REBIRTH Members

Duezel, Emrah

Duezel, Emrah , Prof. Dr. med.

Full (W3) Professor and Head of the Institute


Biosketch:

E. Düzel (*1968), MD/PhD, is director of the Institute of Cognitive Neurology and Dementia Research at OvGU Magdeburg, Speaker of the German Center for Neurodegenerative Diseases in Magdeburg (Helmholtz Society), and Professor (part-time) at the Cognitive Neuroscience of the University College London (UCL). He investigates the functional circuitry of human memory, its dysfunction in aging and neurodegenerative diseases and its scope for plasticity and pharmacological enhancement. His research has laid the groundwork for mapping and decoding the progressive loss of memory representations with advancing disease pathology in Alzheimer’s Disease and for understanding the impact of dysfunctional dopaminergic and noradrenergic neuromodulation. His group showed that the hippocampus of older adults maintains a potential for vascular plasticity after aerobic exercise.

Biography / About

Date of Birth:June, 1968
Function:Full (W3) Professor and Head of the Institute of Cognitive Neurology and Dementia Research, OVGU Magdeburg / Speaker, DZNE site Magdeburg / Professor of Cognitive Neuroscience, UCL and Lab Group Leader ‘Clinical Neurophysiology & Memory’, Institute of Cognitive Neuroscience, UCL /

Education:

1986 - 1992Studies in medicine at the University Münster, Germany and the University of Bonn, Germany
1992Graduation from Medical School, Bonn, Germany
1993Medical Doctor, University of Bonn, Germany
2001Consultant Neurologist, OVGU Magdeburg
2003Post-doctoral lecturing qualification (Habilitation), OVGU Magdeburg

Academic appointments and Research posts:

1996Postdoctoral Research Fellow, University of California, Davis, CA, USA
1996 - 1997Rotman Research Institute (Prof. E. Tulving), University of Toronto, Canada
2004 - 2005C3 Professor of Cognitive Neurology, OVGU Magdeburg
2005 - 2006Clinical Reader, UCL, UK
Since 12/2006Professor of Cognitive Neuroscience, UCL, UK (since 11/2008 part-time 25%)
2006 - 2009Head of DFG clinical research unit ‘KFO 163: Cognitive Control of Memory Functions: From Basic Research to Clinical Practice’
Since 01/2008Professor of Cognitive Neurology and Dementia Research, OVGU Magdeburg
Since 07/2011Speaker of the German Center for Neurodegenerative Diseases (DZNE), Magdeburg

Other professional activities:

1993 - 1995MD at the Department of Epileptology, University of Bonn
1997 - 1998MD at the Department of Psychiatry, OVGU Magdeburg
1998 - 2001MD at the Department of Neurology II, OVGU University Magdeburg
2001 - 2005Consultant Neurologist at the Department of Neurology II, OVGU Magdeburg
2005 - 2008Honorary Consultant Neurologist, Department of Clinical and Experimental Epileptology, National Hospital for Neurology and Neurosurgery London, UK
Since 2015Coordinator German National Neuroimaging Network
Since 2016Coordinator ‘European Ultrahigh-Field Imaging Network for Neurodegenerative Diseases (EUFIND)’, Medical Research Council, UK

Awards and Prizes:

1986 - 1992German Academic Scholarship Foundation (‘Studienstiftung des deutschen Volkes’) awardee
2012Otto von Guericke Medal of Saxony-Anhalt, Germany
2015Chancellors Award Lecture, LSU New Orleans
2015 - 2018Google Research Award (unrestricted, 100.000 € annual)

Major research interests:

  • Learning
  • Memory
  • Reward
  • Dopamine
  • Novelty
  • Aging
  • Plasticity

Selected Publications:

  1. Moon HY, Becke A, Berron D, Becker B, Sah N, Benoni G, Janke E, Lubejko ST, Greig NH, Mattison JA, Duzel E, van Praag H. Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function. Cell metabolism. 2016;24(2):332-40. Epub 2016/06/28.
  2. Duzel E, van Praag H, Sendtner M. Can Physical Exercise in Old Age Improve Memory and Hippocampal Function? Brain : a journal of neurology. 2016;139(Pt 3):662-73. Epub 2016/02/26.
  3. Betts MJ, Acosta-Cabronero J, Cardenas-Blanco A, Nestor PJ, Duzel E. High-Resolution Characterisation of the Aging Brain Using Simultaneous Quantitative Susceptibility Mapping (Qsm) and R2* Measurements at 7t. NeuroImage. 2016;138:43-63. Epub 2016/05/18.
  4. Berron D, Schutze H, Maass A, Cardenas-Blanco A, Kuijf HJ, Kumaran D, Duzel E. Strong Evidence for Pattern Separation in Human Dentate Gyrus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2016;36(29):7569-79. Epub 2016/07/23.
  5. Wagenbreth C, Zaehle T, Galazky I, Voges J, Guitart-Masip M, Heinze HJ, Duzel E. Deep Brain Stimulation of the Subthalamic Nucleus Modulates Reward Processing and Action Selection in Parkinson Patients. Journal of neurology. 2015;262(6):1541-7. Epub 2015/05/02.
  6. Maass A, Duzel S, Goerke M, Becke A, Sobieray U, Neumann K, Lovden M, Lindenberger U, Backman L, Braun-Dullaeus R, Ahrens D, Heinze HJ, Muller NG, Duzel E. Vascular Hippocampal Plasticity after Aerobic Exercise in Older Adults. Molecular psychiatry. 2015;20(5):585-93. Epub 2014/10/15.
  7. Maass A, Berron D, Libby LA, Ranganath C, Duzel E. Functional Subregions of the Human Entorhinal Cortex. eLife. 2015;4. Epub 2015/06/09.
  8. Maass A, Schutze H, Speck O, Yonelinas A, Tempelmann C, Heinze HJ, Berron D, Cardenas-Blanco A, Brodersen KH, Stephan KE, Duzel E. Laminar Activity in the Hippocampus and Entorhinal Cortex Related to Novelty and Episodic Encoding. Nature communications. 2014;5:5547. Epub 2014/11/27.
  9. Bunzeck N, Guitart-Masip M, Dolan RJ, Duzel E. Pharmacological Dissociation of Novelty Responses in the Human Brain. Cerebral cortex. 2014;24(5):1351-60. Epub 2013/01/12.
  10. Duzel E, Guitart-Masip M. Not So Uncertain at Last: Locus Coeruleus and Decision Making. Neuron. 2013;79(1):9-11. Epub 2013/07/16.


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