By Unit

Publications

Please find below the REBIRTH-related publications of each Unit.

Unit 1.1 - Translational Hepatology and Stem Cell Biology

2017

Moslem M, Eggenschwiler R, Wichmann C, Buhmann R, Cantz T, Henschler R. Kindlin-2 Modulates the Survival, Differentiation, and Migration of Induced Pluripotent Cell-Derived Mesenchymal Stromal Cells. Stem Cells Int. 2017;2017:7316354.

Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Gohring G, Schmidt H, Sgodda M, Cantz T. In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. Biol Chem. 2017.

2016

Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p mimic inhibits acute liver failure. Nature communications. 2016;7:11916.

Thiesler CT, Cajic S, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weibetamann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Korner C, Schambach A, Rapp E, Buettner FF. Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG). Molecular & cellular proteomics : MCP. 2016;15(4):1435-52.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell stem cell. 2016;18(6):797-808.

Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, Adachi K, Jang YJ, Kim J, Oh KJ, Kwak TH, Hwang SI, You JS, Ko K, Koo SH, Sharma AD, Kim JH, Hui L, Cantz T, Scholer HR, Han DW. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell reports. 2016.

Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T. Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Cell Biol Int. 2016;40(5):534-48.

Fraguas MS, Eggenschwiler R, Hoepfner J, Schiavinato JL, Haddad R, Oliveira LH, Araujo AG, Zago MA, Panepucci RA, Cantz T. MicroRNA-29 impairs the early phase of reprogramming process by targeting active DNA demethylation enzymes and Wnt signaling. Stem cell research. 2016;19:21-30.

Eggenschwiler R, Moslem M, Fraguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wahner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Scientific reports. 2016;6:38198.

2015

Advena-Regnery B, Böhm K, Jung B, Rottländer K, Sgodda S. Sind Parthenoten Embryonen? Zur biologischen und normativen Einordnung von menschlichen Parthenoten. Zeitschrift für medizinische Ethik.2015. 61:63-79.

Kim J, Kim KP, Lim KT, Lee SC, Yoon J, Song G, Hwang SI, Scholer HR, Cantz T, Han DW. Generation of Integration-Free Induced Hepatocyte-Like Cells from Mouse Fibroblasts. Sci Rep. 2015;5:15706.

Katsirntaki K, Mauritz C, Olmer R, Schmeckebier S, Sgodda M, Puppe V, Eggenschwiler R, Duerr J, Schubert SC, Schmiedl A, Ochs M, Cantz T, Salwig I, Szibor M, Braun T, Rathert C, Martens A, Mall MA, Martin U. Bronchoalveolar Sublineage Specification of Pluripotent Stem Cells: Effect of Dexamethasone Plus Camp-Elevating Agents and Keratinocyte Growth Factor. Tissue Eng Part A. 2015;21(3-4):669-82.

Mobus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-199a-5p Inhibition Enhances the Liver Repopulation Ability of Human Embryonic Stem Cell-Derived Hepatic Cells. J Hepatol. 2015;62(1):101-10.

Cantz T, Sharma AD, Ott M. Concise Review: Cell Therapies for Hereditary Metabolic Liver Diseases-Concepts, Clinical Results, and Future Developments. Stem Cells. 2015;33(4):1055-62.

Moslem M, Eberle I, Weber I, Henschler R, Cantz T. Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support Cd34(Pos) Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction. Stem Cells Int. 2015;2015:843058. Epub 2015/07/18.

Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T. Rescue of DNA-Pk Signaling and T-Cell Differentiation by Targeted Genome Editing in a Prkdc Deficient Ipsc Disease Model. PLoS Genet. 2015;11(5):e1005239.

2014

Cantz T. Die Erzeugung von Gameten aus pluripotenten Stammzellen. In: Heinemann T, Dederer H-G, Cantz T, editors. Entwicklungsbiologische Totipotenz in Ethik und Recht. Göttingen: V&R unipress; 2014. p. 57-65.

Sgodda S. Das Kriterium der Pluripotenz aus naturwissenschaftlicher Perspektive. In: Heinemann T, Dederer HG, editors. Entwicklungsbiologische Totipotenz in Ethik und Recht. Göttingen: V&R unipress; 2014. p. 13-55.

Ott M, Cantz T, Schneider A, Manns MP. [Diagnosis and Therapies for Acute Liver Failure: Scientific Developments]. Internist (Berl). 2014;55(11):1288-95. Diagnostik und Behandlung des akuten Leberversagens: Wissenschaftliche Entwicklungen.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Kuehle J, Turan S, Cantz T, Hoffmann D, Suerth JD, Maetzig T, Zychlinski D, Klein C, Steinemann D, Baum C, Bode J, Schambach A. Modified Lentiviral Ltrs Allow Flp Recombinase-Mediated Cassette Exchange and in Vivo Tracing of "Factor-Free" Induced Pluripotent Stem Cells. Mol Ther. 2014;22(5):919-28.

Schott JW, Hoffmann D, Maetzig T, Muller FJ, Steinemann D, Zychlinski D, Cantz T, Baum C, Schambach A. Improved Retroviral Episome Transfer of Transcription Factors Enables Sustained Cell Fate Modification. Gene Ther. 2014;21(11):938-49.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

2013

Eberle I, Moslem M, Henschler R, Cantz T. Engineered Mscs from Patient-Specific Ips Cells. Adv Biochem Eng Biotechnol. 2013;130:1-17.

Pfaff N, Cantz T. From Skin to Blood: A New Member Joins the Iclub. Cell Stem Cell. 2013;13(2):131-3.

Yuan Q, Loya K, Rani B, Mobus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-221 Overexpression Accelerates Hepatocyte Proliferation During Liver Regeneration. Hepatology. 2013;57(1):299-310.

Gross B, Sgodda M, Rasche M, Schambach A, Gohring G, Schlegelberger B, Greber B, Linden T, Reinhardt D, Cantz T, Klusmann JH. Improved Generation of Patient-Specific Induced Pluripotent Stem Cells Using a Chemically-Defined and Matrigel-Based Approach. Curr Mol Med. 2013;13(5):765-76. Epub 2013/05/07.

Sgodda M, Mobus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T. Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells. Curr Mol Med. 2013;13(5):842-55.

Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U. Keratinocyte Growth Factor and Dexamethasone Plus Elevated Camp Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type Ii Cells. Tissue Eng Part A. 2013;19(7-8):938-51.

Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemann D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvak Z, Sarkadi B, Ivics Z. Sleeping Beauty Transposon-Based System for Cellular Reprogramming and Targeted Gene Insertion in Induced Pluripotent Stem Cells. Nucleic Acids Res. 2013;41(3):1829-47.

Sgodda M, Cantz T. Small but Significant: Inter- and Intrapatient Variations in Ips Cell-Based Disease Modeling. Mol Ther. 2013;21(1):5-7.

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med. 2013;2(9):641-54.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. A Ubiquitous Chromatin Opening Element Prevents Transgene Silencing in Pluripotent Stem Cells and Their Differentiated Progeny. Stem Cells. 2013;31(3):488-99.

2012

Advena-Regnerv B, Laimböck L, Rottländer K, Sgodda S. Totipotenz im Spannungsfeld von Biologie, Ethik und Recht. Zeitschrift für medizinische Ethik. 2012;58(3):217-36.

Kleger A, Mahaddalkar PU, Katz SF, Lechel A, Joo JY, Loya K, Lin Q, Hartmann D, Liebau S, Kraus JM, Cantz T, Kestler HA, Zaehres H, Scholer H, Rudolph KL. Increased Reprogramming Capacity of Mouse Liver Progenitor Cells, Compared with Differentiated Liver Cells, Requires the Baf Complex. Gastroenterology. 2012;142(4):907-17.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Lachmann N, Jagielska J, Heckl D, Brennig S, Pfaff N, Maetzig T, Modlich U, Cantz T, Gentner B, Schambach A, Moritz T. Microrna-150-Regulated Vectors Allow Lymphocyte-Sparing Transgene Expression in Hematopoietic Gene Therapy. Gene Ther. 2012;19(9):915-24.

Pfaff N, Moritz T, Thum T, Cantz T. Mirnas Involved in the Generation, Maintenance, and Differentiation of Pluripotent Cells. J Mol Med (Berl). 2012;90(7):747-52.

Gross B, Pittermann E, Reinhardt D, Cantz T, Klusmann JH. Prospects and Challenges of Reprogrammed Cells in Hematology and Oncology. Pediatr Hematol Oncol. 2012;29(6):507-28.

2011

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T. Mirna Screening Reveals a New Mirna Family Stimulating Ips Cell Generation Via Regulation of Meox2. EMBO Rep. 2011;12(11):1153-9.

Terwel D, Loschmann YN, Schmidt HH, Scholer HR, Cantz T, Heneka MT. Neuroinflammatory and Behavioural Changes in the Atp7b Mutant Mouse Model of Wilson's Disease. J Neurochem. 2011;118(1):105-12.

Tiemann U, Sgodda M, Warlich E, Ballmaier M, Scholer HR, Schambach A, Cantz T. Optimal Reprogramming Factor Stoichiometry Increases Colony Numbers and Affects Molecular Characteristics of Murine Induced Pluripotent Stem Cells. Cytometry A. 2011;79(6):426-35.

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T. Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases. PLoS One. 2011;6(12):e28911. Epub 2011/12/24.

Haake C, Bonk S, Parsiegla J, Tomala M, Loya K, Sgodda M, Cantz T, Schambach A, Kasper C, Scheper T. Comparison of the Activity and Pluripotency Maintaining Potential of Human Leukemia Inhibitory Factor (Lif) Produced in E.Coli and Cho Cells. BMC Proc. 2011;5 Suppl 8:P109.

Wu G, Gentile L, Do JT, Cantz T, Sutter J, Psathaki K, Arauzo-Bravo MJ, Ortmeier C, Scholer HR. Efficient Derivation of Pluripotent Stem Cells from Sirna-Mediated Cdx2-Deficient Mouse Embryos. Stem Cells Dev. 2011;20(3):485-93.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011;9(7):e1001099.

Eggenschwiler R, Loya K, Sgodda M, Andre F, Cantz T. Hepatic Differentiation of Murine Disease-Specific Induced Pluripotent Stem Cells Allows Disease Modelling in Vitro. Stem Cells Int. 2011;2011:924782.

Wurm M, Gross B, Sgodda M, Standker L, Muller T, Forssmann WG, Horn PA, Blasczyk R, Cantz T. Improved Lentiviral Gene Transfer into Human Embryonic Stem Cells Grown in Co-Culture with Murine Feeder and Stroma Cells. Biol Chem. 2011;392(10):887-95. Epub 2011/08/05.

Sharma AD, Narain N, Handel EM, Iken M, Singhal N, Cathomen T, Manns MP, Scholer HR, Ott M, Cantz T. Microrna-221 Regulates Fas-Induced Fulminant Liver Failure. Hepatology. 2011;53(5):1651-61.

Warlich E, Kuehle J, Cantz T, Brugman MH, Maetzig T, Galla M, Filipczyk AA, Halle S, Klump H, Scholer HR, Baum C, Schroeder T, Schambach A. Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming. Mol Ther. 2011;19(4):782-9.

2010

Zaehres H, Kogler G, Arauzo-Bravo MJ, Bleidissel M, Santourlidis S, Weinhold S, Greber B, Kim JB, Buchheiser A, Liedtke S, Eilken HM, Graffmann N, Zhao X, Meyer J, Reinhardt P, Burr B, Waclawczyk S, Ortmeier C, Uhrberg M, Scholer HR, Cantz T, Wernet P. Induction of Pluripotency in Human Cord Blood Unrestricted Somatic Stem Cells. Exp Hematol. 2010;38(9):809-18, 18 e1-2.

Voelkel C, Galla M, Maetzig T, Warlich E, Kuehle J, Zychlinski D, Bode J, Cantz T, Schambach A, Baum C. Protein Transduction from Retroviral Gag Precursors. Proc Natl Acad Sci U S A. 2010;107(17):7805-10.

Tomala M, Lavrentieva A, Moretti P, Rinas U, Kasper C, Stahl F, Schambach A, Warlich E, Martin U, Cantz T, Scheper T. Preparation of Bioactive Soluble Human Leukemia Inhibitory Factor from Recombinant Escherichia Coli Using Thioredoxin as Fusion Partner. Protein Expr Purif. 2010;73(1):51-7.

Schambach A, Cantz T, Baum C, Cathomen T. Generation and Genetic Modification of Induced Pluripotent Stem Cells. Expert Opin Biol Ther. 2010;10(7):1089-103.

Cantz T, Martin U. Induced Pluripotent Stem Cells: Characteristics and Perspectives. Adv Biochem Eng Biotechnol. 2010;123:107-26.

2009

Kriegeskotte C, Cantz T, Haberland J, Zibert A, Haier J, Kohler G, Scholer HR, Schmidt HH, Arlinghaus HF. Laser Secondary Neutral Mass Spectrometry for Copper Detection in Micro-Scale Biopsies. J Mass Spectrom. 2009;44(10):1417-22.

Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Norder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M. Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice. Am J Pathol. 2009;175(4):1483-92.

Loya K, Eggenschwiler R, Ko K, Sgodda M, Andre F, Bleidissel M, Scholer HR, Cantz T. Hepatic Differentiation of Pluripotent Stem Cells. Biol Chem. 2009;390(10):1047-55.

2008

Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M. Stem and Progenitor Cells for Liver Repopulation: Can We Standardise the Process from Bench to Bedside? Gut. 2009;58(4):594-603. Epub 2008/12/19.

Cantz T, Key G, Bleidissel M, Gentile L, Han DW, Brenne A, Scholer HR. Absence of Oct4 Expression in Somatic Tumor Cell Lines. Stem Cells. 2008;26(3):692-7.

Cantz T, Bleidissel M, Stehling M, Scholer HR. In Vitro Differentiation of Reprogrammed Murine Somatic Cells into Hepatic Precursor Cells. Biol Chem. 2008;389(7):889-96. Epub 2008/07/17.

Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Scholer HR, Ott M. Murine Embryonic Stem Cell-Derived Hepatic Progenitor Cells Engraft in Recipient Livers with Limited Capacity of Liver Tissue Formation. Cell Transplant. 2008;17(3):313-23.

Unit 1.2 - iPSCs for Disease Modelling, Drug Screening and Cell Therapy

2017

Rojas SV, Meier M, Zweigerdt R, Eckardt D, Rathert C, Schecker N, Schmitto JD, Rojas-Hernandez S, Martin U, Kutschka I, Haverich A, Martens A. Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure. Artificial organs. 2017;41(2):192-9.

Jara-Avaca M, Kempf H, Ruckert M, Robles-Diaz D, Franke A, de la Roche J, Fischer M, Malan D, Sasse P, Solodenko W, Drager G, Kirschning A, Martin U, Zweigerdt R. EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival. Stem cell reports. 2017.

2016

Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knorr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T. Stiff matrix induces switch to pure beta-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes. Basic research in cardiology. 2016;111(6):68.

Stanslowsky N, Jahn K, Venneri A, Naujock M, Haase A, Martin U, Frieling H, Wegner F. Functional effects of cannabinoids during dopaminergic specification of human neural precursors derived from induced pluripotent stem cells. Addiction biology. 2016.

Merkert S, Martin U. Targeted genome engineering using designer nucleases: State of the art and practical guidance for application in human pluripotent stem cells. Stem cell research. 2016;16(2):377-86.

Merkert S, Martin U. Site-Specific Genome Engineering in Human Pluripotent Stem Cells. International journal of molecular sciences. 2016;17(7).

Kropp C, Kempf H, Halloin C, Robles-Diaz D, Franke A, Scheper T, Kinast K, Knorpp T, Joos TO, Haverich A, Martin U, Zweigerdt R, Olmer R. Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors. Stem cells translational medicine. 2016;5(10):1289-301.

Klawitter S, Fuchs NV, Upton KR, Munoz-Lopez M, Shukla R, Wang J, Garcia-Canadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Lower J, Wolvetang EJ, Martin U, Ivics Z, Izsvak Z, Garcia-Perez JL, Faulkner GJ, Schumann GG. Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nature communications. 2016;7:10286.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature communications. 2016;7:13602.

Borger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C. Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions. Molecular medicine. 2016;22.

Beckmann A, Schubert M, Hainz N, Haase A, Martin U, Tschernig T, Meier C. Ultrastructural demonstration of Cx43 gap junctions in induced pluripotent stem cells from human cord blood. Histochemistry and cell biology. 2016;146(5):529-37.

2015

Martin U. Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis? Molecular and cellular pediatrics. 2015;2(1):15.

Effenberg A, Stanslowsky N, Klein A, Wesemann M, Haase A, Martin U, Dengler R, Grothe C, Ratzka A, Wegner F. Striatal Transplantation of Human Dopaminergic Neurons Differentiated From Induced Pluripotent Stem Cells Derived From Umbilical Cord Blood Using Lentiviral Reprogramming. Cell transplantation. 2015;24(10):2099-112.

Rojas SV*, Martens A*, Zweigerdt R, Baraki H, Rathert C, Schecker N, Rojas-Hernandez S, Schwanke K, Martin U, Haverich A, Kutschka I. Transplantation Effectiveness of Induced Pluripotent Stem Cells Is Improved by a Fibrinogen Biomatrix in an Experimental Model of Ischemic Heart Failure. Tissue Eng Part A. 2015;21(13-14):1991-2000. Epub 2015/04/14.

Martin U. Pluripotent Stem Cells for Disease Modeling and Drug Screening: New Perspectives for Treatment of Cystic Fibrosis? Mol Cell Pediatr. 2015;2(1):15.

Martin U. New Muscle for Old Hearts: Engineering Tissue from Pluripotent Stem Cells. Hum Gene Ther. 2015;26(5):305-11.

Kempf H*, Kropp C*, Olmer R, Martin U, Zweigerdt R. Cardiac Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Nat Protoc. 2015;10(9):1345-61.

Katsirntaki K, Mauritz C, Olmer R, Schmeckebier S, Sgodda M, Puppe V, Eggenschwiler R, Duerr J, Schubert SC, Schmiedl A, Ochs M, Cantz T, Salwig I, Szibor M, Braun T, Rathert C, Martens A, Mall MA, Martin U. Bronchoalveolar Sublineage Specification of Pluripotent Stem Cells: Effect of Dexamethasone Plus Camp-Elevating Agents and Keratinocyte Growth Factor. Tissue Eng Part A. 2015;21(3-4):669-82.

Effenberg A, Stanslowsky N, Klein A, Wesemann M, Haase A, Martin U, Dengler R, Grothe C, Ratzka A, Wegner F. Striatal Transplantation of Human Dopaminergic Neurons Differentiated from Induced Pluripotent Stem Cells Derived from Umbilical Cord Blood Using Lentiviral Reprogramming. Cell Transplant. 2015;24(10):2099-112.

2014

Zweigerdt R, Gruh I, Martin U. Your Heart on a Chip: Ipsc-Based Modeling of Barth-Syndrome-Associated Cardiomyopathy. Cell Stem Cell. 2014;15(1):9-11.

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9.

Stanslowsky N, Haase A, Martin U, Naujock M, Leffler A, Dengler R, Wegner F. Functional Differentiation of Midbrain Neurons from Human Cord Blood-Derived Induced Pluripotent Stem Cells. Stem Cell Res Ther. 2014;5(2):35.

Schwanke K, Merkert S, Kempf H, Hartung S, Jara-Avaca M, Templin C, Gohring G, Haverich A, Martin U, Zweigerdt R. Fast and Efficient Multitransgenic Modification of Human Pluripotent Stem Cells. Hum Gene Ther Methods. 2014;25(2):136-53.

Naujock M, Stanslowsky N, Reinhardt P, Sterneckert J, Haase A, Martin U, Kim KS, Dengler R, Wegner F, Petri S. Molecular and Functional Analyses of Motor Neurons Generated from Human Cord-Blood-Derived Induced Pluripotent Stem Cells. Stem Cells Dev. 2014;23(24):3011-20.

Merkert S, Wunderlich S, Bednarski C, Beier J, Haase A, Dreyer AK, Schwanke K, Meyer J, Gohring G, Cathomen T, Martin U. Efficient Designer Nuclease-Based Homologous Recombination Enables Direct Pcr Screening for Footprintless Targeted Human Pluripotent Stem Cells. Stem Cell Reports. 2014;2(1):107-18.

Martin U, Haverich A. Engineering Cardiac Muscle: New Ways to Refurbish Old Hearts? Eur J Cardiothorac Surg. 2014;45(2):216-9.

Martens A*, Rojas SV*, Baraki H, Rathert C, Schecker N, Zweigerdt R, Schwanke K, Rojas-Hernandez S, Martin U, Saito S, Schmitto JD, Haverich A, Kutschka I. Substantial Early Loss of Induced Pluripotent Stem Cells Following Transplantation in Myocardial Infarction. Artif Organs. 2014;38(11):978-84.

Martens A*, Rojas SV*, Baraki H, Rathert C, Schecker N, Hernandez SR, Schwanke K, Zweigerdt R, Martin U, Saito S, Haverich A, Kutschka I. Macroscopic Fluorescence Imaging: A Novel Technique to Monitor Retention and Distribution of Injected Microspheres in an Experimental Model of Ischemic Heart Failure. PLoS One. 2014;9(8):e101775.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Kempf H, Olmer R, Kropp C, Ruckert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Stem Cell Reports. 2014;3(6):1132-46.

2013

Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U. Keratinocyte Growth Factor and Dexamethasone Plus Elevated Camp Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type Ii Cells. Tissue Eng Part A. 2013;19(7-8):938-51.

Kues WA, Herrmann D, Barg-Kues B, Haridoss S, Nowak-Imialek M, Buchholz T, Streeck M, Grebe A, Grabundzija I, Merkert S, Martin U, Hall VJ, Rasmussen MA, Ivics Z, Hyttel P, Niemann H. Derivation and Characterization of Sleeping Beauty Transposon-Mediated Porcine Induced Pluripotent Stem Cells. Stem Cells Dev. 2013;22(1):124-35.

Kensah G, Roa Lara A, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Drager G, Ochs M, Haverich A, Gruh I, Martin U. Murine and Human Pluripotent Stem Cell-Derived Cardiac Bodies Form Contractile Myocardial Tissue in Vitro. Eur Heart J. 2013;34(15):1134-46.

Hartung S, Schwanke K, Haase A, David R, Franz WM, Martin U, Zweigerdt R. Directing Cardiomyogenic Differentiation of Human Pluripotent Stem Cells by Plasmid-Based Transient Overexpression of Cardiac Transcription Factors. Stem Cells Dev. 2013;22(7):1112-25.

Emmert MY, Emmert LS, Martens A, Ismail I, Schmidt-Richter I, Gawol A, Seifert B, Haverich A, Martin U, Gruh I. Higher Frequencies of Bcrp+ Cardiac Resident Cells in Ischaemic Human Myocardium. Eur Heart J. 2013;34(36):2830-8.

Dahlmann J, Krause A, Moller L, Kensah G, Mowes M, Diekmann A, Martin U, Kirschning A, Gruh I, Drager G. Fully Defined in Situ Cross-Linkable Alginate and Hyaluronic Acid Hydrogels for Myocardial Tissue Engineering. Biomaterials. 2013;34(4):940-51.

Dahlmann J, Kensah G, Kempf H, Skvorc D, Gawol A, Elliott DA, Dräger G, Zweigerdt R, Martin U, Gruh I. The Use of Agarose Microwells for Scalable Embryoid Body Formation and Cardiac Differentiation of Human and Murine Pluripotent Stem Cells. Biomaterials. 2013;34(10):2463-71.

Buta C, David R, Dressel R, Emgard M, Fuchs C, Gross U, Healy L, Hescheler J, Kolar R, Martin U, Mikkers H, Muller FJ, Schneider RK, Seiler AE, Spielmann H, Weitzer G. Reconsidering Pluripotency Tests: Do We Still Need Teratoma Assays? Stem Cell Res. 2013;11(1):552-62. Epub 2013/04/25.

2012

Templin C, Martin U. Nichtinvasiver Nachweis transplantierter iPSCs. Laborwelt. 2012;4:22

Martin U. Induced Pluripotent Stem Cells from Blood. In: Regenerative Therapy Using Blood-Derived Stem Cells. Allan DS, Strunk D, editors. Humana Press; 2012. p. 87-95. 14. Springer-Verlag, ISBN 978-1-61779-470-4.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84.

Templin C, Zweigerdt R, Schwanke K, Olmer R, Ghadri JR, Emmert MY, Muller E, Kuest SM, Cohrs S, Schibli R, Kronen P, Hilbe M, Reinisch A, Strunk D, Haverich A, Hoerstrup S, Luscher TF, Kaufmann PA, Landmesser U, Martin U. Transplantation and Tracking of Human-Induced Pluripotent Stem Cells in a Pig Model of Myocardial Infarction: Assessment of Cell Survival, Engraftment, and Distribution by Hybrid Single Photon Emission Computed Tomography/Computed Tomography of Sodium Iodide Symporter Transgene Expression. Circulation. 2012;126(4):430-9.

Olmer R, Lange A, Selzer S, Kasper C, Haverich A, Martin U, Zweigerdt R. Suspension Culture of Human Pluripotent Stem Cells in Controlled, Stirred Bioreactors. Tissue Eng Part C Methods. 2012;18(10):772-84.

Fiechter M, Ghadri JR, Sidler M, Martin U, Landmesser U, Kaufmann PA, Luscher TF, Templin C. Cardiac Quadruple-Fusion Imaging: A Brief Report on a Novel Integrated Multimodality Approach for in Vivo Visualization of Transplanted Stem Cells. Int J Cardiol. 2012;161(1):62-3.

Chen R, John J, Lavrentieva A, Müller S, Tomala M, Zhao Y, Zweigerdt R, Beutel S, Hitzmann B, Kasper C, Martin U, Rinas U, Stahl F, Scheper T. Cytokine Production Using Membrane Adsorbers: Human Basic Fibroblast Growth Factor Produced by Escherichia Coli. Engineering in Life Sciences. 2012;12(1):29-38.

2011

Grolms M, Olmer R, Martin U, Zweigerdt R. Facilitating scale up:controlled stem cell cultivation in stirred suspension bioreactors. Biotech International 19. 2011 (www.biotech-online.com & search 12630).

Zweigerdt R, Olmer R, Singh H, Haverich A, Martin U. Scalable Expansion of Human Pluripotent Stem Cells in Suspension Culture. Nat Protoc. 2011;6(5):689-700.

Palecek J, Zweigerdt R, Olmer R, Martin U, Kirschning A, Drager G. A Practical Synthesis of Rho-Kinase Inhibitor Y-27632 and Fluoro Derivatives and Their Evaluation in Human Pluripotent Stem Cells. Org Biomol Chem. 2011;9(15):5503-10.

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I. Induced Pluripotent Stem Cell (Ipsc)-Derived Flk-1 Progenitor Cells Engraft, Differentiate, and Improve Heart Function in a Mouse Model of Acute Myocardial Infarction. Eur Heart J. 2011;32(21):2634-41.

Martens A, Gruh I, Dimitroulis D, Rojas SV, Schmidt-Richter I, Rathert C, Khaladj N, Gawol A, Chikobava MG, Martin U, Haverich A, Kutschka I. Rhesus Monkey Cardiosphere-Derived Cells for Myocardial Restoration. Cytotherapy. 2011;13(7):864-72.

Kuetemeyer K, Kensah G, Heidrich M, Meyer H, Martin U, Gruh I, Heisterkamp A. Two-Photon Induced Collagen Cross-Linking in Bioartificial Cardiac Tissue. Opt Express. 2011;19(17):15996-6007.

Kensah G, Gruh I, Viering J, Schumann H, Dahlmann J, Meyer H, Skvorc D, Bar A, Akhyari P, Heisterkamp A, Haverich A, Martin U. A Novel Miniaturized Multimodal Bioreactor for Continuous in Situ Assessment of Bioartificial Cardiac Tissue During Stimulation and Maturation. Tissue Eng Part C Methods. 2011;17(4):463-73.

Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JT, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T. Microrna-24 Regulates Vascularity after Myocardial Infarction. Circulation. 2011;124(6):720-30.

2010

Mauritz C, Martin U. Embryonic Stem Cells: Differentiation into Respiratory Cell Derivatives. In Stem cells: organogenesis and cancer. Vol. 37/661 (2). S.R. Singh, editor. Transworld Research Networ. 2010. ISBN 978-81-7895-487-5.

Ozkan J, Martin U. "In Vitro Generation of Large Blood Vessels Is the Key Technology for the Generation and Implantation of Larger Dimension Tissue". Circulation. 2010;121(13):F76-F8.

Tomala M, Lavrentieva A, Moretti P, Rinas U, Kasper C, Stahl F, Schambach A, Warlich E, Martin U, Cantz T, Scheper T. Preparation of Bioactive Soluble Human Leukemia Inhibitory Factor from Recombinant Escherichia Coli Using Thioredoxin as Fusion Partner. Protein Expr Purif. 2010;73(1):51-7.

Olmer R, Haase A, Merkert S, Cui W, Palecek J, Ran C, Kirschning A, Scheper T, Glage S, Miller K, Curnow EC, Hayes ES, Martin U. Long Term Expansion of Undifferentiated Human Ips and Es Cells in Suspension Culture Using a Defined Medium. Stem Cell Res. 2010;5(1):51-64.

Hess C, Wiegmann B, Maurer AN, Fischer P, Moller L, Martin U, Hilfiker A, Haverich A, Fischer S. Reduced Thrombocyte Adhesion to Endothelialized Poly 4-Methyl-1-Pentene Gas Exchange Membranes-a First Step toward Bioartificial Lung Development. Tissue Eng Part A. 2010;16(10):3043-53.

Cantz T, Martin U. Induced Pluripotent Stem Cells: Characteristics and Perspectives. Adv Biochem Eng Biotechnol. 2010;123:107-26.

2009

Xaymardan M, Cimini M, Fazel S, Weisel RD, Lu WY, Martin U, Harvey RP, Li RK. C-Kit Function Is Necessary for in Vitro Myogenic Differentiation of Bone Marrow Hematopoietic Cells. Stem Cells. 2009;27(8):1911-20. Epub 2009/06/23.

Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR, Martin U. Generation of Induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell. 2009;5(4):434-41.

Gruh I, Martin U. Transdifferentiation of Stem Cells: A Critical View. Adv Biochem Eng Biotechnol. 2009;114:73-106.

Ghodsizad A, Niehaus M, Kogler G, Martin U, Wernet P, Bara C, Khaladj N, Loos A, Makoui M, Thiele J, Mengel M, Karck M, Klein HM, Haverich A, Ruhparwar A. Transplanted Human Cord Blood-Derived Unrestricted Somatic Stem Cells Improve Left-Ventricular Function and Prevent Left-Ventricular Dilation and Scar Formation after Acute Myocardial Infarction. Heart. 2009;95(1):27-35.

2008

Martin U. Pluripotent Nonhuman Primate Stem Cells for Biomedical Research, Development of Regenerative Therapies and Drug Screening. In Critical Contributions of Primate Models for Biopharmaceutical Drug Development. G. Weinbauer, editor. Waxmann, Münster. 2008.

Wunderlich S, Gruh I, Winkler ME, Beier J, Radtke K, Schmiedl A, Groos S, Haverich A, Martin U. Type Ii Pneumocyte-Restricted Green Fluorescent Protein Expression after Lentiviral Transduction of Lung Epithelial Cells. Hum Gene Ther. 2008;19(1):39-52.

Winkler ME, Mauritz C, Groos S, Kispert A, Menke S, Hoffmann A, Gruh I, Schwanke K, Haverich A, Martin U. Serum-Free Differentiation of Murine Embryonic Stem Cells into Alveolar Type Ii Epithelial Cells. Cloning Stem Cells. 2008;10(1):49-64.

Mauritz C, Schwanke K, Reppel M, Neef S, Katsirntaki K, Maier LS, Nguemo F, Menke S, Haustein M, Hescheler J, Hasenfuss G, Martin U. Generation of Functional Murine Cardiac Myocytes from Induced Pluripotent Stem Cells. Circulation. 2008;118(5):507-17.

Martin U. Methods for Studying Stem Cells: Adult Stem Cells for Lung Repair. Methods. 2008;45(2):121-32.

Gruh I, Wunderlich S, Winkler M, Schwanke K, Heinke J, Blomer U, Ruhparwar A, Rohde B, Li RK, Haverich A, Martin U. Human Cmv Immediate-Early Enhancer: A Useful Tool to Enhance Cell-Type-Specific Expression from Lentiviral Vectors. J Gene Med. 2008;10(1):21-32.

2007

Ruhparwar A, Er F, Martin U, Radke K, Gruh I, Niehaus M, Karck M, Haverich A, Hoppe UC. Enrichment of Cardiac Pacemaker-Like Cells: Neuregulin-1 and Cyclic Amp Increase I(F)-Current Density and Connexin 40 Mrna Levels in Fetal Cardiomyocytes. Med Biol Eng Comput. 2007;45(2):221-7.

2006

Schwarzer M, Carnwath JW, Lucas-Hahn A, Lemme E, Kues WA, Wachsmann B, Haverich A, Martin U, Niemann H. Isolation of Bovine Cardiomyocytes for Reprogramming Studies Based on Nuclear Transfer. Cloning Stem Cells. 2006;8(3):150-8.

Schwanke K, Wunderlich S, Reppel M, Winkler ME, Matzkies M, Groos S, Itskovitz-Eldor J, Simon AR, Hescheler J, Haverich A, Martin U. Generation and Characterization of Functional Cardiomyocytes from Rhesus Monkey Embryonic Stem Cells. Stem Cells. 2006;24(6):1423-32.

Ruhparwar A, Ghodsizad A, Niehaus M, Bara C, Lotz J, Voelkel T, Makoui M, Martin U, Wolf F, Gams E, Klein M, Haverich A. Clinically Applicable 7-Tesla Magnetic Resonance Visualization of Transplanted Human Adult Stem Cells Labeled with Clinimacs Nanoparticles. Thorac Cardiovasc Surg. 2006;54(7):447-51.

Ruhparwar A, Bara C, Kofidis T, Ruebesamen N, Karck M, Martin U, Haverich A. [in Vivo Detection of Integration of Grafted Cells after Myocardial Transplantation]. Zentralbl Chir. 2006;131(5):420-4. Bildgebende Verfahren zum In-vivo-Nachweis der Integration transplantierter Zellen im Myokard.

Li Y, Koster T, Morike C, v Horsten S, Martin U, Bader M, Haverich A, Simon AR. Pravastatin Prolongs Graft Survival in an Allogeneic Rat Model of Orthotopic Single Lung Transplantation. Eur J Cardiothorac Surg. 2006;30(3):515-24.

Horn PA, Tani K, Martin U, Niemann H. Nonhuman Primates: Embryonic Stem Cells and Transgenesis. Cloning Stem Cells. 2006;8(3):124-9.

Gruh I, Beilner J, Blomer U, Schmiedl A, Schmidt-Richter I, Kruse ML, Haverich A, Martin U. No Evidence of Transdifferentiation of Human Endothelial Progenitor Cells into Cardiomyocytes after Coculture with Neonatal Rat Cardiomyocytes. Circulation. 2006;113(10):1326-34.

Donath S, Li P, Willenbockel C, Al-Saadi N, Gross V, Willnow T, Bader M, Martin U, Bauersachs J, Wollert KC, Dietz R, von Harsdorf R. Apoptosis Repressor with Caspase Recruitment Domain Is Required for Cardioprotection in Response to Biomechanical and Ischemic Stress. Circulation. 2006;113(9):1203-12. Epub 2006/03/01.

Bara C, Ghodsizad A, Niehaus M, Makoui M, Piechaczek C, Martin U, Warnecke G, Karck M, Gams E, Klein HM, Haverich A, Ruhparwar A. In Vivo Echocardiographic Imaging of Transplanted Human Adult Stem Cells in the Myocardium Labeled with Clinically Applicable Clinimacs Nanoparticles. J Am Soc Echocardiogr. 2006;19(5):563-8.

2005

Ruhparwar A, Kofidis T, Ruebesamen N, Karck M, Haverich A, Martin U. Intra-Vital Fluorescence Microscopy for Intra-Myocardial Graft Detection Following Cell Transplantation. Int J Cardiovasc Imaging. 2005;21(5):569-74.

Gruh I, Schwanke K, Wunderlich S, Blomer U, Scherr M, Ganser A, Haverich A, Martin U. Shuttle System Allowing Simplified Cloning of Expression Cassettes into Advanced Generation Lentiviral Vectors. Biotechniques. 2005;38(4):530, 2, 4.

Blomer U, Gruh I, Witschel H, Haverich A, Martin U. Shuttle of Lentiviral Vectors Via Transplanted Cells in Vivo. Gene Ther. 2005;12(1):67-74.

Amit M, Winkler ME, Menke S, Bruning E, Buscher K, Denner J, Haverich A, Itskovitz-Eldor J, Martin U. No Evidence for Infection of Human Embryonic Stem Cells by Feeder Cell-Derived Murine Leukemia Viruses. Stem Cells. 2005;23(6):761-71. Epub 2005/05/27.

Additional Publications of the former Unit 18 W3-Professorship Cardiorespiratory Tissue-Engineering (2007 – 2012)

Wang S, Goecke T, Meixner C, Haverich A, Hilfiker A, Wolkers WF. Freeze-Dried Heart Valve Scaffolds. Tissue Eng Part C Methods. 2012;18(7):517-25.

Hoch M, Fischer P, Stapel B, Missol-Kolka E, Sekkali B, Scherr M, Favret F, Braun T, Eder M, Schuster-Gossler K, Gossler A, Hilfiker A, Balligand JL, Drexler H, Hilfiker-Kleiner D. Erythropoietin Preserves the Endothelial Differentiation Capacity of Cardiac Progenitor Cells and Reduces Heart Failure During Anticancer Therapies. Cell Stem Cell. 2011;9(2):131-43.

Hilfiker A, Kasper C, Hass R, Haverich A. Mesenchymal Stem Cells and Progenitor Cells in Connective Tissue Engineering and Regenerative Medicine: Is There a Future for Transplantation? Langenbecks Arch Surg. 2011;396(4):489-97.

Wernet P, Trapp T, Zweigerdt R, Mann J, Trompeter HI. Lentiviral Labeling Reveals Three Germ Layer Differentiation Potential of a Single Unrestricted Somatic Stem Cell from Human Cord Blood. Exp Hematol. 2010;38(11):1099-104.

Singh H, Mok P, Balakrishnan T, Rahmat SN, Zweigerdt R. Up-Scaling Single Cell-Inoculated Suspension Culture of Human Embryonic Stem Cells. Stem Cell Res. 2010;4(3):165-79.

Kuehn C, Graf K, Mashaqi B, Pichlmaier M, Heuer W, Hilfiker A, Stiesch M, Chaberny IF, Haverich A. Prevention of Early Vascular Graft Infection Using Regional Antibiotic Release. J Surg Res. 2010;164(1):e185-91. Epub 2010/09/11.

Kuehn C, Graf K, Heuer W, Hilfiker A, Chaberny IF, Stiesch M, Haverich A. Economic Implications of Infections of Implantable Cardiac Devices in a Single Institution. Eur J Cardiothorac Surg. 2010;37(4):875-9.

Hilfiker-Kleiner D, Shukla P, Klein G, Schaefer A, Stapel B, Hoch M, Muller W, Scherr M, Theilmeier G, Ernst M, Hilfiker A, Drexler H. Continuous Glycoprotein-130-Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction. Circulation. 2010;122(2):145-55.

Hata H, Bar A, Dorfman S, Vukadinovic Z, Sawa Y, Haverich A, Hilfiker A. Engineering a Novel Three-Dimensional Contractile Myocardial Patch with Cell Sheets and Decellularised Matrix. Eur J Cardiothorac Surg. 2010;38(4):450-5.

Cebotari S, Tudorache I, Jaekel T, Hilfiker A, Dorfman S, Ternes W, Haverich A, Lichtenberg A. Detergent Decellularization of Heart Valves for Tissue Engineering: Toxicological Effects of Residual Detergents on Human Endothelial Cells. Artif Organs. 2010;34(3):206-10.

Bar A, Dorfman SE, Fischer P, Hilfiker-Kleiner D, Cebotari S, Tudorache I, Suprunov M, Haverich A, Hilfiker A. The Pro-Angiogenic Factor Ccn1 Enhances the Re-Endothelialization of Biological Vascularized Matrices in Vitro. Cardiovasc Res. 2010;85(4):806-13.

Tudorache I, Kostin S, Meyer T, Teebken O, Bara C, Hilfiker A, Haverich A, Cebotari S. Viable Vascularized Autologous Patch for Transmural Myocardial Reconstruction. Eur J Cardiothorac Surg. 2009;36(2):306-11; discussion 11.

Baraki H, Tudorache I, Braun M, Hoffler K, Gorler A, Lichtenberg A, Bara C, Calistru A, Brandes G, Hewicker-Trautwein M, Hilfiker A, Haverich A, Cebotari S. Orthotopic Replacement of the Aortic Valve with Decellularized Allograft in a Sheep Model. Biomaterials. 2009;30(31):6240-6.

Tudorache I, Cebotari S, Sturz G, Kirsch L, Hurschler C, Hilfiker A, Haverich A, Lichtenberg A. Tissue Engineering of Heart Valves: Biomechanical and Morphological Properties of Decellularized Heart Valves. J Heart Valve Dis. 2007;16(5):567-73; discussion 74. Epub 2007/10/20.

Lichtenberg A, Cebotari S, Tudorache I, Hilfiker A, Haverich A. Biological Scaffolds for Heart Valve Tissue Engineering. Methods Mol Med. 2007;140:309-17.

Hilfiker-Kleiner D, Kaminski K, Podewski E, Bonda T, Schaefer A, Sliwa K, Forster O, Quint A, Landmesser U, Doerries C, Luchtefeld M, Poli V, Schneider MD, Balligand JL, Desjardins F, Ansari A, Struman I, Nguyen NQ, Zschemisch NH, Klein G, Heusch G, Schulz R, Hilfiker A, Drexler H. A Cathepsin D-Cleaved 16 Kda Form of Prolactin Mediates Postpartum Cardiomyopathy. Cell. 2007;128(3):589-600.

Bar A, Haverich A, Hilfiker A. Cardiac Tissue Engineering: "Reconstructing the Motor of Life". Scand J Surg. 2007;96(2):154-8. Epub 2007/08/08.

Aper T, Schmidt A, Duchrow M, Bruch HP. Autologous Blood Vessels Engineered from Peripheral Blood Sample. Eur J Vasc Endovasc Surg. 2007;33(1):33-9.

Unit 1.3 - iPSC based haemtopoietic regeneration

2016

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kuhnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem cell reports. 2016;7(2):292-305.

Borger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C. Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions. Molecular medicine. 2016;22.

2015

Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T. Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy. Leukemia. 2015;29(11):2266-9.

Lachmann N, Brennig S, Hillje R, Schermeier H, Phaltane R, Dahlmann J, Gruh I, Heinz N, Schiedlmeier B, Baum C, Moritz T. Tightly regulated 'all-in-one' lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy. Gene therapy. 2015;22(11):883-92.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T. TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells. Biomaterials. 2015;69:191-200.

Brennig S, Lachmann N, Buchegger T, Hetzel M, Schambach A, Moritz T. Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1). Journal of experimental & clinical cancer research : CR. 2015;34:148.

Brennig S, Lachmann N, Buchegger T, Hetzel M, Schambach A, Moritz T. Chemoprotection of Murine Hematopoietic Cells by Combined Gene Transfer of Cytidine Deaminase (Cdd) and Multidrug Resistance 1 Gene (Mdr1). Journal of Experimental & Clinical Cancer Research. 2015;34(1):1-12.

Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Luttge D, Buchegger T, Kuhnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T. Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies. Stem Cell Reports. 2015;4(2):282-96.

Ackermann M, Liebhaber S, Klusmann JH, Lachmann N. Lost in Translation: Pluripotent Stem Cell-Derived Hematopoiesis. EMBO Mol Med. 2015;7(11):1388-402.

Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T. Deoxycytidine-Kinase Knockdown as a Novel Myeloprotective Strategy in the Context of Fludarabine, Cytarabine or Cladribine Therapy. Leukemia. 2015;29(11):2266-9. Epub 2015/04/30.

Lachmann N, Brennig S, Hillje R, Schermeier H, Phaltane R, Dahlmann J, Gruh I, Heinz N, Schiedlmeier B, Baum C, Moritz T. Tightly Regulated 'All-in-One' Lentiviral Vectors for Protection of Human Hematopoietic Cells from Anticancer Chemotherapy. Gene Ther. 2015;22(11):883-92.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T. Talen-Mediated Functional Correction of X-Linked Chronic Granulomatous Disease in Patient-Derived Induced Pluripotent Stem Cells. Biomaterials. 2015;69:191-200.

Muller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M. A Minimal Ubiquitous Chromatin Opening Element (Ucoe) Effectively Prevents Silencing of Juxtaposed Heterologous Promoters by Epigenetic Remodeling in Multipotent and Pluripotent Stem Cells. Nucleic Acids Res. 2015;43(3):1577-92.

2014

Haemmerle R, Phaltane R, Rothe M, Schroder S, Schambach A, Moritz T, Modlich U. Clonal Dominance with Retroviral Vector Insertions near the Angpt1 and Angpt2 Genes in a Human Xenotransplant Mouse Model. Mol Ther Nucleic Acids. 2014;3:e200. Epub 2014/10/08.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82. Epub 2013/11/28.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

Phaltane R, Haemmerle R, Rothe M, Modlich U, Moritz T. Efficiency and Safety of O(6)-Methylguanine DNA Methyltransferase (Mgmt(P140k))-Mediated in Vivo Selection in a Humanized Mouse Model. Hum Gene Ther. 2014;25(2):144-55. Epub 2013/11/14.

Suzuki T, Arumugam P, Sakagami T, Lachmann N, Chalk C, Sallese A, Abe S, Trapnell C, Carey B, Moritz T, Malik P, Lutzko C, Wood RE, Trapnell BC. Pulmonary Macrophage Transplantation Therapy. Nature. 2014;514(7523):450-4. Epub 2014/10/03.

Happle C, Lachmann N, Skuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. Pulmonary Transplantation of Macrophage Progenitors as Effective and Long-Lasting Therapy for Hereditary Pulmonary Alveolar Proteinosis. Sci Transl Med. 2014;6(250):250ra113. Epub 2014/08/22.

Phaltane R, Lachmann N, Brennig S, Ackermann M, Modlich U, Moritz T. Lentiviral Mgmt(P140k)-Mediated in Vivo Selection Employing a Ubiquitous Chromatin Opening Element (A2ucoe) Linked to a Cellular Promoter. Biomaterials. 2014;35(25):7204-13. Epub 2014/05/31.

Lachmann N, Brennig S, Moritz T. Chapter 29 - Cytidine Deaminase in Myeloprotective Gene Therapy. In: Gerson ECLL, editor. Gene Therapy of Cancer (Third Edition). San Diego: Academic Press; 2014. p. 423-40.

2013

Kues WA, Herrmann D, Barg-Kues B, Haridoss S, Nowak-Imialek M, Buchholz T, Streeck M, Grebe A, Grabundzija I, Merkert S, Martin U, Hall VJ, Rasmussen MA, Ivics Z, Hyttel P, Niemann H. Derivation and Characterization of Sleeping Beauty Transposon-Mediated Porcine Induced Pluripotent Stem Cells. Stem Cells Dev. 2013;22(1):124-35.

Lachmann N, Brennig S, Pfaff N, Schermeier H, Dahlmann J, Phaltane R, Gruh I, Modlich U, Schambach A, Baum C, Moritz T. Efficient in Vivo Regulation of Cytidine Deaminase Expression in the Haematopoietic System Using a Doxycycline-Inducible Lentiviral Vector System. Gene Ther. 2013;20(3):298-307.

Pfaff N, Cantz T. From Skin to Blood: A New Member Joins the Iclub. Cell Stem Cell. 2013;13(2):131-3.

Lachmann N, Brennig S, Phaltane R, Flasshove M, Dilloo D, Moritz T. Myeloprotection by Cytidine Deaminase Gene Transfer in Antileukemic Therapy. Neoplasia. 2013;15(3):239-48.

Volkmann I, Kumarswamy R, Pfaff N, Fiedler J, Dangwal S, Holzmann A, Batkai S, Geffers R, Lother A, Hein L, Thum T. Microrna-Mediated Epigenetic Silencing of Sirtuin1 Contributes to Impaired Angiogenic Responses. Circ Res. 2013;113(8):997-1003.

Schambach A, Moritz T. Toward Position-Independent Retroviral Vector Expression in Pluripotent Stem Cells. Mol Ther. 2013;21(8):1474-7.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. A Ubiquitous Chromatin Opening Element Prevents Transgene Silencing in Pluripotent Stem Cells and Their Differentiated Progeny. Stem Cells. 2013;31(3):488-99.

2012

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Pfaff N, Moritz T, Thum T, Cantz T. Mirnas Involved in the Generation, Maintenance, and Differentiation of Pluripotent Cells. J Mol Med (Berl). 2012;90(7):747-52.

Lachmann N, Jagielska J, Heckl D, Brennig S, Pfaff N, Maetzig T, Modlich U, Cantz T, Gentner B, Schambach A, Moritz T. Microrna-150-Regulated Vectors Allow Lymphocyte-Sparing Transgene Expression in Hematopoietic Gene Therapy. Gene Ther. 2012;19(9):915-24.

Brennig S, Rattmann I, Lachmann N, Schambach A, Williams DA, Moritz T. In Vivo Enrichment of Cytidine Deaminase Gene-Modified Hematopoietic Cells by Prolonged Cytosine-Arabinoside Application. Cytotherapy. 2012;14(4):451-60.

2011

Giordano FA, Sorg UR, Appelt JU, Lachmann N, Bleier S, Roeder I, Kleff V, Flasshove M, Zeller WJ, Allgayer H, von Kalle C, Fruehauf S, Moritz T, Laufs S. Clonal Inventory Screens Uncover Monoclonality Following Serial Transplantation of Mgmt P140k-Transduced Stem Cells and Dose-Intense Chemotherapy. Hum Gene Ther. 2011;22(6):697-710.

Hauschild J, Petersen B, Santiago Y, Queisser AL, Carnwath JW, Lucas-Hahn A, Zhang L, Meng X, Gregory PD, Schwinzer R, Cost GJ, Niemann H. Efficient Generation of a Biallelic Knockout in Pigs Using Zinc-Finger Nucleases. Proc Natl Acad Sci U S A. 2011;108(29):12013-7.

Garrels W, Mates L, Holler S, Dalda A, Taylor U, Petersen B, Niemann H, Izsvak Z, Ivics Z, Kues WA. Germline Transgenic Pigs by Sleeping Beauty Transposition in Porcine Zygotes and Targeted Integration in the Pig Genome. PLoS One. 2011;6(8):e23573.

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T. Mirna Screening Reveals a New Mirna Family Stimulating Ips Cell Generation Via Regulation of Meox2. EMBO Rep. 2011;12(11):1153-9.

Nowak-Imialek M, Kues WA, Petersen B, Lucas-Hahn A, Herrmann D, Haridoss S, Oropeza M, Lemme E, Scholer HR, Carnwath JW, Niemann H. Oct4-Enhanced Green Fluorescent Protein Transgenic Pigs: A New Large Animal Model for Reprogramming Studies. Stem Cells Dev. 2011;20(9):1563-75.

Iqbal K, Kues WA, Baulain U, Garrels W, Herrmann D, Niemann H. Species-Specific Telomere Length Differences between Blastocyst Cell Compartments and Ectopic Telomere Extension in Early Bovine Embryos by Human Telomerase Reverse Transcriptase. Biol Reprod. 2011;84(4):723-33.

Aydin S, Grabellus F, Eisele L, Mollmann M, Hanoun M, Ebeling P, Moritz T, Carpinteiro A, Nuckel H, Sak A, Gothert JR, Duhrsen U, Durig J. Investigating the Role of Cd38 and Functionally Related Molecular Risk Factors in the Cll Nod/Scid Xenograft Model. Eur J Haematol. 2011;87(1):10-9.

2010

Nowak-Imialek M, Kues WA, Rudolph C, Schlegelberger B, Taylor U, Carnwath JW, Niemann H. Preferential Loss of Porcine Chromosomes in Reprogrammed Interspecies Cell Hybrids. Cell Reprogram. 2010;12(1):55-65.

Sanchez-Aguilera A, Rattmann I, Drew DZ, Muller LU, Summey V, Lucas DM, Byrd JC, Croce CM, Gu Y, Cancelas JA, Johnston P, Moritz T, Williams DA. Involvement of Rhoh Gtpase in the Development of B-Cell Chronic Lymphocytic Leukemia. Leukemia. 2010;24(1):97-104.

2009

Funke S, Schneider IC, Glaser S, Muhlebach MD, Moritz T, Cattaneo R, Cichutek K, Buchholz CJ. Pseudotyping Lentiviral Vectors with the Wild-Type Measles Virus Glycoproteins Improves Titer and Selectivity. Gene Ther. 2009;16(5):700-5.

2008

Kleff V, Sorg UR, Bury C, Suzuki T, Rattmann I, Jerabek-Willemsen M, Poremba C, Flasshove M, Opalka B, Trapnell B, Dirksen U, Moritz T. Gene Therapy of Beta(C)-Deficient Pulmonary Alveolar Proteinosis (Beta(C)-Pap): Studies in a Murine in Vivo Model. Mol Ther. 2008;16(4):757-64.

Kues WA, Sudheer S, Herrmann D, Carnwath JW, Havlicek V, Besenfelder U, Lehrach H, Adjaye J, Niemann H. Genome-Wide Expression Profiling Reveals Distinct Clusters of Transcriptional Regulation During Bovine Preimplantation Development in Vivo. Proc Natl Acad Sci U S A. 2008;105(50):19768-73.

Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, Thomale J, Williams DA. Reciprocal Relationship between O6-Methylguanine-DNA Methyltransferase P140k Expression Level and Chemoprotection of Hematopoietic Stem Cells. Cancer Res. 2008;68(15):6171-80.

Nowak-Imialek M, Wrenzycki C, Herrmann D, Lucas-Hahn A, Lagutina I, Lemme E, Lazzari G, Galli C, Niemann H. Messenger Rna Expression Patterns of Histone-Associated Genes in Bovine Preimplantation Embryos Derived from Different Origins. Mol Reprod Dev. 2008;75(5):731-43.

Unit 1.4 - Stem Cell Glycomics and Proteomics

2017

Shcherbakova A, Tiemann B, Buettner FF, Bakker H. Distinct C-mannosylation of netrin receptor thrombospondin type 1 repeats by mammalian DPY19L1 and DPY19L3. Proceedings of the National Academy of Sciences of the United States of America. 2017.

Boer U, Buettner FF, Schridde A, Klingenberg M, Sarikouch S, Haverich A, Wilhelmi M. Antibody formation towards porcine tissue in patients implanted with crosslinked heart valves is directed to antigenic tissue proteins and alphaGal epitopes and is reduced in healthy vegetarian subjects. Xenotransplantation. 2017.

2016

Werneburg S, Buettner FF, Erben L, Mathews M, Neumann H, Muhlenhoff M, Hildebrandt H. Polysialylation and lipopolysaccharide-induced shedding of E-selectin ligand-1 and neuropilin-2 by microglia and THP-1 macrophages. Glia. 2016;64(8):1314-30.

Thiesler CT, Cajic S, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weibetamann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Korner C, Schambach A, Rapp E, Buettner FF. Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG). Molecular & cellular proteomics : MCP. 2016;15(4):1435-52.

Kiermaier E, Moussion C, Veldkamp CT, Gerardy-Schahn R, de Vries I, Williams LG, Chaffee GR, Phillips AJ, Freiberger F, Imre R, Taleski D, Payne RJ, Braun A, Forster R, Mechtler K, Muhlenhoff M, Volkman BF, Sixt M. Polysialylation controls dendritic cell trafficking by regulating chemokine recognition. Science. 2016;351(6269):186-90.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature communications. 2016;7:13602.

Kallolimath S, Castilho A, Strasser R, Grunwald-Gruber C, Altmann F, Strubl S, Galuska CE, Zlatina K, Galuska SP, Werner S, Thiesler H, Werneburg S, Hildebrandt H, Gerardy-Schahn R, Steinkellner H. Engineering of complex protein sialylation in plants. Proceedings of the National Academy of Sciences of the United States of America. 2016;113(34):9498-503.

2015

Baumann AM, Bakkers MJ, Buettner FF, Hartmann M, Grove M, Langereis MA, de Groot RJ, Muhlenhoff M. 9-O-Acetylation of Sialic Acids Is Catalysed by Casd1 Via a Covalent Acetyl-Enzyme Intermediate. Nat Commun. 2015;6:7673. Epub 2015/07/15.

Niemann MC, Bartrina I, Ashikov A, Weber H, Novak O, Spichal L, Strnad M, Strasser R, Bakker H, Schmulling T, Werner T. Arabidopsis Rock1 Transports Udp-Glcnac/Udp-Galnac and Regulates Er Protein Quality Control and Cytokinin Activity. Proc Natl Acad Sci U S A. 2015;112(1):291-6.

Kruger AT, Engel J, Buettner FF, Routier FH. Aspergillus Fumigatus Cap59-Like Protein a Is Involved in Alpha1,3-Mannosylation of Gpi-Anchors. Glycobiology. 2015. Epub 2015/09/16.

Engel J, Schmalhorst PS, Kruger AT, Muller CT, Buettner FF, Routier FH. Characterization of an N-Acetylglucosaminyltransferase Involved in Aspergillus Fumigatus Zwitterionic Glycoinositolphosphoceramide Biosynthesis. Glycobiology. 2015.

Karsten CB, Buettner FF, Cajic S, Nehlmeier I, Neumann B, Klippert A, Sauermann U, Reichl U, Gerardy-Schahn R, Rapp E, Stahl-Hennig C, Pohlmann S. Exclusive Decoration of Simian Immunodeficiency Virus Env with High-Mannose Type N-Glycans Is Not Compatible with Mucosal Transmission in Rhesus Macaques. J Virol. 2015;89(22):11727-33. Epub 2015/09/12.

Damerow S, Hoppe C, Bandini G, Zarnovican P, Buettner FF, Ferguson MA, Routier FH. Leishmania Major Udp-Sugar Pyrophosphorylase Salvages Galactose for Glycoconjugate Biosynthesis. Int J Parasitol. 2015;45(12):783-90.

Yu H, Takeuchi M, LeBarron J, Kantharia J, London E, Bakker H, Haltiwanger RS, Li H, Takeuchi H. Notch-Modifying Xylosyltransferase Structures Support an Sni-Like Retaining Mechanism. Nat Chem Biol. 2015;11(11):847-54.

Werneburg S, Buettner FF, Muhlenhoff M, Hildebrandt H. Polysialic Acid Modification of the Synaptic Cell Adhesion Molecule Syncam 1 in Human Embryonic Stem Cell-Derived Oligodendrocyte Precursor Cells. Stem Cell Res. 2015;14(3):339-46.

Schwarzer D, Browning C, Stummeyer K, Oberbeck A, Muhlenhoff M, Gerardy-Schahn R, Leiman PG. Structure and Biochemical Characterization of Bacteriophage Phi92 Endosialidase. Virology. 2015;477:133-43. Epub 2014/12/06.

2014

Tsuchiya A, Lu WY, Weinhold B, Boulter L, Stutchfield BM, Williams MJ, Guest RV, Minnis-Lyons SE, MacKinnon AC, Schwarzer D, Ichida T, Nomoto M, Aoyagi Y, Gerardy-Schahn R, Forbes SJ. Polysialic Acid/Neural Cell Adhesion Molecule Modulates the Formation of Ductular Reactions in Liver Injury. Hepatology. 2014;60(5):1727-40. Epub 2014/03/04.

Romanow A, Keys TG, Stummeyer K, Freiberger F, Henrissat B, Gerardy-Schahn R. Dissection of Hexosyl- and Sialyltransferase Domains in the Bifunctional Capsule Polymerases from Neisseria Meningitidis W and Y Defines a New Sialyltransferase Family. J Biol Chem. 2014;289(49):33945-57. Epub 2014/10/25.

Kröcher T, Röckle I, Diederichs U, Weinhold B, Burkhardt H, Yanagawa Y, Gerardy-Schahn R, Hildebrandt H. A Crucial Role for Polysialic Acid in Developmental Interneuron Migration and the Establishment of Interneuron Densities in the Mouse Prefrontal Cortex. Development. 2014;141(15):3022-32. Epub 2014/07/06.

Konze SA, van Diepen L, Schroder A, Olmer R, Moller H, Pich A, Weissmann R, Kuss AW, Zweigerdt R, Buettner FF. Cleavage of E-Cadherin and Beta-Catenin by Calpain Affects Wnt Signaling and Spheroid Formation in Suspension Cultures of Human Pluripotent Stem Cells. Molecular & Cellular Proteomics. 2014;13(4):990-1007. Epub 2014/02/01.

Keys TG, Fuchs HL, Ehrit J, Alves J, Freiberger F, Gerardy-Schahn R. Engineering the Product Profile of a Polysialyltransferase. Nature Chemical Biology. 2014;10(6):437-42. Epub 2014/04/15.

Fiebig T, Berti F, Freiberger F, Pinto V, Claus H, Romano MR, Proietti D, Brogioni B, Stummeyer K, Berger M, Vogel U, Costantino P, Gerardy-Schahn R. Functional Expression of the Capsule Polymerase of Neisseria Meningitidis Serogroup X: A New Perspective for Vaccine Development. Glycobiology. 2014;24(2):150-8. Epub 2013/11/22.

Boeer U, Buettner FF, Klingenberg M, Antonopoulos GC, Meyer H, Haverich A, Wilhelmi M. Immunogenicity of Intensively Decellularized Equine Carotid Arteries Is Conferred by the Extracellular Matrix Protein Collagen Type Vi. PLoS One. 2014;9(8):e105964. Epub 2014/08/27.

Bartel J, Feuerstacke C, Galuska CE, Weinhold B, Gerardy-Schahn R, Geyer R, Munster-Kuhnel A, Middendorff R, Galuska SP. Laser Microdissection of Paraffin Embedded Tissue as a Tool to Estimate the Sialylation Status of Selected Cell Populations. Anal Chem. 2014;86(5):2326-31. Epub 2014/02/05.

2013

Sethi MK, Buettner FF, Ashikov A, Bakker H. In Vitro Assays of Orphan Glycosyltransferases and Their Application to Identify Notch Xylosyltransferases. Immunotherapy of Cancer: Methods and Protocols. 2013;1022:307-20. Epub 2013/06/15.

Rollenhagen M, Buettner FF, Reismann M, Jirmo AC, Grove M, Behrens GM, Gerardy-Schahn R, Hanisch FG, Muhlenhoff M. Polysialic Acid on Neuropilin-2 Is Exclusively Synthesized by the Polysialyltransferase St8siaiv and Attached to Mucin-Type O-Glycans Located between the B2 and C Domain. J Biol Chem. 2013;288(32):22880-92. Epub 2013/06/27.

Lee TV, Sethi MK, Leonardi J, Rana NA, Buettner FF, Haltiwanger RS, Bakker H, Jafar-Nejad H. Negative Regulation of Notch Signaling by Xylose. PLoS Genet. 2013;9(6):e1003547. Epub 2013/06/12.

Freiberger F, Böhm R, Schwarzer D, Gerardy-Schahn R, Haselhorst T, von Itzstein M. Defining a Substrate-Binding Model of a Polysialyltransferase. Chembiochem. 2013;14(15):1949-53. Epub 2013/09/07.

Elschami M, Scherr M, Philippens B, Gerardy-Schahn R. Reduction of Stat3 Expression Induces Mitochondrial Dysfunction and Autophagy in Cardiac Hl-1 Cells. Eur J Cell Biol. 2013;92(1):21-9. Epub 2012/10/30.

Buettner FF, Ashikov A, Tiemann B, Lehle L, Bakker H. C. Elegans Dpy-19 Is a C-Mannosyltransferase Glycosylating Thrombospondin Repeats. Mol Cell. 2013;50(2):295-302. Epub 2013/04/09.

Ashikov A, Buettner FF, Tiemann B, Gerardy-Schahn R, Bakker H. Large2 Generates the Same Xylose- and Glucuronic Acid-Containing Glycan Structures as Large. Glycobiology. 2013;23(3):303-9. Epub 2012/11/09.

2012

Weinhold B, Sellmeier M, Schaper W, Blume L, Philippens B, Kats E, Bernard U, Galuska SP, Geyer H, Geyer R, Worthmann K, Schiffer M, Groos S, Gerardy-Schahn R, Munster-Kuhnel AK. Deficits in Sialylation Impair Podocyte Maturation. Journal of the American Society of Nephrology. 2012;23(8):1319-28. Epub 2012/06/30.

Sethi MK, Buettner FF, Ashikov A, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H. Molecular Cloning of a Xylosyltransferase That Transfers the Second Xylose to O-Glucosylated Epidermal Growth Factor Repeats of Notch. J Biol Chem. 2012;287(4):2739-48. Epub 2011/11/26.

Schaper W, Bentrop J, Ustinova J, Blume L, Kats E, Tiralongo J, Weinhold B, Bastmeyer M, Munster-Kuhnel AK. Identification and Biochemical Characterization of Two Functional Cmp-Sialic Acid Synthetases in Danio Rerio. J Biol Chem. 2012;287(16):13239-48. Epub 2012/02/22.

2011

Buettner FF, Konze SA, Maas A, Gerlach GF. Proteomic and immunoproteomic characterization of a DIVA subunit vaccine against Actinobacillus pleuropneumoniae. Proteome Sci. 2011;9(1):23. Epub 2011/04/22.

Eggers K, Werneburg S, Schertzinger A, Abeln M, Schiff M, Scharenberg MA, Burkhardt H, Muhlenhoff M, Hildebrandt H. Polysialic acid controls NCAM signals at cell-cell contacts to regulate focal adhesion independent from FGF receptor activity. J Cell Sci. 2011;124(Pt 19):3279-91. Epub 2011/09/24.

2010

Galuska SP, Geyer H, Bleckmann C, Rohrich RC, Maass K, Bergfeld AK, Muhlenhoff M, Geyer R. Mass spectrometric fragmentation analysis of oligosialic and polysialic acids. Anal Chem. 2010;82(5):2059-66. Epub 2010/02/04. 

Galuska SP, Rollenhagen M, Kaup M, Eggers K, Oltmann-Norden I, Schiff M, Hartmann M, Weinhold B, Hildebrandt H, Geyer R, Muhlenhoff M, Geyer H. Synaptic cell adhesion molecule SynCAM 1 is a target for polysialylation in postnatal mouse brain. Proc Natl Acad Sci U S A. 2010;107(22):10250-5. Epub 2010/05/19. 

Schulz EC, Dickmanns A, Urlaub H, Schmitt A, Muhlenhoff M, Stummeyer K, Schwarzer D, Gerardy-Schahn R, Ficner R. Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding. Nat Struct Mol Biol. 2010;17(2):210-5. Epub 2010/02/02. 

Schulz EC, Schwarzer D, Frank M, Stummeyer K, Muhlenhoff M, Dickmanns A, Gerardy-Schahn R, Ficner R. Structural basis for the recognition and cleavage of polysialic acid by the bacteriophage K1F tailspike protein EndoNF. J Mol Biol. 2010;397(1):341-51. Epub 2010/01/26. 

Sethi MK, Buettner FF, Krylov VB, Takeuchi H, Nifantiev NE, Haltiwanger RS, Gerardy-Schahn R, Bakker H. Identification of glycosyltransferase 8 family members as xylosyltransferases acting on O-glucosylated notch epidermal growth factor repeats. J Biol Chem. 2010;285(3):1582-6. Epub 2009/11/27. 

2009

Bakker H, Oka T, Ashikov A, Yadav A, Berger M, Rana NA, Bai X, Jigami Y, Haltiwanger RS, Esko JD, Gerardy-Schahn R. Functional UDP-xylose transport across the endoplasmic reticulum/Golgi membrane in a Chinese hamster ovary cell mutant defective in UDP-xylose Synthase. J Biol Chem. 2009;284(4):2576-83. Epub 2008/11/26. 

Boztug K, Appaswamy G, Ashikov A, Schaffer AA, Salzer U, Diestelhorst J, Germeshausen M, Brandes G, Lee-Gossler J, Noyan F, Gatzke AK, Minkov M, Greil J, Kratz C, Petropoulou T, Pellier I, Bellanne-Chantelot C, Rezaei N, Monkemoller K, Irani-Hakimeh N, Bakker H, Gerardy-Schahn R, Zeidler C, Grimbacher B, Welte K, Klein C. A syndrome with congenital neutropenia and mutations in G6PC3. N Engl J Med. 2009;360(1):32-43. Epub 2009/01/02. 

Buettner FF, Bendalla IM, Bosse JT, Meens J, Nash JH, Hartig E, Langford PR, Gerlach GF. Analysis of the Actinobacillus pleuropneumoniae HlyX (FNR) regulon and identification of iron-regulated protein B as an essential virulence factor. Proteomics. 2009;9(9):2383-98. Epub 2009/04/04. 

Johswich A, Kraft B, Wuhrer M, Berger M, Deelder AM, Hokke CH, Gerardy-Schahn R, Bakker H. Golgi targeting of Drosophila melanogaster beta4GalNAcTB requires a DHHC protein family-related protein as a pilot. J Cell Biol. 2009;184(1):173-83. Epub 2009/01/14. 

Kahlisch D, Buettner FF, Naim HY, Gerlach GF. Glycoprotein analysis of porcine bronchoalveolar lavage fluid reveals potential biomarkers corresponding to resistance to Actinobacillus pleuropneumoniae infection. Vet Res. 2009;40(6):60. Epub 2009/07/30. 

Schwarzer D, Stummeyer K, Haselhorst T, Freiberger F, Rode B, Grove M, Scheper T, von Itzstein M, Muhlenhoff M, Gerardy-Schahn R. Proteolytic release of the intramolecular chaperone domain confers processivity to endosialidase F. J Biol Chem. 2009;284(14):9465-74. Epub 2009/02/05. 

2008

Galuska SP, Geyer R, Gerardy-Schahn R, Muhlenhoff M, Geyer H. Enzyme-dependent variations in the polysialylation of the neural cell adhesion molecule (NCAM) in vivo. J Biol Chem. 2008;283(1):17-28. Epub 2007/11/08. 

Oltmann-Norden I, Galuska SP, Hildebrandt H, Geyer R, Gerardy-Schahn R, Geyer H, Muhlenhoff M. Impact of the polysialyltransferases ST8SiaII and ST8SiaIV on polysialic acid synthesis during postnatal mouse brain development. J Biol Chem. 2008;283(3):1463-71. Epub 2007/11/30. 

Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H. Distinct contributions of beta 4GalNAcTA and beta 4GalNAcTB to Drosophila glycosphingolipid biosynthesis. Glycoconj J. 2008;25(2):167-75. Epub 2007/09/19. 

2007

Curreli S, Arany Z, Gerardy-Schahn R, Mann D, Stamatos NM. Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions. J Biol Chem. 2007;282(42):30346-56. Epub 2007/08/19. 

Galuska SP, Geyer R, Muhlenhoff M, Geyer H. Characterization of oligo- and polysialic acids by MALDI-TOF-MS. Anal Chem. 2007;79(18):7161-9. Epub 2007/08/21. 

Krylov V, Ustyuzhanina N, Grachev A, Bakker H, Nifantiev N. Stereoselective synthesis of the 3-aminopropyl glycosides of alpha-D-Xyl-(1 -> 3)beta-D-Glc and alpha-D-Xyl-(1 -> 3)-alpha-D-Xyl-(1 -> 3)-beta-D-Glc and of their corresponding N-octanoyl derivatives. Synthesis-Stuttgart. 2007(20):3147-54. 

Unit 2.1 - Notch Signalling and Ciliogenesis

2016

Weidemann M, Schuster-Gossler K, Stauber M, Wrede C, Hegermann J, Ott T, Boldt K, Beyer T, Serth K, Kremmer E, Blum M, Ueffing M, Gossler A. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development. 2016;143(24):4736-48.

Stauber M, Weidemann M, Dittrich-Breiholz O, Lobschat K, Alten L, Mai M, Beckers A, Kracht M, Gossler A. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Developmental biology. 2016.

Schuster-Gossler K, Cordes R, Muller J, Geffers I, Delany-Heiken P, Taft M, Preller M, Gossler A. Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1. Genetics. 2016;202(3):1119-33.

2015

Serth K, Schuster-Gossler K, Kremmer E, Hansen B, Marohn-Kohn B, Gossler A. O-Fucosylation of Dll3 Is Required for Its Function During Somitogenesis. PLoS One. 2015;10(4):e0123776. Epub 2015/04/10.

Preusse K, Tveriakhina L, Schuster-Gossler K, Gaspar C, Rosa AI, Henrique D, Gossler A, Stauber M. Context-Dependent Functional Divergence of the Notch Ligands Dll1 and Dll4 in Vivo. PLoS Genet. 2015;11(6):e1005328.

2014

Muller J, Rana NA, Serth K, Kakuda S, Haltiwanger RS, Gossler A. O-Fucosylation of the Notch Ligand Mdll1 by Pofut1 Is Dispensable for Ligand Function. PLoS One. 2014;9(2):e88571. Epub 2014/02/18.

Menon MB, Sawada A, Chaturvedi A, Mishra P, Schuster-Gossler K, Galla M, Schambach A, Gossler A, Forster R, Heuser M, Kotlyarov A, Kinoshita M, Gaestel M. Genetic Deletion of Sept7 Reveals a Cell Type-Specific Role of Septins in Microtubule Destabilization for the Completion of Cytokinesis. PLoS Genet. 2014;10(8):e1004558.

Braune EB, Schuster-Gossler K, Lyszkiewicz M, Serth K, Preusse K, Madlung J, Macek B, Krueger A, Gossler A. S/T Phosphorylation of Dll1 Is Required for Full Ligand Activity in Vitro but Dispensable for Dll1 Function in Vivo During Embryonic Patterning and Marginal Zone B Cell Development. Mol Cell Biol. 2014;34(7):1221-33. Epub 2014/01/23.

2013

Zender S, Nickeleit I, Wuestefeld T, Sorensen I, Dauch D, Bozko P, El-Khatib M, Geffers R, Bektas H, Manns MP, Gossler A, Wilkens L, Plentz R, Zender L, Malek NP. A Critical Role for Notch Signaling in the Formation of Cholangiocellular Carcinomas. Cancer Cell. 2013;23(6):784-95.

Redeker C, Schuster-Gossler K, Kremmer E, Gossler A. Normal Development in Mice over-Expressing the Intracellular Domain of Dll1 Argues against Reverse Signaling by Dll1 in Vivo. PLoS One. 2013;8(10):e79050.

2012

Alten L, Schuster-Gossler K, Eichenlaub MP, Wittbrodt B, Wittbrodt J, Gossler A. A Novel Mammal-Specific Three Partite Enhancer Element Regulates Node and Notochord-Specific Noto Expression. PLoS One. 2012;7(10):e47785.

Alten L, Schuster-Gossler K, Beckers A, Groos S, Ulmer B, Hegermann J, Ochs M, Gossler A. Differential Regulation of Node Formation, Nodal Ciliogenesis and Cilia Positioning by Noto and Foxj1. Development. 2012;139(7):1276-84.

2011

Hoch M, Fischer P, Stapel B, Missol-Kolka E, Sekkali B, Scherr M, Favret F, Braun T, Eder M, Schuster-Gossler K, Gossler A, Hilfiker A, Balligand JL, Drexler H, Hilfiker-Kleiner D. Erythropoietin Preserves the Endothelial Differentiation Capacity of Cardiac Progenitor Cells and Reduces Heart Failure During Anticancer Therapies. Cell Stem Cell. 2011;9(2):131-43.

Girós A, Grgur K, Gossler A, Costell M. Α5β1 Integrin-Mediated Adhesion to Fibronectin Is Required for Axis Elongation and Somitogenesis in Mice. PLoS ONE. 2011;6(7):e22002.

2009

Sorensen I, Adams RH, Gossler A. Dll1-Mediated Notch Activation Regulates Endothelial Identity in Mouse Fetal Arteries. Blood. 2009;113(22):5680-8.

Schuster-Gossler K, Harris B, Johnson KR, Serth J, Gossler A. Notch Signalling in the Paraxial Mesoderm Is Most Sensitive to Reduced Pofut1 Levels During Early Mouse Development. BMC Dev Biol. 2009;9:6. Epub 2009/01/24.

Rocha SF, Lopes SS, Gossler A, Henrique D. Dll1 and Dll4 Function Sequentially in the Retina and Pv2 Domain of the Spinal Cord to Regulate Neurogenesis and Create Cell Diversity. Dev Biol. 2009;328(1):54-65.

Feyerabend TB, Terszowski G, Tietz A, Blum C, Luche H, Gossler A, Gale NW, Radtke F, Fehling HJ, Rodewald HR. Deletion of Notch1 Converts Pro-T Cells to Dendritic Cells and Promotes Thymic B Cells by Cell-Extrinsic and Cell-Intrinsic Mechanisms. Immunity. 2009;30(1):67-79.

Benedito R, Roca C, Sorensen I, Adams S, Gossler A, Fruttiger M, Adams RH. The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis. Cell. 2009;137(6):1124-35. Epub 2009/06/16.

2008

Feller J, Schneider A, Schuster-Gossler K, Gossler A. Noncyclic Notch Activity in the Presomitic Mesoderm Demonstrates Uncoupling of Somite Compartmentalization and Boundary Formation. Genes Dev. 2008;22(16):2166-71.

Estrach S, Cordes R, Hozumi K, Gossler A, Watt FM. Role of the Notch Ligand Delta1 in Embryonic and Adult Mouse Epidermis. J Invest Dermatol. 2008;128(4):825-32.

2007

Limbourg A, Ploom M, Elligsen D, Sorensen I, Ziegelhoeffer T, Gossler A, Drexler H, Limbourg FP. Notch Ligand Delta-Like 1 Is Essential for Postnatal Arteriogenesis. Circ Res. 2007;100(3):363-71. Epub 2007/01/20.

Geffers I, Serth K, Chapman G, Jaekel R, Schuster-Gossler K, Cordes R, Sparrow DB, Kremmer E, Dunwoodie SL, Klein T, Gossler A. Divergent Functions and Distinct Localization of the Notch Ligands Dll1 and Dll3 in Vivo. J Cell Biol. 2007;178(3):465-76.

Cheng HT, Kim M, Valerius MT, Surendran K, Schuster-Gossler K, Gossler A, McMahon AP, Kopan R. Notch2, but Not Notch1, Is Required for Proximal Fate Acquisition in the Mammalian Nephron. Development. 2007;134(4):801-11. Epub 2007/01/19.

Beckers A, Alten L, Viebahn C, Andre P, Gossler A. The Mouse Homeobox Gene Noto Regulates Node Morphogenesis, Notochordal Ciliogenesis, and Left Right Patterning. Proc Natl Acad Sci U S A. 2007;104(40):15765-70.

Schuster-Gossler K, Cordes R, Gossler A. Premature Myogenic Differentiation and Depletion of Progenitor Cells Cause Severe Muscle Hypotrophy in Delta1 Mutants. Proc Natl Acad Sci U S A. 2007;104(2):537-42.

Unit 2.2 - Transcriptional Control of Organogenesis

2017

Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO molecular medicine. 2017;9(2):265-79.

2016

Stoetzer C, Doll T, Stueber T, Herzog C, Echtermeyer F, Greulich F, Rudat C, Kispert A, Wegner F, Leffler A. Tetrodotoxin-sensitive alpha-subunits of voltage-gated sodium channels are relevant for inhibition of cardiac sodium currents by local anesthetics. Naunyn-Schmiedeberg's archives of pharmacology. 2016;389(6):625-36.

Ludtke TH, Rudat C, Wojahn I, Weiss AC, Kleppa MJ, Kurz J, Farin HF, Moon A, Christoffels VM, Kispert A. Tbx2 and Tbx3 Act Downstream of Shh to Maintain Canonical Wnt Signaling during Branching Morphogenesis of the Murine Lung. Developmental cell. 2016;39(2):239-53.

Greulich F, Trowe MO, Leffler A, Stoetzer C, Farin HF, Kispert A. Misexpression of Tbx18 in cardiac chambers of fetal mice interferes with chamber-specific developmental programs but does not induce a pacemaker-like gene signature. Journal of molecular and cellular cardiology. 2016;97:140-9.

Greulich F, Rudat C, Farin HF, Christoffels VM, Kispert A. Lack of Genetic Interaction between Tbx18 and Tbx2/Tbx20 in Mouse Epicardial Development. PloS one. 2016;11(6):e0156787.

Arraf AA, Yelin R, Reshef I, Kispert A, Schultheiss TM. Establishment of the Visceral Embryonic Midline Is a Dynamic Process that Requires Bilaterally Symmetric BMP Signaling. Developmental cell. 2016;37(6):571-80.

2015

Andre P, Song H, Kim W, Kispert A, Yang Y. Wnt5a and Wnt11 Regulate Mammalian Anterior-Posterior Axis Elongation. Development. 2015;142(8):1516-27.

Vivante A, Kleppa MJ, Schulz J, Kohl S, Sharma A, Chen J, Shril S, Hwang DY, Weiss AC, Kaminski MM, Shukrun R, Kemper MJ, Lehnhardt A, Beetz R, Sanna-Cherchi S, Verbitsky M, Gharavi AG, Stuart HM, Feather SA, Goodship JA, Goodship TH, Woolf AS, Westra SJ, Doody DP, Bauer SB, Lee RS, Adam RM, Lu W, Reutter HM, Kehinde EO, Mancini EJ, Lifton RP, Tasic V, Lienkamp SS, Juppner H, Kispert A, Hildebrandt F. Mutations in Tbx18 Cause Dominant Urinary Tract Malformations Via Transcriptional Dysregulation of Ureter Development. Am J Hum Genet. 2015;97(2):291-301.

Lee KY, Singh MK, Ussar S, Wetzel P, Hirshman MF, Goodyear LJ, Kispert A, Kahn CR. Tbx15 Controls Skeletal Muscle Fibre-Type Determination and Muscle Metabolism. Nat Commun. 2015;6:8054.

Weiss AC, Kispert A. Eph/Ephrin Signaling in the Kidney and Lower Urinary Tract. Pediatr Nephrol. 2015.

Mobus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-199a-5p Inhibition Enhances the Liver Repopulation Ability of Human Embryonic Stem Cell-Derived Hepatic Cells. J Hepatol. 2015;62(1):101-10.

Hafner R, Bohnenpoll T, Rudat C, Schultheiss TM, Kispert A. Fgfr2 Is Required for the Expansion of the Early Adrenocortical Primordium. Mol Cell Endocrinol. 2015;413:168-77. Epub 2015/07/05.

2014

Bohnenpoll T, Trowe MO, Wojahn I, Taketo MM, Petry M, Kispert A. Canonical Wnt Signaling Regulates the Proliferative Expansion and Differentiation of Fibrocytes in the Murine Inner Ear. Dev Biol. 2014;391(1):54-65.

Weiss AC, Airik R, Bohnenpoll T, Greulich F, Foik A, Trowe MO, Rudat C, Costantini F, Adams RH, Kispert A. Nephric Duct Insertion Requires Epha4/Epha7 Signaling from the Pericloacal Mesenchyme. Development. 2014;141(17):3420-30.

Morosan-Puopolo G, Balakrishnan-Renuka A, Yusuf F, Chen J, Dai F, Zoidl G, Ludtke TH, Kispert A, Theiss C, Abdelsabour-Khalaf M, Brand-Saberi B. Wnt11 Is Required for Oriented Migration of Dermogenic Progenitor Cells from the Dorsomedial Lip of the Avian Dermomyotome. PLoS One. 2014;9(3):e92679. Epub 2014/03/29.

Airik R, Slaats GG, Guo Z, Weiss AC, Khan N, Ghosh A, Hurd TW, Bekker-Jensen S, Schroder JM, Elledge SJ, Andersen JS, Kispert A, Castelli M, Boletta A, Giles RH, Hildebrandt F. Renal-Retinal Ciliopathy Gene Sdccag8 Regulates DNA Damage Response Signaling. J Am Soc Nephrol. 2014;25(11):2573-83.

Briot A, Jaroszewicz A, Warren CM, Lu J, Touma M, Rudat C, Hofmann JJ, Airik R, Weinmaster G, Lyons K, Wang Y, Kispert A, Pellegrini M, Iruela-Arispe ML. Repression of Sox9 by Jag1 Is Continuously Required to Suppress the Default Chondrogenic Fate of Vascular Smooth Muscle Cells. Dev Cell. 2014;31(6):707-21. Epub 2014/12/24.

Bolt CC, Elso CM, Lu X, Pan F, Kispert A, Stubbs L. A Distant Downstream Enhancer Directs Essential Expression of Tbx18 in Urogenital Tissues. Dev Biol. 2014;392(2):483-93.

Bohnenpoll T, Kispert A. Ureter Growth and Differentiation. Semin Cell Dev Biol. 2014;36:21-30.

Chowdhury A, Herzog C, Hasselbach L, Khouzani HL, Zhang J, Hammerschmidt M, Rudat C, Kispert A, Gaestel M, Menon MB, Tudorache I, Hilfiker-Kleiner D, Muhlfeld C, Schmitto JD, Muller M, Theilmeier G. Expression of Fibulin-6 in Failing Hearts and Its Role for Cardiac Fibroblast Migration. Cardiovasc Res. 2014;103(4):509-20.

Rudat C, Grieskamp T, Rohr C, Airik R, Wrede C, Hegermann J, Herrmann BG, Schuster-Gossler K, Kispert A. Upk3b Is Dispensable for Development and Integrity of Urothelium and Mesothelium. PLoS One. 2014;9(11):e112112.

2013

Rudat C, Norden J, Taketo MM, Kispert A. Epicardial Function of Canonical Wnt-, Hedgehog-, Fgfr1/2-, and Pdgfra-Signalling. Cardiovasc Res. 2013;100(3):411-21.

Martin E, Caubit X, Airik R, Vola C, Fatmi A, Kispert A, Fasano L. Tshz3 and Sox9 Regulate the Timing of Smooth Muscle Cell Differentiation in the Ureter by Reducing Myocardin Activity. PLoS One. 2013;8(5):e63721.

Schaale K, Brandenburg J, Kispert A, Leitges M, Ehlers S, Reiling N. Wnt6 Is Expressed in Granulomatous Lesions of Mycobacterium Tuberculosis-Infected Mice and Is Involved in Macrophage Differentiation and Proliferation. Journal of Immunology. 2013;191(10):5182-95. Epub 2013/10/15.

Mommersteeg MT, Andrews WD, Ypsilanti AR, Zelina P, Yeh ML, Norden J, Kispert A, Chedotal A, Christoffels VM, Parnavelas JG. Slit-Roundabout Signaling Regulates the Development of the Cardiac Systemic Venous Return and Pericardium. Circ Res. 2013;112(3):465-75.

Greulich F, Kispert A. Epicardial Lineages. Journal of Developmental Biology. 2013;1(1):32.

Trowe MO, Zhao L, Weiss AC, Christoffels V, Epstein DJ, Kispert A. Inhibition of Sox2-Dependent Activation of Shh in the Ventral Diencephalon by Tbx3 Is Required for Formation of the Neurohypophysis. Development. 2013;140(11):2299-309. Epub 2013/05/16.

Wang Q, Lu J, Zhang S, Wang S, Wang W, Wang B, Wang F, Chen Q, Duan E, Leitges M, Kispert A, Wang H. Wnt6 Is Essential for Stromal Cell Proliferation During Decidualization in Mice. Biology of Reproduction. 2013;88(1):5. Epub 2012/11/24.

Seidl S, Braun U, Roos N, Li S, Ludtke TH, Kispert A, Leitges M. Phenotypical Analysis of Atypical Pkcs in Vivo Function Display a Compensatory System at Mouse Embryonic Day 7.5. PLoS One. 2013;8(5):e62756.

Ludtke TH, Farin HF, Rudat C, Schuster-Gossler K, Petry M, Barnett P, Christoffels VM, Kispert A. Tbx2 Controls Lung Growth by Direct Repression of the Cell Cycle Inhibitor Genes Cdkn1a and Cdkn1b. PLoS Genet. 2013;9(1):e1003189.

Farin HF, Ludtke TH, Schmidt MK, Placzko S, Schuster-Gossler K, Petry M, Christoffels VM, Kispert A. Tbx2 Terminates Shh/Fgf Signaling in the Developing Mouse Limb Bud by Direct Repression of Gremlin1. PLoS Genet. 2013;9(4):e1003467.

Bohnenpoll T, Bettenhausen E, Weiss AC, Foik AB, Trowe MO, Blank P, Airik R, Kispert A. Tbx18 Expression Demarcates Multipotent Precursor Populations in the Developing Urogenital System but Is Exclusively Required within the Ureteric Mesenchymal Lineage to Suppress a Renal Stromal Fate. Dev Biol. 2013;380(1):25-36.

2012

Kispert A, Gossler A. Chapter 2.1 - Early Mouse Development. In: Hedrich HJ, editor. The Laboratory Mouse (Second Edition). Boston: Academic Press; 2012. p. 117-43.

Norden J, Grieskamp T, Christoffels VM, Moorman AF, Kispert A. Partial Absence of Pleuropericardial Membranes in Tbx18- and Wt1-Deficient Mice. PLoS One. 2012;7(9):e45100.

Kispert A. No Muscle for a Damaged Heart: Thymosin Beta 4 Treatment after Myocardial Infarction Does Not Induce Myocardial Differentiation of Epicardial Cells. J Mol Cell Cardiol. 2012;52(1):10-2. Epub 2011/10/25.

Greulich F, Farin HF, Schuster-Gossler K, Kispert A. Tbx18 Function in Epicardial Development. Cardiovasc Res. 2012;96(3):476-83.

Rabe TI, Griesel G, Blanke S, Kispert A, Leitges M, van der Zwaag B, Burbach JP, Varoqueaux F, Mansouri A. The Transcription Factor Uncx4.1 Acts in a Short Window of Midbrain Dopaminergic Neuron Differentiation. Neural Dev. 2012;7:39.

Singh R, Hoogaars WM, Barnett P, Grieskamp T, Rana MS, Buermans H, Farin HF, Petry M, Heallen T, Martin JF, Moorman AF, t Hoen PA, Kispert A, Christoffels VM. Tbx2 and Tbx3 Induce Atrioventricular Myocardial Development and Endocardial Cushion Formation. Cell Mol Life Sci. 2012;69(8):1377-89.

Trowe MO, Airik R, Weiss AC, Farin HF, Foik AB, Bettenhausen E, Schuster-Gossler K, Taketo MM, Kispert A. Canonical Wnt Signaling Regulates Smooth Muscle Precursor Development in the Mouse Ureter. Development. 2012;139(17):3099-108.

