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15 March 2019Neugierde fördern, Fakten vermitteln und Fragen beantworten: Der Exzellenzcluster REBIRTH lädt im ...
REBIRTH Members
Schöler, Hans, Prof. Dr. rer. nat.
Max Planck Institute for Molecular Biomedicine, Cell and Developmental Biology
Röntgenstraße 20
48149 Münster
Schoeler(at)mpi-muenster.mpg.de
Biography / About
| Date of Birth: | January, 1953 |
| Function: | Managing Director |
Education:
| 12/1982 | Diploma Biology, Heidelberg University, Heidelberg, Germany |
| 01/1985 | PhD, Molecular Biology, Heidelberg University, Heidelberg, Germany |
| 05/1994 | Post-doctoral lecturing qualification (Habiliation) in Molecular Biology, Heidelberg University, Heidelberg, Germany |
Present Academic appointments and Research posts:
- Managing Director of the Max Planck Institute for Molecular Biomedicine, Münster, Germany
- Full Professor of the Medical Faculty of the “Westfälische Wilhelms-Universität”, Münster, Germany
- Adjunct (APL) Professor of the Medical School Hanover (MHH), Hanover, Germany
- Adjunct (APL) Professor of Biochemistry, University of Pennsylvania, Center for Animal Transgenesis and Germ Cell Research, Philadelphia, USA
- Distinguished Professor at the UNIST, Ulsan, South Korea
- Distinguished Professor at Konkuk University, Seoul, South Korea
Previous Academic appointments and Research posts:
| 1984 - 1986 | Staff Scientist, Centre for Molecular Biology Heidelberg (ZMBH) Heidelberg University, Germany |
| 1986 - 1988 | Head Research Group, Boehringer Mannheim GmbH, Research Center, Tutzing, Germany |
| 1988 - 1991 | Staff Scientist, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany |
| 1991 - 1999 | Head Research Group, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany |
| 1999 - 2004 | Professor of Reproductive Physiology, School of Veterinary Medicine and Director of the Center for Animal Transgenesis and Germ Cell Research at the University of Pennsylvania, Philadelphia, USA |
| 2000 - 2004 | The Marion Dilley and David George Jones Chair in Reproduction Medicine |
Awards and Prizes:
| 2008 | Robert Koch Prize (with Shinya Yamanaka and Irving Weissman) |
| 2010 | Foundation of the “Hans Schöler Stem Cell Research Center” at Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea |
| 2011 | Kazemi Prize awarded from Royan Institute, Teheran, Iran |
| 2011 | Berlin Lecture on Molecular Medicine and Max Delbrück Medal awarded by the Max Delbrück Center, Berlin, Germany |
| 2011 | President’s Lecture at Konkuk University, School of Medicine, Seoul, South Korea |
| 2015 | European Research Council (ERC) Advanced Grant |
Major research interests:
- Molecular biology of the mammalian germline (pluripotent cells and germ cells)
- In vitro and in vivo reprogramming
- Disease modelling and drug screening
Selected Publications:
- Kim, J. B., Sebastiano, V., Wu, G., Arauzo-Bravo, M. J., Sasse, P., Gentile, L., Ko, K., Ruau, D., Ehrich, M., van den Boom, D., Meyer, J., Hubner, K., Bernemann, C., Ortmeier, C., Zenke, M., Fleischmann, B. K., Zaehres, H., Schöler, H. R., Oct4-induced pluripotency in adult neural stem cells. Cell 3:411, 2009.
- Kim, J. B., Zaehres, H., Wu, G., Gentile, L., Ko, K., Sebastiano, V., Arauzo-Bravo, M. J., Ruau, D., Han, D. W., Zenke, M., Schöler, H. R., Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 454:646, 2008
- Do, J. T., Schöler, H. R., Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 22:941, 2004.
- Kehler, J., Tolkunova, E., Koschorz, B., Pesce, M., Gentile, L., Boiani, M., Lomeli, H., Nagy, A., McLaughlin, K. J., Schöler, H. R.,, Tomilin, A. Oct4 is required for primordial germ cell survival. EMBO Rep 5:1078, 2004
- Hübner, K., Fuhrmann, G., Christenson, L. K., Kehler, J., Reinbold, R., De La Fuente, R., Wood, J., Strauss, J. F., Boiani, M., Schöler, H. R., Derivation of oocytes from mouse embryonic stem cells. Science 300:1251, 2003.
- Remenyi, A., Lins, K., Nissen, L. J., Reinbold, R., Schöler, H. R.,, Wilmanns, M. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes Dev. 17:2048, 2003.
- Boiani, M., Eckardt, S., Schöler, H. R.,, McLaughlin, K. J. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev 16:1209, 2002.
- Remenyi, A., Tomilin, A., Pohl, E., Lins, K., Philippsen, A., Reinbold, R., Schöler, H. R.,, Wilmanns, M. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. Mol Cell 8:569, 2001.
- Fuhrmann, G., Chung, A. C. K., Jackson, K. J., Hummelke, G., Baniahmad, A., Sutter, J., Sylvester, I., Schöler, H. R.,, Cooney, A. J. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell 1:377, 2001.
- Tomilin, A., Remenyi, A., Lins, K., Bak, H., Leidel, S., Vriend, G., Wilmanns, M., Schöler, H. R., Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Cell 103:853, 2000.
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