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REBIRTH Members

Schöler, Hans, Prof. Dr. rer. nat.

Max Planck Institute for Molecular Biomedicine, Cell and Developmental Biology
Röntgenstraße 20
48149 Münster

Schoeler(at)mpi-muenster.mpg.de

Biography / About

Date of Birth:	January, 1953
Function:	Managing Director

Education:

12/1982	Diploma Biology, Heidelberg University, Heidelberg, Germany
01/1985	PhD, Molecular Biology, Heidelberg University, Heidelberg, Germany
05/1994	Post-doctoral lecturing qualification (Habiliation) in Molecular Biology, Heidelberg University, Heidelberg, Germany

Present Academic appointments and Research posts:

Managing Director of the Max Planck Institute for Molecular Biomedicine, Münster, Germany
Full Professor of the Medical Faculty of the “Westfälische Wilhelms-Universität”, Münster, Germany
Adjunct (APL) Professor of the Medical School Hanover (MHH), Hanover, Germany
Adjunct (APL) Professor of Biochemistry, University of Pennsylvania, Center for Animal Transgenesis and Germ Cell Research, Philadelphia, USA
Distinguished Professor at the UNIST, Ulsan, South Korea
Distinguished Professor at Konkuk University, Seoul, South Korea

Previous Academic appointments and Research posts:

1984 - 1986	Staff Scientist, Centre for Molecular Biology Heidelberg (ZMBH) Heidelberg University, Germany
1986 - 1988	Head Research Group, Boehringer Mannheim GmbH, Research Center, Tutzing, Germany
1988 - 1991	Staff Scientist, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany
1991 - 1999	Head Research Group, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
1999 - 2004	Professor of Reproductive Physiology, School of Veterinary Medicine and Director of the Center for Animal Transgenesis and Germ Cell Research at the University of Pennsylvania, Philadelphia, USA
2000 - 2004	The Marion Dilley and David George Jones Chair in Reproduction Medicine

Awards and Prizes:

2008	Robert Koch Prize (with Shinya Yamanaka and Irving Weissman)
2010	Foundation of the “Hans Schöler Stem Cell Research Center” at Ulsan National Institute of Science and Technology (UNIST), Ulsan, South Korea
2011	Kazemi Prize awarded from Royan Institute, Teheran, Iran
2011	Berlin Lecture on Molecular Medicine and Max Delbrück Medal awarded by the Max Delbrück Center, Berlin, Germany
2011	President’s Lecture at Konkuk University, School of Medicine, Seoul, South Korea
2015	European Research Council (ERC) Advanced Grant

Major research interests:

Molecular biology of the mammalian germline (pluripotent cells and germ cells)
In vitro and in vivo reprogramming
Disease modelling and drug screening

Selected Publications:

Kim, J. B., Sebastiano, V., Wu, G., Arauzo-Bravo, M. J., Sasse, P., Gentile, L., Ko, K., Ruau, D., Ehrich, M., van den Boom, D., Meyer, J., Hubner, K., Bernemann, C., Ortmeier, C., Zenke, M., Fleischmann, B. K., Zaehres, H., Schöler, H. R., Oct4-induced pluripotency in adult neural stem cells. Cell 3:411, 2009.
Kim, J. B., Zaehres, H., Wu, G., Gentile, L., Ko, K., Sebastiano, V., Arauzo-Bravo, M. J., Ruau, D., Han, D. W., Zenke, M., Schöler, H. R., Pluripotent stem cells induced from adult neural stem cells by reprogramming with two factors. Nature 454:646, 2008
Do, J. T., Schöler, H. R., Nuclei of embryonic stem cells reprogram somatic cells. Stem Cells 22:941, 2004.
Kehler, J., Tolkunova, E., Koschorz, B., Pesce, M., Gentile, L., Boiani, M., Lomeli, H., Nagy, A., McLaughlin, K. J., Schöler, H. R.,, Tomilin, A. Oct4 is required for primordial germ cell survival. EMBO Rep 5:1078, 2004
Hübner, K., Fuhrmann, G., Christenson, L. K., Kehler, J., Reinbold, R., De La Fuente, R., Wood, J., Strauss, J. F., Boiani, M., Schöler, H. R., Derivation of oocytes from mouse embryonic stem cells. Science 300:1251, 2003.
Remenyi, A., Lins, K., Nissen, L. J., Reinbold, R., Schöler, H. R.,, Wilmanns, M. Crystal structure of a POU/HMG/DNA ternary complex suggests differential assembly of Oct4 and Sox2 on two enhancers. Genes Dev. 17:2048, 2003.
Boiani, M., Eckardt, S., Schöler, H. R.,, McLaughlin, K. J. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev 16:1209, 2002.
Remenyi, A., Tomilin, A., Pohl, E., Lins, K., Philippsen, A., Reinbold, R., Schöler, H. R.,, Wilmanns, M. Differential dimer activities of the transcription factor Oct-1 by DNA-induced interface swapping. Mol Cell 8:569, 2001.
Fuhrmann, G., Chung, A. C. K., Jackson, K. J., Hummelke, G., Baniahmad, A., Sutter, J., Sylvester, I., Schöler, H. R.,, Cooney, A. J. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev Cell 1:377, 2001.
Tomilin, A., Remenyi, A., Lins, K., Bak, H., Leidel, S., Vriend, G., Wilmanns, M., Schöler, H. R., Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration. Cell 103:853, 2000.

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