Volker LA, Petry M, Abdelsabour-Khalaf M, Schweizer H, Yusuf F, Busch T, Schermer B, Benzing T, Brand-Saberi B, Kretz O, Hohne M, Kispert A. Comparative Analysis of Neph Gene Expression in Mouse and Chicken Development. Histochem Cell Biol. 2012;137(3):355-66.

Norden J, Kispert A. Wnt/Ctnnb1 Signaling and the Mesenchymal Precursor Pools of the Heart. Trends Cardiovasc Med. 2012;22(5):118-22.

Rudat C, Kispert A. Wt1 and Epicardial Fate Mapping. Circ Res. 2012;111(2):165-9.

2011

Merveille AC, Davis EE, Becker-Heck A, Legendre M, Amirav I, Bataille G, Belmont J, Beydon N, Billen F, Clement A, Clercx C, Coste A, Crosbie R, de Blic J, Deleuze S, Duquesnoy P, Escalier D, Escudier E, Fliegauf M, Horvath J, Hill K, Jorissen M, Just J, Kispert A, Lathrop M, Loges NT, Marthin JK, Momozawa Y, Montantin G, Nielsen KG, Olbrich H, Papon JF, Rayet I, Roger G, Schmidts M, Tenreiro H, Towbin JA, Zelenika D, Zentgraf H, Georges M, Lequarre AS, Katsanis N, Omran H, Amselem S. Ccdc39 Is Required for Assembly of Inner Dynein Arms and the Dynein Regulatory Complex and for Normal Ciliary Motility in Humans and Dogs. Nat Genet. 2011;43(1):72-8. Epub 2010/12/07.

Greulich F, Rudat C, Kispert A. Mechanisms of T-Box Gene Function in the Developing Heart. Cardiovasc Res. 2011;91(2):212-22.

Froese N, Kattih B, Breitbart A, Grund A, Geffers R, Molkentin JD, Kispert A, Wollert KC, Drexler H, Heineke J. Gata6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor Beta/Activin Receptor-Like Kinase 5 Signaling. J Biol Chem. 2011;286(7):5680-90.

Trowe MO, Maier H, Petry M, Schweizer M, Schuster-Gossler K, Kispert A. Impaired Stria Vascularis Integrity Upon Loss of E-Cadherin in Basal Cells. Dev Biol. 2011;359(1):95-107. Epub 2011/09/20.

Heeringa SF, Chernin G, Chaki M, Zhou W, Sloan AJ, Ji Z, Xie LX, Salviati L, Hurd TW, Vega-Warner V, Killen PD, Raphael Y, Ashraf S, Ovunc B, Schoeb DS, McLaughlin HM, Airik R, Vlangos CN, Gbadegesin R, Hinkes B, Saisawat P, Trevisson E, Doimo M, Casarin A, Pertegato V, Giorgi G, Prokisch H, Rotig A, Nurnberg G, Becker C, Wang S, Ozaltin F, Topaloglu R, Bakkaloglu A, Bakkaloglu SA, Muller D, Beissert A, Mir S, Berdeli A, Varpizen S, Zenker M, Matejas V, Santos-Ocana C, Navas P, Kusakabe T, Kispert A, Akman S, Soliman NA, Krick S, Mundel P, Reiser J, Nurnberg P, Clarke CF, Wiggins RC, Faul C, Hildebrandt F. Coq6 Mutations in Human Patients Produce Nephrotic Syndrome with Sensorineural Deafness. J Clin Invest. 2011;121(5):2013-24.

Grieskamp T, Rudat C, Ludtke TH, Norden J, Kispert A. Notch Signaling Regulates Smooth Muscle Differentiation of Epicardium-Derived Cells. Circ Res. 2011;108(7):813-23.

Norden J, Greulich F, Rudat C, Taketo MM, Kispert A. Wnt/Beta-Catenin Signaling Maintains the Mesenchymal Precursor Pool for Murine Sinus Horn Formation. Circ Res. 2011;109(6):e42-50.

2010

Norden J, Grieskamp T, Lausch E, van Wijk B, van den Hoff MJ, Englert C, Petry M, Mommersteeg MT, Christoffels VM, Niederreither K, Kispert A. Wt1 and Retinoic Acid Signaling in the Subcoelomic Mesenchyme Control the Development of the Pleuropericardial Membranes and the Sinus Horns. Circ Res. 2010;106(7):1212-20.

Mommersteeg MT, Dominguez JN, Wiese C, Norden J, de Gier-de Vries C, Burch JB, Kispert A, Brown NA, Moorman AF, Christoffels VM. The Sinus Venosus Progenitors Separate and Diversify from the First and Second Heart Fields Early in Development. Cardiovasc Res. 2010;87(1):92-101.

Christoffels VM, Smits GJ, Kispert A, Moorman AF. Development of the Pacemaker Tissues of the Heart. Circ Res. 2010;106(2):240-54.

Aanhaanen WT, Mommersteeg MT, Norden J, Wakker V, de Gier-de Vries C, Anderson RH, Kispert A, Moorman AF, Christoffels VM. Developmental Origin, Growth, and Three-Dimensional Architecture of the Atrioventricular Conduction Axis of the Mouse Heart. Circ Res. 2010;107(6):728-36.

Singh R, Kispert A. Tbx20, Smads, and the Atrioventricular Canal. Trends Cardiovasc Med. 2010;20(4):109-14.

2009

Christoffels VM, Grieskamp T, Norden J, Mommersteeg MT, Rudat C, Kispert A. Tbx18 and the Fate of Epicardial Progenitors. Nature. 2009;458(7240):E8-9; discussion E-10.

Kobayashi K, Luo M, Zhang Y, Wilkes DC, Ge G, Grieskamp T, Yamada C, Liu T-C, Huang G, Basson CT, Kispert A, Greenspan DS, Sato TN. Secreted Frizzled Related Protein 2 Is a Procollagen C Proteinase Enhancer with a Role in Myocardial Infarction-Associated Fibrosis. Nature cell biology. 2009;11(1):46-55.

Aanhaanen WT, Brons JF, Dominguez JN, Rana MS, Norden J, Airik R, Wakker V, de Gier-de Vries C, Brown NA, Kispert A, Moorman AF, Christoffels VM. The Tbx2+ Primary Myocardium of the Atrioventricular Canal Forms the Atrioventricular Node and the Base of the Left Ventricle. Circ Res. 2009;104(11):1267-74.

Ludtke TH, Christoffels VM, Petry M, Kispert A. Tbx3 Promotes Liver Bud Expansion During Mouse Development by Suppression of Cholangiocyte Differentiation. Hepatology. 2009;49(3):969-78.

Wiese C, Grieskamp T, Airik R, Mommersteeg MT, Gardiwal A, de Gier-de Vries C, Schuster-Gossler K, Moorman AF, Kispert A, Christoffels VM. Formation of the Sinus Node Head and Differentiation of Sinus Node Myocardium Are Independently Regulated by Tbx18 and Tbx3. Circ Res. 2009;104(3):388-97.

Singh R, Horsthuis T, Farin HF, Grieskamp T, Norden J, Petry M, Wakker V, Moorman AF, Christoffels VM, Kispert A. Tbx20 Interacts with Smads to Confine Tbx2 Expression to the Atrioventricular Canal. Circ Res. 2009;105(5):442-52.

2008

Farin HF, Mansouri A, Petry M, Kispert A. T-Box Protein Tbx18 Interacts with the Paired Box Protein Pax3 in the Development of the Paraxial Mesoderm. J Biol Chem. 2008;283(37):25372-80.

Winkler ME, Mauritz C, Groos S, Kispert A, Menke S, Hoffmann A, Gruh I, Schwanke K, Haverich A, Martin U. Serum-Free Differentiation of Murine Embryonic Stem Cells into Alveolar Type Ii Epithelial Cells. Cloning Stem Cells. 2008;10(1):49-64.

Lausch E, Hermanns P, Farin HF, Alanay Y, Unger S, Nikkel S, Steinwender C, Scherer G, Spranger J, Zabel B, Kispert A, Superti-Furga A. Tbx15 Mutations Cause Craniofacial Dysmorphism, Hypoplasia of Scapula and Pelvis, and Short Stature in Cousin Syndrome. Am J Hum Genet. 2008;83(5):649-55.

2007

Farin HF, Bussen M, Schmidt MK, Singh MK, Schuster-Gossler K, Kispert A. Transcriptional Repression by the T-Box Proteins Tbx18 and Tbx15 Depends on Groucho Corepressors. J Biol Chem. 2007;282(35):25748-5

Unit 2.3 - Regenerative Immunology

2017

Krueger A, Zietara N, Lyszkiewicz M. T Cell Development by the Numbers. Trends in immunology. 2017;38(2):128-39.

Fleige H, Forster R. Induction and Analysis of Bronchus-Associated Lymphoid Tissue. Methods in molecular biology. 2017;1559:185-98.

2016

Lee CW, Wohlan K, Dallmann I, Forster R, Ganser A, Krueger A, Scherr M, Eder M, Koenecke C. miR-181a Expression in Donor T Cells Modulates Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation. Journal of immunology. 2016;196(9):3927-34.

Blume J, Zur Lage S, Witzlau K, Georgiev H, Weiss S, Lyszkiewicz M, Zietara N, Krueger A. Overexpression of Valpha14Jalpha18 TCR promotes development of iNKT cells in the absence of miR-181a/b-1. Immunology and cell biology. 2016;94(8):741-6.

2015

Zietara N, Lyszkiewicz M, Puchalka J, Witzlau K, Reinhardt A, Forster R, Pabst O, Prinz I, Krueger A. Multicongenic fate mapping quantification of dynamics of thymus colonization. The Journal of experimental medicine. 2015;212(10):1589-601.

Sandrock I, Zietara N, Lyszkiewicz M, Oberdorfer L, Witzlau K, Krueger A, Prinz I. MicroRNA-181a/b-1 Is Not Required for Innate gammadelta NKT Effector Cell Development. PloS one. 2015;10(12):e0145010.

Zietara N, Lyszkiewicz M, Puchalka J, Witzlau K, Reinhardt A, Forster R, Pabst O, Prinz I, Krueger A. Multicongenic Fate Mapping Quantification of Dynamics of Thymus Colonization. J Exp Med. 2015;212(10):1589-601.

Regelin M, Blume J, Pommerencke J, Vakilzadeh R, Witzlau K, Lyszkiewicz M, Zietara N, Saran N, Schambach A, Krueger A. Responsiveness of Developing T Cells to Il-7 Signals Is Sustained by Mir-17 Approximately 92. J Immunol. 2015;195(10):4832-40. Epub 2015/10/18.

Lyszkiewicz M, Zietara N, Fohse L, Puchalka J, Diestelhorst J, Witzlau K, Prinz I, Schambach A, Krueger A. Limited Niche Availability Suppresses Murine Intrathymic Dendritic-Cell Development from Noncommitted Progenitors. Blood. 2015;125(3):457-64. Epub 2014/11/21.

2014

Zietara N, Lyszkiewicz M, Krueger A, Weiss S. B-Cell Modulation of Dendritic-Cell Function: Signals from the Far Side. Eur J Immunol. 2014;44(1):23-32.

Ugur M, Schulz O, Menon MB, Krueger A, Pabst O. Resident Cd4+ T Cells Accumulate in Lymphoid Organs after Prolonged Antigen Exposure. Nat Commun. 2014;5:4821.

Schulz O, Ugur M, Friedrichsen M, Radulovic K, Niess JH, Jalkanen S, Krueger A, Pabst O. Hypertrophy of Infected Peyer's Patches Arises from Global, Interferon-Receptor, and Cd69-Independent Shutdown of Lymphocyte Egress. Mucosal Immunol. 2014;7(4):892-904.

Braune EB, Schuster-Gossler K, Lyszkiewicz M, Serth K, Preusse K, Madlung J, Macek B, Krueger A, Gossler A. S/T Phosphorylation of Dll1 Is Required for Full Ligand Activity in Vitro but Dispensable for Dll1 Function in Vivo During Embryonic Patterning and Marginal Zone B Cell Development. Mol Cell Biol. 2014;34(7):1221-33. Epub 2014/01/23.

2013

Zietara N, Lyszkiewicz M, Witzlau K, Naumann R, Hurwitz R, Langemeier J, Bohne J, Sandrock I, Ballmaier M, Weiss S, Prinz I, Krueger A. Critical Role for Mir-181a/B-1 in Agonist Selection of Invariant Natural Killer T Cells. Proc Natl Acad Sci U S A. 2013;110(18):7407-12.

Zietara N, Lyszkiewicz M, Puchalka J, Pei G, Gutierrez MG, Lienenklaus S, Hobeika E, Reth M, Martins dos Santos VA, Krueger A, Weiss S. Immunoglobulins Drive Terminal Maturation of Splenic Dendritic Cells. Proc Natl Acad Sci U S A. 2013;110(6):2282-7.

2012

Saran N, Pommerencke J, Witzlau K, Regelin M, Krueger A. Extra-Thymic Physiological T Lineage Progenitor Activity Is Exclusively Confined to Cells Expressing Either Cd127, Cd90, or High Levels of Cd117. PLoS One. 2012;7(2):e30864. Epub 2012/02/23.

Haas JD, Ravens S, Duber S, Sandrock I, Oberdorfer L, Kashani E, Chennupati V, Fohse L, Naumann R, Weiss S, Krueger A, Forster R, Prinz I. Development of Interleukin-17-Producing Gammadelta T Cells Is Restricted to a Functional Embryonic Wave. Immunity. 2012;37(1):48-59. Epub 2012/07/10.

2011

Zietara N, Lyszkiewicz M, Krueger A, Weiss S. Icos-Dependent Stimulation of Nkt Cells by Marginal Zone B Cells. Eur J Immunol. 2011;41(11):3125-34.

Surdziel E, Cabanski M, Dallmann I, Lyszkiewicz M, Krueger A, Ganser A, Scherr M, Eder M. Enforced Expression of Mir-125b Affects Myelopoiesis by Targeting Multiple Signaling Pathways. Blood. 2011;117(16):4338-48.

Lyszkiewicz M, Witzlau K, Pommerencke J, Krueger A. Chemokine Receptor Cx3cr1 Promotes Dendritic Cell Development under Steady-State Conditions. Eur J Immunol. 2011;41(5):1256-65.

Krueger A. A Missing Link in Thymic Dendritic Cell Development. Eur J Immunol. 2011;41(8):2145-7.

Haas JD, Nistala K, Petermann F, Saran N, Chennupati V, Schmitz S, Korn T, Wedderburn LR, Forster R, Krueger A, Prinz I. Expression of Mirnas Mir-133b and Mir-206 in the Il17a/F Locus Is Co-Regulated with Il-17 Production in Alphabeta and Gammadelta T Cells. PLoS One. 2011;6(5):e20171. Epub 2011/06/04.

2010

Saran N, Lyszkiewicz M, Pommerencke J, Witzlau K, Vakilzadeh R, Ballmaier M, von Boehmer H, Krueger A. Multiple Extrathymic Precursors Contribute to T-Cell Development with Different Kinetics. Blood. 2010;115(6):1137-44.

Krueger A, Willenzon S, Lyszkiewicz M, Kremmer E, Forster R. Cc Chemokine Receptor 7 and 9 Double-Deficient Hematopoietic Progenitors Are Severely Impaired in Seeding the Adult Thymus. Blood. 2010;115(10):1906-12.

2009

Weber C, Krueger A, Munk A, Bode C, Van Veldhoven PP, Graler MH. Discontinued Postnatal Thymocyte Development in Sphingosine 1-Phosphate-Lyase-Deficient Mice. J Immunol. 2009;183(7):4292-301.

2008

Kreslavsky T, Garbe AI, Krueger A, von Boehmer H. T Cell Receptor-Instructed Alphabeta Versus Gammadelta Lineage Commitment Revealed by Single-Cell Analysis. J Exp Med. 2008;205(5):1173-86.

2007

Krueger A, von Boehmer H. Identification of a T Lineage-Committed Progenitor in Adult Blood. Immunity. 2007;26(1):105-16.

Junt T, Schulze H, Chen Z, Massberg S, Goerge T, Krueger A, Wagner DD, Graf T, Italiano JE, Jr., Shivdasani RA, von Andrian UH. Dynamic Visualization of Thrombopoiesis within Bone Marrow. Science. 2007;317(5845):1767-70. Epub 2007/09/22.

2006

Krueger A, Garbe AI, von Boehmer H. Phenotypic Plasticity of T Cell Progenitors Upon Exposure to Notch Ligands. J Exp Med. 2006;203(8):1977-84. Epub 2006/07/19.

Garbe AI, Krueger A, Gounari F, Zuniga-Pflucker JC, von Boehmer H. Differential Synergy of Notch and T Cell Receptor Signaling Determines Alphabeta Versus Gammadelta Lineage Fate. J Exp Med. 2006;203(6):1579-90.

Unit 2.4 - Zebrafish Cardiovascular Development Genetics

2016

Haack T, Abdelilah-Seyfried S. The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis. Development. 2016;143(3):373-86.

Garcia de Vinuesa A, Abdelilah-Seyfried S, Knaus P, Zwijsen A, Bailly S. BMP signaling in vascular biology and dysfunction. Cytokine & growth factor reviews. 2016;27:65-79.

Cui H, Schlesinger J, Schoenhals S, Tonjes M, Dunkel I, Meierhofer D, Cano E, Schulz K, Berger MF, Haack T, Abdelilah-Seyfried S, Bulyk ML, Sauer S, Sperling SR. Phosphorylation of the chromatin remodeling factor DPF3a induces cardiac hypertrophy through releasing HEY repressors from DNA. Nucleic acids research. 2016;44(6):2538-53.

Dittmar F, Abdelilah-Seyfried S, Tschirner SK, Kaever V, Seifert R. Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish. Biochemical and biophysical research communications. 2015;468(4):708-12.

Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, Duchene J, Mickoleit M, Dietrich AC, Ramspacher C, Steed E, Manet-Dupe S, Benz A, Hassel D, Vermot J, Huisken J, Tournier-Lasserve E, Felbor U, Sure U, Albiges-Rizo C, Abdelilah-Seyfried S. Regulation of Beta1 Integrin-Klf2-Mediated Angiogenesis by Ccm Proteins. Dev Cell. 2015;32(2):181-90.

Lombardo VA, Otten C, Abdelilah-Seyfried S. Large-Scale Zebrafish Embryonic Heart Dissection for Transcriptional Analysis. J Vis Exp. 2015(95):52087.

Dittmar F, Abdelilah-Seyfried S, Tschirner SK, Kaever V, Seifert R. Temporal and Organ-Specific Detection of Cnmps Including Cump in the Zebrafish. Biochem Biophys Res Commun. 2015. Epub 2015/11/10.

Cui H, Schlesinger J, Schoenhals S, Tonjes M, Dunkel I, Meierhofer D, Cano E, Schulz K, Berger MF, Haack T, Abdelilah-Seyfried S, Bulyk ML, Sauer S, Sperling SR. Phosphorylation of the Chromatin Remodeling Factor Dpf3a Induces Cardiac Hypertrophy through Releasing Hey Repressors from DNA. Nucleic Acids Res. 2015. Epub 2015/11/20.

2014

Dietrich AC, Lombardo VA, Veerkamp J, Priller F, Abdelilah-Seyfried S. Blood Flow and Bmp Signaling Control Endocardial Chamber Morphogenesis. Dev Cell. 2014;30(4):367-77.

Bennet M, Akiva A, Faivre D, Malkinson G, Yaniv K, Abdelilah-Seyfried S, Fratzl P, Masic A. Simultaneous Raman Microspectroscopy and Fluorescence Imaging of Bone Mineralization in Living Zebrafish Larvae. Biophys J. 2014;106(4):L17-9.

2013

Wieffer M, Cibrian Uhalte E, Posor Y, Otten C, Branz K, Schutz I, Mossinger J, Schu P, Abdelilah-Seyfried S, Krauss M, Haucke V. Pi4k2beta/Ap-1-Based Tgn-Endosomal Sorting Regulates Wnt Signaling. Curr Biol. 2013;23(21):2185-90.

Veerkamp J, Rudolph F, Cseresnyes Z, Priller F, Otten C, Renz M, Schaefer L, Abdelilah-Seyfried S. Unilateral Dampening of Bmp Activity by Nodal Generates Cardiac Left-Right Asymmetry. Dev Cell. 2013;24(6):660-7.

Tay HG, Schulze SK, Compagnon J, Foley FC, Heisenberg CP, Yost HJ, Abdelilah-Seyfried S, Amack JD. Lethal Giant Larvae 2 Regulates Development of the Ciliated Organ Kupffer's Vesicle. Development. 2013;140(7):1550-9.

Otten C, Abdelilah-Seyfried S. Laser-Inflicted Injury of Zebrafish Embryonic Skeletal Muscle. J Vis Exp. 2013(71):e4351.

2012

Zhang J, Liss M, Wolburg H, Blasig IE, Abdelilah-Seyfried S. Involvement of Claudins in Zebrafish Brain Ventricle Morphogenesis. Ann N Y Acad Sci. 2012;1257:193-8.

Otten C, van der Ven PF, Lewrenz I, Paul S, Steinhagen A, Busch-Nentwich E, Eichhorst J, Wiesner B, Stemple D, Strahle U, Furst DO, Abdelilah-Seyfried S. Xirp Proteins Mark Injured Skeletal Muscle in Zebrafish. PLoS One. 2012;7(2):e31041.

Lombardo VA, Sporbert A, Abdelilah-Seyfried S. Cell Tracking Using Photoconvertible Proteins During Zebrafish Development. J Vis Exp. 2012(67). Epub 2012/10/12.

de Pater E, Ciampricotti M, Priller F, Veerkamp J, Strate I, Smith K, Lagendijk AK, Schilling TF, Herzog W, Abdelilah-Seyfried S, Hammerschmidt M, Bakkers J. Bmp Signaling Exerts Opposite Effects on Cardiac Differentiation. Circ Res. 2012;110(4):578-87.

Cibrian Uhalte E, Kirchner M, Hellwig N, Allen JJ, Donat S, Shokat KM, Selbach M, Abdelilah-Seyfried S. In Vivo Conditions to Identify Prkci Phosphorylation Targets Using the Analog-Sensitive Kinase Method in Zebrafish. PLoS One. 2012;7(6):e40000. Epub 2012/07/07.

2011

Kur E, Christa A, Veth KN, Gajera CR, Andrade-Navarro MA, Zhang J, Willer JR, Gregg RG, Abdelilah-Seyfried S, Bachmann S, Link BA, Hammes A, Willnow TE. Loss of Lrp2 in Zebrafish Disrupts Pronephric Tubular Clearance but Not Forebrain Development. Dev Dyn. 2011;240(6):1567-77. Epub 2011/04/02.

Klein C, Mikutta J, Krueger J, Scholz K, Brinkmann J, Liu D, Veerkamp J, Siegel D, Abdelilah-Seyfried S, le Noble F. Neuron Navigator 3a Regulates Liver Organogenesis During Zebrafish Embryogenesis. Development. 2011;138(10):1935-45.

Ghani S, Riemke P, Schonheit J, Lenze D, Stumm J, Hoogenkamp M, Lagendijk A, Heinz S, Bonifer C, Bakkers J, Abdelilah-Seyfried S, Hummel M, Rosenbauer F. Macrophage Development from Hscs Requires Pu.1-Coordinated Microrna Expression. Blood. 2011;118(8):2275-84.

2010

Zhang J, Piontek J, Wolburg H, Piehl C, Liss M, Otten C, Christ A, Willnow TE, Blasig IE, Abdelilah-Seyfried S. Establishment of a Neuroepithelial Barrier by Claudin5a Is Essential for Zebrafish Brain Ventricular Lumen Expansion. Proc Natl Acad Sci U S A. 2010;107(4):1425-30. Epub 2010/01/19.

Abdelilah-Seyfried S. Claudin-5a in Developing Zebrafish Brain Barriers: Another Brick in the Wall. Bioessays. 2010;32(9):768-76. Epub 2010/07/24.

2009

Seipold S, Priller FC, Goldsmith P, Harris WA, Baier H, Abdelilah-Seyfried S. Non-Smc Condensin I Complex Proteins Control Chromosome Segregation and Survival of Proliferating Cells in the Zebrafish Neural Retina. BMC Dev Biol. 2009;9:40.

Nyholm MK, Abdelilah-Seyfried S, Grinblat Y. A Novel Genetic Mechanism Regulates Dorsolateral Hinge-Point Formation During Zebrafish Cranial Neurulation. J Cell Sci. 2009;122(Pt 12):2137-48.

Hava D, Forster U, Matsuda M, Cui S, Link BA, Eichhorst J, Wiesner B, Chitnis A, Abdelilah-Seyfried S. Apical Membrane Maturation and Cellular Rosette Formation During Morphogenesis of the Zebrafish Lateral Line. J Cell Sci. 2009;122(Pt 5):687-95.

Bakkers J, Verhoeven MC, Abdelilah-Seyfried S. Shaping the Zebrafish Heart: From Left-Right Axis Specification to Epithelial Tissue Morphogenesis. Dev Biol. 2009;330(2):213-20.

2008

Rohr S, Otten C, Abdelilah-Seyfried S. Asymmetric Involution of the Myocardial Field Drives Heart Tube Formation in Zebrafish. Circ Res. 2008;102(2):e12-9.

Munson C, Huisken J, Bit-Avragim N, Kuo T, Dong PD, Ober EA, Verkade H, Abdelilah-Seyfried S, Stainier DY. Regulation of Neurocoel Morphogenesis by Pard6 Gamma B. Dev Biol. 2008;324(1):41-54.

Lange M, Kaynak B, Forster UB, Tonjes M, Fischer JJ, Grimm C, Schlesinger J, Just S, Dunkel I, Krueger T, Mebus S, Lehrach H, Lurz R, Gobom J, Rottbauer W, Abdelilah-Seyfried S, Sperling S. Regulation of Muscle Development by Dpf3, a Novel Histone Acetylation and Methylation Reader of the Baf Chromatin Remodeling Complex. Genes Dev. 2008;22(17):2370-84.

Bit-Avragim N, Rohr S, Rudolph F, Van der Ven P, Furst D, Eichhorst J, Wiesner B, Abdelilah-Seyfried S. Nuclear Localization of the Zebrafish Tight Junction Protein Nagie Oko. Dev Dyn. 2008;237(1):83-90.

Bit-Avragim N, Hellwig N, Rudolph F, Munson C, Stainier DY, Abdelilah-Seyfried S. Divergent Polarization Mechanisms During Vertebrate Epithelial Development Mediated by the Crumbs Complex Protein Nagie Oko. J Cell Sci. 2008;121(Pt 15):2503-10.

2007

Cui S, Otten C, Rohr S, Abdelilah-Seyfried S, Link BA. Analysis of Apkclambda and Apkczeta Reveals Multiple and Redundant Functions During Vertebrate Retinogenesis. Mol Cell Neurosci. 2007;34(3):431-44.

Cibrian-Uhalte E, Langenbacher A, Shu X, Chen JN, Abdelilah-Seyfried S. Involvement of Zebrafish Na+,K+ Atpase in Myocardial Cell Junction Maintenance. J Cell Biol. 2007;176(2):223-30. Epub 2007/01/18.

2006

Anzenberger U, Bit-Avragim N, Rohr S, Rudolph F, Dehmel B, Willnow TE, Abdelilah-Seyfried S. Elucidation of Megalin/Lrp2-Dependent Endocytic Transport Processes in the Larval Zebrafish Pronephros. J Cell Sci. 2006;119(Pt 10):2127-37.

Rohr S, Bit-Avragim N, Abdelilah-Seyfried S. Heart and Soul/Prkci and Nagie Oko/Mpp5 Regulate Myocardial Coherence and Remodeling During Cardiac Morphogenesis. Development. 2006;133(1):107-15.

Unit 3.1 - Molecular Mechanisms of Endogenous Liver Regeneration

2016

Ritorto MS, Rhode H, Vogel A, Borlak J. Regulation of glycosylphosphatidylinositol-anchored proteins and GPI-phospholipase D in a c-Myc transgenic mouse model of hepatocellular carcinoma and human HCC. Biol Chem. 2016;397(11):1147-62.

Endig J, Buitrago-Molina LE, Marhenke S, Reisinger F, Saborowski A, Schutt J, Limbourg F, Konecke C, Schreder A, Michael A, Misslitz AC, Healy ME, Geffers R, Clavel T, Haller D, Unger K, Finegold M, Weber A, Manns MP, Longerich T, Heikenwalder M, Vogel A. Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development. Cancer Cell. 2016;30(2):308-23.

2015

Orlik J, Schungel S, Buitrago-Molina LE, Marhenke S, Geffers R, Endig J, Lobschat K, Rossler S, Goeppert B, Manns MP, Gross A, Vogel A. The BH3-only protein BID impairs the p38-mediated stress response and promotes hepatocarcinogenesis during chronic liver injury in mice. Hepatology. 2015;62(3):816-28.

Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grasser F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM. Smad7 regulates compensatory hepatocyte proliferation in damaged mouse liver and positively relates to better clinical outcome in human hepatocellular carcinoma. Clin Sci (Lond). 2015;128(11):761-74.

>De Ponti A, Wiechert L, Schneller D, Pusterla T, Longerich T, Hogg N, Vogel A, Schirmacher P, Hess J, Angel P. A pro-tumorigenic function of S100A8/A9 in carcinogen-induced hepatocellular carcinoma. Cancer Lett. 2015;369(2):396-404.

Orlik J, Schungel S, Buitrago-Molina LE, Marhenke S, Geffers R, Endig J, Lobschat K, Rossler S, Goeppert B, Manns MP, Gross A, Vogel A. The Bh3-Only Protein Bid Impairs the P38-Mediated Stress Response and Promotes Hepatocarcinogenesis During Chronic Liver Injury in Mice. Hepatology. 2015;62(3):816-28.

Mobus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-199a-5p Inhibition Enhances the Liver Repopulation Ability of Human Embryonic Stem Cell-Derived Hepatic Cells. J Hepatol. 2015;62(1):101-10.

Kirstein MM, Metzler F, Geiger E, Heinrich E, Hallensleben M, Manns MP, Vogel A. Prediction of Short- and Long-Term Outcome in Patients with Autoimmune Hepatitis. Hepatology. 2015;62(5):1524-35.

Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grasser F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM. Smad7 Regulates Compensatory Hepatocyte Proliferation in Damaged Mouse Liver and Positively Relates to Better Clinical Outcome in Human Hepatocellular Carcinoma. Clin Sci (Lond). 2015;128(11):761-74.

De Ponti A, Wiechert L, Stojanovic A, Longerich T, Marhenke S, Hogg N, Vogel A, Cerwenka A, Schirmacher P, Hess J, Angel P. Chronic Liver Inflammation and Hepatocellular Carcinogenesis Are Independent of S100a9. Int J Cancer. 2015;136(10):2458-63.

2014

Marhenke S, Buitrago-Molina LE, Endig J, Orlik J, Schweitzer N, Klett S, Longerich T, Geffers R, Sanchez Munoz A, Dorrell C, Katz SF, Lechel A, Weng H, Krech T, Lehmann U, Dooley S, Rudolph KL, Manns MP, Vogel A. P21 Promotes Sustained Liver Regeneration and Hepatocarcinogenesis in Chronic Cholestatic Liver Injury. Gut. 2014;63(9):1501-12.

2013

Yuan Q, Loya K, Rani B, Mobus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-221 Overexpression Accelerates Hepatocyte Proliferation During Liver Regeneration. Hepatology. 2013;57(1):299-310.

Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L. A Direct in Vivo Rnai Screen Identifies Mkk4 as a Key Regulator of Liver Regeneration. Cell. 2013;153(2):389-401.

Schrem H, Kurok M, Kaltenborn A, Vogel A, Walter U, Zachau L, Manns MP, Klempnauer J, Kleine M. Incidence and Long-Term Risk of De Novo Malignancies after Liver Transplantation with Implications for Prevention and Detection. Liver Transpl. 2013;19(11):1252-61.

Pusterla T, Nemeth J, Stein I, Wiechert L, Knigin D, Marhenke S, Longerich T, Kumar V, Arnold B, Vogel A, Bierhaus A, Pikarsky E, Hess J, Angel P. Receptor for Advanced Glycation Endproducts (Rage) Is a Key Regulator of Oval Cell Activation and Inflammation-Associated Liver Carcinogenesis in Mice. Hepatology. 2013;58(1):363-73. Epub 2013/03/19.

Kirstein MM, Boukouris AE, Pothiraju D, Buitrago-Molina LE, Marhenke S, Schutt J, Orlik J, Kuhnel F, Hegermann J, Manns MP, Vogel A. Activity of the Mtor Inhibitor Rad001, the Dual Mtor and Pi3-Kinase Inhibitor Bez235 and the Pi3-Kinase Inhibitor Bkm120 in Hepatocellular Carcinoma. Liver Int. 2013;33(5):780-93.

Dayoub R, Vogel A, Schuett J, Lupke M, Spieker SM, Kettern N, Hildt E, Melter M, Weiss TS. Nrf2 Activates Augmenter of Liver Regeneration (Alr) Via Antioxidant Response Element and Links Oxidative Stress to Liver Regeneration. Mol Med. 2013;19:237-44.

Buitrago-Molina LE, Marhenke S, Longerich T, Sharma AD, Boukouris AE, Geffers R, Guigas B, Manns MP, Vogel A. The Degree of Liver Injury Determines the Role of P21 in Liver Regeneration and Hepatocarcinogenesis in Mice. Hepatology. 2013;58(3):1143-52.

Breitbart A, Scharf GM, Duncker D, Widera C, Gottlieb J, Vogel A, Schmidt S, Brandes G, Heuft HG, Lichtinghagen R, Kempf T, Wollert KC, Bauersachs J, Heineke J. Highly Specific Detection of Myostatin Prodomain by an Immunoradiometric Sandwich Assay in Serum of Healthy Individuals and Patients. PLoS One. 2013;8(11):e80454.

2009

Schungel S, Buitrago-Molina LE, Nalapareddy P, Lebofsky M, Manns MP, Jaeschke H, Gross A, Vogel A. The Strength of the Fas Ligand Signal Determines Whether Hepatocytes Act as Type 1 or Type 2 Cells in Murine Livers. Hepatology. 2009;50(5):1558-66. Epub 2009/08/28.

Nalapareddy P, Schungel S, Hong JY, Manns MP, Jaeschke H, Vogel A. The Bh3-Only Protein Bid Does Not Mediate Death-Receptor-Induced Liver Injury in Obstructive Cholestasis. Am J Pathol. 2009;175(3):1077-85. Epub 2009/08/08.

Buitrago-Molina LE, Pothiraju D, Lamle J, Marhenke S, Kossatz U, Breuhahn K, Manns MP, Malek N, Vogel A. Rapamycin Delays Tumor Development in Murine Livers by Inhibiting Proliferation of Hepatocytes with DNA Damage. Hepatology. 2009;50(2):500-9.

2008

Willenbring H, Sharma AD, Vogel A, Lee AY, Rothfuss A, Wang Z, Finegold M, Grompe M. Loss of P21 Permits Carcinogenesis from Chronically Damaged Liver and Kidney Epithelial Cells Despite Unchecked Apoptosis. Cancer Cell. 2008;14(1):59-67. Epub 2008/07/05.

Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Scholer HR, Ott M. Murine Embryonic Stem Cell-Derived Hepatic Progenitor Cells Engraft in Recipient Livers with Limited Capacity of Liver Tissue Formation. Cell Transplant. 2008;17(3):313-23.

Marhenke S, Lamle J, Buitrago-Molina LE, Canon JM, Geffers R, Finegold M, Sporn M, Yamamoto M, Manns MP, Grompe M, Vogel A. Activation of Nuclear Factor E2-Related Factor 2 in Hereditary Tyrosinemia Type 1 and Its Role in Survival and Tumor Development. Hepatology. 2008;48(2):487-96. Epub 2008/07/31.

Lamle J, Marhenke S, Borlak J, von Wasielewski R, Eriksson CJ, Geffers R, Manns MP, Yamamoto M, Vogel A. Nuclear Factor-Eythroid 2-Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury. Gastroenterology. 2008;134(4):1159-68.

2006

Vogel A, Aslan JE, Willenbring H, Klein C, Finegold M, Mount H, Thomas G, Grompe M. Sustained Phosphorylation of Bid Is a Marker for Resistance to Fas-Induced Apoptosis During Chronic Liver Diseases. Gastroenterology. 2006;130(1):104-19.

2004

Vogel A, van Den Berg IE, Al-Dhalimy M, Groopman J, Ou CN, Ryabinina O, Iordanov MS, Finegold M, Grompe M. Chronic Liver Disease in Murine Hereditary Tyrosinemia Type 1 Induces Resistance to Cell Death. Hepatology. 2004;39(2):433-43. Epub 2004/02/10.

Unit 3.2 - Hepatobiliary Regeneration

2017

Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Gohring G, Schmidt H, Sgodda M, Cantz T. In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. Biol Chem. 2017.

2016

Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p mimic inhibits acute liver failure. Nature communications. 2016;7:11916.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell stem cell. 2016;18(6):797-808.

Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T. Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Cell Biol Int. 2016;40(5):534-48.

Endig J, Buitrago-Molina LE, Marhenke S, Reisinger F, Saborowski A, Schutt J, Limbourg F, Konecke C, Schreder A, Michael A, Misslitz AC, Healy ME, Geffers R, Clavel T, Haller D, Unger K, Finegold M, Weber A, Manns MP, Longerich T, Heikenwalder M, Vogel A. Dual Role of the Adaptive Immune System in Liver Injury and Hepatocellular Carcinoma Development. Cancer Cell. 2016;30(2):308-23.

Eggenschwiler R, Moslem M, Fraguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wahner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Scientific reports. 2016;6:38198.

2015

Cantz T. Die Erzeugung von Gameten aus pluripotenten Stammzellen. In: Heinemann T, Dederer H-G, Cantz T, editors. Entwicklungsbiologische Totipotenz in Ethik und Recht. Göttingen: V&R unipress; 2014. p. 57-65.

Advena-Regnery B, Böhm K, Jung B, Rottländer K, Sgodda S (2015). Sind Parthenoten Embryonen? Zur biologischen und normativen Einordnung von menschlichen Parthenoten. Zeitschrift für medizinische Ethik. 61:63-79.

Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T. Rescue of DNA-Pk Signaling and T-Cell Differentiation by Targeted Genome Editing in a Prkdc Deficient Ipsc Disease Model. PLoS Genet. 2015;11(5):e1005239.

Orlik J, Schungel S, Buitrago-Molina LE, Marhenke S, Geffers R, Endig J, Lobschat K, Rossler S, Goeppert B, Manns MP, Gross A, Vogel A. The Bh3-Only Protein Bid Impairs the P38-Mediated Stress Response and Promotes Hepatocarcinogenesis During Chronic Liver Injury in Mice. Hepatology. 2015;62(3):816-28.

Moslem M, Eberle I, Weber I, Henschler R, Cantz T. Mesenchymal Stem/Stromal Cells Derived from Induced Pluripotent Stem Cells Support Cd34(Pos) Hematopoietic Stem Cell Propagation and Suppress Inflammatory Reaction. Stem Cells Int. 2015;2015:843058. Epub 2015/07/18.

Mobus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-199a-5p Inhibition Enhances the Liver Repopulation Ability of Human Embryonic Stem Cell-Derived Hepatic Cells. J Hepatol. 2015;62(1):101-10.

Kirstein MM, Metzler F, Geiger E, Heinrich E, Hallensleben M, Manns MP, Vogel A. Prediction of Short- and Long-Term Outcome in Patients with Autoimmune Hepatitis. Hepatology. 2015;62(5):1524-35.

Kim J, Kim KP, Lim KT, Lee SC, Yoon J, Song G, Hwang SI, Scholer HR, Cantz T, Han DW. Generation of Integration-Free Induced Hepatocyte-Like Cells from Mouse Fibroblasts. Sci Rep. 2015;5:15706.

Katsirntaki K, Mauritz C, Olmer R, Schmeckebier S, Sgodda M, Puppe V, Eggenschwiler R, Duerr J, Schubert SC, Schmiedl A, Ochs M, Cantz T, Salwig I, Szibor M, Braun T, Rathert C, Martens A, Mall MA, Martin U. Bronchoalveolar Sublineage Specification of Pluripotent Stem Cells: Effect of Dexamethasone Plus Camp-Elevating Agents and Keratinocyte Growth Factor. Tissue Eng Part A. 2015;21(3-4):669-82.

Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grasser F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM. Smad7 Regulates Compensatory Hepatocyte Proliferation in Damaged Mouse Liver and Positively Relates to Better Clinical Outcome in Human Hepatocellular Carcinoma. Clin Sci (Lond). 2015;128(11):761-74.

Cantz T, Sharma AD, Ott M. Concise Review: Cell Therapies for Hereditary Metabolic Liver Diseases-Concepts, Clinical Results, and Future Developments. Stem Cells. 2015;33(4):1055-62.

2014

Marhenke S, Buitrago-Molina LE, Endig J, Orlik J, Schweitzer N, Klett S, Longerich T, Geffers R, Sanchez Munoz A, Dorrell C, Katz SF, Lechel A, Weng H, Krech T, Lehmann U, Dooley S, Rudolph KL, Manns MP, Vogel A. P21 Promotes Sustained Liver Regeneration and Hepatocarcinogenesis in Chronic Cholestatic Liver Injury. Gut. 2014;63(9):1501-12.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

2013

Yuan Q, Loya K, Rani B, Mobus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-221 Overexpression Accelerates Hepatocyte Proliferation During Liver Regeneration. Hepatology. 2013;57(1):299-310.

Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L. A Direct in Vivo Rnai Screen Identifies Mkk4 as a Key Regulator of Liver Regeneration. Cell. 2013;153(2):389-401.

Sgodda M, Mobus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T. Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells. Curr Mol Med. 2013;13(5):842-55.

Sgodda M, Cantz T. Small but Significant: Inter- and Intrapatient Variations in Ips Cell-Based Disease Modeling. Mol Ther. 2013;21(1):5-7. Epub 2013/01/03.

Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U. Keratinocyte Growth Factor and Dexamethasone Plus Elevated Camp Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type Ii Cells. Tissue Engineering Part A. 2013;19(7-8):938-51.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. A Ubiquitous Chromatin Opening Element Prevents Transgene Silencing in Pluripotent Stem Cells and Their Differentiated Progeny. Stem Cells. 2013;31(3):488-99.

Pfaff N, Cantz T. From Skin to Blood: A New Member Joins the Iclub. Cell Stem Cell. 2013;13(2):131-3.

Gross B, Sgodda M, Rasche M, Schambach A, Gohring G, Schlegelberger B, Greber B, Linden T, Reinhardt D, Cantz T, Klusmann JH. Improved Generation of Patient-Specific Induced Pluripotent Stem Cells Using a Chemically-Defined and Matrigel-Based Approach. Curr Mol Med. 2013;13(5):765-76.

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med. 2013;2(9):641-54.

Dayoub R, Vogel A, Schuett J, Lupke M, Spieker SM, Kettern N, Hildt E, Melter M, Weiss TS. Nrf2 Activates Augmenter of Liver Regeneration (Alr) Via Antioxidant Response Element and Links Oxidative Stress to Liver Regeneration. Mol Med. 2013;19:237-44.

Buitrago-Molina LE, Marhenke S, Longerich T, Sharma AD, Boukouris AE, Geffers R, Guigas B, Manns MP, Vogel A. The Degree of Liver Injury Determines the Role of P21 in Liver Regeneration and Hepatocarcinogenesis in Mice. Hepatology. 2013;58(3):1143-52.

Publications of the former Research Unit Liver Regeneration (2007-2012)

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL. A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage. Cell. 2012;148(5):1001-14.

Liu L, Ulbrich J, Muller J, Wustefeld T, Aeberhard L, Kress TR, Muthalagu N, Rycak L, Rudalska R, Moll R, Kempa S, Zender L, Eilers M, Murphy DJ. Deregulated Myc Expression Induces Dependence Upon Ampk-Related Kinase 5. Nature. 2012;483(7391):608-12.

Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L. Senescence Surveillance of Pre-Malignant Hepatocytes Limits Liver Cancer Development. Nature. 2011;479(7374):547-51.

Zender L, Villanueva A, Tovar V, Sia D, Chiang DY, Llovet JM. Cancer Gene Discovery in Hepatocellular Carcinoma. J Hepatol. 2010;52(6):921-9.

Wuestefeld T, Zender L. Dlc1 and Liver Cancer: The Akt Connection. Gastroenterology. 2010;139(4):1093-6.

Kühnel F, Gürlevik E, Wirth TC, Strüver N, Malek NP, Müller-Schilling M, Manns MP, Carnero A, Zender L, Kubicka S. Targeting of P53-Transcriptional Dysfunction by Conditionally Replicating Adenovirus Is Not Limited by P53-Homologues. Molecular Therapy. 2010;18(5):936-46.

Gurlevik E, Woller N, Struver N, Schache P, Kloos A, Manns MP, Zender L, Kuhnel F, Kubicka S. Selectivity of Oncolytic Viral Replication Prevents Antiviral Immune Response and Toxicity, but Does Not Improve Antitumoral Immunity. Mol Ther. 2010;18(11):1972-82.

Zender L, Rudolph KL. Keeping Your Senescent Cells under Control. Aging (Albany NY). 2009;1(5):438-41.

Xu MZ, Yao TJ, Lee NP, Ng IO, Chan YT, Zender L, Lowe SW, Poon RT, Luk JM. Yes-Associated Protein Is an Independent Prognostic Marker in Hepatocellular Carcinoma. Cancer. 2009;115(19):4576-85. Epub 2009/06/25.

Schache P, Gurlevik E, Struver N, Woller N, Malek N, Zender L, Manns M, Wirth T, Kuhnel F, Kubicka S. Vsv Virotherapy Improves Chemotherapy by Triggering Apoptosis Due to Proteasomal Degradation of Mcl-1. Gene Ther. 2009;16(7):849-61. Epub 2009/04/17.

Ma O, Cai WW, Zender L, Dayaram T, Shen J, Herron AJ, Lowe SW, Man TK, Lau CC, Donehower LA. Mmp13, Birc2 (Ciap1), and Birc3 (Ciap2), Amplified on Chromosome 9, Collaborate with P53 Deficiency in Mouse Osteosarcoma Progression. Cancer Res. 2009;69(6):2559-67.

Liu LX, Lee NP, Chan VW, Xue W, Zender L, Zhang C, Mao M, Dai H, Wang XL, Xu MZ, Lee TK, Ng IO, Chen Y, Kung HF, Lowe SW, Poon RT, Wang JH, Luk JM. Targeting Cadherin-17 Inactivates Wnt Signaling and Inhibits Tumor Growth in Liver Carcinoma. Hepatology. 2009;50(5):1453-63.

Laska MJ, Lowe SW, Zender L, Hearn S, Vogel U, Jensen UB, Bric A, Nexo BA. Enforced Expression of Ppp1r13l Increases Tumorigenesis and Invasion through P53-Dependent and P53-Independent Mechanisms. Mol Carcinog. 2009;48(9):832-42. Epub 2009/03/06.

Gurlevik E, Woller N, Schache P, Malek NP, Wirth TC, Zender L, Manns MP, Kubicka S, Kuhnel F. P53-Dependent Antiviral Rna-Interference Facilitates Tumor-Selective Viral Replication. Nucleic Acids Res. 2009;37(12):e84.

Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. Functional Identification of Tumor-Suppressor Genes through an in Vivo Rna Interference Screen in a Mouse Lymphoma Model. Cancer Cell. 2009;16(4):324-35. Epub 2009/10/06.

Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, Lowe SW. An Oncogenomics-Based in Vivo Rnai Screen Identifies Tumor Suppressors in Liver Cancer. Cell. 2008;135(5):852-64.

Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. Dlc1 Is a Chromosome 8p Tumor Suppressor Whose Loss Promotes Hepatocellular Carcinoma. Genes Dev. 2008;22(11):1439-44. Epub 2008/06/04.

Krizhanovsky V, Yon M, Dickins RA, Hearn S, Simon J, Miething C, Yee H, Zender L, Lowe SW. Senescence of Activated Stellate Cells Limits Liver Fibrosis. Cell. 2008;134(4):657-67.

Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, Rudolph C, Kuhnel F, Wei K, Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice. Cell. 2007;130(5):863-77.

Unit 3.3 - miRNA in Liver Regeneration

2016

Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p mimic inhibits acute liver failure. Nature communications. 2016;7:11916.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell stem cell. 2016;18(6):797-808.

Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, Adachi K, Jang YJ, Kim J, Oh KJ, Kwak TH, Hwang SI, You JS, Ko K, Koo SH, Sharma AD, Kim JH, Hui L, Cantz T, Scholer HR, Han DW. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell reports. 2016.

Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-125b-5p Mimic Inhibits Acute Liver Failure. Nat Commun. 2016;7:11916. Epub 2016/06/24.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes in Vivo Attenuates Liver Fibrosis. Cell Stem Cell. 2016;18(6):797-808. Epub 2016/03/01.

Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, Adachi K, Jang YJ, Kim J, Oh KJ, Kwak TH, Hwang SI, You JS, Ko K, Koo SH, Sharma AD, Kim JH, Hui L, Cantz T, Scholer HR, Han DW. Small Molecules Facilitate Single Factor-Mediated Hepatic Reprogramming. Cell Rep. 2016. Epub 2016/05/07.

2015

Mattis AN, Song G, Hitchner K, Kim RY, Lee AY, Sharma AD, Malato Y, McManus MT, Esau CC, Koller E, Koliwad S, Lim LP, Maher JJ, Raffai RL, Willenbring H. A Screen in Mice Uncovers Repression of Lipoprotein Lipase by Microrna-29a as a Mechanism for Lipid Distribution Away from the Liver. Hepatology. 2015;61(1):141-52. Epub 2014/08/19.

2014

Möbus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-199a-5p Inhibition Enhances the Liver Repopulation Ability of Human Embryonic Stem Cell-Derived Hepatic Cells. J Hepatol. 2015;62(1):101-10. Epub 2014/08/20.

Cantz T, Sharma AD, Ott M. Concise Review: Cell Therapies for Hereditary Metabolic Liver Diseases - Concepts, Clinical Results and Future Developments. Stem Cells. 2014. Epub 2014/12/20.

2013

Buitrago-Molina LE, Marhenke S, Longerich T, Sharma AD, Boukouris AE, Geffers R, Guigas B, Manns MP, Vogel A. The Degree of Liver Injury Determines the Role of P21 in Liver Regeneration and Hepatocarcinogenesis in Mice. Hepatology. 2013;58(3):1143-52. Epub 2013/03/26.

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med. 2013;2(9):641-54. Epub 2013/08/09.

Sgodda M, Möbus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T. Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells. Curr Mol Med. 2013;13(5):842-55. Epub 2013/05/07.

Yuan Q, Loya K, Rani B, Möbus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-221 Overexpression Accelerates Hepatocyte Proliferation During Liver Regeneration. Hepatology. 2013;57(1):299-310. Epub 2012/07/24.

2011

Sharma AD, Narain N, Handel EM, Iken M, Singhal N, Cathomen T, Manns MP, Scholer HR, Ott M, Cantz T. MicroRNA-221 regulates FAS-induced fulminant liver failure. Hepatology. 2011;53(5):1651-61. Epub 2011/03/15.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T. Generation of healthy mice from gene-corrected disease-specific induced pluripotent stem cells. PLoS Biol. 2011;9(7):e1001099. Epub 2011/07/19.

Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, Verdin E. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY). 2010;2(7):415-31. Epub 2010/07/17.

Song G, Sharma AD, Roll GR, Ng R, Lee AY, Blelloch RH, Frandsen NM, Willenbring H. MicroRNAs control hepatocyte proliferation during liver regeneration. Hepatology. 2010;51(5):1735-43. Epub 2010/05/01.

Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Scholer HR, Ott M. Murine embryonic stem cell-derived hepatic progenitor cells engraft in recipient livers with limited capacity of liver tissue formation. Cell Transplant. 2008;17(3):313-23.

Willenbring H, Sharma AD, Vogel A, Lee AY, Rothfuss A, Wang Z, Finegold M, Grompe M. Loss of p21 permits carcinogenesis from chronically damaged liver and kidney epithelial cells despite unchecked apoptosis. Cancer Cell. 2008;14(1):59-67. Epub 2008/07/05.

Jochheim-Richter A, Rudrich U, Koczan D, Hillemann T, Tewes S, Petry M, Kispert A, Sharma AD, Attaran F, Manns MP, Ott M. Gene expression analysis identifies novel genes participating in early murine liver development and adult liver regeneration. Differentiation. 2006;74(4):167-73. Epub 2006/05/11.

Sharma AD, Cantz T, Manns MP, Ott M. The role of stem cells in physiology, pathophysiology, and therapy of the liver. Stem Cell Rev. 2006;2(1):51-8. Epub 2006/12/05.

Sharma AD, Cantz T, Richter R, Eckert K, Henschler R, Wilkens L, Jochheim-Richter A, Arseniev L, Ott M. Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am J Pathol. 2005;167(2):555-64. Epub 2005/07/29.

Cantz T, Sharma AD, Jochheim-Richter A, Arseniev L, Klein C, Manns MP, Ott M. Reevaluation of bone marrow-derived cells as a source for hepatocyte regeneration. Cell Transplantation. 2004;13(6):659-66. Epub 2005/01/15.

Unit 3.4 - Hepatic Cell Therapy - Patient Liver Stem Cells

2015

Goldhafer F, Bock M, Falk CS, Vondran FWR. Immunological Aspects of Liver Cell Transplantation. World Journal of Transplantation. 2015.

Colleypriest BJ, Burke ZD, Leonard P, Griffiths LP, Chen Y, Yu W-Y, Jover R, Bock M, Biddlestone L, Quinlan JM, Ward SG, Farrant JM, Slack JMW, Tosh D. Hnf4α is a master gene that can generate columnar metaplasia in oesophageal epithelium. 2015.

2014

Taranta A, Rogalska-Taranta M, Gutierrez R, Manns MP, Bock M, Wursthorn K. Rapid Hepatitis B and Hepatitis Delta Virus Rna Quantification from Small-Sized Liver Tissue Samples. J Clin Virol. 2014;61(2):286-8.

Riedel G, Rudrich U, Fekete-Drimusz N, Manns MP, Vondran FW, Bock M. An Extended Deltact-Method Facilitating Normalisation with Multiple Reference Genes Suited for Quantitative Rt-Pcr Analyses of Human Hepatocyte-Like Cells. PLoS One. 2014;9(3):e93031.

2012

Waern JM, Yuan Q, Rudrich U, Becker PD, Schulze K, Strick-Marchand H, Huntington ND, Zacher BJ, Wursthorn K, DiSanto JP, Guzman CA, Manns MP, Ott M, Bock M. Ectopic Expression of Murine Cd47 Minimizes Macrophage Rejection of Human Hepatocyte Xenografts in Immunodeficient Mice. Hepatology. 2012;56(4):1479-88.

Rothe M, Rittelmeyer I, Iken M, Rudrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U. Epidermal Growth Factor Improves Lentivirus Vector Gene Transfer into Primary Mouse Hepatocytes. Gene Ther. 2012;19(4):425-34. Epub 2011/08/19.

2011

Iacob R, Rudrich U, Rothe M, Kirsch S, Maasoumy B, Narain N, Verfaillie CM, Sancho-Bru P, Iken M, Popescu I, Schambach A, Manns MP, Bock M. Induction of a Mature Hepatocyte Phenotype in Adult Liver Derived Progenitor Cells by Ectopic Expression of Transcription Factors. Stem Cell Res. 2011;6(3):251-61.

2009

Sancho-Bru P, Najimi M, Caruso M, Pauwelyn K, Cantz T, Forbes S, Roskams T, Ott M, Gehling U, Sokal E, Verfaillie CM, Muraca M. Stem and Progenitor Cells for Liver Repopulation: Can We Standardise the Process from Bench to Bedside? Gut. 2009;58(4):594-603. Epub 2008/12/19.

Meyburg J, Das AM, Hoerster F, Lindner M, Kriegbaum H, Engelmann G, Schmidt J, Ott M, Pettenazzo A, Luecke T, Bertram H, Hoffmann GF, Burlina A. One Liver for Four Children: First Clinical Series of Liver Cell Transplantation for Severe Neonatal Urea Cycle Defects. Transplantation. 2009;87(5):636-41.

Haridass D, Yuan Q, Becker PD, Cantz T, Iken M, Rothe M, Narain N, Bock M, Norder M, Legrand N, Wedemeyer H, Weijer K, Spits H, Manns MP, Cai J, Deng H, Di Santo JP, Guzman CA, Ott M. Repopulation Efficiencies of Adult Hepatocytes, Fetal Liver Progenitor Cells, and Embryonic Stem Cell-Derived Hepatic Cells in Albumin-Promoter-Enhancer Urokinase-Type Plasminogen Activator Mice. Am J Pathol. 2009;175(4):1483-92.

2008

Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Scholer HR, Ott M. Murine Embryonic Stem Cell-Derived Hepatic Progenitor Cells Engraft in Recipient Livers with Limited Capacity of Liver Tissue Formation. Cell Transplant. 2008;17(3):313-23.

2006

Jochheim-Richter A, Rudrich U, Koczan D, Hillemann T, Tewes S, Petry M, Kispert A, Sharma AD, Attaran F, Manns MP, Ott M. Gene Expression Analysis Identifies Novel Genes Participating in Early Murine Liver Development and Adult Liver Regeneration. Differentiation. 2006;74(4):167-73.

Unit 3.5 - Hepatic Cell Transplantation and Genetic Manipulation

2016

Yang D, Yuan Q, Balakrishnan A, Bantel H, Klusmann JH, Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p mimic inhibits acute liver failure. Nature communications. 2016;7:11916.

Wang LL, Balakrishnan A, Bigall NC, Candito D, Miethe JF, Seidel K, Xie Y, Ott M, Kirschning A. A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for Use in Magnetic Drug Targeting. Chemistry. 2016.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell stem cell. 2016;18(6):797-808.

Hubner J, Hoseini SS, Suerth JD, Hoffmann D, Maluski M, Herbst J, Maul H, Ghosh A, Eiz-Vesper B, Yuan Q, Ott M, Heuser M, Schambach A, Sauer MG. Generation of Genetically Engineered Precursor T-Cells From Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform. Molecular therapy : the journal of the American Society of Gene Therapy. 2016;24(7):1216-26.

2015

Mobus S, Yang D, Yuan Q, Ludtke TH, Balakrishnan A, Sgodda M, Rani B, Kispert A, Arauzo-Bravo MJ, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-199a-5p Inhibition Enhances the Liver Repopulation Ability of Human Embryonic Stem Cell-Derived Hepatic Cells. J Hepatol. 2015;62(1):101-10.

Junge N, Mingozzi F, Ott M, Baumann U. Adeno-Associated Virus Vector-Based Gene Therapy for Monogenetic Metabolic Diseases of the Liver. J Pediatr Gastroenterol Nutr. 2015;60(4):433-40.

Cantz T, Sharma AD, Ott M. Concise Review: Cell Therapies for Hereditary Metabolic Liver Diseases-Concepts, Clinical Results, and Future Developments. Stem Cells. 2015;33(4):1055-62.

2014

Ott M, Cantz T, Schneider A, Manns MP. [Diagnosis and Therapies for Acute Liver Failure: Scientific Developments]. Internist (Berl). 2014;55(11):1288-95. Diagnostik und Behandlung des akuten Leberversagens: Wissenschaftliche Entwicklungen.

Berneman-Zeitouni D, Molakandov K, Elgart M, Mor E, Fornoni A, Dominguez MR, Kerr-Conte J, Ott M, Meivar-Levy I, Ferber S. The Temporal and Hierarchical Control of Transcription Factors-Induced Liver to Pancreas Transdifferentiation. PLoS One. 2014;9(2):e87812.

Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E. Turmeric Curcumin Inhibits Entry of All Hepatitis C Virus Genotypes into Human Liver Cells. Gut. 2014;63(7):1137-49. Epub 2013/08/02.

2013

Yuan Q, Loya K, Rani B, Mobus S, Balakrishnan A, Lamle J, Cathomen T, Vogel A, Manns MP, Ott M, Cantz T, Sharma AD. Microrna-221 Overexpression Accelerates Hepatocyte Proliferation During Liver Regeneration. Hepatology. 2013;57(1):299-310.

Wuestefeld T, Pesic M, Rudalska R, Dauch D, Longerich T, Kang TW, Yevsa T, Heinzmann F, Hoenicke L, Hohmeyer A, Potapova A, Rittelmeier I, Jarek M, Geffers R, Scharfe M, Klawonn F, Schirmacher P, Malek NP, Ott M, Nordheim A, Vogel A, Manns MP, Zender L. A Direct in Vivo Rnai Screen Identifies Mkk4 as a Key Regulator of Liver Regeneration. Cell. 2013;153(2):389-401. Epub 2013/04/16.

Sgodda M, Mobus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T. Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells. Curr Mol Med. 2013;13(5):842-55.

Rittelmeyer I, Rothe M, Brugman MH, Iken M, Schambach A, Manns MP, Baum C, Modlich U, Ott M. Hepatic Lentiviral Gene Transfer Is Associated with Clonal Selection, but Not with Tumor Formation in Serially Transplanted Rodents. Hepatology. 2013;58(1):397-408.

Norenberg A, Heinz S, Scheller K, Hewitt NJ, Braspenning J, Ott M. Optimization of Upcyte(R) Human Hepatocytes for the in Vitro Micronucleus Assay. Mutat Res. 2013;758(1-2):69-79.

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med. 2013;2(9):641-54. Epub 2013/08/09.

Abel T, El Filali E, Waern J, Schneider IC, Yuan Q, Munch RC, Hick M, Warnecke G, Madrahimov N, Kontermann RE, Schuttrumpf J, Muller UC, Seppen J, Ott M, Buchholz CJ. Specific Gene Delivery to Liver Sinusoidal and Artery Endothelial Cells. Blood. 2013;122(12):2030-8.

2012

Waern JM, Yuan Q, Rudrich U, Becker PD, Schulze K, Strick-Marchand H, Huntington ND, Zacher BJ, Wursthorn K, DiSanto JP, Guzman CA, Manns MP, Ott M, Bock M. Ectopic Expression of Murine Cd47 Minimizes Macrophage Rejection of Human Hepatocyte Xenografts in Immunodeficient Mice. Hepatology. 2012;56(4):1479-88.

Rothe M, Rittelmeyer I, Iken M, Rudrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U. Epidermal Growth Factor Improves Lentivirus Vector Gene Transfer into Primary Mouse Hepatocytes. Gene Ther. 2012;19(4):425-34. Epub 2011/08/19.

Kafert-Kasting S, Schneider A, Attaran M, Priesner C, Barthold M, Perrier AL, Kriegbaum H, Ott M, Meyburg J. Safety Assessment of Intraportal Liver Cell Application in New Zealand White Rabbits under Glp Conditions. Arch Toxicol. 2012;86(9):1413-22.

Bieback K, Wuchter P, Besser D, Franke W, Becker M, Ott M, Pacher M, Ma N, Stamm C, Kluter H, Muller A, Ho AD, consortium S-M. Mesenchymal Stromal Cells (Mscs): Science and F(R)Iction. J Mol Med (Berl). 2012;90(7):773-82.

2011

Straub BK, Rickelt S, Zimbelmann R, Grund C, Kuhn C, Iken M, Ott M, Schirmacher P, Franke WW. E-N-Cadherin Heterodimers Define Novel Adherens Junctions Connecting Endoderm-Derived Cells. J Cell Biol. 2011;195(5):873-87. Epub 2011/11/23.

Sharma AD, Narain N, Handel EM, Iken M, Singhal N, Cathomen T, Manns MP, Scholer HR, Ott M, Cantz T. Microrna-221 Regulates Fas-Induced Fulminant Liver Failure. Hepatology. 2011;53(5):1651-61.

Sancho-Bru P, Roelandt P, Narain N, Pauwelyn K, Notelaers T, Shimizu T, Ott M, Verfaillie C. Directed Differentiation of Murine-Induced Pluripotent Stem Cells to Functional Hepatocyte-Like Cells. J Hepatol. 2011;54(1):98-107.

Koenig S, Yuan Q, Krause P, Christiansen H, Rave-Fraenk M, Kafert-Kasting S, Kriegbaum H, Schneider A, Ott M, Meyburg J. Regional Transient Portal Ischemia and Irradiation as Preparative Regimen for Hepatocyte Transplantation. Cell Transplant. 2011;20(2):303-11. Epub 2010/08/20.

Kang TW, Yevsa T, Woller N, Hoenicke L, Wuestefeld T, Dauch D, Hohmeyer A, Gereke M, Rudalska R, Potapova A, Iken M, Vucur M, Weiss S, Heikenwalder M, Khan S, Gil J, Bruder D, Manns M, Schirmacher P, Tacke F, Ott M, Luedde T, Longerich T, Kubicka S, Zender L. Senescence Surveillance of Pre-Malignant Hepatocytes Limits Liver Cancer Development. Nature. 2011;479(7374):547-51. Epub 2011/11/15.

Iacob R, Rudrich U, Rothe M, Kirsch S, Maasoumy B, Narain N, Verfaillie CM, Sancho-Bru P, Iken M, Popescu I, Schambach A, Manns MP, Bock M. Induction of a Mature Hepatocyte Phenotype in Adult Liver Derived Progenitor Cells by Ectopic Expression of Transcription Factors. Stem Cell Res. 2011;6(3):251-61.

Ciesek S, von Hahn T, Colpitts CC, Schang LM, Friesland M, Steinmann J, Manns MP, Ott M, Wedemeyer H, Meuleman P, Pietschmann T, Steinmann E. The Green Tea Polyphenol, Epigallocatechin-3-Gallate, Inhibits Hepatitis C Virus Entry. Hepatology. 2011;54(6):1947-55.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011;9(7):e1001099.

Unit 4.1- Biohybrid Lung

2017

Pflaum M, Kühn-Kauffeldt M, Schmeckebier S, Dipresa D, Chauhan K, Wiegmann B, Haug RJ, Schein J, Haverich A, Korossis S. Endothelialization and characterization of titanium dioxide-coated gas-exchange membranes for application in the bioartificial lung. Acta biomaterialia. 2017;50:510-21.

2016

Wiegmann B, von Seggern H, Hoffler K, Korossis S, Dipresa D, Pflaum M, Schmeckebier S, Seume J, Haverich A. Developing a biohybrid lung - sufficient endothelialization of poly-4-methly-1-pentene gas exchange hollow-fiber membranes. J Mech Behav Biomed Mater. 2016;60:301-11.

Theodoridis K, Muller J, Ramm R, Findeisen K, Andree B, Korossis S, Haverich A, Hilfiker A. Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves. Acta biomaterialia. 2016;43:71-7.

Roberts N, Morticelli L, Jin Z, Ingham E, Korossis S. Regional biomechanical and histological characterization of the mitral valve apparatus: Implications for mitral repair strategies. J Biomech. 2016;49(12):2491-501.

Marino M, Korossis S. Cardiovascular biomechanics in health and disease. Journal of Biomechanics. 2016;49(12):2319-20.

Joda A, Jin Z, Haverich A, Summers J, Korossis S. Multiphysics simulation of the effect of leaflet thickness inhomogeneity and material anisotropy on the stress-strain distribution on the aortic valve. J Biomech. 2016;49(12):2502-12.

2015

Alexandros R, Wolkers WF, Oleksandr G, Panagiotis K, Marc M, Holger Z, Sotirios K, Birgit G. - Coaxial Electrospinning as a Process to Engineer Biodegradable Polymeric. 2015

Katsimpoulas M, Morticelli L, Michalopoulos E, Gontika I, Stavropoulos-Giokas C, Kostakis A, Haverich A, Korossis S. Investigation of the Biomechanical Integrity of Decellularized Rat Abdominal Aorta. Transplant Proc. 2015;47(4):1228-33.

Paniagua Gutierrez JR, Berry H, Korossis S, Mirsadraee S, Lopes SV, da Costa F, Kearney J, Watterson K, Fisher J, Ingham E. Regenerative Potential of Low-Concentration Sds-Decellularized Porcine Aortic Valved Conduits in Vivo. Tissue Eng Part A. 2015;21(1-2):332-42.

Wiegmann B, Korossis S, Burgwitz K, Hurschler C, Fischer S, Haverich A, Kuehn C. In Vitro Comparison of Biological and Synthetic Materials for Skeletal Chest Wall Reconstruction. Ann Thorac Surg. 2015;99(3):991-8.

Sommer W, Marsch G, Kaufeld T, Rontgen P, Beutel G, Tongers J, Warnecke G, Tudorache I, Schieffer B, Haverich A, Kuhn C. Cardiac Awake Extracorporeal Life Support-Bridge to Decision? Artif Organs. 2015;39(5):400-8.

Tudorache I, Sommer W, Kuhn C, Wiesner O, Hadem J, Fuhner T, Ius F, Avsar M, Schwerk N, Bothig D, Gottlieb J, Welte T, Bara C, Haverich A, Hoeper MM, Warnecke G. Lung Transplantation for Severe Pulmonary Hypertension--Awake Extracorporeal Membrane Oxygenation for Postoperative Left Ventricular Remodelling. Transplantation. 2015;99(2):451-8.

Iablonskii P, Cebotari S, Tudorache I, Granados M, Morticelli L, Goecke T, Klein N, Korossis S, Hilfiker A, Haverich A. Tissue-Engineered Mitral Valve: Morphology and Biomechanics Dagger. Interact Cardiovasc Thorac Surg. 2015;20(6):712-9; discussion 9.

Ius F, Sommer W, Tudorache I, Avsar M, Siemeni T, Salman J, Puntigam J, Optenhoefel J, Greer M, Welte T, Wiesner O, Haverich A, Hoeper M, Kuehn C, Warnecke G. Veno-Veno-Arterial Extracorporeal Membrane Oxygenation for Respiratory Failure with Severe Haemodynamic Impairment: Technique and Early Outcomes. Interact Cardiovasc Thorac Surg. 2015;20(6):761-7.

Mohrmann C, Herold C, Pflaum M, Kramer R, Vogt PM, Allert S. [Viability and Particle Size of Fat Grafts Obtained with Wal and Pal Techniques]. Handchir Mikrochir Plast Chir. 2015;47(4):246-52. Epub 2015/08/20. Vitalitat und Partikelgrosse bei der autologen Fetttransplantation mit der WAL und der PAL Technik.

2014

Wiegmann B, Figueiredo C, Gras C, Pflaum M, Schmeckebier S, Korossis S, Haverich A, Blasczyk R. Prevention of Rejection of Allogeneic Endothelial Cells in a Biohybrid Lung by Silencing Hla-Class I Expression. Biomaterials. 2014;35(28):8123-33.

Luo J, Korossis SA, Wilshaw SP, Jennings LM, Fisher J, Ingham E. Development and Characterization of Acellular Porcine Pulmonary Valve Scaffolds for Tissue Engineering. Tissue Eng Part A. 2014;20(21-22):2963-74.

Hess C, Schwenke A, Wagener P, Franzka S, Laszlo Sajti C, Pflaum M, Wiegmann B, Haverich A, Barcikowski S. Dose-Dependent Surface Endothelialization and Biocompatibility of Polyurethane Noble Metal Nanocomposites. J Biomed Mater Res A. 2014;102(6):1909-20.

2013

Wiegmann B, Maurer A, Zhang R, Zardo P, Haverich A, Fischer S. Combined Pulmonary and Renal Support in a Single Extracorporeal Device. ASAIO J. 2013;59(4):433-8.

Morticelli L, Thomas D, Roberts N, Ingham E, Korossis S. Investigation of the Suitability of Decellularized Porcine Pericardium in Mitral Valve Reconstruction. J Heart Valve Dis. 2013;22(3):340-53. Epub 2013/10/25.

Riches K, Angelini TG, Mudhar GS, Kaye J, Clark E, Bailey MA, Sohrabi S, Korossis S, Walker PG, Scott DJ, Porter KE. Exploring Smooth Muscle Phenotype and Function in a Bioreactor Model of Abdominal Aortic Aneurysm. J Transl Med. 2013;11:208.

Hoeper MM, Wiesner O, Hadem J, Wahl O, Suhling H, Duesberg C, Sommer W, Warnecke G, Greer M, Boenisch O, Busch M, Kielstein JT, Schneider A, Haverich A, Welte T, Kuhn C. Extracorporeal Membrane Oxygenation Instead of Invasive Mechanical Ventilation in Patients with Acute Respiratory Distress Syndrome. Intensive Care Med. 2013;39(11):2056-7.

Moller L, Hess C, Palecek J, Su Y, Haverich A, Kirschning A, Drager G. Towards a Biocompatible Artificial Lung: Covalent Functionalization of Poly(4-Methylpent-1-Ene) (Tpx) with Crgd Pentapeptide. Beilstein J Org Chem. 2013;9:270-7.

2012

Kauffeldt M, Pflaum M, Pietzka M, Wiegmann B, Schein J, Haverich A. Triggerless pulsed vacuum arc plasma deposition of thin TiO2 coatings on Polymethylpenten foils as a functional coating for medical applications. Discharges and Electrical Insulation in Vacuum (ISDEIV). accepted for publication. 2012.

Beisswenger C, Hess C, Bals R. Aspergillus Fumigatus Conidia Induce Interferon-Beta Signalling in Respiratory Epithelial Cells. Eur Respir J. 2012;39(2):411-8.

Warnecke G, Moradiellos J, Tudorache I, Kuhn C, Avsar M, Wiegmann B, Sommer W, Ius F, Kunze C, Gottlieb J, Varela A, Haverich A. Normothermic Perfusion of Donor Lungs for Preservation and Assessment with the Organ Care System Lung before Bilateral Transplantation: A Pilot Study of 12 Patients. Lancet. 2012;380(9856):1851-8.

Michalopoulos E, Knight RL, Korossis S, Kearney JN, Fisher J, Ingham E. Development of Methods for Studying the Differentiation of Human Mesenchymal Stem Cells under Cyclic Compressive Strain. Tissue Eng Part C Methods. 2012;18(4):252-62.

Zhang R, Mietchen C, Kruger M, Wiegmann B, Golpon H, Dettmer S, Haverich A, Zardo P. Endobronchial Ultrasound Guided Fine Needle Aspiration Versus Transcervical Mediastinoscopy in Nodal Staging of Non Small Cell Lung Cancer: A Prospective Comparison Study. J Cardiothorac Surg. 2012;7:51.

Ius F, Kuehn C, Tudorache I, Sommer W, Avsar M, Boethig D, Fuehner T, Gottlieb J, Hoeper M, Haverich A, Warnecke G. Lung Transplantation on Cardiopulmonary Support: Venoarterial Extracorporeal Membrane Oxygenation Outperformed Cardiopulmonary Bypass. J Thorac Cardiovasc Surg. 2012;144(6):1510-6.

Fuehner T, Kuehn C, Hadem J, Wiesner O, Gottlieb J, Tudorache I, Olsson KM, Greer M, Sommer W, Welte T, Haverich A, Hoeper MM, Warnecke G. Extracorporeal Membrane Oxygenation in Awake Patients as Bridge to Lung Transplantation. Am J Respir Crit Care Med. 2012;185(7):763-8. Epub 2012/01/24.

Zhang R, Wiegmann B, Fischer S, Dickgreber NJ, Hagl C, Kruger M, Haverich A, Zardo P. Simultaneous Cardiac and Lung Surgery for Incidental Solitary Pulmonary Nodule: Learning from the Past. Thorac Cardiovasc Surg. 2012;60(2):150-5.

Olmer R, Lange A, Selzer S, Kasper C, Haverich A, Martin U, Zweigerdt R. Suspension Culture of Human Pluripotent Stem Cells in Controlled, Stirred Bioreactors. Tissue Eng Part C Methods. 2012;18(10):772-84.

2011

Zardo P, Zhang R, Wiegmann B, Haverich A, Fischer S. Biological Materials for Diaphragmatic Repair: Initial Experiences with the Periguard Repair Patch(R). Thorac Cardiovasc Surg. 2011;59(1):40-4.

Kuhn C, Disque C, Muhl H, Orszag P, Stiesch M, Haverich A. Evaluation of Commercial Universal Rrna Gene Pcr Plus Sequencing Tests for Identification of Bacteria and Fungi Associated with Infectious Endocarditis. J Clin Microbiol. 2011;49(8):2919-23.

Gruene M, Pflaum M, Deiwick A, Koch L, Schlie S, Unger C, Wilhelmi M, Haverich A, Chichkov BN. Adipogenic Differentiation of Laser-Printed 3d Tissue Grafts Consisting of Human Adipose-Derived Stem Cells. Biofabrication. 2011;3(1):015005.

Gruene M, Pflaum M, Hess C, Diamantouros S, Schlie S, Deiwick A, Koch L, Wilhelmi M, Jockenhoevel S, Haverich A, Chichkov B. Laser Printing of Three-Dimensional Multicellular Arrays for Studies of Cell-Cell and Cell-Environment Interactions. Tissue Eng Part C Methods. 2011;17(10):973-82.

Bisdas T, Beutel G, Warnecke G, Hoeper MM, Kuehn C, Haverich A, Teebken OE. Vascular Complications in Patients Undergoing Femoral Cannulation for Extracorporeal Membrane Oxygenation Support. Ann Thorac Surg. 2011;92(2):626-31.

Martens A, Gruh I, Dimitroulis D, Rojas SV, Schmidt-Richter I, Rathert C, Khaladj N, Gawol A, Chikobava MG, Martin U, Haverich A, Kutschka I. Rhesus Monkey Cardiosphere-Derived Cells for Myocardial Restoration. Cytotherapy. 2011;13(7):864-72.

Zweigerdt R, Olmer R, Singh H, Haverich A, Martin U. Scalable Expansion of Human Pluripotent Stem Cells in Suspension Culture. Nat Protoc. 2011;6(5):689-700.

Beutel G, Wiesner O, Eder M, Hafer C, Schneider AS, Kielstein JT, Kühn C, Heim A, Ganzenmüller T, Kreipe H-H, Haverich A, Tecklenburg A, Ganser A, Welte T, Hoeper MM. Virus-Associated Hemophagocytic Syndrome as a Major Contributor to Death in Patients with 2009 Influenza a (H1n1) Infection. Critical Care. 2011;15(2):R80-R.

2010

Hess C, Herr C, Beisswenger C, Zakharkina T, Schmid RM, Bals R. Myeloid Rela Regulates Pulmonary Host Defense Networks. Eur Respir J. 2010;35(2):343-52.

Hess C, Wiegmann B, Maurer AN, Fischer P, Moller L, Martin U, Hilfiker A, Haverich A, Fischer S. Reduced Thrombocyte Adhesion to Endothelialized Poly 4-Methyl-1-Pentene Gas Exchange Membranes-a First Step toward Bioartificial Lung Development. Tissue Eng Part A. 2010;16(10):3043-53.

Olsson KM, Simon A, Strueber M, Hadem J, Wiesner O, Gottlieb J, Fuehner T, Fischer S, Warnecke G, Kuhn C, Haverich A, Welte T, Hoeper MM. Extracorporeal Membrane Oxygenation in Nonintubated Patients as Bridge to Lung Transplantation. Am J Transplant. 2010;10(9):2173-8. Epub 2010/07/20.

2008

Meyer A, Struber M, Fischer S. Advances in Extracorporeal Ventilation. Anesthesiol Clin. 2008;26(2):381-91, viii.

Fischer S, Hoeper MM, Bein T, Simon AR, Gottlieb J, Wisser W, Frey L, Van Raemdonck D, Welte T, Haverich A, Strueber M. Interventional Lung Assist: A New Concept of Protective Ventilation in Bridge to Lung Transplantation. ASAIO J. 2008;54(1):3-10. Epub 2008/01/22.

2007

Fischer S, Bohn D, Rycus P, Pierre AF, de Perrot M, Waddell TK, Keshavjee S. Extracorporeal Membrane Oxygenation for Primary Graft Dysfunction after Lung Transplantation: Analysis of the Extracorporeal Life Support Organization (Elso) Registry. J Heart Lung Transplant. 2007;26(5):472-7.

Fischer S, Hoeper MM, Tomaszek S, Simon A, Gottlieb J, Welte T, Haverich A, Strueber M. Bridge to Lung Transplantation with the Extracorporeal Membrane Ventilator Novalung in the Veno-Venous Mode: The Initial Hannover Experience. ASAIO J. 2007;53(2):168-70.

2006

Fischer S, Simon AR, Welte T, Hoeper MM, Meyer A, Tessmann R, Gohrbandt B, Gottlieb J, Haverich A, Strueber M. Bridge to lung transplantation with the novel pumpless interventional lung assist device NovaLung. J Thorac Cardiovasc Surg. 2006;131(3):719-23. Epub 2006/03/07.

Unit 4.2 - Lung Regeneration and Repair

2017

Rojas SV, Meier M, Zweigerdt R, Eckardt D, Rathert C, Schecker N, Schmitto JD, Rojas-Hernandez S, Martin U, Kutschka I, Haverich A, Martens A. Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure. Artificial organs. 2017;41(2):192-9.

Jara-Avaca M, Kempf H, Ruckert M, Robles-Diaz D, Franke A, de la Roche J, Fischer M, Malan D, Sasse P, Solodenko W, Drager G, Kirschning A, Martin U, Zweigerdt R. EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival. Stem cell reports. 2017;8(2):305-17.

2016

Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knorr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T. Stiff matrix induces switch to pure beta-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes. Basic research in cardiology. 2016;111(6):68.

Warnecke G. Ex Vivo Treatment. Transplantation. 2016;100(7):1400-1.

Stanslowsky N, Jahn K, Venneri A, Naujock M, Haase A, Martin U, Frieling H, Wegner F. Functional effects of cannabinoids during dopaminergic specification of human neural precursors derived from induced pluripotent stem cells. Addiction biology. 2016.

Merkert S, Martin U. Targeted genome engineering using designer nucleases: State of the art and practical guidance for application in human pluripotent stem cells. Stem cell research. 2016;16(2):377-86.

Merkert S, Martin U. Site-Specific Genome Engineering in Human Pluripotent Stem Cells. International journal of molecular sciences. 2016;17(7).

Kropp C, Kempf H, Halloin C, Robles-Diaz D, Franke A, Scheper T, Kinast K, Knorpp T, Joos TO, Haverich A, Martin U, Zweigerdt R, Olmer R. Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors. Stem cells translational medicine. 2016;5(10):1289-301.

Klawitter S, Fuchs NV, Upton KR, Munoz-Lopez M, Shukla R, Wang J, Garcia-Canadas M, Lopez-Ruiz C, Gerhardt DJ, Sebe A, Grabundzija I, Merkert S, Gerdes P, Pulgarin JA, Bock A, Held U, Witthuhn A, Haase A, Sarkadi B, Lower J, Wolvetang EJ, Martin U, Ivics Z, Izsvak Z, Garcia-Perez JL, Faulkner GJ, Schumann GG. Reprogramming triggers endogenous L1 and Alu retrotransposition in human induced pluripotent stem cells. Nature communications. 2016;7:10286.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature communications. 2016;7:13602.

Borger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C. Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions. Molecular medicine. 2016;22.

Beckmann A, Schubert M, Hainz N, Haase A, Martin U, Tschernig T, Meier C. Ultrastructural demonstration of Cx43 gap junctions in induced pluripotent stem cells from human cord blood. Histochemistry and cell biology. 2016;146(5):529-37.

Becker S, Steinmeyer J, Avsar M, Hoffler K, Salman J, Haverich A, Warnecke G, Ochs M, Schnapper A. Evaluating acellular versus cellular perfusate composition during prolonged ex vivo lung perfusion after initial cold ischaemia for 24 hours. Transpl Int. 2016;29(1):88-97.

2015

Martin U. Pluripotent stem cells for disease modeling and drug screening: new perspectives for treatment of cystic fibrosis? Molecular and cellular pediatrics. 2015;2(1):15.

Effenberg A, Stanslowsky N, Klein A, Wesemann M, Haase A, Martin U, Dengler R, Grothe C, Ratzka A, Wegner F. Striatal Transplantation of Human Dopaminergic Neurons Differentiated From Induced Pluripotent Stem Cells Derived From Umbilical Cord Blood Using Lentiviral Reprogramming. Cell transplantation. 2015;24(10):2099-112.

Wiegmann B, Korossis S, Burgwitz K, Hurschler C, Fischer S, Haverich A, Kuehn C. In Vitro Comparison of Biological and Synthetic Materials for Skeletal Chest Wall Reconstruction. Ann Thorac Surg. 2015;99(3):991-8.

Verleden SE, Todd JL, Sato M, Palmer SM, Martinu T, Pavlisko EN, Vos R, Neyrinck A, Van Raemdonck D, Saito T, Oishi H, Keshavjee S, Greer M, Warnecke G, Gottlieb J, Haverich A. Impact of Clad Phenotype on Survival after Lung Retransplantation: A Multicenter Study. Am J Transplant. 2015;15(8):2223-30.

Tudorache I, Sommer W, Kuhn C, Wiesner O, Hadem J, Fuhner T, Ius F, Avsar M, Schwerk N, Bothig D, Gottlieb J, Welte T, Bara C, Haverich A, Hoeper MM, Warnecke G. Lung Transplantation for Severe Pulmonary Hypertension--Awake Extracorporeal Membrane Oxygenation for Postoperative Left Ventricular Remodelling. Transplantation. 2015;99(2):451-8. Epub 2014/08/15.

Sommer W, Marsch G, Kaufeld T, Rontgen P, Beutel G, Tongers J, Warnecke G, Tudorache I, Schieffer B, Haverich A, Kuhn C. Cardiac Awake Extracorporeal Life Support-Bridge to Decision? Artif Organs. 2015;39(5):400-8.

Sommer W, Knofel AK, Madrahimov N, Avsar M, Jonigk D, Salman J, Dreckmann K, Jansson K, Salguero G, Maus UA, Welte T, Haverich A, Warnecke G. Allogeneic Cd4+Cd25high T Cells Regulate Obliterative Bronchiolitis of Heterotopic Bronchus Allografts in Both Porcinized and Humanized Mouse Models. Transplantation. 2015;99(3):482-91. Epub 2015/02/20.

Sommer W, Knofel AK, Izykowski N, Oldhafer F, Avsar M, Jonigk D, Warnecke G, Haverich A. Physical Exercise Reduces Transplant Arteriosclerosis in a Mouse Aorta Transplantation Model. J Thorac Cardiovasc Surg. 2015;149(1):330-7.

Sommer W, Ius F, Salman J, Avsar M, Tudorache I, Kuhn C, Wiegmann B, Marsch G, Kaufeld T, Zinne N, Fuehner T, Greer M, Gottlieb J, Boethig D, Haverich A, Welte T, Warnecke G. Survival and Spirometry Outcomes after Lung Transplantation from Donors Aged 70 Years and Older. J Heart Lung Transplant. 2015;34(10):1325-33.

Rojas SV, Martens A, Zweigerdt R, Baraki H, Rathert C, Schecker N, Rojas-Hernandez S, Schwanke K, Martin U, Haverich A, Kutschka I. Transplantation Effectiveness of Induced Pluripotent Stem Cells Is Improved by a Fibrinogen Biomatrix in an Experimental Model of Ischemic Heart Failure. Tissue Eng Part A. 2015;21(13-14):1991-2000. Epub 2015/04/14.

Renne J, Lauermann P, Hinrichs JB, Schonfeld C, Sorrentino S, Gutberlet M, Jakob P, Haverich A, Warnecke G, Welte T, Wacker FK, Gottlieb J, Vogel-Claussen J. Chronic Lung Allograft Dysfunction: Oxygen-Enhanced T1-Mapping Mr Imaging of the Lung. Radiology. 2015;276(1):266-73.

Mashaqi B, Ismail I, Siemeni TT, Ruemke S, Fleissner F, Zhang R, Wiegmann B, Filitz J, Gottlieb J, Haverich A. Local Anesthetics Delivered through Pleural Drainages Improve Pain and Lung Function after Cardiac Surgery. Thorac Cardiovasc Surg. 2015. Epub 2015/09/04.

Martin U. New Muscle for Old Hearts: Engineering Tissue from Pluripotent Stem Cells. Hum Gene Ther. 2015;26(5):305-11.

Kugler C, Einhorn I, Gottlieb J, Warnecke G, Schwarz A, Barg-Hock H, Bara C, Haller H, Haverich A. Postoperative Weight Gain During the First Year after Kidney, Liver, Heart, and Lung Transplant: A Prospective Study. Prog Transplant. 2015;25(1):49-55. Epub 2015/03/12.

Kruger M, Zinne N, Shin H, Zhang R, Biancosino C, Kropivnitskaja I, Langer F, Haverich A, Dettmer S. [Minimally Invasive Chest Surgery : Is Palpation Control Still Necessary with Modern Computed Tomography?]. Chirurg. 2015. Epub 2015/05/29. Minimal-invasive Thoraxchirurgie : Macht die moderne Computertomographie die Palpationskontrolle verzichtbar?

Kempf H, Kropp C, Olmer R, Martin U, Zweigerdt R. Cardiac Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Nat Protoc. 2015;10(9):1345-61.

Katsirntaki K, Mauritz C, Olmer R, Schmeckebier S, Sgodda M, Puppe V, Eggenschwiler R, Duerr J, Schubert SC, Schmiedl A, Ochs M, Cantz T, Salwig I, Szibor M, Braun T, Rathert C, Martens A, Mall MA, Martin U. Bronchoalveolar Sublineage Specification of Pluripotent Stem Cells: Effect of Dexamethasone Plus Camp-Elevating Agents and Keratinocyte Growth Factor. Tissue Eng Part A. 2015;21(3-4):669-82.

Jonigk D, Izykowski N, Rische J, Braubach P, Kuhnel M, Warnecke G, Lippmann T, Kreipe H, Haverich A, Welte T, Gottlieb J, Laenger F. Molecular Profiling in Lung Biopsies of Human Pulmonary Allografts to Predict Chronic Lung Allograft Dysfunction. Am J Pathol. 2015;185(12):3178-88.

Ius F, Sommer W, Tudorache I, Kuhn C, Avsar M, Siemeni T, Salman J, Hallensleben M, Kieneke D, Greer M, Gottlieb J, Kielstein JT, Boethig D, Welte T, Haverich A, Warnecke G. Preemptive Treatment with Therapeutic Plasma Exchange and Rituximab for Early Donor-Specific Antibodies after Lung Transplantation. J Heart Lung Transplant. 2015;34(1):50-8.

