Work Group Leaders

Mühlfeld, Christian

Mühlfeld, Christian, Prof. Dr. med.

Work Group Leader

REBIRTH Unit Quantitative Microscopy in Regeneration, Institut für Funktionelle und Angewandte Anatomie, MHH

Biography / About

Date of Birth:February, 1976
Function:Associate (W2) Professor of Anatomy


1997 - 2003University studies (Human Medicine) at the Georg-August-University, Göttingen (GAU), Germany
2003Doctoral thesis (“magna cum laude”) at GAU, Göttingen, Germany
2009“Habilitation” and Venia legendi for the speciality “Anatomy and Cell Biology” at the Justus-Liebig-University, Gießen, Germany

Academic appointments and Research posts:

2003 - 2006Postdoctoral Fellow, Institute of Anatomy, University of Göttingen, Göttingen, Germany
2005Guest scientist at the Stereology and Electron Microscopy Research Laboratory, University of Aarhus, Aarhus, Denmark
2006 - 2008Postdoctoral Fellow, Institute of Anatomy, University of Bern, Bern, Switzerland
2008 - 2010Postdoctoral Fellow, Institute of Anatomy and Cell Biology, University of Gießen, Gießen, Germany
2010 - 2011Head of Electron Microscopy Division, Institute of Anatomy and Cell Biology, Justus-Liebig-University, Gießen, Germany
Since 2011Professor of Anatomy, Institute of Functional and Applied Anatomy, MHH, Hannover, Germany

Other professional activities:

  • Reviewer for various international biomedical journals;
  • Editorial board member of American Journal of Physiology Lung Cellular and Molecular Physiology, Annals of Anatomy;
  • Faculty member of the International Stereology Course, Institute of Anatomy, University of Bern, Switzerland

Awards and Prizes:

2001 - 2003Scholarship of the German Scholarship Foundation (“Studienstiftung des Deutschen Volkes”)
2004Travel Award of the Federation of European Biochemical Societies (FEBS)
2007International Trainee Travel Award of the American Thorastic Society
2008 - 2012Associate Faculty Member of Faculty of 1000
2012 - 2017Full Faculty Member of Faculty of 1000

Major research interests:

  • Cardiac and pulmonary remodelling
  • Advanced (electron) microscopy
  • Stereology

Selected Publications:

  1. Grothausmann R, Knudsen L, Ochs M, Mühlfeld C. Digital reconstructions of histological serial sections demonstrated on the alveolar capillary network of the lung. Am J Physiol Lung Cell Mol. 2017. 312: L243-L257.
  2. Kling K, Lopez-Rodriguez E, Pfarrer C, Mühlfeld C, Brandenberger C. Aging exacerbates acute lung injury induced changes of the air-blood barrier, lung function and inflammation in the mouse. Am J Physiol Lung Cell Mol Physiol. 2017. 312: L1-L12.
  3. Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Büttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Mühlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F.Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016. 22: 1428-1438.
  4. Willführ A, Brandenberger C, Piatkowski T, Grothausmann R, Nyengaard JR, Ochs M, Mühlfeld C. A new method to evaluate the alveolar capillary network based on the Euler-Poincaré characteristic. Am J Physiol Lung Cell Mol Physiol. 2015. 309: L1286-L1293.
  5. Tahedl D, Wirkes A, Tschanz SA, Ochs M, Mühlfeld C. How common is the lipid-containing interstitial cell in the mammalian lung? Am J Physiol Lung Cell Mol Physiol. 2014. 307: L386-L394.
  6. Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Mühlfeld C, Engel FB. Adhesion G protein-coupled receptor GPR126 function is organ-specific. Proc Natl Acad Sci USA. 2013. 110 (42): 16898-16903.
  7. Patra C, Talukdar S, Novoyatleva T, Velagala SR, Mühlfeld C, Kundu SC, Engel FB. Silk fibroin from Antheraea mylitta: a novel biomaterial for cardiac tissue engineering. Biomaterials. 2012. 33 (9): 2673-2680.
  8. Wirkes A, Jung K, Ochs M, Mühlfeld C. Allometry of the mammalian intracellular pulmonary surfactant system. J Appl Physiol. 2010. 109: 1662-1669.
  9. Mühlfeld C, Becker L, Bussinger C, Vollroth M, Nagib R, Schaefer IM, Knudsen L, Richter J, Madershahian N, Wahlers T, Wittwer T, Ochs M. Effect of exogenous surfactant on endogenous surfactant pools in rat lung ischemia/reperfusion injury. J Heart Lung Transplant. 2010. 29: 327-334.
  10. Mühlfeld C, Schaefer IM, Becker L, Bussinger C, Vollroth M, Bosch A, Nagib R, Madershahian N, Richter J, Wahlers T, Wittwer T, Ochs M. Preischaemic exogenous surfactant reduces pulmonary injury in rat ischaemia/reperfusion. Eur Respir J. 2009. 33 (3): 625-633. Joined first authorship

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