec J, Jirmo, AC, Meyer-Bahlburg A, Hansen G. B cell subsets are modulated durfing B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model. J Immunol. 2016. DOI: 10.1002/eji.201646518.
  2. Happle C, Lachmann N, Skuljec J, Wetzke M, Ackermann,M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Science Transl Med. 2014. 6: 250ra113. DOI: 10.1126/scitranslmed.3009750.
  3. Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G*, Moritz T* (*equal contribution). Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis. Am J Respir Crit Care Med. 2014. 189: 167-182. DOI: 10.1164/rccm.201306-1012OC.
  4. Hennig C, Ilginus C, Boztug K, Skokowa J, Marodi L, Szaflarska A, Sass M, Pignata C, Kilic SS, Caragol I, Baumann U, Klein C, Welte K, Hansen G. High-content cytometry and transcriptomic biomarker profiling of human B-cell activation. J Allergy Clin Immunol. 2014. 133: 172-180 e171-110. DOI: 10.1016/j.jaci.2013.06.047.
  5. Dijkstra D, Hennig C, Witte T, Hansen G. Basophils from humans with systemic lupus erythematosus do not express MHC-II. Nature Medicine. 2012. 18: 488-489; 489-490. DOI: 10.1038/nm.2663
  6. Polte T, Hennig C, Hansen G. Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma. J Allergy Clin Immunol. 2008. 122: 1022-1030 e1025. DOI: 10.1016/j.jaci.2008.09.014.
  7. Polte T, Foell J, Werner C, Hoymann HG, Braun A, Burdach S, Mittler RS, Hansen G. CD137-mediated immunotherapy for allergic asthma. J Clin Invest. 2006. 116: 1025-1036. DOI: 10.1172/JCI23792
  8. Polte T, Behrendt AK, Hansen G. Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol. 2006. 118: 942-948. DOI: 10.1016/j.jaci.2006.07.014
  9. Hansen G, McIntire JJ, Yeung VP, Berry G, Thorbecke GJ, Chen L, DeKruyff RH, Umetsu DT. CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation. J Clin Invest. 2000. 105: 61-70. DOI: 10.1172/JCI7589
  10. Hansen G, Berry G, DeKruyff RH, Umetsu DT. Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999. 103: 175-183. DOI: 10.1172/JCI5155


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