Ius F, Sommer W, Tudorache I, Avsar M, Siemeni T, Salman J, Puntigam J, Optenhoefel J, Greer M, Welte T, Wiesner O, Haverich A, Hoeper M, Kuehn C, Warnecke G. Veno-Veno-Arterial Extracorporeal Membrane Oxygenation for Respiratory Failure with Severe Haemodynamic Impairment: Technique and Early Outcomes. Interact Cardiovasc Thorac Surg. 2015;20(6):761-7.

Ius F, Sommer W, Tudorache I, Avsar M, Siemeni T, Salman J, Molitoris U, Gras C, Juettner B, Puntigam J, Optenhoefel J, Greer M, Schwerk N, Gottlieb J, Welte T, Hoeper MM, Haverich A, Kuehn C, Warnecke G. Five-Year Experience with Intraoperative Extracorporeal Membrane Oxygenation in Lung Transplantation: Indications and Midterm Results. J Heart Lung Transplant. 2015.

Harms A, Fuehner T, Warnecke G, Haverich A, Gottlieb J, Trummer A. Epithelial and Erythrocyte Microvesicles from Bronchoalveolar Lavage Fluid Are Elevated and Associated with Outcome in Chronic Lung Allograft Dysfunction. Transplantation. 2015;99(11):2394-400.

Gohrbandt B, Warnecke G, Fischer S, Simon AR, Gottlieb J, Niehaus A, Bothig D, Haverich A, Strueber M. Retrograde in Situ Versus Antegrade Pulmonary Preservation in Clinical Lung Transplantation: A Single-Centre Experience. Eur J Cardiothorac Surg. 2015.

Gohrbandt B, Simon AR, Warnecke G, Fischer S, Hagl C, Niehaus A, Gottlieb J, Welte T, Haverich A, Strueber M. Lung Preservation with Perfadex or Celsior in Clinical Transplantation: A Retrospective Single-Center Analysis of Outcomes. Transplantation. 2015;99(9):1933-9.

Becker S, Steinmeyer J, Avsar M, Hoffler K, Salman J, Haverich A, Warnecke G, Ochs M, Schnapper A. Evaluating Acellular Versus Cellular Perfusate Composition During Prolonged Ex Vivo Lung Perfusion after Initial Cold Ischaemia for 24 Hours. Transpl Int. 2015.

 

2014

Zweigerdt R, Gruh I, Martin U. Your Heart on a Chip: Ipsc-Based Modeling of Barth-Syndrome-Associated Cardiomyopathy. Cell Stem Cell. 2014;15(1):9-11.

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9.

Wiegmann B, Figueiredo C, Gras C, Pflaum M, Schmeckebier S, Korossis S, Haverich A, Blasczyk R. Prevention of Rejection of Allogeneic Endothelial Cells in a Biohybrid Lung by Silencing Hla-Class I Expression. Biomaterials. 2014;35(28):8123-33.

Stanslowsky N, Haase A, Martin U, Naujock M, Leffler A, Dengler R, Wegner F. Functional Differentiation of Midbrain Neurons from Human Cord Blood-Derived Induced Pluripotent Stem Cells. Stem Cell Res Ther. 2014;5(2):35.

Schwanke K, Merkert S, Kempf H, Hartung S, Jara-Avaca M, Templin C, Gohring G, Haverich A, Martin U, Zweigerdt R. Fast and Efficient Multitransgenic Modification of Human Pluripotent Stem Cells. Hum Gene Ther Methods. 2014;25(2):136-53.

Naujock M, Stanslowsky N, Reinhardt P, Sterneckert J, Haase A, Martin U, Kim KS, Dengler R, Wegner F, Petri S. Molecular and Functional Analyses of Motor Neurons Generated from Human Cord-Blood-Derived Induced Pluripotent Stem Cells. Stem Cells Dev. 2014;23(24):3011-20.

Merkert S, Wunderlich S, Bednarski C, Beier J, Haase A, Dreyer AK, Schwanke K, Meyer J, Gohring G, Cathomen T, Martin U. Efficient Designer Nuclease-Based Homologous Recombination Enables Direct Pcr Screening for Footprintless Targeted Human Pluripotent Stem Cells. Stem Cell Reports. 2014;2(1):107-18.

Martin U, Haverich A. Engineering Cardiac Muscle: New Ways to Refurbish Old Hearts? Eur J Cardiothorac Surg. 2014;45(2):216-9.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Zweigerdt R, Schwanke K, Rojas-Hernandez S, Martin U, Saito S, Schmitto JD, Haverich A, Kutschka I. Substantial Early Loss of Induced Pluripotent Stem Cells Following Transplantation in Myocardial Infarction. Artif Organs. 2014;38(11):978-84.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Hernandez SR, Schwanke K, Zweigerdt R, Martin U, Saito S, Haverich A, Kutschka I. Macroscopic Fluorescence Imaging: A Novel Technique to Monitor Retention and Distribution of Injected Microspheres in an Experimental Model of Ischemic Heart Failure. PLoS One. 2014;9(8):e101775.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Kempf H, Olmer R, Kropp C, Ruckert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Stem Cell Reports. 2014;3(6):1132-46.

Ius F, Sommer W, Tudorache I, Kuhn C, Avsar M, Siemeni T, Salman J, Hallensleben M, Kieneke D, Greer M, Gottlieb J, Haverich A, Warnecke G. Early Donor-Specific Antibodies in Lung Transplantation: Risk Factors and Impact on Survival. J Heart Lung Transplant. 2014;33(12):1255-63.

Hess C, Schwenke A, Wagener P, Franzka S, Laszlo Sajti C, Pflaum M, Wiegmann B, Haverich A, Barcikowski S. Dose-Dependent Surface Endothelialization and Biocompatibility of Polyurethane Noble Metal Nanocomposites. J Biomed Mater Res A. 2014;102(6):1909-20.

Effenberg A, Stanslowsky N, Klein A, Wesemann M, Haase A, Martin U, Dengler R, Grothe C, Ratzka A, Wegner F. Striatal Transplantation of Human Dopaminergic Neurons Differentiated from Induced Pluripotent Stem Cells Derived from Umbilical Cord Blood Using Lentiviral Reprogramming. Cell Transplant. 2014.

Bobylev D, Sommer W, Avsar M, Horke A, Haverich A, Warnecke G. Aortopulmonary Window: A Rare Untreated Adult Case. Heart Lung Circ. 2014;23(10):e235-6.

2013

Wiegmann B, Maurer A, Zhang R, Zardo P, Haverich A, Fischer S. Combined Pulmonary and Renal Support in a Single Extracorporeal Device. ASAIO J. 2013;59(4):433-8.

Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U. Keratinocyte Growth Factor and Dexamethasone Plus Elevated Camp Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type Ii Cells. Tissue Eng Part A. 2013;19(7-8):938-51.

Kues WA, Herrmann D, Barg-Kues B, Haridoss S, Nowak-Imialek M, Buchholz T, Streeck M, Grebe A, Grabundzija I, Merkert S, Martin U, Hall VJ, Rasmussen MA, Ivics Z, Hyttel P, Niemann H. Derivation and Characterization of Sleeping Beauty Transposon-Mediated Porcine Induced Pluripotent Stem Cells. Stem Cells Dev. 2013;22(1):124-35.

Kensah G, Roa Lara A, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Drager G, Ochs M, Haverich A, Gruh I, Martin U. Murine and Human Pluripotent Stem Cell-Derived Cardiac Bodies Form Contractile Myocardial Tissue in Vitro. Eur Heart J. 2013;34(15):1134-46.

Hartung S, Schwanke K, Haase A, David R, Franz WM, Martin U, Zweigerdt R. Directing Cardiomyogenic Differentiation of Human Pluripotent Stem Cells by Plasmid-Based Transient Overexpression of Cardiac Transcription Factors. Stem Cells Dev. 2013;22(7):1112-25.

Emmert MY, Emmert LS, Martens A, Ismail I, Schmidt-Richter I, Gawol A, Seifert B, Haverich A, Martin U, Gruh I. Higher Frequencies of Bcrp+ Cardiac Resident Cells in Ischaemic Human Myocardium. Eur Heart J. 2013;34(36):2830-8.

Dahlmann J, Krause A, Moller L, Kensah G, Mowes M, Diekmann A, Martin U, Kirschning A, Gruh I, Drager G. Fully Defined in Situ Cross-Linkable Alginate and Hyaluronic Acid Hydrogels for Myocardial Tissue Engineering. Biomaterials. 2013;34(4):940-51.

Dahlmann J, Kensah G, Kempf H, Skvorc D, Gawol A, Elliott DA, Drager G, Zweigerdt R, Martin U, Gruh I. The Use of Agarose Microwells for Scalable Embryoid Body Formation and Cardiac Differentiation of Human and Murine Pluripotent Stem Cells. Biomaterials. 2013;34(10):2463-71.

2013

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84.

Warnecke G, Moradiellos J, Tudorache I, Kuhn C, Avsar M, Wiegmann B, Sommer W, Ius F, Kunze C, Gottlieb J, Varela A, Haverich A. Normothermic Perfusion of Donor Lungs for Preservation and Assessment with the Organ Care System Lung before Bilateral Transplantation: A Pilot Study of 12 Patients. Lancet. 2012;380(9856):1851-8.

Templin C, Zweigerdt R, Schwanke K, Olmer R, Ghadri JR, Emmert MY, Muller E, Kuest SM, Cohrs S, Schibli R, Kronen P, Hilbe M, Reinisch A, Strunk D, Haverich A, Hoerstrup S, Luscher TF, Kaufmann PA, Landmesser U, Martin U. Transplantation and Tracking of Human-Induced Pluripotent Stem Cells in a Pig Model of Myocardial Infarction: Assessment of Cell Survival, Engraftment, and Distribution by Hybrid Single Photon Emission Computed Tomography/Computed Tomography of Sodium Iodide Symporter Transgene Expression. Circulation. 2012;126(4):430-9.

Olmer R, Lange A, Selzer S, Kasper C, Haverich A, Martin U, Zweigerdt R. Suspension Culture of Human Pluripotent Stem Cells in Controlled, Stirred Bioreactors. Tissue Eng Part C Methods. 2012;18(10):772-84.

Ius F, Kuehn C, Tudorache I, Sommer W, Avsar M, Boethig D, Fuehner T, Gottlieb J, Hoeper M, Haverich A, Warnecke G. Lung Transplantation on Cardiopulmonary Support: Venoarterial Extracorporeal Membrane Oxygenation Outperformed Cardiopulmonary Bypass. J Thorac Cardiovasc Surg. 2012;144(6):1510-6.

Mauritz C, Martin U. Embryonic Stem Cells: Differentiation into Respiratory Cell Derivatives. Research Signpost ed2012.

Unit 4.3 - Senescence in Vascular Regeneration

2016

Melk A, Baisantry A, Schmitt R. The yin and yang of autophagy in acute kidney injury. Autophagy. 2016;12(3):596-7.

Dong L, Nordlohne J, Ge S, Hertel B, Melk A, Rong S, Haller H, von Vietinghoff S. T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment. Journal of the American Society of Nephrology : JASN. 2016;27(6):1753-64.

Bhayadia R, Schmidt BM, Melk A, Homme M. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. J Gerontol A Biol Sci Med Sci. 2016;71(2):161-9.

Baisantry A, Bhayana S, Wrede C, Hegermann J, Haller H, Melk A, Schmitt R. The impact of autophagy on the development of senescence in primary tubular epithelial cells. Cell Cycle. 2016;15(21):2973-9.

Baisantry A, Bhayana S, Rong S, Ermeling E, Wrede C, Hegermann J, Pennekamp P, Sorensen-Zender I, Haller H, Melk A, Schmitt R. Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments. Journal of the American Society of Nephrology : JASN. 2016;27(6):1609-16.

2015

Wuttke M, Wong CS, Wuhl E, Epting D, Luo L, Hoppmann A, Doyon A, Li Y, Consortium CK, Sozeri B, Thurn D, Helmstadter M, Huber TB, Blydt-Hansen TD, Kramer-Zucker A, Mehls O, Melk A, Querfeld U, Furth SL, Warady BA, Schaefer F, Kottgen A. Genetic Loci Associated with Renal Function Measures and Chronic Kidney Disease in Children: The Pediatric Investigation for Genetic Factors Linked with Renal Progression Consortium. Nephrol Dial Transplant. 2015.

Trautmann A, Bodria M, Ozaltin F, Gheisari A, Melk A, Azocar M, Anarat A, Caliskan S, Emma F, Gellermann J, Oh J, Baskin E, Ksiazek J, Remuzzi G, Erdogan O, Akman S, Dusek J, Davitaia T, Ozkaya O, Papachristou F, Firszt-Adamczyk A, Urasinski T, Testa S, Krmar RT, Hyla-Klekot L, Pasini A, Ozcakar ZB, Sallay P, Cakar N, Galanti M, Terzic J, Aoun B, Caldas Afonso A, Szymanik-Grzelak H, Lipska BS, Schnaidt S, Schaefer F, PodoNet C. Spectrum of Steroid-Resistant and Congenital Nephrotic Syndrome in Children: The Podonet Registry Cohort. Clin J Am Soc Nephrol. 2015;10(4):592-600.

Thurn D, Doyon A, Sozeri B, Bayazit AK, Canpolat N, Duzova A, Querfeld U, Schmidt BM, Schaefer F, Wuhl E, Melk A, Consortium CS. Aortic Pulse Wave Velocity in Healthy Children and Adolescents: Reference Values for the Vicorder Device and Modifying Factors. Am J Hypertens. 2015;28(12):1480-8.

Stuart HM, Roberts NA, Hilton EN, McKenzie EA, Daly SB, Hadfield KD, Rahal JS, Gardiner NJ, Tanley SW, Lewis MA, Sites E, Angle B, Alves C, Lourenco T, Rodrigues M, Calado A, Amado M, Guerreiro N, Serras I, Beetz C, Varga RE, Silay MS, Darlow JM, Dobson MG, Barton DE, Hunziker M, Puri P, Feather SA, Goodship JA, Goodship TH, Lambert HJ, Cordell HJ, Group UVS, Saggar A, Kinali M, Group CS, Lorenz C, Moeller K, Schaefer F, Bayazit AK, Weber S, Newman WG, Woolf AS. Urinary Tract Effects of Hpse2 Mutations. J Am Soc Nephrol. 2015;26(4):797-804.

Sorensen-Zender I, Bhayana S, Susnik N, Rolli V, Batkai S, Baisantry A, Bahram S, Sen P, Teng B, Lindner R, Schiffer M, Thum T, Melk A, Haller H, Schmitt R. Zinc-Alpha2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart. J Am Soc Nephrol. 2015;26(11):2659-68.

Schmitt R, Susnik N, Melk A. Molecular Aspects of Renal Senescence. Curr Opin Organ Transplant. 2015;20(4):412-6.

Schmidt B, Thurn-Valsassina D, Duzowa A, Soezeri B, Bayazit A, Caliskan S, Querfeld U, Azukaitis K, Wuehl U, Schafer F, Melk A. 1d.06: Longitudinal Evaluation of Cardiovascular Risk after Pediatric Kidney Transplantation. J Hypertens. 2015;33 Suppl 1:e16.

Schmidt B, Thurn-Valsassina D, Beier R, Melk A. 3b.06: Cardiovascular Risk in Pediatric Recipients of Stem Cell Transplantation. J Hypertens. 2015;33 Suppl 1:e35.

Schildhorn C, Jacobi C, Weissbrodt A, Hermstedt C, Westhoff JH, Homme M, Bhayadia R, Gretz N, Falk CS, Schmitt R, Brocker V, Kranzlin B, Melk A. Renal Phenotype of Young and Old Telomerase-Deficient Mice. Mech Ageing Dev. 2015;150:65-73.

Hoenecke J, Hartmann H, Melk A. Arterial Hypertension in Children with Hemolytic Uremic Syndrome after Kidney Transplantation. Pediatr Transplant. 2015;19(5):504-9.

Doyon A, Fischer DC, Bayazit AK, Canpolat N, Duzova A, Sozeri B, Bacchetta J, Balat A, Buscher A, Candan C, Cakar N, Donmez O, Dusek J, Heckel M, Klaus G, Mir S, Ozcelik G, Sever L, Shroff R, Vidal E, Wuhl E, Gondan M, Melk A, Querfeld U, Haffner D, Schaefer F, Consortium CS. Markers of Bone Metabolism Are Affected by Renal Function and Growth Hormone Therapy in Children with Chronic Kidney Disease. PLoS One. 2015;10(2):e0113482.

Dong L, Nordlohne J, Ge S, Hertel B, Melk A, Rong S, Haller H, von Vietinghoff S. T Cell Cx3cr1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment. J Am Soc Nephrol. 2015.

Bhayadia R, Schmidt BM, Melk A, Homme M. Senescence-Induced Oxidative Stress Causes Endothelial Dysfunction. J Gerontol A Biol Sci Med Sci. 2015.

Baisantry A, Bhayana S, Rong S, Ermeling E, Wrede C, Hegermann J, Pennekamp P, Sorensen-Zender I, Haller H, Melk A, Schmitt R. Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments. J Am Soc Nephrol. 2015.

2014

Susnik N, Sorensen-Zender I, Rong S, von Vietinghoff S, Lu X, Rubera I, Tauc M, Falk CS, Alexander WS, Melk A, Haller H, Schmitt R. Ablation of Proximal Tubular Suppressor of Cytokine Signaling 3 Enhances Tubular Cell Cycling and Modifies Macrophage Phenotype During Acute Kidney Injury. Kidney Int. 2014;85(6):1357-68.

Sorensen-Zender I, Rong S, Susnik N, Zender S, Pennekamp P, Melk A, Haller H, Schmitt R. Renal Tubular Notch Signaling Triggers a Prosenescent State after Acute Kidney Injury. Am J Physiol Renal Physiol. 2014;306(8):F907-15.

Melk A, Tegtbur U, Hilfiker-Kleiner D, Eberhard J, Saretzki G, Eulert C, Kerling A, Nelius AK, Homme M, Strunk D, Berliner D, Rontgen P, Kuck M, Bauersachs J, Hilfiker A, Haverich A, Bara C, Stiesch M. Improvement of Biological Age by Physical Activity. Int J Cardiol. 2014;176(3):1187-9.

Lipska BS, Ranchin B, Iatropoulos P, Gellermann J, Melk A, Ozaltin F, Caridi G, Seeman T, Tory K, Jankauskiene A, Zurowska A, Szczepanska M, Wasilewska A, Harambat J, Trautmann A, Peco-Antic A, Borzecka H, Moczulska A, Saeed B, Bogdanovic R, Kalyoncu M, Simkova E, Erdogan O, Vrljicak K, Teixeira A, Azocar M, Schaefer F, PodoNet C. Genotype-Phenotype Associations in Wt1 Glomerulopathy. Kidney Int. 2014;85(5):1169-78.

Kumarswamy R, Volkmann I, Beermann J, Napp LC, Jabs O, Bhayadia R, Melk A, Ucar A, Chowdhury K, Lorenzen JM, Gupta SK, Batkai S, Thum T. Vascular Importance of the Mir-212/132 Cluster. Eur Heart J. 2014;35(45):3224-31.

Eberhard J, Stiesch M, Kerling A, Bara C, Eulert C, Hilfiker-Kleiner D, Hilfiker A, Budde E, Bauersachs J, Kuck M, Haverich A, Melk A, Tegtbur U. Moderate and Severe Periodontitis Are Independent Risk Factors Associated with Low Cardiorespiratory Fitness in Sedentary Non-Smoking Men Aged between 45 and 65 Years. J Clin Periodontol. 2014;41(1):31-7.

Doyon A, Kracht D, Bayazit AK, Deveci M, Duzova A, Krmar RT, Litwin M, Niemirska A, Oguz B, Schmidt BM, Sozeri B, Querfeld U, Melk A, Schaefer F, Wuhl E, Consortium CRS. Response to Intima-Media Thickness in Children--Need for More Parameters. Hypertension. 2014;63(5):e121-2.

Berkenkamp B, Susnik N, Baisantry A, Kuznetsova I, Jacobi C, Sorensen-Zender I, Broecker V, Haller H, Melk A, Schmitt R. In Vivo and in Vitro Analysis of Age-Associated Changes and Somatic Cellular Senescence in Renal Epithelial Cells. PLoS One. 2014;9(2):e88071.

Bauer A, Loos S, Wehrmann C, Horstmann D, Donnerstag F, Lemke J, Hillebrand G, Lobel U, Pape L, Haffner D, Bindt C, Ahlenstiel T, Melk A, Lehnhardt A, Kemper MJ, Oh J, Hartmann H. Neurological Involvement in Children with E. Coli O104:H4-Induced Hemolytic Uremic Syndrome. Pediatr Nephrol. 2014;29(9):1607-15.

2013

Sorensen-Zender I, Rong S, Susnik N, Lange J, Gueler F, Degen JL, Melk A, Haller H, Schmitt R. Role of Fibrinogen in Acute Ischemic Kidney Injury. Am J Physiol Renal Physiol. 2013;305(5):F777-85.

Schock-Kusch D, Geraci S, Ermeling E, Shulhevich Y, Sticht C, Hesser J, Stsepankou D, Neudecker S, Pill J, Schmitt R, Melk A. Reliability of Transcutaneous Measurement of Renal Function in Various Strains of Conscious Mice. PLoS One. 2013;8(8):e71519.

Melk A, Schildhorn C, Homme M, Knoch M, Schmidt BM, Serth J, Scherer S, Dohler B, Opelz G. Association of Single Nucleotide Polymorphisms on Chromosome 9p21.3 with Cardiovascular Death in Kidney Transplant Recipients. Transplantation. 2013;95(7):928-32.

Lipska BS, Iatropoulos P, Maranta R, Caridi G, Ozaltin F, Anarat A, Balat A, Gellermann J, Trautmann A, Erdogan O, Saeed B, Emre S, Bogdanovic R, Azocar M, Balasz-Chmielewska I, Benetti E, Caliskan S, Mir S, Melk A, Ertan P, Baskin E, Jardim H, Davitaia T, Wasilewska A, Drozdz D, Szczepanska M, Jankauskiene A, Higuita LM, Ardissino G, Ozkaya O, Kuzma-Mroczkowska E, Soylemezoglu O, Ranchin B, Medynska A, Tkaczyk M, Peco-Antic A, Akil I, Jarmolinski T, Firszt-Adamczyk A, Dusek J, Simonetti GD, Gok F, Gheissari A, Emma F, Krmar RT, Fischbach M, Printza N, Simkova E, Mele C, Ghiggeri GM, Schaefer F, PodoNet C. Genetic Screening in Adolescents with Steroid-Resistant Nephrotic Syndrome. Kidney Int. 2013;84(1):206-13.

Doyon A, Kracht D, Bayazit AK, Deveci M, Duzova A, Krmar RT, Litwin M, Niemirska A, Oguz B, Schmidt BM, Sozeri B, Querfeld U, Melk A, Schaefer F, Wuhl E, Consortium CS. Carotid Artery Intima-Media Thickness and Distensibility in Children and Adolescents: Reference Values and Role of Body Dimensions. Hypertension. 2013;62(3):550-6.

2012

Schmitt R, Melk A. New Insights on Molecular Mechanisms of Renal Aging. Am J Transplant. 2012;12(11):2892-900.

Braun H, Schmidt BM, Raiss M, Baisantry A, Mircea-Constantin D, Wang S, Gross ML, Serrano M, Schmitt R, Melk A. Cellular Senescence Limits Regenerative Capacity and Allograft Survival. J Am Soc Nephrol. 2012;23(9):1467-73.

2011

Sorensen I, Susnik N, Inhester T, Degen JL, Melk A, Haller H, Schmitt R. Fibrinogen, Acting as a Mitogen for Tubulointerstitial Fibroblasts, Promotes Renal Fibrosis. Kidney Int. 2011;80(10):1035-44.

Sorensen I, Rong S, Susnik N, Gueler F, Shushakova N, Albrecht M, Dittrich AM, von Vietinghoff S, Becker JU, Melk A, Bohlmann A, Reingruber S, Petzelbauer P, Haller H, Schmitt R. Bbeta(15-42) Attenuates the Effect of Ischemia-Reperfusion Injury in Renal Transplantation. J Am Soc Nephrol. 2011;22(10):1887-96.

Kracht D, Shroff R, Baig S, Doyon A, Jacobi C, Zeller R, Querfeld U, Schaefer F, Wuhl E, Schmidt BM, Melk A, Consortium CS. Validating a New Oscillometric Device for Aortic Pulse Wave Velocity Measurements in Children and Adolescents. Am J Hypertens. 2011;24(12):1294-9.

Jacobi C, Homme M, Melk A. Is Cellular Senescence Important in Pediatric Kidney Disease? Pediatr Nephrol. 2011;26(12):2121-31.

Unit 4.4 - Rational Cell Engineering

2017

Gaur P, Cebula M, Riehn M, Hillebrand U, Hauser H, Wirth D. Diet induced obesity has an influence on intrahepatic T cell responses. Metabolism. 2017;69:171-6.

2016

Tran DD, Koch A, Saran S, Armbrecht M, Ewald F, Koch M, Wahlicht T, Wirth D, Braun A, Nashan B, Gaestel M, Tamura T. Extracellular-signal regulated kinase (Erk1/2), mitogen-activated protein kinase-activated protein kinase 2 (MK2) and tristetraprolin (TTP) comprehensively regulate injury-induced immediate early gene (IEG) response in in vitro liver organ culture. Cellular signalling. 2016;28(5):438-47.

Spencer S, Gugliotta A, Godecke N, Hauser H, Wirth D. Epigenetic modulations rendering cell-to-cell variability and phenotypic metastability. Journal of genetics and genomics = Yi chuan xue bao. 2016;43(8):503-11.

Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Koster M, May T, Schulz TF, Hauser H, Wirth D. Proliferation status defines functional properties of endothelial cells. Cellular and molecular life sciences : CMLS. 2016.

Lempp FA, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S. Evidence that hepatitis B virus replication in mouse cells is limited by the lack of a host cell dependency factor. Journal of hepatology. 2016;64(3):556-64.

Kuehn A, Kletting S, de Souza Carvalho-Wodarz C, Repnik U, Griffiths G, Fischer U, Meese E, Huwer H, Wirth D, May T, Schneider-Daum N, Lehr CM. Human alveolar epithelial cells expressing tight junctions to model the air-blood barrier. Altex. 2016;33(3):251-60.

Bachmann M, Breitwieser T, Lipps C, Wirth D, Jordan I, Reichl U, Frensing T. Impaired antiviral response of adenovirus-transformed cell lines supports virus replication. The Journal of general virology. 2016;97(2):293-8.

2015

Lentiviral HNF4a-Vector (and others) used in a collaboration with Prof. Tosh, University of Bath, UK.

Lempp F, Mutz P, Lipps C, Wirth D, Bartenschlager R, Urban S. Hepatitis B Virus infection of heterokaryonic cells indicates the lack of dependency factor(s) in NTCP-expressing but HBV-restricted cell lines. J. Hepatology, accepted for publication.

Spencer S, Gugliotta A, Koenitzer J, Hauser H, Wirth D. Stability of Single Copy Transgene Expression in Chok1 Cells Is Affected by Histone Modifications but Not by DNA Methylation. J Biotechnol. 2015;195:15-29. Epub 2014/12/24.

Rand U, Riedel J, Hillebrand U, Shin D, Willenberg S, Behme S, Klawonn F, Koster M, Hauser H, Wirth D. Single-Cell Analysis Reveals Heterogeneity in Onset of Transgene Expression from Synthetic Tetracycline-Dependent Promoters. Biotechnol J. 2015;10(2):323-31. Epub 2015/01/15.

Ochel A, Cebula M, Riehn M, Hillebrand U, Lipps C, Schirmbeck R, Hauser H, Wirth D. Effective Intrahepatic Cd8+ T-Cell Immune Responses Are Induced by Low but Not High Numbers of Antigen-Expressing Hepatocytes. Cell Mol Immunol. 2015. Epub 2015/09/29.

2014

Rand U, Hillebrand U, Sievers S, Willenberg S, Koster M, Hauser H, Wirth D. Uncoupling of the Dynamics of Host-Pathogen Interaction Uncovers New Mechanisms of Viral Interferon Antagonism at the Single-Cell Level. Nucleic Acids Res. 2014;42(13):e109.

Lipps C, May T, Wirth D. 2.1 Generation of Cell Lines and Biotechnological Applications. Animal Cell Biotechnology In Biologics Production2014.

Lieber D, Hochdorfer D, Stoehr D, Schubert A, Lotfi R, May T, Wirth D, Sinzger C. A Permanently Growing Human Endothelial Cell Line Supports Productive Infection with Human Cytomegalovirus under Conditional Cell Growth Arrest. Biotechniques. 2014;59(3):127-36. Epub 2014/01/01.

Kruse N, Spencer S, Wirth D. 3.4 Rational Approaches for Transgene Expression: Targeted Integration and Episomal Maintenance. Animal Cell Biotechnology . In Biologics Production2014.

Dag F, Dolken L, Holzki J, Drabig A, Weingartner A, Schwerk J, Lienenklaus S, Conte I, Geffers R, Davenport C, Rand U, Koster M, Weiss S, Adler B, Wirth D, Messerle M, Hauser H, Cicin-Sain L. Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency. PLoS Pathog. 2014;10(2):e1003962.

2013

Lipps C, May T, Hauser H, Wirth D. Eternity and Functionality - Rational Access to Physiologically Relevant Cell Lines. Biol Chem. 2013;394(12):1637-48.

Haenebalcke L, Goossens S, Naessens M, Kruse N, Farhang Ghahremani M, Bartunkova S, Haigh K, Pieters T, Dierickx P, Drogat B, Nyabi O, Wirth D, Haigh JJ. Efficient Rosa26-Based Conditional and/or Inducible Transgenesis Using Rmce-Compatible F1 Hybrid Mouse Embryonic Stem Cells. Stem Cell Rev. 2013;9(6):774-85.

Haenebalcke L, Goossens S, Dierickx P, Bartunkova S, D'Hont J, Haigh K, Hochepied T, Wirth D, Nagy A, Haigh JJ. The Rosa26-Ipsc Mouse: A Conditional, Inducible, and Exchangeable Resource for Studying Cellular (De)Differentiation. Cell Rep. 2013;3(2):335-41.

Dag F, Weingartner A, Butueva M, Conte I, Holzki J, May T, Adler B, Wirth D, Cicin-Sain L. A New Reporter Mouse Cytomegalovirus Reveals Maintained Immediate-Early Gene Expression but Poor Virus Replication in Cycling Liver Sinusoidal Endothelial Cells. Virol J. 2013;10:197.

Cebula M, Ochel A, Hillebrand U, Pils MC, Schirmbeck R, Hauser H, Wirth D. An Inducible Transgenic Mouse Model for Immune Mediated Hepatitis Showing Clearance of Antigen Expressing Hepatocytes by Cd8+ T Cells. PLoS One. 2013;8(7):e68720.

2012

Botezatu L, Sievers S, Gama-Norton L, Schucht R, Hauser H, Wirth D. Genetic Aspects of Cell Line Development from a Synthetic Biology Perspective. Adv Biochem Eng Biotechnol. 2012;127:251-84.

Cruz PE., Cruz HJS, Barcia RN, Santos M, Pohl S, Gilljam M, Dittmar K, Lindenmaier W, Alici E. Ex-vivo expansion of human mesenchymal stem cells. In: The CliniBook: Clinical gene transfer, 2012, O.Cohen-Haguenauer, ed. (Paris) pp. 111-117, ISBN: 2842541715

Lindenmaier W, Macke L, Meyring W, Garritsen HSP, Dittmar KEJ, Lachmann K, Thomas M. Closed bag cultivation systems for the production of gene modified dendritic cells and MSC for clinical use. In: The CliniBook: Clinical gene transfer, 2012, O.Cohen-Haguenauer, ed. (Paris) pp. 121-127, ISBN: 2842541715.

2011

Wilke S, Groebe L, Maffenbeier V, Jager V, Gossen M, Josewski J, Duda A, Polle L, Owens RJ, Wirth D, Heinz DW, van den Heuvel J, Bussow K. Streamlining Homogeneous Glycoprotein Production for Biophysical and Structural Applications by Targeted Cell Line Development. PLoS One. 2011;6(12):e27829.

Schucht R, Lydford S, Andzinski L, Zauers J, Cooper J, Hauser H, Wirth D, May T. Rapid Establishment of G-Protein-Coupled Receptor-Expressing Cell Lines by Site-Specific Integration. J Biomol Screen. 2011;16(3):323-31.

Sandhu U, Cebula M, Behme S, Riemer P, Wodarczyk C, Metzger D, Reimann J, Schirmbeck R, Hauser H, Wirth D. Strict Control of Transgene Expression in a Mouse Model for Sensitive Biological Applications Based on Rmce Compatible Es Cells. Nucleic Acids Res. 2011;39(1):e1.

Lyszkiewicz M, Zietara N, Rohde M, Gekara NO, Jablonska J, Dittmar KE, Weiss S. Sign-R1+Mhc Ii+ Cells of the Splenic Marginal Zone--a Novel Type of Resident Dendritic Cells. J Leukoc Biol. 2011;89(4):607-15. Epub 2011/01/07.

Lohmeyer JA, Liu F, Kruger S, Lindenmaier W, Siemers F, Machens HG. Use of Gene-Modified Keratinocytes and Fibroblasts to Enhance Regeneration in a Full Skin Defect. Langenbecks Arch Surg. 2011;396(4):543-50. Epub 2011/03/04.

Lindenmaier W, Lachmann K, Meyring W, Garritsen H, Thomas M, Dittmar K. Innenbeschichtung Von Beuteln Für Die Kultur Adhärenter Humaner Zellen. BIOspektrum. 2011;17(1):32-4.

Lachmann K, Dohse A, Thomas M, Pohl S, Meyring W, Dittmar KEJ, Lindenmeier W, Klages CP. Surface Modification of Closed Plastic Bags for Adherent Cell Cultivation. European Physical Journal-Applied Physics. 2011;55(1).

Gama-Norton L, Botezatu L, Herrmann S, Schweizer M, Alves PM, Hauser H, Wirth D. Lentivirus Production Is Influenced by Sv40 Large T-Antigen and Chromosomal Integration of the Vector in Hek293 Cells. Hum Gene Ther. 2011;22(10):1269-79.

Carrondo M, Panet A, Wirth D, Coroadinha AS, Cruz P, Falk H, Schucht R, Dupont F, Geny-Fiamma C, Merten OW, Hauser H. Integrated Strategy for the Production of Therapeutic Retroviral Vectors. Hum Gene Ther. 2011;22(3):370-9.

Alkharsah KR, Singh VV, Bosco R, Santag S, Grundhoff A, Konrad A, Sturzl M, Wirth D, Dittrich-Breiholz O, Kracht M, Schulz TF. Deletion of Kaposi's Sarcoma-Associated Herpesvirus Flice Inhibitory Protein, Vflip, from the Viral Genome Compromises the Activation of Stat1-Responsive Cellular Genes and Spindle Cell Formation in Endothelial Cells. J Virol. 2011;85(19):10375-88.

2010

Surdziel E, Eder M, Scherr M. Lentivirus-Mediated Antagomir Expression. Immunotherapy of Cancer: Methods and Protocols. 2010;667:237-48. Epub 2010/09/10.

Shahab-Osterloh S, Witte F, Hoffmann A, Winkel A, Laggies S, Neumann B, Seiffart V, Lindenmaier W, Gruber AD, Ringe J, Haupl T, Thorey F, Willbold E, Corbeau P, Gross G. Mesenchymal Stem Cell-Dependent Formation of Heterotopic Tendon-Bone Insertions (Osteotendinous Junctions). Stem Cells. 2010;28(9):1590-601.

Nehlsen K, Herrmann S, Zauers J, Hauser H, Wirth D. Toxin-Antitoxin Based Transgene Expression in Mammalian Cells. Nucleic Acids Res. 2010;38(5):e32.

May T, Butueva M, Bantner S, Markusic D, Seppen J, MacLeod RA, Weich H, Hauser H, Wirth D. Synthetic Gene Regulation Circuits for Control of Cell Expansion. Tissue Eng Part A. 2010;16(2):441-52.

Macke L, Garritsen HS, Meyring W, Hannig H, Pagelow U, Wormann B, Piechaczek C, Geffers R, Rohde M, Lindenmaier W, Dittmar KE. Evaluating Maturation and Genetic Modification of Human Dendritic Cells in a New Polyolefin Cell Culture Bag System. Transfusion. 2010;50(4):843-55.

Loew R, Meyer Y, Kuehlcke K, Gama-Norton L, Wirth D, Hauser H, Stein S, Grez M, Thornhill S, Thrasher A, Baum C, Schambach A. A New Pg13-Based Packaging Cell Line for Stable Production of Clinical-Grade Self-Inactivating Gamma-Retroviral Vectors Using Targeted Integration. Gene Ther. 2010;17(2):272-80.

Garritsen HS, Macke L, Meyring W, Hannig H, Pagelow U, Wormann B, Geffers R, Dittmar KE, Lindenmaier W. Efficient Generation of Clinical-Grade Genetically Modified Dendritic Cells for Presentation of Multiple Tumor-Associated Proteins. Transfusion. 2010;50(4):831-42.

Gama-Norton L, Herrmann S, Schucht R, Coroadinha AS, Low R, Alves PM, Bartholomae CC, Schmidt M, Baum C, Schambach A, Hauser H, Wirth D. Retroviral Vector Performance in Defined Chromosomal Loci of Modular Packaging Cell Lines. Hum Gene Ther. 2010;21(8):979-91.

2009

Dogan Y, Ganser A, Scherr M, Eder M. Quantification of Transforming Capacity and Cooperation of Defined Genetic Alterations in Myeloid Malignancies. Exp Hematol. 2010;38(1):11-9. Epub 2009/10/20.

Dittmar KE, Simann M, Zghoul N, Schon O, Meyring W, Hannig H, Macke L, Dirks WG, Miller K, Garritsen HS, Lindenmaier W. Quality of Cell Products: Authenticity, Identity, Genomic Stability and Status of Differentiation. Transfus Med Hemother. 2010;37(2):57-64. Epub 2010/08/26.

Spanholtz T, Maichle A, Niedworok C, Stoeckelhuber BM, Kruger S, Wedel T, Aach T, Middeler G, Hellwig-Burgel T, Bader A, Krengel S, Muller OJ, Franz WM, Lindenmaier W, Machens HG. Timing and Targeting of Cell-Based Vegf165 Gene Expression in Ischemic Tissue. J Surg Res. 2009;151(1):153-62.

Scherr M, Venturini L, Eder M. Knock-Down of Gene Expression in Hematopoietic Cells. Methods Mol Biol. 2009;506:207-19.

Nehlsen K, Schucht R, da Gama-Norton L, Kromer W, Baer A, Cayli A, Hauser H, Wirth D. Recombinant Protein Expression by Targeting Pre-Selected Chromosomal Loci. BMC Biotechnol. 2009;9:100.

2008

May T, Eccleston L, Herrmann S, Hauser H, Goncalves J, Wirth D. Bimodal and Hysteretic Expression in Mammalian Cells from a Synthetic Gene Circuit. PLoS One. 2008;3(6):e2372.

Ma B, Wang L, von Wasielewski R, Lindenmaier W, Dittmar KE. Serial Sectioning and Three-Dimensional Reconstruction of Mouse Peyer's Patch. Micron. 2008;39(7):967-75.

Ma B, Lin Z, Winkelbach S, Lindenmaier W, Dittmar KE. Automatic Registration of Serial Sections of Mouse Lymph Node by Using Image-Reg. Micron. 2008;39(4):387-96.

Klopper J, Lindenmaier W, Fiedler U, Mehlhorn A, Stark GB, Finkenzeller G. High Efficient Adenoviral-Mediated Vegf and Ang-1 Gene Delivery into Osteogenically Differentiated Human Mesenchymal Stem Cells. Microvasc Res. 2008;75(1):83-90.

2007

Wirth D, Gama-Norton L, Riemer P, Sandhu U, Schucht R, Hauser H. Road to Precision: Recombinase-Based Targeting Technologies for Genome Engineering. Curr Opin Biotechnol. 2007;18(5):411-9.

Scherr M, Venturini L, Battmer K, Schaller-Schoenitz M, Schaefer D, Dallmann I, Ganser A, Eder M. Lentivirus-Mediated Antagomir Expression for Specific Inhibition of Mirna Function. Nucleic Acids Res. 2007;35(22):e149.

May T, Hauser H, Wirth D. In Vitro Expansion of Tissue Cells by Conditional Proliferation. Methods Mol Med. 2007;140:1-15.

Ma B, Zimmermann T, Rohde M, Winkelbach S, He F, Lindenmaier W, Dittmar KE. Use of Autostitch for Automatic Stitching of Microscope Images. Micron. 2007;38(5):492-9.

Ma B, von Wasielewski R, Lindenmaier W, Dittmar KE. Immmunohistochemical Study of the Blood and Lymphatic Vasculature and the Innervation of Mouse Gut and Gut-Associated Lymphoid Tissue. Anat Histol Embryol. 2007;36(1):62-74.

Ma B, Jablonska J, Lindenmaier W, Dittmar KE. Immunohistochemical Study of the Reticular and Vascular Network of Mouse Lymph Node Using Vibratome Sections. Acta Histochem. 2007;109(1):15-28.

Ma B, He F, Jablonska J, Winkelbach S, Lindenmaier W, Zeng AP, Dittmar KE. Six-Color Segmentation of Multicolor Images in the Infection Studies of Listeria Monocytogenes. Microsc Res Tech. 2007;70(2):171-8.

Unit 5.1 - Secreted Factors and non-cell-based Strategies for Cardiac Regeneration

2017

Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO molecular medicine. 2017;9(2):265-79.

Appari M, Breitbart A, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Muller OJ, Bauersachs J, Heineke J. C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circulation research. 2017;120(1):66-77.

2016

Thackeray JT, Bankstahl JP, Wang Y, Wollert KC, Bengel FM. Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction. Theranostics. 2016;6(11):1768-79.

Haddad S, Wang Y, Galy B, Korf-Klingebiel M, Hirsch V, Baru AM, Rostami F, Reboll MR, Heineke J, Flogel U, Groos S, Renner A, Toischer K, Zimmermann F, Engeli S, Jordan J, Bauersachs J, Hentze MW, Wollert KC, Kempf T. Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure. European heart journal. 2016.

2015

Wollert KC. Ischaemic risk and bleeding risk in acute coronary syndrome: still inseparable. Eur Heart J. 2015; in press (Editorial).

Wollert KC. Bone Marrow Mononuclear Cell Therapy for Acute Myocardial Infarction: We Know What We Want, but We Just Don't Know How Yet. Heart. 2015;101(5):337-8. Epub 2015/01/21.

Thackeray JT, Derlin T, Haghikia A, Napp LC, Wang Y, Ross TL, Schafer A, Tillmanns J, Wester HJ, Wollert KC, Bauersachs J, Bengel FM. Molecular Imaging of the Chemokine Receptor Cxcr4 after Acute Myocardial Infarction. JACC Cardiovasc Imaging. 2015.

Thackeray JT, Bankstahl JP, Wang Y, Wollert KC, Bengel FM. Clinically Relevant Strategies for Lowering Cardiomyocyte Glucose Uptake for F-18-Fdg Imaging of Myocardial Inflammation in Mice. European Journal of Nuclear Medicine and Molecular Imaging. 2015;42(5):771-80.

Thackeray JT, Bankstahl JP, Wang Y, Korf-Klingebiel M, Walte A, Wittneben A, Wollert KC, Bengel FM. Targeting Post-Infarct Inflammation by Pet Imaging: Comparison of Ga-68-Citrate and Ga-68-Dotatate with F-18-Fdg in a Mouse Model. European Journal of Nuclear Medicine and Molecular Imaging. 2015;42(2):317-27.

Sinning JM, Wollert KC, Sedaghat A, Widera C, Radermacher MC, Descoups C, Hammerstingl C, Weber M, Stundl A, Ghanem A, Widder J, Vasa-Nicotera M, Mellert F, Schiller W, Bauersachs J, Zur B, Holdenrieder S, Welz A, Grube E, Pencina MJ, Nickenig G, Werner N, Kempf T. Risk Scores and Biomarkers for the Prediction of 1-Year Outcome after Transcatheter Aortic Valve Replacement. Am Heart J. 2015;170(4):821-9.

Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schonfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC. Myeloid-Derived Growth Factor (C19orf10) Mediates Cardiac Repair Following Myocardial Infarction. Nature Medicine. 2015;21(2):52-61.

Andersson C, Preis SR, Beiser A, DeCarli C, Wollert KC, Wang TJ, Januzzi JL, Jr., Vasan RS, Seshadri S. Associations of Circulating Growth Differentiation Factor-15 and St2 Concentrations with Subclinical Vascular Brain Injury and Incident Stroke. Stroke. 2015;46(9):2568-75.

2014

Xanthakis V, Enserro DM, Murabito JM, Polak JF, Wollert KC, Januzzi JL, Wang TJ, Tofler G, Vasan RS. Ideal Cardiovascular Health: Associations with Biomarkers and Subclinical Disease and Impact on Incidence of Cardiovascular Disease in the Framingham Offspring Study. Circulation. 2014;130(19):1676-83.

Gopal DM, Larson MG, Januzzi JL, Cheng S, Ghorbani A, Wollert KC, Kempf T, D'Agostino RB, Polak JF, Ramachandran VS, Wang TJ, Ho JE. Biomarkers of Cardiovascular Stress and Subclinical Atherosclerosis in the Community. Clin Chem. 2014;60(11):1402-8.

Delewi R, Hirsch A, Tijssen JG, Schachinger V, Wojakowski W, Roncalli J, Aakhus S, Erbs S, Assmus B, Tendera M, Turan RG, Corti R, Henry T, Lemarchand P, Lunde K, Cao F, Huikuri HV, Surder D, Simari RD, Janssens S, Wollert KC, Plewka M, Grajek S, Traverse JH, Zijlstra F, Piek JJ. Impact of Intracoronary Bone Marrow Cell Therapy on Left Ventricular Function in the Setting of St-Segment Elevation Myocardial Infarction: A Collaborative Meta-Analysis. European Heart Journal. 2014;35(15):989-98.

Bar C, Bernardes de Jesus B, Serrano R, Tejera A, Ayuso E, Jimenez V, Formentini I, Bobadilla M, Mizrahi J, de Martino A, Gomez G, Pisano D, Mulero F, Wollert KC, Bosch F, Blasco MA. Telomerase Expression Confers Cardioprotection in the Adult Mouse Heart after Acute Myocardial Infarction. Nat Commun. 2014;5:5863.

Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, Wollert KC, Schieffer B, Gaestel M, Bauersachs J, Bavendiek U. Deficiency of Mapk-Activated Protein Kinase 2 (Mk2) Prevents Adverse Remodelling and Promotes Endothelial Healing after Arterial Injury. Thromb Haemost. 2014;112(6):1264-76.

2013

Widera C, Pencina MJ, Bobadilla M, Reimann I, Guba-Quint A, Marquardt I, Bethmann K, Korf-Klingebiel M, Kempf T, Lichtinghagen R, Katus HA, Giannitsis E, Wollert KC. Incremental Prognostic Value of Biomarkers Beyond the Grace (Global Registry of Acute Coronary Events) Score and High-Sensitivity Cardiac Troponin T in Non-St-Elevation Acute Coronary Syndrome. Clinical Chemistry. 2013;59(10):1497-505.

Breitbart A, Scharf GM, Duncker D, Widera C, Gottlieb J, Vogel A, Schmidt S, Brandes G, Heuft HG, Lichtinghagen R, Kempf T, Wollert KC, Bauersachs J, Heineke J. Highly Specific Detection of Myostatin Prodomain by an Immunoradiometric Sandwich Assay in Serum of Healthy Individuals and Patients. Plos One. 2013;8(11).

Bengel FM, George RT, Schuleri KH, Lardo AC, Wollert KC. Image-Guided Therapies for Myocardial Repair: Concepts and Practical Implementation. European Heart Journal-Cardiovascular Imaging. 2013;14(8):741-51.

2012

Widera C, Pencina MJ, Meisner A, Kempf T, Bethmann K, Marquardt I, Katus HA, Giannitsis E, Wollert KC. Adjustment of the Grace Score by Growth Differentiation Factor 15 Enables a More Accurate Appreciation of Risk in Non-St-Elevation Acute Coronary Syndrome. European Heart Journal. 2012;33(9):1095-104.

Widera C, Giannitsis E, Kempf T, Korf-Klingebiel M, Fiedler B, Sharma S, Katus HA, Asaumi Y, Shimano M, Walsh K, Wollert KC. Identification of Follistatin-Like 1 by Expression Cloning as an Activator of the Growth Differentiation Factor 15 Gene and a Prognostic Biomarker in Acute Coronary Syndrome. Clinical Chemistry. 2012;58(8):1233-41.

Wang TJ, Wollert KC, Larson MG, Coglianese E, McCabe EL, Cheng SS, Ho JE, Fradley MG, Ghorbani A, Xanthakis V, Kempf T, Benjamin EJ, Levy D, Vasan RS, Januzzi JL. Prognostic Utility of Novel Biomarkers of Cardiovascular Stress the Framingham Heart Study. Circulation. 2012;126(13):1596-+.

2011

Korf-Klingebiel M, Kempf T, Schluter KD, Willenbockel C, Brod T, Heineke J, Schmidt VJ, Jantzen F, Brandes RP, Sugden PH, Drexler H, Molkentin JD, Wollert KC. Conditional Transgenic Expression of Fibroblast Growth Factor 9 in the Adult Mouse Heart Reduces Heart Failure Mortality after Myocardial Infarction. Circulation. 2011;123(5):504-U109.

Kempf T, Zarbock A, Widera C, Butz S, Stadtmann A, Rossaint J, Bolomini-Vittori M, Korf-Klingebiel M, Napp LC, Hansen B, Kanwischer A, Bavendiek U, Beutel G, Hapke M, Sauer MG, Laudanna C, Hogg N, Vestweber D, Wollert KC. Gdf-15 Is an Inhibitor of Leukocyte Integrin Activation Required for Survival after Myocardial Infarction in Mice. Nature Medicine. 2011;17(5):581-U101.

Bonaca MP, Morrow DA, Braunwald E, Cannon CP, Jiang ST, Breher S, Sabatine MS, Kempf T, Wallentin L, Wollert KC. Growth Differentiation Factor-15 and Risk of Recurrent Events in Patients Stabilized after Acute Coronary Syndrome Observations from Prove It-Timi 22. Arteriosclerosis Thrombosis and Vascular Biology. 2011;31(1):203-10.

2010

Wollert KC, Drexler H. Cell Therapy for the Treatment of Coronary Heart Disease: A Critical Appraisal. Nature Reviews Cardiology. 2010;7(4):204-15.

Anand IS, Kempf T, Rector TS, Tapken H, Allhoff T, Jantzen F, Kuskowski M, Cohn JN, Drexler H, Wollert KC. Serial Measurement of Growth-Differentiation Factor-15 in Heart Failure Relation to Disease Severity and Prognosis in the Valsartan Heart Failure Trial. Circulation. 2010;122(14):1387-+.

2009

Widera C, Horn-Wichmann R, Kempf T, Bethmann K, Fiedler B, Sharma S, Lichtinghagen R, Leitolf H, Ivandic B, Katus HA, Giannitsis E, Wollert KC. Circulating Concentrations of Follistatin-Like 1 in Healthy Individuals and Patients with Acute Coronary Syndrome as Assessed by an Immunoluminometric Sandwich Assay. Clinical Chemistry. 2009;55(10):1794-800.

Meyer GP, Wollert KC, Lotz J, Pirr J, Rager U, Lippolt P, Hahn A, Fichtner S, Schaefer A, Arseniev L, Ganser A, Drexler H. Intracoronary Bone Marrow Cell Transfer after Myocardial Infarction: 5-Year Follow-up from the Randomized-Controlled Boost Trial. European Heart Journal. 2009;30(24):2978-84.

2008

Korf-Klingebiel M, Kempf T, Sauer T, Brinkmann E, Fischer P, Meyer GP, Ganser A, Drexler H, Wollert KC. Bone Marrow Cells Are a Rich Source of Growth Factors and Cytokines: Implications for Cell Therapy Trials after Myocardial Infarction. European Heart Journal. 2008;29(23):2851-8.

2007

Wollert KC, Kempf T, Peter T, Olofsson S, James S, Johnston N, Lindahl B, Horn-Wichmann R, Brabant G, Simoons ML, Armstrong PW, Califf RM, Drexler H, Wallentin L. Prognostic Value of Growth-Differentiation Factor-15 in Patients with Non-St-Elevation Acute Coronary Syndrome. Circulation. 2007;115(8):962-71.

Wollert KC, Kempf T, Lagerqvist B, Lindahl B, Olofsson S, Allhoff T, Peter T, Siegbahn A, Venge P, Drexler H, Wallentin L. Growth Differentiation Factor 15 for Risk Stratification and Selection of an Invasive Treatment Strategy in Non-St-Elevation Acute Coronary Syndrome. Circulation. 2007;116(14):1540-8.

Kempf T, Von Haehling S, Cicoira M, Ponikowski P, Filippatos GS, Rozentryt P, Anker SD, Wollert KC. Prognostic Utility of Growth-Differentiation Factor-15 in Patients with Chronic Heart Failure. European Journal of Heart Failure. 2007;6:46-7.

Kempf T, Horn-Wichmann R, Brabant G, Peter T, Allhoff T, Klein G, Drexler H, Johnston N, Wallentin L, Wollert KC. Circulating Concentrations of Growth-Differentiation Factor 15 in Apparently Healthy Elderly Individuals and Patients with Chronic Heart Failure as Assessed by a New Immunoradiometric Sandwich Assay. Clinical Chemistry. 2007;53(2):284-91.

2006

Schaefer A, Meyer GP, Fuchs M, Klein G, Kaplan M, Wollert KC, Drexler H. Impact of Intracoronary Bone Marrow Cell Transfer on Diastolic Function in Patients after Acute Myocardial Infarction: Results from the Boost Trial. European Heart Journal. 2006;27(8):929-35.

Meyer GP, Wollert KC, Lotz J, Steffens J, Lippolt P, Fichtner S, Hecker H, Schaefer A, Arseniev L, Hertenstein B, Ganser A, Drexler H. Intracoronary Bone Marrow Cell Transfer after Myocardial Infarction - Eighteen Months' Follow-up Data from the Randomized, Controlled Boost (Bone Marrow Transfer to Enhance St-Elevation Infarct Regeneration) Trial. Circulation. 2006;113(10):1287-94.

Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H, Wollert KC. The Transforming Growth Factor-Beta Superfamily Member Growth-Differentiation Factor-15 Protects the Heart from Ischemia/Reperfusion Injury. Circulation Research. 2006;98(3):351-60.

Fiedler B, Feil R, Hofmann F, Willenbockel C, Drexler H, Smolenski A, Lohmann SM, Wollert KC. Cgmp-Dependent Protein Kinase Type I Inhibits Tab1-P38 Mitogen-Activated Protein Kinase Apoptosis Signaling in Cardiac Myocytes. Journal of Biological Chemistry. 2006;281(43):32831-40.

2005

Wollert KC, Drexler H. Clinical Applications of Stem Cells for the Heart. Circ Res. 2005;96(2):151-63.

Hofmann M, Wollert KC, Meyer GP, Menke A, Arseniev L, Hertenstein B, Ganser A, Knapp WH, Drexler H. Monitoring of Bone Marrow Cell Homing into the Infarcted Human Myocardium. Circulation. 2005;111(17):2198-202.

Heineke J, Ruetten H, Willenbockel C, Gross SC, Naguib M, Schaefer A, Kempf T, Hilfiker-Kleiner D, Caroni P, Kraft T, Kaiser RA, Molkentin JD, Drexler H, Wollert KC. Attenuation of Cardiac Remodeling after Myocardial Infarction by Muscle Lim Protein-Calcineurin Signaling at the Sarcomeric Z-Disc. Proceedings of the National Academy of Sciences of the United States of America. 2005;102(5):1655-60.

2004

Wollert KC, Meyer GP, Lotz J, Ringes-Lichtenberg S, Lippolt P, Breidenbach C, Fichtner S, Korte T, Hornig B, Messinger D, Arseniev L, Hertenstein B, Ganser A, Drexler H. Intracoronary Autologous Bone-Marrow Cell Transfer after Myocardial Infarction: The Boost Randomised Controlled Clinical Trial. Lancet. 2004;364(9429):141-8.

2002

Heineke J, Hilfiker A, Kempf T, Morawietz H, Lohmann SM, Drexler H, Wollert KC. Downregulation of Cytoskeletal Muscle Lim Protein by Nitric Oxide: Impact on Cardiac Myocyte Hypertrophy. Circulation. 2002;106(19):9-.

Unit 5.2 - Endogenous Regeneration Mechanisms of the Heart

2016

Ware JS, Li J, Mazaika E, Yasso CM, DeSouza T, Cappola TP, Tsai EJ, Hilfiker-Kleiner D, Kamiya CA, Mazzarotto F, Cook SA, Halder I, Prasad SK, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly DF, Wittstein IS, Thohan V, Zucker MJ, Liu P, Gorcsan J, 3rd, McNamara DM, Seidman CE, Seidman JG, Arany Z, Imac, Investigators I. Shared Genetic Predisposition in Peripartum and Dilated Cardiomyopathies. The New England journal of medicine. 2016;374(3):233-41.

Stapel B, Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JM, Roivainen A, Saraste A, Nickel AG, Saar JA, Sieve I, Pietzsch S, Muller M, Bogeski I, Kappl R, Jauhiainen M, Thackeray JT, Scherr M, Bengel FM, Hagl C, Tudorache I, Bauersachs J, Maack C, Hilfiker-Kleiner D. Low STAT3 expression sensitizes to toxic effects of beta-adrenergic receptor stimulation in peripartum cardiomyopathy. European heart journal. 2016.

Lux M, Andree B, Horvath T, Nosko A, Manikowski D, Hilfiker-Kleiner D, Haverich A, Hilfiker A. In vitro maturation of large-scale cardiac patches based on a perfusable starter matrix by cyclic mechanical stimulation. Acta biomaterialia. 2016;30:177-87.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease. Circulation. 2016;134(24):1973-90.

2015

Haghikia A, Rontgen P, Vogel-Claussen J, Schwab J, Westenfeld R, Ehlermann P, Berliner D, Podewski E, Hilfiker-Kleiner D, Bauersachs J. Prognostic implication of right ventricular involvement in peripartum cardiomyopathy: a cardiovascular magnetic resonance study. ESC heart failure. 2015;2(4):139-49.

Haghikia A, Kaya Z, Schwab J, Westenfeld R, Ehlermann P, Bachelier K, Oettl R, von Kaisenberg CS, Katus HA, Bauersachs J, Hilfiker-Kleiner D. Evidence of autoantibodies against cardiac troponin I and sarcomeric myosin in peripartum cardiomyopathy. Basic research in cardiology. 2015;110(6):60.

Hilfiker-Kleiner D. 'Social freezing' of women's eggs. Eur Heart J. 2015 Apr 1;36(13):773. (no REBIRTH-acknowledgement)

Ware J S, M R C P, Li J, Mazaika E, Yasso C M, DeSouza T, Cappola T, Tsai E J, Hilfiker-Kleiner D, Kamiya C A, Mazzarotto F, Cook S A, Halder I, Prasad S K, Pisarcik J, Hanley-Yanez K, Alharethi R, Damp J, Hsich E, Elkayam U, Sheppard R, Kealey A, Alexis J, Ramani G, Safirstein J, Boehmer J, Pauly D F, Wittstein I S, Thohan V, Zucker M J, Liu P, Gorcsan J, McNamara D M, Seidman C E, Seidman J G, Arany Z. Shared Genetic Etiology of Peripartum and Dilated Cardiomyopathies. N Engl J Med. 2015 Nov. Excepted for publication.

Westhoff-Bleck M, Hilfiker-Kleiner D. Marfan Syndrome and Pregnancy:Monitoring and Management. Eur Heart J. 2015;36(18):1066-7. Epub 2015/07/08.

Sliwa K, Hilfiker-Kleiner D. Cord Blood Samples: A Less Explored Tool in Early Diagnosis of Neonatal Cardiovascular Disease. J Am Coll Cardiol. 2015;66(8):940-2.

Schiffer M, Teng B, Gu C, Shchedrina VA, Kasaikina M, Pham VA, Hanke N, Rong S, Gueler F, Schroder P, Tossidou I, Park JK, Staggs L, Haller H, Erschow S, Hilfiker-Kleiner D, Wei C, Chen C, Tardi N, Hakroush S, Selig MK, Vasilyev A, Merscher S, Reiser J, Sever S. Pharmacological Targeting of Actin-Dependent Dynamin Oligomerization Ameliorates Chronic Kidney Disease in Diverse Animal Models. Nat Med. 2015;21(6):601-9.

Lux M, Andree B, Horvath T, Nosko A, Manikowski D, Hilfiker-Kleiner D, Haverich A, Hilfiker A. In Vitro Maturation of Large-Scale Cardiac Patches Based on a Perfusable Starter Matrix by Cyclic Mechanical Stimulation. Acta Biomater. 2015.

Hilfiker-Kleiner D, Westhoff-Bleck M, Gunter HH, von Kaisenberg CS, Bohnhorst B, Hoeltje M, Kuehn C. A Management Algorithm for Acute Heart Failure in Pregnancy. The Hannover Experience. Eur Heart J. 2015;36(13):769-70.

Hilfiker-Kleiner D, Haghikia A, Nonhoff J, Bauersachs J. Peripartum Cardiomyopathy: Current Management and Future Perspectives. Eur Heart J. 2015;36(18):1090-7.

Hilfiker-Kleiner D. Pregnancy Hormones in Cardiovascular Disease. Eur Heart J. 2015;36(18):1064-6.

Haghikia A, Podewski E, Berliner D, Sonnenschein K, Fischer D, Angermann CE, Bohm M, Rontgen P, Bauersachs J, Hilfiker-Kleiner D. Rationale and Design of a Randomized, Controlled Multicentre Clinical Trial to Evaluate the Effect of Bromocriptine on Left Ventricular Function in Women with Peripartum Cardiomyopathy. Clin Res Cardiol. 2015;104(11):911-7.

Haghikia A, Kaya Z, Schwab J, Westenfeld R, Ehlermann P, Bachelier K, Oettl R, von Kaisenberg CS, Katus HA, Bauersachs J, Hilfiker-Kleiner D. Evidence of Autoantibodies against Cardiac Troponin I and Sarcomeric Myosin in Peripartum Cardiomyopathy. Basic Res Cardiol. 2015;110(6):60.

Dutzmann J, Daniel JM, Bauersachs J, Hilfiker-Kleiner D, Sedding DG. Emerging Translational Approaches to Target Stat3 Signalling and Its Impact on Vascular Disease. Cardiovasc Res. 2015;106(3):365-74.

Duncker D, Bauersachs J, Hilfiker-Kleiner D, Veltmann C. Underestimated Risk for Life-Threatening Ventricular Arrhythmias in Newly Diagnosed Peripartum Cardiomyopathy? Eur Heart J. 2015;36(18):1067-8.

2014

Vukadinovic-Nikolic Z, Andree B, Dorfman SE, Pflaum M, Horvath T, Lux M, Venturini L, Bar A, Kensah G, Lara AR, Tudorache I, Cebotari S, Hilfiker-Kleiner D, Haverich A, Hilfiker A. Generation of Bioartificial Heart Tissue by Combining a Three-Dimensional Gel-Based Cardiac Construct with Decellularized Small Intestinal Submucosa. Tissue Engineering Part A. 2014;20(3-4):799-809.

van Spaendonck-Zwarts KY, Posafalvi A, van den Berg MP, Hilfiker-Kleiner D, Bollen IAE, Sliwa K, Alders M, Almomani R, van Langen IM, van der Meer P, Sinke RJ, van der Velden J, Van Veldhuisen DJ, van Tintelen JP, Jongbloed JDH. Titin Gene Mutations Are Common in Families with Both Peripartum Cardiomyopathy and Dilated Cardiomyopathy. European Heart Journal. 2014;35(32):2165-73.

Tarone G, Balligand JL, Bauersachs J, Clerk A, De Windt L, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Knoll R, Leite-Moreira AF, Lourenco AP, Mayr M, Thum T, Tocchetti CG. Targeting Myocardial Remodelling to Develop Novel Therapies for Heart Failure a Position Paper from the Working Group on Myocardial Function of the European Society of Cardiology. European Journal of Heart Failure. 2014;16(5):494-508.

Springer J, Tschirner A, Haghikia A, von Haehling S, Lal H, Grzesiak A, Kaschina E, Palus S, Ptsch M, von Websky K, Hocher B, Latouche C, Jaisser F, Morawietz L, Coats AJS, Beadle J, Argiles JM, Thum T, Flodes G, Doehner W, Hilfiker-Kleiner D, Force T, Anker SD. Prevention of Liver Cancer Cachexia-Induced Cardiac Wasting and Heart Failure. European Heart Journal. 2014;35(14):932-+.

Sliwa K, Hilfiker-Kleiner D, Mebazaa A, Petrie MC, Maggioni AP, Regitz-Zagrosek V, Schaufelberger M, Tavazzi L, van Veldhuisen DJ, Roos-Hesslink JW, Shah AJ, Seferovic PM, Elkayam U, van Spaendonck-Zwarts K, Bachelier-Walenta K, Mouquet F, Kraigher-Krainer E, Hall R, Ponikowski P, McMurray JJV, Pieske B. Eurobservational Research Programme: A Worldwide Registry on Peripartum Cardiomyopathy (Ppcm) in Conjunction with the Heart Failure Association of the European Society of Cardiology Working Group on Ppcm. European Journal of Heart Failure. 2014;16(5):583-91.

Scherr M, Elder A, Battmer K, Barzan D, Bomken S, Ricke-Hoch M, Schroder A, Venturini L, Blair HJ, Vormoor J, Ottmann O, Ganser A, Pich A, Hilfiker-Kleiner D, Heidenreich O, Eder M. Differential Expression of Mir-17 Similar to 92 Identifies Bcl2 as a Therapeutic Target in Bcr-Abl-Positive B-Lineage Acute Lymphoblastic Leukemia. Leukemia. 2014;28(3):554-65.

Ricke-Hoch M, Bultmann I, Stapel B, Condorelli G, Rinas U, Sliwa K, Scherr M, Hilfiker-Kleiner D. Opposing Roles of Akt and Stat3 in the Protection of the Maternal Heart from Peripartum Stress. Cardiovascular Research. 2014;101(4):587-96.

Radke MB, Taft MH, Stapel B, Hilfiker-Kleiner D, Preller M, Manstein DJ. Small Molecule-Mediated Refolding and Activation of Myosin Motor Function. Elife. 2014;3.

Melk A, Tegtbur U, Hilfiker-Kleiner D, Eberhard J, Saretzki G, Eulert C, Kerling A, Nelius AK, Homme M, Strunk D, Berliner D, Rontgen P, Kuck M, Bauersachs J, Hilfiker A, Haverich A, Bara C, Stiesch M. Improvement of Biological Age by Physical Activity. International Journal of Cardiology. 2014;176(3):1187-9.

Leite-Moreira AF, Lourenco AP, Balligand JL, Bauersachs J, Clerk A, De Windt LJ, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Kaminski KA, Knoll R, Mayr M, Tarone G, Thum T, Tocchetti CG. Esc Working Group on Myocardial Function Position Paper: How to Study the Right Ventricle in Experimental Models. European Journal of Heart Failure. 2014;16(5):509-18.

Kiyan Y, Tkachuk S, Hilfiker-Kleiner D, Haller H, Fuhrman B, Dumler I. Oxldl Induces Inflammatory Responses in Vascular Smooth Muscle Cells Via Urokinase Receptor Association with Cd36 and Tlr4. Journal of Molecular and Cellular Cardiology. 2014;66:72-82.

Hilfiker-Kleiner D, Sliwa K. Pathophysiology and Epidemiology of Peripartum Cardiomyopathy. Nature Reviews Cardiology. 2014;11(6):364-70.

Hilfiker-Kleiner D, Arany Z. Focus on Pregnancy-Mediated Heart and Vascular Disease. Cardiovascular Research. 2014;101(4):543-4.

Haghikia A, Ricke-Hoch M, Stapel B, Gorst I, Hilfiker-Kleiner D. Stat3, a Key Regulator of Cell-to-Cell Communication in the Heart. Cardiovascular Research. 2014;102(2):281-9.

Eberhard J, Stiesch M, Kerling A, Bara C, Eulert C, Hilfiker-Kleiner D, Hilfiker A, Budde E, Bauersachs J, Kuck M, Haverich A, Melk A, Tegtbur U. Moderate and Severe Periodontitis Are Independent Risk Factors Associated with Low Cardiorespiratory Fitness in Sedentary Non-Smoking Men Aged between 45 and 65 Years. Journal of Clinical Periodontology. 2014;41(1):31-7.

Duncker D, Haghikia A, Konig T, Hohmann S, Gutleben KJ, Westenfeld R, Oswald H, Klein H, Bauersachs J, Hilfiker-Kleiner D, Veltmann C. Risk for Ventricular Fibrillation in Peripartum Cardiomyopathy with Severely Reduced Left Ventricular Function-Value of the Wearable Cardioverter/Defibrillator. Eur J Heart Fail. 2014;16(12):1331-6.

Chowdhury A, Herzog C, Hasselbach L, Khouzani HL, Zhang J, Hammerschmidt M, Rudat C, Kispert A, Gaestel M, Menon MB, Tudorache I, Hilfiker-Kleiner D, Muhlfeld C, Schmitto JD, Muller M, Theilmeier G. Expression of Fibulin-6 in Failing Hearts and Its Role for Cardiac Fibroblast Migration. Cardiovasc Res. 2014;103(4):509-20.

Belge C, Hammond J, Dubois-Deruy E, Manoury B, Hamelet J, Beauloye C, Markl A, Pouleur AC, Bertrand L, Esfahani H, Jnaoui K, Gotz KR, Nikolaev VO, Vanderper A, Herijgers P, Lobysheva I, Iaccarino G, Hilfiker-Kleiner D, Tavernier G, Langin D, Dessy C, Balligand JL. Enhanced Expression of Beta 3-Adrenoceptors in Cardiac Myocytes Attenuates Neurohormone-Induced Hypertrophic Remodeling through Nitric Oxide Synthase. Circulation. 2014;129(4):451-62.

2013

Veldink H, Faulhaber-Walter R, Park JK, Martens-Lobenhoffer J, Bode-Boger S, Schuett H, Haghikia A, Hilfiker-Kleiner D, Kielstein JT. Effects of Chronic Sdma Infusion on Glomerular Filtration Rate, Blood Pressure, Myocardial Function and Renal Histology in C57bl6/J Mice. Nephrology Dialysis Transplantation. 2013;28(6):1434-9.

Mueller M, Herzog C, Larmann J, Schmitz M, Hilfiker-Kleiner D, Gessner JE, Theilmeier G. The Receptor for Activated Complement Factor 5 (C5ar) Conveys Myocardial Ischemic Damage by Mediating Neutrophil Transmigration. Immunobiology. 2013;218(9):1131-8.

Hermida N, Markl A, Hamelet J, Van Assche T, Vanderper A, Herijgers P, van Bilsen M, Hilfiker-Kleiner D, Noppe G, Beauloye C, Horman S, Balligand JL. Hmgcoa Reductase Inhibition Reverses Myocardial Fibrosis and Diastolic Dysfunction through Amp-Activated Protein Kinase Activation in a Mouse Model of Metabolic Syndrome. Cardiovascular Research. 2013;99(1):44-54.

Halkein J, Tabruyn SR, Ricke-Hoch M, Haghikia A, Nguyen NQN, Scherr M, Castermans K, Malvaux L, Lambert V, Thiry M, Sliwa K, Noel A, Martial JA, Hilfiker-Kleiner D, Struman I. Microrna-146a Is a Therapeutic Target and Biomarker for Peripartum Cardiomyopathy. Journal of Clinical Investigation. 2013;123(5):2143-54.

Haghikia A, Podewski E, Libhaber E, Labidi S, Fischer D, Roentgen P, Tsikas D, Jordan J, Lichtinghagen R, von Kaisenberg CS, Struman I, Bovy N, Sliwa K, Bauersachs J, Hilfiker-Kleiner D. Phenotyping and Outcome on Contemporary Management in a German Cohort of Patients with Peripartum Cardiomyopathy. Basic Research in Cardiology. 2013;108(4).

El Hasnaoui-Saadani R, Marchant D, Pichon A, Escoubet B, Pezet M, Hilfiker-Kleiner D, Hoch M, Pham I, Quidu P, Voituron N, Journe C, Richalet JP, Favret F. Epo Deficiency Alters Cardiac Adaptation to Chronic Hypoxia. Respiratory Physiology & Neurobiology. 2013;186(2):146-54.

2012

Yndestad A, Finsen AV, Ueland T, Husberg C, Dahl CP, Oie E, Vinge LE, Sjaastad I, Sandanger O, Ranheim T, Dickstein K, Kjekshus J, Damas JK, Fiane AE, Hilfiker-Kleiner D, Lipp M, Gullestad L, Christensen G, Aukrust P. The Homeostatic Chemokine Ccl21 Predicts Mortality and May Play a Pathogenic Role in Heart Failure. Plos One. 2012;7(3).

Walenta K, Schwarz V, Schirmer SH, Kindermann I, Friedrich EB, Solomayer EF, Sliwa K, Labidi S, Hilfiker-Kleiner D, Bohm M. Circulating Microparticles as Indicators of Peripartum Cardiomyopathy. European Heart Journal. 2012;33(12):1469-79.

Lindner D, Hilbrandt M, Marggraf K, Becher PM, Hilfiker-Kleiner D, Klingel K, Pauschinger M, Schultheiss H-P, Tschöpe C, Westermann D. Protective Function of Stat3 in Cvb3-Induced Myocarditis. Cardiology Research and Practice. 2012;2012:11.

Arany Z, Patten I, Rana S, Shahul S, Rowe G, Jang C, Liu L, Hacker M, Rhee J, Mitchell J, Mahmood F, Hess P, Farrell C, Koulisis N, Khankin E, Burke S, Tudorache I, Bauersachs J, del Monte F, Hilfiker-Kleiner D, Karumanchi A. Cardiac Angiogenic Imbalance Leads to Peripartum Cardiomyopathy. Circulation Research. 2012;111(4).

Unit 5.3 - Myocardial Cellular Crosstalk and Gene Therapy

2017

Malek Mohammadi M, Kattih B, Grund A, Froese N, Korf-Klingebiel M, Gigina A, Schrameck U, Rudat C, Liang Q, Kispert A, Wollert KC, Bauersachs J, Heineke J. The transcription factor GATA4 promotes myocardial regeneration in neonatal mice. EMBO molecular medicine. 2017;9(2):265-79.

Appari M, Breitbart A, Brandes F, Szaroszyk M, Froese N, Korf-Klingebiel M, Mohammadi MM, Grund A, Scharf GM, Wang H, Zwadlo C, Fraccarollo D, Schrameck U, Nemer M, Wong GW, Katus HA, Wollert KC, Muller OJ, Bauersachs J, Heineke J. C1q-TNF-Related Protein-9 Promotes Cardiac Hypertrophy and Failure. Circulation research. 2017;120(1):66-77.

2016

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease. Circulation. 2016;134(24):1973-90.

2015

Derda AA, Thum S, Lorenzen JM, Bavendiek U, Heineke J, Keyser B, Stuhrmann M, Givens RC, Kennel PJ, Schulze PC, Widder JD, Bauersachs J, Thum T. Blood-Based Microrna Signatures Differentiate Various Forms of Cardiac Hypertrophy. Int J Cardiol. 2015;196:115-22. Epub 2015/06/19.

Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J. Antiandrogenic Therapy with Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction. Circulation. 2015;131(12):1071-81.

Grund A, Heineke J. Exercise Makes the Difference: Deconstructing Physiological Hypertrophy in Swine. Journal of Molecular and Cellular Cardiology. 2015;79:89-91.

2014

Lorenzen JM, Kaucsar T, Schauerte C, Schmitt R, Rong S, Hubner A, Scherf K, Fiedler J, Martino F, Kumarswamy R, Kolling M, Sorensen I, Hinz H, Heineke J, van Rooij E, Haller H, Thum T. Microrna-24 Antagonism Prevents Renal Ischemia Reperfusion Injury. Journal of the American Society of Nephrology. 2014;25(12):2717-29.

2013

Breitbart A, Scharf GM, Duncker D, Widera C, Gottlieb J, Vogel A, Schmidt S, Brandes G, Heuft HG, Lichtinghagen R, Kempf T, Wollert KC, Bauersachs J, Heineke J. Highly Specific Detection of Myostatin Prodomain by an Immunoradiometric Sandwich Assay in Serum of Healthy Individuals and Patients. Plos One. 2013;8(11).

Heineke J. Screening for Novel Calcium-Binding Proteins That Regulate Cardiac Hypertrophy: Cib1 as an Example. Methods Mol Biol. 2013;963:279-301. Epub 2013/01/09.

2012

Heineke J, Ritter O. Cardiomyocyte Calcineurin Signaling in Subcellular Domains: From the Sarcolemma to the Nucleus and Beyond. Journal of Molecular and Cellular Cardiology. 2012;52(1):62-73.

Scharf G, Heineke J. Finding Good Biomarkers for Sarcopenia. Journal of Cachexia Sarcopenia and Muscle. 2012;3(3):145-8.

Heineke J. Wag the Dog How Endothelial Cells Regulate Cardiomyocyte Growth. Arteriosclerosis Thrombosis and Vascular Biology. 2012;32(3):545-7.

2011

Korf-Klingebiel M, Kempf T, Schluter KD, Willenbockel C, Brod T, Heineke J, Schmidt VJ, Jantzen F, Brandes RP, Sugden PH, Drexler H, Molkentin JD, Wollert KC. Conditional Transgenic Expression of Fibroblast Growth Factor 9 in the Adult Mouse Heart Reduces Heart Failure Mortality after Myocardial Infarction. Circulation. 2011;123(5):504-U109.

Froese N, Kattih B, Breitbart A, Grund A, Geffers R, Molkentin JD, Kispert A, Wollert KC, Drexler H, Heineke J. Gata6 Promotes Angiogenic Function and Survival in Endothelial Cells by Suppression of Autocrine Transforming Growth Factor Beta/Activin Receptor-Like Kinase 5 Signaling. Journal of Biological Chemistry. 2011;286(7):5680-90.

Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JTG, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T. Microrna-24 Regulates Vascularity after Myocardial Infarction. Circulation. 2011;124(6):720-U178.

Breitbart A, Auger-Messier M, Molkentin JD, Heineke J. Myostatin from the Heart: Local and Systemic Actions in Cardiac Failure and Muscle Wasting. American Journal of Physiology-Heart and Circulatory Physiology. 2011;300(6):H1973-H82.

Echtermeyer F, Harendza T, Hubrich S, Lorenz A, Herzog C, Mueller M, Schmitz M, Grund A, Larmann J, Stypmann J, Schieffer B, Lichtinghagen R, Hilfiker-Kleiner D, Wollert KC, Heineke J, Theilmeier G. Syndecan-4 Signalling Inhibits Apoptosis and Controls Nfat Activity During Myocardial Damage and Remodelling. Cardiovascular Research. 2011;92(1):123-31.

2010

Heineke J, Wollert KC, Osinska H, Sargent MA, York AJ, Robbins J, Molkentin JD. Calcineurin Protects the Heart in a Murine Model of Dilated Cardiomyopathy. Journal of Molecular and Cellular Cardiology. 2010;48(6):1080-7.

Heineke J, Auger-Messier M, Correll RN, Xu JA, Benard MJ, Yuan WP, Drexler H, Parise LV, Molkentin JD. Cib1 Is a Regulator of Pathological Cardiac Hypertrophy. Nature Medicine. 2010;16(8):872-U68.

Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, Molkentin JD. Genetic Deletion of Myostatin from the Heart Prevents Skeletal Muscle Atrophy in Heart Failure. Circulation. 2010;121(3):419-25.

2009

Gunkel S, Knoll R, Heineke J, Hilfiker-Kleiner D. Mlp: A Stress Sensor Goes Nuclear. Journal of Molecular and Cellular Cardiology. 2009;47(4):423-5.

2007

Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Cromblehol TM, Molkentin JD. Cardiomyocyte Gata4 Functions as a Stress-Responsive Regulator of Angiogenesis in the Murine Heart. Journal of Clinical Investigation. 2007;117(11):3198-210.

Gardiwal A, Klein G, Kraemer K, Durgac T, Koenig T, Niehaus M, Heineke J, Mohammadi B, Krampfl K, Schaefer A, Wollert KC, Korte T. Reduced Delayed Rectifier K+ Current, Altered Electrophysiology, and Increased Ventricular Vulnerability in Mlp-Deficient Mice. Journal of Cardiac Failure. 2007;13(8):687-93.

Unit 5.4 - Vascular Remodelling and Regeneration

2015

Daniel J. M., Prock A, Dutzmann J, Sonnenschein K MD, Thum T, Bauersachs J, Sedding DG. Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation. Arterioscler Thromb Vasc Biol. In Press.

Merseburger AS, Sedding D, Huter K. [Cardiovascular Risk Patients under Androgen Deprivation Therapy : Lower Risk with Gnrh Antagonists Compared to Lhrh Agonists?]. Urologe A. 2015. Kardiovaskulare Risikopatienten unter Androgenentzugstherapie : Geringeres Risiko mit GnRH-Antagonisten im Vergleich zu LHRH-Agonisten?

Gunduz D, Klewer M, Bauer P, Tanislav C, Sedding D, Rohrbach S, Schulz R, Aslam M. Compound C Inhibits in Vitro Angiogenesis and Ameliorates Thrombin-Induced Endothelial Barrier Failure. Eur J Pharmacol. 2015;768:165-72.

Medunjanin S, Daniel JM, Weinert S, Dutzmann J, Burgbacher F, Brecht S, Bruemmer D, Kahne T, Naumann M, Sedding DG, Zuschratter W, Braun-Dullaeus RC. DNA-Dependent Protein Kinase (DNA-Pk) Permits Vascular Smooth Muscle Cell Proliferation through Phosphorylation of the Orphan Nuclear Receptor Nor1. Cardiovasc Res. 2015;106(3):488-97. Epub 2015/04/09.

Daniel JM, Reich F, Dutzmann J, Weisheit S, Teske R, Gunduz D, Bauersachs J, Preissner KT, Sedding DG. Cleaved High-Molecular-Weight Kininogen Inhibits Neointima Formation Following Vascular Injury. Thromb Haemost. 2015;114(3):603-13.

Dutzmann J, Daniel JM, Bauersachs J, Hilfiker-Kleiner D, Sedding DG. Emerging Translational Approaches to Target Stat3 Signalling and Its Impact on Vascular Disease. Cardiovasc Res. 2015;106(3):365-74.

Tillmanns J, Hoffmann D, Habbaba Y, Schmitto JD, Sedding D, Fraccarollo D, Galuppo P, Bauersachs J. Fibroblast Activation Protein Alpha Expression Identifies Activated Fibroblasts after Myocardial Infarction. J Mol Cell Cardiol. 2015;87:194-203.

2014

Dutzmann J, Daniel JM, Bauersachs J, Sedding DG. MiR-92a – a key player in cardiovascular remodeling. RNA & Disease 2014; 1:e371.doi: 10.14800/rd.371

Assmus B, Leistner DM, Schachinger V, Erbs S, Elsasser A, Haberbosch W, Hambrecht R, Sedding D, Yu JT, Corti R, Mathey DG, Barth C, Mayer-Wehrstein C, Burck I, Sueselbeck T, Dill T, Hamm CW, Tonn T, Dimmeler S, Zeiher AM, Grp R-AS. Long-Term Clinical Outcome after Intracoronary Application of Bone Marrow-Derived Mononuclear Cells for Acute Myocardial Infarction: Migratory Capacity of Administered Cells Determines Event-Free Survival. European Heart Journal. 2014;35(19):1275-83.

Daniel JM, Penzkofer D, Teske R, Dutzmann J, Koch A, Bielenberg W, Bonauer A, Boon RA, Fischer A, Bauersachs J, van Rooij E, Dimmeler S, Sedding DG. Inhibition of Mir-92a Improves Re-Endothelialization and Prevents Neointima Formation Following Vascular Injury. Cardiovascular Research. 2014;103(4):564-72.

Kampschulte M, Gunkel I, Stieger P, Sedding DG, Brinkmann A, Ritman EL, Krombach GA, Langheinrich AC. Thalidomide Influences Atherogenesis in Aortas of Apoe(-/-)/Ldlr-/- Double Knockout Mice: A Nano-Ct Study. International Journal of Cardiovascular Imaging. 2014;30(4):795-802.

Savai R, Al-Tamari HM, Sedding D, Kojonazarov B, Muecke C, Teske R, Capecchi MR, Weissmann N, Grimminger F, Seeger W, Schermuly RT, Pullamsetti SS. Pro-Proliferative and Inflammatory Signaling Converge on Foxo1 Transcription Factor in Pulmonary Hypertension. Nature Medicine. 2014;20(11):1289-300.

2013

Babelova A, Sedding DG, Brandes RP. Anti-Atherosclerotic Mechanisms of Statin Therapy. Current Opinion in Pharmacology. 2013;13(2):260-4.

Dorr O, Liebetrau C, Mollmann H, Achenbach S, Sedding D, Szardien S, Willmer M, Rixe J, Troidl C, Elsasser A, Hamm C, Nef HM. Renal Sympathetic Denervation Does Not Aggravate Functional or Structural Renal Damage. Journal of the American College of Cardiology. 2013;61(4):479-80.

Sedding DG, Widmer-Teske R, Mueller A, Stieger P, Daniel JM, Gunduz D, Pullamsetti S, Nef H, Moellmann H, Troidl C, Hamm C, Braun-Dullaeus R. Role of the Phosphatase Pten in Early Vascular Remodeling. Plos One. 2013;8(3).

Aslam M, Sedding D, Koshty A, Santoso S, Schulz R, Hamm C, Gunduz D. Nucleoside Triphosphates Inhibit Adp, Collagen, and Epinephrine-Induced Platelet Aggregation: Role of P2y(1) and P2y(12) Receptors. Thrombosis Research. 2013;132(5):548-57.

2012

Dorr O, Mollmann H, Achenbach S, Sedding D, Basic D, Liebetrau C, Szardien S, Elsasser A, Roth P, Boning A, Hamm C, Nef HM. Transapical Coronary Artery Intervention "First-in-Man" Experience. Circulation-Cardiovascular Interventions. 2012;5(3):446-7.

Gunduz D, Aslam M, Krieger U, Becker L, Grebe M, Arshad M, Sedding DG, Hartel FV, Abdallah Y, Piper HM, Voss RK, Noll T. Opposing Effects of Atp and Adenosine on Barrier Function of Rat Coronary Microvasculature. Journal of Molecular and Cellular Cardiology. 2012;52(5):962-70.

Bloch M, Prock A, Paonessa F, Benz V, Bahr IN, Herbst L, Witt H, Kappert K, Spranger J, Stawowy P, Unger T, Fusco A, Sedding D, Brunetti A, Foryst-Ludwig A, Kintscher U. High-Mobility Group A1 Protein a New Coregulator of Peroxisome Proliferator-Activated Receptor-Gamma-Mediated Transrepression in the Vasculature. Circulation Research. 2012;110(3):394-U82.

Daniel JM, Dutzmann J, Bielenberg W, Widmer-Teske R, Gunduz D, Hamm CW, Sedding DG. Inhibition of Stat3 Signaling Prevents Vascular Smooth Muscle Cell Proliferation and Neointima Formation. Basic Research in Cardiology. 2012;107(3).

2011

Stolz E, Yeniguen M, Kreisel M, Kampschulte M, Doenges S, Sedding D, Ritman EL, Gerriets T, Langheinrich AC. Angioarchitectural Changes in Subacute Cerebral Venous Thrombosis. A Synchrotron-Based Micro- and Nano-Ct Study. Neuroimage. 2011;54(3):1881-6.

Sklepkiewicz P, Schermuly RT, Tian X, Ghofrani HA, Weissmann N, Sedding D, Kashour T, Seeger W, Grimminger F, Pullamsetti SS. Glycogen Synthase Kinase 3beta Contributes to Proliferation of Arterial Smooth Muscle Cells in Pulmonary Hypertension. Plos One. 2011;6(4).

Aslam M, Gunduz D, Schuler D, Li L, Sharifpanah F, Sedding D, Piper HM, Noll T. Intermedin Induces Loss of Coronary Microvascular Endothelial Barrier Via Derangement of Actin Cytoskeleton: Role of Rhoa and Rac1. Cardiovascular Research. 2011;92(2):276-86.

Daniel JM, Sedding DG. Circulating Smooth Muscle Progenitor Cells in Arterial Remodeling. Journal of Molecular and Cellular Cardiology. 2011;50(2):273-9.

2010

Hecker M, Zaslona Z, Kwapiszewska G, Niess G, Zakrzewicz A, Hergenreider E, Wilhelm J, Marsh LM, Sedding D, Klepetko W, Lohmeyer J, Dimmeler S, Seeger W, Weissmann N, Schermuly RT, Kneidinger N, Eickelberg O, Morty RE. Dysregulation of the Il-13 Receptor System a Novel Pathomechanism in Pulmonary Arterial Hypertension. American Journal of Respiratory and Critical Care Medicine. 2010;182(6):805-18.

Gunduz D, Thom J, Hussain I, Lopez D, Hartel FV, Erdogan A, Grebe M, Sedding D, Piper HM, Tillmanns H, Noll T, Aslam M. Insulin Stabilizes Microvascular Endothelial Barrier Function Via Phosphatidylinositol 3-Kinase/Akt-Mediated Rac1 Activation. Arteriosclerosis Thrombosis and Vascular Biology. 2010;30(6):1237-U363.

Kampschulte M, Brinkmann A, Stieger P, Sedding DG, Dierkes C, Bohle RM, Krombach G, Ritman EL, Langheinrich AC. Quantitative Ct Imaging of the Spatio-Temporal Distribution Patterns of Vasa Vasorum in Aortas of Apoe(-/-)/Ldl-/- Double Knockout Mice. Atherosclerosis. 2010;212(2):444-50.

Grebe MT, Luu B, Sedding D, Heidt MC, Kemkes-Matthes B, Schaefer CA, Tillmanns HH, Gunduz D. Fibrinogen Promotes Early Atherosclerotic Changes of the Carotid Artery in Young, Healthy Adults. Journal of Atherosclerosis and Thrombosis. 2010;17(10):1003-8.

Backes A, Seay U, Sedding DG, Tillmanns HH, Braun-Dullaeus RC. Inhibition of Matrix Deposition: A New Strategy for Prevention of Restenosis after Balloon Angioplasty. Journal of Cardiovascular Pharmacology. 2010;55(2):213-8.

