REBIRTH Members

Bakker, Hans

Bakker, Hans, Prof. Dr.

Institute for Cellular Chemistry

Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hannover

Bakker.Hans(at)mh-hannover.de

Biography / About

Date of Birth:December, 1963
Function:Group Leader

Education:

1983 - 1989Study biology, Utrecht University, The Netherlands
1990 - 1991(Alternative military service) Institute for Molecular Biology and Medical Biotechnology, University of Utrecht, The Netherlands
1991 - 1996Doctoral studies, VU University, Amsterdam, The Netherlands. Promotor: Prof. Dr. D.H.van den Eijnden and Dr. I.M. van Die

Academic appointments and Research posts:

1996 - 1997Post-doctoral-researcher, Neurobiology, ETH-Zürich, Switzerland
1997 - 2001Research Scientist Department of Molecular Biology, Plant Research International, Wageningen, The Netherlands
Since 2001Group Leader, MHH, Institute of Clinical Biochemisty, Hannover, Germany
2007 - 2012Leader of the Research Group “Stem Cell Glycans” in the frame of the DFG-cluster of excellence REBIRTH

Other professional activities:

2005Co-organizer of the 16th Joint Meeting of Glycobiology, Hannover, Germany
2012Co-organizer of the international conference on glycosyltranferases, Glyco T 2012, Hannover, Germany

Major research interests:

  • Glycosylation of EGF repeats
  • C-Mannosylation of thrombospondin repeats
  • Xylose metabolism
  • Glycolipid specificity of glycosyltransferase

Selected Publications:

  1. Shcherbakova, A., Tiemann, B., Buettner, F.F., & Bakker, H. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Proc. Natl. Acad. Sci. U.S.A. 114, 2574-2579 (2017).
  2. Yu, H., Takeuchi, M., LeBarron, J., Kantharia, J., London, E., Bakker, H., Haltiwanger, R. S., Li, H. & Takeuchi, H. Notch-modifying xylosyltransferase structures support an SNi-like retaining mechanism. Nat. Chem. Biol. 11, 847-54.(2015).
  3. Buettner, F.F., Ashikov, A., Tiemann, B., Lehle, L. & Bakker, H. C. elegans DPY-19 is a C-mannosyltransferase glycosylating thrombospondin repeats. Mol. Cell 50, 295-302 (2013).
  4. Ashikov, A., Buettner, F.F., Tiemann, B., Gerardy-Schahn, R. & Bakker, H. LARGE2 generates the same xylose- and glucuronic acid-containing glycan structures as LARGE. Glycobiology 23, 303-309 (2013).
  5. Sethi, M.K., Buettner, F.F., Ashikov, A., Krylov, V.B., Takeuchi, H., Nifantiev, N.E., Haltiwanger, R.S., Gerardy-Schahn, R. & Bakker, H. Molecular cloning of a xylosyltransferase that transfers the second xylose to O-glucosylated epidermal growth factor repeats of notch. J. Biol. Chem. 287, 2739-2748 (2012).
  6. Kraft, B., Johswich, A., Kauczor, G., Scharenberg, M., Gerardy-Schahn, R. & Bakker, H. "Add-on" domains of drosophila β1,4-N- acetylgalactosaminyltransferase B in the stem region and its pilot protein. Cell. Mol. Life Sc. 68, 4091-4100 (2011).
  7. Sethi, M.K., Buettner, F.F., Krylov, V. B., Takeuchi, H., Nifantiev, N.E., Haltiwanger, R.S., Gerardy-Schahn, R. & Bakker, H. Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. J. Biol. Chem. 285, 1582-1586 (2010).
  8. Bakker, H., Oka, T., Ashikov, A., Yadav, A., Berger, M., Rana, N.A., Bai, X., Jigami, Y., Haltiwanger, R.S., Esko, J.D. & Gerardy-Schahn, R. Functional UDP-xylose transport across the endoplasmic reticulum/golgi membrane in a chinese hamster ovary cell mutant defective in UDP-xylose synthase. J. Biol. Chem. 284, 2576-2583 (2009).
  9. Johswich, A., Kraft, B., Wuhrer, M., Berger, M., Deelder, A.M., Hokke, C.H., Gerardy-Schahn, R. & Bakker, H. Golgi targeting of Drosophila melanogaster β4GalNAcTB requires a DHHC protein family - related protein as a pilot. J. Cell Biol. 184, 173-183 (2009).
  10. Bakker, H., Rouwendal, G.J., Karnoup, A.S., Florack, D.E., Stoopen, G.M., Helsper, J.P., Van Ree, R., Van Die, I. & Bosch, D. An antibody produced in tobacco expressing a hybrid β-1,4- galactosyltransferase is essentially devoid of plant carbohydrate epitopes. Proc. Natl. Acad. Sci. U.S.A. 103, 7577-7582 (2006).


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