Seeger FH, Sedding D, Langheinrich AC, Haendeler J, Zeiher AM, Dimmeler S. Inhibition of the P38 Map Kinase in Vivo Improves Number and Functional Activity of Vasculogenic Cells and Reduces Atherosclerotic Disease Progression. Basic Research in Cardiology. 2010;105(3):389-97.

Daniel JM, Bielenberg W, Stieger P, Weinert S, Tillmanns H, Sedding DG. Time-Course Analysis on the Differentiation of Bone Marrow-Derived Progenitor Cells into Smooth Muscle Cells During Neointima Formation. Arteriosclerosis Thrombosis and Vascular Biology. 2010;30(10):1890-U43.

2009

Sedding DG, Trobs M, Reich F, Walker G, Fink L, Haberbosch W, Rau W, Tillmanns H, Preissner KT, Bohle RM, Langheinrich AC. 3-Deazaadenosine Prevents Smooth Muscle Cell Proliferation and Neointima Formation by Interfering with Ras Signaling. Circulation Research. 2009;104(10):1192-U161.

Shibamiya A, Hersemeyer K, Woll TS, Sedding D, Daniel JM, Bauer S, Koyama T, Preissner KT, Kanse SM. A Key Role for Toll-Like Receptor-3 in Disrupting the Hemostasis Balance on Endothelial Cells. Blood. 2009;113(3):714-22.

Langheinrich AC, Sedding DG, Kampschulte M, Moritz R, Wilhelm J, Haberbosch WG, Ritman EL, Bohle RM. 3-Deazaadenosine Inhibits Vasa Vasorum Neovascularization in Aortas of Apoe(-/-)/Ldl-/- Double Knockout Mice. Atherosclerosis. 2009;202(1):103-10.

Seeger FH, Hess W, Sedding D, Becker G, Kinscherf R, Braun-Dullaeus RC, Viedt C, Kreuzer J. The Nucleotide Analogue 3-Deazaadenosine Prevents Neointima-Formation after Balloon Injury. Biochemical and Biophysical Research Communications. 2009;378(4):826-31.

Heidt MC, Sedding D, Stracke SKH, Stadlbauer T, Boening A, Vogt PR, Schonburg M. Measurement of Myocardial Oxygen Tension: A Valid and Sensitive Method in the Investigation of Transmyocardial Laser Revascularization in an Acute Ischemia Model. Thoracic and Cardiovascular Surgeon. 2009;57(2):79-84.

Tillmanns H, Erdogan A, Sedding D. Treatment of Chronic Cad - Do the Guidelines (Esc, Aha) Reflect Daily Practice? Herz. 2009;34(1):39-54.

2008

Parahuleva MS, Kanse SM, Parviz B, Barth A, Tillmanns H, Bohle RM, Sedding DG, Hoelschermann H. Factor Seven Activating Protease (Fsap) Expression in Human Monocytes and Accumulation in Unstable Coronary Atherosclerotic Plaques. Atherosclerosis. 2008;196(1):164-71.

Sedding DG. Foxo Transcription Factors in Oxidative Stress Response and Ageing - a New Fork on the Way to Longevity? Biological Chemistry. 2008;389(3):279-83.

Kanse SM, Parahuleva M, Muhl L, Kemkes-Matthes B, Sedding D, Preissner KT. Factor Vii-Activating Protease (Fsap): Vascular Functions and Role in Atherosclerosis. Thrombosis and Haemostasis. 2008;99(2):286-9.

Sedding DG, Homann M, Seay U, Tillmanns H, Preissner KT, Braun-Dullaeus RC. Calpain Counteracts Mechanosensitive Apoptosis of Vascular Smooth Muscle Cells in Vitro and in Vivo. Faseb Journal. 2008;22(2):579-89.

Simonis G, Wiedemann S, Schwarz K, Christ T, Sedding DG, Yu XJ, Marquetant R, Braun-Dullaeus RC, Ravens U, Strasser RH. Chelerythrine Treatment Influences the Balance of Pro- and Anti-Apoptotic Signaling Pathways in the Remote Myocardium after Infarction. Molecular and Cellular Biochemistry. 2008;310(1-2):119-28.

2007

Sedding D, Haendeler J. Do We Age on Sirt1 Expression? Circulation Research. 2007;100(10):1396-8.

Langheinrich AC, Michniewicz A, Sedding DG, Lai B, Jorgensen SM, Bohle RM, Ritman EL. Quantitative X-Ray Imaging of Intraplaque Hemorrhage in Aortas of Apoe(-/-)/Ldl(-/-) Double Knockout Mice. Investigative Radiology. 2007;42(5):263-73.

Kannemeier C, Shibamiya A, Nakazawa F, Trusheim H, Ruppert C, Markart P, Song YT, Tzima E, Kennerknecht E, Niepmann M, von Bruehl ML, Sedding D, Massberg S, Gunther A, Engelmann B, Preissner KT. Extracellular Rna Constitutes a Natural Procoagulant Cofactor in Blood Coagulation. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(15):6388-93.

Konigshoff M, Wilhelm A, Jahn A, Sedding D, Amarie OV, Eul B, Seeger W, Fink L, Gunther A, Eickelberg O, Rose F. The Angiotensin Ii Receptor 2 Is Expressed and Mediates Angiotensin Ii Signaling in Lung Fibrosis. American Journal of Respiratory Cell and Molecular Biology. 2007;37(6):640-50.

2006

Langheinrich AC, Michniewicz A, Sedding DG, Walker G, Beighley PE, Rau WS, Bohle RM, Ritman EL. Correlation of Vasa Vasorum Neovascularization and Plaque Progression in Aortas of Apolipoprotein E-/-/Low-Density Lipoprotein (-/-) Double Knockout Mice. Arteriosclerosis Thrombosis and Vascular Biology. 2006;26(2):347-52.

Sedding DG, Braun-Dullaeus RC. Caveolin-1: Dual Role for Proliferation of Vascular Smooth Muscle Cells. Trends in Cardiovascular Medicine. 2006;16(2):50-5.

Sedding D, Daniel JM, Muhl L, Hersemeyer K, Brunsch H, Kemkes-Matthes B, Braun-Dullaeus RC, Tillmanns H, Weimer T, Preissner KT, Kanse SM. The G534e Polymorphism of the Gene Encoding the Factor Vii-Activating Protease Is Associated with Cardiovascular Risk Due to Increased Neointima Formation. Journal of Experimental Medicine. 2006;203(13):2801-7.

2005

Weingartner O, Kasper M, Reynen K, Bramke S, Marquetant R, Sedding DG, Braun-Dullaeus R, Strasser RH. Comparative Morphometric and Immunohistological Assessment of the Development of Restenosis after Arterial Injury and a Cholesterol-Rich Diet in Apolipoprotein E -/- Mice and C57bl/6 Control Mice. Coronary Artery Disease. 2005;16(6):391-400.

Sedding DG, Hermsen J, Seay U, Eickelberg O, Kummer W, Schwencke C, Strasser RH, Tillmanns H, Braun-Dullaues RC. Caveolin-1 Facilitates Mechanosensitive Protein Kinase B (Akt) Signaling in Vitro and in Vivo. Circulation Research. 2005;96(6):635-42.

Seay U, Sedding D, Krick S, Hecker M, Seeger W, Eickelberg O. Transforming Growth Factor-Beta-Dependent Growth Inhibition in Primary Vascular Smooth Muscle Cells Is P38-Dependent. Journal of Pharmacology and Experimental Therapeutics. 2005;315(3):1005-12.

2004

Braun-Dullaeus RC, Mann MJ, Sedding DG, Sherwood SW, von der Leyen HE, Dzau VJ. Cell Cycle-Dependent Regulation of Smooth Muscle Cell Activation. Arteriosclerosis Thrombosis and Vascular Biology. 2004;24(5):845-50.

2003

Braun-Dullaeus RC, Dietrich S, Schoaff MJ, Sedding DG, Leithaeuser B, Walker G, Seay U, Matthias RF, Kummer W, Tillmanns H, Haberbosch W. Protective Effect of 3-Deazaadenosine in a Rat Model of Lipopolysaccharide-Induced Myocardial Dysfunction. Shock. 2003;19(3):245-51.

Sedding DG, Seay U, Fink L, Heil M, Kummer W, Tillmanns H, Braun-Dullaeus RC. Mechanosensitive P27(Kip1) Regulation and Cell Cycle Entry in Vascular Smooth Muscle Cells. Circulation. 2003;108(5):616-22.

2002

Degenhardt H, Jansen J, Schulz R, Sedding D, Braun-Dullaeus R, Schluter KD. Mechanosensitive Release of Parathyroid Hormone-Related Peptide from Coronary Endothelial Cells. American Journal of Physiology-Heart and Circulatory Physiology. 2002;283(4):H1489-H96.

Dzau VJ, Braun-Dullaeus RC, Sedding DG. Vascular Proliferation and Atherosclerosis: New Perspectives and Therapeutic Strategies. Nature Medicine. 2002;8(11):1249-56.

Unit 5.5 - miRNA in Myocardial Regeneration

2017

Viereck J, Thum T. Long Noncoding RNAs in Pathological Cardiac Remodeling. Circulation research. 2017;120(2):262-4.

Viereck J, Thum T. Circulating Noncoding RNAs as Biomarkers of Cardiovascular Disease and Injury. Circulation research. 2017;120(2):381-99.

Neumann A, Napp LC, Kleeberger JA, Benecke N, Pfanne A, Haverich A, Thum T, Bara C. MicroRNA 628-5p as a Novel Biomarker for Cardiac Allograft Vasculopathy. Transplantation. 2017;101(1):e26-e33.

2016

Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knorr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T. Stiff matrix induces switch to pure beta-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes. Basic research in cardiology. 2016;111(6):68.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T. Long noncoding RNA Chast promotes cardiac remodeling. Science translational medicine. 2016;8(326):326ra22.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease. Circulation. 2016;134(24):1973-90.

Gupta SK, Thum T. Non-coding RNAs as orchestrators of autophagic processes. Journal of molecular and cellular cardiology. 2016;95:26-30.

Gupta SK, Foinquinos A, Thum S, Remke J, Zimmer K, Bauters C, de Groote P, Boon RA, de Windt LJ, Preissl S, Hein L, Batkai S, Pinet F, Thum T. Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction. Journal of the American College of Cardiology. 2016;68(14):1557-71.

Goldschmidt I, Thum T, Baumann U. Circulating miR-21 and miR-29a as Markers of Disease Severity and Etiology in Cholestatic Pediatric Liver Disease. Journal of clinical medicine. 2016;5(3).

Fiedler J, Thum T. New Insights Into miR-17-92 Cluster Regulation and Angiogenesis. Circulation research. 2016;118(1):9-11.

Fiedler J, Gronniger E, Pfanne A, Bronneke S, Schmidt K, Falk CS, Wenck H, Terstegen L, Thum T, Winnefeld M. Identification of miR-126 as a new regulator of skin aging. Experimental dermatology. 2016.

de Gonzalo-Calvo D, Kenneweg F, Bang C, Toro R, van der Meer RW, Rijzewijk LJ, Smit JW, Lamb HJ, Llorente-Cortes V, Thum T. Circulating long-non coding RNAs as biomarkers of left ventricular diastolic function and remodelling in patients with well-controlled type 2 diabetes. Scientific reports. 2016;6:37354.

Daniel JM, Prock A, Dutzmann J, Sonnenschein K, Thum T, Bauersachs J, Sedding DG. Regulator of G-Protein Signaling 5 Prevents Smooth Muscle Cell Proliferation and Attenuates Neointima Formation. Arteriosclerosis, thrombosis, and vascular biology. 2016;36(2):317-27.

Beermann J, Piccoli MT, Viereck J, Thum T. Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches. Physiological reviews. 2016;96(4):1297-325.

Bar C, Chatterjee S, Thum T. Long Noncoding RNAs in Cardiovascular Pathology, Diagnosis, and Therapy. Circulation. 2016;134(19):1484-99.

2015

Voigtlander T, Gupta SK, Thum S, Fendrich J, Manns MP, Lankisch TO, Thum T. MicroRNAs in Serum and Bile of Patients with Primary Sclerosing Cholangitis and/or Cholangiocarcinoma. PloS one. 2015;10(10):e0139305.

Thum T. Antiageing concepts and cardiovascular disease. European heart journal. 2015;36(48):3435-6.

Sorensen-Zender I, Bhayana S, Susnik N, Rolli V, Batkai S, Baisantry A, Bahram S, Sen P, Teng B, Lindner R, Schiffer M, Thum T, Melk A, Haller H, Schmitt R. Zinc-alpha2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart. Journal of the American Society of Nephrology : JASN. 2015;26(11):2659-68.

Piccoli MT, Gupta SK, Thum T. Noncoding RNAs as regulators of cardiomyocyte proliferation and death. Journal of molecular and cellular cardiology. 2015;89(Pt A):59-67.

Lorenzen JM, Schauerte C, Kolling M, Hubner A, Knapp M, Haller H, Thum T. Long Noncoding RNAs in Urine Are Detectable and May Enable Early Detection of Acute T Cell-Mediated Rejection of Renal Allografts. Clinical chemistry. 2015;61(12):1505-14.

Fiedler J, Breckwoldt K, Remmele CW, Hartmann D, Dittrich M, Pfanne A, Just A, Xiao K, Kunz M, Muller T, Hansen A, Geffers R, Dandekar T, Eschenhagen T, Thum T. Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization. Journal of the American College of Cardiology. 2015;66(18):2005-15.

Bang C, Antoniades C, Antonopoulos AS, Eriksson U, Franssen C, Hamdani N, Lehmann L, Moessinger C, Mongillo M, Muhl L, Speer T, Thum T. Intercellular communication lessons in heart failure. European journal of heart failure. 2015;17(11):1091-103.

Lorenzen JM, Schauerte C, Kielstein JT, Hubner A, Martino F, Fiedler J, Gupta SK, Faulhaber-Walter R, Kumarswamy R, Hafer C, Haller H, Fliser D, Thum T. Circulating Long Noncoding Rnatapsaki Is a Predictor of Mortality in Critically Ill Patients with Acute Kidney Injury. Clin Chem. 2015;61(1):191-201. Epub 2014/10/09.

Mayer SC, Gilsbach R, Preissl S, Monroy Ordonez EB, Schnick T, Beetz N, Lother A, Rommel C, Ihle H, Bugger H, Ruhle F, Schrepper A, Schwarzer M, Heilmann C, Bonisch U, Gupta SK, Wilpert J, Kretz O, von Elverfeldt D, Orth J, Aktories K, Beyersdorf F, Bode C, Stiller B, Kruger M, Thum T, Doenst T, Stoll M, Hein L. Adrenergic Repression of the Epigenetic Reader Mecp2 Facilitates Cardiac Adaptation in Chronic Heart Failure. Circ Res. 2015;117(7):622-33. Epub 2015/07/22.

Varga ZV, Giricz Z, Bencsik P, Madonna R, Gyongyosi M, Schulz R, Mayr M, Thum T, Puskas LG, Ferdinandy P. Functional Genomics of Cardioprotection by Ischemic Conditioning and the Influence of Comorbid Conditions: Implications in Target Identification. Curr Drug Targets. 2015;16(8):904-11. Epub 2015/04/29.

Thum T. Antiageing Concepts and Cardiovascular Disease. Eur Heart J. 2015. Epub 2015/08/22.

Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bahre H, Kaever V, Thum T, Bauersachs J, Heineke J. Antiandrogenic Therapy with Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction. Circulation. 2015;131(12):1071-81. Epub 2015/01/30.

Bantel H, Thum T, Schulze-Osthoff K. Reply: To Pmid 24913549. Hepatology. 2015;61(4):1440-1.

Derda AA, Thum S, Lorenzen JM, Bavendiek U, Heineke J, Keyser B, Stuhrmann M, Givens RC, Kennel PJ, Schulze PC, Widder JD, Bauersachs J, Thum T. Blood-Based Microrna Signatures Differentiate Various Forms of Cardiac Hypertrophy. Int J Cardiol. 2015;196:115-22. Epub 2015/06/19.

Sorensen-Zender I, Bhayana S, Susnik N, Rolli V, Batkai S, Baisantry A, Bahram S, Sen P, Teng B, Lindner R, Schiffer M, Thum T, Melk A, Haller H, Schmitt R. Zinc-Alpha2-Glycoprotein Exerts Antifibrotic Effects in Kidney and Heart. J Am Soc Nephrol. 2015;26(11):2659-68. Epub 2015/03/20.

Heymans S, Gonzalez A, Pizard A, Papageorgiou AP, Lopez-Andres N, Jaisser F, Thum T, Zannad F, Diez J. Searching for New Mechanisms of Myocardial Fibrosis with Diagnostic and/or Therapeutic Potential. Eur J Heart Fail. 2015;17(8):764-71. Epub 2015/07/02.

Dangwal S, Stratmann B, Bang C, Lorenzen JM, Kumarswamy R, Fiedler J, Falk CS, Scholz CJ, Thum T, Tschoepe D. Impairment of Wound Healing in Patients with Type 2 Diabetes Mellitus Influences Circulating Microrna Patterns Via Inflammatory Cytokines. Arterioscler Thromb Vasc Biol. 2015;35(6):1480-8. Epub 2015/03/31.

Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J. Enabling [(18)F]-Bicyclo[6.1.0]Nonyne for Oligonucleotide Conjugation for Positron Emission Tomography Applications: [(18)F]-Anti-Microrna-21 as an Example. Chem Commun (Camb). 2015;51(48):9821-4. Epub 2015/05/20.

Watson CJ, Gupta SK, O’Connell E, Thum S, Glezeva N, Fendrich J, Gallagher J, Ledwidge M, Grote-Levi L, McDonald K, Thum T. Microrna Signatures Differentiate Preserved from Reduced Ejection Fraction Heart Failure. Eur J Heart Fail. 2015;17(4):405-15. Epub 2015/03/06.

Bang C, Antoniades C, Antonopoulos AS, Eriksson U, Franssen C, Hamdani N, Lehmann L, Moessinger C, Mongillo M, Muhl L, Speer T, Thum T. Intercellular Communication Lessons in Heart Failure. Eur J Heart Fail. 2015. Epub 2015/09/24.

Voigtlander T, Gupta SK, Thum S, Fendrich J, Manns MP, Lankisch TO, Thum T. Micrornas in Serum and Bile of Patients with Primary Sclerosing Cholangitis and/or Cholangiocarcinoma. PLoS One. 2015;10(10):e0139305. Epub 2015/10/03.

Piccoli MT, Gupta SK, Thum T. Noncoding Rnas as Regulators of Cardiomyocyte Proliferation and Death. J Mol Cell Cardiol. 2015. Epub 2015/02/11.

Hirt MN, Werner T, Indenbirken D, Alawi M, Demin P, Kunze AC, Stenzig J, Starbatty J, Hansen A, Fiedler J, Thum T, Eschenhagen T. Deciphering the Microrna Signature of Pathological Cardiac Hypertrophy by Engineered Heart Tissue- and Sequencing-Technology. J Mol Cell Cardiol. 2015;81:1-9. Epub 2015/01/31.

Ahlbrecht J, Martino F, Pul R, Skripuletz T, Suhs KW, Schauerte C, Yildiz O, Trebst C, Tasto L, Thum S, Pfanne A, Roesler R, Lauda F, Hecker M, Zettl UK, Tumani H, Thum T, Stangel M. Deregulation of Microrna-181c in Cerebrospinal Fluid of Patients with Clinically Isolated Syndrome Is Associated with Early Conversion to Relapsing-Remitting Multiple Sclerosis. Mult Scler. 2015. Epub 2015/10/24.

Thum T, Condorelli G. Long Noncoding Rnas and Micrornas in Cardiovascular Pathophysiology. Circ Res. 2015;116(4):751-62. Epub 2015/02/14.

Fiedler J, Breckwoldt K, Remmele CW, Hartmann D, Dittrich M, Pfanne A, Just A, Xiao K, Kunz M, Muller T, Hansen A, Geffers R, Dandekar T, Eschenhagen T, Thum T. Development of Long Noncoding Rna-Based Strategies to Modulate Tissue Vascularization. J Am Coll Cardiol. 2015;66(18):2005-15.

Viereck J, Kumarswamy R, Thum T. Long Noncoding Rnas as Inducers and Terminators of Vascular Development. Circulation. 2015;131(14):1236-8. Epub 2015/03/06.

Devaux Y, Zangrando J, Schroen B, Creemers EE, Pedrazzini T, Chang CP, Dorn GW, 2nd, Thum T, Heymans S. Long Noncoding Rnas in Cardiac Development and Ageing. Nat Rev Cardiol. 2015;12(7):415-25. Epub 2015/04/10.

Lorenzen JM, Schauerte C, Kolling M, Hubner A, Knapp M, Haller H, Thum T. Long Noncoding Rnas in Urine Are Detectable and May Enable Early Detection of Acute T Cell-Mediated Rejection of Renal Allografts. Clin Chem. 2015. Epub 2015/10/29.

Van Aelst LN, Summer G, Li S, Gupta SK, Heggermont W, De Vusser K, Carai P, Naesens M, Van Cleemput J, Van de Werf F, Vanhaecke J, Thum T, Waer M, Papageorgiou AP, Schroen B, Heymans S. Rna Profiling in Human and Murine Transplanted Hearts: Identification and Validation of Therapeutic Targets for Acute Cardiac and Renal Allograft Rejection. Am J Transplant. 2015. Epub 2015/08/08.

Lorenzen JM, Schauerte C, Hubner A, Kolling M, Martino F, Scherf K, Batkai S, Zimmer K, Foinquinos A, Kaucsar T, Fiedler J, Kumarswamy R, Bang C, Hartmann D, Gupta SK, Kielstein J, Jungmann A, Katus HA, Weidemann F, Muller OJ, Haller H, Thum T. Osteopontin Is Indispensible for Ap1-Mediated Angiotensin Ii-Related Mir-21 Transcription During Cardiac Fibrosis. Eur Heart J. 2015;36(32):2184-96. Epub 2015/04/23.

2014

Batkai S, Thum T. Analytical Approaches in Microrna Therapeutics. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;964:146-52.

Kunz M, Xiao K, Liang C, Viereck J, Pachel C, Frantz S, Thum T, Dandekar T. Bioinformatics of Cardiovascular Mirna Biology. J Mol Cell Cardiol. 2014.

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac Fibroblast-Derived Microrna Passenger Strand-Enriched Exosomes Mediate Cardiomyocyte Hypertrophy. J Clin Invest. 2014;124(5):2136-46. Epub 2014/04/20.

Sassi Y, Ahles A, Truong DJ, Baqi Y, Lee SY, Husse B, Hulot JS, Foinquinos A, Thum T, Muller CE, Dendorfer A, Laggerbauer B, Engelhardt S. Cardiac Myocyte-Secreted Camp Exerts Paracrine Action Via Adenosine Receptor Activation. J Clin Invest. 2014;124(12):5385-97.

Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, de Groote P, Pinet F, Thum T. Circulating Long Noncoding Rna, Lipcar, Predicts Survival in Patients with Heart Failure. Circ Res. 2014;114(10):1569-75.

Mooren FC, Viereck J, Kruger K, Thum T. Circulating Micrornas as Potential Biomarkers of Aerobic Exercise Capacity. Am J Physiol Heart Circ Physiol. 2014;306(4):H557-63.

Morley-Smith AC, Mills A, Jacobs S, Meyns B, Rega F, Simon AR, Pepper JR, Lyon AR, Thum T. Circulating Micrornas for Predicting and Monitoring Response to Mechanical Circulatory Support from a Left Ventricular Assist Device. Eur J Heart Fail. 2014;16(8):871-9.

Thum T. Noncoding Rnas and Myocardial Fibrosis. Nat Rev Cardiol. 2014;11(11):655-63.

33.

Thum T, Batkai S. Micrornas in Right Ventricular (Dys)Function (2013 Grover Conference Series). Pulm Circ. 2014;4(2):185-90.

Lorenzen JM, Kaucsar T, Schauerte C, Schmitt R, Rong S, Hubner A, Scherf K, Fiedler J, Martino F, Kumarswamy R, Kolling M, Sorensen I, Hinz H, Heineke J, van Rooij E, Haller H, Thum T. Microrna-24 Antagonism Prevents Renal Ischemia Reperfusion Injury. J Am Soc Nephrol. 2014;25(12):2717-29.

Osipova J, Fischer DC, Dangwal S, Volkmann I, Widera C, Schwarz K, Lorenzen JM, Schreiver C, Jacoby U, Heimhalt M, Thum T, Haffner D. Diabetes-Associated Micrornas in Pediatric Patients with Type 1 Diabetes Mellitus: A Cross-Sectional Cohort Study. J Clin Endocrinol Metab. 2014;99(9):E1661-5.

John K, Hadem J, Krech T, Wahl K, Manns MP, Dooley S, Batkai S, Thum T, Schulze-Osthoff K, Bantel H. Micrornas Play a Role in Spontaneous Recovery from Acute Liver Failure. Hepatology. 2014;60(4):1346-55.

Radke RM, Diller GP, Duck M, Orwat S, Hartmann D, Thum T, Baumgartner H. Endothelial Function in Contemporary Patients with Repaired Coarctation of Aorta. Heart. 2014;100(21):1696-701.

Leite-Moreira AF, Lourenco AP, Balligand JL, Bauersachs J, Clerk A, De Windt LJ, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Kaminski KA, Knoll R, Mayr M, Tarone G, Thum T, Tocchetti CG. Esc Working Group on Myocardial Function Position Paper: How to Study the Right Ventricle in Experimental Models. European Journal of Heart Failure. 2014;16(5):509-18.

Dangwal S, Thum T. Microrna Therapeutics in Cardiovascular Disease Models. Annu Rev Pharmacol Toxicol. 2014;54:185-203.

Fiedler J, Stohr A, Gupta SK, Hartmann D, Holzmann A, Just A, Hansen A, Hilfiker-Kleiner D, Eschenhagen T, Thum T. Functional Microrna Library Screening Identifies the Hypoxamir Mir-24 as a Potent Regulator of Smooth Muscle Cell Proliferation and Vascularization. Antioxidants & Redox Signaling. 2014;21(8):1167-76.

Hirsch E, Nagai R, Thum T. Heterocellular Signalling and Crosstalk in the Heart in Ischaemia and Heart Failure. Cardiovasc Res. 2014;102(2):191-3.

Winkler C, Bahlmann O, Viereck J, Knudsen L, Wedekind D, Hoymann HG, Madsen J, Thum T, Hohlfeld JM, Ochs M. Impact of a Met(11)Thr Single Nucleotide Polymorphism of Surfactant Protein D on Allergic Airway Inflammation in a Murine Asthma Model. Exp Lung Res. 2014;40(4):154-63.

Blecharz KG, Burek M, Bauersachs J, Thum T, Tsikas D, Widder J, Roewer N, Forster CY. Inhibition of Proteasome-Mediated Glucocorticoid Receptor Degradation Restores Nitric Oxide Bioavailability in Myocardial Endothelial Cells in Vitro. Biol Cell. 2014;106(7):219-35.

Trettin A, Modun D, Madunic S, Vukovic J, Radman M, Batkai S, Thum T, Jordan J, Tsikas D. Lc-Ms/Ms and Gc-Ms/Ms Measurement of Plasma and Urine Di-Paracetamol and 3-Nitro-Paracetamol: Proof-of-Concept Studies on a Novel Human Model of Oxidative Stress Based on Oral Paracetamol Administration. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;959:71-81.

Thum T, Fiedler J. Lincing Malat1 and Angiogenesis. Circ Res. 2014;114(9):1366-8.

Lankisch TO, Voigtlander T, Manns MP, Holzmann A, Dangwal S, Thum T. Micrornas in the Bile of Patients with Biliary Strictures after Liver Transplantation. Liver Transpl. 2014;20(6):673-8.

Thum T. Non-Coding Rnas in Ageing. Ageing Res Rev. 2014;17:1-2.

Fiedler J, Batkai S, Thum T. Microrna-Based Therapy in Cardiology. Herz. 2014;39(2):194-200.

Gupta SK, Piccoli MT, Thum T. Non-Coding Rnas in Cardiovascular Ageing. Ageing Res Rev. 2014;17:79-85.

Rayner K, Dimmeler S, Calin GA, Thum T, Raizman JE, Diamandis EP. Novel Biomarkers for Acute Myocardial Infarction: Is Microrna the New Kid on the Block? Clin Chem. 2014;60(6):812-7.

Springer J, Tschirner A, Haghikia A, von Haehling S, Lal H, Grzesiak A, Kaschina E, Palus S, Potsch M, von Websky K, Hocher B, Latouche C, Jaisser F, Morawietz L, Coats AJ, Beadle J, Argiles JM, Thum T, Foldes G, Doehner W, Hilfiker-Kleiner D, Force T, Anker SD. Prevention of Liver Cancer Cachexia-Induced Cardiac Wasting and Heart Failure. Eur Heart J. 2014;35(14):932-41.

Jaguszewski M, Osipova J, Ghadri JR, Napp LC, Widera C, Franke J, Fijalkowski M, Nowak R, Fijalkowska M, Volkmann I, Katus HA, Wollert KC, Bauersachs J, Erne P, Lscher TF, Thum T, Templin C. A Signature of Circulating Micrornas Differentiates Takotsubo Cardiomyopathy from Acute Myocardial Infarction. European Heart Journal. 2014;35(15):999-+.

Viereck J, Bang C, Foinquinos A, Thum T. Regulatory Rnas and Paracrine Networks in the Heart. Cardiovasc Res. 2014;102(2):290-301.

Varga ZV, Zvara A, Farago N, Kocsis GF, Pipicz M, Gaspar R, Bencsik P, Gorbe A, Csonka C, Puskas LG, Thum T, Csont T, Ferdinandy P. Micrornas Associated with Ischemia-Reperfusion Injury and Cardioprotection by Ischemic Pre- and Postconditioning: Protectomirs. Am J Physiol Heart Circ Physiol. 2014;307(2):H216-27.

Thum T, Kumarswamy R. The Smooth Long Noncoding Rna Sencr. Arterioscler Thromb Vasc Biol. 2014;34(6):1124-5.

Tarone G, Balligand JL, Bauersachs J, Clerk A, De Windt L, Heymans S, Hilfiker-Kleiner D, Hirsch E, Iaccarino G, Knoll R, Leite-Moreira AF, Lourenco AP, Mayr M, Thum T, Tocchetti CG. Targeting Myocardial Remodelling to Develop Novel Therapies for Heart Failure a Position Paper from the Working Group on Myocardial Function of the European Society of Cardiology. European Journal of Heart Failure. 2014;16(5):494-508.

Batkai S, Thum T. Towards Novel Theranostic Approaches in Cardiac Transplantation Medicine. Eur Heart J. 2014;35(45):3152-4.

Trettin A, Batkai S, Thum T, Jordan J, Tsikas D. Trapping of Napqi, the Intermediate Toxic Paracetamol Metabolite, by Aqueous Sulfide (S(2)(-)) and Analysis by Gc-Ms/Ms. J Chromatogr B Analyt Technol Biomed Life Sci. 2014;963:99-105.

Kumarswamy R, Volkmann I, Beermann J, Napp LC, Jabs O, Bhayadia R, Melk A, Ucar A, Chowdhury K, Lorenzen JM, Gupta SK, Batkai S, Thum T. Vascular Importance of the Mir-212/132 Cluster. Eur Heart J. 2014;35(45):3224-31.

2013

Tutarel O, Dangwal S, Bretthauer J, Westhoff-Bleck M, Roentgen P, Anker SD, Bauersachs J, Thum T. Circulating Mir-423_5p Fails as a Biomarker for Systemic Ventricular Function in Adults after Atrial Repair for Transposition of the Great Arteries. Int J Cardiol. 2013;167(1):63-6.

Lorenzen JM, Martino F, Thum T. Detection and Transport Mechanisms of Circulating Micrornas in Neurological, Cardiac and Kidney Diseases. Curr Med Chem. 2013;20(29):3623-8. Epub 2013/07/10.

Kaucsar T, Revesz C, Godo M, Krenacs T, Albert M, Szalay CI, Rosivall L, Benyo Z, Batkai S, Thum T, Szenasi G, Hamar P. Activation of the Mir-17 Family and Mir-21 During Murine Kidney Ischemia-Reperfusion Injury. Nucleic Acid Ther. 2013;23(5):344-54.

Heymans S, Corsten MF, Verhesen W, Carai P, van Leeuwen RE, Custers K, Peters T, Hazebroek M, Stoger L, Wijnands E, Janssen BJ, Creemers EE, Pinto YM, Grimm D, Schurmann N, Vigorito E, Thum T, Stassen F, Yin X, Mayr M, de Windt LJ, Lutgens E, Wouters K, de Winther MP, Zacchigna S, Giacca M, van Bilsen M, Papageorgiou AP, Schroen B. Macrophage Microrna-155 Promotes Cardiac Hypertrophy and Failure. Circulation. 2013;128(13):1420-32.

Volkmann I, Kumarswamy R, Pfaff N, Fiedler J, Dangwal S, Holzmann A, Batkai S, Geffers R, Lother A, Hein L, Thum T. Microrna-Mediated Epigenetic Silencing of Sirtuin1 Contributes to Impaired Angiogenic Responses. Circ Res. 2013;113(8):997-1003.

Lorenzen JM, Dietrich B, Fiedler J, Jazbutyte V, Fleissner F, Karpinski N, Weidemann F, Wanner C, Asan E, Caprio M, Ertl G, Bauersachs J, Thum T. Pathologic Endothelial Response and Impaired Function of Circulating Angiogenic Cells in Patients with Fabry Disease. Basic Res Cardiol. 2013;108(1):311.

Jazbutyte V, Fiedler J, Kneitz S, Galuppo P, Just A, Holzmann A, Bauersachs J, Thum T. Microrna-22 Increases Senescence and Activates Cardiac Fibroblasts in the Aging Heart. Age (Dordr). 2013;35(3):747-62.

Thum T. Microrna-223 Made Its Way into Vascular Research. Circ Res. 2013;113(12):1270-1.

Lorenzen JM, Batkai S, Thum T. Regulation of Cardiac and Renal Ischemia-Reperfusion Injury by Micrornas. Free Radic Biol Med. 2013;64:78-84.

Fiedler J, Thum T. Micrornas in Myocardial Infarction. Arterioscler Thromb Vasc Biol. 2013;33(2):201-5.

Dangwal S, Thum T. Micrornas in Platelet Physiology and Pathology. Hamostaseologie. 2013;33(1):17-20.

Lorenzen JM, Thum T. Micrornas in Idiopathic Childhood Nephrotic Syndrome. Clin Chem. 2013;59(4):595-7.

Kumarswamy R, Thum T. Non-Coding Rnas in Cardiac Remodeling and Heart Failure. Circ Res. 2013;113(6):676-89.

Diekmann U, Elsner M, Fiedler J, Thum T, Lenzen S, Naujok O. Microrna Target Sites as Genetic Tools to Enhance Promoter-Reporter Specificity for the Purification of Pancreatic Progenitor Cells from Differentiated Embryonic Stem Cells. Stem Cell Rev. 2013;9(5):555-68.

Bauters C, Kumarswamy R, Holzmann A, Bretthauer J, Anker SD, Pinet F, Thum T. Circulating Mir-133a and Mir-423-5p Fail as Biomarkers for Left Ventricular Remodeling after Myocardial Infarction. Int J Cardiol. 2013;168(3):1837-40.

Ganesan J, Ramanujam D, Sassi Y, Ahles A, Jentzsch C, Werfel S, Leierseder S, Loyer X, Giacca M, Zentilin L, Thum T, Laggerbauer B, Engelhardt S. Mir-378 Controls Cardiac Hypertrophy by Combined Repression of Mitogen-Activated Protein Kinase Pathway Factors. Circulation. 2013;127(21):2097-106.

Emanueli C, Thum T. Mirnage-34 Induces Cardiac Damage. Cell Res. 2013;23(7):866-7.

Baumgarten A, Bang C, Tschirner A, Engelmann A, Adams V, von Haehling S, Doehner W, Pregla R, Anker MS, Blecharz K, Meyer R, Hetzer R, Anker SD, Thum T, Springer J. Twist1 Regulates the Activity of Ubiquitin Proteasome System Via the Mir-199/214 Cluster in Human End-Stage Dilated Cardiomyopathy. Int J Cardiol. 2013;168(2):1447-52.

Dirkx E, Gladka MM, Philippen LE, Armand AS, Kinet V, Leptidis S, El Azzouzi H, Salic K, Bourajjaj M, da Silva GJ, Olieslagers S, van der Nagel R, de Weger R, Bitsch N, Kisters N, Seyen S, Morikawa Y, Chanoine C, Heymans S, Volders PG, Thum T, Dimmeler S, Cserjesi P, Eschenhagen T, da Costa Martins PA, De Windt LJ. Nfat and Mir-25 Cooperate to Reactivate the Transcription Factor Hand2 in Heart Failure. Nat Cell Biol. 2013;15(11):1282-93.

2012

Bang C, Thum T. Exosomes: New Players in Cell-Cell Communication. Int J Biochem Cell Biol. 2012;44(11):2060-4.

Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, Kumarswamy R, Bang C, Holzmann A, Remke J, Caprio M, Jentzsch C, Engelhardt S, Geisendorf S, Glas C, Hofmann TG, Nessling M, Richter K, Schiffer M, Carrier L, Napp LC, Bauersachs J, Chowdhury K, Thum T. The Mirna-212/132 Family Regulates Both Cardiac Hypertrophy and Cardiomyocyte Autophagy. Nature Communications. 2012;3.

Dangwal S, Hartmann D, Thum T. Micrornas Deciding Cardiac Stem Cell Fate. J Mol Cell Cardiol. 2012;53(6):747-8.

Pfaff N, Moritz T, Thum T, Cantz T. Mirnas Involved in the Generation, Maintenance, and Differentiation of Pluripotent Cells. Journal of Molecular Medicine. 2012;90(7):747-52.

Kumarswamy R, Lyon AR, Volkmann I, Mills AM, Bretthauer J, Pahuja A, Geers-Knorr C, Kraft T, Hajjar RJ, Macleod KT, Harding SE, Thum T. Serca2a Gene Therapy Restores Microrna-1 Expression in Heart Failure Via an Akt/Foxo3a-Dependent Pathway. Eur Heart J. 2012;33(9):1067-75.

Haghikia A, Haghikia A, Hellwig K, Baraniskin A, Holzmann A, Decard BF, Thum T, Gold R. Regulated Micrornas in the Csf of Patients with Multiple Sclerosis: A Case-Control Study. Neurology. 2012;79(22):2166-70.

2011

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T. Mirna Screening Reveals a New Mirna Family Stimulating Ips Cell Generation Via Regulation of Meox2. EMBO Rep. 2011;12(11):1153-9.

Fiedler J, Jazbutyte V, Kirchmaier BC, Gupta SK, Lorenzen J, Hartmann D, Galuppo P, Kneitz S, Pena JTG, Sohn-Lee C, Loyer X, Soutschek J, Brand T, Tuschl T, Heineke J, Martin U, Schulte-Merker S, Ertl G, Engelhardt S, Bauersachs J, Thum T. Microrna-24 Regulates Vascularity after Myocardial Infarction. Circulation. 2011;124(6):720-U178.

Unit 5.6 - Tissue Engineered Valves

2016

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Hoffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016;49(4):1228-38.

Theodoridis K, Muller J, Ramm R, Findeisen K, Andree B, Korossis S, Haverich A, Hilfiker A. Effects of combined cryopreservation and decellularization on the biomechanical, structural and biochemical properties of porcine pulmonary heart valves. Acta biomaterialia. 2016;43:71-7.

Ramm R, Niemann H, Petersen B, Haverich A, Hilfiker A. Decellularized GGTA1-KO pig heart valves do not bind preformed human xenoantibodies. Basic research in cardiology. 2016;111(4):39.

Aper T, Wilhelmi M, Gebhardt C, Hoeffler K, Benecke N, Hilfiker A, Haverich A. Novel method for the generation of tissue-engineered vascular grafts based on a highly compacted fibrin matrix. Acta biomaterialia. 2016;29:21-32.

2015

Wolkers WF, Hilfiker A. Freeze-Drying of Decellularized Heart Valve Tissues. Methods Mol Biol. 2015;1257:499-506.

Wang S, Oldenhof H, Goecke T, Ramm R, Harder M, Haverich A, Hilfiker A, Wolkers WF. Sucrose Diffusion in Decellularized Heart Valves for Freeze-Drying. Tissue Eng Part C Methods. 2015;21(9):922-31.

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Hoffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized Aortic Allografts Versus Pulmonary Autografts for Aortic Valve Replacement in the Growing Sheep Model: Haemodynamic and Morphological Results at 20 Months after Implantation. Eur J Cardiothorac Surg. 2015.

Theodoridis K, Tudorache I, Calistru A, Cebotari S, Meyer T, Sarikouch S, Bara C, Brehm R, Haverich A, Hilfiker A. Successful Matrix Guided Tissue Regeneration of Decellularized Pulmonary Heart Valve Allografts in Elderly Sheep. Biomaterials. 2015;52:221-8.

Ramm R, Hartmann T, Tudorache I, Haverich A, Hilfiker A. No Evidence for Alphagal Epitope Transfer from Media Containing Fcs onto Human Endothelial Cells in Culture. Xenotransplantation. 2015;22(5):345-55.

Lux M, Andree B, Horvath T, Nosko A, Manikowski D, Hilfiker-Kleiner D, Haverich A, Hilfiker A. In Vitro Maturation of Large-Scale Cardiac Patches Based on a Perfusable Starter Matrix by Cyclic Mechanical Stimulation. Acta Biomater. 2015.

Iablonskii P, Cebotari S, Tudorache I, Granados M, Morticelli L, Goecke T, Klein N, Korossis S, Hilfiker A, Haverich A. Tissue-Engineered Mitral Valve: Morphology and Biomechanics Dagger. Interact Cardiovasc Thorac Surg. 2015;20(6):712-9; discussion 9.

Hofmann AD, Hilfiker A, Haverich A, Andree B, Kuebler J, Ure B. Biovam in the Rat Model: A New Approach of Vascularized 3d Tissue for Esophageal Replacement. Eur J Pediatr Surg. 2015;25(2):181-8.

Goecke T, Tudorache I, Hilfiker A, Haverich A, Cebotari S. [Prefabrication of Heart Valves]. Chirurg. 2015;86(3):251-3. Prafabrikation von Herzklappen.

Goecke T, Hilfiker A, Haverich A, Cebotari S. Investigation of Inflammatory Response of Decellularized Porcine Aortic Tissue in Mice: Can We Rely on This Experimental Setting? Eur J Cardiothorac Surg. 2015;47(3):e90-1. Epub 2014/12/30.

Aper T, Wilhelmi M, Gebhardt C, Hoeffler K, Benecke N, Hilfiker A, Haverich A. Novel Method for the Generation of Tissue-Engineered Vascular Grafts Based on a Highly Compacted Fibrin Matrix. Acta Biomater. 2015.

2014

Wang S, Oldenhof H, Dai X, Haverich A, Hilfiker A, Harder M, Wolkers WF. Protein Stability in Stored Decellularized Heart Valve Scaffolds and Diffusion Kinetics of Protective Molecules. Biochim Biophys Acta. 2014;1844(2):430-8.

Vukadinovic-Nikolic Z, Andree B, Dorfman SE, Pflaum M, Horvath T, Lux M, Venturini L, Bar A, Kensah G, Lara AR, Tudorache I, Cebotari S, Hilfiker-Kleiner D, Haverich A, Hilfiker A. Generation of Bioartificial Heart Tissue by Combining a Three-Dimensional Gel-Based Cardiac Construct with Decellularized Small Intestinal Submucosa. Tissue Engineering Part A. 2014;20(3-4):799-809.

Minol JP, Baraki H, Akhyari P, Bagaev E, Suprunov M, Brandes G, Bara C, Hort W, Hurschler C, Sigler M, Haverich A, Hilfiker A, Lichtenberg A. Tracheal Cartilage - Evaluating the Potential of a Novel Biomaterial for Reconstructive Cardiovascular Procedures. J Tissue Eng Regen Med. 2014;8(11):850-61.

Melk A, Tegtbur U, Hilfiker-Kleiner D, Eberhard J, Saretzki G, Eulert C, Kerling A, Nelius AK, Homme M, Strunk D, Berliner D, Rontgen P, Kuck M, Bauersachs J, Hilfiker A, Haverich A, Bara C, Stiesch M. Improvement of Biological Age by Physical Activity. International Journal of Cardiology. 2014;176(3):1187-9.

Hochberger J, Koehler P, Wedi E, Gluer S, Rothstein RI, Niemann H, Hilfiker A, Gonzalez S, Kruse E. Transplantation of Mucosa from Stomach to Esophagus to Prevent Stricture after Circumferential Endoscopic Submucosal Dissection of Early Squamous Cell. Gastroenterology. 2014;146(4):906-9.

Eberhard J, Stiesch M, Kerling A, Bara C, Eulert C, Hilfiker-Kleiner D, Hilfiker A, Budde E, Bauersachs J, Kuck M, Haverich A, Melk A, Tegtbur U. Moderate and Severe Periodontitis Are Independent Risk Factors Associated with Low Cardiorespiratory Fitness in Sedentary Non-Smoking Men Aged between 45 and 65 Years. J Clin Periodontol. 2014;41(1):31-7.

Andree B, Bela K, Horvath T, Lux M, Ramm R, Venturini L, Ciubotaru A, Zweigerdt R, Haverich A, Hilfiker A. Successful Re-Endothelialization of a Perfusable Biological Vascularized Matrix (Biovam) for the Generation of 3d Artificial Cardiac Tissue. Basic Res Cardiol. 2014;109(6):441.

2013

Westhoff-Bleck M, Podewski E, Hilfiker A, Hilfiker-Kleiner D. Cardiovascular Disorders in Pregnancy: Diagnosis and Management. Best Practice & Research Clinical Obstetrics & Gynaecology. 2013;27(6):821-34.

Tudorache I, Calistru A, Baraki H, Meyer T, Hoffler K, Sarikouch S, Bara C, Gorler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic Replacement of Aortic Heart Valves with Tissue-Engineered Grafts. Tissue Eng Part A. 2013;19(15-16):1686-94.

Steele TW, Huang CL, Nguyen E, Sarig U, Kumar S, Widjaja E, Loo JS, Machluf M, Boey F, Vukadinovic Z, Hilfiker A, Venkatraman SS. Collagen-Cellulose Composite Thin Films That Mimic Soft-Tissue and Allow Stem-Cell Orientation. J Mater Sci Mater Med. 2013;24(8):2013-27.

Schilling T, Brandes G, Tudorache I, Cebotari S, Hilfiker A, Meyer T, Biskup C, Bauer M, Waldmann KH, Bach FW, Haverich A, Hassel T. In Vivo Degradation of Magnesium Alloy La63 Scaffolds for Temporary Stabilization of Biological Myocardial Grafts in a Swine Model. Biomed Tech (Berl). 2013;58(5):407-16.

Derks M, Sturm T, Haverich A, Hilfiker A. Isolation and Chondrogenic Differentiation of Porcine Perichondrial Progenitor Cells for the Purpose of Cartilage Tissue Engineering. Cells Tissues Organs. 2013;198(3):179-89.

Ciubotaru A, Cebotari S, Tudorache I, Beckmann E, Hilfiker A, Haverich A. Biological Heart Valves. Biomed Tech (Berl). 2013;58(5):389-97.

Aper T, Teebken OE, Kruger A, Heisterkamp A, Hilfiker A, Haverich A. Development of Implantable Autologous Small-Calibre Vascular Grafts from Peripheral Blood Samples. Zentralbl Chir. 2013;138(2):173-9.

Andree B, Bar A, Haverich A, Hilfiker A. Small Intestinal Submucosa Segments as Matrix for Tissue Engineering: Review. Tissue Eng Part B Rev. 2013;19(4):279-91.

2012

Wang S, Goecke T, Meixner C, Haverich A, Hilfiker A, Wolkers WF. Freeze-Dried Heart Valve Scaffolds. Tissue Eng Part C Methods. 2012;18(7):517-25.

Unit 5.7 - Myocardial Tissue Engineering

2016

Dibbert N, Krause A, Rios-Camacho JC, Gruh I, Kirschning A, Drager G. A Synthetic Toolbox for the In Situ Formation of Functionalized Homo- and Heteropolysaccharide-Based Hydrogel Libraries. Chemistry. 2016;22(52):18777-86.

2015

Lachmann N, Brennig S, Hillje R, Schermeier H, Phaltane R, Dahlmann J, Gruh I, Heinz N, Schiedlmeier B, Baum C, Moritz T. Tightly regulated 'all-in-one' lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy. Gene therapy. 2015;22(11):883-92.

Lachmann N, Brennig S, Hillje R, Schermeier H, Phaltane R, Dahlmann J, Gruh I, Heinz N, Schiedlmeier B, Baum C, Moritz T. Tightly Regulated 'All-in-One' Lentiviral Vectors for Protection of Human Hematopoietic Cells from Anticancer Chemotherapy. Gene Ther. 2015;22(11):883-92. Epub 2015/07/01.

2014

Zweigerdt R, Gruh I, Martin U. Your Heart on a Chip: Ipsc-Based Modeling of Barth-Syndrome-Associated Cardiomyopathy. Cell Stem Cell. 2014;15(1):9-11.

Vukadinovic-Nikolic Z, Andree B, Dorfman SE, Pflaum M, Horvath T, Lux M, Venturini L, Bar A, Kensah G, Lara AR, Tudorache I, Cebotari S, Hilfiker-Kleiner D, Haverich A, Hilfiker A. Generation of Bioartificial Heart Tissue by Combining a Three-Dimensional Gel-Based Cardiac Construct with Decellularized Small Intestinal Submucosa. Tissue Eng Part A. 2014;20(3-4):799-809.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Kempf H, Olmer R, Kropp C, Ruckert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Stem Cell Reports. 2014;3(6):1132-46.

2013

Lachmann N, Brennig S, Pfaff N, Schermeier H, Dahlmann J, Phaltane R, Gruh I, Modlich U, Schambach A, Baum C, Moritz T. Efficient in Vivo Regulation of Cytidine Deaminase Expression in the Haematopoietic System Using a Doxycycline-Inducible Lentiviral Vector System. Gene Ther. 2013;20(3):298-307.

Kensah G, Roa Lara A, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Drager G, Ochs M, Haverich A, Gruh I, Martin U. Murine and Human Pluripotent Stem Cell-Derived Cardiac Bodies Form Contractile Myocardial Tissue in Vitro. Eur Heart J. 2013;34(15):1134-46.

Emmert MY, Emmert LS, Martens A, Ismail I, Schmidt-Richter I, Gawol A, Seifert B, Haverich A, Martin U, Gruh I. Higher Frequencies of Bcrp+ Cardiac Resident Cells in Ischaemic Human Myocardium. Eur Heart J. 2013;34(36):2830-8.

Dahlmann J, Krause A, Moller L, Kensah G, Mowes M, Diekmann A, Martin U, Kirschning A, Gruh I, Drager G. Fully Defined in Situ Cross-Linkable Alginate and Hyaluronic Acid Hydrogels for Myocardial Tissue Engineering. Biomaterials. 2013;34(4):940-51.

Dahlmann J, Kensah G, Kempf H, Skvorc D, Gawol A, Elliott DA, Drager G, Zweigerdt R, Martin U, Gruh I. The Use of Agarose Microwells for Scalable Embryoid Body Formation and Cardiac Differentiation of Human and Murine Pluripotent Stem Cells. Biomaterials. 2013;34(10):2463-71.

2011

Moller L, Krause A, Dahlmann J, Gruh I, Kirschning A, Drager G. Preparation and Evaluation of Hydrogel-Composites from Methacrylated Hyaluronic Acid, Alginate, and Gelatin for Tissue Engineering. Int J Artif Organs. 2011;34(2):93-102.

Martens A, Gruh I, Dimitroulis D, Rojas SV, Schmidt-Richter I, Rathert C, Khaladj N, Gawol A, Chikobava MG, Martin U, Haverich A, Kutschka I. Rhesus Monkey Cardiosphere-Derived Cells for Myocardial Restoration. Cytotherapy. 2011;13(7):864-72.

Kuetemeyer K, Kensah G, Heidrich M, Meyer H, Martin U, Gruh I, Heisterkamp A. Two-Photon Induced Collagen Cross-Linking in Bioartificial Cardiac Tissue. Opt Express. 2011;19(17):15996-6007.

Kensah G, Gruh I, Viering J, Schumann H, Dahlmann J, Meyer H, Skvorc D, Bar A, Akhyari P, Heisterkamp A, Haverich A, Martin U. A Novel Miniaturized Multimodal Bioreactor for Continuous in Situ Assessment of Bioartificial Cardiac Tissue During Stimulation and Maturation. Tissue Eng Part C Methods. 2011;17(4):463-73.

2009

Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR, Martin U. Generation of Induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell. 2009;5(4):434-41.

Gruh I, Martin U. Transdifferentiation of Stem Cells: A Critical View. Adv Biochem Eng Biotechnol. 2009;114:73-106.

Gruh, U. Martin. Transdifferentiation of Stem Cells: A Critical View. Engineering of Stem Cells, U. Martin (editor), Springer-Verlag, 2009, ISBN 978-3-540-88805-5.

2008

Wunderlich S, Gruh I, Winkler ME, Beier J, Radtke K, Schmiedl A, Groos S, Haverich A, Martin U. Type Ii Pneumocyte-Restricted Green Fluorescent Protein Expression after Lentiviral Transduction of Lung Epithelial Cells. Hum Gene Ther. 2008;19(1):39-52.

Winkler ME, Mauritz C, Groos S, Kispert A, Menke S, Hoffmann A, Gruh I, Schwanke K, Haverich A, Martin U. Serum-Free Differentiation of Murine Embryonic Stem Cells into Alveolar Type Ii Epithelial Cells. Cloning Stem Cells. 2008;10(1):49-64.

Gruh I, Wunderlich S, Winkler M, Schwanke K, Heinke J, Blomer U, Ruhparwar A, Rohde B, Li RK, Haverich A, Martin U. Human Cmv Immediate-Early Enhancer: A Useful Tool to Enhance Cell-Type-Specific Expression from Lentiviral Vectors. J Gene Med. 2008;10(1):21-32.

2007

Ruhparwar A, Er F, Martin U, Radke K, Gruh I, Niehaus M, Karck M, Haverich A, Hoppe UC. Enrichment of Cardiac Pacemaker-Like Cells: Neuregulin-1 and Cyclic Amp Increase I(F)-Current Density and Connexin 40 Mrna Levels in Fetal Cardiomyocytes. Med Biol Eng Comput. 2007;45(2):221-7.

2006

Gruh I, Beilner J, Blomer U, Schmiedl A, Schmidt-Richter I, Kruse ML, Haverich A, Martin U. No Evidence of Transdifferentiation of Human Endothelial Progenitor Cells into Cardiomyocytes after Coculture with Neonatal Rat Cardiomyocytes. Circulation. 2006;113(10):1326-34.

2005

Gruh I, Schwanke K, Wunderlich S, Blomer U, Scherr M, Ganser A, Haverich A, Martin U. Shuttle System Allowing Simplified Cloning of Expression Cassettes into Advanced Generation Lentiviral Vectors. Biotechniques. 2005;38(4):530, 2, 4.

Unit 5.8 - Large Animal Models for Myocardial Repair

2017

Rojas SV, Meier M, Zweigerdt R, Eckardt D, Rathert C, Schecker N, Schmitto JD, Rojas-Hernandez S, Martin U, Kutschka I, Haverich A, Martens A. Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure. Artificial organs. 2017;41(2):192-9.

2016

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Hoffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016;49(4):1228-38.

Tudorache I, Horke A, Cebotari S, Sarikouch S, Boethig D, Breymann T, Beerbaum P, Bertram H, Westhoff-Bleck M, Theodoridis K, Bobylev D, Cheptanaru E, Ciubotaru A, Haverich A. Decellularized aortic homografts for aortic valve and aorta ascendens replacement. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016;50(1):89-97.

Sarikouch S, Horke A, Tudorache I, Beerbaum P, Westhoff-Bleck M, Boethig D, Repin O, Maniuc L, Ciubotaru A, Haverich A, Cebotari S. Decellularized fresh homografts for pulmonary valve replacement: a decade of clinical experience. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016;50(2):281-90.

Martens A, Beckmann E, Kaufeld T, Umminger J, Fleissner F, Koigeldiyev N, Krueger H, Puntigam J, Haverich A, Shrestha M. Total aortic arch repair: risk factor analysis and follow-up in 199 patients. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016;50(5):940-8.

2015

Theodoridis K, Tudorache I, Calistru A, Cebotari S, Meyer T, Sarikouch S, Bara C, Brehm R, Haverich A, Hilfiker A. Successful matrix guided tissue regeneration of decellularized pulmonary heart valve allografts in elderly sheep. Biomaterials. 2015;52:221-8.

Iablonskii P, Cebotari S, Tudorache I, Granados M, Morticelli L, Goecke T, Klein N, Korossis S, Hilfiker A, Haverich A. Tissue-engineered mitral valve: morphology and biomechanics dagger. Interact Cardiovasc Thorac Surg. 2015;20(6):712-9; discussion 9.

Goecke T, Hilfiker A, Haverich A, Cebotari S. Investigation of inflammatory response of decellularized porcine aortic tissue in mice: can we rely on this experimental setting? European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2015;47(3):e90-1.

Roumieh M, Ius F, Tudorache I, Ismail I, Fleissner F, Haverich A, Cebotari S. Comparison between Biological and Mechanical Aortic Valve Prostheses in Middle-Aged Patients Matched through Propensity Score Analysis: Long-Term Results. Eur J Cardiothorac Surg. 2015;48(1):129-36.

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Hoffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized Aortic Allografts Versus Pulmonary Autografts for Aortic Valve Replacement in the Growing Sheep Model: Haemodynamic and Morphological Results at 20 Months after Implantation. Eur J Cardiothorac Surg. 2015.

Goecke T, Hilfiker A, Haverich A, Cebotari S. Investigation of Inflammatory Response of Decellularized Porcine Aortic Tissue in Mice: Can We Rely on This Experimental Setting? Eur J Cardiothorac Surg. 2015;47(3):e90-1.

Goecke T, Tudorache I, Hilfiker A, Haverich A, Cebotari S. [Prefabrication of Heart Valves]. Chirurg. 2015;86(3):251-3. Prafabrikation von Herzklappen.

Iablonskii P, Cebotari S, Tudorache I, Granados M, Morticelli L, Goecke T, Klein N, Korossis S, Hilfiker A, Haverich A. Tissue-Engineered Mitral Valve: Morphology and Biomechanics Dagger. Interact Cardiovasc Thorac Surg. 2015;20(6):712-9; discussion 9.

2014

Neumann A, Sarikouch S, Breymann T, Cebotari S, Boethig D, Horke A, Beerbaum P, Westhoff-Bleck M, Bertram H, Ono M, Tudorache I, Haverich A, Beutel G. Early Systemic Cellular Immune Response in Children and Young Adults Receiving Decellularized Fresh Allografts for Pulmonary Valve Replacement. Tissue Eng Part A. 2014;20(5-6):1003-11.

Vukadinovic-Nikolic Z, Andree B, Dorfman SE, Pflaum M, Horvath T, Lux M, Venturini L, Bar A, Kensah G, Lara AR, Tudorache I, Cebotari S, Hilfiker-Kleiner D, Haverich A, Hilfiker A. Generation of Bioartificial Heart Tissue by Combining a Three-Dimensional Gel-Based Cardiac Construct with Decellularized Small Intestinal Submucosa. Tissue Eng Part A. 2014;20(3-4):799-809.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Hernandez SR, Schwanke K, Zweigerdt R, Martin U, Saito S, Haverich A, Kutschka I. Macroscopic Fluorescence Imaging: A Novel Technique to Monitor Retention and Distribution of Injected Microspheres in an Experimental Model of Ischemic Heart Failure. PLoS One. 2014;9(8):e101775.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Zweigerdt R, Schwanke K, Rojas-Hernandez S, Martin U, Saito S, Schmitto JD, Haverich A, Kutschka I. Substantial Early Loss of Induced Pluripotent Stem Cells Following Transplantation in Myocardial Infarction. Artif Organs. 2014;38(11):978-84.

2013

Neumann A, Cebotari S, Tudorache I, Haverich A, Sarikouch S. Heart Valve Engineering: Decellularized Allograft Matrices in Clinical Practice. Biomed Tech (Berl). 2013;58(5):453-6.

Emmert MY, Emmert LS, Martens A, Ismail I, Schmidt-Richter I, Gawol A, Seifert B, Haverich A, Martin U, Gruh I. Higher Frequencies of Bcrp+ Cardiac Resident Cells in Ischaemic Human Myocardium. Eur Heart J. 2013;34(36):2830-8.

Schilling T, Brandes G, Tudorache I, Cebotari S, Hilfiker A, Meyer T, Biskup C, Bauer M, Waldmann KH, Bach FW, Haverich A, Hassel T. In Vivo Degradation of Magnesium Alloy La63 Scaffolds for Temporary Stabilization of Biological Myocardial Grafts in a Swine Model. Biomed Tech (Berl). 2013;58(5):407-16.

Tudorache I, Calistru A, Baraki H, Meyer T, Hoffler K, Sarikouch S, Bara C, Gorler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic Replacement of Aortic Heart Valves with Tissue-Engineered Grafts. Tissue Eng Part A. 2013;19(15-16):1686-94.

2011

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I. Induced Pluripotent Stem Cell (Ipsc)-Derived Flk-1 Progenitor Cells Engraft, Differentiate, and Improve Heart Function in a Mouse Model of Acute Myocardial Infarction. Eur Heart J. 2011;32(21):2634-41.

Cebotari S, Tudorache I, Ciubotaru A, Boethig D, Sarikouch S, Goerler A, Lichtenberg A, Cheptanaru E, Barnaciuc S, Cazacu A, Maliga O, Repin O, Maniuc L, Breymann T, Haverich A. Use of Fresh Decellularized Allografts for Pulmonary Valve Replacement May Reduce the Reoperation Rate in Children and Young Adults: Early Report. Circulation. 2011;124(11 Suppl):S115-23.

2009

Tudorache I, Kostin S, Meyer T, Teebken O, Bara C, Hilfiker A, Haverich A, Cebotari S. Viable Vascularized Autologous Patch for Transmural Myocardial Reconstruction. Eur J Cardiothorac Surg. 2009;36(2):306-11; discussion 11.

Unit 5.9 - Regenerative Agents

2012

Limbourg FP. A quick fix?: Short-term CXC-chemokine receptor 4 inhibition redistributes proangiogenic bone marrow cells to ischemic myocardium in an endothelial nitric oxide synthasedependent fashion. Circulation. 2013;127(1):13–5. Epub 2012/12/04.

Napp LC, Augustynik M, Paesler F, Krishnasamy K, Woiterski J, Limbourg A, Bauersachs J, Drexler H, Le Noble F, Limbourg FP. Extrinsic Notch ligand Delta-like 1 regulates tip cell selection and vascular branching morphogenesis. Circ Res. 2012;110(4):530-5. Epub 2012/01/28.

2011

Kiyan Y, Limbourg A, Kiyan R, Tkachuk S, Limbourg FP, Ovsianikov A, Chichkov BN, Haller H, Dumler I. Urokinase receptor associates with myocardin to control vascular smooth muscle cells phenotype in vascular disease. Arterioscler Thromb Vasc Biol. 2012;32(1):110-22. Epub 2011/11/15.

Napp LC, Limbourg FP. Notch signalling in development,
maturation and maintenance of the arterial system. In: Deindl
B, Schaper W, eds. Arteriogenesis; 2011. Shaper Verlag, ISBN
978–3-8322–9797-8.

2010

Leifheit-Nestler M, Conrad G, Heida NM, Limbourg A, Limbourg FP, Seidler T, Schroeter MR, Hasenfuss G, Konstantinides S, Schafer K. Overexpression of integrin beta 5 enhances the paracrine properties of circulating angiogenic cells via Src kinase-mediated activation of STAT3. Arterioscler Thromb Vasc Biol. 2010;30(7):1398-406. Epub 2010/05/01.

2009

Heida NM, Leifheit-Nestler M, Schroeter MR, Muller JP, Cheng IF, Henkel S, Limbourg A, Limbourg FP, Alves F, Quigley JP, Ruggeri ZM, Hasenfuss G, Konstantinides S, Schafer K. Leptin enhances the potency of circulating angiogenic cells via src kinase and integrin (alpha)vbeta5: implications for angiogenesis in human obesity. Arterioscler Thromb Vasc Biol. 2010;30(2):200-6. Epub 2009/11/17.

Limbourg A, Korff T, Napp LC, Schaper W, Drexler H, Limbourg FP. Evaluation of postnatal arteriogenesis and angiogenesis in a mouse model of hind-limb ischemia. Nat Protoc. 2009;4(12):1737-46. Epub 2009/11/07.

Limbourg FP, Drexler H. Quo vadis, progenitor? Progenitor cell homing in chronic ischemic heart disease. J Cardiovasc Pharmacol. 2009;53(6):438-9. Epub 2009/05/13.

2008

Templin C, Kotlarz D, Faulhaber J, Schnabel S, Grote K, Salguero G, Luchtefeld M, Hiller KH, Jakob P, Naim HY, Schieffer B, Hilfiker-Kleiner D, Landmesser U, Limbourg FP, Drexler H. Ex vivo expanded hematopoietic progenitor cells improve cardiac function after myocardial infarction: role of beta-catenin transduction and cell dose. J Mol Cell Cardiol. 2008;45(3):394-403. Epub 2008/08/02.

2007

Tongers J, Knapp JM, Korf M, Kempf T, Limbourg A, Limbourg FP, Li Z, Fraccarollo D, Bauersachs J, Han X, Drexler H, Fiedler B, Wollert KC. Haeme oxygenase promotes progenitor cell mobilization, neovascularization, and functional recovery after critical hindlimb ischaemia in mice. Cardiovasc Res. 2008;78(2):294-300. Epub 2007/12/21.

Limbourg A, Ploom M, Elligsen D, Sorensen I, Ziegelhoeffer T, Gossler A, Drexler H, Limbourg FP. Notch ligand Delta-like 1 is essential for postnatal arteriogenesis. Circ Res. 2007;100(3):363-71. Epub 2007/01/20.

2005

Limbourg FP, Takeshita K, Radtke F, Bronson RT, Chin MT, Liao JK. Essential role of endothelial Notch1 in angiogenesis. Circulation. 2005;111(14):1826-32. Epub 2005/04/06.

Unit 6.1 - Enhanced and Synthetic Cells for Regeneration

2016

Stahlhut M, Schambach A, Kustikova OS. Transduction of Murine Hematopoietic Stem Cells with Tetracycline-regulated Lentiviral Vectors. Methods in molecular biology. 2016;1448:65-76.

Stahlhut M, Ha TC, Morgan M, Schambach A, Kustikova OS. Comparison of tetracycline-regulated promoters in lentiviral-based vectors in murine transplantation studies. Curr Gene Ther. 2016.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell stem cell. 2016;18(6):797-808.

Skuljec J, Cabanski M, Surdziel E, Lachmann N, Brennig S, Pul R, Jirmo AC, Habener A, Visic J, Daluge K, Hennig C, Moritz T, Happle C, Hansen G. Monocyte/macrophage lineage commitment and distribution are affected by the lack of regulatory T cells in scurfy mice. Eur J Immunol. 2016;46(7):1656-68.

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M. Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology. Stem cells translational medicine. 2016;5(5):591-601.

Schott JW, Morgan M, Galla M, Schambach A. Viral and Synthetic RNA Vector Technologies and Applications. Molecular therapy : the journal of the American Society of Gene Therapy. 2016;24(9):1513-27.

Papapetrou EP, Schambach A. Gene Insertion Into Genomic Safe Harbors for Human Gene Therapy. Molecular therapy : the journal of the American Society of Gene Therapy. 2016;24(4):678-84.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kuhnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem cell reports. 2016;7(2):292-305.

Manukjan G, Ripperger T, Venturini L, Stadler M, Gohring G, Schambach A, Schlegelberger B, Steinemann D. GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. Stem cell research. 2016;16(3):677-81.

Maetzig T, Schambach A. Development of Inducible Molecular Switches Based on All-in-One Lentiviral Vectors Equipped with Drug Controlled FLP Recombinase. Methods in molecular biology. 2016;1448:23-39.

Karpinski J, Hauber I, Chemnitz J, Schafer C, Paszkowski-Rogacz M, Chakraborty D, Beschorner N, Hofmann-Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi-Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F. Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nat Biotechnol. 2016;34(4):401-9.

Eggenschwiler R, Moslem M, Fraguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wahner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Scientific reports. 2016;6:38198.

Borger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C. Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions. Molecular medicine. 2016;22.

2015

Stahlhut M, Schwarzer A, Eder M, Yang M, Li Z, Morgan M, Schambach A, Kustikova OS. Lentiviral vector system for coordinated constitutive and drug controlled tetracycline-regulated gene co-expression. Biomaterials. 2015;63:189-201.

Lachmann N, Brennig S, Hillje R, Schermeier H, Phaltane R, Dahlmann J, Gruh I, Heinz N, Schiedlmeier B, Baum C, Moritz T. Tightly regulated 'all-in-one' lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy. Gene therapy. 2015;22(11):883-92.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T. TALEN-mediated functional correction of X-linked chronic granulomatous disease in patient-derived induced pluripotent stem cells. Biomaterials. 2015;69:191-200.

Brennig S, Lachmann N, Buchegger T, Hetzel M, Schambach A, Moritz T. “Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1)”. Journal of Experimental & Clinical Cancer Research. 2015.

Suerth JD, Morgan MA, Kloess S, Heckl D, Neudorfl C, Falk CS, Koehl U, Schambach A. Efficient Generation of Gene-Modified Human Natural Killer Cells Via Alpharetroviral Vectors. J Mol Med (Berl). 2015.

Stahlhut M, Schwarzer A, Eder M, Yang M, Li Z, Morgan M, Schambach A, Kustikova OS. Lentiviral Vector System for Coordinated Constitutive and Drug Controlled Tetracycline-Regulated Gene Co-Expression. Biomaterials. 2015;63:189-201.

Schwarzer A, Holtmann H, Brugman M, Meyer J, Schauerte C, Zuber J, Steinemann D, Schlegelberger B, Li Z, Baum C. Hyperactivation of Mtorc1 and Mtorc2 by Multiple Oncogenic Events Causes Addiction to Eif4e-Dependent Mrna Translation in T-Cell Leukemia. Oncogene. 2015;34(27):3593-604.

Schott JW, Jaeschke NM, Hoffmann D, Maetzig T, Ballmaier M, Godinho T, Cathomen T, Schambach A. Deciphering the Impact of Parameters Influencing Transgene Expression Kinetics after Repeated Cell Transduction with Integration-Deficient Retroviral Vectors. Cytometry A. 2015;87(5):405-18.

Rissone A, Weinacht KG, la Marca G, Bishop K, Giocaliere E, Jagadeesh J, Felgentreff K, Dobbs K, Al-Herz W, Jones M, Chandrasekharappa S, Kirby M, Wincovitch S, Simon KL, Itan Y, DeVine A, Schlaeger T, Schambach A, Sood R, Notarangelo LD, Candotti F. Reticular Dysgenesis-Associated Ak2 Protects Hematopoietic Stem and Progenitor Cell Development from Oxidative Stress. J Exp Med. 2015;212(8):1185-202.

Ripperger T, Manukjan G, Meyer J, Wolter S, Schambach A, Bohne J, Modlich U, Li Z, Skawran B, Schlegelberger B, Steinemann D. The Heteromeric Transcription Factor Gabp Activates the Itgam/Cd11b Promoter and Induces Myeloid Differentiation. Biochim Biophys Acta. 2015;1849(9):1145-54.

Regelin M, Blume J, Pommerencke J, Vakilzadeh R, Witzlau K, Lyszkiewicz M, Zietara N, Saran N, Schambach A, Krueger A. Responsiveness of Developing T Cells to Il-7 Signals Is Sustained by Mir-17 Approximately 92. J Immunol. 2015;195(10):4832-40. Epub 2015/10/18.

Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T. Rescue of DNA-Pk Signaling and T-Cell Differentiation by Targeted Genome Editing in a Prkdc Deficient Ipsc Disease Model. PLoS Genet. 2015;11(5):e1005239.

Muller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M. A Minimal Ubiquitous Chromatin Opening Element (Ucoe) Effectively Prevents Silencing of Juxtaposed Heterologous Promoters by Epigenetic Remodeling in Multipotent and Pluripotent Stem Cells. Nucleic Acids Res. 2015;43(3):1577-92.

Manukjan G, Ripperger T, Santer L, von Neuhoff N, Ganser A, Schambach A, Schlegelberger B, Steinemann D. Expression of the Ets Transcription Factor Gabpalpha Is Positively Correlated to the Bcr-Abl1/Abl1 Ratio in Cml Patients and Affects Imatinib Sensitivity in Vitro. Exp Hematol. 2015;43(10):880-90. Epub 2015/06/15.

Lyszkiewicz M, Zietara N, Fohse L, Puchalka J, Diestelhorst J, Witzlau K, Prinz I, Schambach A, Krueger A. Limited Niche Availability Suppresses Murine Intrathymic Dendritic-Cell Development from Noncommitted Progenitors. Blood. 2015;125(3):457-64.

Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T. Deoxycytidine-Kinase Knockdown as a Novel Myeloprotective Strategy in the Context of Fludarabine, Cytarabine or Cladribine Therapy. Leukemia. 2015;29(11):2266-9. Epub 2015/04/30.

Lachmann N, Brennig S, Hillje R, Schermeier H, Phaltane R, Dahlmann J, Gruh I, Heinz N, Schiedlmeier B, Baum C, Moritz T. Tightly Regulated 'All-in-One' Lentiviral Vectors for Protection of Human Hematopoietic Cells from Anticancer Chemotherapy. Gene Ther. 2015;22(11):883-92.

Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Luttge D, Buchegger T, Kuhnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T. Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies. Stem Cell Reports. 2015;4(2):282-96.

Hoseini SS, Hapke M, Herbst J, Wedekind D, Baumann R, Heinz N, Schiedlmeier B, Vignali DA, van den Brink MR, Schambach A, Blazar BR, Sauer MG. Inducible T-Cell Receptor Expression in Precursor T Cells for Leukemia Control. Leukemia. 2015;29(7):1530-42.

Hoffmann D, Gohring G, Heuser M, Ganser A, Schambach A, Morgan MA. Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an Aml Diagnostic Sample Containing the T(8;21) Translocation. Stem Cells. 2015.

Heinz N, Ehrnstrom B, Schambach A, Schwarzer A, Modlich U, Schiedlmeier B. Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells. Stem Cells Transl Med. 2015;4(9):1064-72. Epub 2015/07/15.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T. Talen-Mediated Functional Correction of X-Linked Chronic Granulomatous Disease in Patient-Derived Induced Pluripotent Stem Cells. Biomaterials. 2015;69:191-200.

Dobbs K, Dominguez Conde C, Zhang SY, Parolini S, Audry M, Chou J, Haapaniemi E, Keles S, Bilic I, Okada S, Massaad MJ, Rounioja S, Alwahadneh AM, Serwas NK, Capuder K, Ciftci E, Felgentreff K, Ohsumi TK, Pedergnana V, Boisson B, Haskologlu S, Ensari A, Schuster M, Moretta A, Itan Y, Patrizi O, Rozenberg F, Lebon P, Saarela J, Knip M, Petrovski S, Goldstein DB, Parrott RE, Savas B, Schambach A, Tabellini G, Bock C, Chatila TA, Comeau AM, Geha RS, Abel L, Buckley RH, Ikinciogullari A, Al-Herz W, Helminen M, Dogu F, Casanova JL, Boztug K, Notarangelo LD. Inherited Dock2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med. 2015;372(25):2409-22.

Ackermann M, Liebhaber S, Klusmann JH, Lachmann N. Lost in Translation: Pluripotent Stem Cell-Derived Hematopoiesis. EMBO Mol Med. 2015;7(11):1388-402.

2014

Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Maetzig T, Goodman SB, Stiehler M. Enhancement of Bmp-2 Induced Bone Regeneration by Sdf-1alpha Mediated Stem Cell Recruitment. Tissue Eng Part A. 2014;20(3-4):810-8.

Zhang H, Goudeva L, Immenschuh S, Schambach A, Skokowa J, Eiz-Vesper B, Blasczyk R, Figueiredo C. Mir-155 Is Associated with the Leukemogenic Potential of the Class Iv Granulocyte Colony-Stimulating Factor Receptor in Cd34(+) Progenitor Cells. Mol Med. 2014;20:736-46. Epub 2015/03/03.

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9.

Thomay K, Schienke A, Vajen B, Modlich U, Schambach A, Hofmann W, Schlegelberger B, Gohring G. Chromosomal Instability and Telomere Shortening in Long-Term Culture of Hematopoietic Stem Cells: Insights from a Cell Culture Model of Rps14 Haploinsufficiency. Cytogenet Genome Res. 2014;142(1):14-20.

Suzuki T, Arumugam P, Sakagami T, Lachmann N, Chalk C, Sallese A, Abe S, Trapnell C, Carey B, Moritz T, Malik P, Lutzko C, Wood RE, Trapnell BC. Pulmonary Macrophage Transplantation Therapy. Nature. 2014;514(7523):450-4.

Suerth JD, Labenski V, Schambach A. Alpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapy. Viruses. 2014;6(12):4811-38.

Rothe M, Schambach A, Biasco L. Safety of Gene Therapy: New Insights to a Puzzling Case. Curr Gene Ther. 2014;14(6):429-36.

Phaltane R, Lachmann N, Brennig S, Ackermann M, Modlich U, Moritz T. Lentiviral Mgmt(P140k)-Mediated in Vivo Selection Employing a Ubiquitous Chromatin Opening Element (A2ucoe) Linked to a Cellular Promoter. Biomaterials. 2014;35(25):7204-13. Epub 2014/05/31.

Maetzig T, Kuehle J, Schwarzer A, Turan S, Rothe M, Chaturvedi A, Morgan M, Ha TC, Heuser M, Hammerschmidt W, Baum C, Schambach A. All-in-One Inducible Lentiviral Vector Systems Based on Drug Controlled Flp Recombinase. Biomaterials. 2014;35(14):4345-56.

Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming. Cell Stem Cell. 2014;15(5):574-88.

Limbourg A, Schnabel S, Lozanovski VJ, Napp LC, Ha TC, Maetzig T, Bauersachs J, Naim HY, Schambach A, Limbourg FP. Genetic Reporter Analysis Reveals an Expandable Reservoir of Oct4+ Cells in Adult Skin. Cell Regen (Lond). 2014;3(1):9.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Kustikova OS, Stahlhut M, Ha TC, Scherer R, Schambach A, Baum C. Dose Response and Clonal Variability of Lentiviral Tetracycline-Regulated Vectors in Murine Hematopoietic Cells. Exp Hematol. 2014;42(7):505-15 e7.

Kuehle J, Turan S, Cantz T, Hoffmann D, Suerth JD, Maetzig T, Zychlinski D, Klein C, Steinemann D, Baum C, Bode J, Schambach A. Modified Lentiviral Ltrs Allow Flp Recombinase-Mediated Cassette Exchange and in Vivo Tracing of "Factor-Free" Induced Pluripotent Stem Cells. Mol Ther. 2014;22(5):919-28.

Happle C, Lachmann N, Skuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. Pulmonary Transplantation of Macrophage Progenitors as Effective and Long-Lasting Therapy for Hereditary Pulmonary Alveolar Proteinosis. Sci Transl Med. 2014;6(250):250ra113.

Haemmerle R, Phaltane R, Rothe M, Schroder S, Schambach A, Moritz T, Modlich U. Clonal Dominance with Retroviral Vector Insertions near the Angpt1 and Angpt2 Genes in a Human Xenotransplant Mouse Model. Mol Ther Nucleic Acids. 2014;3:e200.

Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernandez KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot F, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD, Fischer A, Kohn DB, Filipovich AH, Notarangelo LD, Cavazzana M, Williams DA, Thrasher AJ. A Modified Gamma-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency. N Engl J Med. 2014;371(15):1407-17.

Braun CJ, Boztug K, Paruzynski A, Witzel M, Schwarzer A, Rothe M, Modlich U, Beier R, Gohring G, Steinemann D, Fronza R, Ball CR, Haemmerle R, Naundorf S, Kuhlcke K, Rose M, Fraser C, Mathias L, Ferrari R, Abboud MR, Al-Herz W, Kondratenko I, Marodi L, Glimm H, Schlegelberger B, Schambach A, Albert MH, Schmidt M, von Kalle C, Klein C. Gene Therapy for Wiskott-Aldrich Syndrome--Long-Term Efficacy and Genotoxicity. Sci Transl Med. 2014;6(227):227ra33.

Bobis-Wozowicz S, Galla M, Alzubi J, Kuehle J, Baum C, Schambach A, Cathomen T. Non-Integrating Gamma-Retroviral Vectors as a Versatile Tool for Transient Zinc-Finger Nuclease Delivery. Sci Rep. 2014;4:4656.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

2013

Zwingenberger S, Yao Z, Jacobi A, Vater C, Valladares RD, Li C, Nich C, Rao AJ, Christman JE, Antonios JK, Gibon E, Schambach A, Matzig T, Gunther KP, Goodman SB, Stiehler M. Stem Cell Attraction Via Sdf-1alpha Expressing Fat Tissue Grafts. J Biomed Mater Res A. 2013;101(7):2067-74.

Wolf S, Rudolph C, Morgan M, Busche G, Salguero G, Stripecke R, Schlegelberger B, Baum C, Modlich U. Selection for Evi1 Activation in Myelomonocytic Leukemia Induced by Hyperactive Signaling through Wild-Type Nras. Oncogene. 2013;32(25):3028-38.

Sundarasetty BS, Singh VK, Salguero G, Geffers R, Rickmann M, Macke L, Borchers S, Figueiredo C, Schambach A, Gullberg U, Provasi E, Bonini C, Ganser A, Woelfel T, Stripecke R. Lentivirus-Induced Dendritic Cells for Immunization against High-Risk Wt1(+) Acute Myeloid Leukemia. Hum Gene Ther. 2013;24(2):220-37.

Stein S, Scholz S, Schwable J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Muller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG, Jr., Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kuhlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M. From Bench to Bedside: Preclinical Evaluation of a Self-Inactivating Gammaretroviral Vector for the Gene Therapy of X-Linked Chronic Granulomatous Disease. Hum Gene Ther Clin Dev. 2013;24(2):86-98.

Schambach A, Zychlinski D, Ehrnstroem B, Baum C. Biosafety Features of Lentiviral Vectors. Hum Gene Ther. 2013;24(2):132-42.

Schambach A, Moritz T. Toward Position-Independent Retroviral Vector Expression in Pluripotent Stem Cells. Mol Ther. 2013;21(8):1474-7.

Rothe M, Modlich U, Schambach A. Biosafety Challenges for Use of Lentiviral Vectors in Gene Therapy. Curr Gene Ther. 2013;13(6):453-68.

Rittelmeyer I, Rothe M, Brugman MH, Iken M, Schambach A, Manns MP, Baum C, Modlich U, Ott M. Hepatic Lentiviral Gene Transfer Is Associated with Clonal Selection, but Not with Tumor Formation in Serially Transplanted Rodents. Hepatology. 2013;58(1):397-408.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. A Ubiquitous Chromatin Opening Element Prevents Transgene Silencing in Pluripotent Stem Cells and Their Differentiated Progeny. Stem Cells. 2013;31(3):488-99.

Mandel K, Yang Y, Schambach A, Glage S, Otte A, Hass R. Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth in Vitro and in Vivo. Stem Cells Dev. 2013;22(23):3114-27.

Lachmann N, Brennig S, Pfaff N, Schermeier H, Dahlmann J, Phaltane R, Gruh I, Modlich U, Schambach A, Baum C, Moritz T. Efficient in Vivo Regulation of Cytidine Deaminase Expression in the Haematopoietic System Using a Doxycycline-Inducible Lentiviral Vector System. Gene Ther. 2013;20(3):298-307.

Kustikova OS, Schwarzer A, Stahlhut M, Brugman MH, Neumann T, Yang M, Li Z, Schambach A, Heinz N, Gerdes S, Roeder I, Ha TC, Steinemann D, Schlegelberger B, Baum C. Activation of Evi1 Inhibits Cell Cycle Progression and Differentiation of Hematopoietic Progenitor Cells. Leukemia. 2013;27(5):1127-38.

Kaufmann KB, Buning H, Galy A, Schambach A, Grez M. Gene Therapy on the Move. EMBO Mol Med. 2013;5(11):1642-61.

Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwable J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M. Alpharetroviral Vector-Mediated Gene Therapy for X-Cgd: Functional Correction and Lack of Aberrant Splicing. Mol Ther. 2013;21(3):648-61.

Hauber I, Hofmann-Sieber H, Chemnitz J, Dubrau D, Chusainow J, Stucka R, Hartjen P, Schambach A, Ziegler P, Hackmann K, Schrock E, Schumacher U, Lindner C, Grundhoff A, Baum C, Manz MG, Buchholz F, Hauber J. Highly Significant Antiviral Activity of Hiv-1 Ltr-Specific Tre-Recombinase in Humanized Mice. PLoS Pathog. 2013;9(9):e1003587.

Gurlevik E, Fleischmann-Mundt B, Armbrecht N, Longerich T, Woller N, Kloos A, Hoffmann D, Schambach A, Wirth TC, Manns MP, Zender L, Kubicka S, Kuhnel F. Adjuvant Gemcitabine Therapy Improves Survival in a Locally Induced, R0-Resectable Model of Metastatic Intrahepatic Cholangiocarcinoma. Hepatology. 2013;58(3):1031-41.

Gupta SS, Maetzig T, Maertens GN, Sharif A, Rothe M, Weidner-Glunde M, Galla M, Schambach A, Cherepanov P, Schulz TF. Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration. J Virol. 2013;87(23):12721-36.

Gross B, Sgodda M, Rasche M, Schambach A, Gohring G, Schlegelberger B, Greber B, Linden T, Reinhardt D, Cantz T, Klusmann JH. Improved Generation of Patient-Specific Induced Pluripotent Stem Cells Using a Chemically-Defined and Matrigel-Based Approach. Curr Mol Med. 2013;13(5):765-76.

Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemann D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvak Z, Sarkadi B, Ivics Z. Sleeping Beauty Transposon-Based System for Cellular Reprogramming and Targeted Gene Insertion in Induced Pluripotent Stem Cells. Nucleic Acids Res. 2013;41(3):1829-47.

Galla M, Schambach A, Baum C. Retrovirus-Based Mrna Transfer for Transient Cell Manipulation. Methods Mol Biol. 2013;969:139-61.

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med. 2013;2(9):641-54.

Brugman MH, Suerth JD, Rothe M, Suerbaum S, Schambach A, Modlich U, Kustikova O, Baum C. Evaluating a Ligation-Mediated Pcr and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples. Hum Gene Ther Methods. 2013;24(2):68-79.

2012

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84.

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL. A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage. Cell. 2012;148(5):1001-14.

Suerth JD, Schambach A, Baum C. Genetic Modification of Lymphocytes by Retrovirus-Based Vectors. Curr Opin Immunol. 2012;24(5):598-608.

 

Suerth JD, Maetzig T, Brugman MH, Heinz N, Appelt JU, Kaufmann KB, Schmidt M, Grez M, Modlich U, Baum C, Schambach A. Alpharetroviral Self-Inactivating Vectors: Long-Term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity. Mol Ther. 2012;20(5):1022-32.

Schambach A, Baum C. Vectorizing Mrna and Proteins. Curr Gene Ther. 2012;12(5):345-6.

Maetzig T, Baum C, Schambach A. Retroviral Protein Transfer: Falling Apart to Make an Impact. Curr Gene Ther. 2012;12(5):389-409.

Lesinski DA, Heinz N, Pilat-Carotta S, Rudolph C, Jacobs R, Schlegelberger B, Klump H, Schiedlmeier B. Serum- and Stromal Cell-Free Hypoxic Generation of Embryonic Stem Cell-Derived Hematopoietic Cells in Vitro, Capable of Multilineage Repopulation of Immunocompetent Mice. Stem Cells Transl Med. 2012;1(8):581-91.

Koch L, Deiwick A, Schlie S, Michael S, Gruene M, Coger V, Zychlinski D, Schambach A, Reimers K, Vogt PM, Chichkov B. Skin Tissue Generation by Laser Cell Printing. Biotechnol Bioeng. 2012;109(7):1855-63.

Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernandez JA, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M. Pharmacological Targeting of the Thrombomodulin-Activated Protein C Pathway Mitigates Radiation Toxicity. Nat Med. 2012;18(7):1123-9.

Blank U, Ehrnstrom B, Heinz N, Nilsson E, Brun A, Baum C, Schiedlmeier B, Karlsson S. Angptl4 Maintains in Vivo Repopulation Capacity of Cd34+ Human Cord Blood Cells. Eur J Haematol. 2012;89(3):198-205.

Abdollahpour H, Appaswamy G, Kotlarz D, Diestelhorst J, Beier R, Schaffer AA, Gertz EM, Schambach A, Kreipe HH, Pfeifer D, Engelhardt KR, Rezaei N, Grimbacher B, Lohrmann S, Sherkat R, Klein C. The Phenotype of Human Stk4 Deficiency. Blood. 2012;119(15):3450-7.

Unit 6.2 - Regenerative Gene Therapy

2017

>Punwani D, Kawahara M, Yu J, Sanford U, Roy S, Patel K, Carbonaro DA, Karlen AD, Khan S, Cornetta K, Rothe M, Schambach A, Kohn DB, Malech HL, McIvor RS, Puck JM, Cowan MJ. Lentivirus Mediated Correction of Artemis-Deficient Severe Combined Immunodeficiency. Hum Gene Ther. 2017;28(1):112-24.

2016

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T. Long noncoding RNA Chast promotes cardiac remodeling. Science translational medicine. 2016;8(326):326ra22.

Thiesler CT, Cajic S, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weibetamann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Korner C, Schambach A, Rapp E, Buettner FF. Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG). Molecular & cellular proteomics : MCP. 2016;15(4):1435-52.

Stahlhut M, Schambach A, Kustikova OS. Transduction of Murine Hematopoietic Stem Cells with Tetracycline-regulated Lentiviral Vectors. Methods in molecular biology. 2016;1448:65-76.

Stahlhut M, Ha TC, Morgan M, Schambach A, Kustikova OS. Comparison of tetracycline-regulated promoters in lentiviral-based vectors in murine transplantation studies. Curr Gene Ther. 2016.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell stem cell. 2016;18(6):797-808.

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M. Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology. Stem cells translational medicine. 2016;5(5):591-601.

Schott JW, Morgan M, Galla M, Schambach A. Viral and Synthetic RNA Vector Technologies and Applications. Molecular therapy : the journal of the American Society of Gene Therapy. 2016;24(9):1513-27.

Schambach A, Morgan M. Retroviral Vectors for Cancer Gene Therapy. Recent Results Cancer Res. 2016;209:17-35.

Salari A, Thomay K, Himmler K, Vajen B, Schienke A, Hagedorn M, Ebersold J, Kreipe HH, Kruger A, Schambach A, Schlegelberger B, Gohring G. Establishing a murine xenograft-model for long-term analysis of factors inducing chromosomal instability in myelodysplastic syndrome: Pitfalls and successes. Cancer Genet. 2016;209(6):258-66.

Papapetrou EP, Schambach A. Gene Insertion Into Genomic Safe Harbors for Human Gene Therapy. Molecular therapy : the journal of the American Society of Gene Therapy. 2016;24(4):678-84.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kuhnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem cell reports. 2016;7(2):292-305.

Manukjan G, Ripperger T, Venturini L, Stadler M, Gohring G, Schambach A, Schlegelberger B, Steinemann D. GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. Stem cell research. 2016;16(3):677-81.

Maetzig T, Schambach A. Development of Inducible Molecular Switches Based on All-in-One Lentiviral Vectors Equipped with Drug Controlled FLP Recombinase. Methods in molecular biology. 2016;1448:23-39.

Labenski V, Suerth JD, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams DA, Fehse B, Verhoeyen E, Schambach A. Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Biomaterials. 2016;97:97-109.

Karpinski J, Hauber I, Chemnitz J, Schafer C, Paszkowski-Rogacz M, Chakraborty D, Beschorner N, Hofmann-Sieber H, Lange UC, Grundhoff A, Hackmann K, Schrock E, Abi-Ghanem J, Pisabarro MT, Surendranath V, Schambach A, Lindner C, van Lunzen J, Hauber J, Buchholz F. Directed evolution of a recombinase that excises the provirus of most HIV-1 primary isolates with high specificity. Nat Biotechnol. 2016;34(4):401-9.

Hubner J, Hoseini SS, Suerth JD, Hoffmann D, Maluski M, Herbst J, Maul H, Ghosh A, Eiz-Vesper B, Yuan Q, Ott M, Heuser M, Schambach A, Sauer MG. Generation of Genetically Engineered Precursor T-Cells From Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform. Molecular therapy : the journal of the American Society of Gene Therapy. 2016;24(7):1216-26.

Huang J, Liu Y, Au BC, Barber DL, Arruda A, Schambach A, Rothe M, Minden MD, Paige CJ, Medin JA. Preclinical validation: LV/IL-12 transduction of patient leukemia cells for immunotherapy of AML. Mol Ther Methods Clin Dev. 2016;3:16074.

Garcia-Gomez M, Calabria A, Garcia-Bravo M, Benedicenti F, Kosinski P, Lopez-Manzaneda S, Hill C, Del Mar Manu-Pereira M, Martin MA, Orman I, Vives-Corrons JL, Kung C, Schambach A, Jin S, Bueren JA, Montini E, Navarro S, Segovia JC. Safe and Efficient Gene Therapy for Pyruvate Kinase Deficiency. Molecular therapy : the journal of the American Society of Gene Therapy. 2016;24(7):1187-98.

Eggenschwiler R, Moslem M, Fraguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wahner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Scientific reports. 2016;6:38198.

Brendel C, Guda S, Renella R, Bauer DE, Canver MC, Kim YJ, Heeney MM, Klatt D, Fogel J, Milsom MD, Orkin SH, Gregory RI, Williams DA. Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype. J Clin Invest. 2016;126(10):3868-78.

Borger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C. Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions. Molecular medicine. 2016;22.

Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Scientific reports. 2016;6:20007.

2015

Uhlig KM, Schulke S, Scheuplein VA, Malczyk AH, Reusch J, Kugelmann S, Muth A, Koch V, Hutzler S, Bodmer BS, Schambach A, Buchholz CJ, Waibler Z, Scheurer S, Muhlebach MD. Lentiviral Protein Transfer Vectors Are an Efficient Vaccine Platform and Induce a Strong Antigen-Specific Cytotoxic T Cell Response. J Virol. 2015;89(17):9044-60.

Suerth JD, Morgan MA, Kloess S, Heckl D, Neudorfl C, Falk CS, Koehl U, Schambach A. Efficient Generation of Gene-Modified Human Natural Killer Cells Via Alpharetroviral Vectors. J Mol Med (Berl). 2015. Epub 2015/08/25.

Stahlhut M, Schwarzer A, Eder M, Yang M, Li Z, Morgan M, Schambach A, Kustikova OS. Lentiviral Vector System for Coordinated Constitutive and Drug Controlled Tetracycline-Regulated Gene Co-Expression. Biomaterials. 2015;63:189-201.

Schwarzer A, Holtmann H, Brugman M, Meyer J, Schauerte C, Zuber J, Steinemann D, Schlegelberger B, Li Z, Baum C. Hyperactivation of Mtorc1 and Mtorc2 by Multiple Oncogenic Events Causes Addiction to Eif4e-Dependent Mrna Translation in T-Cell Leukemia. Oncogene. 2015;34(27):3593-604.

Schott JW, Jaeschke NM, Hoffmann D, Maetzig T, Ballmaier M, Godinho T, Cathomen T, Schambach A. Deciphering the Impact of Parameters Influencing Transgene Expression Kinetics after Repeated Cell Transduction with Integration-Deficient Retroviral Vectors. Cytometry A. 2015;87(5):405-18.

Schott JW, Hoffmann D, Schambach A. Retrovirus-Based Vectors for Transient and Permanent Cell Modification. Curr Opin Pharmacol. 2015;24:135-46.

Rissone A, Weinacht KG, la Marca G, Bishop K, Giocaliere E, Jagadeesh J, Felgentreff K, Dobbs K, Al-Herz W, Jones M, Chandrasekharappa S, Kirby M, Wincovitch S, Simon KL, Itan Y, DeVine A, Schlaeger T, Schambach A, Sood R, Notarangelo LD, Candotti F. Reticular Dysgenesis-Associated Ak2 Protects Hematopoietic Stem and Progenitor Cell Development from Oxidative Stress. J Exp Med. 2015;212(8):1185-202.

Ripperger T, Manukjan G, Meyer J, Wolter S, Schambach A, Bohne J, Modlich U, Li Z, Skawran B, Schlegelberger B, Steinemann D. The Heteromeric Transcription Factor Gabp Activates the Itgam/Cd11b Promoter and Induces Myeloid Differentiation. Biochim Biophys Acta. 2015;1849(9):1145-54.

Regelin M, Blume J, Pommerencke J, Vakilzadeh R, Witzlau K, Lyszkiewicz M, Zietara N, Saran N, Schambach A, Krueger A. Responsiveness of Developing T Cells to Il-7 Signals Is Sustained by Mir-17 Approximately 92. J Immunol. 2015;195(10):4832-40. Epub 2015/10/18.

Rahman SH, Kuehle J, Reimann C, Mlambo T, Alzubi J, Maeder ML, Riedel H, Fisch P, Cantz T, Rudolph C, Mussolino C, Joung JK, Schambach A, Cathomen T. Rescue of DNA-Pk Signaling and T-Cell Differentiation by Targeted Genome Editing in a Prkdc Deficient Ipsc Disease Model. PLoS Genet. 2015;11(5):e1005239.

Muller-Kuller U, Ackermann M, Kolodziej S, Brendel C, Fritsch J, Lachmann N, Kunkel H, Lausen J, Schambach A, Moritz T, Grez M. A Minimal Ubiquitous Chromatin Opening Element (Ucoe) Effectively Prevents Silencing of Juxtaposed Heterologous Promoters by Epigenetic Remodeling in Multipotent and Pluripotent Stem Cells. Nucleic Acids Res. 2015;43(3):1577-92.

Manukjan G, Ripperger T, Santer L, von Neuhoff N, Ganser A, Schambach A, Schlegelberger B, Steinemann D. Expression of the Ets Transcription Factor Gabpalpha Is Positively Correlated to the Bcr-Abl1/Abl1 Ratio in Cml Patients and Affects Imatinib Sensitivity in Vitro. Exp Hematol. 2015;43(10):880-90. Epub 2015/06/15.

Lyszkiewicz M, Zietara N, Fohse L, Puchalka J, Diestelhorst J, Witzlau K, Prinz I, Schambach A, Krueger A. Limited Niche Availability Suppresses Murine Intrathymic Dendritic-Cell Development from Noncommitted Progenitors. Blood. 2015;125(3):457-64.

Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T. Deoxycytidine-Kinase Knockdown as a Novel Myeloprotective Strategy in the Context of Fludarabine, Cytarabine or Cladribine Therapy. Leukemia. 2015;29(11):2266-9. Epub 2015/04/30.

Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Luttge D, Buchegger T, Kuhnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T. Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies. Stem Cell Reports. 2015;4(2):282-96.

Hoseini SS, Hapke M, Herbst J, Wedekind D, Baumann R, Heinz N, Schiedlmeier B, Vignali DA, van den Brink MR, Schambach A, Blazar BR, Sauer MG. Inducible T-Cell Receptor Expression in Precursor T Cells for Leukemia Control. Leukemia. 2015;29(7):1530-42.

Hoffmann D, Gohring G, Heuser M, Ganser A, Schambach A, Morgan MA. Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an Aml Diagnostic Sample Containing the T(8;21) Translocation. Stem Cells. 2015.

Heinz N, Ehrnstrom B, Schambach A, Schwarzer A, Modlich U, Schiedlmeier B. Comparison of Different Cytokine Conditions Reveals Resveratrol as a New Molecule for Ex Vivo Cultivation of Cord Blood-Derived Hematopoietic Stem Cells. Stem Cells Transl Med. 2015;4(9):1064-72. Epub 2015/07/15.

Glienke W, Esser R, Priesner C, Suerth JD, Schambach A, Wels WS, Grez M, Kloess S, Arseniev L, Koehl U. Advantages and Applications of Car-Expressing Natural Killer Cells. Front Pharmacol. 2015;6:21.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T. Talen-Mediated Functional Correction of X-Linked Chronic Granulomatous Disease in Patient-Derived Induced Pluripotent Stem Cells. Biomaterials. 2015;69:191-200.

Dobbs K, Dominguez Conde C, Zhang SY, Parolini S, Audry M, Chou J, Haapaniemi E, Keles S, Bilic I, Okada S, Massaad MJ, Rounioja S, Alwahadneh AM, Serwas NK, Capuder K, Ciftci E, Felgentreff K, Ohsumi TK, Pedergnana V, Boisson B, Haskologlu S, Ensari A, Schuster M, Moretta A, Itan Y, Patrizi O, Rozenberg F, Lebon P, Saarela J, Knip M, Petrovski S, Goldstein DB, Parrott RE, Savas B, Schambach A, Tabellini G, Bock C, Chatila TA, Comeau AM, Geha RS, Abel L, Buckley RH, Ikinciogullari A, Al-Herz W, Helminen M, Dogu F, Casanova JL, Boztug K, Notarangelo LD. Inherited Dock2 Deficiency in Patients with Early-Onset Invasive Infections. N Engl J Med. 2015;372(25):2409-22.

Dahl M, Doyle A, Olsson K, Mansson JE, Marques AR, Mirzaian M, Aerts JM, Ehinger M, Rothe M, Modlich U, Schambach A, Karlsson S. Lentiviral Gene Therapy Using Cellular Promoters Cures Type 1 Gaucher Disease in Mice. Mol Ther. 2015;23(5):835-44. Epub 2015/02/07.

Carmo M, Risma KA, Arumugam P, Tiwari S, Hontz AE, Montiel-Equihua CA, Alonso-Ferrero ME, Blundell MP, Schambach A, Baum C, Malik P, Thrasher AJ, Jordan MB, Gaspar HB. Perforin Gene Transfer into Hematopoietic Stem Cells Improves Immune Dysregulation in Murine Models of Perforin Deficiency. Mol Ther. 2015;23(4):737-45. Epub 2014/12/20.

Zhang H, Goudeva L, Immenschuh S, Schambach A, Skokowa J, Eiz-Vesper B, Blasczyk R, Figueiredo C. Mir-155 Is Associated with the Leukemogenic Potential of the Class Iv Granulocyte Colony-Stimulating Factor Receptor in Cd34(+) Progenitor Cells. Mol Med. 2014;20:736-46. Epub 2015/03/03.

2014

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9.

Suerth JD, Labenski V, Schambach A. Alpharetroviral Vectors: From a Cancer-Causing Agent to a Useful Tool for Human Gene Therapy. Viruses. 2014;6(12):4811-38.

Rothe M, Schambach A, Biasco L. Safety of Gene Therapy: New Insights to a Puzzling Case. Curr Gene Ther. 2014;14(6):429-36.

Pike-Overzet K, Baum C, Bredius RG, Cavazzana M, Driessen GJ, Fibbe WE, Gaspar HB, Hoeben RC, Lagresle-Peyrou C, Lankester A, Meij P, Schambach A, Thrasher A, Van Dongen JJ, Zwaginga JJ, Staal FJ. Successful Rag1-Scid Gene Therapy Depends on the Level of Rag1 Expression. J Allergy Clin Immunol. 2014;134(1):242-3.

Moiani A, Suerth JD, Gandolfi F, Rizzi E, Severgnini M, De Bellis G, Schambach A, Mavilio F. Genome-Wide Analysis of Alpharetroviral Integration in Human Hematopoietic Stem/Progenitor Cells. Genes (Basel). 2014;5(2):415-29.

Maetzig T, Kuehle J, Schwarzer A, Turan S, Rothe M, Chaturvedi A, Morgan M, Ha TC, Heuser M, Hammerschmidt W, Baum C, Schambach A. All-in-One Inducible Lentiviral Vector Systems Based on Drug Controlled Flp Recombinase. Biomaterials. 2014;35(14):4345-56.

Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. Transcriptional Pause Release Is a Rate-Limiting Step for Somatic Cell Reprogramming. Cell Stem Cell. 2014;15(5):574-88.

Limbourg A, Schnabel S, Lozanovski VJ, Napp LC, Ha TC, Maetzig T, Bauersachs J, Naim HY, Schambach A, Limbourg FP. Genetic Reporter Analysis Reveals an Expandable Reservoir of Oct4+ Cells in Adult Skin. Cell Regen (Lond). 2014;3(1):9.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Kuehle J, Turan S, Cantz T, Hoffmann D, Suerth JD, Maetzig T, Zychlinski D, Klein C, Steinemann D, Baum C, Bode J, Schambach A. Modified Lentiviral Ltrs Allow Flp Recombinase-Mediated Cassette Exchange and in Vivo Tracing of "Factor-Free" Induced Pluripotent Stem Cells. Mol Ther. 2014;22(5):919-28.

Jaako P, Debnath S, Olsson K, Modlich U, Rothe M, Schambach A, Flygare J, Karlsson S. Gene Therapy Cures the Anemia and Lethal Bone Marrow Failure in a Mouse Model of Rps19-Deficient Diamond-Blackfan Anemia. Haematologica. 2014;99(12):1792-8.

Huang J, Guo X, Fan N, Song J, Zhao B, Ouyang Z, Liu Z, Zhao Y, Yan Q, Yi X, Schambach A, Frampton J, Esteban MA, Yang D, Yang H, Lai L. Rag1/2 Knockout Pigs with Severe Combined Immunodeficiency. J Immunol. 2014;193(3):1496-503.

Haemmerle R, Phaltane R, Rothe M, Schroder S, Schambach A, Moritz T, Modlich U. Clonal Dominance with Retroviral Vector Insertions near the Angpt1 and Angpt2 Genes in a Human Xenotransplant Mouse Model. Mol Ther Nucleic Acids. 2014;3:e200.

Hacein-Bey-Abina S, Pai SY, Gaspar HB, Armant M, Berry CC, Blanche S, Bleesing J, Blondeau J, de Boer H, Buckland KF, Caccavelli L, Cros G, De Oliveira S, Fernandez KS, Guo D, Harris CE, Hopkins G, Lehmann LE, Lim A, London WB, van der Loo JC, Malani N, Male F, Malik P, Marinovic MA, McNicol AM, Moshous D, Neven B, Oleastro M, Picard C, Ritz J, Rivat C, Schambach A, Shaw KL, Sherman EA, Silberstein LE, Six E, Touzot F, Tsytsykova A, Xu-Bayford J, Baum C, Bushman FD, Fischer A, Kohn DB, Filipovich AH, Notarangelo LD, Cavazzana M, Williams DA, Thrasher AJ. A Modified Gamma-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency. N Engl J Med. 2014;371(15):1407-17. Epub 2014/10/09.

Felgentreff K, Du L, Weinacht KG, Dobbs K, Bartish M, Giliani S, Schlaeger T, DeVine A, Schambach A, Woodbine LJ, Davies G, Baxi SN, van der Burg M, Bleesing J, Gennery A, Manis J, Pan-Hammarstrom Q, Notarangelo LD. Differential Role of Nonhomologous End Joining Factors in the Generation, DNA Damage Response, and Myeloid Differentiation of Human Induced Pluripotent Stem Cells. Proc Natl Acad Sci U S A. 2014;111(24):8889-94.

Braun CJ, Boztug K, Paruzynski A, Witzel M, Schwarzer A, Rothe M, Modlich U, Beier R, Gohring G, Steinemann D, Fronza R, Ball CR, Haemmerle R, Naundorf S, Kuhlcke K, Rose M, Fraser C, Mathias L, Ferrari R, Abboud MR, Al-Herz W, Kondratenko I, Marodi L, Glimm H, Schlegelberger B, Schambach A, Albert MH, Schmidt M, von Kalle C, Klein C. Gene Therapy for Wiskott-Aldrich Syndrome--Long-Term Efficacy and Genotoxicity. Sci Transl Med. 2014;6(227):227ra33.

Bobis-Wozowicz S, Galla M, Alzubi J, Kuehle J, Baum C, Schambach A, Cathomen T. Non-Integrating Gamma-Retroviral Vectors as a Versatile Tool for Transient Zinc-Finger Nuclease Delivery. Sci Rep. 2014;4:4656.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

2013

Sundarasetty BS, Singh VK, Salguero G, Geffers R, Rickmann M, Macke L, Borchers S, Figueiredo C, Schambach A, Gullberg U, Provasi E, Bonini C, Ganser A, Woelfel T, Stripecke R. Lentivirus-Induced Dendritic Cells for Immunization against High-Risk Wt1(+) Acute Myeloid Leukemia. Hum Gene Ther. 2013;24(2):220-37.

Stein S, Scholz S, Schwable J, Sadat MA, Modlich U, Schultze-Strasser S, Diaz M, Chen-Wichmann L, Muller-Kuller U, Brendel C, Fronza R, Kaufmann KB, Naundorf S, Pech NK, Travers JB, Matute JD, Presson RG, Jr., Sandusky GE, Kunkel H, Rudolf E, Dillmann A, von Kalle C, Kuhlcke K, Baum C, Schambach A, Dinauer MC, Schmidt M, Grez M. From Bench to Bedside: Preclinical Evaluation of a Self-Inactivating Gammaretroviral Vector for the Gene Therapy of X-Linked Chronic Granulomatous Disease. Hum Gene Ther Clin Dev. 2013;24(2):86-98.

Sgodda M, Mobus S, Hoepfner J, Sharma AD, Schambach A, Greber B, Ott M, Cantz T. Improved Hepatic Differentiation Strategies for Human Induced Pluripotent Stem Cells. Curr Mol Med. 2013;13(5):842-55.

Schambach A, Moritz T. Toward Position-Independent Retroviral Vector Expression in Pluripotent Stem Cells. Mol Ther. 2013;21(8):1474-7.

Rothe M, Modlich U, Schambach A. Biosafety Challenges for Use of Lentiviral Vectors in Gene Therapy. Curr Gene Ther. 2013;13(6):453-68.

Rittelmeyer I, Rothe M, Brugman MH, Iken M, Schambach A, Manns MP, Baum C, Modlich U, Ott M. Hepatic Lentiviral Gene Transfer Is Associated with Clonal Selection, but Not with Tumor Formation in Serially Transplanted Rodents. Hepatology. 2013;58(1):397-408.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. A Ubiquitous Chromatin Opening Element Prevents Transgene Silencing in Pluripotent Stem Cells and Their Differentiated Progeny. Stem Cells. 2013;31(3):488-99.

Lachmann N, Brennig S, Pfaff N, Schermeier H, Dahlmann J, Phaltane R, Gruh I, Modlich U, Schambach A, Baum C, Moritz T. Efficient in Vivo Regulation of Cytidine Deaminase Expression in the Haematopoietic System Using a Doxycycline-Inducible Lentiviral Vector System. Gene Ther. 2013;20(3):298-307.

Kustikova OS, Schwarzer A, Stahlhut M, Brugman MH, Neumann T, Yang M, Li Z, Schambach A, Heinz N, Gerdes S, Roeder I, Ha TC, Steinemann D, Schlegelberger B, Baum C. Activation of Evi1 Inhibits Cell Cycle Progression and Differentiation of Hematopoietic Progenitor Cells. Leukemia. 2013;27(5):1127-38.

Kaufmann KB, Buning H, Galy A, Schambach A, Grez M. Gene Therapy on the Move. EMBO Mol Med. 2013;5(11):1642-61.

Kaufmann KB, Brendel C, Suerth JD, Mueller-Kuller U, Chen-Wichmann L, Schwable J, Pahujani S, Kunkel H, Schambach A, Baum C, Grez M. Alpharetroviral Vector-Mediated Gene Therapy for X-Cgd: Functional Correction and Lack of Aberrant Splicing. Mol Ther. 2013;21(3):648-61.

Hauber I, Hofmann-Sieber H, Chemnitz J, Dubrau D, Chusainow J, Stucka R, Hartjen P, Schambach A, Ziegler P, Hackmann K, Schrock E, Schumacher U, Lindner C, Grundhoff A, Baum C, Manz MG, Buchholz F, Hauber J. Highly Significant Antiviral Activity of Hiv-1 Ltr-Specific Tre-Recombinase in Humanized Mice. PLoS Pathog. 2013;9(9):e1003587.

Gupta SS, Maetzig T, Maertens GN, Sharif A, Rothe M, Weidner-Glunde M, Galla M, Schambach A, Cherepanov P, Schulz TF. Bromo- and Extraterminal Domain Chromatin Regulators Serve as Cofactors for Murine Leukemia Virus Integration. J Virol. 2013;87(23):12721-36.

Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemann D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvak Z, Sarkadi B, Ivics Z. Sleeping Beauty Transposon-Based System for Cellular Reprogramming and Targeted Gene Insertion in Induced Pluripotent Stem Cells. Nucleic Acids Res. 2013;41(3):1829-47.

Galla M, Schambach A, Baum C. Retrovirus-Based Mrna Transfer for Transient Cell Manipulation. Methods Mol Biol. 2013;969:139-61.

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med. 2013;2(9):641-54.

Brugman MH, Suerth JD, Rothe M, Suerbaum S, Schambach A, Modlich U, Kustikova O, Baum C. Evaluating a Ligation-Mediated Pcr and Pyrosequencing Method for the Detection of Clonal Contribution in Polyclonal Retrovirally Transduced Samples. Hum Gene Ther Methods. 2013;24(2):68-79.

2012

Zhou Q, Schneider IC, Edes I, Honegger A, Bach P, Schonfeld K, Schambach A, Wels WS, Kneissl S, Uckert W, Buchholz CJ. T-Cell Receptor Gene Transfer Exclusively to Human Cd8(+) Cells Enhances Tumor Cell Killing. Blood. 2012;120(22):4334-42.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84.

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Weinacht KG, Brauer PM, Felgentreff K, Devine A, Gennery AR, Giliani S, Al-Herz W, Schambach A, Zuniga-Pflucker JC, Notarangelo LD. The Role of Induced Pluripotent Stem Cells in Research and Therapy of Primary Immunodeficiencies. Curr Opin Immunol. 2012;24(5):617-24.

Wang J, Sun Q, Morita Y, Jiang H, Gross A, Lechel A, Hildner K, Guachalla LM, Gompf A, Hartmann D, Schambach A, Wuestefeld T, Dauch D, Schrezenmeier H, Hofmann WK, Nakauchi H, Ju Z, Kestler HA, Zender L, Rudolph KL. A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage. Cell. 2012;148(5):1001-14.

Voelkel C, Galla M, Dannhauser PN, Maetzig T, Sodeik B, Schambach A, Baum C. Pseudotype-Independent Nonspecific Uptake of Gammaretroviral and Lentiviral Particles in Human Cells. Hum Gene Ther. 2012;23(3):274-86.

van der Loo JC, Swaney WP, Grassman E, Terwilliger A, Higashimoto T, Schambach A, Hacein-Bey-Abina S, Nordling DL, Cavazzana-Calvo M, Thrasher AJ, Williams DA, Reeves L, Malik P. Critical Variables Affecting Clinical-Grade Production of the Self-Inactivating Gamma-Retroviral Vector for the Treatment of X-Linked Severe Combined Immunodeficiency. Gene Ther. 2012;19(8):872-6.

van der Loo JC, Swaney WP, Grassman E, Terwilliger A, Higashimoto T, Schambach A, Baum C, Thrasher AJ, Williams DA, Nordling DL, Reeves L, Malik P. Scale-up and Manufacturing of Clinical-Grade Self-Inactivating Gamma-Retroviral Vectors by Transient Transfection. Gene Ther. 2012;19(3):246-54.

Thol F, Yun H, Sonntag AK, Damm F, Weissinger EM, Krauter J, Wagner K, Morgan M, Wichmann M, Gohring G, Bug G, Ottmann O, Hofmann WK, Schambach A, Schlegelberger B, Haferlach T, Bowen D, Mills K, Ganser A, Heuser M. Prognostic Significance of Combined Mn1, Erg, Baalc, and Evi1 (Mebe) Expression in Patients with Myelodysplastic Syndromes. Ann Hematol. 2012;91(8):1221-33.

Suerth JD, Schambach A, Baum C. Genetic Modification of Lymphocytes by Retrovirus-Based Vectors. Curr Opin Immunol. 2012;24(5):598-608.

Suerth JD, Maetzig T, Brugman MH, Heinz N, Appelt JU, Kaufmann KB, Schmidt M, Grez M, Modlich U, Baum C, Schambach A. Alpharetroviral Self-Inactivating Vectors: Long-Term Transgene Expression in Murine Hematopoietic Cells and Low Genotoxicity. Mol Ther. 2012;20(5):1022-32.

Schambach A, Baum C. Vectorizing Mrna and Proteins. Curr Gene Ther. 2012;12(5):345-6.

Rothe M, Rittelmeyer I, Iken M, Rudrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U. Epidermal Growth Factor Improves Lentivirus Vector Gene Transfer into Primary Mouse Hepatocytes. Gene Ther. 2012;19(4):425-34.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Otte A, Gohring G, Steinemann D, Schlegelberger B, Groos S, Langer F, Kreipe HH, Schambach A, Neumann T, Hillemanns P, Park-Simon TW, Hass R. A Tumor-Derived Population (Sccoht-1) as Cellular Model for a Small Cell Ovarian Carcinoma of the Hypercalcemic Type. Int J Oncol. 2012;41(2):765-75.

Muller LU, Milsom MD, Harris CE, Vyas R, Brumme KM, Parmar K, Moreau LA, Schambach A, Park IH, London WB, Strait K, Schlaeger T, Devine AL, Grassman E, D'Andrea A, Daley GQ, Williams DA. Overcoming Reprogramming Resistance of Fanconi Anemia Cells. Blood. 2012;119(23):5449-57.

Maetzig T, Baum C, Schambach A. Retroviral Protein Transfer: Falling Apart to Make an Impact. Curr Gene Ther. 2012;12(5):389-409.

Li W, Wang X, Fan W, Zhao P, Chan YC, Chen S, Zhang S, Guo X, Zhang Y, Li Y, Cai J, Qin D, Li X, Yang J, Peng T, Zychlinski D, Hoffmann D, Zhang R, Deng K, Ng KM, Menten B, Zhong M, Wu J, Li Z, Chen Y, Schambach A, Tse HF, Pei D, Esteban MA. Modeling Abnormal Early Development with Induced Pluripotent Stem Cells from Aneuploid Syndromes. Hum Mol Genet. 2012;21(1):32-45.

Lachmann N, Jagielska J, Heckl D, Brennig S, Pfaff N, Maetzig T, Modlich U, Cantz T, Gentner B, Schambach A, Moritz T. Microrna-150-Regulated Vectors Allow Lymphocyte-Sparing Transgene Expression in Hematopoietic Gene Therapy. Gene Ther. 2012;19(9):915-24.

Koch L, Deiwick A, Schlie S, Michael S, Gruene M, Coger V, Zychlinski D, Schambach A, Reimers K, Vogt PM, Chichkov B. Skin Tissue Generation by Laser Cell Printing. Biotechnol Bioeng. 2012;109(7):1855-63.

Knippenberg S, Thau N, Schwabe K, Dengler R, Schambach A, Hass R, Petri S. Intraspinal Injection of Human Umbilical Cord Blood-Derived Cells Is Neuroprotective in a Transgenic Mouse Model of Amyotrophic Lateral Sclerosis. Neurodegener Dis. 2012;9(3):107-20.

Geiger H, Pawar SA, Kerschen EJ, Nattamai KJ, Hernandez I, Liang HP, Fernandez JA, Cancelas JA, Ryan MA, Kustikova O, Schambach A, Fu Q, Wang J, Fink LM, Petersen KU, Zhou D, Griffin JH, Baum C, Weiler H, Hauer-Jensen M. Pharmacological Targeting of the Thrombomodulin-Activated Protein C Pathway Mitigates Radiation Toxicity. Nat Med. 2012;18(7):1123-9.

Gaussin A, Modlich U, Bauche C, Niederlander NJ, Schambach A, Duros C, Artus A, Baum C, Cohen-Haguenauer O, Mermod N. Ctf/Nf1 Transcription Factors Act as Potent Genetic Insulators for Integrating Gene Transfer Vectors. Gene Ther. 2012;19(1):15-24.

Foll D, Hinrichs J, Tischer S, Battermann A, Schambach A, Figueiredo C, Immenschuh S, Blasczyk R, Eiz-Vesper B. Closing the Gap: Discrimination of the Expression Profile of Hla Questionable Alleles by a Cytokine-Induced Secretion Approach Using Hla-a*32:11q. Tissue Antigens. 2012;79(5):340-50.

Daenthanasanmak A, Salguero G, Borchers S, Figueiredo C, Jacobs R, Sundarasetty BS, Schneider A, Schambach A, Eiz-Vesper B, Blasczyk R, Weissinger EM, Ganser A, Stripecke R. Integrase-Defective Lentiviral Vectors Encoding Cytokines Induce Differentiation of Human Dendritic Cells and Stimulate Multivalent Immune Responses in Vitro and in Vivo. Vaccine. 2012;30(34):5118-31.

Brennig S, Rattmann I, Lachmann N, Schambach A, Williams DA, Moritz T. In Vivo Enrichment of Cytidine Deaminase Gene-Modified Hematopoietic Cells by Prolonged Cytosine-Arabinoside Application. Cytotherapy. 2012;14(4):451-60.

Baum C. Conditional Negative Selection of Gene-Modified Hematopoietic Stem Cells. Mol Ther. 2012;20(10):1841-2.

Abdollahpour H, Appaswamy G, Kotlarz D, Diestelhorst J, Beier R, Schaffer AA, Gertz EM, Schambach A, Kreipe HH, Pfeifer D, Engelhardt KR, Rezaei N, Grimbacher B, Lohrmann S, Sherkat R, Klein C. The Phenotype of Human Stk4 Deficiency. Blood. 2012;119(15):3450-7.

2011

Zhang S, Chen S, Li W, Guo X, Zhao P, Xu J, Chen Y, Pan Q, Liu X, Zychlinski D, Lu H, Tortorella MD, Schambach A, Wang Y, Pei D, Esteban MA. Rescue of Atp7b Function in Hepatocyte-Like Cells from Wilson's Disease Induced Pluripotent Stem Cells Using Gene Therapy or the Chaperone Drug Curcumin. Hum Mol Genet. 2011;20(16):3176-87.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011;9(7):e1001099.

Warlich E, Kuehle J, Cantz T, Brugman MH, Maetzig T, Galla M, Filipczyk AA, Halle S, Klump H, Scholer HR, Baum C, Schroeder T, Schambach A. Lentiviral Vector Design and Imaging Approaches to Visualize the Early Stages of Cellular Reprogramming. Mol Ther. 2011;19(4):782-9.

Tiemann U, Sgodda M, Warlich E, Ballmaier M, Scholer HR, Schambach A, Cantz T. Optimal Reprogramming Factor Stoichiometry Increases Colony Numbers and Affects Molecular Characteristics of Murine Induced Pluripotent Stem Cells. Cytometry A. 2011;79(6):426-35.

Schott JW, Galla M, Godinho T, Baum C, Schambach A. Viral and Non-Viral Approaches for Transient Delivery of Mrna and Proteins. Curr Gene Ther. 2011;11(5):382-98.

Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Busche G, Ganser A, Stripecke R. Lentiviral Vectors for Induction of Self-Differentiation and Conditional Ablation of Dendritic Cells. Gene Ther. 2011;18(8):750-64.

Pike-Overzet K, Rodijk M, Ng YY, Baert MR, Lagresle-Peyrou C, Schambach A, Zhang F, Hoeben RC, Hacein-Bey-Abina S, Lankester AC, Bredius RG, Driessen GJ, Thrasher AJ, Baum C, Cavazzana-Calvo M, van Dongen JJ, Staal FJ. Correction of Murine Rag1 Deficiency by Self-Inactivating Lentiviral Vector-Mediated Gene Transfer. Leukemia. 2011;25(9):1471-83.

Pfaff N, Fiedler J, Holzmann A, Schambach A, Moritz T, Cantz T, Thum T. Mirna Screening Reveals a New Mirna Family Stimulating Ips Cell Generation Via Regulation of Meox2. EMBO Rep. 2011;12(11):1153-9.

Maetzig T, Galla M, Baum C, Schambach A. Gammaretroviral Vectors: Biology, Technology and Application. Viruses. 2011;3(6):677-713.

Maetzig T, Brugman MH, Bartels S, Heinz N, Kustikova OS, Modlich U, Li Z, Galla M, Schiedlmeier B, Schambach A, Baum C. Polyclonal Fluctuation of Lentiviral Vector-Transduced and Expanded Murine Hematopoietic Stem Cells. Blood. 2011;117(11):3053-64.

Jaako P, Flygare J, Olsson K, Quere R, Ehinger M, Henson A, Ellis S, Schambach A, Baum C, Richter J, Larsson J, Bryder D, Karlsson S. Mice with Ribosomal Protein S19 Deficiency Develop Bone Marrow Failure and Symptoms Like Patients with Diamond-Blackfan Anemia. Blood. 2011;118(23):6087-96.

Iacob R, Rudrich U, Rothe M, Kirsch S, Maasoumy B, Narain N, Verfaillie CM, Sancho-Bru P, Iken M, Popescu I, Schambach A, Manns MP, Bock M. Induction of a Mature Hepatocyte Phenotype in Adult Liver Derived Progenitor Cells by Ectopic Expression of Transcription Factors. Stem Cell Res. 2011;6(3):251-61.

Huston MW, van Til NP, Visser TP, Arshad S, Brugman MH, Cattoglio C, Nowrouzi A, Li Y, Schambach A, Schmidt M, Baum C, von Kalle C, Mavilio F, Zhang F, Blundell MP, Thrasher AJ, Verstegen MM, Wagemaker G. Correction of Murine Scid-X1 by Lentiviral Gene Therapy Using a Codon-Optimized Il2rg Gene and Minimal Pretransplant Conditioning. Mol Ther. 2011;19(10):1867-77.

Huelsmann PM, Hofmann AD, Knoepfel SA, Popp J, Rauch P, Di Giallonardo F, Danke C, Gueckel E, Schambach A, Wolff H, Metzner KJ, Berens C. A Suicide Gene Approach Using the Human Pro-Apoptotic Protein Tbid Inhibits Hiv-1 Replication. BMC Biotechnol. 2011;11:4.

Heinz N, Schambach A, Galla M, Maetzig T, Baum C, Loew R, Schiedlmeier B. Retroviral and Transposon-Based Tet-Regulated All-in-One Vectors with Reduced Background Expression and Improved Dynamic Range. Hum Gene Ther. 2011;22(2):166-76.

Heckl D, Wicke DC, Brugman MH, Meyer J, Schambach A, Busche G, Ballmaier M, Baum C, Modlich U. Lentiviral Gene Transfer Regenerates Hematopoietic Stem Cells in a Mouse Model for Mpl-Deficient Aplastic Anemia. Blood. 2011;117(14):3737-47.

Galla M, Schambach A, Falk CS, Maetzig T, Kuehle J, Lange K, Zychlinski D, Heinz N, Brugman MH, Gohring G, Izsvak Z, Ivics Z, Baum C. Avoiding Cytotoxicity of Transposases by Dose-Controlled Mrna Delivery. Nucleic Acids Res. 2011;39(16):7147-60.

Baum C, Schambach A. Promoter Competition for Gene Therapy of Scid-X1. Hum Gene Ther. 2011;22(3):255-6.

Baum C, Modlich U, Gohring G, Schlegelberger B. Concise Review: Managing Genotoxicity in the Therapeutic Modification of Stem Cells. Stem Cells. 2011;29(10):1479-84.

Baum C. Gene Therapy for Scid-X1: Focus on Clinical Data. Mol Ther. 2011;19(12):2103-4.

Bals C, Schambach A, Meyer J, Scheper T, Rinas U. Expression and Purification of Bioactive Soluble Murine Stem Cell Factor from Recombinant Escherichia Coli Using Thioredoxin as Fusion Partner. J Biotechnol. 2011;152(1-2):1-8.

Avedillo Diez I, Zychlinski D, Coci EG, Galla M, Modlich U, Dewey RA, Schwarzer A, Maetzig T, Mpofu N, Jaeckel E, Boztug K, Baum C, Klein C, Schambach A. Development of Novel Efficient Sin Vectors with Improved Safety Features for Wiskott-Aldrich Syndrome Stem Cell Based Gene Therapy. Mol Pharm. 2011;8(5):1525-37.

2010

Wurm M, Schambach A, Lindemann D, Hanenberg H, Standker L, Forssmann WG, Blasczyk R, Horn PA. The Influence of Semen-Derived Enhancer of Virus Infection on the Efficiency of Retroviral Gene Transfer. J Gene Med. 2010;12(2):137-46.

Voelkel C, Galla M, Maetzig T, Warlich E, Kuehle J, Zychlinski D, Bode J, Cantz T, Schambach A, Baum C. Protein Transduction from Retroviral Gag Precursors. Proc Natl Acad Sci U S A. 2010;107(17):7805-10.

Turan S, Kuehle J, Schambach A, Baum C, Bode J. Multiplexing Rmce: Versatile Extensions of the Flp-Recombinase-Mediated Cassette-Exchange Technology. J Mol Biol. 2010;402(1):52-69.

Tomala M, Lavrentieva A, Moretti P, Rinas U, Kasper C, Stahl F, Schambach A, Warlich E, Martin U, Cantz T, Scheper T. Preparation of Bioactive Soluble Human Leukemia Inhibitory Factor from Recombinant Escherichia Coli Using Thioredoxin as Fusion Partner. Protein Expr Purif. 2010;73(1):51-7.

Suerth JD, Maetzig T, Galla M, Baum C, Schambach A. Self-Inactivating Alpharetroviral Vectors with a Split-Packaging Design. J Virol. 2010;84(13):6626-35.

Schambach A, Cantz T, Baum C, Cathomen T. Generation and Genetic Modification of Induced Pluripotent Stem Cells. Expert Opin Biol Ther. 2010;10(7):1089-103.

Ng YY, Baert MR, Pike-Overzet K, Rodijk M, Brugman MH, Schambach A, Baum C, Hendriks RW, van Dongen JJ, Staal FJ. Correction of B-Cell Development in Btk-Deficient Mice Using Lentiviral Vectors with Codon-Optimized Human Btk. Leukemia. 2010;24(9):1617-30.

Metcalf JA, Ma X, Linders B, Wu S, Schambach A, Ohlemiller KK, Kovacs A, Bigg M, He L, Tollefsen DM, Ponder KP. A Self-Inactivating Gamma-Retroviral Vector Reduces Manifestations of Mucopolysaccharidosis I in Mice. Mol Ther. 2010;18(2):334-42.

Maetzig T, Galla M, Brugman MH, Loew R, Baum C, Schambach A. Mechanisms Controlling Titer and Expression of Bidirectional Lentiviral and Gammaretroviral Vectors. Gene Ther. 2010;17(3):400-11.

Loew R, Meyer Y, Kuehlcke K, Gama-Norton L, Wirth D, Hauser H, Stein S, Grez M, Thornhill S, Thrasher A, Baum C, Schambach A. A New Pg13-Based Packaging Cell Line for Stable Production of Clinical-Grade Self-Inactivating Gamma-Retroviral Vectors Using Targeted Integration. Gene Therapy. 2010;17(2):272-80.

Gama-Norton L, Herrmann S, Schucht R, Coroadinha AS, Low R, Alves PM, Bartholomae CC, Schmidt M, Baum C, Schambach A, Hauser H, Wirth D. Retroviral Vector Performance in Defined Chromosomal Loci of Modular Packaging Cell Lines. Hum Gene Ther. 2010;21(8):979-91.

Cathomen T, Schambach A. Zinc-Finger Nucleases Meet Ips Cells: Zinc Positive: Tailored Genome Engineering Meets Reprogramming. Gene Ther. 2010;17(1):1-3.

Broll S, Oumard A, Hahn K, Schambach A, Bode J. Minicircle Performance Depending on S/Mar-Nuclear Matrix Interactions. J Mol Biol. 2010;395(5):950-65.

2009

Skokowa J, Lan D, Thakur BK, Wang F, Gupta K, Cario G, Brechlin AM, Schambach A, Hinrichsen L, Meyer G, Gaestel M, Stanulla M, Tong Q, Welte K. Nampt Is Essential for the G-Csf-Induced Myeloid Differentiation Via a Nad(+)-Sirtuin-1-Dependent Pathway. Nat Med. 2009;15(2):151-8.

Schambach A, Swaney WP, van der Loo JC. Design and Production of Retro- and Lentiviral Vectors for Gene Expression in Hematopoietic Cells. Methods Mol Biol. 2009;506:191-205.

Pauwels K, Gijsbers R, Toelen J, Schambach A, Willard-Gallo K, Verheust C, Debyser Z, Herman P. State-of-the-Art Lentiviral Vectors for Research Use: Risk Assessment and Biosafety Recommendations. Curr Gene Ther. 2009;9(6):459-74.

Moreno-Carranza B, Gentsch M, Stein S, Schambach A, Santilli G, Rudolf E, Ryser MF, Haria S, Thrasher AJ, Baum C, Brenner S, Grez M. Transgene Optimization Significantly Improves Sin Vector Titers, Gp91phox Expression and Reconstitution of Superoxide Production in X-Cgd Cells. Gene Ther. 2009;16(1):111-8.

Modlich U, Schambach A, Li Z, Schiedlmeier B. Murine Hematopoietic Stem Cell Transduction Using Retroviral Vectors. Methods Mol Biol. 2009;506:23-31.

Modlich U, Navarro S, Zychlinski D, Maetzig T, Knoess S, Brugman MH, Schambach A, Charrier S, Galy A, Thrasher AJ, Bueren J, Baum C. Insertional Transformation of Hematopoietic Cells by Self-Inactivating Lentiviral and Gammaretroviral Vectors. Mol Ther. 2009;17(11):1919-28.

Maruggi G, Porcellini S, Facchini G, Perna SK, Cattoglio C, Sartori D, Ambrosi A, Schambach A, Baum C, Bonini C, Bovolenta C, Mavilio F, Recchia A. Transcriptional Enhancers Induce Insertional Gene Deregulation Independently from the Vector Type and Design. Mol Ther. 2009;17(5):851-6.

Cornils K, Lange C, Schambach A, Brugman MH, Nowak R, Lioznov M, Baum C, Fehse B. Stem Cell Marking with Promotor-Deprived Self-Inactivating Retroviral Vectors Does Not Lead to Induced Clonal Imbalance. Mol Ther. 2009;17(1):131-43.

2008

Zychlinski D, Schambach A, Modlich U, Maetzig T, Meyer J, Grassman E, Mishra A, Baum C. Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors. Mol Ther. 2008;16(4):718-25.

Thornhill SI, Schambach A, Howe SJ, Ulaganathan M, Grassman E, Williams D, Schiedlmeier B, Sebire NJ, Gaspar HB, Kinnon C, Baum C, Thrasher AJ. Self-Inactivating Gammaretroviral Vectors for Gene Therapy of X-Linked Severe Combined Immunodeficiency. Mol Ther. 2008;16(3):590-8.

Sharma AD, Cantz T, Vogel A, Schambach A, Haridass D, Iken M, Bleidissel M, Manns MP, Scholer HR, Ott M. Murine Embryonic Stem Cell-Derived Hepatic Progenitor Cells Engraft in Recipient Livers with Limited Capacity of Liver Tissue Formation. Cell Transplant. 2008;17(3):313-23.

Schambach A, Baum C. Clinical Application of Lentiviral Vectors - Concepts and Practice. Curr Gene Ther. 2008;8(6):474-82.

Muller LU, Milsom MD, Kim MO, Schambach A, Schuesler T, Williams DA. Rapid Lentiviral Transduction Preserves the Engraftment Potential of Fanca(-/-) Hematopoietic Stem Cells. Mol Ther. 2008;16(6):1154-60.

Modlich U, Schambach A, Brugman MH, Wicke DC, Knoess S, Li Z, Maetzig T, Rudolph C, Schlegelberger B, Baum C. Leukemia Induction after a Single Retroviral Vector Insertion in Evi1 or Prdm16. Leukemia. 2008;22(8):1519-28.

Milsom MD, Jerabek-Willemsen M, Harris CE, Schambach A, Broun E, Bailey J, Jansen M, Schleimer D, Nattamai K, Wilhelm J, Watson A, Geiger H, Margison GP, Moritz T, Baum C, Thomale J, Williams DA. Reciprocal Relationship between O6-Methylguanine-DNA Methyltransferase P140k Expression Level and Chemoprotection of Hematopoietic Stem Cells. Cancer Res. 2008;68(15):6171-80.

2007

Zhang F, Thornhill SI, Howe SJ, Ulaganathan M, Schambach A, Sinclair J, Kinnon C, Gaspar HB, Antoniou M, Thrasher AJ. Lentiviral Vectors Containing an Enhancer-Less Ubiquitously Acting Chromatin Opening Element (Ucoe) Provide Highly Reproducible and Stable Transgene Expression in Hematopoietic Cells. Blood. 2007;110(5):1448-57.

Schambach A, Galla M, Maetzig T, Loew R, Baum C. Improving Transcriptional Termination of Self-Inactivating Gamma-Retroviral and Lentiviral Vectors. Mol Ther. 2007;15(6):1167-73.

Schambach A, Baum C. Vector Design for Expression of O6-Methylguanine-DNA Methyltransferase in Hematopoietic Cells. DNA Repair (Amst). 2007;6(8):1187-96.

Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, Schlenk RF, Dohner K, Hinrichsen T, Rudolph C, Schambach A, Baum C, Schlegelberger B, Dohner H, Ganser A, Humphries RK. Mn1 Overexpression Induces Acute Myeloid Leukemia in Mice and Predicts Atra Resistance in Patients with Aml. Blood. 2007;110(5):1639-47.

Baum C, Schambach A, Modlich U, Thrasher A. [Gene Therapy of Scid-X1]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2007;50(12):1507-17. Gentherapie der SCID-X1.

Unit 6.3 - Tolerogenic Cell Therapy

2016

Borger AK, Eicke D, Wolf C, Gras C, Aufderbeck S, Schulze K, Engels L, Eiz-Vesper B, Schambach A, Guzman CA, Lachmann N, Moritz T, Martin U, Blasczyk R, Figueiredo C. Generation of HLA-universal iPSCs-derived megakaryocytes and platelets for survival under refractoriness conditions. Molecular medicine. 2016;22.

2015

Bunse CE, Fortmeier V, Tischer S, Zilian E, Figueiredo C, Witte T, Blasczyk R, Immenschuh S, Eiz-Vesper B. Modulation of Heme Oxygenase-1 by Metalloporphyrins Increases Anti-Viral T Cell Responses. Clin Exp Immunol. 2015;179(2):265-76.

Ratuszny D, Gras C, Bajor A, Borger AK, Pielen A, Borgel M, Framme C, Blasczyk R, Figueiredo C. Mir-145 Is a Promising Therapeutic Target to Prevent Cornea Scarring. Hum Gene Ther. 2015;26(10):698-707. Epub 2015/07/15.

Gras C, Ratuszny D, Hadamitzky C, Zhang H, Blasczyk R, Figueiredo C. Mir-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity. Mol Med. 2015;21:296-304.

Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Luttge D, Buchegger T, Kuhnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T. Large-Scale Hematopoietic Differentiation of Human Induced Pluripotent Stem Cells Provides Granulocytes or Macrophages for Cell Replacement Therapies. Stem Cell Reports. 2015;4(2):282-96.

Sundarasetty BS, Kloess S, Oberschmidt O, Naundorf S, Kuehlcke K, Daenthanasanmak A, Gerasch L, Figueiredo C, Blasczyk R, Ruggiero E, Fronza R, Schmidt M, von Kalle C, Rothe M, Ganser A, Koehl U, Stripecke R. Generation of Lentivirus-Induced Dendritic Cells under Gmp-Compliant Conditions for Adaptive Immune Reconstitution against Cytomegalovirus after Stem Cell Transplantation. J Transl Med. 2015;13:240.

Figueiredo C, Blasczyk R. A Future with Less Hla: Potential Clinical Applications of Hla-Universal Cells. Tissue Antigens. 2015;85(6):443-9.

Daenthanasanmak A, Salguero G, Sundarasetty BS, Waskow C, Cosgun KN, Guzman CA, Riese P, Gerasch L, Schneider A, Ingendoh A, Messerle M, Gabaev I, Woelk B, Ruggiero E, Schmidt M, von Kalle C, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, Stripecke R. Engineered Dendritic Cells from Cord Blood and Adult Blood Accelerate Effector T Cell Immune Reconstitution against Hcmv. Mol Ther Methods Clin Dev. 2015;1:14060.

Dorresteijn MJ, Paine A, Zilian E, Fenten MG, Frenzel E, Janciauskiene S, Figueiredo C, Eiz-Vesper B, Blasczyk R, Dekker D, Pennings B, Scharstuhl A, Smits P, Larmann J, Theilmeier G, van der Hoeven JG, Wagener FA, Pickkers P, Immenschuh S. Cell-Type-Specific Downregulation of Heme Oxygenase-1 by Lipopolysaccharide Via Bach1 in Primary Human Mononuclear Cells. Free Radic Biol Med. 2015;78:224-32.

2014

Muller T, Schlahsa L, Zhang HJ, Skaik Y, Eiz-Vesper B, Immenschuh S, Blasczyk R, Figueiredo C. Allogeneic and Xenogeneic Anti-Tumor Effect of Callithrix Jacchus Natural Killer Cells Is Dependent on Nkp30 and B7-H6 Interaction. J Biol Regul Homeost Agents. 2014;28(2):183-93.

Zhang H, Goudeva L, Immenschuh S, Schambach A, Skokowa J, Eiz-Vesper B, Blasczyk R, Figueiredo C. Mir-155 Is Associated with the Leukemogenic Potential of the Class Iv Granulocyte Colony-Stimulating Factor Receptor in Cd34(+) Progenitor Cells. Mol Med. 2014;20:736-46.

Gras C, Eiz-Vesper B, Jaimes Y, Immenschuh S, Jacobs R, Witte T, Blasczyk R, Figueiredo C. Secreted Semaphorin 5a Activates Immune Effector Cells and Is a Biomarker for Rheumatoid Arthritis. Arthritis Rheumatol. 2014;66(6):1461-71.

Saragih H, Zilian E, Jaimes Y, Paine A, Figueiredo C, Eiz-Vesper B, Blasczyk R, Larmann J, Theilmeier G, Burg-Roderfeld M, Andrei-Selmer LC, Becker JU, Santoso S, Immenschuh S. Pecam-1-Dependent Heme Oxygenase-1 Regulation Via an Nrf2-Mediated Pathway in Endothelial Cells. Thromb Haemost. 2014;111(6):1077-88.

Salguero G, Daenthanasanmak A, Munz C, Raykova A, Guzman CA, Riese P, Figueiredo C, Langer F, Schneider A, Macke L, Sundarasetty BS, Witte T, Ganser A, Stripecke R. Dendritic Cell-Mediated Immune Humanization of Mice: Implications for Allogeneic and Xenogeneic Stem Cell Transplantation. J Immunol. 2014;192(10):4636-47.

Tischer S, Dieks D, Sukdolak C, Bunse C, Figueiredo C, Immenschuh S, Borchers S, Stripecke R, Maecker-Kolhoff B, Blasczyk R, Eiz-Vesper B. Evaluation of Suitable Target Antigens and Immunoassays for High-Accuracy Immune Monitoring of Cytomegalovirus and Epstein-Barr Virus-Specific T Cells as Targets of Interest in Immunotherapeutic Approaches. J Immunol Methods. 2014;408:101-13.

Figueiredo C, Blaszczyk R. Genetically Engineered Blood Pharming: Generation of Hla-Universal Platelets Derived from Cd34+ Progenitor Cells. J Stem Cells. 2014;9(3):149-61.

Schlahsa L, Zhang H, Battermann A, Verboom M, Immenschuh S, Eiz-Vesper B, Stripecke R, Engelmann K, Blasczyk R, Figueiredo C. Semaphorin 3a Alters Endothelial Cell Immunogenicity by Regulating Class Ii Transactivator Activity Circuits. Transfusion. 2014;54(8):1961-70.

Wiegmann B, Figueiredo C, Gras C, Pflaum M, Schmeckebier S, Korossis S, Haverich A, Blasczyk R. Prevention of Rejection of Allogeneic Endothelial Cells in a Biohybrid Lung by Silencing Hla-Class I Expression. Biomaterials. 2014;35(28):8123-33.

Skaik Y, Vahlsing S, Goudeva L, Eiz-Vesper B, Battermann A, Blasczyk R, Figueiredo C. Secreted Β(3)-Integrin Enhances Natural Killer Cell Activity against Acute Myeloid Leukemia Cells. PLoS ONE. 2014;9(6):e98936.

2013

Gras C, Eiz-Vesper B, Seltsam A, Immenschuh S, Blasczyk R, Figueiredo C. Semaphorin 7a Protein Variants Differentially Regulate T-Cell Activity. Transfusion. 2013;53(2):270-83.

Sukdolak C, Tischer S, Dieks D, Figueiredo C, Goudeva L, Heuft HG, Verboom M, Immenschuh S, Heim A, Borchers S, Mischak-Weissinger E, Blasczyk R, Maecker-Kolhoff B, Eiz-Vesper B. Cmv-, Ebv- and Adv-Specific T Cell Immunity: Screening and Monitoring of Potential Third-Party Donors to Improve Post-Transplantation Outcome. Biol Blood Marrow Transplant. 2013;19(10):1480-92.

Skaik Y, Battermann A, Hiller O, Meyer O, Figueiredo C, Salama A, Blasczyk R. Development of a Single-Antigen Magnetic Bead Assay (Samba) for the Sensitive Detection of Hpa-1a Alloantibodies Using Tag-Engineered Recombinant Soluble Beta3 Integrin. J Immunol Methods. 2013;391(1-2):72-80.

Gras C, Schulze K, Goudeva L, Guzman CA, Blasczyk R, Figueiredo C. Hla-Universal Platelet Transfusions Prevent Platelet Refractoriness in a Mouse Model. Hum Gene Ther. 2013;24(12):1018-28.

Bunse CE, Borchers S, Varanasi PR, Tischer S, Figueiredo C, Immenschuh S, Kalinke U, Kohl U, Goudeva L, Maecker-Kolhoff B, Ganser A, Blasczyk R, Weissinger EM, Eiz-Vesper B. Impaired Functionality of Antiviral T Cells in G-Csf Mobilized Stem Cell Donors: Implications for the Selection of Ctl Donor. PLoS One. 2013;8(12):e77925.

Sundarasetty BS, Singh VK, Salguero G, Geffers R, Rickmann M, Macke L, Borchers S, Figueiredo C, Schambach A, Gullberg U, Provasi E, Bonini C, Ganser A, Woelfel T, Stripecke R. Lentivirus-Induced Dendritic Cells for Immunization against High-Risk Wt1(+) Acute Myeloid Leukemia. Hum Gene Ther. 2013;24(2):220-37.

Figueiredo C, Wedekind D, Muller T, Vahlsing S, Horn PA, Seltsam A, Blasczyk R. Mhc Universal Cells Survive in an Allogeneic Environment after Incompatible Transplantation. Biomed Res Int. 2013;2013:796046.

Rickmann M, Macke L, Sundarasetty BS, Stamer K, Figueiredo C, Blasczyk R, Heuser M, Krauter J, Ganser A, Stripecke R. Monitoring Dendritic Cell and Cytokine Biomarkers During Remission Prior to Relapse in Patients with Flt3-Itd Acute Myeloid Leukemia. Ann Hematol. 2013;92(8):1079-90.

Tischer S, Bunse C, Figueiredo C, Immenschuh S, Blasczyk R, Eiz-Vesper B. The New Hla-B*58:21 Allele Is Predicted to Be Functionally Similar to the B*58:01p Group of Alleles. Tissue Antigens. 2013;81(3):178-9.

Zilian E, Figueiredo C, Eiz-Vesper B, Blasczyk R, Immenschuh S. The New Hla-C Variant Hla-C*05:26 Is Likely to Be Structurally Identical to the C*05:01p Alleles. Tissue Antigens. 2013;81(3):179-80.

Figueiredo C, Blasczyk R. RNA Interference-Mediated Cell Camouflage: A Novel Approach to Prevent Rejection in Allogeneic Transplantation. Advances in Genetics Research. Volume 10. 2013 ISBN: 978-1-62417-929-7

2012

Gras C, Immenschuh S, Eiz-Vesper B, Blasczyk R, Figueiredo C. The Novel Allele Hla-B*35:167 Differs from Hla-B*35:03:01 by the Amino Acid Exchange Val152glu. Tissue Antigens. 2012;79(2):135-7.

Daenthanasanmak A, Salguero G, Borchers S, Figueiredo C, Jacobs R, Sundarasetty BS, Schneider A, Schambach A, Eiz-Vesper B, Blasczyk R, Weissinger EM, Ganser A, Stripecke R. Integrase-Defective Lentiviral Vectors Encoding Cytokines Induce Differentiation of Human Dendritic Cells and Stimulate Multivalent Immune Responses in Vitro and in Vivo. Vaccine. 2012;30(34):5118-31.

Pincha M, Sundarasetty BS, Salguero G, Gutzmer R, Garritsen H, Macke L, Schneider A, Lenz D, Figueiredo C, Blasczyk R, Ruggiero E, Schmidt M, von Kalle C, Puff C, Modlich U, von der Leyen H, Wicke DC, Ganser A, Stripecke R. Identity, Potency, in Vivo Viability, and Scaling up Production of Lentiviral Vector-Induced Dendritic Cells for Melanoma Immunotherapy. Hum Gene Ther Methods. 2012;23(1):38-55.

Wachstein J, Tischer S, Figueiredo C, Limbourg A, Falk C, Immenschuh S, Blasczyk R, Eiz-Vesper B. Hsp70 Enhances Immunosuppressive Function of Cd4(+)Cd25(+)Foxp3(+) T Regulatory Cells and Cytotoxicity in Cd4(+)Cd25(-) T Cells. PLoS One. 2012;7(12):e51747.

Schlahsa L, Immenschuh S, Eiz-Vesper B, Blasczyk R, Figueiredo C. Hla-B*08:01:08- Joining the Fold of Silent Alpha-1 Proline Mutations in Hla-B. Tissue Antigens. 2012;79(3):208-9.

Jaimes Y, Gras C, Goudeva L, Buchholz S, Eiz-Vesper B, Seltsam A, Immenschuh S, Blasczyk R, Figueiredo C. Semaphorin 7a Inhibits Platelet Production from Cd34+ Progenitor Cells. J Thromb Haemost. 2012;10(6):1100-8.

Martens J, Verboom M, Figueiredo C, Eiz-Vesper B, Blasczyk R, Immenschuh S. The New Hla Allele, Hla-a*03:57, Differs from Hla-a*03:01 by Two Amino Acids at Positions 76 and 77 in the Alpha2 Domain Affecting the Pocket F of the Peptide-Binding Groove. Tissue Antigens. 2012;79(2):131-2.

Tischer S, Kaireit T, Figueiredo C, Hiller O, Maecker-Kolhoff B, Geyeregger R, Immenschuh S, Blasczyk R, Eiz-Vesper B. Establishment of the Reversible Peptide-Major Histocompatibility Complex (Pmhc) Class I Histamer Technology: Tool for Visualization and Selection of Functionally Active Antigen-Specific Cd8(+) T Lymphocytes. Int Immunol. 2012;24(9):561-72.

Foll D, Hinrichs J, Tischer S, Battermann A, Schambach A, Figueiredo C, Immenschuh S, Blasczyk R, Eiz-Vesper B. Closing the Gap: Discrimination of the Expression Profile of Hla Questionable Alleles by a Cytokine-Induced Secretion Approach Using Hla-a*32:11q. Tissue Antigens. 2012;79(5):340-50.

2011

Salguero G, Sundarasetty BS, Borchers S, Wedekind D, Eiz-Vesper B, Velaga S, Jirmo AC, Behrens G, Warnecke G, Knofel AK, Blasczyk R, Mischak-Weissinger E, Ganser A, Stripecke R. Preconditioning Therapy with Lentiviral Vector-Programmed Dendritic Cells Accelerates the Homeostatic Expansion of Antigen-Reactive Human T Cells in Nod.Rag1-/-.Il-2rgammac-/- Mice. Hum Gene Ther. 2011;22(10):1209-24.

Bajor A, Tischer S, Figueiredo C, Wittmann M, Immenschuh S, Blasczyk R, Eiz-Vesper B. Modulatory Role of Calreticulin as Chaperokine for Dendritic Cell-Based Immunotherapy. Clin Exp Immunol. 2011;165(2):220-34.

Jaimes Y, Seltsam A, Eiz-Vesper B, Blasczyk R, Figueiredo C. Regulation of Hla Class Ii Expression Prevents Allogeneic T-Cell Responses. Tissue Antigens. 2011;77(1):36-44.

Schlahsa L, Jaimes Y, Blasczyk R, Figueiredo C. Granulocyte-Colony-Stimulatory Factor: A Strong Inhibitor of Natural Killer Cell Function. Transfusion. 2011;51(2):293-305.

2010

Jaimes Y, Figueiredo C, Blasczyk R. Silencing the Expression of Platelet Endothelial Cell Adhesion Molecule-1 Prevents Allogeneic T-Cell Cytotoxicity. Transfusion. 2010;50(9):1988-2000.

Guech-Ongey M, Verboom M, Pfeiffer RM, Schulz TF, Ndugwa CM, Owor AM, Bakaki PM, Bhatia K, Figueiredo C, Eiz-Vesper B, Blasczyk R, Mbulaiteye SM. Hla Polymorphisms and Detection of Kaposi Sarcoma-Associated Herpesvirus DNA in Saliva and Peripheral Blood among Children and Their Mothers in the Uganda Sickle Cell Anemia Kshv Study. Infect Agent Cancer. 2010;5:21.

Figueiredo C, Goudeva L, Horn PA, Eiz-Vesper B, Blasczyk R, Seltsam A. Generation of Hla-Deficient Platelets from Hematopoietic Progenitor Cells. Transfusion. 2010;50(8):1690-701.

2009

Figueiredo C, Mbulaiteye S, Ndugwa CM, Schulz T, Eiz-Vesper B. Assessment of the Amino Acid Substitution in Hla-B*5719 for Allorecognition. Tissue Antigens. 2009;73(4):376-8.

Figueiredo C, Jaimes Y, Horn PA, Blasczyk R, Eiz-Vesper B. The New Hla-Cw*0524 Allele Increase the Variability of Position 49 in Hla-C. Tissue Antigens. 2009;74(3):258-9.

Figueiredo C, Seltsam A, Blasczyk R. Permanent Silencing of Nkg2a Expression for Cell-Based Therapeutics. J Mol Med (Berl). 2009;87(2):199-210.

Hinrichs J, Figueiredo C, Hirv K, Mytilineos J, Blasczyk R, Horn PA, Eiz-Vesper B. Discrimination of Hla Null and Low Expression Alleles by Cytokine-Induced Secretion of Recombinant Soluble Hla. Mol Immunol. 2009;46(7):1451-7.

Figueiredo C, Wittmann M, Wang D, Dressel R, Seltsam A, Blasczyk R, Eiz-Vesper B. Heat Shock Protein 70 (Hsp70) Induces Cytotoxicity of T-Helper Cells. Blood. 2009;113(13):3008-16.

2007

Figueiredo C, Horn PA, Blasczyk R, Seltsam A. Regulating Mhc Expression for Cellular Therapeutics. Transfusion. 2007;47(1):18-27.

Unit 6.4 - Regenerative Immune Therapies Applied

2016

Volk V, Schneider A, Spineli LM, Grosshennig A, Stripecke R. The gender gap: discrepant human T-cell reconstitution after cord blood stem cell transplantation in humanized female and male mice. Bone Marrow Transplant. 2016;51(4):596-7.

Pinho MP, Sundarasetty BS, Bergami-Santos PC, Steponavicius-Cruz K, Ferreira AK, Stripecke R, Barbuto JA. Dendritic-tumor cell hybrids induce tumor-specific immune responses more effectively than the simple mixture of dendritic and tumor cells. Cytotherapy. 2016;18(4):570-80.

Low HZ, Ahrenstorf G, Pommerenke C, Habermann N, Schughart K, Ordonez D, Stripecke R, Wilk E, Witte T. TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads. Retrovirology. 2016;13:15.

2015

Sundarasetty BS, Chan L, Darling D, Giunti G, Farzaneh F, Schenck F, Naundorf S, Kuehlcke K, Ruggiero E, Schmidt M, von Kalle C, Rothe M, Hoon DS, Gerasch L, Figueiredo C, Koehl U, Blasczyk R, Gutzmer R, Stripecke R. Lentivirus-Induced 'Smart' Dendritic Cells: Pharmacodynamics and Gmp-Compliant Production for Immunotherapy against Trp2-Positive Melanoma. Gene Ther. 2015;22(9):707-20. Epub 2015/05/13.

Sundarasetty BS, Kloess S, Oberschmidt O, Naundorf S, Kuehlcke K, Daenthanasanmak A, Gerasch L, Figueiredo C, Blasczyk R, Ruggiero E, Fronza R, Schmidt M, von Kalle C, Rothe M, Ganser A, Koehl U, Stripecke R. Generation of Lentivirus-Induced Dendritic Cells under Gmp-Compliant Conditions for Adaptive Immune Reconstitution against Cytomegalovirus after Stem Cell Transplantation. J Transl Med. 2015;13:240. Epub 2015/07/23.

Volk V, Schneider A, Spineli LM, Grosshennig A, (1, 2) R. The Gender Gap: Discrepant human T cell reconstitution after cord blood stem cell transplantation in humanized female and male mice. Bone Marrow Transplantation, in press.

Daenthanasanmak A, Salguero G, Sundarasetty BS, Waskow C, Cosgun KN, Guzman CA, Riese P, Gerasch L, Schneider A, Ingendoh A, Messerle M, Gabaev I, Woelk B, Ruggiero E, Schmidt M, von Kalle C, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, Stripecke R. Engineered Dendritic Cells from Cord Blood and Adult Blood Accelerate Effector T Cell Immune Reconstitution against Hcmv. Mol Ther Methods Clin Dev. 2015;1:14060.

2014

Salguero G, Daenthanasanmak A, Munz C, Raykova A, Guzman CA, Riese P, Figueiredo C, Langer F, Schneider A, Macke L, Sundarasetty BS, Witte T, Ganser A, Stripecke R. Dendritic Cell-Mediated Immune Humanization of Mice: Implications for Allogeneic and Xenogeneic Stem Cell Transplantation. J Immunol. 2014;192(10):4636-47.

Tischer S, Dieks D, Sukdolak C, Bunse C, Figueiredo C, Immenschuh S, Borchers S, Stripecke R, Maecker-Kolhoff B, Blasczyk R, Eiz-Vesper B. Evaluation of Suitable Target Antigens and Immunoassays for High-Accuracy Immune Monitoring of Cytomegalovirus and Epstein-Barr Virus-Specific T Cells as Targets of Interest in Immunotherapeutic Approaches. J Immunol Methods. 2014;408:101-13.

Stripecke R. Lentivirus-Induced Dendritic Cells (Idc) for Immune-Regenerative Therapies in Cancer and Stem Cell Transplantation. Biomedicines. 2014;2(3):229.

Schlahsa L, Zhang H, Battermann A, Verboom M, Immenschuh S, Eiz-Vesper B, Stripecke R, Engelmann K, Blasczyk R, Figueiredo C. Semaphorin 3a Alters Endothelial Cell Immunogenicity by Regulating Class Ii Transactivator Activity Circuits. Transfusion. 2014;54(8):1961-70.

2013

Low HZ, Reuter S, Topperwien M, Dankenbrink N, Peest D, Kabalak G, Stripecke R, Schmidt RE, Matthias T, Witte T. Association of the Lilra3 Deletion with B-Nhl and Functional Characterization of the Immunostimulatory Molecule. PLoS One. 2013;8(12):e81360.

Lam P, Khan G, Stripecke R, Hui KM, Kasahara N, Peng KW, Guinn BA. The Innovative Evolution of Cancer Gene and Cellular Therapies. Cancer Gene Ther. 2013;20(3):141-9.

Sundarasetty BS, Singh VK, Salguero G, Geffers R, Rickmann M, Macke L, Borchers S, Figueiredo C, Schambach A, Gullberg U, Provasi E, Bonini C, Ganser A, Woelfel T, Stripecke R. Lentivirus-Induced Dendritic Cells for Immunization against High-Risk Wt1(+) Acute Myeloid Leukemia. Hum Gene Ther. 2013;24(2):220-37.

Rickmann M, Macke L, Sundarasetty BS, Stamer K, Figueiredo C, Blasczyk R, Heuser M, Krauter J, Ganser A, Stripecke R. Monitoring Dendritic Cell and Cytokine Biomarkers During Remission Prior to Relapse in Patients with Flt3-Itd Acute Myeloid Leukemia. Ann Hematol. 2013;92(8):1079-90.

Wolf S, Rudolph C, Morgan M, Busche G, Salguero G, Stripecke R, Schlegelberger B, Baum C, Modlich U. Selection for Evi1 Activation in Myelomonocytic Leukemia Induced by Hyperactive Signaling through Wild-Type Nras. Oncogene. 2013;32(25):3028-38.

2012

Pincha M, Sundarasetty BS, Salguero G, Gutzmer R, Garritsen H, Macke L, Schneider A, Lenz D, Figueiredo C, Blasczyk R, Ruggiero E, Schmidt M, von Kalle C, Puff C, Modlich U, von der Leyen H, Wicke DC, Ganser A, Stripecke R. Identity, Potency, in Vivo Viability, and Scaling up Production of Lentiviral Vector-Induced Dendritic Cells for Melanoma Immunotherapy. Hum Gene Ther Methods. 2012;23(1):38-55.

Daenthanasanmak A, Salguero G, Borchers S, Figueiredo C, Jacobs R, Sundarasetty BS, Schneider A, Schambach A, Eiz-Vesper B, Blasczyk R, Weissinger EM, Ganser A, Stripecke R. Integrase-Defective Lentiviral Vectors Encoding Cytokines Induce Differentiation of Human Dendritic Cells and Stimulate Multivalent Immune Responses in Vitro and in Vivo. Vaccine. 2012;30(34):5118-31.

2011

Rickmann M, Krauter J, Stamer K, Heuser M, Salguero G, Mischak-Weissinger E, Ganser A, Stripecke R. Elevated Frequencies of Leukemic Myeloid and Plasmacytoid Dendritic Cells in Acute Myeloid Leukemia with the Flt3 Internal Tandem Duplication. Ann Hematol. 2011;90(9):1047-58.

Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Busche G, Ganser A, Stripecke R. Lentiviral Vectors for Induction of Self-Differentiation and Conditional Ablation of Dendritic Cells. Gene Ther. 2011;18(8):750-64.

Salguero G, Sundarasetty BS, Borchers S, Wedekind D, Eiz-Vesper B, Velaga S, Jirmo AC, Behrens G, Warnecke G, Knofel AK, Blasczyk R, Mischak-Weissinger E, Ganser A, Stripecke R. Preconditioning Therapy with Lentiviral Vector-Programmed Dendritic Cells Accelerates the Homeostatic Expansion of Antigen-Reactive Human T Cells in Nod.Rag1-/-.Il-2rgammac-/- Mice. Hum Gene Ther. 2011;22(10):1209-24.

2010

Pincha M, Sundarasetty BS, Stripecke R. Lentiviral Vectors for Immunization: An Inflammatory Field. Expert Rev Vaccines. 2010;9(3):309-21.

Jirmo AC, Koya RC, Sundarasetty BS, Pincha M, Yu GY, Lai M, Bakshi R, Schlaphoff V, Grabowski J, Behrens G, Wedemeyer H, Stripecke R. Monocytes Transduced with Lentiviral Vectors Expressing Hepatitis C Virus Non-Structural Proteins and Differentiated into Dendritic Cells Stimulate Multi-Antigenic Cd8(+) T Cell Responses. Vaccine. 2010;28(4):922-33.

2009

Stripecke R. Lentiviral Vector-Mediated Genetic Programming of Mouse and Human Dendritic Cells. Methods Mol Biol. 2009;506:139-58.

2008

Kochling J, Prada J, Bahrami M, Stripecke R, Seeger K, Henze G, Wittig B, Schmidt M. Anti-Tumor Effect of DNA-Based Vaccination and Dslim Immunomodulatory Molecules in Mice with Ph+ Acute Lymphoblastic Leukaemia. Vaccine. 2008;26(36):4669-75. Epub 2008/07/22.

Sarafian T, Montes C, Harui A, Beedanagari SR, Kiertscher S, Stripecke R, Hossepian D, Kitchen C, Kern R, Belperio J, Roth MD. Clarifying Cb2 Receptor-Dependent and Independent Effects of Thc on Human Lung Epithelial Cells. Toxicol Appl Pharmacol. 2008;231(3):282-90.

Cheng JC, Kinjo K, Judelson DR, Chang J, Wu WS, Schmid I, Shankar DB, Kasahara N, Stripecke R, Bhatia R, Landaw EM, Sakamoto KM. Creb Is a Critical Regulator of Normal Hematopoiesis and Leukemogenesis. Blood. 2008;111(3):1182-92. Epub 2007/11/03.

2007

Koya RC, Kimura T, Ribas A, Rozengurt N, Lawson GW, Faure-Kumar E, Wang HJ, Herschman H, Kasahara N, Stripecke R. Lentiviral Vector-Mediated Autonomous Differentiation of Mouse Bone Marrow Cells into Immunologically Potent Dendritic Cell Vaccines. Mol Ther. 2007;15(5):971-80.

Kimura T, Koya RC, Anselmi L, Sternini C, Wang HJ, Comin-Anduix B, Prins RM, Faure-Kumar E, Rozengurt N, Cui Y, Kasahara N, Stripecke R. Lentiviral Vectors with Cmv or Mhcii Promoters Administered in Vivo: Immune Reactivity Versus Persistence of Expression. Mol Ther. 2007;15(7):1390-9.

2004

Koya RC, Weber JS, Kasahara N, Lau R, Villacres MC, Levine AM, Stripecke R. Making Dendritic Cells from the inside Out: Lentiviral Vector-Mediated Gene Delivery of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin 4 into Cd14+ Monocytes Generates Dendritic Cells in Vitro. Hum Gene Ther. 2004;15(8):733-48.

Unit 6.5 - Engineered Antigen-presenting Cells and Artificial Lymph Nodes

2015

Hoffmann C, Hentrich M, Gillor D, Behrens G, Jensen B, Stoehr A, Esser S, van Lunzen J, Krznaric I, Muller M, Oette M, Hensel M, Thoden J, Fatkenheuer G, Wyen C. Hodgkin Lymphoma Is as Common as Non-Hodgkin Lymphoma in Hiv-Positive Patients with Sustained Viral Suppression and Limited Immune Deficiency: A Prospective Cohort Study. HIV Med. 2015;16(4):261-4. Epub 2014/09/25.

Ryom L, Boesecke C, Gisler V, Manzardo C, Rockstroh JK, Puoti M, Furrer H, Miro JM, Gatell JM, Pozniak A, Behrens G, Battegay M, Lundgren JD, Board EG. Essentials from the 2015 European Aids Clinical Society (Eacs) Guidelines for the Treatment of Adult Hiv-Positive Persons. HIV Med. 2015.

2014

Tabeling C, Scheer H, Schonrock SM, Runge F, Gutbier B, Lienau J, Hamelmann E, Opitz B, Suttorp N, Mayer K, Behrens GM, Tschernig T, Witzenrath M. Nucleotide Oligomerization Domain 1 Ligation Suppressed Murine Allergen-Specific T-Cell Proliferation and Airway Hyperresponsiveness. Am J Respir Cell Mol Biol. 2014;50(5):903-11.

Stankov MV, El Khatib M, Kumar Thakur B, Heitmann K, Panayotova-Dimitrova D, Schoening J, Bourquin JP, Schweitzer N, Leverkus M, Welte K, Reinhardt D, Li Z, Orkin SH, Behrens GM, Klusmann JH. Histone Deacetylase Inhibitors Induce Apoptosis in Myeloid Leukemia by Suppressing Autophagy. Leukemia. 2014;28(3):577-88.

Lu I, Eberhard J, Ahmad F, Bhatnagar N, Behrens G, Jacobs R, Schmidt RE, Meyer-Olson D. Elevated Cd57 and Cd95 Expressions Are Associated with Lower Numbers of Cd4(+) Recent Thymic Emigrants in Hiv-1 Infected Immune Responders Following Antiretroviral Treatment. Immunol Lett. 2014;158(1-2):1-6.

Klose J, Stankov MV, Kleine M, Ramackers W, Panayotova-Dimitrova D, Jager MD, Klempnauer J, Winkler M, Bektas H, Behrens GM, Vondran FW. Inhibition of Autophagic Flux by Salinomycin Results in Anti-Cancer Effect in Hepatocellular Carcinoma Cells. PLoS One. 2014;9(5):e95970.

2013

Stankov MV, Panayotova-Dimitrova D, Leverkus M, Schmidt RE, Behrens GM. Thymidine Analogues Suppress Autophagy and Adipogenesis in Cultured Adipocytes. Antimicrob Agents Chemother. 2013;57(1):543-51.

Solomon Tsegaye T, Gnirss K, Rahe-Meyer N, Kiene M, Kramer-Kuhl A, Behrens G, Munch J, Pohlmann S. Platelet Activation Suppresses Hiv-1 Infection of T Cells. Retrovirology. 2013;10:48.

Rollenhagen M, Buettner FF, Reismann M, Jirmo AC, Grove M, Behrens GM, Gerardy-Schahn R, Hanisch FG, Muhlenhoff M. Polysialic Acid on Neuropilin-2 Is Exclusively Synthesized by the Polysialyltransferase St8siaiv and Attached to Mucin-Type O-Glycans Located between the B2 and C Domain. J Biol Chem. 2013;288(32):22880-92.

Busche A, Jirmo AC, Welten SP, Zischke J, Noack J, Constabel H, Gatzke AK, Keyser KA, Arens R, Behrens GM, Messerle M. Priming of Cd8+ T Cells against Cytomegalovirus-Encoded Antigens Is Dominated by Cross-Presentation. J Immunol. 2013;190(6):2767-77.

2012

Stankov MV, Panayotova-Dimitrova D, Leverkus M, Vondran FW, Bauerfeind R, Binz A, Behrens GM. Autophagy Inhibition Due to Thymidine Analogues as Novel Mechanism Leading to Hepatocyte Dysfunction and Lipid Accumulation. AIDS. 2012;26(16):1995-2006.

Krishnaswamy JK, Jirmo AC, Baru AM, Ebensen T, Guzman CA, Sparwasser T, Behrens GM. Toll-Like Receptor-2 Agonist-Allergen Coupling Efficiently Redirects Th2 Cell Responses and Inhibits Allergic Airway Eosinophilia. Am J Respir Cell Mol Biol. 2012;47(6):852-63.

2011

Kuhl A, Hoffmann M, Muller MA, Munster VJ, Gnirss K, Kiene M, Tsegaye TS, Behrens G, Herrler G, Feldmann H, Drosten C, Pohlmann S. Comparative Analysis of Ebola Virus Glycoprotein Interactions with Human and Bat Cells. J Infect Dis. 2011;204 Suppl 3:S840-9.

Kuhl A, Banning C, Marzi A, Votteler J, Steffen I, Bertram S, Glowacka I, Konrad A, Sturzl M, Guo JT, Schubert U, Feldmann H, Behrens G, Schindler M, Pohlmann S. The Ebola Virus Glycoprotein and Hiv-1 Vpu Employ Different Strategies to Counteract the Antiviral Factor Tetherin. J Infect Dis. 2011;204 Suppl 3:S850-60.

Baru AM, Krishnaswamy JK, Rathinasamy A, Scherr M, Eder M, Behrens GM. Dendritic Cells Derived from Hoxb4-Immortalized Hematopoietic Bone Marrow Cells. Exp Biol Med (Maywood). 2011;236(11):1291-7.

2009

Jirmo AC, Nagel CH, Bohnen C, Sodeik B, Behrens GM. Contribution of Direct and Cross-Presentation to Ctl Immunity against Herpes Simplex Virus 1. J Immunol. 2009;182(1):283-92.

Constabel H, Stankov MV, Hartwig C, Tschernig T, Behrens GM. Impaired Lung Dendritic Cell Migration and T Cell Stimulation Induced by Immunostimulatory Oligonucleotides Contribute to Reduced Allergic Airway Inflammation. J Immunol. 2009;183(5):3443-53.

2008

Stankov MV, Schmidt RE, Behrens GM, German Competence Network HA. Zidovudine Impairs Adipogenic Differentiation through Inhibition of Clonal Expansion. Antimicrob Agents Chemother. 2008;52(8):2882-9.

Unit 6.6 - New Regulatory Mechanisms of Myelopoiesis

2015

Makaryan V, Zeidler C, Bolyard AA, Skokowa J, Rodger E, Kelley ML, Boxer LA, Bonilla MA, Newburger PE, Shimamura A, Zhu B, Rosenberg PS, Link DC, Welte K, Dale DC. The Diversity of Mutations and Clinical Outcomes for Elane-Associated Neutropenia. Curr Opin Hematol. 2015;22(1):3-11.

2014

Skokowa J, Steinemann D, Katsman-Kuipers JE, Zeidler C, Klimenkova O, Klimiankou M, Unalan M, Kandabarau S, Makaryan V, Beekman R, Behrens K, Stocking C, Obenauer J, Schnittger S, Kohlmann A, Valkhof MG, Hoogenboezem R, Gohring G, Reinhardt D, Schlegelberger B, Stanulla M, Vandenberghe P, Donadieu J, Zwaan CM, Touw IP, van den Heuvel-Eibrink MM, Dale DC, Welte K. Cooperativity of Runx1 and Csf3r Mutations in Severe Congenital Neutropenia: A Unique Pathway in Myeloid Leukemogenesis. Blood. 2014;123(14):2229-37.

Makaryan V, Rosenthal EA, Bolyard AA, Kelley ML, Below JE, Bamshad MJ, Bofferding KM, Smith JD, Buckingham K, Boxer LA, Skokowa J, Welte K, Nickerson DA, Jarvik GP, Dale DC, Genomics UWCfM. Tcirg1-Associated Congenital Neutropenia. Hum Mutat. 2014;35(7):824-7.

Klimenkova O, Ellerbeck W, Klimiankou M, Unalan M, Kandabarau S, Gigina A, Hussein K, Zeidler C, Welte K, Skokowa J. A Lack of Secretory Leukocyte Protease Inhibitor (Slpi) Causes Defects in Granulocytic Differentiation. Blood. 2014;123(8):1239-49.

Hennig C, Ilginus C, Boztug K, Skokowa J, Marodi L, Szaflarska A, Sass M, Pignata C, Kilic SS, Caragol I, Baumann U, Klein C, Welte K, Hansen G. High-Content Cytometry and Transcriptomic Biomarker Profiling of Human B-Cell Activation. J Allergy Clin Immunol. 2014;133(1):172-80 e1-10.

Gupta K, Kuznetsova I, Klimenkova O, Klimiankou M, Meyer J, Moore MA, Zeidler C, Welte K, Skokowa J. Bortezomib Inhibits Stat5-Dependent Degradation of Lef-1, Inducing Granulocytic Differentiation in Congenital Neutropenia Cd34(+) Cells. Blood. 2014;123(16):2550-61. Epub 2014/01/08.

2013

Skokowa J, Welte K. Defective G-Csfr Signaling Pathways in Congenital Neutropenia. Hematol Oncol Clin North Am. 2013;27(1):75-88, viii.

2012

Zeidler L, Zimmermann M, Moricke A, Meissner B, Bartels D, Tschan C, Schrauder A, Cario G, Goudeva L, Jager S, Ratei R, Ludwig WD, Teigler-Schlegel A, Skokowa J, Koehler R, Bartram CR, Riehm H, Schrappe M, Welte K, Stanulla M. Low Platelet Counts after Induction Therapy for Childhood Acute Lymphoblastic Leukemia Are Strongly Associated with Poor Early Response to Treatment as Measured by Minimal Residual Disease and Are Prognostic for Treatment Outcome. Haematologica. 2012;97(3):402-9.

Thakur BK, Lippka Y, Dittrich T, Chandra P, Skokowa J, Welte K. Nampt Pathway Is Involved in the Foxo3a-Mediated Regulation of Gadd45a Expression. Biochem Biophys Res Commun. 2012;420(4):714-20.

Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K. Interactions among Hcls1, Hax1 and Lef-1 Proteins Are Essential for G-Csf-Triggered Granulopoiesis. Nat Med. 2012;18(10):1550-9.

Dan L, Klimenkova O, Klimiankou M, Klusman JH, van den Heuvel-Eibrink MM, Reinhardt D, Welte K, Skokowa J. The Role of Sirtuin 2 Activation by Nicotinamide Phosphoribosyltransferase in the Aberrant Proliferation and Survival of Myeloid Leukemia Cells. Haematologica. 2012;97(4):551-9.

2009

Skokowa J, Lan D, Thakur BK, Wang F, Gupta K, Cario G, Brechlin AM, Schambach A, Hinrichsen L, Meyer G, Gaestel M, Stanulla M, Tong Q, Welte K. Nampt Is Essential for the G-Csf-Induced Myeloid Differentiation Via a Nad(+)-Sirtuin-1-Dependent Pathway. Nat Med. 2009;15(2):151-8.

Skokowa J, Fobiwe JP, Dan L, Thakur BK, Welte K. Neutrophil Elastase Is Severely Down-Regulated in Severe Congenital Neutropenia Independent of Ela2 or Hax1 Mutations but Dependent on Lef-1. Blood. 2009;114(14):3044-51.

2006

Skokowa J, Cario G, Uenalan M, Schambach A, Germeshausen M, Battmer K, Zeidler C, Lehmann U, Eder M, Baum C, Grosschedl R, Stanulla M, Scherr M, Welte K. Lef-1 Is Crucial for Neutrophil Granulocytopoiesis and Its Expression Is Severely Reduced in Congenital Neutropenia. Nat Med. 2006;12(10):1191-7.

Unit 6.7 - Molecular Control of Granulocytic Differentiation

2015

Cahu X, Labopin M, GiebelS, Aljurf M, Kyrcz-Krzemien M, Socié G, Eder M, Bonifazi F, Bunjes D, Vigouroux S, Michallet M, Stelljes M, Zuckerman T, Finke J, Passweg J, Yakoub-Agha I, Niederwieser D, Sucak G, Sengeløv H, Polge E, Nagler A, Esteve J and Mohty M. Impact of conditioning with total body irradiation in adult patients with T-cell acute lymphoblastic leukemia who receive a myeloablative allogeneic stem cell transplantation: a report from the acute leukemia working party of EBMT. Bone Marrow Transplant, in press.

Thol F, Scherr M, Kirchner A, Shahswar R, Battmer K, Kade S, Chaturvedi A, Koenecke C, Stadler M, Platzbecker U, Thiede C, Schroeder T, Kobbe G, Bug G, Ottmann O, Hofmann WK, Kroger N, Fiedler W, Schlenk R, Dohner K, Dohner H, Krauter J, Eder M, Ganser A, Heuser M. Clinical and Functional Implications of Microrna Mutations in a Cohort of 935 Patients with Myelodysplastic Syndromes and Acute Myeloid Leukemia. Haematologica. 2015;100(4):e122-4.

Stahlhut M, Schwarzer A, Eder M, Yang M, Li Z, Morgan M, Schambach A, Kustikova OS. Lentiviral Vector System for Coordinated Constitutive and Drug Controlled Tetracycline-Regulated Gene Co-Expression. Biomaterials. 2015;63:189-201.

Ding J, Dirks WG, Ehrentraut S, Geffers R, MacLeod RA, Nagel S, Pommerenke C, Romani J, Scherr M, Vaas LA, Zaborski M, Drexler HG, Quentmeier H. Bcl6--Regulated by Ahr/Arnt and Wild-Type Mef2b--Drives Expression of Germinal Center Markers Mybl1 and Lmo2. Haematologica. 2015;100(6):801-9. Epub 2015/03/15.

2014

Weissinger EM, Metzger J, Dobbelstein C, Wolff D, Schleuning M, Kuzmina Z, Greinix H, Dickinson AM, Mullen W, Kreipe H, Hamwi I, Morgan M, Krons A, Tchebotarenko I, Ihlenburg-Schwarz D, Dammann E, Collin M, Ehrlich S, Diedrich H, Stadler M, Eder M, Holler E, Mischak H, Krauter J, Ganser A. Proteomic Peptide Profiling for Preemptive Diagnosis of Acute Graft-Versus-Host Disease after Allogeneic Stem Cell Transplantation. Leukemia. 2014;28(4):842-52.

Vukadinovic-Nikolic Z, Andree B, Dorfman SE, Pflaum M, Horvath T, Lux M, Venturini L, Bar A, Kensah G, Lara AR, Tudorache I, Cebotari S, Hilfiker-Kleiner D, Haverich A, Hilfiker A. Generation of Bioartificial Heart Tissue by Combining a Three-Dimensional Gel-Based Cardiac Construct with Decellularized Small Intestinal Submucosa. Tissue Eng Part A. 2014;20(3-4):799-809.

Scherr M, Elder A, Battmer K, Barzan D, Bomken S, Ricke-Hoch M, Schroder A, Venturini L, Blair HJ, Vormoor J, Ottmann O, Ganser A, Pich A, Hilfiker-Kleiner D, Heidenreich O, Eder M. Differential Expression of Mir-17~92 Identifies Bcl2 as a Therapeutic Target in Bcr-Abl-Positive B-Lineage Acute Lymphoblastic Leukemia. Leukemia. 2014;28(3):554-65.

Schaller-Schonitz M, Barzan D, Williamson AJ, Griffiths JR, Dallmann I, Battmer K, Ganser A, Whetton AD, Scherr M, Eder M. Bcr-Abl Affects Stat5a and Stat5b Differentially. PLoS One. 2014;9(5):e97243.

Ricke-Hoch M, Bultmann I, Stapel B, Condorelli G, Rinas U, Sliwa K, Scherr M, Hilfiker-Kleiner D. Opposing Roles of Akt and Stat3 in the Protection of the Maternal Heart from Peripartum Stress. Cardiovasc Res. 2014;101(4):587-96.

Panagiota V, Thol F, Markus B, Fehse B, Alchalby H, Badbaran A, Lehmann U, Koenecke C, Shahswar R, Chaturvedi A, Stadler M, Eder M, Gohring G, Koenigsmann M, Kloos A, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kreipe HH, Ganser A, Kroger N, Heuser M. Prognostic Effect of Calreticulin Mutations in Patients with Myelofibrosis after Allogeneic Hematopoietic Stem Cell Transplantation. Leukemia. 2014;28(7):1552-5.

Koenecke C, Pischke S, Beutel G, Ritter U, Ganser A, Wedemeyer H, Eder M. Hepatitis E Virus Infection in a Hematopoietic Stem Cell Donor. Bone Marrow Transplant. 2014;49(1):159-60.

Heuser M, Schlarmann C, Dobbernack V, Panagiota V, Wiehlmann L, Walter C, Beier F, Ziegler P, Yun H, Kade S, Kirchner A, Huang L, Koenecke C, Eder M, Brummendorf TH, Dugas M, Ganser A, Thol F. Genetic Characterization of Acquired Aplastic Anemia by Targeted Sequencing. Haematologica. 2014;99(9):e165-7.

Heuser M, Panagiota V, Koenecke C, Fehse B, Alchalby H, Badbaran A, Shahswar R, Stadler M, Eder M, Gohring G, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kroeger N, Ganser A, Thol F. Low Frequency of Calreticulin Mutations in Mds Patients. Leukemia. 2014;28(9):1933-4.

Andree B, Bela K, Horvath T, Lux M, Ramm R, Venturini L, Ciubotaru A, Zweigerdt R, Haverich A, Hilfiker A. Successful Re-Endothelialization of a Perfusable Biological Vascularized Matrix (Biovam) for the Generation of 3d Artificial Cardiac Tissue. Basic Res Cardiol. 2014;109(6):441.

2013

Shehadeh LA, Sharma S, Pessanha M, Wei JQ, Liu J, Yuan H, Rodrigues CO, Scherr M, Tsinoremas NF, Bishopric NH. Microrna-20a Constrains P300-Driven Myocardial Angiogenic Transcription by Direct Targeting of P300. PLoS One. 2013;8(11):e79133.

Quentmeier H, Amini RM, Berglund M, Dirks WG, Ehrentraut S, Geffers R, Macleod RA, Nagel S, Romani J, Scherr M, Zaborski M, Drexler HG. U-2932: Two Clones in One Cell Line, a Tool for the Study of Clonal Evolution. Leukemia. 2013;27(5):1155-64.

Halkein J, Tabruyn SP, Ricke-Hoch M, Haghikia A, Nguyen NQ, Scherr M, Castermans K, Malvaux L, Lambert V, Thiry M, Sliwa K, Noel A, Martial JA, Hilfiker-Kleiner D, Struman I. Microrna-146a Is a Therapeutic Target and Biomarker for Peripartum Cardiomyopathy. J Clin Invest. 2013;123(5):2143-54.

Elschami M, Scherr M, Philippens B, Gerardy-Schahn R. Reduction of Stat3 Expression Induces Mitochondrial Dysfunction and Autophagy in Cardiac Hl-1 Cells. Eur J Cell Biol. 2013;92(1):21-9.

Ehrentraut S, Nagel S, Scherr ME, Schneider B, Quentmeier H, Geffers R, Kaufmann M, Meyer C, Prochorec-Sobieszek M, Ketterling RP, Knudson RA, Feldman AL, Kadin ME, Drexler HG, MacLeod RA. T(8;9)(P22;P24)/Pcm1-Jak2 Activates Socs2 and Socs3 Via Stat5. PLoS One. 2013;8(1):e53767.

Dobbelstein C, Ahn KW, Haagenson M, Hale GA, van Rood JJ, Miklos D, Waller EK, Spellman SR, Fernandez-Vina M, Ganser A, Aljurf M, Bornhaeuser M, Gupta V, Marino SR, Pollack MS, Reddy V, Eder M, Lee SJ. Birth Order and Transplantation Outcome in Hla-Identical Sibling Stem Cell Transplantation: An Analysis on Behalf of the Center for International Blood and Marrow Transplantation. Biol Blood Marrow Transplant. 2013;19(5):741-5.

2012

Borchers S, Bremm M, Lehrnbecher T, Dammann E, Pabst B, Wolk B, Esser R, Yildiz M, Eder M, Stadler M, Bader P, Martin H, Jarisch A, Schneider G, Klingebiel T, Ganser A, Weissinger EM, Koehl U. Sequential Anti-Cytomegalovirus Response Monitoring May Allow Prediction of Cytomegalovirus Reactivation after Allogeneic Stem Cell Transplantation. PLoS One. 2012;7(12):e50248.

Barkam C, Kamal H, Dammann E, Diedrich H, Buchholz S, Eder M, Krauter J, Ganser A, Stadler M. Improving Safety of Preemptive Therapy with Oral Valganciclovir for Cytomegalovirus Infection after Allogeneic Hematopoietic Stem Cell Transplantation. Bone Marrow Res. 2012;2012:874601.

2011

Surdziel E, Cabanski M, Dallmann I, Lyszkiewicz M, Krueger A, Ganser A, Scherr M, Eder M. Enforced Expression of Mir-125b Affects Myelopoiesis by Targeting Multiple Signaling Pathways. Blood. 2011;117(16):4338-48.

2010

Surdziel E, Eder M, Scherr M. Lentivirus-Mediated Antagomir Expression. Methods Mol Biol. 2010;667:237-48.

Unit 7.1 - Functionalized Polymers and Regenerative Agents

2017

Jara-Avaca M, Kempf H, Ruckert M, Robles-Diaz D, Franke A, de la Roche J, Fischer M, Malan D, Sasse P, Solodenko W, Drager G, Kirschning A, Martin U, Zweigerdt R. EBIO Does Not Induce Cardiomyogenesis in Human Pluripotent Stem Cells but Modulates Cardiac Subtype Enrichment by Lineage-Selective Survival. Stem cell reports. 2017.

2016

Wang LL, Balakrishnan A, Bigall NC, Candito D, Miethe JF, Seidel K, Xie Y, Ott M, Kirschning A. A Bio-Chemosynthetic Approach to Superparamagnetic Iron Oxide-Ansamitocin Conjugates for Use in Magnetic Drug Targeting. Chemistry. 2016.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature communications. 2016;7:13602.

Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T. Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Cell Biol Int. 2016;40(5):534-48.

Dibbert N, Krause A, Rios-Camacho JC, Gruh I, Kirschning A, Drager G. A Synthetic Toolbox for the In Situ Formation of Functionalized Homo- and Heteropolysaccharide-Based Hydrogel Libraries. Chemistry. 2016;22(52):18777-86.

2015

Williams S, Neumann A, Bremer I, Su Y, Drager G, Kasper C, Behrens P. Nanoporous Silica Nanoparticles as Biomaterials: Evaluation of Different Strategies for the Functionalization with Polysialic Acid by Step-by-Step Cytocompatibility Testing. J Mater Sci Mater Med. 2015;26(3):125. Epub 2015/02/19.

Hermane J, Bułyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter J-G, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A. New, Non-Quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90. ChemBioChem. 2015;16(2):302-11.

Stumpp N, Premnath P, Schmidt T, Ammermann J, Drager G, Reck M, Jansen R, Stiesch M, Wagner-Dobler I, Kirschning A. Synthesis of New Carolacton Derivatives and Their Activity against Biofilms of Oral Bacteria. Org Biomol Chem. 2015;13(20):5765-74. Epub 2015/04/23.

2014

Mikhova, B., Janevska, V., Stambolizska, B., Draeger, G., Popovski, E. Synthesis and structure of some novel dicoumarinamines. Bulgarian Chemical Communications. 2014; 46:135-140.

Mancuso L, Knobloch T, Buchholz J, Hartwig J, Moller L, Seidel K, Collisi W, Sasse F, Kirschning A. Preparation of Thermocleavable Conjugates Based on Ansamitocin and Superparamagnetic Nanostructured Particles by a Chemobiosynthetic Approach. Chemistry. 2014;20(52):17541-51.

Jirawutthiwongchai J, Draeger G, Chirachanchai S. Rapid Hybridization of Chitosan-Gold-Antibodies Via Metal-Free Click in Water-Based Systems: A Model Approach for Naked-Eye Detectable Antigen Sensors. Macromol Rapid Commun. 2014;35(13):1204-10.

Jashari A, Imeri F, Ballazhi L, Shabani A, Mikhova B, Drager G, Popovski E, Huwiler A. Synthesis and Cellular Characterization of Novel Isoxazolo- and Thiazolohydrazinylidene-Chroman-2,4-Diones on Cancer and Non-Cancer Cell Growth and Death. Bioorg Med Chem. 2014;22(9):2655-61.

2013

Su Y, Paleček J, Kirschning A, Dräger G. Copper Mediated and Copper Free “Click” Decoration of Polysialic Acid for Rgd-Modification and Hydrogel Formation. Macromolecular Symposia. 2013;334(1):82-91.

Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U. Keratinocyte Growth Factor and Dexamethasone Plus Elevated Camp Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type Ii Cells. Tissue Eng Part A. 2013;19(7-8):938-51.

Moller L, Hess C, Palecek J, Su Y, Haverich A, Kirschning A, Drager G. Towards a Biocompatible Artificial Lung: Covalent Functionalization of Poly(4-Methylpent-1-Ene) (Tpx) with Crgd Pentapeptide. Beilstein J Org Chem. 2013;9:270-7.

Kensah G, Roa Lara A, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Drager G, Ochs M, Haverich A, Gruh I, Martin U. Murine and Human Pluripotent Stem Cell-Derived Cardiac Bodies Form Contractile Myocardial Tissue in Vitro. Eur Heart J. 2013;34(15):1134-46.

Jirawutthiwongchai J, Krause A, Draeger G, Chirachanchai S. Chitosan-Oxanorbornadiene: A Convenient Chitosan Derivative for Click Chemistry without Metal Catalyst Problem. ACS Macro Letters. 2013;2(3):177-80.

Dahlmann J, Krause A, Moller L, Kensah G, Mowes M, Diekmann A, Martin U, Kirschning A, Gruh I, Drager G. Fully Defined in Situ Cross-Linkable Alginate and Hyaluronic Acid Hydrogels for Myocardial Tissue Engineering. Biomaterials. 2013;34(4):940-51.

Dahlmann J, Kensah G, Kempf H, Skvorc D, Gawol A, Elliott DA, Dräger G, Zweigerdt R, Martin U, Gruh I. The Use of Agarose Microwells for Scalable Embryoid Body Formation and Cardiac Differentiation of Human and Murine Pluripotent Stem Cells. Biomaterials. 2013;34(10):2463-71.

2012

Krause A, Kirschning A, Drager G. Bioorthogonal Metal-Free Click-Ligation of Crgd-Pentapeptide to Alginate. Org Biomol Chem. 2012;10(29):5547-53.

Knobloch T, Drager G, Collisi W, Sasse F, Kirschning A. Unprecedented Deoxygenation at C-7 of the Ansamitocin Core During Mutasynthetic Biotransformations. Beilstein J Org Chem. 2012;8:861-9.

2011

Palecek J, Zweigerdt R, Olmer R, Martin U, Kirschning A, Drager G. A Practical Synthesis of Rho-Kinase Inhibitor Y-27632 and Fluoro Derivatives and Their Evaluation in Human Pluripotent Stem Cells. Org Biomol Chem. 2011;9(15):5503-10.

Paleček J, Dräger G, Kirschning A. A Practical Large-Scale Synthesis of Cyclic Rgd Pentapeptides Suitable for Further Functionalization through ‘Click’ Chemistry. Synthesis. 2011;2011(04):653-61. Epub 11.01.2011.

Ovsianikov A, Deiwick A, Van Vlierberghe S, Dubruel P, Moller L, Drager G, Chichkov B. Laser Fabrication of Three-Dimensional Cad Scaffolds from Photosensitive Gelatin for Applications in Tissue Engineering. Biomacromolecules. 2011;12(4):851-8.

Möller L, Krause A, Bartsch I, Kirschning A, Witte F, Dräger G. Preparation and in Vivo Imaging of Lucifer Yellow Tagged Hydrogels. Macromolecular Symposia. 2011;309-310(1):222-8.

Dräger G, Krause A, Möller L, Dumitriu S. Carbohydrates. Handbook of Biodegradable Polymers: Wiley-VCH Verlag GmbH & Co. KGaA; 2011. p. 155-93.

2010

Su Y, Kasper C, Kirschning A, Drager G, Berski S. Synthesis of New Polysialic Acid Derivatives. Macromol Biosci. 2010;10(9):1028-33.

Olmer R, Haase A, Merkert S, Cui W, Palecek J, Ran C, Kirschning A, Scheper T, Glage S, Miller K, Curnow EC, Hayes ES, Martin U. Long Term Expansion of Undifferentiated Human Ips and Es Cells in Suspension Culture Using a Defined Medium. Stem Cell Res. 2010;5(1):51-64.

Harmrolfs K, Brunjes M, Drager G, Floss HG, Sasse F, Taft F, Kirschning A. Cyclization of Synthetic Seco-Proansamitocins to Ansamitocin Macrolactams by Actinosynnema Pretiosum as Biocatalyst. Chembiochem. 2010;11(18):2517-20.

Haastert-Talini K, Schaper-Rinkel J, Schmitte R, Bastian R, Muhlenhoff M, Schwarzer D, Draeger G, Su Y, Scheper T, Gerardy-Schahn R, Grothe C. In Vivo Evaluation of Polysialic Acid as Part of Tissue-Engineered Nerve Transplants. Tissue Eng Part A. 2010;16(10):3085-98. Epub 2010/05/22.

Assmann U, Szentivanyi A, Stark Y, Scheper T, Berski S, Drager G, Schuster RH. Fiber Scaffolds of Polysialic Acid Via Electrospinning for Peripheral Nerve Regeneration. J Mater Sci Mater Med. 2010;21(7):2115-24.

2008

Hartlieb S, Gunzel A, Gerardy-Schahn R, Munster-Kuhnel AK, Kirschning A, Drager G. Chemoenzymatic Synthesis of Cmp-N-Acetyl-7-Fluoro-7-Deoxy-Neuraminic Acid. Carbohydr Res. 2008;343(12):2075-82.

Haile Y, Berski S, Drager G, Nobre A, Stummeyer K, Gerardy-Schahn R, Grothe C. The Effect of Modified Polysialic Acid Based Hydrogels on the Adhesion and Viability of Primary Neurons and Glial Cells. Biomaterials. 2008;29(12):1880-91.

Berski S, van Bergeijk J, Schwarzer D, Stark Y, Kasper C, Scheper T, Grothe C, Gerardy-Schahn R, Kirschning A, Drager G. Synthesis and Biological Evaluation of a Polysialic Acid-Based Hydrogel as Enzymatically Degradable Scaffold Material for Tissue Engineering. Biomacromolecules. 2008;9(9):2353-9.

2007

Haile Y, Haastert K, Cesnulevicius K, Stummeyer K, Timmer M, Berski S, Drager G, Gerardy-Schahn R, Grothe C. Culturing of Glial and Neuronal Cells on Polysialic Acid. Biomaterials. 2007;28(6):1163-73.

Drager G, Kiss C, Kunz U, Kirschning A. Enzyme-Purification and Catalytic Transformations in a Microstructured Passflow Reactor Using a New Tyrosine-Based Ni-Nta Linker System Attached to a Polyvinylpyrrolidinone-Based Matrix. Org Biomol Chem. 2007;5(22):3657-64.

Dräger G, Jeske F, Kunst E, Lopez EG, Sanchez HV, Tsichritzis F, Kirschning A, Jakupovic J. Tonantzitlolone and Other Diterpenes from Stillingia Sanguinolenta. European Journal of Organic Chemistry. 2007;2007(36):6128-.

Bruns S, Stark Y, Roker S, Wieland M, Drager G, Kirschning A, Stahl F, Kasper C, Scheper T. Collagen Biomaterial Doped with Colominic Acid for Cell Culture Applications with Regard to Peripheral Nerve Repair. J Biotechnol. 2007;131(3):335-45.

Unit 7.2 - Nanoengineering

2017

Shpichka AI, Koroleva AV, Deiwick A, Timashev PS, Semenova EF, Moiseeva IY, Konoplyannikov MA, Chichkov BN. Evaluation of the vasculogenic potential of hydrogels based on modified fibrin. Cell and Tissue Biology. 2017;11(1):81-7.

Koch L, Deiwick A, Chichkov B. 16 - Laser additive printing of cells A2 - Brandt, Milan.  Laser Additive Manufacturing: Woodhead Publishing; 2017. p. 421-37.

Koch L, Brandt O, Deiwick A, Chichkov B. Laser assisted bioprinting at different wavelengths and pulse durations with a metal dynamic release layer: A parametric study. 2017. 2017;3(1).

2016

Taidi B, Lebernede G, Koch L, Perre P, Chichkov B. Colony development of laser printed eukaryotic (yeast and microalga) microorganisms in co-culture. 2016. 2016;2(2).

Koroleva A, Deiwick A, Nguyen A, Narayan R, Shpichka A, Kufelt O, Kiyan R, Bagratashvili V, Timashev P, Scheper T, Chichkov B. Hydrogel-based microfluidics for vascular tissue engineering. BioNanoMaterials2016. p. 19.

Koch L, Deiwick A, Chichkov B. Laser-Based Cell Printing. In: Ovsianikov A, Yoo J, Mironov V, editors. 3D Printing and Biofabrication. Cham: Springer International Publishing; 2016. p. 1-27.

2015

Kufelt O, El-Tamer A, Sehring C, Meissner M, Schlie-Wolter S, Chichkov BN. Water-soluble photopolymerizable chitosan hydrogels for biofabrication via two-photon polymerization. Acta biomaterialia. 2015;18:186-95.

Chichkov B, Zywiety U, Koch L. Laser printing of silicon nanoparticles and living cells. SPIE Newsroom. 03/2015. DOI: 10.1117/2.1201503.005750

Timashev PS, Demina TS, Minaev NV, Bardakova KN, Koroleva AV, Kufelt OA, Chichkov BN, Panchenko VY, Akopova TA, Bagratashvili VN. Fabrication of Microstructured Materials Based on Chitosan and Its Derivatives Using Two-Photon Polymerization. High Energy Chemistry. 2015;49(4):300-3.

Kufelt O, El-Tamer A, Sehring C, Meissner M, Schlie-Wolter S, Chichkov BN. Water-Soluble Photopolymerizable Chitosan Hydrogels for Biofabrication Via Two-Photon Polymerization. Acta Biomater. 2015;18:186-95.

Koroleva A, Deiwick A, Nguyen A, Schlie-Wolter S, Narayan R, Timashev P, Popov V, Bagratashvili V, Chichkov B. Osteogenic Differentiation of Human Mesenchymal Stem Cells in 3-D Zr-Si Organic-Inorganic Scaffolds Produced by Two-Photon Polymerization Technique. PLoS One. 2015;10(2):e0118164.

Koch L, Michael S, Reimers K, Vogt PM, Chichkov B. Chapter 13 - Bioprinting for Skin. In: Zhang LG, Fisher JP, Leong KW, editors. 3d Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine: Academic Press; 2015. p. 281-306.

2014

Zywietz U, Reinhardt C, Evlyukhin A, Birr T, Chichkov B. Generation and Patterning of Si Nanoparticles by Femtosecond Laser Pulses. Applied Physics A. 2014;114(1):45-50.

Zywietz U, Evlyukhin AB, Reinhardt C, Chichkov BN. Laser Printing of Silicon Nanoparticles with Resonant Optical Electric and Magnetic Responses. Nat Commun. 2014;5:3402.

Popov VK, Komlev VS, Chichkov BN. Calcium Phosphate Blossom for Bone Tissue Engineering. Materials Today. 2014;17(2):96-7.

Evlyukhin AB, Eriksen RL, Cheng W, Beermann J, Reinhardt C, Petrov A, Prorok S, Eich M, Chichkov BN, Bozhevolnyi SI. Optical Spectroscopy of Single Si Nanocylinders with Magnetic and Electric Resonances. Sci Rep. 2014;4:4126.

2013

Obata K, El-Tamer A, Koch L, Hinze U, Chichkov BN. High-Aspect 3d Two-Photon Polymerization Structuring with Widened Objective Working Range (Wow-2pp). Light Sci Appl. 2013;2:e116.

Obata K, Chichkov BN. Advanced Femtosecond Laser Micro/Nanostructuring Using Phase Modulation Technique. International Journal of Optomechatronics. 2013;7(4):296-303.

Kurselis K, Kiyan R, Bagratashvili VN, Popov VK, Chichkov BN. 3d Fabrication of All-Polymer Conductive Microstructures by Two Photon Polymerization. Opt Express. 2013;21(25):31029-35.

Kiyan Y, Kurselis K, Kiyan R, Haller H, Chichkov BN, Dumler I. Urokinase Receptor Counteracts Vascular Smooth Muscle Cell Functional Changes Induced by Surface Topography. Theranostics. 2013;3(7):516-26.

Gittard SD, Koroleva A, Nguyen AK, Fadeeva E, Gaidukeviciute A, Schlie-Wolter S, Narayan RJ, Chichkov B. Two-Photon Polymerization Microstructuring in Regenerative Medicine. Front Biosci (Elite Ed). 2013;5:602-9.

De Marco C, Gaidukeviciute A, Kiyan R, Eaton SM, Levi M, Osellame R, Chichkov BN, Turri S. A New Perfluoropolyether-Based Hydrophobic and Chemically Resistant Photoresist Structured by Two-Photon Polymerization. Langmuir. 2013;29(1):426-31.

Allemann R, Stachs O, Falke K, Schmidt W, Siewert S, Sternberg K, Chichkov B, Wree A, Schmitz KP, Guthoff RF. [New Concepts for Pressure-Controlled Glaucoma Implants]. Ophthalmologe. 2013;110(8):733-9. Neue Konzepte fur druckgesteuerte Glaukomimplantate.

2012

Schlie S, Gruene M, Dittmar H, Chichkov BN. Dynamics of Cell Attachment: Adhesion Time and Force. Tissue Eng Part C Methods. 2012;18(9):688-96.

Schlie S, Fadeeva E, Koroleva A, Chichkov BN. Laser-Engineered Topography: Correlation between Structure Dimensions and Cell Control. J Mater Sci Mater Med. 2012;23(11):2813-9.

Osipov V, Doskolovich L, Bezus E, Cheng W, Gaidukeviciute A, Chichkov B. Fabrication of Three-Focal Diffractive Lenses by Two-Photon Polymerization Technique. Applied Physics A. 2012;107(3):525-9.

Kuršelis K, Kiyan R, Chichkov BN. Formation of Corrugated and Porous Steel Surfaces by Femtosecond Laser Irradiation. Applied Surface Science. 2012;258(22):8845-52.

Koroleva A, Gill AA, Ortega I, Haycock JW, Schlie S, Gittard SD, Chichkov BN, Claeyssens F. Two-Photon Polymerization-Generated and Micromolding-Replicated 3d Scaffolds for Peripheral Neural Tissue Engineering Applications. Biofabrication. 2012;4(2):025005.

Koch L, Deiwick A, Schlie S, Michael S, Gruene M, Coger V, Zychlinski D, Schambach A, Reimers K, Vogt PM, Chichkov B. Skin Tissue Generation by Laser Cell Printing. Biotechnol Bioeng. 2012;109(7):1855-63.

Klopsch C, Gabel R, Kaminski A, Mark P, Wang W, Toelk A, Delyagina E, Kleiner G, Koch L, Chichkov B, Mela P, Jockenhoevel S, Ma N, Steinhoff G. Spray- and Laser-Assisted Biomaterial Processing for Fast and Efficient Autologous Cell-Plus-Matrix Tissue Engineering. J Tissue Eng Regen Med. 2012. Epub 2012/12/05.

Evlyukhin AB, Novikov SM, Zywietz U, Eriksen RL, Reinhardt C, Bozhevolnyi SI, Chichkov BN. Demonstration of Magnetic Dipole Resonances of Dielectric Nanospheres in the Visible Region. Nano Lett. 2012;12(7):3749-55.

Emons M, Obata K, Binhammer T, Ovsianikov A, Chichkov BN, Morgner U. Two-Photon Polymerization Technique with Sub-50 Nm Resolution by Sub-10 Fs Laser Pulses. Optical Materials Express. 2012;2(7):942-7.

Boehm RD, Chen B, Gittard SD, Chichkov BN, Monteiro-Riviere NA, Nasir A, Narayan RJ. Two-Photon Polymerization/Micromolding of Microscale Barbs for Medical Applications. Journal of Adhesion Science and Technology. 2012;28(3-4):387-98.

Siewert S, Schultze C, Schmidt W, Hinze U, Chichkov B, Wree A, Sternberg K, Allemann R, Guthoff R, Schmitz KP. Development of a Micro-Mechanical Valve in a Novel Glaucoma Implant. Biomed Microdevices. 2012;14(5):907-20.

2011

Schlie S, Fadeeva E, Koroleva A, Ovsianikov A, Koch J, Ngezahayo A, Chichkov BN. Laser-Based Nanoengineering of Surface Topographies for Biomedical Applications. Photonics and Nanostructures - Fundamentals and Applications. 2011;9(2):159-62.

Ovsianikov A, Deiwick A, Van Vlierberghe S, Pflaum M, Wilhelmi M, Dubruel P, Chichkov B. Laser Fabrication of 3d Gelatin Scaffolds for the Generation of Bioartificial Tissues. Materials. 2011;4(1):288.

Ovsianikov A, Deiwick A, Van Vlierberghe S, Dubruel P, Moller L, Drager G, Chichkov B. Laser Fabrication of Three-Dimensional Cad Scaffolds from Photosensitive Gelatin for Applications in Tissue Engineering. Biomacromolecules. 2011;12(4):851-8.

Kuznetsov AI, Evlyukhin AB, Goncalves MR, Reinhardt C, Koroleva A, Arnedillo ML, Kiyan R, Marti O, Chichkov BN. Laser Fabrication of Large-Scale Nanoparticle Arrays for Sensing Applications. ACS Nano. 2011;5(6):4843-9.

Suriano R, Kuznetsov A, Eaton SM, Kiyan R, Cerullo G, Osellame R, Chichkov BN, Levi M, Turri S. Femtosecond Laser Ablation of Polymeric Substrates for the Fabrication of Microfluidic Channels. Applied Surface Science. 2011;257(14):6243-50.

2010

Obata K, Koch J, Hinze U, Chichkov BN. Multi-Focus Two-Photon Polymerization Technique Based on Individually Controlled Phase Modulation. Opt Express. 2010;18(16):17193-200.

Narayan RJ, Doraiswamy A, Chrisey DB, Chichkov BN. Medical Prototyping Using Two Photon Polymerization. Materials Today. 2010;13(12):42-8.

2009

Heinroth F, Bremer I, Münzer S, Behrens P, Reinhardt C, Passinger S, Ohrt C, Chichkov B. Microstructured Templates Produced Using Femtosecond Laser Pulses as Templates for the Deposition of Mesoporous Silicas. Microporous and Mesoporous Materials. 2009;119(1–3):104-8.

Gittard SD, Ovsianikov A, Monteiro-Riviere NA, Lusk J, Morel P, Minghetti P, Lenardi C, Chichkov BN, Narayan RJ. Fabrication of Polymer Microneedles Using a Two-Photon Polymerization and Micromolding Process. J Diabetes Sci Technol. 2009;3(2):304-11.

Farsari M, Chichkov BN. Materials Processing: Two-Photon Fabrication. Nat Photon. 2009;3(8):450-2.

Kuznetsov AI, Koch J, Chichkov BN. Nanostructuring of Thin Gold Films by Femtosecond Lasers. Applied Physics A. 2009;94(2):221-30.

2008

Hartmann N, Franzka S, Koch J, Ostendorf A, Chichkov BN. Subwavelength Patterning of Alkylsiloxane Monolayers Via Nonlinear Processing with Single Femtosecond Laser Pulses. Applied Physics Letters. 2008;92(22):223111.

Dinca V, Kasotakis E, Catherine J, Mourka A, Ranella A, Ovsianikov A, Chichkov BN, Farsari M, Mitraki A, Fotakis C. Directed Three-Dimensional Patterning of Self-Assembled Peptide Fibrils. Nano Lett. 2008;8(2):538-43.

2007

Schlie S, Ngezahayo A, Ovsianikov A, Fabian T, Kolb HA, Haferkamp H, Chichkov BN. Three-Dimensional Cell Growth on Structures Fabricated from Ormocer by Two-Photon Polymerization Technique. J Biomater Appl. 2007;22(3):275-87.

Ovsianikov A, Schlie S, Ngezahayo A, Haverich A, Chichkov BN. Two-Photon Polymerization Technique for Microfabrication of Cad-Designed 3d Scaffolds from Commercially Available Photosensitive Materials. J Tissue Eng Regen Med. 2007;1(6):443-9.

Ovsianikov A, Ostendorf A, Chichkov BN. Three-Dimensional Photofabrication with Femtosecond Lasers for Applications in Photonics and Biomedicine. Applied Surface Science. 2007;253(15):6599-602.

Barcikowski S, Hahn A, Kabashin AV, Chichkov BN. Properties of Nanoparticles Generated During Femtosecond Laser Machining in Air and Water. Applied Physics A. 2007;87(1):47-55.

Unit 7.3 - Nanoparticles

2017

Polyak A, Naszalyi Nagy L, Mihaly J, Gorres S, Wittneben A, Leiter I, Bankstahl JP, Sajti L, Kellermayer M, Zrinyi M, Ross TL. Preparation and 68Ga-radiolabeling of porous zirconia nanoparticle platform for PET/CT-imaging guided drug delivery. J Pharm Biomed Anal. 2017;137:146-50.

2016

Almansour M, Sajti L, Melhim W, Jarrar BM. Ultrastructural hepatocytic alterations induced by silver nanoparticle toxicity. Ultrastruct Pathol. 2016;40(2):92-100.

Almansour M, Sajti CL, Shraideh Z, Jarrar B. Pulmonary Histological Alterations Induced by 20 nm Silver Nanoparticles. J Nano Res-Sw. 2016;35:104-14.

2015

Almansour M, Sajti L, Melhim W, Jarrar B. Ultrastructural Hepatic Alterations Induced by 35 Nm Zinc Oxide Nanoparticles. Nanoscience and Nanotechnology Letters. 2015;7(9):763-9.

Barchanski A, Funk D, Wittich O, Tegenkamp C, Chichkov BN, Sajti CL. Picosecond Laser Fabrication of Functional Gold–Antibody Nanoconjugates for Biomedical Applications. The Journal of Physical Chemistry C. 2015;119(17):9524-33.

Almansour M, Sajti CL, Shraideh Z, Jarrar B. Pulmonary Histological Alterations Induced by 20 nm Silver Nanoparticles. Journal of Nano Research. 2015;35: 104-114.

Karapetyan A, Reymers A, Giorgio S, Fauquet C, Sajti L, Nitsche S, Nersesyan M, Gevorgyan V, Marine W. Cuprous Oxide Thin Films Prepared by Thermal Oxidation of Copper Layer. Morphological and Optical Properties. Journal of Luminescence. 2015;159:325-32.

Barchanski A, Taylor U, Sajti LC, Gamrad L, Kues AW, Rath D, Barcikowski S. Bioconjugated Gold Nanoparticles Penetrate into Spermatozoa Depending on Plasma Membrane Status. Journal of biomedical nanotechnology. 2015;11(in press).

2014

Pikramenou Z, McCallion C, Carreira S, Dobson P, Brown K, Diaz Fernandez YA, Abdollah M, Zhou D, Sun D, Moise S, Litti L, Yung LL, Borsley S, Dragneva N, Barchanski A, El-Sayed M, Heuer-Jungemann A, Pallares RM, Tsang E, Barry N, Mitchell S, Thanh NTK, Thanou M, Parkin I, Ray P, Jones R. Other Nanoparticles: General Discussion. Faraday Discussions. 2014;175(0):289-303.

Taylor U, Garrels W, Barchanski A, Peterson S, Sajti L, Lucas-Hahn A, Gamrad L, Baulain U, Klein S, Kues WA, Barcikowski S, Rath D. Injection of Ligand-Free Gold and Silver Nanoparticles into Murine Embryos Does Not Impact Pre-Implantation Development. Beilstein Journal of Nanotechnology. 2014;5:677-88.

Taylor U, Barchanski A, Petersen S, Kues WA, Baulain U, Gamrad L, Sajti L, Barcikowski S, Rath D. Gold Nanoparticles Interfere with Sperm Functionality by Membrane Adsorption without Penetration. Nanotoxicology. 2014;8 Suppl 1:118-27. Epub 2013/12/03.

Hess C, Schwenke A, Wagener P, Franzka S, Laszlo Sajti C, Pflaum M, Wiegmann B, Haverich A, Barcikowski S. Dose-Dependent Surface Endothelialization and Biocompatibility of Polyurethane Noble Metal Nanocomposites. J Biomed Mater Res A. 2014;102(6):1909-20. Epub 2013/07/16.

Bergmann C, Schwenke A, Sajti L, Chichkov B, Fischer H. Temperature-Dependent Morphology Changes of Noble Metal Tricalcium Phosphate-Nanocomposites. Ceramics International. 2014;40(6):7931-9.

Barchanski A, Evlyukhin AB, Koroleva A, Reinhardt C, Sajti CL, Zywietz U, Chichkov B. Laser Generation and Printing of Nanoparticles. In: Veiko VP, Konov VI, editors. Fundamentals of Laser-Assisted Micro- and Nanotechnologies: Springer International Publishing; 2014. p. 103-23.

2013

Sowa-Söhle Eveline N, Schwenke A, Wagener P, Weiss A, Wiegel H, Sajti Csaba L, Haverich A, Barcikowski S, Loos A. Antimicrobial Efficacy, Cytotoxicity, and Ion Release of Mixed Metal (Ag, Cu, Zn, Mg) Nanoparticle Polymer Composite Implant Material. BioNanoMaterials2013. p. 217.

Schwenke A, Wagener P, Weiß A, Klimenta K, Wiegel H, Sajti L, Barcikowski S. Laserbasierte Generierung Matrixbinderfreier Nanopartikel-Polymerkomposite Für Bioaktive Medizinprodukte/Laser-Based Generation of Nanocomposites without Matrix-Coupling Agents for Bioactive Medical Devices. Chemie Ingenieur Technik. 2013;85(5):740-6.

Schwenke A, Dalüge H, Kiyan R, Sajti CL, Chichkov B. Non-Agglomerated Gold-Pmma Nanocomposites by in Situ-Stabilized Laser Ablation in Liquid Monomer for Optical Applications. Applied Physics A. 2013;111(2):451-7.

Menéndez-Manjón A, Schwenke A, Steinke T, Meyer M, Giese U, Wagener P, Barcikowski S. Ligand-Free Gold–Silver Nanoparticle Alloy Polymer Composites Generated by Picosecond Laser Ablation in Liquid Monomer. Applied Physics A. 2013;110(2):343-50.

Bagga K, Barchanski A, Intartaglia R, Dante S, Marotta R, Diaspro A, Sajti CL, Brandi F. Laser-Assisted Synthesis of Staphylococcus Aureus Protein-Capped Silicon Quantum Dots as Bio-Functional Nanoprobes. Laser Physics Letters. 2013;10(6):065603.

2012

Wagener P, Schwenke A, Barcikowski S. How Citrate Ligands Affect Nanoparticle Adsorption to Microparticle Supports. Langmuir. 2012;28(14):6132-40.

Taylor U, Barchanski A, Garrels W, Klein S, Kues W, Barcikowski S, Rath D. Toxicity of Gold Nanoparticles on Somatic and Reproductive Cells. In: Zahavy E, Ordentlich A, Yitzhaki S, Shafferman A, editors. Nano-Biotechnology for Biomedical and Diagnostic Research: Springer Netherlands; 2012. p. 125-33.

Intartaglia R, Barchanski A, Bagga K, Genovese A, Das G, Wagener P, Di Fabrizio E, Diaspro A, Brandi F, Barcikowski S. Bioconjugated Silicon Quantum Dots from One-Step Green Synthesis. Nanoscale. 2012;4(4):1271-4.

Hahn A, Fuhlrott J, Loos A, Barcikowski S. Cytotoxicity and Ion Release of Alloy Nanoparticles. J Nanopart Res. 2012;14(1):1-10.

Grade S, Eberhard J, Wagener P, Winkel A, Sajti CL, Barcikowski S, Stiesch M. Therapeutic Window of Ligand-Free Silver Nanoparticles in Agar-Embedded and Colloidal State: In Vitro Bactericidal Effects and Cytotoxicity. Advanced Engineering Materials. 2012;14(5):B231-B9.

Evlyukhin AB, Novikov SM, Zywietz U, Eriksen RL, Reinhardt C, Bozhevolnyi SI, Chichkov BN. Demonstration of Magnetic Dipole Resonances of Dielectric Nanospheres in the Visible Region. Nano Lett. 2012;12(7):3749-55.

Barchanski A, Hashimoto N, Petersen S, Sajti CL, Barcikowski S. Impact of Spacer and Strand Length on Oligonucleotide Conjugation to the Surface of Ligand-Free Laser-Generated Gold Nanoparticles. Bioconjug Chem. 2012;23(5):908-15.

2011

Wagener P, Faramarzi S, Schwenke A, Rosenfeld R, Barcikowski S. Photoluminescent Zinc Oxide Polymer Nanocomposites Fabricated Using Picosecond Laser Ablation in an Organic Solvent. Applied Surface Science. 2011;257(16):7231-7.

Wagener P, Brandes G, Schwenke A, Barcikowski S. Impact of in Situ Polymer Coating on Particle Dispersion into Solid Laser-Generated Nanocomposites. Phys Chem Chem Phys. 2011;13(11):5120-6.

Schwenke A, Wagener P, Nolte S, Barcikowski S. Influence of Processing Time on Nanoparticle Generation During Picosecond-Pulsed Fundamental and Second Harmonic Laser Ablation of Metals in Tetrahydrofuran. 2011;104(1):77-82.

Sajti CL, Barchanski A, Wagener P, Klein S, Barcikowski S. Delay Time and Concentration Effects During Bioconjugation of Nanosecond Laser-Generated Nanoparticles in a Liquid Flow. The Journal of Physical Chemistry C. 2011;115(12):5094-101.

Petersen S, Barchanski A, Taylor U, Klein S, Rath D, Barcikowski S. Penetratin-Conjugated Gold Nanoparticles − Design of Cell-Penetrating Nanomarkers by Femtosecond Laser Ablation. The Journal of Physical Chemistry C. 2011;115(12):5152-9.

Menéndez-Manjón A, Wagener P, Barcikowski S. Transfer-Matrix Method for Efficient Ablation by Pulsed Laser Ablation and Nanoparticle Generation in Liquids. The Journal of Physical Chemistry C. 2011;115(12):5108-14.

Menéndez-Manjón A, Barcikowski S. Hydrodynamic Size Distribution of Gold Nanoparticles Controlled by Repetition Rate During Pulsed Laser Ablation in Water. Applied Surface Science. 2011;257(9):4285-90.

Jakobi J, Menendez-Manjon A, Chakravadhanula VS, Kienle L, Wagener P, Barcikowski S. Stoichiometry of Alloy Nanoparticles from Laser Ablation of Ptir in Acetone and Their Electrophoretic Deposition on Ptir Electrodes. Nanotechnology. 2011;22(14):145601.

Hahn A, Gunther S, Wagener P, Barcikowski S. Electrochemistry-Controlled Metal Ion Release from Silicone Elastomer Nanocomposites through Combination of Different Metal Nanoparticles. Journal of Materials Chemistry. 2011;21(28):10287-9.

Hahn A, Brandes G, Wagener P, Barcikowski S. Metal Ion Release Kinetics from Nanoparticle Silicone Composites. J Control Release. 2011;154(2):164-70.

Duran MC, Willenbrock S, Barchanski A, Muller JM, Maiolini A, Soller JT, Barcikowski S, Nolte I, Feige K, Murua Escobar H. Comparison of Nanoparticle-Mediated Transfection Methods for DNA Expression Plasmids: Efficiency and Cytotoxicity. J Nanobiotechnology. 2011;9:47. Epub 2011/10/22.

Barchanski A, Taylor U, Klein S, Petersen S, Rath D, Barcikowski S. Golden Perspective: Application of Laser-Generated Gold Nanoparticle Conjugates in Reproductive Biology. Reprod Domest Anim. 2011;46 Suppl 3:42-52.

2010

Walter JG, Petersen S, Stahl F, Scheper T, Barcikowski S. Laser Ablation-Based One-Step Generation and Bio-Functionalization of Gold Nanoparticles Conjugated with Aptamers. J Nanobiotechnology. 2010;8:21.

Taylor U, Klein S, Petersen S, Kues W, Barcikowski S, Rath D. Nonendosomal Cellular Uptake of Ligand-Free, Positively Charged Gold Nanoparticles. Cytometry A. 2010;77(5):439-46.

Sajti C, Petersen S, Menéndez-Manjón A, Barcikowski S. In-Situ Bioconjugation in Stationary Media and in Liquid Flow By femtosecond Laser Ablation. Applied Physics A. 2010;101(2):259-64.

Menéndez-Manjón A, Chichkov BN, Barcikowski S. Influence of Water Temperature on the Hydrodynamic Diameter of Gold Nanoparticles from Laser Ablation. The Journal of Physical Chemistry C. 2010;114(6):2499-504.

Menendez-Manjon A, Barcikowski S, Shafeev AG, Mazhukin IV, Chichkov NB. Influence of Beam Intensity Profile on the Aerodynamic Particle Size Distributions Generated by Femtosecond Laser Ablation. 2010;28(1):45-52.

Klein S, Petersen S, Taylor U, Rath D, Barcikowski S. Quantitative Visualization of Colloidal and Intracellular Gold Nanoparticles by Confocal Microscopy. J Biomed Opt. 2010;15(3):036015.

Jakobi J, Petersen S, Menendez-Manjon A, Wagener P, Barcikowski S. Magnetic Alloy Nanoparticles from Laser Ablation in Cyclopentanone and Their Embedding into a Photoresist. Langmuir. 2010;26(10):6892-7. Epub 2010/04/17.

Hahn A, Stöver T, Paasche G, Löbler M, Sternberg K, Rohm H, Barcikowski S. Therapeutic Window for Bioactive Nanocomposites Fabricated by Laser Ablation in Polymer-Doped Organic Liquids. Advanced Engineering Materials. 2010;12(5):B156-B62.

Barcikowski S, Hahn A, Guggenheim M, Reimers K, Ostendorf A. Biocompatibility of Nanoactuators: Stem Cell Growth on Laser-Generated Nickel–Titanium Shape Memory Alloy Nanoparticles. Journal of Nanoparticle Research. 2010;12(5):1733-42.

Barchanski A, Sajti LC, Sehring C, Petersen S, Barcikowski S. Design of Bi-Functional Bioconjugated Gold Nanoparticles by Pulsed Laser Ablation with Minimized Degradation. 2010.

2009

Petersen S, Soller JT, Wagner S, Richter A, Bullerdiek J, Nolte I, Barcikowski S, Murua Escobar H. Co-Transfection of Plasmid DNA and Laser-Generated Gold Nanoparticles Does Not Disturb the Bioactivity of Gfp-Hmgb1 Fusion Protein. J Nanobiotechnology. 2009;7:6.

Petersen S, Jakobi J, Barcikowski S. In Situ Bioconjugation—Novel Laser Based Approach to Pure Nanoparticle-Conjugates. Applied Surface Science. 2009;255(10):5435-8.

Petersen S, Barcikowski S. In-Situ Bioconjugation - Single Step Approach to Tailored Nanoparticle-Bioconjugates by Ultrashort Pulsed Laser Ablation. 2009;19(8):1167-72.

Petersen S, Barcikowski S. Conjugation Efficiency of Laser-Based Bioconjugation of Gold Nanoparticles with Nucleic Acids. The Journal of Physical Chemistry C. 2009;113(46):19830-5.

Menendez-Manjon A, Jakobi J, Schwabe K, Krauss KJ, Barcikowski S. Mobility of Nanoparticles Generated by Femtosecond Laser Ablation in Liquids and Its Application to Surface Patterning. 2009;4(2):95-9.

Hahn A, Barcikowski S. Production of Bioactive Nanomaterial Using Laser Generated Nanoparticles. 2009;4(1):51-4.

Barsch N, Jakobi J, Weiler S, Barcikowski S. Pure Colloidal Metal and Ceramic Nanoparticles from High-Power Picosecond Laser Ablation in Water and Acetone. Nanotechnology. 2009;20(44):445603.

Bärsch N, Gatti A, Barcikowski S. Improving Laser Ablation of Zirconia by Liquid Films: Multiple Influences of Liquids on Surface Machining and Nanoparticle Generation. 2009;4(1):66-70.

Barcikowski S, Walter J, Hahn A, Koch J, Haloui H, Herrmann T, Gatti A. Picosecond and Femtosecond Laser Machining May Cause Health Risks Related to Nanoparticle Emission. 2009;4(3):159-64.

Barcikowski S, Devesa F, Moldenhauer K. Impact and Structure of Literature on Nanoparticle Generation by Laser Ablation in Liquids. Journal of Nanoparticle Research. 2009;11(8):1883-93.

Petersen S, Jakobi J, Hörtinger A, Barcikowski S. In-Situ Conjugation - Tailored Nanoparticle-Conjugates by Laser Ablation in Liquids. J Laser Micro Nanoen. 2009;4(1):71-4.

2008

Baersch N, Barcikowski S, Baier K. Ultrafast-Laser-Processed Zirconia and Its Adhesion to Dental Cement. 2008;3(2):78-83.

Hahn A, Barcikowski S, Chichkov BN. Influences on Nanoparticle Production during Pulsed Laser Ablation. J Laser Micro Nanoen. 2008;3(2):73-7.

vSattari R, Dieling C, Barcikowski S, Chichkov B. Laser-based Fragmentation of Microparticles for Nanoparticle Generation. J Laser Micro Nanoen. 2008;3(2):100-5.

2007

Sartinska LL, Barchikovski S, Wagenda N, Rud’ BM, Timofeeva II. Laser Induced Modification of Surface Structures. Applied Surface Science. 2007;253(9):4295-9.

Barcikowski S, Menéndez-Manjón A, Chichkov B, Brikas M, Račiukaitis G. Generation of Nanoparticle Colloids by Picosecond and Femtosecond Laser Ablations in Liquid Flow. Applied Physics Letters. 2007;91(8):083113.

Barcikowski S, Hahn A, Kabashin AV, Chichkov BN. Properties of Nanoparticles Generated During Femtosecond Laser Machining in Air and Water. Applied Physics A. 2007;87(1):47-55.

Barcikowski S, Hahn A, Chichkov BN. Nanoparticles as Potential Risk During Femtosecond Laser Ablation. Journal of Laser Applications. 2007;19(2):65-73.

Hahn A, Barcikowski S, Ostendorf A. The nanoparticle risk during pulsed laser ablation. The Laser User Magazine. 2007, 47, 32-33.

Unit 7.4 - Nanosurfaces

2014

Kufelt O, El-Tamer A, Sehring C, Schlie-Wolter S, Chichkov BN. Hyaluronic Acid Based Materials for Scaffolding Via Two-Photon Polymerization. Biomacromolecules. 2014;15(2):650-9.

Fadeeva E, Deiwick A, Chichkov B, Schlie-Wolter S. Impact of Laser-Structured Biomaterial Interfaces on Guided Cell Responses. Interface Focus. 2014;4(1).

Barchanski A, Evlyukhin AB, Koroleva A, Reinhardt C, Sajti CL, Zywietz U, Chichkov B. Laser Generation and Printing of Nanoparticles. In: Veiko VP, Konov VI, editors. Fundamentals of Laser-Assisted Micro- and Nanotechnologies: Springer International Publishing; 2014. p. 103-23.

Skoog SA, Nguyen AK, Kumar G, Zheng J, Goering PL, Koroleva A, Chichkov BN, Narayan RJ. Two-Photon Polymerization of 3-D Zirconium Oxide Hybrid Scaffolds for Long-Term Stem Cell Growth. Biointerphases. 2014;9(2):029014.

2013

Koroleva A, Kufelt O, Schlie-Wolter S, Hinze U, Chichkov B. Laser Microstructured Biodegradable Scaffolds. Biomed Tech (Berl). 2013;58(5):399-405.

Schlie-Wolter S, Ngezahayo A, Chichkov BN. The Selective Role of Ecm Components on Cell Adhesion, Morphology, Proliferation and Communication in Vitro. Exp Cell Res. 2013;319(10):1553-61.

Gittard SD, Koroleva A, Nguyen AK, Fadeeva E, Gaidukeviciute A, Schlie-Wolter S, Narayan RJ, Chichkov B. Two-Photon Polymerization Microstructuring in Regenerative Medicine. Front Biosci (Elite Ed). 2013;5:602-9.

Nguyen AK, Gittard SD, Koroleva A, Schlie S, Gaidukeviciute A, Chichkov BN, Narayan RJ. Two-Photon Polymerization of Polyethylene Glycol Diacrylate Scaffolds with Riboflavin and Triethanolamine Used as a Water-Soluble Photoinitiator. Regen Med. 2013;8(6):725-38.

2012

Paz VF, Emons M, Obata K, Ovsianikov A, Peterhänsel S, Frenner K, Reinhardt C, Chichkov B, Morgner U, Osten W. Development of Functional Sub-100 Nm Structures with 3d Two-Photon Polymerization Technique and Optical Methods for Characterization. Journal of Laser Applications. 2012;24(4):042004.

Schlie S, Gruene M, Dittmar H, Chichkov BN. Dynamics of Cell Attachment: Adhesion Time and Force. Tissue Eng Part C Methods. 2012;18(9):688-96.

Koroleva A, Gittard S, Schlie S, Deiwick A, Jockenhoevel S, Chichkov B. Fabrication of Fibrin Scaffolds with Controlled Microscale Architecture by a Two-Photon Polymerization-Micromolding Technique. Biofabrication. 2012;4(1):015001.

Schlie S, Fadeeva E, Koroleva A, Chichkov B. Laser-Engineered Topography: Correlation between Structure Dimensions and Cell Control. Journal of Materials Science: Materials in Medicine. 2012;23(11):2813-9.

Ovsianikov A, Chichkov BN. Three-Dimensional Microfabrication by Two-Photon Polymerization Technique. Methods Mol Biol. 2012;868:311-25.

Koroleva A, Gill AA, Ortega I, Haycock JW, Schlie S, Gittard SD, Chichkov BN, Claeyssens F. Two-Photon Polymerization-Generated and Micromolding-Replicated 3d Scaffolds for Peripheral Neural Tissue Engineering Applications. Biofabrication. 2012;4(2):025005.

2011

Gittard SD, Nguyen A, Obata K, Koroleva A, Narayan RJ, Chichkov BN. Fabrication of Microscale Medical Devices by Two-Photon Polymerization with Multiple Foci Via a Spatial Light Modulator. Biomed Opt Express. 2011;2(11):3167-78.

Ovsianikov A, Deiwick A, Van Vlierberghe S, Pflaum M, Wilhelmi M, Dubruel P, Chichkov B. Laser Fabrication of 3d Gelatin Scaffolds for the Generation of Bioartificial Tissues. Materials. 2011;4(1):288.

Ovsianikov A, Deiwick A, Van Vlierberghe S, Dubruel P, Moller L, Drager G, Chichkov B. Laser Fabrication of Three-Dimensional Cad Scaffolds from Photosensitive Gelatin for Applications in Tissue Engineering. Biomacromolecules. 2011;12(4):851-8.

Ovsianikov A, Malinauskas M, Schlie S, Chichkov B, Gittard S, Narayan R, Löbler M, Sternberg K, Schmitz KP, Haverich A. Three-Dimensional Laser Micro- and Nano-Structuring of Acrylated Poly(Ethylene Glycol) Materials and Evaluation of Their Cytoxicity for Tissue Engineering Applications. Acta Biomaterialia. 2011;7(3):967-74.

2010

Anastasia K, Sabrina S, Elena F, Shaun DG, Philip M, Aleksandr O, Jürgen K, Roger JN, Boris NC. Microreplication of Laser-Fabricated Surface and Three-Dimensional Structures. Journal of Optics. 2010;12(12):124009.

2009

Ovsianikov A, Shizhou X, Farsari M, Vamvakaki M, Fotakis C, Chichkov BN. Shrinkage of Microstructures Produced by Two-Photon Polymerization of Zr-Based Hybrid Photosensitive Materials. Opt Express. 2009;17(4):2143-8.

Claeyssens F, Hasan EA, Gaidukeviciute A, Achilleos DS, Ranella A, Reinhardt C, Ovsianikov A, Shizhou X, Fotakis C, Vamvakaki M, Chichkov BN, Farsari M. Three-Dimensional Biodegradable Structures Fabricated by Two-Photon Polymerization. Langmuir. 2009;25(5):3219-23.

2008

Dinca V, Kasotakis E, Catherine J, Mourka A, Ranella A, Ovsianikov A, Chichkov BN, Farsari M, Mitraki A, Fotakis C. Directed Three-Dimensional Patterning of Self-Assembled Peptide Fibrils. Nano Lett. 2008;8(2):538-43.

Ovsianikov A, Viertl J, Chichkov B, Oubaha M, MacCraith B, Sakellari I, Giakoumaki A, Gray D, Vamvakaki M, Farsari M, Fotakis C. Ultra-Low Shrinkage Hybrid Photosensitive Material for Two-Photon Polymerization Microfabrication. ACS Nano. 2008;2(11):2257-62.

2007

Schlie S, Ngezahayo A, Ovsianikov A, Fabian T, Kolb HA, Haferkamp H, Chichkov BN. Three-Dimensional Cell Growth on Structures Fabricated from Ormocer by Two-Photon Polymerization Technique. J Biomater Appl. 2007;22(3):275-87.

Ovsianikov A, Ostendorf A, Chichkov BN. Three-Dimensional Photofabrication with Femtosecond Lasers for Applications in Photonics and Biomedicine. Applied Surface Science. 2007;253(15):6599-602.

Ovsianikov A, Schlie S, Ngezahayo A, Haverich A, Chichkov BN. Two-Photon Polymerization Technique for Microfabrication of Cad-Designed 3d Scaffolds from Commercially Available Photosensitive Materials. J Tissue Eng Regen Med. 2007;1(6):443-9.

Unit 7.5 - Biological Laser Printing

2015

Koch L, Michael S, Reimers K, Vogt PM, Chichkov B. Chapter 13 - Bioprinting for Skin. In: Zhang LG, Fisher JP, Leong KW, editors. 3d Bioprinting and Nanotechnology in Tissue Engineering and Regenerative Medicine: Academic Press; 2015. p. 281-306.

2014

Koch L, Deiwick A, Chichkov B. Laser-Based 3d Cell Printing for Tissue Engineering. BioNanoMaterials2014. p. 71.

Deiwick A, Fadeeva E, Koch L, Gebauer R, Chichkov B, et al. Functional Titanium Lotus-Topography Promotes the Osteoinduction of Human Adipose-Derived Stem Cells In Vitro. J Nanomed Nanotechnol 2014, 5:239. doi: 10.4172/2157-7439.1000239

Koch, L. Organe aus dem Drucker – Dreidimensionales „Zell-Drucken“ zur Erzeugung biologischen Gewebes. Autoren Innovations - & Forschungsstandort Deutschland, Sept. 11, 2014

2013

Obata K, El-Tamer A, Koch L, Hinze U, Chichkov BN. High-Aspect 3d Two-Photon Polymerization Structuring with Widened Objective Working Range (Wow-2pp). Light Sci Appl. 2013;2:e116.

Koch L, Gruene M, Unger C, Chichkov B. Laser Assisted Cell Printing. Curr Pharm Biotechnol. 2013;14(1):91-7.

Michael S, Sorg H, Peck CT, Koch L, Deiwick A, Chichkov B, Vogt PM, Reimers K. Tissue Engineered Skin Substitutes Created by Laser-Assisted Bioprinting Form Skin-Like Structures in the Dorsal Skin Fold Chamber in Mice. PLoS One. 2013;8(3):e57741.

2012

Schlie S, Gruene M, Dittmar H, Chichkov BN. Dynamics of Cell Attachment: Adhesion Time and Force. Tissue Eng Part C Methods. 2012;18(9):688-96.

Koch L, Deiwick A, Schlie S, Michael S, Gruene M, Coger V, Zychlinski D, Schambach A, Reimers K, Vogt PM, Chichkov B. Skin Tissue Generation by Laser Cell Printing. Biotechnol Bioeng. 2012;109(7):1855-63.

Klopsch C, Gabel R, Kaminski A, Mark P, Wang W, Toelk A, Delyagina E, Kleiner G, Koch L, Chichkov B, Mela P, Jockenhoevel S, Ma N, Steinhoff G. Spray- and Laser-Assisted Biomaterial Processing for Fast and Efficient Autologous Cell-Plus-Matrix Tissue Engineering. J Tissue Eng Regen Med. 2012. Epub 2012/12/05.

Gruene M. Entwicklung, Charakterisierung und Anwendung eines laserbasierten Drucksystems für lebende Zellen. Cuvillier Verlag, 2012, ISBN 978-3-95404-106-0.

2011

Gruene M, Pflaum M, Deiwick A, Koch L, Schlie S, Unger C, Wilhelmi M, Haverich A, Chichkov BN. Adipogenic Differentiation of Laser-Printed 3d Tissue Grafts Consisting of Human Adipose-Derived Stem Cells. Biofabrication. 2011;3(1):015005.

Gruene M, Unger C, Koch L, Deiwick A, Chichkov B. Dispensing Pico to Nanolitre of a Natural Hydrogel by Laser-Assisted Bioprinting. Biomed Eng Online. 2011;10:19.

Gruene M, Deiwick A, Koch L, Schlie S, Unger C, Hofmann N, Bernemann I, Glasmacher B, Chichkov B. Laser Printing of Stem Cells for Biofabrication of Scaffold-Free Autologous Grafts. Tissue Eng Part C Methods. 2011;17(1):79-87.

Gruene M, Pflaum M, Hess C, Diamantouros S, Schlie S, Deiwick A, Koch L, Wilhelmi M, Jockenhoevel S, Haverich A, Chichkov B. Laser Printing of Three-Dimensional Multicellular Arrays for Studies of Cell-Cell and Cell-Environment Interactions. Tissue Eng Part C Methods. 2011;17(10):973-82.

Gaebel R, Ma N, Liu J, Guan J, Koch L, Klopsch C, Gruene M, Toelk A, Wang W, Mark P, Wang F, Chichkov B, Li W, Steinhoff G. Patterning Human Stem Cells and Endothelial Cells with Laser Printing for Cardiac Regeneration. Biomaterials. 2011;32(35):9218-30.

Unger C, Gruene M, Koch L, Koch J, Chichkov B. Time-Resolved Imaging of Hydrogel Printing Via Laser-Induced Forward Transfer. Applied Physics A. 2011;103(2):271-7.

2010

Ovsianikov A, Gruene M, Pflaum M, Koch L, Maiorana F, Wilhelmi M, Haverich A, Chichkov B. Laser Printing of Cells into 3d Scaffolds. Biofabrication. 2010;2(1):014104.

Koch L, Kuhn S, Sorg H, Gruene M, Schlie S, Gaebel R, Polchow B, Reimers K, Stoelting S, Ma N, Vogt PM, Steinhoff G, Chichkov B. Laser Printing of Skin Cells and Human Stem Cells. Tissue Eng Part C Methods. 2010;16(5):847-54.

Unit 7.6 - Laser Manipulation and Cellular Engineering

2017

Gentemann L, Kalies S, Coffee M, Meyer H, Ripken T, Heisterkamp A, Zweigerdt R, Heinemann D. Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles. Biomed Opt Express. 2017;8(1):177-92.

2016

Krawinkel J, Torres-Mapa ML, Werelius K, Heisterkamp A, Ruttermann S, Romanos GE, Gerhardt-Szep S. Gold Nanoparticle-Mediated Delivery of Molecules into Primary Human Gingival Fibroblasts Using ns-Laser Pulses: A Pilot Study. Materials. 2016;9(5).

Krawinkel J, Torres-Mapa ML, Mhatre E, Kovacs AT, Heisterkamp A. Structural damage of Bacillus subtilis biofilms using pulsed laser interaction with gold thin films. J Biophotonics. 2016.

Krawinkel J, Richter U, Torres-Mapa ML, Westermann M, Gamrad L, Rehbock C, Barcikowski S, Heisterkamp A. Optical and electron microscopy study of laser-based intracellular molecule delivery using peptide-conjugated photodispersible gold nanoparticle agglomerates. J Nanobiotechnology. 2016;14:2.

Ishii A, Ariyasu K, Mitsuhashi T, Heinemann D, Heisterkamp A, Terakawa M. Biodegradable microsphere-mediated cell perforation in microfluidic channel using femtosecond laser. J Biomed Opt. 2016;21(5):55001.

2015

Seiler TG, Ehmke T, Fischinger I, Zapp D, Stachs O, Seiler T, Heisterkamp A. Two-Photon Fluorescence Microscopy for Determination of the Riboflavin Concentration in the Anterior Corneal Stroma When Using the Dresden Protocol. Invest Ophthalmol Vis Sci. 2015;56(11):6740-6.

Schomaker M, Heinemann D, Kalies S, Willenbrock S, Wagner S, Nolte I, Ripken T, Murua Escobar H, Meyer H, Heisterkamp A. Characterization of nanoparticle mediated laser transfection by femtosecond laser pulses for applications in molecular medicine. J Nanobiotechnology. 2015;13:10.

Antonopoulos GC, Steltner B, Heisterkamp A, Ripken T, Meyer H. Tile-Based Two-Dimensional Phase Unwrapping for Digital Holography Using a Modular Framework. PloS one. 2015;10(11):e0143186.

Ehmke T., Knebl A., Heisterkamp A. Four-wave mixing microscopy: A high nonlinear imaging method Multiphoton Microscopy. Biomedical Sciences XV. 2015

Seiler TG, Ehmke T, Fischinger I, Zapp D, Stachs O, Seiler T, Heisterkamp A. Two-Photon Fluorescence Microscopy for Determination of the Riboflavin Concentration in the Anterior Corneal Stroma When Using the Dresden Protocol. Invest Ophthalmol Vis Sci. 2015;56(11):6740-6. Epub 2015/11/17.

Schomaker M, Killian D, Willenbrock S, Heinemann D, Kalies S, Ngezahayo A, Nolte I, Ripken T, Junghanss C, Meyer H, Murua Escobar H, Heisterkamp A. Biophysical Effects in Off-Resonant Gold Nanoparticle Mediated (Gnome) Laser Transfection of Cell Lines, Primary- and Stem Cells Using Fs Laser Pulses. J Biophotonics. 2015;8(8):646-58.

Schomaker M, Heinemann D, Kalies S, Willenbrock S, Wagner S, Nolte I, Ripken T, Murua Escobar H, Meyer H, Heisterkamp A. Characterization of Nanoparticle Mediated Laser Transfection by Femtosecond Laser Pulses for Applications in Molecular Medicine. J Nanobiotechnology. 2015;13:10.

Ehmke T, Knebl A, Reiss S, Fischinger IR, Seiler TG, Stachs O, Heisterkamp A. Spectral Behavior of Second Harmonic Signals from Organic and Non-Organic Materials in Multiphoton Microscopy. AIP Adv. 2015;5(8):084903.

2014

Kalies S, Heinemann D, Schomaker M, Murua Escobar H, Heisterkamp A, Ripken T, Meyer H. Plasmonic Laser Treatment for Morpholino Oligomer Delivery in Antisense Applications. J Biophotonics. 2014;7(10):825-33.

Kalies S, Birr T, Heinemann D, Schomaker M, Ripken T, Heisterkamp A, Meyer H. Enhancement of Extracellular Molecule Uptake in Plasmonic Laser Perforation. J Biophotonics. 2014;7(7):474-82.

Gamrad L, Rehbock C, Krawinkel J, Tumursukh B, Heisterkamp A, Barcikowski S. Charge Balancing of Model Gold-Nanoparticle-Peptide Conjugates Controlled by the Peptide’s Net Charge and the Ligand to Nanoparticle Ratio. The Journal of Physical Chemistry C. 2014;118(19):10302-13.

Ehmke T, Nitzsche TH, Knebl A, Heisterkamp A. Molecular Orientation Sensitive Second Harmonic Microscopy by Radially and Azimuthally Polarized Light. Biomed Opt Express. 2014;5(7):2231-46.

Eberhard J, Loewen H, Kruger A, Donner S, Stumpp N, Patzlaff M, Stachs O, Reichard M, Ripken T, Heisterkamp A, Stiesch M. Non-Invasive in Vivo Imaging by Confocal Laser Scanning Microscopy of Gingival Tissues Following Natural Plaque Deposition. J Clin Periodontol. 2014;41(4):321-6.

2013

Mitchell CA, Kalies S, Cizmar T, Heisterkamp A, Torrance L, Roberts AG, Gunn-Moore FJ, Dholakia K. Femtosecond Optoinjection of Intact Tobacco by-2 Cells Using a Reconfigurable Photoporation Platform. PLoS One. 2013;8(11):e79235.

Heinemann D, Schomaker M, Kalies S, Schieck M, Carlson R, Murua Escobar H, Ripken T, Meyer H, Heisterkamp A. Gold Nanoparticle Mediated Laser Transfection for Efficient Sirna Mediated Gene Knock Down. PLoS One. 2013;8(3):e58604. Epub 2013/03/29.

Donner S, Muller O, Witte F, Bartsch I, Willbold E, Ripken T, Heisterkamp A, Rosenhahn B, Kruger A. In Situ Optical Coherence Tomography of Percutaneous Implant-Tissue Interfaces in a Murine Model. Biomed Tech (Berl). 2013;58(4):359-67.

Burmeister F, Richter S, Richter D, Voigtlander C, Heisterkamp A, Nolte S. Breakthroughs in Photonics 2012: Femtosecond-Laser Nanomachining. Photonics Journal, IEEE. 2013;5(2):0700506-.

Aper T, Teebken OE, Kruger A, Heisterkamp A, Hilfiker A, Haverich A. Development of Implantable Autologous Small-Calibre Vascular Grafts from Peripheral Blood Samples. Zentralbl Chir. 2013;138(2):173-9.

2012

Heinemann D, Schomaker M, Schieck M, Ripken T, Meyer H, Heisterkamp A. Efficient siRNA transfection in cell lines and primary neuronal cells by gold nanoparticle mediated laser transfection. Histology and histopathology. 2012;27(Supplement 1):48.

Schomaker M, Heinemann D, Killian D, Willenbrock S, Ripken T, Junghanss C, Nolte I, Meyer H, Murua Escobar H, Heisterkamp A. Establishment of a non-viral, gold nanoparticle mediated laser transfection method for gene therapeutic approaches. Histology and histopathology. 2012;27(Supplement 1):102-3.

Willenbrock S, Braun O, Baumgart J, Lange S, Junghanss C, Heisterkamp A, Nolte I, Bullerdiek J, Murua Escobar H. Tnf-Alpha Induced Secretion of Hmgb1 from Non-Immune Canine Mammary Epithelial Cells (Mth53a). Cytokine. 2012;57(2):210-20.

Rendall HA, Marchington RF, Praveen BB, Bergmann G, Arita Y, Heisterkamp A, Gunn-Moore FJ, Dholakia K. High-Throughput Optical Injection of Mammalian Cells Using a Bessel Light Beam. Lab Chip. 2012;12(22):4816-20.

Kellner M, Heidrich M, Beigel R, Lorbeer RA, Knudsen L, Ripken T, Heisterkamp A, Meyer H, Kuhnel MP, Ochs M. Imaging of the Mouse Lung with Scanning Laser Optical Tomography (Slot). J Appl Physiol (1985). 2012;113(6):975-83.

2011

Schomaker M, Baumgart J, Motekaitis D, Heinemann D, Krawinkel J, Pangalos M, Bintig W, Boulais E, Lachaine R, St.-Louis Lalonde B, Ngezahayo A, Meunier M, Heisterkamp A, editors. Mechanisms of Gold Nanoparticle Mediated Ultrashort Laser Cell Membrane Perforation. 2011.

Pospiech M, Emons M, Kuetemeyer K, Heisterkamp A, Morgner U. Superresolved Femtosecond Laser Nanosurgery of Cells. Biomed Opt Express. 2011;2(2):264-71.

Muller O, Donner S, Klinder T, Dragon R, Bartsch I, Witte F, Kruger A, Heisterkamp A, Rosenhahn B. Model Based 3d Segmentation and Oct Image Undistortion of Percutaneous Implants. Med Image Comput Comput Assist Interv. 2011;14(Pt 3):454-62.

Lorbeer RA, Heidrich M, Lorbeer C, Ramirez Ojeda DF, Bicker G, Meyer H, Heisterkamp A. Highly Efficient 3d Fluorescence Microscopy with a Scanning Laser Optical Tomograph. Opt Express. 2011;19(6):5419-30.

Kuetemeyer K, Lucas-Hahn A, Petersen B, Niemann H, Heisterkamp A. Femtosecond Laser-Induced Fusion of Nonadherent Cells and Two-Cell Porcine Embryos. J Biomed Opt. 2011;16(8):088001.

Kuetemeyer K, Kensah G, Heidrich M, Meyer H, Martin U, Gruh I, Heisterkamp A. Two-Photon Induced Collagen Cross-Linking in Bioartificial Cardiac Tissue. Opt Express. 2011;19(17):15996-6007.

Kensah G, Gruh I, Viering J, Schumann H, Dahlmann J, Meyer H, Skvorc D, Bar A, Akhyari P, Heisterkamp A, Haverich A, Martin U. A Novel Miniaturized Multimodal Bioreactor for Continuous in Situ Assessment of Bioartificial Cardiac Tissue During Stimulation and Maturation. Tissue Eng Part C Methods. 2011;17(4):463-73.

Kalies S, Kuetemeyer K, Heisterkamp A. Mechanisms of High-Order Photobleaching and Its Relationship to Intracellular Ablation. Biomed Opt Express. 2011;2(4):805-16.

Heinemann D, Schomaker M, Motekaitis D, Krawinkel J, Killian D, Escobar HM, Junghanß C, Heisterkamp A, editors. Gold Nanoparticle Mediated Cell Manipulation Using Fs and Ps Laser Pulses for Cell Perforation and Transfection. 2011.

Heidrich M, Kuhnel MP, Kellner M, Lorbeer RA, Lange T, Winkel A, Stiesch M, Meyer H, Heisterkamp A. 3d Imaging of Biofilms on Implants by Detection of Scattered Light with a Scanning Laser Optical Tomograph. Biomed Opt Express. 2011;2(11):2982-94.

2010

Kuetemeyer K, Rezgui R, Lubatschowski H, Heisterkamp A. Influence of Laser Parameters and Staining on Femtosecond Laser-Based Intracellular Nanosurgery. Biomed Opt Express. 2010;1(2):587-97.

Kuetemeyer K, Lucas-Hahn A, Petersen B, Lemme E, Hassel P, Niemann H, Heisterkamp A. Combined Multiphoton Imaging and Automated Functional Enucleation of Porcine Oocytes Using Femtosecond Laser Pulses. J Biomed Opt. 2010;15(4):046006.

Baumgart J, Bintig W, Ngezahayo A, Lubatschowski H, Heisterkamp A. Fs-Laser-Induced Ca2+ Concentration Change During Membrane Perforation for Cell Transfection. Opt Express. 2010;18(3):2219-29.

2009

Ngezahayo A, Baumgart J, Przemeck S, Kutemeyer K, Kruppe L, Witte F, Bintig W, Lubatschowski H, Heisterkamp A: Intracellular manipulation of single cells using ultrashort laser pulses: mitochondria and cytoskeleton, Eur Cell Biol. 2009;88(Suppl. 59), 76-76.

Schomaker M, Baumgart J, Ngezahayo A, Bullerdiek J, Nolte I, Murua-Escobar H, Lubatschowski H, Heisterkamp A, editors. Nanoparticle Mediated Laser Cell Perforation. 2009.

Schomaker M, Baumgart J, Ngezahayo A, Bullerdiek J, Nolte I, Murua Escobar H, Lubatschowski H, Heisterkamp A, editors. Plasmonic Perforation of Living Cells Using Ultrashort Laser Pulses and Gold Nanoparticles. 2009.

Kütemeyer K, Lucas-Hahn A, Petersen B, Hassel P, Lemme E, Niemann H, Heisterkamp A, editors. Femtosecond Laser Based Enucleation of Porcine Oocytes for Somatic Cell Nuclear Transfer. 2009.

Kuetemeyer K, Baumgart J, Lubatschowski H, Heisterkamp A. Repetition Rate Dependency of Low-Density Plasma Effects During Femtosecond-Laser-Based Surgery of Biological Tissue. Applied Physics B. 2009;97(3):695-9.

Baumgart J, Kuetemeyer K, Bintig W, Ngezahayo A, Ertmer W, Lubatschowski H, Heisterkamp A. Repetition Rate Dependency of Reactive Oxygen Species Formation During Femtosecond Laser-Based Cell Surgery. J Biomed Opt. 2009;14(5):054040.

2008

Baumgart J, Bintig W, Ngezahayo A, Willenbrock S, Murua Escobar H, Ertmer W, Lubatschowski H, Heisterkamp A. Quantified Femtosecond Laser Based Opto-Perforation of Living Gfshr-17 and Mth53 a Cells. Opt Express. 2008;16(5):3021-31.

2007

Heisterkamp A, Baumgart J, Martin U, Ngezahayo A, Murua Escobar H, Nolte I, Lubatschowski H, Laser nanosurgery for stem cell research, Proceedings of LIM, 2007.

Heisterkamp A, Baumgart J, Maxwell IZ, Ngezahayo A, Mazur E, Lubatschowski H. Fs-Laser Scissors for Photobleaching, Ablation in Fixed Samples and Living Cells, and Studies of Cell Mechanics. Methods Cell Biol. 2007;82:293-307.

Baumgart J, Bintig W, Ngezahayo A, Ertmer W, Lubatschowski H, Heisterkamp A, editors. Live Cell Opto-Injection by Femtosecond Laser Pulses. 2007.

Arnold CL, Heisterkamp A, Ertmer W, Lubatschowski H. Computational Model for Nonlinear Plasma Formation in High Na Micromachining of Transparent Materials and Biological Cells. Opt Express. 2007;15(16):10303-17.

Arnold CL, Ertmer W, Lubatschowski H, editors. Modeling of Ultrashort Pulse Propagation and Nonlinear Plasma Formation in Transparent Kerr Media Using Realistic Initial Conditions. 2007.

Unit 7.7 -

2017

Gentemann L, Kalies S, Coffee M, Meyer H, Ripken T, Heisterkamp A, Zweigerdt R, Heinemann D. Modulation of cardiomyocyte activity using pulsed laser irradiated gold nanoparticles. Biomed Opt Express. 2017;8(1):177-92.

2015

Schomaker M, Killian D, Willenbrock S, Heinemann D, Kalies S, Ngezahayo A, Nolte I, Ripken T, Junghanss C, Meyer H, Escobar HM, Heisterkamp A. Biophysical Effects in Off-Resonant Gold Nanoparticle Mediated (Gnome) Laser Transfection of Cell Lines, Primary- and Stem Cells Using Fs Laser Pulses. Journal of Biophotonics. 2015;8(8):646-58.

Kalies S, Keil S, Sender S, Hammer SC, Antonopoulos GC, Schomaker M, Ripken T, Escobar HM, Meyer H, Heinemann D. Characterization of the Cellular Response Triggered by Gold Nanoparticle-Mediated Laser Manipulation. Journal of Biomedical Optics. 2015;20(11).

Kalies S, Antonopoulos GC, Rakoski MS, Heinemann D, Schomaker M, Ripken T, Meyer H. Investigation of Biophysical Mechanisms in Gold Nanoparticle Mediated Laser Manipulation of Cells Using a Multimodal Holographic and Fluorescence Imaging Setup. PLoS One. 2015;10(4).

2014

Kalies S, Gentemann L, Schomaker M, Heinemann D, Ripken T, Meyer H. Surface Modification of Silica Particles with Gold Nanoparticles as an Augmentation of Gold Nanoparticle Mediated Laser Perforation. Biomedical Optics Express. 2014;5(8):2686-96.

Heinemann D, Kalies S, Schomaker M, Ertmer W, Escobar HM, Meyer H, Ripken T. Delivery of Proteins to Mammalian Cells Via Gold Nanoparticle Mediated Laser Transfection. Nanotechnology. 2014;25(24).

2013

Mitchell CA, Kalies S, Cizmar T, Heisterkamp A, Torrance L, Roberts AG, Gunn-Moore FJ, Dholakia K. Femtosecond Optoinjection of Intact Tobacco by-2 Cells Using a Reconfigurable Photoporation Platform. PLoS One. 2013;8(11).

Unit 8.1 - Automated and Quantitative Microscopy of Intracellular Trafficking

2017

Khadivjam B, Stegen C, Hogue-Racine MA, El Bilali N, Dohner K, Sodeik B, Lippe R. The ATP-dependent RNA Helicase DDX3X modulates Herpes Simplex Virus Type 1 Gene Expression. Journal of virology. 2017.

2016

Wnek M, Ressel L, Ricci E, Rodriguez-Martinez C, Guerrero JC, Ismail Z, Smith C, Kipar A, Sodeik B, Chinnery PF, Solomon T, Griffiths MJ. Herpes simplex encephalitis is linked with selective mitochondrial damage; a post-mortem and in vitro study. Acta Neuropathol. 2016;132(3):433-51.

Ivanova L, Buch A, Dohner K, Pohlmann A, Binz A, Prank U, Sandbaumhuter M, Bauerfeind R, Sodeik B. Conserved Tryptophan Motifs in the Large Tegument Protein pUL36 Are Required for Efficient Secondary Envelopment of Herpes Simplex Virus Capsids. Journal of virology. 2016;90(11):5368-83.

Brunnemann AK, Liermann K, Deinhardt-Emmer S, Maschkowitz G, Pohlmann A, Sodeik B, Fickenscher H, Sauerbrei A, Krumbholz A. Recombinant herpes simplex virus type 1 strains with targeted mutations relevant for aciclovir susceptibility. Scientific reports. 2016;6:29903.

Ashford P, Hernandez A, Greco TM, Buch A, Sodeik B, Cristea IM, Grunewald K, Shepherd A, Topf M. HVint: A Strategy for Identifying Novel Protein-Protein Interactions in Herpes Simplex Virus Type 1. Molecular & cellular proteomics : MCP. 2016;15(9):2939-53.

2015

Veloso Alves Pereira I, Buchmann B, Sandmann L, Sprinzl K, Schlaphoff V, Dohner K, Vondran F, Sarrazin C, Manns MP, Pinto Marques Souza de Oliveira C, Sodeik B, Ciesek S, von Hahn T. Primary Biliary Acids Inhibit Hepatitis D Virus (Hdv) Entry into Human Hepatoma Cells Expressing the Sodium-Taurocholate Cotransporting Polypeptide (Ntcp). PLoS One. 2015;10(2):e0117152. Epub 2015/02/04.

Krawczyk A, Dirks M, Kasper M, Buch A, Dittmer U, Giebel B, Wildschutz L, Busch M, Goergens A, Schneweis KE, Eis-Hubinger AM, Sodeik B, Heiligenhaus A, Roggendorf M, Bauer D. Prevention of Herpes Simplex Virus Induced Stromal Keratitis by a Glycoprotein B-Specific Monoclonal Antibody. PLoS One. 2015;10(1):e0116800.

Funk C, Ott M, Raschbichler V, Nagel C-H, Binz A, Sodeik B, Bauerfeind R, Bailer SM. The Herpes Simplex Virus Protein Pul31 Escorts Nucleocapsids to Sites of Nuclear Egress, a Process Coordinated by Its N-Terminal Domain. PLoS Pathogens. 2015;11(6):e1004957.

Bosse JB, Hogue IB, Feric M, Thiberge SY, Sodeik B, Brangwynne CP, Enquist LW. Remodeling Nuclear Architecture Allows Efficient Transport of Herpesvirus Capsids by Diffusion. Proc Natl Acad Sci U S A. 2015;112(42):E5725-33. Epub 2015/10/07.

2014

Schomaker M, Heinemann D, Kalies S, Willenbrock S, Murua Escobar H, Buch A, Sodeik B, Ripken T, Meyer H, editors. Mechanistic Investigations and Molecular Medicine Applications of Gold Nanoparticle Mediated (Gnome) Laser Transfection. 2014.

Radtke K, Anderson F, Sodeik B. A Precipitation-Based Assay to Analyze Interactions of Viral Particles with Cytosolic Host Factors. Methods Mol Biol. 2014;1144:191-208.

Nagel CH, Pohlmann A, Sodeik B. Construction and Characterization of Bacterial Artificial Chromosomes (Bacs) Containing Herpes Simplex Virus Full-Length Genomes. Methods Mol Biol. 2014;1144:43-62.

Kelly BJ, Bauerfeind R, Binz A, Sodeik B, Laimbacher AS, Fraefel C, Diefenbach RJ. The Interaction of the Hsv-1 Tegument Proteins Pul36 and Pul37 Is Essential for Secondary Envelopment During Viral Egress. Virology. 2014;454-455:67-77.

Devadas D, Koithan T, Diestel R, Prank U, Sodeik B, Dohner K. Herpes Simplex Virus Internalization into Epithelial Cells Requires Na+/H+ Exchangers and P21-Activated Kinases but Neither Clathrin- nor Caveolin-Mediated Endocytosis. J Virol. 2014;88(22):13378-95.

Anderson F, Savulescu AF, Rudolph K, Schipke J, Cohen I, Ibiricu I, Rotem A, Grünewald K, Sodeik B, Harel A. Targeting of Viral Capsids to Nuclear Pores in a Cell-Free Reconstitution System. Traffic. 2014;15(11):1266-81.

2013

Schudt G, Kolesnikova L, Dolnik O, Sodeik B, Becker S. Live-Cell Imaging of Marburg Virus-Infected Cells Uncovers Actin-Dependent Transport of Nucleocapsids over Long Distances. Proc Natl Acad Sci U S A. 2013;110(35):14402-7.

Sandbaumhuter M, Dohner K, Schipke J, Binz A, Pohlmann A, Sodeik B, Bauerfeind R. Cytosolic Herpes Simplex Virus Capsids Not Only Require Binding Inner Tegument Protein Pul36 but Also Pul37 for Active Transport Prior to Secondary Envelopment. Cell Microbiol. 2013;15(2):248-69.

Nygardas M, Paavilainen H, Muther N, Nagel CH, Roytta M, Sodeik B, Hukkanen V. A Herpes Simplex Virus-Derived Replicative Vector Expressing Lif Limits Experimental Demyelinating Disease and Modulates Autoimmunity. PLoS One. 2013;8(5):e64200.

Lin AE, Greco TM, Dohner K, Sodeik B, Cristea IM. A Proteomic Perspective of Inbuilt Viral Protein Regulation: Pul46 Tegument Protein Is Targeted for Degradation by Icp0 During Herpes Simplex Virus Type 1 Infection. Mol Cell Proteomics. 2013;12(11):3237-52.

Borst EM, Kleine-Albers J, Gabaev I, Babic M, Wagner K, Binz A, Degenhardt I, Kalesse M, Jonjic S, Bauerfeind R, Messerle M. The Human Cytomegalovirus Ul51 Protein Is Essential for Viral Genome Cleavage-Packaging and Interacts with the Terminase Subunits Pul56 and Pul89. J Virol. 2013;87(3):1720-32. Epub 2012/11/24.

2012

Voelkel C, Galla M, Dannhauser PN, Maetzig T, Sodeik B, Schambach A, Baum C. Pseudotype-Independent Nonspecific Uptake of Gammaretroviral and Lentiviral Particles in Human Cells. Hum Gene Ther. 2012;23(3):274-86. Epub 2011/10/21.

Stankov MV, Panayotova-Dimitrova D, Leverkus M, Vondran FW, Bauerfeind R, Binz A, Behrens GM. Autophagy Inhibition Due to Thymidine Analogues as Novel Mechanism Leading to Hepatocyte Dysfunction and Lipid Accumulation. AIDS. 2012;26(16):1995-2006. Epub 2012/08/24.

Sodeik B, Messerle M, Schulz TF. Herpesviren. In: Suerbaum S, Hahn H, Burchard G-D, Kaufmann SE, Schulz T, editors. Medizinische Mikrobiologie Und Infektiologie: Springer Berlin Heidelberg; 2012. p. 540-61.

Snijder B, Sacher R, Ramo P, Liberali P, Mench K, Wolfrum N, Burleigh L, Scott CC, Verheije MH, Mercer J, Moese S, Heger T, Theusner K, Jurgeit A, Lamparter D, Balistreri G, Schelhaas M, De Haan CA, Marjomaki V, Hyypia T, Rottier PJ, Sodeik B, Marsh M, Gruenberg J, Amara A, Greber U, Helenius A, Pelkmans L. Single-Cell Analysis of Population Context Advances Rnai Screening at Multiple Levels. Mol Syst Biol. 2012;8:579.

Schipke J, Pohlmann A, Diestel R, Binz A, Rudolph K, Nagel CH, Bauerfeind R, Sodeik B. The C Terminus of the Large Tegument Protein Pul36 Contains Multiple Capsid Binding Sites That Function Differently During Assembly and Cell Entry of Herpes Simplex Virus. J Virol. 2012;86(7):3682-700.

Nagel CH, Dohner K, Binz A, Bauerfeind R, Sodeik B. Improper Tagging of the Non-Essential Small Capsid Protein Vp26 Impairs Nuclear Capsid Egress of Herpes Simplex Virus. PLoS One. 2012;7(8):e44177.

2011

Rode K, Dohner K, Binz A, Glass M, Strive T, Bauerfeind R, Sodeik B. Uncoupling Uncoating of Herpes Simplex Virus Genomes from Their Nuclear Import and Gene Expression. J Virol. 2011;85(9):4271-83.

Ibiricu I, Huiskonen JT, Dohner K, Bradke F, Sodeik B, Grunewald K. Cryo Electron Tomography of Herpes Simplex Virus During Axonal Transport and Secondary Envelopment in Primary Neurons. PLoS Pathog. 2011;7(12):e1002406.

2010

Radtke K, Kieneke D, Wolfstein A, Michael K, Steffen W, Scholz T, Karger A, Sodeik B. Plus- and Minus-End Directed Microtubule Motors Bind Simultaneously to Herpes Simplex Virus Capsids Using Different Inner Tegument Structures. PLoS Pathog. 2010;6(7):e1000991.

2009

Zhang J, Nagel CH, Sodeik B, Lippe R. Early, Active, and Specific Localization of Herpes Simplex Virus Type 1 Gm to Nuclear Membranes. J Virol. 2009;83(24):12984-97.

Roos WH, Radtke K, Kniesmeijer E, Geertsema H, Sodeik B, Wuite GJ. Scaffold Expulsion and Genome Packaging Trigger Stabilization of Herpes Simplex Virus Capsids. Proc Natl Acad Sci U S A. 2009;106(24):9673-8.

Jung C, Ruthardt N, Lewis R, Michaelis J, Sodeik B, Nolde F, Peneva K, Mullen K, Brauchle C. Photophysics of New Water-Soluble Terrylenediimide Derivatives and Applications in Biology. Chemphyschem. 2009;10(1):180-90.

Jirmo AC, Nagel CH, Bohnen C, Sodeik B, Behrens GM. Contribution of Direct and Cross-Presentation to Ctl Immunity against Herpes Simplex Virus 1. J Immunol. 2009;182(1):283-92.

2008

Nagel CH, Dohner K, Fathollahy M, Strive T, Borst EM, Messerle M, Sodeik B. Nuclear Egress and Envelopment of Herpes Simplex Virus Capsids Analyzed with Dual-Color Fluorescence Hsv1(17+). J Virol. 2008;82(6):3109-24.

Maurer UE, Sodeik B, Grunewald K. Native 3d Intermediates of Membrane Fusion in Herpes Simplex Virus 1 Entry. Proc Natl Acad Sci U S A. 2008;105(30):10559-64.

Borst EM, Wagner K, Binz A, Sodeik B, Messerle M. The Essential Human Cytomegalovirus Gene Ul52 Is Required for Cleavage-Packaging of the Viral Genome. J Virol. 2008;82(5):2065-78.

2006

Wolfstein A, Nagel CH, Radtke K, Dohner K, Allan VJ, Sodeik B. The Inner Tegument Promotes Herpes Simplex Virus Capsid Motility Along Microtubules in Vitro. Traffic. 2006;7(2):227-37.

Kollner I, Sodeik B, Schreek S, Heyn H, von Neuhoff N, Germeshausen M, Zeidler C, Kruger M, Schlegelberger B, Welte K, Beger C. Mutations in Neutrophil Elastase Causing Congenital Neutropenia Lead to Cytoplasmic Protein Accumulation and Induction of the Unfolded Protein Response. Blood. 2006;108(2):493-500.

Dohner K, Radtke K, Schmidt S, Sodeik B. Eclipse Phase of Herpes Simplex Virus Type 1 Infection: Efficient Dynein-Mediated Capsid Transport without the Small Capsid Protein Vp26. J Virol. 2006;80(16):8211-24.

Unit 8.2 - Quantative Microscopy in Regeneration

2017

Schrimpf C, Wrede C, Glage S, Hegermann J, Backhaus S, Blasczyk R, Heuft HG, Muller T. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus). Transfusion. 2017;57(1):60-9.

Muhlfeld C, Madsen J, Mackay RM, Schneider JP, Schipke J, Lutz D, Birkelbach B, Knudsen L, Botto M, Ochs M, Clark H. Effect of irradiation/bone marrow transplantation on alveolar epithelial type II cells is aggravated in surfactant protein D deficient mice. Histochemistry and cell biology. 2017;147(1):49-61.

Knudsen L, Ruppert C, Ochs M. Tissue remodelling in pulmonary fibrosis. Cell Tissue Res. 2017;367(3):607-26.

Kling KM, Lopez-Rodriguez E, Pfarrer C, Muhlfeld C, Brandenberger C. Aging exacerbates acute lung injury-induced changes of the air-blood barrier, lung function, and inflammation in the mouse. Am J Physiol Lung Cell Mol Physiol. 2017;312(1):L1-L12.

Grothausmann R, Knudsen L, Ochs M, Muhlfeld C. Digital 3D reconstructions using histological serial sections of lung tissue including the alveolar capillary network. Am J Physiol Lung Cell Mol Physiol. 2017;312(2):L243-L57.

Ebener S, Barnowski S, Wotzkow C, Marti TM, Lopez-Rodriguez E, Crestani B, Blank F, Schmid RA, Geiser T, Funke M. Toll-like receptor 4 activation attenuates profibrotic response in control lung fibroblasts but not in fibroblasts from patients with IPF. Am J Physiol Lung Cell Mol Physiol. 2017;312(1):L42-L55.

2016

Weidemann M, Schuster-Gossler K, Stauber M, Wrede C, Hegermann J, Ott T, Boldt K, Beyer T, Serth K, Kremmer E, Blum M, Ueffing M, Gossler A. CFAP157 is a murine downstream effector of FOXJ1 that is specifically required for flagellum morphogenesis and sperm motility. Development. 2016;143(24):4736-48.

Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knorr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T. Stiff matrix induces switch to pure beta-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes. Basic research in cardiology. 2016;111(6):68.

Schlosser A, Pilecki B, Hemstra LE, Kejling K, Kristmannsdottir GB, Wulf-Johansson H, Moeller JB, Fuchtbauer EM, Nielsen O, Kirketerp-Moller K, Dubey LK, Hansen PB, Stubbe J, Wrede C, Hegermann J, Ochs M, Rathkolb B, Schrewe A, Bekeredjian R, Wolf E, Gailus-Durner V, Fuchs H, Hrabe de Angelis M, Lindholt JS, Holmskov U, Sorensen GL. MFAP4 Promotes Vascular Smooth Muscle Migration, Proliferation and Accelerates Neointima Formation. Arteriosclerosis, thrombosis, and vascular biology. 2016;36(1):122-33.

Schipke J, Grimm C, Arnstein G, Kockskamper J, Sedej S, Muhlfeld C. Cardiomyocyte loss is not required for the progression of left ventricular hypertrophy induced by pressure overload in female mice. J Anat. 2016;229(1):75-81.

Reiter U, Reiter G, Manninger M, Adelsmayr G, Schipke J, Alogna A, Rajces A, Stalder AF, Greiser A, Muhlfeld C, Scherr D, Post H, Pieske B, Fuchsjager M. Early-stage heart failure with preserved ejection fraction in the pig: a cardiovascular magnetic resonance study. J Cardiovasc Magn Reson. 2016;18(1):63.

Ong CB, Kumagai K, Brooks PT, Brandenberger C, Lewandowski RP, Jackson-Humbles DN, Nault R, Zacharewski TR, Wagner JG, Harkema JR. Ozone-Induced Type 2 Immunity in Nasal Airways. Development and Lymphoid Cell Dependence in Mice. Am J Respir Cell Mol Biol. 2016;54(3):331-40.

Ochs M, Knudsen L, Hegermann J, Wrede C, Grothausmann R, Muhlfeld C. Using electron microscopes to look into the lung. Histochemistry and cell biology. 2016;146(6):695-707.

Lopez-Rodriguez E, Gay-Jordi G, Mucci A, Lachmann N, Serrano-Mollar A. Lung surfactant metabolism: early in life, early in disease and target in cell therapy. Cell Tissue Res. 2016.

Lopez-Rodriguez E, Boden C, Echaide M, Perez-Gil J, Kolb M, Gauldie J, Maus UA, Ochs M, Knudsen L. Surfactant dysfunction during overexpression of TGF-beta1 precedes profibrotic lung remodeling in vivo. Am J Physiol Lung Cell Mol Physiol. 2016;310(11):L1260-71.

Kuebler WM, Wittenberg C, Lee WL, Reppien E, Goldenberg NM, Lindner K, Gao Y, Winoto-Morbach S, Drab M, Muhlfeld C, Dombrowsky H, Ochs M, Schutze S, Uhlig S. Thrombin stimulates albumin transcytosis in lung microvascular endothelial cells via activation of acid sphingomyelinase. Am J Physiol Lung Cell Mol Physiol. 2016;310(8):L720-32.

Kruger M, Decker S, Schneider JP, Haverich A, Schega O. [Surgical treatment of acute mediastinitis]. Chirurg. 2016;87(6):478-85.

Kellner M, Heidrich M, Lorbeer RA, Antonopoulos GC, Knudsen L, Wrede C, Izykowski N, Grothausmann R, Jonigk D, Ochs M, Ripken T, Kuhnel MP, Meyer H. A combined method for correlative 3D imaging of biological samples from macro to nano scale. Scientific reports. 2016;6:35606.

Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kuhnel M, Matthieu S, Grothausmann R, Chun J, Roberts JD, Jr., Ochs M, Tager AM. Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization. Am J Respir Cell Mol Biol. 2016;55(1):105-16.

Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, Harger A, Schipke J, Zimmermann A, Schmidt A, Tong M, Ruckenstuhl C, Dammbrueck C, Gross AS, Herbst V, Magnes C, Trausinger G, Narath S, Meinitzer A, Hu Z, Kirsch A, Eller K, Carmona-Gutierrez D, Buttner S, Pietrocola F, Knittelfelder O, Schrepfer E, Rockenfeller P, Simonini C, Rahn A, Horsch M, Moreth K, Beckers J, Fuchs H, Gailus-Durner V, Neff F, Janik D, Rathkolb B, Rozman J, de Angelis MH, Moustafa T, Haemmerle G, Mayr M, Willeit P, von Frieling-Salewsky M, Pieske B, Scorrano L, Pieber T, Pechlaner R, Willeit J, Sigrist SJ, Linke WA, Muhlfeld C, Sadoshima J, Dengjel J, Kiechl S, Kroemer G, Sedej S, Madeo F. Cardioprotection and lifespan extension by the natural polyamine spermidine. Nat Med. 2016;22(12):1428-38.

Busley D, Ochs M, Hoeltig D, Ganter M, Acevedo C, Schmiedl A, Hennig-Pauka I. Characterization of surfactant alterations in pigs infected with Actinobacillus pleuropneumoniae. Exp Lung Res. 2016;42(1):1-13.

Brandenberger C, Muhlfeld C. Mechanisms of lung aging. Cell Tissue Res. 2016.

Bougioukas I, Didilis V, Emigholz J, Waldmann-Beushausen R, Stojanovic T, Muhlfeld C, Schoendube FA, Danner BC. The effect of amifostine on lung ischaemia-reperfusion injury in rats. Interact Cardiovasc Thorac Surg. 2016;23(2):273-9.

Beers MF, Knudsen L, Tomer Y, Maronn J, Zhao M, Ochs M, Mulugeta S. Aberrant lung remodeling in a mouse model of surfactant dysregulation induced by modulation of the Abca3 gene. Ann Anat. 2016.

Bates MA, Brandenberger C, Langohr, II, Kumagai K, Lock AL, Harkema JR, Holian A, Pestka JJ. Silica-Triggered Autoimmunity in Lupus-Prone Mice Blocked by Docosahexaenoic Acid Consumption. PloS one. 2016;11(8):e0160622.

Baisantry A, Bhayana S, Wrede C, Hegermann J, Haller H, Melk A, Schmitt R. The impact of autophagy on the development of senescence in primary tubular epithelial cells. Cell Cycle. 2016;15(21):2973-9.

Baisantry A, Bhayana S, Rong S, Ermeling E, Wrede C, Hegermann J, Pennekamp P, Sorensen-Zender I, Haller H, Melk A, Schmitt R. Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments. Journal of the American Society of Nephrology : JASN. 2016;27(6):1609-16.

Ahuja S, Knudsen L, Chillappagari S, Henneke I, Ruppert C, Korfei M, Gochuico BR, Bellusci S, Seeger W, Ochs M, Guenther A, Mahavadi P. MAP1LC3B overexpression protects against Hermansky-Pudlak syndrome type-1-induced defective autophagy in vitro. Am J Physiol Lung Cell Mol Physiol. 2016;310(6):L519-31.

2015

Willfuhr A, Brandenberger C, Piatkowski T, Grothausmann R, Nyengaard JR, Ochs M, Muhlfeld C. Estimation of the Number of Alveolar Capillaries by the Euler Number (Euler-Poincare Characteristic). Am J Physiol Lung Cell Mol Physiol. 2015:ajplung 00410 2014.

Vital M, Harkema JR, Rizzo M, Tiedje J, Brandenberger C. Alterations of the Murine Gut Microbiome with Age and Allergic Airway Disease. J Immunol Res. 2015;2015:892568.

Schipke J, Roloff K, Kuhn M, Muhlfeld C. Systemic, but Not Cardiomyocyte-Specific, Deletion of the Natriuretic Peptide Receptor Guanylyl Cyclase a Increases Cardiomyocyte Number in Neonatal Mice. Histochem Cell Biol. 2015;144(4):365-75. Epub 2015/06/11.

Muhlfeld C, Hegermann J, Wrede C, Ochs M. A Review of Recent Developments and Applications of Morphometry/Stereology in Lung Research. Am J Physiol Lung Cell Mol Physiol. 2015;309(6):L526-36.

McDonough JE, Knudsen L, Wright AC, Elliott W, Ochs M, Hogg JC. Regional Differences in Alveolar Density in the Human Lung Are Related to Lung Height. J Appl Physiol (1985). 2015;118(11):1429-34.

Lutz D, Gazdhar A, Lopez-Rodriguez E, Ruppert C, Mahavadi P, Gunther A, Klepetko W, Bates JH, Smith B, Geiser T, Ochs M, Knudsen L. Alveolar Derecruitment and Collapse Induration as Crucial Mechanisms in Lung Injury and Fibrosis. Am J Respir Cell Mol Biol. 2015;52(2):232-43.

Kupsch A, Lange A, Hentschel MP, Luck S, Schmidt V, Grothausmann R, Hilger A, Manke I. Missing Wedge Computed Tomography by Iterative Algorithm Directt. J Microsc. 2015.

Knudsen L, Atochina-Vasserman EN, Massa CB, Birkelbach B, Guo CJ, Scott P, Haenni B, Beers MF, Ochs M, Gow AJ. The Role of Inducible Nitric Oxide Synthase for Interstitial Remodeling of Alveolar Septa in Surfactant Protein D-Deficient Mice. Am J Physiol Lung Cell Mol Physiol. 2015;309(9):L959-69. Epub 2015/09/01.

Kellner M, Wehling J, Warnecke G, Heidrich M, Izykowski N, Vogel-Claussen J, Lorbeer RA, Antonopoulos G, Janciauskiene S, Grothausmann R, Knudsen L, Ripken T, Meyer H, Kreipe H, Ochs M, Jonigk D, Kuhnel MP. Correlating 3d Morphology with Molecular Pathology: Fibrotic Remodelling in Human Lung Biopsies. Thorax. 2015.

Katsirntaki K, Mauritz C, Olmer R, Schmeckebier S, Sgodda M, Puppe V, Eggenschwiler R, Duerr J, Schubert SC, Schmiedl A, Ochs M, Cantz T, Salwig I, Szibor M, Braun T, Rathert C, Martens A, Mall MA, Martin U. Bronchoalveolar Sublineage Specification of Pluripotent Stem Cells: Effect of Dexamethasone Plus Camp-Elevating Agents and Keratinocyte Growth Factor. Tissue Eng Part A. 2015;21(3-4):669-82.

Jonigk D, Izykowski N, Rische J, Braubach P, Kuhnel M, Warnecke G, Lippmann T, Kreipe H, Haverich A, Welte T, Gottlieb J, Laenger F. Molecular Profiling in Lung Biopsies of Human Pulmonary Allografts to Predict Chronic Lung Allograft Dysfunction. Am J Pathol. 2015;185(12):3178-88.

Holm AT, Wulf-Johansson H, Hvidsten S, Jorgensen PT, Schlosser A, Pilecki B, Ormhoj M, Moeller JB, Johannsen C, Baun C, Andersen T, Schneider JP, Hegermann J, Ochs M, Gotz AA, Schulz H, de Angelis MH, Vestbo J, Holmskov U, Sorensen GL. Characterization of Spontaneous Air Space Enlargement in Mice Lacking Microfibrillar-Associated Protein 4. Am J Physiol Lung Cell Mol Physiol. 2015;308(11):L1114-24.

Grothausmann R, Kellner M, Heidrich M, Lorbeer RA, Ripken T, Meyer H, Kuehnel MP, Ochs M, Rosenhahn B. Method for 3d Airway Topology Extraction. Comput Math Methods Med. 2015;2015:127010.

Brandenberger C, Ochs M, Mühlfeld C. Assessing Particle and Fiber Toxicology in the Respiratory System: The Stereology Toolbox. Particle and Fibre Toxicology. 2015;12(1):1-15.

Brandenberger C, Hotchkiss JA, Krieger SM, Pottenger LH, Harkema JR. Inhalation Exposure to Ethylene Induces Eosinophilic Rhinitis and Nasal Epithelial Remodeling in Fischer 344 Rats. Chem Biol Interact. 2015.

Boning A, Rohrbach S, Kohlhepp L, Heep M, Hagmuller S, Niemann B, Muhlfeld C. Differences in Ischemic Damage between Young and Old Hearts--Effects of Blood Cardioplegia. Exp Gerontol. 2015;67:3-8. Epub 2015/04/29.

Birkelbach B, Lutz D, Ruppert C, Henneke I, Lopez-Rodriguez E, Gunther A, Ochs M, Mahavadi P, Knudsen L. Linking Progression of Fibrotic Lung Remodeling and Ultrastructural Alterations of Alveolar Epithelial Type Ii Cells in the Amiodarone Mouse Model. Am J Physiol Lung Cell Mol Physiol. 2015;309(1):L63-75.

Becker S, Steinmeyer J, Avsar M, Hoffler K, Salman J, Haverich A, Warnecke G, Ochs M, Schnapper A. Evaluating Acellular Versus Cellular Perfusate Composition During Prolonged Ex Vivo Lung Perfusion after Initial Cold Ischaemia for 24 Hours. Transpl Int. 2015.

Baisantry A, Bhayana S, Rong S, Ermeling E, Wrede C, Hegermann J, Pennekamp P, Sorensen-Zender I, Haller H, Melk A, Schmitt R. Autophagy Induces Prosenescent Changes in Proximal Tubular S3 Segments. J Am Soc Nephrol. 2015.

Schneider JP, Pedersen L, Muhlfeld C, Ochs M. Staining Histological Lung Sections with Sudan Black B or Sudan Iii for Automated Identification of Alveolar Epithelial Type Ii Cells. Acta Histochem. 2015;117(8):675-80. Epub 2015/11/13.

2014

Winkler C, Bahlmann O, Viereck J, Knudsen L, Wedekind D, Hoymann HG, Madsen J, Thum T, Hohlfeld JM, Ochs M. Impact of a Met(11)Thr Single Nucleotide Polymorphism of Surfactant Protein D on Allergic Airway Inflammation in a Murine Asthma Model. Exp Lung Res. 2014;40(4):154-63.

Tahedl D, Wirkes A, Tschanz SA, Ochs M, Muhlfeld C. How Common Is the Lipid Body-Containing Interstitial Cell in the Mammalian Lung? Am J Physiol Lung Cell Mol Physiol. 2014;307(5):L386-94. Epub 2014/06/29.

Slottosch I, Liakopoulos O, Kuhn E, Deppe A, Lopez-Pastorini A, Schwarz D, Neef K, Choi Y-H, Jung K, Mühlfeld C, Wahlers T. Controlled Lung Reperfusion to Reduce Pulmonary Ischaemia/Reperfusion Injury after Cardiopulmonary Bypass in a Porcine Model. Interactive CardioVascular and Thoracic Surgery. 2014;19(6):962-70.

Schneider JP, Ochs M. Alterations of Mouse Lung Tissue Dimensions During Processing for Morphometry: A Comparison of Methods. Am J Physiol Lung Cell Mol Physiol. 2014;306(4):L341-50.

Schipke J, Mayhew TM, Muhlfeld C. Allometry of Left Ventricular Myocardial Innervation. J Anat. 2014;224(4):518-26.

Schipke J, Banmann E, Nikam S, Voswinckel R, Kohlstedt K, Loot AE, Fleming I, Muhlfeld C. The Number of Cardiac Myocytes in the Hypertrophic and Hypotrophic Left Ventricle of the Obese and Calorie-Restricted Mouse Heart. J Anat. 2014;225(5):539-47.

Rudat C, Grieskamp T, Rohr C, Airik R, Wrede C, Hegermann J, Herrmann BG, Schuster-Gossler K, Kispert A. Upk3b Is Dispensable for Development and Integrity of Urothelium and Mesothelium. PLoS One. 2014;9(11):e112112.

Ochs M. Estimating Structural Alterations in Animal Models of Lung Emphysema. Is There a Gold Standard? Ann Anat. 2014;196(1):26-33.

Muhlfeld C. Quantitative Morphology of the Vascularisation of Organs: A Stereological Approach Illustrated Using the Cardiac Circulation. Ann Anat. 2014;196(1):12-9.

Mohamed BA, Barakat AZ, Held T, Elkenani M, Muhlfeld C, Manner J, Adham IM. Respiratory Distress and Early Neonatal Lethality in Hspa4l/Hspa4 Double-Mutant Mice. Am J Respir Cell Mol Biol. 2014;50(4):817-24.

Minocchieri S, Knoch S, Schoel WM, Ochs M, Nelle M. Nebulizing Poractant Alfa Versus Conventional Instillation: Ultrastructural Appearance and Preservation of Surface Activity. Pediatr Pulmonol. 2014;49(4):348-56.

Mahavadi P, Henneke I, Ruppert C, Knudsen L, Venkatesan S, Liebisch G, Chambers RC, Ochs M, Schmitz G, Vancheri C, Seeger W, Korfei M, Guenther A. Altered Surfactant Homeostasis and Alveolar Epithelial Cell Stress in Amiodarone-Induced Lung Fibrosis. Toxicol Sci. 2014;142(1):285-97.

Mahavadi P, Henneke I, Knudsen L, Ruppert C, Venkatesan S, Liebisch G, Chambers RC, Piskulak K, Ochs M, Schmitz G, Vancheri C, Seeger W, Korfei M, Guenther A. Regulation of Macroautophagy in Amiodarone Induced Pulmonary Fibrosis. Pneumologie. 2014;68(02):A18.

Lange A, Hentschel MP, Kupsch A, Hilger A, Manke I, Lück S, Ulm VS, Grothausmann R. Reduction of Missing Wedge Artifacts in Computerised Tomography by Directt. Materials Testing. 2014;56(9):716-21.

Korner C, Kuchenbuch T, Pfeil U, Jung K, Padberg W, Kummer W, Muhlfeld C, Grau V. Low-Dose Adrenomedullin-2/Intermedin(8-47) Reduces Pulmonary Ischemia/Reperfusion Injury. Peptides. 2014;62:49-54.

Knudsen L, Atochina-Vasserman EN, Guo CJ, Scott PA, Haenni B, Beers MF, Ochs M, Gow AJ. Nos2 Is Critical to the Development of Emphysema in Sftpd Deficient Mice but Does Not Affect Surfactant Homeostasis. PLoS One. 2014;9(1):e85722.

Johnson L, Montgomery JB, Schneider JP, Townsend HG, Ochs M, Singh B. Morphometric Examination of the Equine Adult and Foal Lung. Anat Rec (Hoboken). 2014;297(10):1950-62.

Herrmann G, Knudsen L, Madershahian N, Muhlfeld C, Frank K, Rahmanian P, Wahlers T, Wittwer T, Ochs M. Effects of Exogenous Surfactant on the Non-Heart-Beating Donor Lung Graft in Experimental Lung Transplantation - a Stereological Study. J Anat. 2014;224(5):594-602.

Chowdhury A, Herzog C, Hasselbach L, Khouzani HL, Zhang J, Hammerschmidt M, Rudat C, Kispert A, Gaestel M, Menon MB, Tudorache I, Hilfiker-Kleiner D, Muhlfeld C, Schmitto JD, Muller M, Theilmeier G. Expression of Fibulin-6 in Failing Hearts and Its Role for Cardiac Fibroblast Migration. Cardiovasc Res. 2014;103(4):509-20.

Boning A, Hagmuller S, Heep M, Rohrbach S, Niemann B, Muhlfeld C. Is Warm or Cold Calafiore Blood Cardioplegia Better? Hemodynamic, Metabolic, and Electron Microscopic Differences. Thorac Cardiovasc Surg. 2014;62(8):683-9.

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac Fibroblast-Derived Microrna Passenger Strand-Enriched Exosomes Mediate Cardiomyocyte Hypertrophy. J Clin Invest. 2014;124(5):2136-46. Epub 2014/04/20.

Wittwer T, Rahmanian P, Choi YH, Zeriouh M, Karavidic S, Neef K, Christmann A, Piatkowski T, Schnapper A, Ochs M, Muhlfeld C, Wahlers T. Mesenchymal Stem Cell Pretreatment of Non-Heart-Beating-Donors in Experimental Lung Transplantation. J Cardiothorac Surg. 2014;9:151.

2013

Vasilescu DM, Klinge C, Knudsen L, Yin L, Wang G, Weibel ER, Ochs M, Hoffman EA. Stereological Assessment of Mouse Lung Parenchyma Via Nondestructive, Multiscale Micro-Ct Imaging Validated by Light Microscopic Histology. J Appl Physiol (1985). 2013;114(6):716-24. Epub 2012/12/25.

Timpel M, Wanderka N, Grothausmann R, Banhart J. Distribution of Fe-Rich Phases in Eutectic Grains of Sr-Modified Al–10 Wt.% Si–0.1 Wt.% Fe Casting Alloy. Journal of Alloys and Compounds. 2013;558:18-25.

Schneider JP, Ochs M. Stereology of the Lung. Methods Cell Biol. 2013;113:257-94.

Schmeckebier S, Mauritz C, Katsirntaki K, Sgodda M, Puppe V, Duerr J, Schubert SC, Schmiedl A, Lin Q, Palecek J, Draeger G, Ochs M, Zenke M, Cantz T, Mall MA, Martin U. Keratinocyte Growth Factor and Dexamethasone Plus Elevated Camp Levels Synergistically Support Pluripotent Stem Cell Differentiation into Alveolar Epithelial Type Ii Cells. Tissue Eng Part A. 2013;19(7-8):938-51.

Piatkowski T, Muhlfeld C, Borchardt T, Braun T. Reconstitution of the Myocardium in Regenerating Newt Hearts Is Preceded by Transient Deposition of Extracellular Matrix Components. Stem Cells Dev. 2013;22(13):1921-31.

Patra C, van Amerongen MJ, Ghosh S, Ricciardi F, Sajjad A, Novoyatleva T, Mogha A, Monk KR, Muhlfeld C, Engel FB. Organ-Specific Function of Adhesion G Protein-Coupled Receptor Gpr126 Is Domain-Dependent. Proc Natl Acad Sci U S A. 2013;110(42):16898-903.

Ochs M, Muhlfeld C. Quantitative Microscopy of the Lung: A Problem-Based Approach. Part 1: Basic Principles of Lung Stereology. Am J Physiol Lung Cell Mol Physiol. 2013;305(1):L15-22.

Ochs M. Rebuilding the Lung: Signals for a Complex Architectural Task. J Appl Physiol (1985). 2013;114(8):959-60.

Muhlfeld C, Schipke J, Schmidt A, Post H, Pieske B, Sedej S. Hypoinnervation Is an Early Event in Experimental Myocardial Remodelling Induced by Pressure Overload. J Anat. 2013;222(6):634-44.

Muhlfeld C, Ochs M. Quantitative Microscopy of the Lung: A Problem-Based Approach. Part 2: Stereological Parameters and Study Designs in Various Diseases of the Respiratory Tract. Am J Physiol Lung Cell Mol Physiol. 2013;305(3):L205-21.

Muhlfeld C, Knudsen L, Ochs M. Stereology and Morphometry of Lung Tissue. Methods Mol Biol. 2013;931:367-90.

Monz D, Tutdibi E, Mildau C, Shen J, Kasoha M, Laschke MW, Roolfs T, Schmiedl A, Tschernig T, Bieback K, Gortner L. Human Umbilical Cord Blood Mononuclear Cells in a Double-Hit Model of Bronchopulmonary Dysplasia in Neonatal Mice. PLoS One. 2013;8(9):e74740.

Knudsen L, Ochs K, Boxler L, Tornoe I, Lykke-Sorensen G, Mackay RM, Clark HW, Holmskov U, Ochs M, Madsen J. Surfactant Protein D (Sp-D) Deficiency Is Attenuated in Humanised Mice Expressing the Met(11)Thr Short Nucleotide Polymorphism of Sp-D: Implications for Surfactant Metabolism in the Lung. J Anat. 2013;223(6):581-92.

Kirstein MM, Boukouris AE, Pothiraju D, Buitrago-Molina LE, Marhenke S, Schutt J, Orlik J, Kuhnel F, Hegermann J, Manns MP, Vogel A. Activity of the Mtor Inhibitor Rad001, the Dual Mtor and Pi3-Kinase Inhibitor Bez235 and the Pi3-Kinase Inhibitor Bkm120 in Hepatocellular Carcinoma. Liver Int. 2013;33(5):780-93.

Kensah G, Roa Lara A, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Drager G, Ochs M, Haverich A, Gruh I, Martin U. Murine and Human Pluripotent Stem Cell-Derived Cardiac Bodies Form Contractile Myocardial Tissue in Vitro. Eur Heart J. 2013;34(15):1134-46.

Gortner L, Monz D, Mildau C, Shen J, Kasoha M, Laschke MW, Roolfs T, Schmiedl A, Meier C, Tutdibi E. Bronchopulmonary Dysplasia in a Double-Hit Mouse Model Induced by Intrauterine Hypoxia and Postnatal Hyperoxia: Closer to Clinical Features? Ann Anat. 2013;195(4):351-8.

Wittwer T, Madershahian N, Rahmanian P, Choi YH, Neef K, Frank K, Muller-Ehmsen J, Ochs M, Muhlfeld C, Wahlers T. Surfactant Application in Experimental Lung Transplantation. J Heart Lung Transplant. 2013;32(3):355-9.

Gazdhar A, Susuri N, Hostettler K, Gugger M, Knudsen L, Roth M, Ochs M, Geiser T. Hgf Expressing Stem Cells in Usual Interstitial Pneumonia Originate from the Bone Marrow and Are Antifibrotic. PLoS One. 2013;8(6):e65453.

Adam RJ, Michalski AS, Bauer C, Abou Alaiwa MH, Gross TJ, Awadalla MS, Bouzek DC, Gansemer ND, Taft PJ, Hoegger MJ, Diwakar A, Ochs M, Reinhardt JM, Hoffman EA, Beichel RR, Meyerholz DK, Stoltz DA. Air Trapping and Airflow Obstruction in Newborn Cystic Fibrosis Piglets. Am J Respir Crit Care Med. 2013;188(12):1434-41.

Gazdhar A, Temuri A, Knudsen L, Gugger M, Schmid RA, Ochs M, Geiser T. Targeted Gene Transfer of Hepatocyte Growth Factor to Alveolar Type Ii Epithelial Cells Reduces Lung Fibrosis in Rats. Hum Gene Ther. 2013;24(1):105-16.

Arlt T, Grothausmann R, Manke I, Markotter H, Hilger A, Kardjilov N, Totzke C, Banhart J, Kupsch A, Lange A, Hentschel MP, Kruger P, Haussmann J, Hartnig C, Wippermann K. Tomographic methods for fuel cell research. Materials Testing. 2013;55(3):207-13.

2012

Grothausmann R, Zehl G, Manke I, Fiechter S, Bogdanoff P, Dorbandt I, Kupsch A, Lange A, Hentschel M, Schumacher G, Banhart J. Three-Dimentional Characterization of Nano-Particles Catalyst. International Journal of Materials Research, Carl Hanser Verlag, 2012, 103, 135-136.

Vasilescu DM, Gao Z, Saha PK, Yin L, Wang G, Haefeli-Bleuer B, Ochs M, Weibel ER, Hoffman EA. Assessment of Morphometry of Pulmonary Acini in Mouse Lungs by Nondestructive Imaging Using Multiscale Microcomputed Tomography. Proc Natl Acad Sci U S A. 2012;109(42):17105-10. Epub 2012/10/03.

Steinwede K, Maus R, Bohling J, Voedisch S, Braun A, Ochs M, Schmiedl A, Langer F, Gauthier F, Roes J, Welte T, Bange FC, Niederweis M, Buhling F, Maus UA. Cathepsin G and Neutrophil Elastase Contribute to Lung-Protective Immunity against Mycobacterial Infections in Mice. J Immunol. 2012;188(9):4476-87.

Patra C, Talukdar S, Novoyatleva T, Velagala SR, Muhlfeld C, Kundu B, Kundu SC, Engel FB. Silk Protein Fibroin from Antheraea Mylitta for Cardiac Tissue Engineering. Biomaterials. 2012;33(9):2673-80.

Mohamed BA, Barakat AZ, Zimmermann WH, Bittner RE, Muhlfeld C, Hunlich M, Engel W, Maier LS, Adham IM. Targeted Disruption of Hspa4 Gene Leads to Cardiac Hypertrophy and Fibrosis. J Mol Cell Cardiol. 2012;53(4):459-68. Epub 2012/08/14.

Leuenberger A, Gazdhar A, Herrmann G, Ochs M, Geiser T, Knudsen L. Cell-Specific Expression of Human Hgf by Alveolar Type Ii Cells Induces Remodeling of Septal Wall Tissue in the Lung: A Morphometric Study. J Appl Physiol (1985). 2012;113(5):799-807.

Vasilescu DM, Knudsen L, Ochs M, Weibel ER, Hoffman EA. Optimized Murine Lung Preparation for Detailed Structural Evaluation Via Micro-Computed Tomography. J Appl Physiol (1985). 2012;112(1):159-66.

Kellner M, Heidrich M, Beigel R, Lorbeer RA, Knudsen L, Ripken T, Heisterkamp A, Meyer H, Kuhnel MP, Ochs M. Imaging of the Mouse Lung with Scanning Laser Optical Tomography (Slot). J Appl Physiol (1985). 2012;113(6):975-83. Epub 2012/07/17.

Grothausmann R, Gout J, Kühnel M. Voxelizer Plug-in for Blender. 2012.

Grothausmann R, Fiechter S, Beare R, Lehmann G, Kropf H, Vinod Kumar GS, Manke I, Banhart J. Automated Quantitative 3d Analysis of Faceting of Particles in Tomographic Datasets. Ultramicroscopy. 2012;122:65-75. Epub 2012/09/27.

Graulich T, Das SK, Krasteva G, Ruppert C, Wessels L, Hoefler G, Muhlfeld C. Cancer Cachexia Alters Intracellular Surfactant Metabolism but Not Total Alveolar Surface Area. Histochem Cell Biol. 2012;138(5):803-13.

Frenzel E, Korenbaum E, Hegermann J, Ochs M, Koepke J, Koczulla AR, Welte T, Kohnlein T, Janciauskiene S. Does Augmentation with Alpha1-Antitrypsin Affect Neutrophil Extracellular Traps Formation? Int J Biol Sci. 2012;8(7):1023-5.

Emmrich S, Henke K, Hegermann J, Ochs M, Reinhardt D, Klusmann JH. Mirnas Can Increase the Efficiency of Ex Vivo Platelet Generation. Ann Hematol. 2012;91(11):1673-84.

Burkhardt W, Kraft S, Ochs M, Proquitte H, Mense L, Rudiger M. Persurf, a New Method to Improve Surfactant Delivery: A Study in Surfactant Depleted Rats. PLoS One. 2012;7(10):e47923.

Alten L, Schuster-Gossler K, Beckers A, Groos S, Ulmer B, Hegermann J, Ochs M, Gossler A. Differential Regulation of Node Formation, Nodal Ciliogenesis and Cilia Positioning by Noto and Foxj1. Development. 2012;139(7):1276-84.

Knudsen L, Boxler L, Muhlfeld C, Schaefer IM, Becker L, Bussinger C, von Stietencron I, Madershahian N, Richter J, Wahlers T, Wittwer T, Ochs M. Lung Preservation in Experimental Ischemia/Reperfusion Injury and Lung Transplantation: A Comparison of Natural and Synthetic Surfactants. J Heart Lung Transplant. 2012;31(1):85-93.

Unit 8.3 - Radionuclide Molecular Imaging

2016

Thackeray JT, Bengel FM. Specificity vs versatility: A fine balance for novel targeted molecular imaging radiotracers. J Nucl Cardiol. 2016.

Thackeray JT, Bengel FM. PET imaging of the autonomic nervous system. Q J Nucl Med Mol Imaging. 2016;60(4):362-82.

Thackeray JT, Bengel FM. Translational Molecular Nuclear Cardiology. Cardiol Clin. 2016;34(1):187-98.

Thackeray JT, Bankstahl JP, Wang Y, Wollert KC, Bengel FM. Targeting Amino Acid Metabolism for Molecular Imaging of Inflammation Early After Myocardial Infarction. Theranostics. 2016;6(11):1768-79.

Stapel B, Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JM, Roivainen A, Saraste A, Nickel AG, Saar JA, Sieve I, Pietzsch S, Muller M, Bogeski I, Kappl R, Jauhiainen M, Thackeray JT, Scherr M, Bengel FM, Hagl C, Tudorache I, Bauersachs J, Maack C, Hilfiker-Kleiner D. Low STAT3 expression sensitizes to toxic effects of beta-adrenergic receptor stimulation in peripartum cardiomyopathy. European heart journal. 2016.

Caobelli F, Wollenweber T, Bavendiek U, Kuhn C, Schutze C, Geworski L, Thackeray JT, Bauersachs J, Haverich A, Bengel FM. Simultaneous dual-isotope solid-state detector SPECT for improved tracking of white blood cells in suspected endocarditis. European heart journal. 2016.

Bengel FM. The Role of Attractiveness: Imaging the Interaction Between Cardiovascular and Immune System. J Nucl Med. 2016;57(7):1004-5.

Bengel FM. Imaging of Post-Infarct Inflammation: Moving Forward Toward Clinical Application. Circ Cardiovasc Imaging. 2016;9(4):e004713.

2015

Thackeray JT, Derlin T, Haghikia A, Napp LC, Wang Y, Ross TL, Schäfer A, Tillmanns J, Wester HJ, Wollert KC, Bauersachs J, Bengel FM. Molecular Imaging of the Chemokine Receptor Cxcr4 after Acute Myocardial Infarction. JACC: Cardiovascular Imaging. 2015.

Thackeray JT, Bankstahl JP, Wang Y, Wollert KC, Bengel FM. Clinically Relevant Strategies for Lowering Cardiomyocyte Glucose Uptake for 18f-Fdg Imaging of Myocardial Inflammation in Mice. Eur J Nucl Med Mol Imaging. 2015;42(5):771-80.

Thackeray JT, Bankstahl JP, Wang Y, Korf-Klingebiel M, Walte A, Wittneben A, Wollert KC, Bengel FM. Targeting Post-Infarct Inflammation by Pet Imaging: Comparison of Ga-68-Citrate and Ga-68-Dotatate with F-18-Fdg in a Mouse Model. European Journal of Nuclear Medicine and Molecular Imaging. 2015;42(2):317-27.

Thackeray JT, Bankstahl JP, Bengel FM. Impact of Image-Derived Input Function and Fit Time Intervals on Patlak Quantification of Myocardial Glucose Uptake in Mice. J Nucl Med. 2015;56(10):1615-21.

Li XG, Roivainen A, Bergman J, Heinonen A, Bengel F, Thum T, Knuuti J. Enabling [(18)F]-Bicyclo[6.1.0]Nonyne for Oligonucleotide Conjugation for Positron Emission Tomography Applications: [(18)F]-Anti-Microrna-21 as an Example. Chem Commun (Camb). 2015;51(48):9821-4.

Lautamaki R, Sasano T, Higuchi T, Nekolla SG, Lardo AC, Holt DP, Dannals RF, Abraham MR, Bengel FM. Multiparametric Molecular Imaging Provides Mechanistic Insights into Sympathetic Innervation Impairment in the Viable Infarct Border Zone. J Nucl Med. 2015;56(3):457-63. Epub 2015/01/31.

Derlin T, Janssen T, Salamon J, Veldhoen S, Busch JD, Schon G, Herrmann J, Henes FO, Bannas P, Adam G. Age-Related Differences in the Activity of Arterial Mineral Deposition and Regional Bone Metabolism: A 18f-Sodium Fluoride Positron Emission Tomography Study. Osteoporos Int. 2015;26(1):199-207.

Caobelli F, Bengel FM. Ischaemic Vs Non-Ischaemic Dilated Cardiomyopathy: The Value of Nuclear Cardiology Techniques. J Nucl Cardiol. 2015;22(5):971-4.

Caobelli F, Bengel FM. In Vivo Evaluation of Atherosclerotic Plaques and Culprit Lesions Using Noninvasive Techniques. Nat Rev Cardiol. 2015;12(2):79-.

Bravo PE, Lautamaki R, Carter D, Holt DP, Nekolla SG, Dannals RF, Russell SD, Bengel FM. Mechanistic Insights into Sympathetic Neuronal Regeneration: Multitracer Molecular Imaging of Catecholamine Handling after Cardiac Transplantation. Circ Cardiovasc Imaging. 2015;8(8):e003507. Epub 2015/08/08.

Derlin T, Alchalby H, Bannas P, Veldhoen S, Apostolova I, Triviai I, Bengel FM, Kroger N. Assessment of Bone Marrow Inflammation in Patients with Myelofibrosis: An 18f-Fluorodeoxyglucose Pet/Ct Study. Eur J Nucl Med Mol Imaging. 2015;42(5):696-705.

2014

Wollenweber T, Roentgen P, Schafer A, Schatka I, Zwadlo C, Brunkhorst T, Berding G, Bauersachs J, Bengel FM. Characterizing the Inflammatory Tissue Response to Acute Myocardial Infarction by Clinical Multimodality Noninvasive Imaging. Circ Cardiovasc Imaging. 2014;7(5):811-8.

Wollenweber T, Bengel FM. Cardiac Molecular Imaging. Semin Nucl Med. 2014;44(5):386-97.

Thackeray JT, deKemp RA, Beanlands RS, DaSilva JN. Early Diabetes Treatment Does Not Prevent Sympathetic Dysinnervation in the Streptozotocin Diabetic Rat Heart. J Nucl Cardiol. 2014;21(4):829-41. Epub 2014/06/04.

Stockhofe K, Postema JM, Schieferstein H, Ross TL. Radiolabeling of Nanoparticles and Polymers for Pet Imaging. Pharmaceuticals (Basel). 2014;7(4):392-418.

Schieferstein H, Kelsch A, Reibel A, Koynov K, Barz M, Buchholz HG, Bausbacher N, Thews O, Zentel R, Ross TL. 18f-Radiolabeling, Preliminary Evaluation of Folate-Phpma Conjugates Via Pet. Macromol Biosci. 2014;14(10):1396-405.

Schatka I, Bengel FM. Advanced Imaging of Cardiac Sarcoidosis. J Nucl Med. 2014;55(1):99-106.

Knuuti J, Bengel F, Bax JJ, Kaufmann PA, Le Guludec D, Perrone Filardi P, Marcassa C, Ajmone Marsan N, Achenbach S, Kitsiou A, Flotats A, Eeckhout E, Minn H, Hesse B. Risks and Benefits of Cardiac Imaging: An Analysis of Risks Related to Imaging for Coronary Artery Disease. Eur Heart J. 2014;35(10):633-8.

Happle C, Lachmann N, Skuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. Pulmonary Transplantation of Macrophage Progenitors as Effective and Long-Lasting Therapy for Hereditary Pulmonary Alveolar Proteinosis. Sci Transl Med. 2014;6(250):250ra113.

Bengel FM, Thackeray JT. Altered Cardiac Innervation Predisposes to Ventricular Arrhythmia: Targeted Positron Emission Tomography Identifies Risk in Ischemic Cardiomyopathy. J Am Coll Cardiol. 2014;63(2):150-2.

Bengel FM. The Non-Invasive Biopsy: Molecular Imaging for the Detection of Cardiac Involvement in Systemic Disease. Eur Heart J Cardiovasc Imaging. 2014;15(11):1299-300.

Bankstahl JP. What Does a Picture Tell? In Vivo Imaging of Abc Transporter Function. Drug Discov Today Technol. 2014;12:e113-9. Epub 2014/07/17.

2013

Thackeray JT, deKemp RA, Beanlands RS, DaSilva JN. Insulin Restores Myocardial Presynaptic Sympathetic Neuronal Integrity in Insulin-Resistant Diabetic Rats. J Nucl Cardiol. 2013;20(5):845-56.

Thackeray JT, Bengel FM. Assessment of Cardiac Autonomic Neuronal Function Using Pet Imaging. J Nucl Cardiol. 2013;20(1):150-65.

Schatka I, Wollenweber T, Haense C, Brunz F, Gratz KF, Bengel FM. Peptide Receptor-Targeted Radionuclide Therapy Alters Inflammation in Atherosclerotic Plaques. J Am Coll Cardiol. 2013;62(24):2344-5.

Janssen T, Bannas P, Herrmann J, Veldhoen S, Busch JD, Treszl A, Munster S, Mester J, Derlin T. Association of Linear (1)(8)F-Sodium Fluoride Accumulation in Femoral Arteries as a Measure of Diffuse Calcification with Cardiovascular Risk Factors: A Pet/Ct Study. J Nucl Cardiol. 2013;20(4):569-77. Epub 2013/04/17.

Higuchi T, Rischpler C, Fukushima K, Isoda T, Xia J, Javadi MS, Szabo Z, Dannals RF, Mathews WB, Bengel FM. Targeting of Endothelin Receptors in the Healthy and Infarcted Rat Heart Using the Pet Tracer 18f-Fbzbms. J Nucl Med. 2013;54(2):277-82.

Bengel FM, George RT, Schuleri KH, Lardo AC, Wollert KC. Image-Guided Therapies for Myocardial Repair: Concepts and Practical Implementation. Eur Heart J Cardiovasc Imaging. 2013;14(8):741-51.

2012

Fukushima K, Bravo PE, Higuchi T, Schuleri KH, Lin X, Abraham MR, Xia J, Mathews WB, Dannals RF, Lardo AC, Szabo Z, Bengel FM. Molecular Hybrid Positron Emission Tomography/Computed Tomography Imaging of Cardiac Angiotensin Ii Type 1 Receptors. J Am Coll Cardiol. 2012;60(24):2527-34.

Unit 8.4 - Small Animal MRI

2017

Rojas SV, Meier M, Zweigerdt R, Eckardt D, Rathert C, Schecker N, Schmitto JD, Rojas-Hernandez S, Martin U, Kutschka I, Haverich A, Martens A. Multimodal Imaging for In Vivo Evaluation of Induced Pluripotent Stem Cells in a Murine Model of Heart Failure. Artificial organs. 2017;41(2):192-9.

2016

Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Li W, Jang MS, Mengel M, Wacker F, Rong S, Gueler F. Kidney Transplantation: Multiparametric Functional Magnetic Resonance Imaging for Assessment of Renal Allograft Pathophysiology in Mice. Invest Radiol. 2016;51(1):58-65.

Hueper K, Gutberlet M, Brasen JH, Jang MS, Thorenz A, Chen R, Hertel B, Barrmeyer A, Schmidbauer M, Meier M, von Vietinghoff S, Khalifa A, Hartung D, Haller H, Wacker F, Rong S, Gueler F. Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice. PloS one. 2016;11(9):e0162705.

Breuer H, Meier M, Schneefeld S, Hartig W, Wittneben A, Markel M, Ross TL, Bengel FM, Bankstahl M, Bankstahl JP. Multimodality imaging of blood-brain barrier impairment during epileptogenesis. J Cereb Blood Flow Metab. 2016.

2015

Dreher W, Meier M. 1H NMR spectroscopy in inhomogeneous B0 fields using localized constant time spin echo correlation spectroscopy (L-CT-SECSY). Magnetic Resonance Materials in Physics, Biology and Medicine, October 2015, Volume 28, Issue 1, p 301, DOI: 10.1007/s10334-015-0489-0

Meier M, Haake D. Longitudinal measurement of tissue perfusion in a rat model of magnesium based implants using arterial spin labeling. Magnetic Resonance Materials in Physics, Biology and Medicine, October 2015, Volume 28, Issue 1, p 369, DOI: 10.1007/s10334-015-0489-0

Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Li W, Jang MS, Mengel M, Wacker F, Rong S, Gueler F. Kidney Transplantation: Multiparametric Functional Magnetic Resonance Imaging for Assessment of Renal Allograft Pathophysiology in Mice. Invest Radiol. 2015. Epub 2015/09/16.

Chatterji B, Dickhut C, Mielke S, Kruger J, Just I, Glage S, Meier M, Wedekind D, Pich A. Maldi Imaging Mass Spectrometry to Investigate Endogenous Peptides in an Animal Model of Usher's Disease. Proteomics. 2014;14(13-14):1674-87.

Guseva D, Holst K, Kaune B, Meier M, Keubler L, Glage S, Buettner M, Bleich A, Pabst O, Bachmann O, Ponimaskin EG. Serotonin 5-Ht7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract. Inflamm Bowel Dis. 2014;20(9):1516-29. Epub 2014/07/30.

Hueper K, Gutberlet M, Rong S, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice-Comparison with Histopathologic Results and Renal Function. Radiology. 2014;270(1):117-24.

Hueper K, Peperhove M, Rong S, Gerstenberg J, Mengel M, Meier M, Gutberlet M, Tewes S, Barrmeyer A, Chen R, Haller H, Wacker F, Hartung D, Gueler F. T1-Mapping for Assessment of Ischemia-Induced Acute Kidney Injury and Prediction of Chronic Kidney Disease in Mice. Eur Radiol. 2014;24(9):2252-60.

Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F. Renal Pkc-Epsilon Deficiency Attenuates Acute Kidney Injury and Ischemic Allograft Injury Via Tnf-Alpha-Dependent Inhibition of Apoptosis and Inflammation. Am J Physiol Renal Physiol. 2014;307(6):F718-26. Epub 2014/07/25.

2014

Hueper K, Gutberlet M, Rong S, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice-Comparison with Histopathologic Results and Renal Function. Radiology. 2014;270(1):117-24.

Chatterji B, Dickhut C, Mielke S, Kruger J, Just I, Glage S, Meier M, Wedekind D, Pich A. Maldi Imaging Mass Spectrometry to Investigate Endogenous Peptides in an Animal Model of Usher's Disease. Proteomics. 2014;14(13-14):1674-87.

Rong S, Hueper K, Kirsch T, Greite R, Klemann C, Mengel M, Meier M, Menne J, Leitges M, Susnik N, Meier M, Haller H, Shushakova N, Gueler F. Renal Pkc-Epsilon Deficiency Attenuates Acute Kidney Injury and Ischemic Allograft Injury Via Tnf-Alpha-Dependent Inhibition of Apoptosis and Inflammation. Am J Physiol Renal Physiol. 2014;307(6):F718-26.

Guseva D, Holst K, Kaune B, Meier M, Keubler L, Glage S, Buettner M, Bleich A, Pabst O, Bachmann O, Ponimaskin EG. Serotonin 5-Ht7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract. Inflamm Bowel Dis. 2014;20(9):1516-29.

Hueper K, Peperhove M, Rong S, Gerstenberg J, Mengel M, Meier M, Gutberlet M, Tewes S, Barrmeyer A, Chen R, Haller H, Wacker F, Hartung D, Gueler F. T1-Mapping for Assessment of Ischemia-Induced Acute Kidney Injury and Prediction of Chronic Kidney Disease in Mice. Eur Radiol. 2014;24(9):2252-60.

2013

Michael S, Keubler LM, Smoczek A, Meier M, Gunzer F, Pohlmann C, Krause-Buchholz U, Hedrich HJ, Bleich A. Quantitative Phenotyping of Inflammatory Bowel Disease in the Il-10-Deficient Mouse by Use of Noninvasive Magnetic Resonance Imaging. Inflamm Bowel Dis. 2013;19(1):185-93.

Hueper K, Rong S, Gutberlet M, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. T2 Relaxation Time and Apparent Diffusion Coefficient for Noninvasive Assessment of Renal Pathology after Acute Kidney Injury in Mice: Comparison with Histopathology. Invest Radiol. 2013;48(12):834-42.

2012

Lu X, Li N, Shushakova N, Schmitt R, Menne J, Susnik N, Meier M, Leitges M, Haller H, Gueler F, Rong S. C57bl/6 and 129/Sv Mice: Genetic Difference to Renal Ischemia-Reperfusion. J Nephrol. 2012;25(5):738-43.

Willenbrock S, Knippenberg S, Meier M, Hass R, Wefstaedt P, Nolte I, Murua Escobar H, Petri S. In Vivo Mri of Intraspinally Injected Spio-Labelled Human Cd34+ Cells in a Transgenic Mouse Model of Als. In Vivo. 2012;26(1):31-8.

Sterenczak KA, Meier M, Glage S, Meyer M, Willenbrock S, Wefstaedt P, Dorsch M, Bullerdiek J, Murua Escobar H, Hedrich H, Nolte I. Longitudinal Mri Contrast Enhanced Monitoring of Early Tumour Development with Manganese Chloride (Mncl2) and Superparamagnetic Iron Oxide Nanoparticles (Spios) in a Ct1258 Based in Vivo Model of Prostate Cancer. BMC Cancer. 2012;12:284.

Baraki H, Zinne N, Wedekind D, Meier M, Bleich A, Glage S, Hedrich HJ, Kutschka I, Haverich A. Magnetic Resonance Imaging of Soft Tissue Infection with Iron Oxide Labeled Granulocytes in a Rat Model. PLoS One. 2012;7(12):e51770.

Sommer T, Meier M, Bruns F, Pabst R, Breves G, Hadamitzky C. Quantification of Lymphedema in a Rat Model by 3d-Active Contour Segmentation by Magnetic Resonance Imaging. Lymphat Res Biol. 2012;10(1):25-9.

Witte F, Kalla K, Meier M. Magnesium corrosion associated gas cavity formation imaged in vivo using MRI. Annual Meeting of the Swiss Society for Biomaterials. Eur Cell and Mater. 2012(23)Suppl. 2, 2012

Froese N, Kattih B, Grund A, Meier M, Hilfiker-Kleiner D, Bauersachs J, Heineke J. P1671 - Protektive Effekte des endothelialen Transkriptionsfaktors GATA2 auf das Myokard nach pathologischer Druckbelastung. Kreislaufforschung DGfK-H-u. 78. Jahrestagung der Deutsche Gesellschaft für Kardiologie- Herz- und Kreislaufforschung vom 11. bis 14. April 2012 in Mannheim. Clin Res Cardiol. 2012;101(0):1.

Saghafia M, Limbourg A, Korf-Klingebiel M, Woiterski J, Meier M, Wollert KC, Limbourg F. P1681 - A vascular cause of dilated cardiomyopathy? Control of cardiac homeostasis and function by microvascular Notch signalling. Kreislaufforschung DGfK-H-u. 78. Jahrestagung der Deutsche Gesellschaft für Kardiologie- Herz- und Kreislaufforschung vom 11. bis 14. April 2012 in Mannheim. Clin Res Cardiol. 2012;101(0):1.

2011

Bankstahl JP, Bankstahl M, Kuntner C, Stanek J, Wanek T, Meier M, Ding XQ, Muller M, Langer O, Loscher W. A Novel Positron Emission Tomography Imaging Protocol Identifies Seizure-Induced Regional Overactivity of P-Glycoprotein at the Blood-Brain Barrier. J Neurosci. 2011;31(24):8803-11.

2010

Kuntner C, Bankstahl JP, Bankstahl M, Stanek J, Wanek T, Stundner G, Karch R, Brauner R, Meier M, Ding X, Muller M, Loscher W, Langer O. Dose-Response Assessment of Tariquidar and Elacridar and Regional Quantification of P-Glycoprotein Inhibition at the Rat Blood-Brain Barrier Using (R)-[(11)C]Verapamil Pet. Eur J Nucl Med Mol Imaging. 2010;37(5):942-53.

2008

Meier M. Artifacts or Art in Fact: Useful susceptibility effects in MRI. In: Biomagnetism: Interdisciplinary Research and Exploration, Suppl. Kakigi R, Yokosawa K, Kuriki S. (Eds.), Hokkaido University Press, 2008, ISBN 978-4-8329-0355-5.

2007

Dreher W, Meier M, Erhard P, Leibfritz D. On the use of spin echo and stimulated echo based functional MRI sequences. In: Topics in Advanced Imaging. Herrmann M, Thiel C. (Eds.), Oldenburg, 2007, 51-4. ISBN: 978-3

Unit 8.5 - Funtional and Molecular MRI

2016

Voskrebenzev A, Gutberlet M, Kaireit TF, Wacker F, Vogel-Claussen J. Low-pass imaging of dynamic acquisitions (LIDA) with a group-oriented registration (GOREG) for proton MR imaging of lung ventilation. Magn Reson Med. 2016.

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Hoffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016;49(4):1228-38.

Hueper K, Khalifa AA, Brasen JH, Vo Chieu VD, Gutberlet M, Wintterle S, Lehner F, Richter N, Peperhove M, Tewes S, Weber K, Haller H, Wacker F, Gwinner W, Gueler F, Hartung D. Diffusion-Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation. J Magn Reson Imaging. 2016;44(1):112-21.

Hueper K, Gutberlet M, Brasen JH, Jang MS, Thorenz A, Chen R, Hertel B, Barrmeyer A, Schmidbauer M, Meier M, von Vietinghoff S, Khalifa A, Hartung D, Haller H, Wacker F, Rong S, Gueler F. Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice. PloS one. 2016;11(9):e0162705.

2015

Renne J, Lauermann P, Hinrichs J, Schonfeld C, Sorrentino S, Gutberlet M, Jakob P, Wacker F, Vogel-Claussen J. Clinical Use of Oxygen-Enhanced T1 Mapping Mri of the Lung: Reproducibility and Impact of Closed Versus Loose Fit Oxygen Delivery System. J Magn Reson Imaging. 2015;41(1):60-6. Epub 2013/12/18.

Renne J, Hinrichs J, Schonfeld C, Gutberlet M, Winkler C, Faulenbach C, Jakob P, Schaumann F, Krug N, Wacker F, Hohlfeld JM, Vogel-Claussen J. Noninvasive Quantification of Airway Inflammation Following Segmental Allergen Challenge with Functional Mr Imaging: A Proof of Concept Study. Radiology. 2015;274(1):267-75.

Schonfeld C, Cebotari S, Voskrebenzev A, Gutberlet M, Hinrichs J, Renne J, Hoeper MM, Olsson KM, Welte T, Wacker F, Vogel-Claussen J. Performance of Perfusion-Weighted Fourier Decomposition Mri for Detection of Chronic Pulmonary Emboli. J Magn Reson Imaging. 2015;42(1):72-9.

Hueper K, Gueler F, Brasen JH, Gutberlet M, Jang MS, Lehner F, Richter N, Hanke N, Peperhove M, Martirosian P, Tewes S, Vo Chieu VD, Grosshennig A, Haller H, Wacker F, Gwinner W, Hartung D. Functional Mri Detects Perfusion Impairment in Renal Allografts with Delayed Graft Function. Am J Physiol Renal Physiol. 2015;308(12):F1444-51.

Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Li W, Jang MS, Mengel M, Wacker F, Rong S, Gueler F. Kidney Transplantation: Multiparametric Functional Magnetic Resonance Imaging for Assessment of Renal Allograft Pathophysiology in Mice. Invest Radiol. 2015.

Renne J, Lauermann P, Hinrichs JB, Schonfeld C, Sorrentino S, Gutberlet M, Jakob P, Haverich A, Warnecke G, Welte T, Wacker FK, Gottlieb J, Vogel-Claussen J. Chronic Lung Allograft Dysfunction: Oxygen-Enhanced T1-Mapping Mr Imaging of the Lung. Radiology. 2015;276(1):266-73.

Solyanik O, Hollmann P, Dettmer S, Kaireit T, Schaefer-Prokop C, Wacker F, Vogel-Claussen J, Shin HO. Quantification of Pathologic Air Trapping in Lung Transplant Patients Using Ct Density Mapping: Comparison with Other Ct Air Trapping Measures. PLoS One. 2015;10(10):e0139102. Epub 2015/10/03.

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Hoffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized Aortic Allografts Versus Pulmonary Autografts for Aortic Valve Replacement in the Growing Sheep Model: Haemodynamic and Morphological Results at 20 Months after Implantation. Eur J Cardiothorac Surg. 2015. Epub 2015/10/28.

2014

Hinrichs JB, Renne J, Schoenfeld C, Gutberlet M, Haverich A, Warnecke G, Welte T, Wacker F, Gottlieb J, Vogel-Claussen J. Cardiac Mass and Function Decrease in Bronchiolitis Obliterans Syndrome after Lung Transplantation: Relationship to Physical Activity? PLoS One. 2014;9(12):e114001.

Hueper K, Gutberlet M, Rong S, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice-Comparison with Histopathologic Results and Renal Function. Radiology. 2014;270(1):117-24.

Dettmer S, Peters L, de Wall C, Schaefer-Prokop C, Schmidt M, Warnecke G, Gottlieb J, Wacker F, Shin HO. Bronchial Wall Measurements in Patients after Lung Transplantation: Evaluation of the Diagnostic Value for the Diagnosis of Bronchiolitis Obliterans Syndrome. PLoS One. 2014;9(4):e93783.

Bauer M, Schilling T, Weidling M, Hartung D, Biskup C, Wriggers P, Wacker F, Bach FW, Haverich A, Hassel T. Geometric Adaption of Biodegradable Magnesium Alloy Scaffolds to Stabilise Biological Myocardial Grafts. Part I. J Mater Sci Mater Med. 2014;25(3):909-16.

Shehata ML, Basha TA, Hayeri MR, Hartung D, Teytelboym OM, Vogel-Claussen J. Mr Myocardial Perfusion Imaging: Insights on Techniques, Analysis, Interpretation, and Findings. Radiographics. 2014;34(6):1636-57.

Hinrichs J, Schaumann F, Renne J, Schonfeld C, Faulenbach C, Winkler C, Gutberlet M, Krug N, Wacker F, Hohlfeld JM, Vogel-Claussen J. Phase-Contrast Mri for Detection of Mild Systemic Hemodynamic Response after Segmental Allergen Challenge in Asthmatic Patients. Acad Radiol. 2014;21(8):994-1001. Epub 2014/07/16.

Vogel-Claussen J, Renne J, Hinrichs J, Schonfeld C, Gutberlet M, Schaumann F, Winkler C, Faulenbach C, Krug N, Wacker FK, Hohlfeld JM. Quantification of Pulmonary Inflammation after Segmental Allergen Challenge Using Turbo-Inversion Recovery-Magnitude Magnetic Resonance Imaging. Am J Respir Crit Care Med. 2014;189(6):650-7.

Hueper K, Peperhove M, Rong S, Gerstenberg J, Mengel M, Meier M, Gutberlet M, Tewes S, Barrmeyer A, Chen R, Haller H, Wacker F, Hartung D, Gueler F. T1-Mapping for Assessment of Ischemia-Induced Acute Kidney Injury and Prediction of Chronic Kidney Disease in Mice. Eur Radiol. 2014;24(9):2252-60.

2013

Hueper K, Hartung D, Gutberlet M, Gueler F, Sann H, Husen B, Wacker F, Reiche D. Assessment of Impaired Vascular Reactivity in a Rat Model of Diabetic Nephropathy: Effect of Nitric Oxide Synthesis Inhibition on Intrarenal Diffusion and Oxygenation Measured by Magnetic Resonance Imaging. Am J Physiol Renal Physiol. 2013;305(10):F1428-35.

Tudorache I, Calistru A, Baraki H, Meyer T, Hoffler K, Sarikouch S, Bara C, Gorler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic Replacement of Aortic Heart Valves with Tissue-Engineered Grafts. Tissue Eng Part A. 2013;19(15-16):1686-94.

Hueper K, Parikh M, Prince MR, Schoenfeld C, Liu C, Bluemke DA, Dashnaw SM, Goldstein TA, Hoffman E, Lima JA, Skrok J, Zheng J, Barr RG, Vogel-Claussen J. Quantitative and Semi-Quantitative Measures of Regional Pulmonary Parenchymal Perfusion by Magnetic Resonance Imaging and Their Relationships to Global Lung Perfusion and Lung Diffusing Capacity – the Mesa Copd Study. Investigative radiology. 2013;48(4):223-30.

Hueper K, Rong S, Gutberlet M, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. T2 Relaxation Time and Apparent Diffusion Coefficient for Noninvasive Assessment of Renal Pathology after Acute Kidney Injury in Mice: Comparison with Histopathology. Invest Radiol. 2013;48(12):834-42.

Kedziorek DA, Solaiyappan M, Walczak P, Ehtiati T, Fu Y, Bulte JWM, Shea SM, Brost A, Wacker FK, Kraitchman DL. Using C-Arm X-Ray Imaging to Guide Local Reporter Probe Delivery for Tracking Stem Cell Engraftment. Theranostics. 2013;3(11):916-26.

2013

Dettmer S, Entrup J, Schmidt M, de Wall C, Wacker F, Shin H. Bronchial Wall Thickness Measurement in Computed Tomography: Effect of Intravenous Contrast Agent and Reconstruction Kernel. Eur J Radiol. 2012;81(11):3606-13.

Bauer M, Hassel T, Biskup C, Hartung D, Schilling T, Weidling M, Wriggers P, Wacker F, Bach Fr W, Haverich A. Geometric Adaption of Resorbable Myocardial Stabilizing Structures Based on the Magnesium Alloys La63 and Zek100 for the Support of Myocardial Grafts on the Left Ventricle. Biomedical Engineering / Biomedizinische Technik2012. p. 22.

Hueper K, Hartung D, Gutberlet M, Gueler F, Sann H, Husen B, Wacker F, Reiche D. Magnetic Resonance Diffusion Tensor Imaging for Evaluation of Histopathological Changes in a Rat Model of Diabetic Nephropathy. Invest Radiol. 2012;47(7):430-7. Epub 2012/06/05.

Hueper K, Zapf A, Skrok J, Pinheiro AC, Goldstein TA, Zheng J, Zimmerman SL, Kamel IR, Abraham MR, Wacker F, Bluemke DA, Abraham T, Vogel-Claussen J. Reduction of Relative Resting Myocardial Blood Flow Is Related to Myocardial Delayed Enhancement, T2-Signal Abnormalities, Left-Ventricular Wall Thickness and Age in Patients with Hypertrophic Cardiomyopathy. Journal of Cardiovascular Magnetic Resonance. 2012;14(Suppl 1):P158-P.

2011

Hueper K, Gutberlet M, Rodt T, Gwinner W, Lehner F, Wacker F, Galanski M, Hartung D. Diffusion Tensor Imaging and Tractography for Assessment of Renal Allograft Dysfunction-Initial Results. Eur Radiol. 2011;21(11):2427-33.

Unit 8.6 - Computational Image Analysis

2016

Wandt B, Ackermann H, Rosenhahn B. 3D Reconstruction of Human Motion from Monocular Image Sequences. IEEE Trans Pattern Anal Mach Intell. 2016;38(8):1505-16.

von Marcard T, Pons-Moll G, Rosenhahn B. Human Pose Estimation from Video and IMUs. IEEE Trans Pattern Anal Mach Intell. 2016.

Schlobohm J, Pösch A, Reithmeier E, Rosenhahn B. Improving contour based pose estimation for fast 3D measurement of free form objects. Measurement. 2016;92:79-82.

Perez-Pellitero E, Salvador J, Ruiz-Hidalgo J, Rosenhahn B. Antipodally Invariant Metrics for Fast Regression-Based Super-Resolution. IEEE Trans Image Process. 2016;25(6):2456-68.

2015

Zell P, Rosenhahn B. A Physics-Based Statistical Model for Human Gait Analysis. In: Gall J, Gehler P, Leibe B, editors. Pattern Recognition: 37th German Conference, GCPR 2015, Aachen, Germany, October 7-10, 2015, Proceedings. Cham: Springer International Publishing; 2015. p. 169-80.

Salman Al-Shaikhli SD, Yang MY, Rosenhahn B. 3d Automatic Liver Segmentation Using Feature-Constrained Mahalanobis Distance in Ct Images. Biomed Tech (Berl). 2015. Epub 2015/10/27.

Salman Al-Shaikhli Saif D, Yang Michael Y, Rosenhahn B. Brain Tumor Classification and Segmentation Using Sparse Coding and Dictionary Learning. Biomedical Engineering / Biomedizinische Technik2015.

Salman Al-shaikhli Saif D, Yang Michael Y, Rosenhahn B. 3d Automatic Liver Segmentation Using Feature-Constrained Mahalanobis Distance in Ct Images. Biomedical Engineering / Biomedizinische Technik2015.

Kuznetsova A, Sung Ju H, Rosenhahn B, Sigal L, editors. Expanding Object Detector's Horizon: Incremental Learning Framework for Object Detection in Videos. Computer Vision and Pattern Recognition (CVPR), 2015 IEEE Conference on; 2015 7-12 June 2015.

2014

Shoaib M, Yang MY, Rosenhahn B, Ostermann J. Estimating Layout of Cluttered Indoor Scenes Using Trajectory-Based Priors. Image and Vision Computing. 2014;32(11):870-83.

Henseler H, Kuznetsova A, Vogt P, Rosenhahn B. Validation of the Kinect Device as a New Portable Imaging System for Three-Dimensional Breast Assessment. J Plast Reconstr Aesthet Surg. 2014;67(4):483-8.

Bartsch I, Willbold E, Rosenhahn B, Witte F. Non-Invasive Ph Determination Adjacent to Degradable Biomaterials in Vivo. Acta Biomater. 2014;10(1):34-9.

Al-Shaikhli SD, Yang MY, Rosenhahn B. Multi-Region Labeling and Segmentation Using a Graph Topology Prior and Atlas Information in Brain Images. Comput Med Imaging Graph. 2014;38(8):725-34.

2013

Kuznetsova A, Leal-Taixé L, Rosenhahn B. Real-time sign language recognition using a consumer depth camera. IEEE International Conference on Computer Vision Workshops (ICCVW), 3rd Workshop on Consumer Depth Cameras for Computer Vision (CDC4CV), December 2013.

Scheuermann B, Gkoutelitsas S, Rosenhahn B. Multi-Sensor Fusion Using Dempster’s Theory of Evidence for Video Segmentation. In: Ruiz-Shulcloper J, Sanniti di Baja G, editors. Progress in Pattern Recognition, Image Analysis, Computer Vision, and Applications: Springer Berlin Heidelberg; 2013. p. 431-8.

Muller O, Yang MY, Rosenhahn B, editors. Slice Sampling Particle Belief Propagation. Computer Vision (ICCV), 2013 IEEE International Conference on; 2013 1-8 Dec. 2013.

Donner S, Muller O, Witte F, Bartsch I, Willbold E, Ripken T, Heisterkamp A, Rosenhahn B, Kruger A. In Situ Optical Coherence Tomography of Percutaneous Implant-Tissue Interfaces in a Murine Model. Biomed Tech (Berl). 2013;58(4):359-67.

2012

Spindler R, Rosenhahn B, Hofmann N, Glasmacher B. Video Analysis of Osmotic Cell Response During Cryopreservation. Cryobiology. 2012;64(3):250-60.

Muller O, Donner S, Klinder T, Bartsch I, Kruger A, Heisterkamp A, Rosenhahn B. Compensating Motion Artifacts of 3d in Vivo Sd-Oct Scans. Med Image Comput Comput Assist Interv. 2012;15(Pt 1):198-205.

Kuznetsova A, Pons-Moll G, Rosenhahn B. Pca-Enhanced Stochastic Optimization Methods. In: Pinz A, Pock T, Bischof H, Leberl F, editors. Pattern Recognition: Springer Berlin Heidelberg; 2012. p. 377-86.

2011

Muller O, Donner S, Klinder T, Dragon R, Bartsch I, Witte F, Kruger A, Heisterkamp A, Rosenhahn B. Model Based 3d Segmentation and Oct Image Undistortion of Percutaneous Implants. Med Image Comput Comput Assist Interv. 2011;14(Pt 3):454-62.

Ehlers A, Baumann F, Spindler R, Glasmacher B, Rosenhahn B. Pca Enhanced Training Data for Adaboost. In: Real P, Diaz-Pernil D, Molina-Abril H, Berciano A, Kropatsch W, editors. Computer Analysis of Images and Patterns: Springer Berlin Heidelberg; 2011. p. 410-9.

Helga H, Kim BS, Peter Maria V, Bodo R. The Kinect Recording System for Objective Three- and Four-Dimensional Breast Assessment with Image Overlays. Journal of Plastic, Reconstructive & Aesthetic Surgery.

Al-Shaikhli SDS, Yang MY, Rosenhahn B. Multi-Region Labeling and Segmentation Using a Graph Topology Prior and Atlas Information in Brain Images. Computerized Medical Imaging and Graphics.38(8):725-34.

Unit 8.7 - Functional Molecular Microscopy

2016

Timashev PS, Vedunova MV, Guseva D, Ponimaskin E, Deiwick A, Mishchenko TA, Mitroshina EV, Koroleva AV, Pimashkin AS, Mukhina IV, Panchenko VY, Chichkov BN, Bagratashvili VN. 3D in vitro platform produced by two-photon polymerization for the analysis of neural network formation and function. Biomedical Physics & Engineering Express. 2016;2(3):035001.

Lievens PM, Kuznetsova T, Kochlamazashvili G, Cesca F, Gorinski N, Galil DA, Cherkas V, Ronkina N, Lafera J, Gaestel M, Ponimaskin E, Dityatev A. ZDHHC3 Tyrosine Phosphorylation Regulates Neural Cell Adhesion Molecule Palmitoylation. Mol Cell Biol. 2016;36(17):2208-25.

Hartmann D, Fiedler J, Sonnenschein K, Just A, Pfanne A, Zimmer K, Remke J, Foinquinos A, Butzlaff M, Schimmel K, Maegdefessel L, Hilfiker-Kleiner D, Lachmann N, Schober A, Froese N, Heineke J, Bauersachs J, Batkai S, Thum T. MicroRNA-Based Therapy of GATA2-Deficient Vascular Disease. Circulation. 2016;134(24):1973-90.

2015

Steinke KV, Gorinski N, Wojciechowski D, Todorov V, Guseva D, Ponimaskin E, Fahlke C, Fischer M. Human Clc-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional. J Biol Chem. 2015;290(28):17390-400. Epub 2015/05/28.

Holst K, Guseva D, Schindler S, Sixt M, Braun A, Chopra H, Pabst O, Ponimaskin E. The Serotonin Receptor 5-Ht(7)R Regulates the Morphology and Migratory Properties of Dendritic Cells. J Cell Sci. 2015;128(15):2866-80. Epub 2015/06/21.

Butzlaff M, Weigel A, Ponimaskin E, Zeug A. Esip: A Novel Solution-Based Sectioned Image Property Approach for Microscope Calibration. PLoS One. 2015;10(8):e0134980.

Butzlaff M, Hannan SB, Karsten P, Lenz S, Ng J, Vossfeldt H, Prussing K, Pflanz R, Schulz JB, Rasse T, Voigt A. Impaired Retrograde Transport by the Dynein/Dynactin Complex Contributes to Tau-Induced Toxicity. Hum Mol Genet. 2015;24(13):3623-37.

Bazovkina DV, Kondaurova EM, Naumenko VS, Ponimaskin E. Genotype-Dependent Difference in 5-Ht2c Receptor-Induced Hypolocomotion: Comparison with 5-Ht2a Receptor Functional Activity. Neural Plast. 2015;2015:846589.

2014

Zeug A, Stawarski M, Bieganska K, Korotchenko S, Wlodarczyk J, Dityatev A, Ponimaskin E. Current Microscopic Methods for the Neural Ecm Analysis. Prog Brain Res. 2014;214:287-312.

Stawarski M, Rutkowska-Wlodarczyk I, Zeug A, Bijata M, Madej H, Kaczmarek L, Wlodarczyk J. Genetically Encoded Fret-Based Biosensor for Imaging Mmp-9 Activity. Biomaterials. 2014;35(5):1402-10.

Skupien A, Konopka A, Trzaskoma P, Labus J, Gorlewicz A, Swiech L, Babraj M, Dolezyczek H, Figiel I, Ponimaskin E, Wlodarczyk J, Jaworski J, Wilczynski GM, Dzwonek J. Cd44 Regulates Dendrite Morphogenesis through Src Tyrosine Kinase-Dependent Positioning of the Golgi. J Cell Sci. 2014;127(23):5038-51.

Naumenko VS, Popova NK, Lacivita E, Leopoldo M, Ponimaskin EG. Interplay between Serotonin 5-Ht1a and 5-Ht7 Receptors in Depressive Disorders. CNS Neurosci Ther. 2014;20(7):582-90.

Guseva D, Wirth A, Ponimaskin E. Cellular Mechanisms of the 5-Ht7 Receptor-Mediated Signaling. Front Behav Neurosci. 2014;8:306.

Guseva D, Holst K, Kaune B, Meier M, Keubler L, Glage S, Buettner M, Bleich A, Pabst O, Bachmann O, Ponimaskin EG. Serotonin 5-Ht7 Receptor Is Critically Involved in Acute and Chronic Inflammation of the Gastrointestinal Tract. Inflamm Bowel Dis. 2014;20(9):1516-29.

Glebov K, Voronezhskaya EE, Khabarova MY, Ivashkin E, Nezlin LP, Ponimaskin EG. Mechanisms Underlying Dual Effects of Serotonin During Development of Helisoma Trivolvis (Mollusca). BMC Dev Biol. 2014;14:14.

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bahre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Muller R, Lochner M, Sparwasser T. De Novo Fatty Acid Synthesis Controls the Fate between Regulatory T and T Helper 17 Cells. Nat Med. 2014;20(11):1327-33.

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J, Thum T. Cardiac Fibroblast-Derived Microrna Passenger Strand-Enriched Exosomes Mediate Cardiomyocyte Hypertrophy. J Clin Invest. 2014;124(5):2136-46.

2013

Wirth A, Chen-Wacker C, Wu YW, Gorinski N, Filippov MA, Pandey G, Ponimaskin E. Dual Lipidation of the Brain-Specific Cdc42 Isoform Regulates Its Functional Properties. Biochem J. 2013;456(3):311-22.

Prasad S, Zeug A, Ponimaskin E. Analysis of Receptor-Receptor Interaction by Combined Application of Fret and Microscopy. Methods Cell Biol. 2013;117:243-65.

Gorinski N, Ponimaskin E. Palmitoylation of Serotonin Receptors. Biochem Soc Trans. 2013;41(1):89-94.

2012

Zeug A, Woehler A, Neher E, Ponimaskin EG. Quantitative Intensity-Based Fret Approaches--a Comparative Snapshot. Biophys J. 2012;103(9):1821-7.

Renner U, Zeug A, Woehler A, Niebert M, Dityatev A, Dityateva G, Gorinski N, Guseva D, Abdel-Galil D, Frohlich M, Doring F, Wischmeyer E, Richter DW, Neher E, Ponimaskin EG. Heterodimerization of Serotonin Receptors 5-Ht1a and 5-Ht7 Differentially Regulates Receptor Signalling and Trafficking. J Cell Sci. 2012;125(Pt 10):2486-99.

Kobe F, Guseva D, Jensen TP, Wirth A, Renner U, Hess D, Muller M, Medrihan L, Zhang W, Zhang M, Braun K, Westerholz S, Herzog A, Radyushkin K, El-Kordi A, Ehrenreich H, Richter DW, Rusakov DA, Ponimaskin E. 5-Ht7r/G12 Signaling Regulates Neuronal Morphology and Function in an Age-Dependent Manner. J Neurosci. 2012;32(9):2915-30.

Unit 9.1 - Large Animal Models

2016

Ramm R, Niemann H, Petersen B, Haverich A, Hilfiker A. Decellularized GGTA1-KO pig heart valves do not bind preformed human xenoantibodies. Basic research in cardiology. 2016;111(4):39.

Petkov S, Glage S, Nowak-Imialek M, Niemann H. Long-Term Culture of Porcine Induced Pluripotent Stem-Like Cells Under Feeder-Free Conditions in the Presence of Histone Deacetylase Inhibitors. Stem Cells Dev. 2016;25(5):386-94.

Garrels W, Mukherjee A, Holler S, Cleve N, Talluri TR, Barg-Kues B, Diederich M, Kohler P, Petersen B, Lucas-Hahn A, Niemann H, Izsvak Z, Ivics Z, Kues WA. Identification and re-addressing of a transcriptionally permissive locus in the porcine genome. Transgenic Res. 2016;25(1):63-70.

Fischer K, Kraner-Scheiber S, Petersen B, Rieblinger B, Buermann A, Flisikowska T, Flisikowski K, Christan S, Edlinger M, Baars W, Kurome M, Zakhartchenko V, Kessler B, Plotzki E, Szczerbal I, Switonski M, Denner J, Wolf E, Schwinzer R, Niemann H, Kind A, Schnieke A. Efficient production of multi-modified pigs for xenotransplantation by 'combineering', gene stacking and gene editing. Scientific reports. 2016;6:29081.

2015

Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model. Journal of the American College of Cardiology. 2015;66(2):154-65.

Petersen B, Niemann H. The future of transgenic farm animal production with emphasis on pigs. CAB Reviews 9, Nr. 44, 1-16. 2015.

Petersen B, Niemann H. Advances in Genetic Modification of Farm Animals Using Zinc-Finger Nucleases (Zfn). Chromosome Res. 2015;23(1):7-15. Epub 2015/01/19.

Denner J, Petersen B, Niemann H. Tolerance and Immune Response to the Porcine Endogenous Retrovirus in German Landrace Pigs Immunised with Viral Proteins. Virus Res. 2015;208:39-43. Epub 2015/06/06.

Ahrens HE, Petersen B, Ramackers W, Petkov S, Herrmann D, Hauschild-Quintern J, Lucas-Hahn A, Hassel P, Ziegler M, Baars W, Bergmann S, Schwinzer R, Winkler M, Niemann H. Kidneys from Α1,3-Galactosyltransferase Knockout/Human Heme Oxygenase-1/Human A20 Transgenic Pigs Are Protected from Rejection During Ex Vivo Perfusion with Human Blood. Transplantation Direct. 2015;1(6):1-8.

Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 Gene Therapy Provides Cardioprotection Via Control of Post-Ischemic Inflammation: An Experimental Study in a Pre-Clinical Pig Model. J Am Coll Cardiol. 2015;66(2):154-65. Epub 2015/07/15.

Ahrens HE, Petersen B, Herrmann D, Lucas-Hahn A, Hassel P, Ziegler M, Kues WA, Baulain U, Baars W, Schwinzer R, Denner J, Rataj D, Werwitzke S, Tiede A, Bongoni AK, Garimella PS, Despont A, Rieben R, Niemann H. Sirna Mediated Knockdown of Tissue Factor Expression in Pigs for Xenotransplantation. Am J Transplant. 2015;15(5):1407-14.

Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Niemann H, Kues WA. Derivation and Characterization of Bovine Induced Pluripotent Stem Cells by Transposon-Mediated Reprogramming. Cell Reprogram. 2015;17(2):131-40.

Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tonjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of Porcine Islet Cells as a Potential Option for the Treatment of Type 1 Diabetes in the Future. Horm Metab Res. 2015;47(1):31-5. Epub 2014/12/17.

Petersen B, Niemann H. Molecular Scissors and Their Application in Genetically Modified Farm Animals. Transgenic Res. 2015;24(3):381-96. Epub 2015/01/22.

Heinzmann J, Mattern F, Aldag P, Bernal-Ulloa SM, Schneider T, Haaf T, Niemann H. Extended in Vitro Maturation Affects Gene Expression and DNA Methylation in Bovine Oocytes. Mol Hum Reprod. 2015;21(10):770-82.

2014

Keller M, Petersen B, Niemann H, Denner J. Lack of antibody response in pigs immunised with the transmembrane envelope protein of porcine endogenous retroviruses (PERV). J Gen. 2014. Virol 95, 1827-1831.

Garrels W, Holler S, Taylor U, Herrmann D, Niemann H, Ivics Z, Kues WA. Assessment of Fetal Cell Chimerism in Transgenic Pig Lines Generated by Sleeping Beauty Transposition. PLoS One. 2014;9(5):e96673.

Amrute-Nayak M, Lambeck KA, Radocaj A, Huhnt HE, Scholz T, Hahn N, Tsiavaliaris G, Walter WJ, Brenner B. Atp Turnover by Individual Myosin Molecules Hints at Two Conformers of the Myosin Active Site. Proc Natl Acad Sci U S A. 2014;111(7):2536-41. Epub 2014/02/20.

Hinkel R, Trenkwalder T, Petersen B, Husada W, Gesenhues F, Lee S, Hannappel E, Bock-Marquette I, Theisen D, Leitner L, Boekstegers P, Cierniewski C, Muller OJ, le Noble F, Adams RH, Weinl C, Nordheim A, Reichart B, Weber C, Olson E, Posern G, Deindl E, Niemann H, Kupatt C. Mrtf-a Controls Vessel Growth and Maturation by Increasing the Expression of Ccn1 and Ccn2. Nat Commun. 2014;5:3970.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

Urrego R, Rodriguez-Osorio N, Niemann H. Epigenetic Disorders and Altered Gene Expression after Use of Assisted Reproductive Technologies in Domestic Cattle. Epigenetics. 2014;9(6):803-15.

Petkov S, Hyttel P, Niemann H. The Small Molecule Inhibitors Pd0325091 and Chir99021 Reduce Expression of Pluripotency-Related Genes in Putative Porcine Induced Pluripotent Stem Cells. Cell Reprogram. 2014;16(4):235-40.

Brenner B, Seebohm B, Tripathi S, Montag J, Kraft T. Familial Hypertrophic Cardiomyopathy: Functional Variance among Individual Cardiomyocytes as a Trigger of Fhc-Phenotype Development. Front Physiol. 2014;5:392. Epub 2014/10/28.

Witjas-Paalberends ER, Ferrara C, Scellini B, Piroddi N, Montag J, Tesi C, Stienen GJ, Michels M, Ho CY, Kraft T, Poggesi C, van der Velden J. Faster Cross-Bridge Detachment and Increased Tension Cost in Human Hypertrophic Cardiomyopathy with the R403q Myh7 Mutation. J Physiol. 2014;592(Pt 15):3257-72. Epub 2014/06/15.

Merkert S, Wunderlich S, Bednarski C, Beier J, Haase A, Dreyer AK, Schwanke K, Meyer J, Gohring G, Cathomen T, Martin U. Efficient Designer Nuclease-Based Homologous Recombination Enables Direct Pcr Screening for Footprintless Targeted Human Pluripotent Stem Cells. Stem Cell Reports. 2014;2(1):107-18.

2013

Petkov S, Hyttel P, Niemann H. The Choice of Expression Vector Promoter Is an Important Factor in the Reprogramming of Porcine Fibroblasts into Induced Pluripotent Cells. Cell Reprogram. 2013;15(1):1-8.

Kues WA, Herrmann D, Barg-Kues B, Haridoss S, Nowak-Imialek M, Buchholz T, Streeck M, Grebe A, Grabundzija I, Merkert S, Martin U, Hall VJ, Rasmussen MA, Ivics Z, Hyttel P, Niemann H. Derivation and Characterization of Sleeping Beauty Transposon-Mediated Porcine Induced Pluripotent Stem Cells. Stem Cells Dev. 2013;22(1):124-35.

Herrmann D, Dahl JA, Lucas-Hahn A, Collas P, Niemann H. Histone Modifications and Mrna Expression in the Inner Cell Mass and Trophectoderm of Bovine Blastocysts. Epigenetics. 2013;8(3):281-9.

Hauschild-Quintern J, Petersen B, Cost GJ, Niemann H. Gene Knockout and Knockin by Zinc-Finger Nucleases: Current Status and Perspectives. Cell Mol Life Sci. 2013;70(16):2969-83.

Kraft T, Witjas-Paalberends ER, Boontje NM, Tripathi S, Brandis A, Montag J, Hodgkinson JL, Francino A, Navarro-Lopez F, Brenner B, Stienen GJ, van der Velden J. Familial Hypertrophic Cardiomyopathy: Functional Effects of Myosin Mutation R723g in Cardiomyocytes. J Mol Cell Cardiol. 2013;57:13-22. Epub 2013/01/16.

Pfaff N, Lachmann N, Ackermann M, Kohlscheen S, Brendel C, Maetzig T, Niemann H, Antoniou MN, Grez M, Schambach A, Cantz T, Moritz T. A Ubiquitous Chromatin Opening Element Prevents Transgene Silencing in Pluripotent Stem Cells and Their Differentiated Progeny. Stem Cells. 2013;31(3):488-99.

2012

Garrels W, Kues WB, Herrmann D, Holler S, Baulain U, Niemann H. Ectopic Expression of Human Telomerase Rna Component Results in Increased Telomerase Activity and Elongated Telomeres in Bovine Blastocysts. Biol Reprod. 2012;87(4):95.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Semaan M, Kaulitz D, Petersen B, Niemann H, Denner J. Long-Term Effects of Perv-Specific Rna Interference in Transgenic Pigs. Xenotransplantation. 2012;19(2):112-21.

Brenner B, Hahn N, Hanke E, Matinmehr F, Scholz T, Steffen W, Kraft T. Mechanical and Kinetic Properties of Beta-Cardiac/Slow Skeletal Muscle Myosin. J Muscle Res Cell Motil. 2012;33(6):403-17. Epub 2012/08/01.

Nowak-Imialek M, Niemann H. Pluripotent Cells in Farm Animals: State of the Art and Future Perspectives. Reprod Fertil Dev. 2012;25(1):103-28.

Niemann H, Kind A, Schnieke A. Production of Biopharmaceuticals in Transgenic Animals. Pharmaceutical Biotechnology: Wiley-VCH Verlag GmbH & Co. KGaA; 2012. p. 71-111.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84. Epub 2012/12/01.

2011

Deshmukh RS, Ostrup O, Ostrup E, Vejlsted M, Niemann H, Lucas-Hahn A, Petersen B, Li J, Callesen H, Hyttel P. DNA Methylation in Porcine Preimplantation Embryos Developed in Vivo and Produced by in Vitro Fertilization, Parthenogenetic Activation and Somatic Cell Nuclear Transfer. Epigenetics. 2011;6(2):177-87.

Hauschild J, Petersen B, Santiago Y, Queisser AL, Carnwath JW, Lucas-Hahn A, Zhang L, Meng X, Gregory PD, Schwinzer R, Cost GJ, Niemann H. Efficient Generation of a Biallelic Knockout in Pigs Using Zinc-Finger Nucleases. Proc Natl Acad Sci U S A. 2011;108(29):12013-7.

El Hajj N, Trapphoff T, Linke M, May A, Hansmann T, Kuhtz J, Reifenberg K, Heinzmann J, Niemann H, Daser A, Eichenlaub-Ritter U, Zechner U, Haaf T. Limiting Dilution Bisulfite (Pyro)Sequencing Reveals Parent-Specific Methylation Patterns in Single Early Mouse Embryos and Bovine Oocytes. Epigenetics. 2011;6(10):1176-88.

Nowak-Imialek M, Kues WA, Petersen B, Lucas-Hahn A, Herrmann D, Haridoss S, Oropeza M, Lemme E, Scholer HR, Carnwath JW, Niemann H. Oct4-Enhanced Green Fluorescent Protein Transgenic Pigs: A New Large Animal Model for Reprogramming Studies. Stem Cells Dev. 2011;20(9):1563-75.

Nowak-Imialek M, Kues W, Carnwath JW, Niemann H. Pluripotent Stem Cells and Reprogrammed Cells in Farm Animals. Microsc Microanal. 2011;17(4):474-97.

Kuetemeyer K, Lucas-Hahn A, Petersen B, Niemann H, Heisterkamp A. Femtosecond Laser-Induced Fusion of Nonadherent Cells and Two-Cell Porcine Embryos. J Biomed Opt. 2011;16(8):088001.

Garrels W, Mates L, Holler S, Dalda A, Taylor U, Petersen B, Niemann H, Izsvak Z, Ivics Z, Kues WA. Germline Transgenic Pigs by Sleeping Beauty Transposition in Porcine Zygotes and Targeted Integration in the Pig Genome. PLoS One. 2011;6(8):e23573.

Iqbal K, Kues WA, Baulain U, Garrels W, Herrmann D, Niemann H. Species-Specific Telomere Length Differences between Blastocyst Cell Compartments and Ectopic Telomere Extension in Early Bovine Embryos by Human Telomerase Reverse Transcriptase. Biol Reprod. 2011;84(4):723-33.

Petersen B, Ramackers W, Lucas-Hahn A, Lemme E, Hassel P, Queisser AL, Herrmann D, Barg-Kues B, Carnwath JW, Klose J, Tiede A, Friedrich L, Baars W, Schwinzer R, Winkler M, Niemann H. Transgenic Expression of Human Heme Oxygenase-1 in Pigs Confers Resistance against Xenograft Rejection During Ex Vivo Perfusion of Porcine Kidneys. Xenotransplantation. 2011;18(6):355-68.

2010

Kuetemeyer K, Lucas-Hahn A, Petersen B, Lemme E, Hassel P, Niemann H, Heisterkamp A. Combined Multiphoton Imaging and Automated Functional Enucleation of Porcine Oocytes Using Femtosecond Laser Pulses. J Biomed Opt. 2010;15(4):046006.

Niemann H, Carnwath JW, Herrmann D, Wieczorek G, Lemme E, Lucas-Hahn A, Olek S. DNA Methylation Patterns Reflect Epigenetic Reprogramming in Bovine Embryos. Cell Reprogram. 2010;12(1):33-42.

Nowak-Imialek M, Kues WA, Rudolph C, Schlegelberger B, Taylor U, Carnwath JW, Niemann H. Preferential Loss of Porcine Chromosomes in Reprogrammed Interspecies Cell Hybrids. Cell Reprogram. 2010;12(1):55-65.

2008

Niemann H, Tian XC, King WA, Lee RS. Epigenetic Reprogramming in Embryonic and Foetal Development Upon Somatic Cell Nuclear Transfer Cloning. Reproduction. 2008;135(2):151-63. Epub 2008/02/02.

Kues WA, Sudheer S, Herrmann D, Carnwath JW, Havlicek V, Besenfelder U, Lehrach H, Adjaye J, Niemann H. Genome-Wide Expression Profiling Reveals Distinct Clusters of Transcriptional Regulation During Bovine Preimplantation Development in Vivo. Proc Natl Acad Sci U S A. 2008;105(50):19768-73.

2004

Schaetzlein S, Lucas-Hahn A, Lemme E, Kues WA, Dorsch M, Manns MP, Niemann H, Rudolph KL. Telomere Length Is Reset During Early Mammalian Embryogenesis. Proc Natl Acad Sci U S A. 2004;101(21):8034-8. Epub 2004/05/19.

Unit 9.1 - Large Animal Models - Subgroup Cardiovascular Models

Kraft T, Witjas-Paalberends ER, Boontje NM, Tripathi S, Brandis A, Montag J, Hodgkinson JL, Francino A, Navarro-Lopez F, Brenner B, Stienen GJ, van der Velden J. Familial hypertrophic cardiomyopathy: functional effects of myosin mutation R723G in cardiomyocytes. J Mol Cell Cardiol. 2013;57:13-22. Epub 2013/01/16.

Tripathi S, Schultz I, Becker E, Montag J, Borchert B, Francino A, Navarro-Lopez F, Perrot A, Ozcelik C, Osterziel KJ, McKenna WJ, Brenner B, Kraft T. Unequal allelic expression of wild-type and mutated beta-myosin in familial hypertrophic cardiomyopathy. Basic Res Cardiol. 2011;106(6):1041-55. Epub 2011/07/20.

Seebohm B, Matinmehr F, Kohler J, Francino A, Navarro-Lopez F, Perrot A, Ozcelik C, McKenna WJ, Brenner B, Kraft T. Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance. Biophys J. 2009;97(3):806-24. Epub 2009/08/05.

Köhler J, Winkler G, Schulte I, Scholz T, McKenna W, Brenner B, Kraft T. Mutation of the myosin converter domain alters cross-bridge elasticity. Proc Natl Acad Sci U S A. 2002;99(6):3557-62. Epub 2002/03/21.

Unit 9.2 - Pathology of Humanized Animal Models - Human Pathology

2017

Sommer W, Buechler G, Jansson K, Avsar M, Knofel AK, Salman J, Hoeffler K, Siemeni T, Gottlieb J, Karstens JH, Jonigk D, Reising A, Haverich A, Struber M, Warnecke G. Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine. Transpl Int. 2017.

2016

Zhang R, Magel L, Jonigk D, Langer F, Lippmann T, Zardo P, Polzing F. Biosynthetic Nanostructured Cellulose Patch for Chest Wall Reconstruction: Five-Month Follow-up in a Porcine Model. J Invest Surg. 2016:1-6.

Zhang R, Bures M, Hoffler K, Jonigk D, Haverich A, Krueger M. In Vitro Comparison of Two Widely Used Surgical Sealants for Treating Alveolar Air Leak. Thorac Cardiovasc Surg. 2016.

Winny M, Grethe L, Maegel L, Jonigk D, Lippmann T, Klempnauer J, Poehnert D. Impairment of the Peritoneal Surface as a Decisive Factor for Intestinal Adhesions in Intraperitoneal Onlay Mesh Surgery - Introducing a New Rat Model. Int J Med Sci. 2016;13(2):108-12.

Siemeni T, Knofel AK, Madrahimov N, Sommer W, Avsar M, Salman J, Ius F, Frank N, Buchler G, Jonigk D, Jansson K, Maus U, Tudorache I, Falk CS, Haverich A, Warnecke G. In Vivo Development of Transplant Arteriosclerosis in Humanized Mice Reflects Alloantigen Recognition and Peripheral Treg Phenotype of Lung Transplant Recipients. Am J Transplant. 2016;16(11):3150-62.

Schneider RK, Schenone M, Ferreira MV, Kramann R, Joyce CE, Hartigan C, Beier F, Brummendorf TH, Germing U, Platzbecker U, Busche G, Knuchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley RC, Carr SA, Ebert BL. Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nat Med. 2016;22(3):288-97.

Salari A, Thomay K, Himmler K, Vajen B, Schienke A, Hagedorn M, Ebersold J, Kreipe HH, Kruger A, Schambach A, Schlegelberger B, Gohring G. Establishing a murine xenograft-model for long-term analysis of factors inducing chromosomal instability in myelodysplastic syndrome: Pitfalls and successes. Cancer Genet. 2016;209(6):258-66.

Poehnert D, Grethe L, Maegel L, Jonigk D, Lippmann T, Kaltenborn A, Schrem H, Klempnauer J, Winny M. Evaluation of the Effectiveness of Peritoneal Adhesion Prevention Devices in a Rat Model. Int J Med Sci. 2016;13(7):524-32.

Pils MC, Dreckmann K, Jansson K, Glage S, Held N, Sommer W, Langer F, Avsar M, Warnecke G, Bleich A. Mortality Due to Porcine Reproductive and Respiratory Syndrome Virus in Immunocompromised Gottingen Minipigs (Sus scrofa domestica). Comp Med. 2016;66(5):392-8.

Kruger M, Zinne N, Biancosino C, Hoffler K, Rajab TK, Waldmann KH, Jonigk D, Avsar M, Haverich A, Hoeltig D. Porcine pulmonary auto-transplantation for ex vivo therapy as a model for new treatment strategies. Interact Cardiovasc Thorac Surg. 2016;23(3):358-66.

Khalili-Harbi N, Herath N, Solass W, Giger-Pabst U, Dutreix M, Reymond MA. Pressurized intraluminal aerosol chemotherapy with Dbait in the distal esophagus of swine. Endoscopy. 2016;48(2):184-7.

Kellner M, Heidrich M, Lorbeer RA, Antonopoulos GC, Knudsen L, Wrede C, Izykowski N, Grothausmann R, Jonigk D, Ochs M, Ripken T, Kuhnel MP, Meyer H. A combined method for correlative 3D imaging of biological samples from macro to nano scale. Scientific reports. 2016;6:35606.

Izykowski N, Kuehnel M, Hussein K, Mitschke K, Gunn M, Janciauskiene S, Haverich A, Warnecke G, Laenger F, Maus U, Jonigk D. Organizing pneumonia in mice and men. J Transl Med. 2016;14(1):169.

Hueper K, Gutberlet M, Brasen JH, Jang MS, Thorenz A, Chen R, Hertel B, Barrmeyer A, Schmidbauer M, Meier M, von Vietinghoff S, Khalifa A, Hartung D, Haller H, Wacker F, Rong S, Gueler F. Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice. PloS one. 2016;11(9):e0162705.

Huang K, Yang M, Pan Z, Heidel FH, Scherr M, Eder M, Fischer T, Busche G, Welte K, von Neuhoff N, Ganser A, Li Z. Leukemogenic potency of the novel FLT3-N676K mutant. Ann Hematol. 2016;95(5):783-91.

Hockendorf U, Yabal M, Herold T, Munkhbaatar E, Rott S, Jilg S, Kauschinger J, Magnani G, Reisinger F, Heuser M, Kreipe H, Sotlar K, Engleitner T, Rad R, Weichert W, Peschel C, Ruland J, Heikenwalder M, Spiekermann K, Slotta-Huspenina J, Gross O, Jost PJ. RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells. Cancer Cell. 2016;30(1):75-91.

Hering T, Braubach P, Landwehrmeyer GB, Lindenberg KS, Melzer W. Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington's Disease. PloS one. 2016;11(11):e0166106.

Gren ST, Janciauskiene S, Sandeep S, Jonigk D, Kvist PH, Gerwien JG, Hakansson K, Grip O. The protease inhibitor cystatin C down-regulates the release of IL-beta and TNF-alpha in lipopolysaccharide activated monocytes. J Leukoc Biol. 2016;100(4):811-22.

Bures M, Zardo P, Langer F, Zhang R. Improved application technique of albumin-glutaraldehyde glue for repair of superficial lung defects. J Cardiothorac Surg. 2016;11(1):149.

Bures M, Hoffler HK, Friedel G, Kyriss T, Boedeker E, Langer F, Zardo P, Zhang R. Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment. J Cardiothorac Surg. 2016;11(1):63.

Behler-Janbeck F, Takano T, Maus R, Stolper J, Jonigk D, Tort Tarres M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, Yamasaki S, Maus UA. C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia. PLoS Pathog. 2016;12(12):e1006038.

Avsar M, Jansson K, Sommer W, Kruse B, Thissen S, Dreckmann K, Knoefel AK, Salman J, Hafer C, Hecker J, Buechler G, Karstens JH, Jonigk D, Langer F, Kaever V, Falk CS, Hewicker-Trautwein M, Ungefroren H, Haverich A, Struber M, Warnecke G. Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine. Am J Transplant. 2016;16(5):1371-82.

2015

Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, Jonigk D, Izykowski N, Magel L, Welte T, Yamasaki S, Maus UA. Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cells Contribute to Control of Splenic Mycobacterium Bovis Bcg Infection in Mice. Infect Immun. 2015;83(1):184-96. Epub 2014/10/22.

Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grasser F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM. Smad7 Regulates Compensatory Hepatocyte Proliferation in Damaged Mouse Liver and Positively Relates to Better Clinical Outcome in Human Hepatocellular Carcinoma. Clin Sci (Lond). 2015;128(11):761-74.

Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, Falk CS, Ardesjo Lundgren B, Scott HS, Pich A, Anderson MS, Manns MP, Jaeckel E. Autoimmune Hepatitis in a Murine Autoimmune Polyendocrine Syndrome Type 1 Model Is Directed against Multiple Autoantigens. Hepatology. 2015;61(4):1295-305. Epub 2014/12/06.

Kohlscheen S, Wintterle S, Schwarzer A, Kamp C, Brugman MH, Breuer DC, Busche G, Baum C, Modlich U. Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance. PLoS One. 2015;10(7):e0131866.

Poehnert D, Abbas M, Maegel L, Sambale F, Lavrentieva A, Kreipe HH, Klempnauer J, Winny M. Evaluation of the Biological Tolerability of the Starch-Based Medical Device 4dryfield(R) Ph in Vitro and in Vivo a Rat Model. J Biomater Appl. 2015. Epub 2015/06/28.

Sommer W, Knofel AK, Izykowski N, Oldhafer F, Avsar M, Jonigk D, Warnecke G, Haverich A. Physical Exercise Reduces Transplant Arteriosclerosis in a Mouse Aorta Transplantation Model. J Thorac Cardiovasc Surg. 2015;149(1):330-7.

Sommer W, Knofel AK, Madrahimov N, Avsar M, Jonigk D, Salman J, Dreckmann K, Jansson K, Salguero G, Maus UA, Welte T, Haverich A, Warnecke G. Allogeneic Cd4+Cd25high T Cells Regulate Obliterative Bronchiolitis of Heterotopic Bronchus Allografts in Both Porcinized and Humanized Mouse Models. Transplantation. 2015;99(3):482-91. Epub 2015/02/20.

2014

Zhang R, Bures M, Hoffler K, Jonigk D, Haverich A, Krueger M. In Vitro Comparison of Two Widely Used Surgical Sealants for Treating Alveolar Air Leak. Thorac Cardiovasc Surg. 2014;62(8):705-9. Epub 2014/09/11.

Yang M, Huang K, Busche G, Ganser A, Li Z. Activation of Trkb Receptor in Murine Hematopoietic Stem/Progenitor Cells Induced Mastocytosis. Blood. 2014;124(7):1196-7. Epub 2014/08/16.

Salguero G, Daenthanasanmak A, Munz C, Raykova A, Guzman CA, Riese P, Figueiredo C, Langer F, Schneider A, Macke L, Sundarasetty BS, Witte T, Ganser A, Stripecke R. Dendritic Cell-Mediated Immune Humanization of Mice: Implications for Allogeneic and Xenogeneic Stem Cell Transplantation. J Immunol. 2014;192(10):4636-47.

Ramackers W, Friedrich L, Klose J, Vondran F, Bergmann S, Schuttler W, Johanning K, Werwitzke S, Trummer A, Brocker V, Klempnauer J, Winkler M, Tiede A. Recombinant Human Antithrombin Prevents Xenogenic Activation of Hemostasis in a Model of Pig-to-Human Kidney Transplantation. Xenotransplantation. 2014;21(4):367-75.

2013

Zell S, Schmitt R, Witting S, Kreipe HH, Hussein K, Becker JU. Hypoxia Induces Mesenchymal Gene Expression in Renal Tubular Epithelial Cells: An in Vitro Model of Kidney Transplant Fibrosis. Nephron Extra. 2013;3(1):50-8.

Yang M, Busche G, Ganser A, Li Z. Morphology and Quantitative Composition of Hematopoietic Cells in Murine Bone Marrow and Spleen of Healthy Subjects. Ann Hematol. 2013;92(5):587-94.

Yang M, Busche G, Ganser A, Li Z. Cytological Characterization of Murine Bone Marrow and Spleen Hematopoietic Compartments for Improved Assessment of Toxicity in Preclinical Gene Marking Models. Ann Hematol. 2013;92(5):595-604.

Wolf S, Rudolph C, Morgan M, Busche G, Salguero G, Stripecke R, Schlegelberger B, Baum C, Modlich U. Selection for Evi1 Activation in Myelomonocytic Leukemia Induced by Hyperactive Signaling through Wild-Type Nras. Oncogene. 2013;32(25):3028-38. Epub 2012/08/01.

Wende E, Laudeley R, Bleich A, Bleich E, Wetsel RA, Glage S, Klos A. The Complement Anaphylatoxin C3a Receptor (C3ar) Contributes to the Inflammatory Response in Dextran Sulfate Sodium (Dss)-Induced Colitis in Mice. PLoS One. 2013;8(4):e62257. Epub 2013/05/03.

Vajen B, Modlich U, Schienke A, Wolf S, Skawran B, Hofmann W, Busche G, Kreipe H, Baum C, Santos-Barriopedro I, Vaquero A, Schlegelberger B, Rudolph C. Histone Methyltransferase Suv39h1 Deficiency Prevents Myc-Induced Chromosomal Instability in Murine Myeloid Leukemias. Genes Chromosomes Cancer. 2013;52(4):423-30.

Neumann D, Beermann S, Burhenne H, Glage S, Hartwig C, Seifert R. The Dual H3/4r Antagonist Thioperamide Does Not Fully Mimic the Effects of the 'Standard' H4r Antagonist Jnj 7777120 in Experimental Murine Asthma. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(11):983-90.

Mandel K, Yang Y, Schambach A, Glage S, Otte A, Hass R. Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth in Vitro and in Vivo. Stem Cells Dev. 2013;22(23):3114-27.

Kotlarz D, Zietara N, Uzel G, Weidemann T, Braun CJ, Diestelhorst J, Krawitz PM, Robinson PN, Hecht J, Puchalka J, Gertz EM, Schaffer AA, Lawrence MG, Kardava L, Pfeifer D, Baumann U, Pfister ED, Hanson EP, Schambach A, Jacobs R, Kreipe H, Moir S, Milner JD, Schwille P, Mundlos S, Klein C. Loss-of-Function Mutations in the Il-21 Receptor Gene Cause a Primary Immunodeficiency Syndrome. J Exp Med. 2013;210(3):433-43.

Kezic A, Thaiss F, Becker JU, Tsui TY, Bajcetic M. Effects of Everolimus on Oxidative Stress in Kidney Model of Ischemia/Reperfusion Injury. Am J Nephrol. 2013;37(4):291-301.

Kezic A, Becker JU, Thaiss F. The Effect of Mtor-Inhibition on Nf-Kappab Activity in Kidney Ischemia-Reperfusion Injury in Mice. Transplant Proc. 2013;45(5):1708-14.

Karra N, Nassar T, Laenger F, Benita S, Borlak J. Safety and Proof-of-Concept Efficacy of Inhaled Drug Loaded Nano- and Immunonanoparticles in a C-Raf Transgenic Lung Cancer Model. Curr Cancer Drug Targets. 2013;13(1):11-29.

Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Kohler R, Miura H, Langer F, Reichenspurner H, Robbins RC, Schrepfer S. The Potassium Channel Kca3.1 as New Therapeutic Target for the Prevention of Obliterative Airway Disease. Transplantation. 2013;95(2):285-92. Epub 2013/01/18.

Hesse D, Ehlert N, Luenhop T, Smoczek A, Glage S, Behrens P, Muller PP, Esser KH, Lenarz T, Stieve M, Bleich A, Prenzler NK. Nanoporous Silica Coatings as a Drug Delivery System for Ciprofloxacin: Outcome of Variable Release Rates in the Infected Middle Ear of Rabbits. Otol Neurotol. 2013;34(6):1138-45.

Hardtke-Wolenski M, Fischer K, Noyan F, Schlue J, Falk CS, Stahlhut M, Woller N, Kuehnel F, Taubert R, Manns MP, Jaeckel E. Genetic Predisposition and Environmental Danger Signals Initiate Chronic Autoimmune Hepatitis Driven by Cd4+ T Cells. Hepatology. 2013;58(2):718-28.

Haas DA, Bala K, Busche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Ruckert J, Varga Z, Keri G, Schulz TF. The Inflammatory Kinase Map4k4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells. PLoS Pathog. 2013;9(11):e1003737.

Dutow P, Lingner S, Laudeley R, Glage S, Hoymann HG, Dittrich AM, Fehlhaber B, Muller M, Braun A, Klos A. Severity of Allergic Airway Disease Due to House Dust Mite Allergen Is Not Increased after Clinical Recovery of Lung Infection with Chlamydia Pneumoniae in Mice. Infect Immun. 2013;81(9):3366-74. Epub 2013/07/03.

Boer U, Spengler C, Klingenberg M, Jonigk D, Harder M, Kreipe HH, Haverich A, Wilhelmi M. Cytotoxic Effects of Polyhexanide on Cellular Repopulation and Calcification of Decellularized Equine Carotids in Vitro and in Vivo. Int J Artif Organs. 2013;36(3):184-94.

Boer U, Spengler C, Jonigk D, Klingenberg M, Schrimpf C, Lutzner S, Harder M, Kreipe HH, Haverich A, Wilhelmi M. Coating Decellularized Equine Carotid Arteries with Ccn1 Improves Cellular Repopulation, Local Biocompatibility, and Immune Response in Sheep. Tissue Eng Part A. 2013;19(15-16):1829-42.

Atanasova S, Hirschburger M, Jonigk D, Obert M, Petri K, Evers A, Hecker A, Schmitz J, Kaufmann A, Wilhelm J, Chakraborty T, Warnecke G, Gottlieb J, Padberg W, Grau V. A Relevant Experimental Model for Human Bronchiolitis Obliterans Syndrome. J Heart Lung Transplant. 2013;32(11):1131-9.

2012

Böer U, Lutzner S, Jonigk D, Klingenberg M, Haverich A, Wilhelmi M. Effect of CCN1 coating of decellularized equine carotid arteries on local biocompatibility and humoral immunogenicity in a heterogenous animal model. Biomed Tech (Berl). 2012. Epub 2012/09/05.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84. Epub 2012/12/01.

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Steinwede K, Maus R, Bohling J, Voedisch S, Braun A, Ochs M, Schmiedl A, Langer F, Gauthier F, Roes J, Welte T, Bange FC, Niederweis M, Buhling F, Maus UA. Cathepsin G and Neutrophil Elastase Contribute to Lung-Protective Immunity against Mycobacterial Infections in Mice. J Immunol. 2012;188(9):4476-87. Epub 2012/03/31.

Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K. Interactions among Hcls1, Hax1 and Lef-1 Proteins Are Essential for G-Csf-Triggered Granulopoiesis. Nat Med. 2012;18(10):1550-9. Epub 2012/09/25.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Otte A, Gohring G, Steinemann D, Schlegelberger B, Groos S, Langer F, Kreipe HH, Schambach A, Neumann T, Hillemanns P, Park-Simon TW, Hass R. A Tumor-Derived Population (Sccoht-1) as Cellular Model for a Small Cell Ovarian Carcinoma of the Hypercalcemic Type. Int J Oncol. 2012;41(2):765-75.

Hunecke D, Spanel R, Langer F, Nam SW, Borlak J. Myc-Regulated Genes Involved in Liver Cell Dysplasia Identified in a Transgenic Model of Liver Cancer. J Pathol. 2012;228(4):520-33.

Hueper K, Elalfy M, Laenger F, Halter R, Rodt T, Galanski M, Borlak J. Pet/Ct Imaging of C-Myc Transgenic Mice Identifies the Genotoxic N-Nitroso-Diethylamine as Carcinogen in a Short-Term Cancer Bioassay. PLoS One. 2012;7(2):e30432. Epub 2012/02/10.

Buurman R, Gurlevik E, Schaffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kuhnel F, Skawran B. Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing Microrna-449 in Hepatocellular Carcinoma Cells. Gastroenterology. 2012;143(3):811-20 e1-15.

Beermann S, Glage S, Jonigk D, Seifert R, Neumann D. Opposite Effects of Mepyramine on Jnj 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation. PLoS One. 2012;7(1):e30285.

2011

Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Langer F, Christman JW, Paton JC, Ask K, Maharaj S, Kolb M, Gauldie J, Welte T, Maus UA. Local Delivery of Gm-Csf Protects Mice from Lethal Pneumococcal Pneumonia. J Immunol. 2011;187(10):5346-56.

Seth S, Ravens I, Lee CW, Glage S, Bleich A, Forster R, Bernhardt G, Koenecke C. Absence of Cd155 Aggravates Acute Graft-Versus-Host Disease. Proc Natl Acad Sci U S A. 2011;108(10):E32-3; author reply E4.

Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Busche G, Ganser A, Stripecke R. Lentiviral Vectors for Induction of Self-Differentiation and Conditional Ablation of Dendritic Cells. Gene Ther. 2011;18(8):750-64.

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T. Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases. PLoS One. 2011;6(12):e28911.

Northrup E, Eisenblatter R, Glage S, Rudolph C, Dorsch M, Schlegelberger B, Hedrich HJ, Zschemisch NH. Loss of Dnd1 Facilitates the Cultivation of Genital Ridge-Derived Rat Embryonic Germ Cells. Exp Cell Res. 2011;317(13):1885-94.

Meyer-Schwesinger C, Lange C, Brocker V, Agustian P, Lehmann U, Raabe A, Brinkmeyer M, Kobayashi E, Schiffer M, Busche G, Kreipe HH, Thaiss F, Becker JU. Bone Marrow-Derived Progenitor Cells Do Not Contribute to Podocyte Turnover in the Puromycin Aminoglycoside and Renal Ablation Models in Rats. Am J Pathol. 2011;178(2):494-9. Epub 2011/02/02.

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I. Induced Pluripotent Stem Cell (Ipsc)-Derived Flk-1 Progenitor Cells Engraft, Differentiate, and Improve Heart Function in a Mouse Model of Acute Myocardial Infarction. Eur Heart J. 2011;32(21):2634-41.

Kleinschmidt K, Klinge PM, Stopa E, Wallrapp C, Glage S, Geigle P, Brinker T. Alginate Encapsulated Human Mesenchymal Stem Cells Suppress Syngeneic Glioma Growth in the Immunocompetent Rat. J Microencapsul. 2011;28(7):621-7.

Heckl D, Wicke DC, Brugman MH, Meyer J, Schambach A, Busche G, Ballmaier M, Baum C, Modlich U. Lentiviral Gene Transfer Regenerates Hematopoietic Stem Cells in a Mouse Model for Mpl-Deficient Aplastic Anemia. Blood. 2011;117(14):3737-47.

2010

Wiegmann B, Zardo P, Dickgreber N, Langer F, Fegbeutel C, Haverich A, Fischer S. Biological Materials in Chest Wall Reconstruction: Initial Experience with the Peri-Guard Repair Patch. Eur J Cardiothorac Surg. 2010;37(3):602-5.

Wicke DC, Meyer J, Buesche G, Heckl D, Kreipe H, Li Z, Welte KH, Ballmaier M, Baum C, Modlich U. Gene Therapy of Mpl Deficiency: Challenging Balance between Leukemia and Pancytopenia. Mol Ther. 2010;18(2):343-52. Epub 2009/10/22.

Poehnert D, Broecker V, Mengel M, Nashan B, Koch M. Induction of Chronic Renal Allograft Dysfunction in a Rat Model with Complete and Exclusive Mhc Incompatibility. Transpl Immunol. 2010;22(3-4):137-43.

Nolff MC, Kokemueller H, Hauschild G, Fehr M, Bormann KH, Spalthoff S, Rohn K, Ruecker M, Gellrich NC. Comparison of Computed Tomography and Microradiography for Graft Evaluation after Reconstruction of Critical Size Bone Defects Using Beta-Tricalcium Phosphate. J Craniomaxillofac Surg. 2010;38(1):38-46. Epub 2009/08/25.

Kokemueller H, Spalthoff S, Nolff M, Tavassol F, Essig H, Stuehmer C, Bormann KH, Rucker M, Gellrich NC. Prefabrication of Vascularized Bioartificial Bone Grafts in Vivo for Segmental Mandibular Reconstruction: Experimental Pilot Study in Sheep and First Clinical Application. Int J Oral Maxillofac Surg. 2010;39(4):379-87.

Hesse E, Kluge G, Atfi A, Correa D, Haasper C, Berding G, Shin HO, Viering J, Langer F, Vogt PM, Krettek C, Jagodzinski M. Repair of a Segmental Long Bone Defect in Human by Implantation of a Novel Multiple Disc Graft. Bone. 2010;46(5):1457-63.

Christgen M, Geffers R, Ballmaier M, Christgen H, Poczkaj J, Krech T, Kreipe H, Lehmann U. Down-Regulation of the Fetal Stem Cell Factor Sox17 by H33342: A Mechanism Responsible for Differential Gene Expression in Breast Cancer Side Population Cells. J Biol Chem. 2010;285(9):6412-8.

Bisdas T, Bredt M, Pichlmaier M, Aper T, Wilhelmi M, Bisdas S, Haverich A, Teebken OE. Eight-Year Experience with Cryopreserved Arterial Homografts for the in Situ Reconstruction of Abdominal Aortic Infections. J Vasc Surg. 2010;52(2):323-30.

2009

Zhao F, Vermeer B, Lehmann U, Kreipe H, Manns MP, Korangy F, Greten TF. Identification of a Novel Murine Pancreatic Tumour Antigen, Which Elicits Antibody Responses in Patients with Pancreatic Carcinoma. Immunology. 2009;128(1):134-40. Epub 2009/08/20.

Winter C, Herbold W, Maus R, Langer F, Briles DE, Paton JC, Welte T, Maus UA. Important Role for Cc Chemokine Ligand 2-Dependent Lung Mononuclear Phagocyte Recruitment to Inhibit Sepsis in Mice Infected with Streptococcus Pneumoniae. J Immunol. 2009;182(8):4931-7.

Warnecke G, Hutchinson JA, Riquelme P, Kruse B, Thissen S, Avsar M, Zehle G, Steinkamp T, Peters C, Baumann R, Govert F, Ungefroren H, Langer F, Simon AR, Karstens JH, Kaever V, Haverich A, Fandrich F, Struber M. Postoperative Intravenous Infusion of Donor-Derived Transplant Acceptance-Inducing Cells as an Adjunct Immunosuppressive Therapy in a Porcine Pulmonary Allograft Model. Transpl Int. 2009;22(3):332-41. Epub 2008/10/29.

Singh AK, Riederer B, Krabbenhoft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential Roles of Nherf1, Nherf2, and Pdzk1 in Regulating Cftr-Mediated Intestinal Anion Secretion in Mice. J Clin Invest. 2009;119(3):540-50.

Schmitt R, Jacobi C, Susnik N, Broecker V, Haller H, Melk A. Ageing Mouse Kidney--Not Always the Same Old Story. Nephrol Dial Transplant. 2009;24(10):3002-5. Epub 2009/05/29.

Kruse B, Thissen S, Warnecke G, Avsar M, Gottlieb J, Hohlfeld JM, Karstens JH, Kaever V, Langer F, Pabst B, Ungefroren H, Haverich A, Struber M. Correlation of Donor Leukocyte Chimerism with Pulmonary Allograft Survival after Immunosuppressive Drug Withdrawal in a Porcine Model. Transplantation. 2009;87(10):1468-77.

Kocks JR, Adler H, Danzer H, Hoffmann K, Jonigk D, Lehmann U, Forster R. Chemokine Receptor Ccr7 Contributes to a Rapid and Efficient Clearance of Lytic Murine Gamma-Herpes Virus 68 from the Lung, Whereas Bronchus-Associated Lymphoid Tissue Harbors Virus During Latency. J Immunol. 2009;182(11):6861-9.

Huber TB, Hartleben B, Winkelmann K, Schneider L, Becker JU, Leitges M, Walz G, Haller H, Schiffer M. Loss of Podocyte Apkclambda/Iota Causes Polarity Defects and Nephrotic Syndrome. J Am Soc Nephrol. 2009;20(4):798-806.

Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR, Martin U. Generation of Induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell. 2009;5(4):434-41.

Ghosh A, Koestner W, Hapke M, Schlaphoff V, Langer F, Baumann R, Koenecke C, Cornberg M, Welte K, Blazar BR, Sauer MG. Donor T Cells Primed on Leukemia Lysate-Pulsed Recipient Apcs Mediate Strong Graft-Versus-Leukemia Effects across Mhc Barriers in Full Chimeras. Blood. 2009;113(18):4440-8.

2008

Fischer K, Wolenski M, Manns MP, Jaeckel E. A new animal model of chronic autoimmune hepatitis mediated by the adaptive immune system. Paper presented at: 2008 EASL Monothematic Conference: Immune Mediated Liver Injury; Hamburg, Dec. 4-6, 2008.

Srivastava M, Steinwede K, Kiviranta R, Morko J, Hoymann HG, Langer F, Buhling F, Welte T, Maus UA. Overexpression of Cathepsin K in Mice Decreases Collagen Deposition and Lung Resistance in Response to Bleomycin-Induced Pulmonary Fibrosis. Respir Res. 2008;9:54.

Schubert S, Kamino K, Bohm D, Adham I, Engel W, von Wasielewski R, Moharregh-Khiabani D, Mauceri G, Vaske B, Meinhardt A, Schoner A, Gonzalez-Fassrainer D, Schmidtke J. Tspy Expression Is Variably Altered in Transgenic Mice with Testicular Feminization. Biol Reprod. 2008;79(1):125-33. Epub 2008/04/11.

Schreiber O, Steinwede K, Ding N, Srivastava M, Maus R, Länger F, Prokein J, Ehlers S, Welte T, Gunn MD, Maus UA. Mice That Overexpress Cc Chemokine Ligand 2 in Their Lungs Show Increased Protective Immunity to Infection with Mycobacterium Bovis Bacille Calmette-Guérin. Journal of Infectious Diseases. 2008;198(7):1044-54.

Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, Golpon H, Olsson K, Wilkins MR, Gibbs JS, Hoeper MM, Wollert KC. Growth Differentiation Factor-15 in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2008;178(5):534-41.

Metzelder M, Kuebler J, Shimotakahara A, Vieten G, von Wasielewski R, Ure BM. Co(2) Pneumoperitoneum Increases Systemic but Not Local Tumor Spread after Intraperitoneal Murine Neuroblastoma Spillage in Mice. Surg Endosc. 2008;22(12):2648-53. Epub 2008/02/14.

Ma B, Wang L, von Wasielewski R, Lindenmaier W, Dittmar KE. Serial Sectioning and Three-Dimensional Reconstruction of Mouse Peyer's Patch. Micron. 2008;39(7):967-75.

Lamle J, Marhenke S, Borlak J, von Wasielewski R, Eriksson CJ, Geffers R, Manns MP, Yamamoto M, Vogel A. Nuclear Factor-Eythroid 2-Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury. Gastroenterology. 2008;134(4):1159-68.

Haile LA, von Wasielewski R, Gamrekelashvili J, Kruger C, Bachmann O, Westendorf AM, Buer J, Liblau R, Manns MP, Korangy F, Greten TF. Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease: A New Immunoregulatory Pathway. Gastroenterology. 2008;135(3):871-81, 81 e1-5.

Bleich A, Sundberg JP, Smoczek A, von Wasielewski R, de Buhr MF, Janus LM, Julga G, Ukena SN, Hedrich HJ, Gunzer F. Sensitivity to Escherichia Coli Nissle 1917 in Mice Is Dependent on Environment and Genetic Background. Int J Exp Pathol. 2008;89(1):45-54. Epub 2007/11/17.

2007

Winter C, Taut K, Srivastava M, Langer F, Mack M, Briles DE, Paton JC, Maus R, Welte T, Gunn MD, Maus UA. Lung-Specific Overexpression of Cc Chemokine Ligand (Ccl) 2 Enhances the Host Defense to Streptococcus Pneumoniae Infection in Mice: Role of the Ccl2-Ccr2 Axis. J Immunol. 2007;178(9):5828-38.

Winter C, Taut K, Langer F, Mack M, Briles DE, Paton JC, Maus R, Srivastava M, Welte T, Maus UA. Fms-Like Tyrosine Kinase 3 Ligand Aggravates the Lung Inflammatory Response to Streptococcus Pneumoniae Infection in Mice: Role of Dendritic Cells. J Immunol. 2007;179(5):3099-108.

Ma B, von Wasielewski R, Lindenmaier W, Dittmar KE. Immmunohistochemical Study of the Blood and Lymphatic Vasculature and the Innervation of Mouse Gut and Gut-Associated Lymphoid Tissue. Anat Histol Embryol. 2007;36(1):62-74.

Lenarz M, Lim HH, Lenarz T, Reich U, Marquardt N, Klingberg MN, Paasche G, Reuter G, Stan AC. Auditory Midbrain Implant: Histomorphologic Effects of Long-Term Implantation and Electric Stimulation of a New Deep Brain Stimulation Array. Otol Neurotol. 2007;28(8):1045-52.

Gamrekelashvili J, Kruger C, von Wasielewski R, Hoffmann M, Huster KM, Busch DH, Manns MP, Korangy F, Greten TF. Necrotic Tumor Cell Death in Vivo Impairs Tumor-Specific Immune Responses. J Immunol. 2007;178(3):1573-80.

Christgen M, Ballmaier M, Bruchhardt H, von Wasielewski R, Kreipe H, Lehmann U. Identification of a Distinct Side Population of Cancer Cells in the Cal-51 Human Breast Carcinoma Cell Line. Mol Cell Biochem. 2007;306(1-2):201-12.

Bocchia M, Vannucchi AM, Gozzetti A, Guglielmelli P, Poli G, Crupi R, Defina M, Bosi A, Francesco L. Insights into Jak2-V617f Mutation in Cml. Lancet Oncol. 2007;8(10):864-6. Epub 2007/10/05.

Unit 9.3 - Histopathology of Animal Models and Teratoma - Veterinary Pathology

2017

Schrimpf C, Wrede C, Glage S, Hegermann J, Backhaus S, Blasczyk R, Heuft HG, Muller T. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus). Transfusion. 2017;57(1):60-9.

2016

Zschemisch NH, Brusch I, Hambusch AS, Bleich A. Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir. PloS one. 2016;11(5):e0155821.

Witt L, Glage S, Lichtinghagen R, Pape L, Boethig D, Dennhardt N, Heiderich S, Leffler A, Sumpelmann R. Impact of high doses of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model. Paediatr Anaesth. 2016;26(3):259-65.

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M. Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology. Stem cells translational medicine. 2016;5(5):591-601.

Rausch P, Basic M, Batra A, Bischoff SC, Blaut M, Clavel T, Glasner J, Gopalakrishnan S, Grassl GA, Gunther C, Haller D, Hirose M, Ibrahim S, Loh G, Mattner J, Nagel S, Pabst O, Schmidt F, Siegmund B, Strowig T, Volynets V, Wirtz S, Zeissig S, Zeissig Y, Bleich A, Baines JF. Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities. Int J Med Microbiol. 2016;306(5):343-55.

Pils MC, Dreckmann K, Jansson K, Glage S, Held N, Sommer W, Langer F, Avsar M, Warnecke G, Bleich A. Mortality Due to Porcine Reproductive and Respiratory Syndrome Virus in Immunocompromised Gottingen Minipigs (Sus scrofa domestica). Comp Med. 2016;66(5):392-8.

Peuker K, Muff S, Wang J, Kunzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Rocken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med. 2016;22(5):506-15.

Petkov S, Glage S, Nowak-Imialek M, Niemann H. Long-Term Culture of Porcine Induced Pluripotent Stem-Like Cells Under Feeder-Free Conditions in the Presence of Histone Deacetylase Inhibitors. Stem Cells Dev. 2016;25(5):386-94.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kuhnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem cell reports. 2016;7(2):292-305.

Hager C, Glage S, Held N, Bleich EM, Burghard A, Mahler M, Bleich A. Detection of antibodies against Theiler's murine encephalomyelitis virus GDVII strain in experimental guinea pigs. Lab Anim. 2016;50(5):400-3.

Elmore SA, Dixon D, Hailey JR, Harada T, Herbert RA, Maronpot RR, Nolte T, Rehg JE, Rittinghausen S, Rosol TJ, Satoh H, Vidal JD, Willard-Mack CL, Creasy DM. Recommendations from the INHAND Apoptosis/Necrosis Working Group. Toxicol Pathol. 2016;44(2):173-88.

Dutow P, Wask L, Bothe M, Fehlhaber B, Laudeley R, Rheinheimer C, Yang Z, Zhong G, Glage S, Klos A. An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions. Pathog Dis. 2016;74(2).

Dupont A, Sommer F, Zhang K, Repnik U, Basic M, Bleich A, Kuhnel M, Backhed F, Litvak Y, Fulde M, Rosenshine I, Hornef MW. Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice. PLoS Pathog. 2016;12(5):e1005616.

2015

Milanez-Almeida P, Ulas T, Pasztoi M, Glage S, Schughart K, Lutz MB, Schultze JL, Huehn J. CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Eur J Microbiol Immunol (Bp). 2015;5(4):246-55.

Schaubeck M, Clavel T, Calasan J, Lagkouvardos I, Haange SB, Jehmlich N, Basic M, Dupont A, Hornef M, Bergen MV, Bleich A, Haller D. Dysbiotic Gut Microbiota Causes Transmissible Crohn's Disease-Like Ileitis Independent of Failure in Antimicrobial Defence. Gut. 2015. Epub 2015/04/19.

Torow N, Yu K, Hassani K, Freitag J, Schulz O, Basic M, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Forster R, Pabst O, Hornef MW. Active Suppression of Intestinal Cd4(+)Tcralphabeta(+) T-Lymphocyte Maturation During the Postnatal Period. Nat Commun. 2015;6:7725. Epub 2015/07/22.

Ginzburg K, Kutz I, Koifman B, Roth A, Kriwisky M, David D, Bleich A. Acute Stress Disorder Symptoms Predict All-Cause Mortality among Myocardial Infarction Patients: A 15-Year Longitudinal Study. Ann Behav Med. 2015. Epub 2015/10/29.

Volynets V, Reichold A, Bardos G, Rings A, Bleich A, Bischoff SC. Assessment of the Intestinal Barrier with Five Different Permeability Tests in Healthy C57bl/6j and Balb/Cj Mice. Dig Dis Sci. 2015. Epub 2015/11/02.

Duda F, Bradel S, Bleich A, Abendroth P, Heemeier T, Ehlert N, Behrens P, Esser KH, Lenarz T, Brandes G, Prenzler NK. Biocompatibility of Silver Containing Silica Films on Bioverit(R) Ii Middle Ear Prostheses in Rabbits. J Biomater Appl. 2015;30(1):17-29. Epub 2015/02/11.

Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, Lunnemann M, Goldstein J, Singh AK, Riederer B, Bachmann O, Bleich A, Gereke M, Bruder D, Hagen S, He P, Yun C, Seidler U. Evidence for a Causal Link between Adaptor Protein Pdzk1 Downregulation and Na(+)/H(+) Exchanger Nhe3 Dysfunction in Human and Murine Colitis. Pflugers Arch. 2015;467(8):1795-807. Epub 2014/10/02.

Gunther C, Buchen B, He GW, Hornef M, Torow N, Neumann H, Wittkopf N, Martini E, Basic M, Bleich A, Watson AJ, Neurath MF, Becker C. Caspase-8 Controls the Gut Response to Microbial Challenges by Tnf-Alpha-Dependent and Independent Pathways. Gut. 2015;64(4):601-10. Epub 2014/11/08.

Keenan CM, Baker J, Bradley A, Goodman DG, Harada T, Herbert R, Kaufmann W, Kellner R, Mahler B, Meseck E, Nolte T, Rittinghausen S, Vahle J, Yoshizawa K. International Harmonization of Nomenclature and Diagnostic Criteria (Inhand): Progress to Date and Future Plans. Toxicol Pathol. 2015;43(5):730-2. Epub 2014/12/23.

Nicklas W, Keubler L, Bleich A. Maintaining and Monitoring the Defined Microbiota Status of Gnotobiotic Rodents. ILAR J. 2015;56(2):241-9. Epub 2015/09/02.

Hartwig C, Munder A, Glage S, Wedekind D, Schenk H, Seifert R, Neumann D. The Histamine H4 -Receptor (H4 R) Regulates Eosinophilic Inflammation in Ovalbumin-Induced Experimental Allergic Asthma in Mice. Eur J Immunol. 2015;45(4):1129-40. Epub 2014/12/17.

Schirmer B, Wedekind D, Glage S, Neumann D. Deletion of Il-18 Expression Ameliorates Spontaneous Kidney Failure in Mrllpr Mice. PLoS One. 2015;10(10):e0140173. Epub 2015/10/16.

Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Niemann H, Kues WA. Derivation and Characterization of Bovine Induced Pluripotent Stem Cells by Transposon-Mediated Reprogramming. Cell Reprogram. 2015;17(2):131-40. Epub 2015/04/01.

Lindner C, Thomsen I, Wahl B, Ugur M, Sethi MK, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, Schreiber S, Bleich A, Gaboriau-Routhiau V, Cerf-Bensussan N, Hazanov H, Mehr R, Boysen P, Rosenstiel P, Pabst O. Diversification of Memory B Cells Drives the Continuous Adaptation of Secretory Antibodies to Gut Microbiota. Nat Immunol. 2015;16(8):880-8. Epub 2015/07/07.

Rausch P, Steck N, Suwandi A, Seidel JA, Kunzel S, Bhullar K, Basic M, Bleich A, Johnsen JM, Vallance BA, Baines JF, Grassl GA. Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection. PLoS Pathog. 2015;11(7):e1005008. Epub 2015/07/03.

Out C, Patankar JV, Doktorova M, Boesjes M, Bos T, de Boer S, Havinga R, Wolters H, Boverhof R, van Dijk TH, Smoczek A, Bleich A, Sachdev V, Kratky D, Kuipers F, Verkade HJ, Groen AK. Gut Microbiota Inhibit Asbt-Dependent Intestinal Bile Acid Reabsorption Via Gata4. J Hepatol. 2015;63(3):697-704. Epub 2015/05/30.

Bleich A, Fox JG. The Mammalian Microbiome and Its Importance in Laboratory Animal Research. ILAR J. 2015;56(2):153-8. Epub 2015/09/02.

Keubler LM, Buettner M, Häger C, Bleich A. A Multihit Model: Colitis Lessons from the Interleukin-10–Deficient Mouse. Inflammatory Bowel Diseases. 2015;21(8):1967-75.

Hager C, Keubler LM, Biernot S, Dietrich J, Buchheister S, Buettner M, Bleich A. Time to Integrate to Nest Test Evaluation in a Mouse Dss-Colitis Model. PLoS One. 2015;10(12):e0143824. Epub 2015/12/05.

2014

Witt L, Glage S, Schulz K, Lichtinghagen R, Simann A, Pape L, Sumpelmann R. Impact of 6% Hydroxyethyl Starch 130/0.42 and 4% Gelatin on Renal Function in a Pediatric Animal Model. Paediatr Anaesth. 2014;24(9):974-9.

Warlich E, Schambach A, Lock D, Wedekind D, Glage S, Eckardt D, Bosio A, Knobel S. Fas-Based Cell Depletion Facilitates the Selective Isolation of Mouse Induced Pluripotent Stem Cells. PLoS One. 2014;9(7):e102171.

Chatterji B, Dickhut C, Mielke S, Kruger J, Just I, Glage S, Meier M, Wedekind D, Pich A. Maldi Imaging Mass Spectrometry to Investigate Endogenous Peptides in an Animal Model of Usher's Disease. Proteomics. 2014;14(13-14):1674-87.

Rittinghausen S, Hackbarth A, Creutzenberg O, Ernst H, Heinrich U, Leonhardt A, Schaudien D. The Carcinogenic Effect of Various Multi-Walled Carbon Nanotubes (Mwcnts) after Intraperitoneal Injection in Rats. Part Fibre Toxicol. 2014;11:59. Epub 2014/11/21.

Dutow P, Fehlhaber B, Bode J, Laudeley R, Rheinheimer C, Glage S, Wetsel RA, Pabst O, Klos A. The Complement C3a Receptor Is Critical in Defense against Chlamydia Psittaci in Mouse Lung Infection and Required for Antibody and Optimal T Cell Response. J Infect Dis. 2014;209(8):1269-78.

Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Kues WA. Non-Viral Reprogramming of Fibroblasts into Induced Pluripotent Stem Cells by Sleeping Beauty and Piggybac Transposons. Biochem Biophys Res Commun. 2014;450(1):581-7.

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9.

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M. Ripk1 Maintains Epithelial Homeostasis by Inhibiting Apoptosis and Necroptosis. Nature. 2014;513(7516):90-4. Epub 2014/08/19.

Ganesh V, Baru AM, Hesse C, Friedrich C, Glage S, Gohmert M, Janke C, Sparwasser T. Salmonella Enterica Serovar Typhimurium Infection-Induced Cd11b+ Gr1+ Cells Ameliorate Allergic Airway Inflammation. Infect Immun. 2014;82(3):1052-63.

Zschemisch NH, Eisenblatter R, Rudolph C, Glage S, Dorsch M. Immortalized Tumor Derived Rat Fibroblasts as Feeder Cells Facilitate the Cultivation of Male Embryonic Stem Cells from the Rat Strain Wky/Ztm. Springerplus. 2014;3:588.

2013

Hesse D, Ehlert N, Luenhop T, Smoczek A, Glage S, Behrens P, Muller PP, Esser KH, Lenarz T, Stieve M, Bleich A, Prenzler NK. Nanoporous Silica Coatings as a Drug Delivery System for Ciprofloxacin: Outcome of Variable Release Rates in the Infected Middle Ear of Rabbits. Otol Neurotol. 2013;34(6):1138-45.

Wende E, Laudeley R, Bleich A, Bleich E, Wetsel RA, Glage S, Klos A. The Complement Anaphylatoxin C3a Receptor (C3ar) Contributes to the Inflammatory Response in Dextran Sulfate Sodium (Dss)-Induced Colitis in Mice. PLoS One. 2013;8(4):e62257.

Neumann D, Beermann S, Burhenne H, Glage S, Hartwig C, Seifert R. The Dual H3/4r Antagonist Thioperamide Does Not Fully Mimic the Effects of the 'Standard' H4r Antagonist Jnj 7777120 in Experimental Murine Asthma. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(11):983-90.

Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, Von Erichsen J, Yoshida T. Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium. J Toxicol Pathol. 2013;26(3 Suppl):1S-26S. Epub 2013/01/01.

Lensing R, Bleich A, Smoczek A, Glage S, Ehlert N, Luessenhop T, Behrens P, Müller PP, Kietzmann M, Stieve M. Efficacy of Nanoporous Silica Coatings on Middle Ear Prostheses as a Delivery System for Antibiotics: An Animal Study in Rabbits. Acta Biomaterialia. 2013;9(1):4815-25.

Mandel K, Yang Y, Schambach A, Glage S, Otte A, Hass R. Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth in Vitro and in Vivo. Stem Cells Dev. 2013;22(23):3114-27.

Dutow P, Lingner S, Laudeley R, Glage S, Hoymann HG, Dittrich AM, Fehlhaber B, Muller M, Braun A, Klos A. Severity of Allergic Airway Disease Due to House Dust Mite Allergen Is Not Increased after Clinical Recovery of Lung Infection with Chlamydia Pneumoniae in Mice. Infect Immun. 2013;81(9):3366-74.

Hesse D, Badar M, Bleich A, Smoczek A, Glage S, Kieke M, Behrens P, Muller PP, Esser KH, Stieve M, Prenzler NK. Layered Double Hydroxides as Efficient Drug Delivery System of Ciprofloxacin in the Middle Ear: An Animal Study in Rabbits. J Mater Sci Mater Med. 2013;24(1):129-36.

Glage S, Wittur I, Elfers C, Hedrich HJ, Dorsch M. Treatment of Male Mice with Gonadotropins to Improve the Fertilization Rate and Reproduction. Lab Anim. 2013;47(1):26-30.

Hiller B, Achleitner M, Glage S, Naumann R, Behrendt R, Roers A. Mammalian Rnase H2 Removes Ribonucleotides from DNA to Maintain Genome Integrity. J Exp Med. 2012;209(8):1419-26.

2012

Glage S, Lewis AL, Mertens P, Baltes S, Geigle P, Brinker T. Evaluation of Biocompatibility and Anti-Glioma Efficacy of Doxorubicin and Irinotecan Drug-Eluting Bead Suspensions in Alginate. Clin Transl Oncol. 2012;14(1):50-9.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84. Epub 2012/12/01.

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Bode J, Dutow P, Sommer K, Janik K, Glage S, Tummler B, Munder A, Laudeley R, Sachse KW, Klos A. A New Role of the Complement System: C3 Provides Protection in a Mouse Model of Lung Infection with Intracellular Chlamydia Psittaci. PLoS One. 2012;7(11):e50327.

Baraki H, Zinne N, Wedekind D, Meier M, Bleich A, Glage S, Hedrich HJ, Kutschka I, Haverich A. Magnetic Resonance Imaging of Soft Tissue Infection with Iron Oxide Labeled Granulocytes in a Rat Model. PLoS One. 2012;7(12):e51770.

Beermann S, Glage S, Jonigk D, Seifert R, Neumann D. Opposite Effects of Mepyramine on Jnj 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation. PLoS One. 2012;7(1):e30285.

Plentz RR, Palagani V, Wiedemann A, Diekmann U, Glage S, Naujok O, Jorns A, Muller T. Islet Microarchitecture and Glucose Transporter Expression of the Pancreas of the Marmoset Monkey Display Similarities to the Human. Islets. 2012;4(2):123-9.

Baru AM, Ganesh V, Krishnaswamy JK, Hesse C, Untucht C, Glage S, Behrens G, Mayer CT, Puttur F, Sparwasser T. Absence of Foxp3+ Regulatory T Cells During Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation. PLoS One. 2012;7(10):e47102.

Sterenczak KA, Meier M, Glage S, Meyer M, Willenbrock S, Wefstaedt P, Dorsch M, Bullerdiek J, Murua Escobar H, Hedrich H, Nolte I. Longitudinal Mri Contrast Enhanced Monitoring of Early Tumour Development with Manganese Chloride (Mncl2) and Superparamagnetic Iron Oxide Nanoparticles (Spios) in a Ct1258 Based in Vivo Model of Prostate Cancer. BMC Cancer. 2012;12:284.

Grothusen C, Schuett H, Hillmer A, Lumpe S, Grote K, Ballmaier M, Bleich A, Glage S, Tietge UJ, Luchtefeld M, Schieffer B. Role of Suppressor of Cytokine Signaling-1 in Murine Atherosclerosis. PLoS One. 2012;7(12):e51608.

Xiao F, Juric M, Li J, Riederer B, Yeruva S, Singh AK, Zheng L, Glage S, Kollias G, Dudeja P, Tian DA, Xu G, Zhu J, Bachmann O, Seidler U. Loss of Downregulated in Adenoma (Dra) Impairs Mucosal Hco3(-) Secretion in Murine Ileocolonic Inflammation. Inflamm Bowel Dis. 2012;18(1):101-11.

Rodt T, Luepke M, Boehm C, Hueper K, Halter R, Glage S, Hoy L, Wacker F, Borlak J, von Falck C. Combined Micro-Pet/Micro-Ct Imaging of Lung Tumours in Spc-Raf and Spc-Myc Transgenic Mice. PLoS One. 2012;7(9):e44427.

Northrup E, Zschemisch NH, Eisenblatter R, Glage S, Wedekind D, Cuppen E, Dorsch M, Hedrich HJ. The Ter Mutation in the Rat Dnd1 Gene Initiates Gonadal Teratomas and Infertility in Both Genders. PLoS One. 2012;7(5):e38001.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Rothe M, Rittelmeyer I, Iken M, Rudrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U. Epidermal Growth Factor Improves Lentivirus Vector Gene Transfer into Primary Mouse Hepatocytes. Gene Ther. 2012;19(4):425-34.

2011

Zschemisch NH, Glage S, Wedekind D, Weinstein EJ, Cui X, Dorsch M, Hedrich HJ. Zinc-Finger Nuclease Mediated Disruption of Rag1 in the Lew/Ztm Rat. BMC Immunol. 2012;13:60.

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T. Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases. PLoS One. 2011;6(12):e28911.

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I. Induced Pluripotent Stem Cell (Ipsc)-Derived Flk-1 Progenitor Cells Engraft, Differentiate, and Improve Heart Function in a Mouse Model of Acute Myocardial Infarction. Eur Heart J. 2011;32(21):2634-41.

2010

Olmer R, Haase A, Merkert S, Cui W, Palecek J, Ran C, Kirschning A, Scheper T, Glage S, Miller K, Curnow EC, Hayes ES, Martin U. Long Term Expansion of Undifferentiated Human Ips and Es Cells in Suspension Culture Using a Defined Medium. Stem Cell Res. 2010;5(1):51-64.

2009

Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR, Martin U. Generation of Induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell. 2009;5(4):434-41.

Unit 9.4 - Preclinical Safety and Toxicology

2016

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M. Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology. Stem cells translational medicine. 2016;5(5):591-601.

2015

Pohler P, Muller M, Winkler C, Schaudien D, Sewald K, Muller TH, Seltsam A. Pathogen Reduction by Ultraviolet C Light Effectively Inactivates Human White Blood Cells in Platelet Products. Transfusion. 2015;55(2):337-47.

2014

Le DD, Rochlitzer S, Fischer A, Heck S, Tschernig T, Sester M, Bals R, Welte T, Braun A, Dinh QT. Allergic Airway Inflammation Induces the Migration of Dendritic Cells into Airway Sensory Ganglia. Respir Res. 2014;15:73.

Lauenstein L, Switalla S, Prenzler F, Seehase S, Pfennig O, Forster C, Fieguth H, Braun A, Sewald K. Assessment of Immunotoxicity Induced by Chemicals in Human Precision-Cut Lung Slices (Pcls). Toxicol In Vitro. 2014;28(4):588-99.

2013

Switalla S, Knebel J, Ritter D, Dasenbrock C, Krug N, Braun A, Sewald K. Determination of Genotoxicity by the Comet Assay Applied to Murine Precision-Cut Lung Slices. Toxicol In Vitro. 2013;27(2):798-803.

Rittinghausen S, Bellmann B, Creutzenberg O, Ernst H, Kolling A, Mangelsdorf I, Kellner R, Beneke S, Ziemann C. Evaluation of Immunohistochemical Markers to Detect the Genotoxic Mode of Action of Fine and Ultrafine Dusts in Rat Lungs. Toxicology. 2013;303:177-86.

Paranjpe M, Neuhaus V, Finke JH, Richter C, Gothsch T, Kwade A, Buttgenbach S, Braun A, Muller-Goymann CC. In Vitro and Ex Vivo Toxicological Testing of Sildenafil-Loaded Solid Lipid Nanoparticles. Inhal Toxicol. 2013;25(9):536-43.

Neuhaus V, Schwarz K, Klee A, Seehase S, Forster C, Pfennig O, Jonigk D, Fieguth HG, Koch W, Warnecke G, Yusibov V, Sewald K, Braun A. Functional Testing of an Inhalable Nanoparticle Based Influenza Vaccine Using a Human Precision Cut Lung Slice Technique. PLoS One. 2013;8(8):e71728.

Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, Von Erichsen J, Yoshida T. Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium. J Toxicol Pathol. 2013;26(3 Suppl):1S-26S.

Fuhst R, Runge F, Buschmann J, Ernst H, Praechter C, Hansen T, von Erichsen J, Turowska A, Hoymann HG, Muller M, Pohlmann G, Sewald K, Ziemann C, Schluter G, Garn H. Toxicity Profile of the Gata-3-Specific Dnazyme Hgd40 after Inhalation Exposure. Pulm Pharmacol Ther. 2013;26(2):281-9.

2012

Rodt T, von Falck C, Dettmer S, Hueper K, Halter R, Hoy L, Luepke M, Borlak J, Wacker F. Lung Tumour Growth Kinetics in Spc-C-Raf-1-Bb Transgenic Mice Assessed by Longitudinal in-Vivo Micro-Ct Quantification. J Exp Clin Cancer Res. 2012;31:15.

Unit 9.5 - Cytogenetic Profiling

2017

Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Gohring G, Schmidt H, Sgodda M, Cantz T. In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. Biol Chem. 2017.

Gohring G, Thomay K, Schmidt G, Ripperger T, Xu M, Wittner N, Chao MM, Baumann I, Niewisch M, Reinhardt D, Klingebiel T, Thol F, Schlegelberger B, Niemeyer CM. A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl. Leuk Lymphoma. 2017;58(3):718-21.

2016

Salari A, Thomay K, Himmler K, Vajen B, Schienke A, Hagedorn M, Ebersold J, Kreipe HH, Kruger A, Schambach A, Schlegelberger B, Gohring G. Establishing a murine xenograft-model for long-term analysis of factors inducing chromosomal instability in myelodysplastic syndrome: Pitfalls and successes. Cancer Genet. 2016;209(6):258-66.

Manukjan G, Ripperger T, Venturini L, Stadler M, Gohring G, Schambach A, Schlegelberger B, Steinemann D. GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. Stem cell research. 2016;16(3):677-81.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature communications. 2016;7:13602.

Hoffmann D, Gohring G, Heuser M, Ganser A, Schambach A, Morgan MA. Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation. Stem cells. 2016;34(3):797-9.

2015

Fabarius A, Kalmanti L, Dietz CT, Lauseker M, Rinaldetti S, Haferlach C, Gohring G, Schlegelberger B, Jotterand M, Hanfstein B, Seifarth W, Hanel M, Kohne CH, Lindemann HW, Berdel WE, Staib P, Muller MC, Proetel U, Balleisen L, Goebeler ME, Dengler J, Falge C, Kanz L, Burchert A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Brummendorf TH, Edinger M, Hofmann WK, Pfirrmann M, Hasford J, Krause S, Hochhaus A, Saussele S, Hehlmann R. Impact of Unbalanced Minor Route Versus Major Route Karyotypes at Diagnosis on Prognosis of Cml. Ann Hematol. 2015;94(12):2015-24. Epub 2015/09/20.

Fiedler W, Kayser S, Kebenko M, Janning M, Krauter J, Schittenhelm M, Gotze K, Weber D, Gohring G, Teleanu V, Thol F, Heuser M, Dohner K, Ganser A, Dohner H, Schlenk RF. A Phase I/Ii Study of Sunitinib and Intensive Chemotherapy in Patients over 60 Years of Age with Acute Myeloid Leukaemia and Activating Flt3 Mutations. Br J Haematol. 2015;169(5):694-700.

Heuser M, Meggendorfer M, Cruz MM, Fabisch J, Klesse S, Kohler L, Gohring G, Ganster C, Shirneshan K, Gutermuth A, Cerny-Reiterer S, Kronke J, Panagiota V, Haferlach C, Koenecke C, Platzbecker U, Thiede C, Schroeder T, Kobbe G, Ehrlich S, Stamer K, Dohner K, Valent P, Schlegelberger B, Kroeger N, Ganser A, Haase D, Haferlach T, Thol F. Frequency and Prognostic Impact of Casein Kinase 1a1 Mutations in Mds Patients with Deletion of Chromosome 5q. Leukemia. 2015;29(9):1942-5.

Schlegelberger B, Kreipe H, Lehmann U, Steinemann D, Ripperger T, Gohring G, Thomay K, Rump A, Di Donato N, Suttorp M. A Child with Li-Fraumeni Syndrome: Modes to Inactivate the Second Allele of Tp53 in Three Different Malignancies. Pediatr Blood Cancer. 2015;62(8):1481-4.

Naumann N, Schwaab J, Metzgeroth G, Jawhar M, Haferlach C, Gohring G, Schlegelberger B, Dietz CT, Schnittger S, Lotfi S, Gartner M, Dang TA, Hofmann WK, Cross NC, Reiter A, Fabarius A. Fusion of Pdgfrb to Mprip, Cpsf6, and Golgb1 in Three Patients with Eosinophilia-Associated Myeloproliferative Neoplasms. Genes Chromosomes Cancer. 2015;54(12):762-70.

Hoffmann D, Gohring G, Heuser M, Ganser A, Schambach A, Morgan MA. Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an Aml Diagnostic Sample Containing the T(8;21) Translocation. Stem Cells. 2015.

Koenecke C, Gohring G, de Wreede LC, van Biezen A, Scheid C, Volin L, Maertens J, Finke J, Schaap N, Robin M, Passweg J, Cornelissen J, Beelen D, Heuser M, de Witte T, Kroger N, EBMT MDSsotCMWPot. Impact of the Revised International Prognostic Scoring System, Cytogenetics and Monosomal Karyotype on Outcome after Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia Evolving from Myelodysplastic Syndromes: A Retrospective Multicenter Study of the European Society of Blood and Marrow Transplantation. Haematologica. 2015;100(3):400-8.

2014

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9. Epub 2014/03/19.

Schwanke K, Merkert S, Kempf H, Hartung S, Jara-Avaca M, Templin C, Gohring G, Haverich A, Martin U, Zweigerdt R. Fast and Efficient Multitransgenic Modification of Human Pluripotent Stem Cells. Hum Gene Ther Methods. 2014;25(2):136-53.

Heuser M, Panagiota V, Koenecke C, Fehse B, Alchalby H, Badbaran A, Shahswar R, Stadler M, Eder M, Gohring G, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kroeger N, Ganser A, Thol F. Low Frequency of Calreticulin Mutations in Mds Patients. Leukemia. 2014;28(9):1933-4.

Saft L, Karimi M, Ghaderi M, Matolcsy A, Mufti GJ, Kulasekararaj A, Gohring G, Giagounidis A, Selleslag D, Muus P, Sanz G, Mittelman M, Bowen D, Porwit A, Fu T, Backstrom J, Fenaux P, MacBeth KJ, Hellstrom-Lindberg E. P53 Protein Expression Independently Predicts Outcome in Patients with Lower-Risk Myelodysplastic Syndromes with Del(5q). Haematologica. 2014;99(6):1041-9.

Thomay K, Schienke A, Vajen B, Modlich U, Schambach A, Hofmann W, Schlegelberger B, Gohring G. Chromosomal Instability and Telomere Shortening in Long-Term Culture of Hematopoietic Stem Cells: Insights from a Cell Culture Model of Rps14 Haploinsufficiency. Cytogenet Genome Res. 2014;142(1):14-20.

Aalbers AM, van der Velden VH, Yoshimi A, Fischer A, Noellke P, Zwaan CM, Baumann I, Beverloo HB, Dworzak M, Hasle H, Locatelli F, De Moerloose B, Gohring G, Schmugge M, Stary J, Zecca M, Langerak AW, van Dongen JJ, Pieters R, Niemeyer CM, van den Heuvel-Eibrink MM. The Clinical Relevance of Minor Paroxysmal Nocturnal Hemoglobinuria Clones in Refractory Cytopenia of Childhood: A Prospective Study by Ewog-Mds. Leukemia. 2014;28(1):189-92.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Braun CJ, Boztug K, Paruzynski A, Witzel M, Schwarzer A, Rothe M, Modlich U, Beier R, Gohring G, Steinemann D, Fronza R, Ball CR, Haemmerle R, Naundorf S, Kuhlcke K, Rose M, Fraser C, Mathias L, Ferrari R, Abboud MR, Al-Herz W, Kondratenko I, Marodi L, Glimm H, Schlegelberger B, Schambach A, Albert MH, Schmidt M, von Kalle C, Klein C. Gene Therapy for Wiskott-Aldrich Syndrome--Long-Term Efficacy and Genotoxicity. Sci Transl Med. 2014;6(227):227ra33.

Giagounidis A, Mufti GJ, Mittelman M, Sanz G, Platzbecker U, Muus P, Selleslag D, Beyne-Rauzy O, te Boekhorst P, del Canizo C, Guerci-Bresler A, Nilsson L, Lubbert M, Quesnel B, Ganser A, Bowen D, Schlegelberger B, Gohring G, Fu T, Benettaib B, Hellstrom-Lindberg E, Fenaux P. Outcomes in Rbc Transfusion-Dependent Patients with Low-/Intermediate-1-Risk Myelodysplastic Syndromes with Isolated Deletion 5q Treated with Lenalidomide: A Subset Analysis from the Mds-004 Study. Eur J Haematol. 2014;93(5):429-38.

Reuter CW, Krauter J, Onono FO, Bunke T, Damm F, Thol F, Wagner K, Gohring G, Schlegelberger B, Heuser M, Ganser A, Morgan MA. Lack of Noncanonical Ras Mutations in Cytogenetically Normal Acute Myeloid Leukemia. Ann Hematol. 2014;93(6):977-82.

Woll PS, Kjallquist U, Chowdhury O, Doolittle H, Wedge DC, Thongjuea S, Erlandsson R, Ngara M, Anderson K, Deng Q, Mead AJ, Stenson L, Giustacchini A, Duarte S, Giannoulatou E, Taylor S, Karimi M, Scharenberg C, Mortera-Blanco T, Macaulay IC, Clark SA, Dybedal I, Josefsen D, Fenaux P, Hokland P, Holm MS, Cazzola M, Malcovati L, Tauro S, Bowen D, Boultwood J, Pellagatti A, Pimanda JE, Unnikrishnan A, Vyas P, Gohring G, Schlegelberger B, Tobiasson M, Kvalheim G, Constantinescu SN, Nerlov C, Nilsson L, Campbell PJ, Sandberg R, Papaemmanuil E, Hellstrom-Lindberg E, Linnarsson S, Jacobsen SE. Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells in Vivo. Cancer Cell. 2014;25(6):794-808.

Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek KJ, Kirchner A, Huang L, Chaturvedi A, Wichmann M, Wiehlmann L, Shahswar R, Damm F, Gohring G, Schlegelberger B, Schlenk R, Dohner K, Dohner H, Krauter J, Ganser A, Heuser M. Mutations in the Cohesin Complex in Acute Myeloid Leukemia: Clinical and Prognostic Implications. Blood. 2014;123(6):914-20.

Attarbaschi A, Panzer-Grumayer R, Mann G, Moricke A, Konig M, Mecklenbrauker A, Teigler-Schlegel A, Bradtke J, Harbott J, Gohring G, Stanulla M, Schrappe M, Zimmermann M, Haas OA. Minimal Residual Disease-Based Treatment Is Adequate for Relapse-Prone Childhood Acute Lymphoblastic Leukemia with an Intrachromosomal Amplification of Chromosome 21: The Experience of the All-Bfm 2000 Trial. Klin Padiatr. 2014;226(6-7):338-43. Epub 2014/11/29.

Feurstein S, Rucker FG, Bullinger L, Hofmann W, Manukjan G, Gohring G, Lehmann U, Heuser M, Ganser A, Dohner K, Schlegelberger B, Steinemann D. Haploinsufficiency of Etv6 and Cdkn1b in Patients with Acute Myeloid Leukemia and Complex Karyotype. BMC Genomics. 2014;15:784.

Skokowa J, Steinemann D, Katsman-Kuipers JE, Zeidler C, Klimenkova O, Klimiankou M, Unalan M, Kandabarau S, Makaryan V, Beekman R, Behrens K, Stocking C, Obenauer J, Schnittger S, Kohlmann A, Valkhof MG, Hoogenboezem R, Gohring G, Reinhardt D, Schlegelberger B, Stanulla M, Vandenberghe P, Donadieu J, Zwaan CM, Touw IP, van den Heuvel-Eibrink MM, Dale DC, Welte K. Cooperativity of Runx1 and Csf3r Mutations in Severe Congenital Neutropenia: A Unique Pathway in Myeloid Leukemogenesis. Blood. 2014;123(14):2229-37.

Yoshimi A, Strahm B, Baumann I, Furlan I, Schwarz S, Teigler-Schlegel A, Walther JU, Schlegelberger B, Gohring G, Nollke P, Fuhrer M, Niemeyer CM. Hematopoietic Stem Cell Transplantation in Children and Young Adults with Secondary Myelodysplastic Syndrome and Acute Myelogenous Leukemia after Aplastic Anemia. Biol Blood Marrow Transplant. 2014;20(3):425-9.

Damm F, Markus B, Thol F, Morgan M, Gohring G, Schlegelberger B, Krauter J, Heuser M, Bernard OA, Ganser A. Tet2 Mutations in Cytogenetically Normal Acute Myeloid Leukemia: Clinical Implications and Evolutionary Patterns. Genes Chromosomes Cancer. 2014;53(10):824-32.

Aalbers AM, van den Heuvel-Eibrink MM, Baumann I, Beverloo HB, Driessen GJ, Dworzak M, Fischer A, Göhring G, Hasle H, Locatelli F, De Moerloose B, Noellke P, Schmugge M, Stary J, Yoshimi A, Zecca M, Zwaan CM, van Dongen JJM, Pieters R, Niemeyer CM, van der Velden VHJ, Langerak AW. T-Cell Receptor Vβ Skewing Frequently Occurs in Refractory Cytopenia of Childhood and Is Associated with an Expansion of Effector Cytotoxic T Cells: A Prospective Study by Ewog-Mds. Blood Cancer Journal. 2014;4(5):e209.

Merkert S, Wunderlich S, Bednarski C, Beier J, Haase A, Dreyer AK, Schwanke K, Meyer J, Gohring G, Cathomen T, Martin U. Efficient Designer Nuclease-Based Homologous Recombination Enables Direct Pcr Screening for Footprintless Targeted Human Pluripotent Stem Cells. Stem Cell Reports. 2014;2(1):107-18.

Bug G, Koschmieder S, Krauter J, Heuser M, Thol F, Wiebe S, Hofmann WK, Klein SA, Wegener G, Gohring G, Heit W, Hoelzer D, Ganser A, Ottmann OG. Long-Term Results of a Prospective Randomized Trial Evaluating G-Csf Priming in Intensive Induction Chemotherapy Followed by Autologous Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia. Ann Hematol. 2014;93(2):193-202.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

Panagiota V, Thol F, Markus B, Fehse B, Alchalby H, Badbaran A, Lehmann U, Koenecke C, Shahswar R, Chaturvedi A, Stadler M, Eder M, Gohring G, Koenigsmann M, Kloos A, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kreipe HH, Ganser A, Kroger N, Heuser M. Prognostic Effect of Calreticulin Mutations in Patients with Myelofibrosis after Allogeneic Hematopoietic Stem Cell Transplantation. Leukemia. 2014;28(7):1552-5.

2013

Gross B, Sgodda M, Rasche M, Schambach A, Gohring G, Schlegelberger B, Greber B, Linden T, Reinhardt D, Cantz T, Klusmann JH. Improved Generation of Patient-Specific Induced Pluripotent Stem Cells Using a Chemically-Defined and Matrigel-Based Approach. Curr Mol Med. 2013;13(5):765-76.

Kronke J, Bullinger L, Teleanu V, Tschurtz F, Gaidzik VI, Kuhn MW, Rucker FG, Holzmann K, Paschka P, Kapp-Schworer S, Spath D, Kindler T, Schittenhelm M, Krauter J, Ganser A, Gohring G, Schlegelberger B, Schlenk RF, Dohner H, Dohner K. Clonal Evolution in Relapsed Npm1-Mutated Acute Myeloid Leukemia. Blood. 2013;122(1):100-8.

Thol F, Kolking B, Hollink IH, Damm F, van den Heuvel-Eibrink MM, Michel Zwaan C, Bug G, Ottmann O, Wagner K, Morgan M, Hofmann WK, Gohring G, Schlegelberger B, Krauter J, Ganser A, Heuser M. Analysis of Nup98/Nsd1 Translocations in Adult Aml and Mds Patients. Leukemia. 2013;27(3):750-4.

Schlenk RF, Taskesen E, van Norden Y, Krauter J, Ganser A, Bullinger L, Gaidzik VI, Paschka P, Corbacioglu A, Gohring G, Kundgen A, Held G, Gotze K, Vellenga E, Kuball J, Schanz U, Passweg J, Pabst T, Maertens J, Ossenkoppele GJ, Delwel R, Dohner H, Cornelissen JJ, Dohner K, Lowenberg B. The Value of Allogeneic and Autologous Hematopoietic Stem Cell Transplantation in Prognostically Favorable Acute Myeloid Leukemia with Double Mutant Cebpa. Blood. 2013;122(9):1576-82.

Steinemann D, Gohring G, Schlegelberger B. Genetic Instability of Modified Stem Cells - a First Step Towards Malignant Transformation? Am J Stem Cells. 2013;2(1):39-51.

Hauck G, Jonigk D, Gohring G, Kreipe H, Hussein K. Myelofibrosis in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms Is Associated with Aberrant Karyotypes. Cancer Genet. 2013;206(4):116-23.

Ripperger T, Tauscher M, Thomay K, Gohring G, Kraemer D, Schlegelberger B, Steinemann D. No Evidence for Itsn1 Loss in a Patient with Mental Retardation and Complex Chromosomal Rearrangements of 21q21-21q22. Leuk Res. 2013;37(6):721-3.

Thol F, Winschel C, Sonntag AK, Damm F, Wagner K, Chaturvedi A, Gohring G, Schlegelberger B, Lubbert M, Fiedler W, Kirchner H, Krauter J, Ganser A, Heuser M. Prognostic Significance of Expression Levels of Stem Cell Regulators Msi2 and Numb in Acute Myeloid Leukemia. Ann Hematol. 2013;92(3):315-23.

2012

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Khan S, Toews H, Wang JC, Arredondo J, Provias J, Gohring G, Barr RD. Acute Lymphoblastic Leukemia in a Patient with Constitutional Chromosome 1pter-P36.31 Duplication and 1q43-Qter Deletion. J Pediatr Hematol Oncol. 2012;34(3):217-21.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84.

Hanfstein B, Muller MC, Hehlmann R, Erben P, Lauseker M, Fabarius A, Schnittger S, Haferlach C, Gohring G, Proetel U, Kolb HJ, Krause SW, Hofmann WK, Schubert J, Einsele H, Dengler J, Hanel M, Falge C, Kanz L, Neubauer A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Branford S, Hughes TP, Spiekermann K, Baerlocher GM, Pfirrmann M, Hasford J, Saussele S, Hochhaus A, Sakk, German CMLSG. Early Molecular and Cytogenetic Response Is Predictive for Long-Term Progression-Free and Overall Survival in Chronic Myeloid Leukemia (Cml). Leukemia. 2012;26(9):2096-102.

Schlegelberger B, Gohring G, Thol F, Heuser M. Update on Cytogenetic and Molecular Changes in Myelodysplastic Syndromes. Leuk Lymphoma. 2012;53(4):525-36.

Otte A, Gohring G, Steinemann D, Schlegelberger B, Groos S, Langer F, Kreipe HH, Schambach A, Neumann T, Hillemanns P, Park-Simon TW, Hass R. A Tumor-Derived Population (Sccoht-1) as Cellular Model for a Small Cell Ovarian Carcinoma of the Hypercalcemic Type. Int J Oncol. 2012;41(2):765-75.

Serra A, Eirich K, Winkler AK, Mrasek K, Gohring G, Barbi G, Cario H, Schlegelberger B, Pokora B, Liehr T, Leriche C, Henne-Bruns D, Barth TF, Schindler D. Shared Copy Number Variation in Simultaneous Nephroblastoma and Neuroblastoma Due to Fanconi Anemia. Mol Syndromol. 2012;3(3):120-30.

Giagounidis AA, Kulasekararaj A, Germing U, Radkowski R, Haase S, Petersen P, Gohring G, Busche G, Aul C, Mufti GJ, Platzbecker U. Long-Term Transfusion Independence in Del(5q) Mds Patients Who Discontinue Lenalidomide. Leukemia. 2012;26(4):855-8.

Middeke JM, Beelen D, Stadler M, Gohring G, Schlegelberger B, Baurmann H, Bug G, Bellos F, Mohr B, Buchholz S, Schwerdtfeger R, Martin H, Hegenbart U, Ehninger G, Bornhauser M, Schetelig J, Cooperative German Transplant Study G. Outcome of High-Risk Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation: Negative Impact of Abnl(17p) and -5/5q. Blood. 2012;120(12):2521-8.

Gohring G, Lange K, Hofmann W, Nielsen KV, Hellstrom-Lindberg E, Roy L, Morgan M, Kreipe H, Busche G, Giagounidis A, Schlegelberger B. Telomere Shortening, Clonal Evolution and Disease Progression in Myelodysplastic Syndrome Patients with 5q Deletion Treated with Lenalidomide. Leukemia. 2012;26(2):356-8.

Damm F, Thol F, Kosmider O, Kade S, Loffeld P, Dreyfus F, Stamatoullas-Bastard A, Tanguy-Schmidt A, Beyne-Rauzy O, de Botton S, Guerci-Bresler A, Gohring G, Schlegelberger B, Ganser A, Bernard OA, Fontenay M, Heuser M. Sf3b1 Mutations in Myelodysplastic Syndromes: Clinical Associations and Prognostic Implications. Leukemia. 2012;26(5):1137-40.

Thol F, Yun H, Sonntag AK, Damm F, Weissinger EM, Krauter J, Wagner K, Morgan M, Wichmann M, Gohring G, Bug G, Ottmann O, Hofmann WK, Schambach A, Schlegelberger B, Haferlach T, Bowen D, Mills K, Ganser A, Heuser M. Prognostic Significance of Combined Mn1, Erg, Baalc, and Evi1 (Mebe) Expression in Patients with Myelodysplastic Syndromes. Ann Hematol. 2012;91(8):1221-33.

Thol F, Kade S, Schlarmann C, Loffeld P, Morgan M, Krauter J, Wlodarski MW, Kolking B, Wichmann M, Gorlich K, Gohring G, Bug G, Ottmann O, Niemeyer CM, Hofmann WK, Schlegelberger B, Ganser A, Heuser M. Frequency and Prognostic Impact of Mutations in Srsf2, U2af1, and Zrsr2 in Patients with Myelodysplastic Syndromes. Blood. 2012;119(15):3578-84.

Pauli S, Steinemann D, Dittmann K, Wienands J, Shoukier M, Moschner M, Burfeind P, Manukjan G, Gohring G, Escherich G. Occurrence of Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia in a Patient with Noonan Syndrome Carrying the Germline Ptpn11 Mutation P.E139d. Am J Med Genet A. 2012;158A(3):652-8.

Damm F, Bunke T, Thol F, Markus B, Wagner K, Gohring G, Schlegelberger B, Heil G, Reuter CW, Pullmann K, Schlenk RF, Dohner K, Heuser M, Krauter J, Dohner H, Ganser A, Morgan MA. Prognostic Implications and Molecular Associations of Nadh Dehydrogenase Subunit 4 (Nd4) Mutations in Acute Myeloid Leukemia. Leukemia. 2012;26(2):289-95.

Xu H, Menendez S, Schlegelberger B, Bae N, Aplan PD, Gohring G, Deblasio TR, Nimer SD. Loss of P53 Accelerates the Complications of Myelodysplastic Syndrome in a Nup98-Hoxd13-Driven Mouse Model. Blood. 2012;120(15):3089-97.

Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, Knoess S, Krause J, Li Z, Schlegelberger B, Baum C, Modlich U. Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia. Mol Ther. 2012;20(6):1187-95.

Kayser S, Zucknick M, Dohner K, Krauter J, Kohne CH, Horst HA, Held G, von Lilienfeld-Toal M, Wilhelm S, Rummel M, Germing U, Gotze K, Nachbaur D, Schlegelberger B, Gohring G, Spath D, Morlok C, Teleanu V, Ganser A, Dohner H, Schlenk RF, German-Austrian AMLSG. Monosomal Karyotype in Adult Acute Myeloid Leukemia: Prognostic Impact and Outcome after Different Treatment Strategies. Blood. 2012;119(2):551-8.

2011

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T. Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases. PLoS One. 2011;6(12):e28911.

Baum C, Modlich U, Gohring G, Schlegelberger B. Concise Review: Managing Genotoxicity in the Therapeutic Modification of Stem Cells. Stem Cells. 2011;29(10):1479-84.

Hussein K, Busche G, Muth M, Gohring G, Kreipe H, Bock O. Expression of Myelopoiesis-Associated Microrna in Bone Marrow Cells of Atypical Chronic Myeloid Leukaemia and Chronic Myelomonocytic Leukaemia. Ann Hematol. 2011;90(3):307-13.

Lange C, Brunswig-Spickenheier B, Cappallo-Obermann H, Eggert K, Gehling UM, Rudolph C, Schlegelberger B, Cornils K, Zustin J, Spiess AN, Zander AR. Radiation Rescue: Mesenchymal Stromal Cells Protect from Lethal Irradiation. PLoS One. 2011;6(1):e14486.

Galla M, Schambach A, Falk CS, Maetzig T, Kuehle J, Lange K, Zychlinski D, Heinz N, Brugman MH, Gohring G, Izsvak Z, Ivics Z, Baum C. Avoiding Cytotoxicity of Transposases by Dose-Controlled Mrna Delivery. Nucleic Acids Res. 2011;39(16):7147-60.

Wagner K, Damm F, Thol F, Gohring G, Gorlich K, Heuser M, Schafer I, Schlegelberger B, Heil G, Ganser A, Krauter J. Flt3-Internal Tandem Duplication and Age Are the Major Prognostic Factors in Patients with Relapsed Acute Myeloid Leukemia with Normal Karyotype. Haematologica. 2011;96(5):681-6.

Jadersten M, Saft L, Smith A, Kulasekararaj A, Pomplun S, Gohring G, Hedlund A, Hast R, Schlegelberger B, Porwit A, Hellstrom-Lindberg E, Mufti GJ. Tp53 Mutations in Low-Risk Myelodysplastic Syndromes with Del(5q) Predict Disease Progression. J Clin Oncol. 2011;29(15):1971-9.

Otto N, Manukjan G, Gohring G, Hofmann W, Scherer R, Luna JC, Lehmann U, Ganser A, Welte K, Schlegelberger B, Steinemann D. Icsbp Promoter Methylation in Myelodysplastic Syndromes and Acute Myeloid Leukaemia. Leukemia. 2011;25(7):1202-7.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011;9(7):e1001099. Epub 2011/07/19.

Hussein K, Horny HP, Busche G, Gorner M, Gohring G, Kreipe H, Bock O. Systemic Mastocytosis (Sm) with Associated Bcr-Abl-Positive Myelogenous Leukaemia (Sm-Ahnmd): Evidence That Mast Cells Do Not Belong to the Leukaemic Clone. Leukemia. 2011;25(6):1050-3. Epub 2011/03/30.

Thol F, Friesen I, Damm F, Yun H, Weissinger EM, Krauter J, Wagner K, Chaturvedi A, Sharma A, Wichmann M, Gohring G, Schumann C, Bug G, Ottmann O, Hofmann WK, Schlegelberger B, Heuser M, Ganser A. Prognostic Significance of Asxl1 Mutations in Patients with Myelodysplastic Syndromes. J Clin Oncol. 2011;29(18):2499-506.

Damm F, Oberacker T, Thol F, Surdziel E, Wagner K, Chaturvedi A, Morgan M, Bomm K, Gohring G, Lubbert M, Kanz L, Fiedler W, Schlegelberger B, Heil G, Schlenk RF, Dohner K, Dohner H, Krauter J, Ganser A, Heuser M. Prognostic Importance of Histone Methyltransferase Mll5 Expression in Acute Myeloid Leukemia. J Clin Oncol. 2011;29(6):682-9.

Ripperger T, Tauscher M, Haase D, Griesinger F, Schlegelberger B, Steinemann D. Managing Individuals with Propensity to Myeloid Malignancies Due to Germline Runx1 Deficiency. Haematologica. 2011;96(12):1892-4.

Fabarius A, Leitner A, Hochhaus A, Muller MC, Hanfstein B, Haferlach C, Gohring G, Schlegelberger B, Jotterand M, Reiter A, Jung-Munkwitz S, Proetel U, Schwaab J, Hofmann WK, Schubert J, Einsele H, Ho AD, Falge C, Kanz L, Neubauer A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Baerlocher GM, Lauseker M, Pfirrmann M, Hasford J, Saussele S, Hehlmann R. Impact of Additional Cytogenetic Aberrations at Diagnosis on Prognosis of Cml: Long-Term Observation of 1151 Patients from the Randomized Cml Study Iv. Blood. 2011;118(26):6760-8. Epub 2011/11/01.

Kayser S, Dohner K, Krauter J, Kohne CH, Horst HA, Held G, von Lilienfeld-Toal M, Wilhelm S, Kundgen A, Gotze K, Rummel M, Nachbaur D, Schlegelberger B, Gohring G, Spath D, Morlok C, Zucknick M, Ganser A, Dohner H, Schlenk RF, German-Austrian A. The Impact of Therapy-Related Acute Myeloid Leukemia (Aml) on Outcome in 2853 Adult Patients with Newly Diagnosed Aml. Blood. 2011;117(7):2137-45.

Ripperger T, Tauscher M, Praulich I, Pabst B, Teigler-Schlegel A, Yeoh A, Gohring G, Schlegelberger B, Flotho C, Niemeyer CM, Steinemann D. Constitutional Trisomy 8p11.21-Q11.21 Mosaicism: A Germline Alteration Predisposing to Myeloid Leukaemia. Br J Haematol. 2011;155(2):209-17.

Malaise M, Neumeier M, Botteron C, Dohner K, Reinhardt D, Schlegelberger B, Gohring G, Gruhn B, Debatin KM, Corbacioglu S. Stable and Reproducible Engraftment of Primary Adult and Pediatric Acute Myeloid Leukemia in Nsg Mice. Leukemia. 2011;25(10):1635-9.

Thol F, Damm F, Ludeking A, Winschel C, Wagner K, Morgan M, Yun H, Gohring G, Schlegelberger B, Hoelzer D, Lubbert M, Kanz L, Fiedler W, Kirchner H, Heil G, Krauter J, Ganser A, Heuser M. Incidence and Prognostic Influence of Dnmt3a Mutations in Acute Myeloid Leukemia. J Clin Oncol. 2011;29(21):2889-96.

Kronke J, Schlenk RF, Jensen KO, Tschurtz F, Corbacioglu A, Gaidzik VI, Paschka P, Onken S, Eiwen K, Habdank M, Spath D, Lubbert M, Wattad M, Kindler T, Salih HR, Held G, Nachbaur D, von Lilienfeld-Toal M, Germing U, Haase D, Mergenthaler HG, Krauter J, Ganser A, Gohring G, Schlegelberger B, Dohner H, Dohner K. Monitoring of Minimal Residual Disease in Npm1-Mutated Acute Myeloid Leukemia: A Study from the German-Austrian Acute Myeloid Leukemia Study Group. J Clin Oncol. 2011;29(19):2709-16.

Gohring G, Giagounidis A, Busche G, Hofmann W, Kreipe HH, Fenaux P, Hellstrom-Lindberg E, Schlegelberger B. Cytogenetic Follow-up by Karyotyping and Fluorescence in Situ Hybridization: Implications for Monitoring Patients with Myelodysplastic Syndrome and Deletion 5q Treated with Lenalidomide. Haematologica. 2011;96(2):319-22.

Chen Q, Shi X, Rudolph C, Yu Y, Zhang D, Zhao X, Mai S, Wang G, Schlegelberger B, Shi Q. Recurrent Trisomy and Robertsonian Translocation of Chromosome 14 in Murine Ips Cell Lines. Chromosome Res. 2011;19(7):857-68.

2010

Damm F, Heuser M, Morgan M, Yun H, Grosshennig A, Gohring G, Schlegelberger B, Dohner K, Ottmann O, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Dohner H, Heil G, Ganser A, Krauter J. Single Nucleotide Polymorphism in the Mutational Hotspot of Wt1 Predicts a Favorable Outcome in Patients with Cytogenetically Normal Acute Myeloid Leukemia. J Clin Oncol. 2010;28(4):578-85.

Praulich I, Tauscher M, Gohring G, Glaser S, Hofmann W, Feurstein S, Flotho C, Lichter P, Niemeyer CM, Schlegelberger B, Steinemann D. Clonal Heterogeneity in Childhood Myelodysplastic Syndromes--Challenge for the Detection of Chromosomal Imbalances by Array-Cgh. Genes Chromosomes Cancer. 2010;49(10):885-900.

Hussein K, Theophile K, Busche G, Schlegelberger B, Gohring G, Kreipe H, Bock O. Aberrant Microrna Expression Pattern in Myelodysplastic Bone Marrow Cells. Leuk Res. 2010;34(9):1169-74.

Potapova A, Hasemeier B, Romermann D, Metzig K, Gohring G, Schlegelberger B, Langer F, Kreipe H, Lehmann U. Epigenetic Inactivation of Tumour Suppressor Gene Klf11 in Myelodysplastic Syndromes*. Eur J Haematol. 2010;84(4):298-303.

Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, Schmidt M, Kramer A, Schwable J, Glimm H, Koehl U, Preiss C, Ball C, Martin H, Gohring G, Schwarzwaelder K, Hofmann WK, Karakaya K, Tchatchou S, Yang R, Reinecke P, Kuhlcke K, Schlegelberger B, Thrasher AJ, Hoelzer D, Seger R, von Kalle C, Grez M. Genomic Instability and Myelodysplasia with Monosomy 7 Consequent to Evi1 Activation after Gene Therapy for Chronic Granulomatous Disease. Nat Med. 2010;16(2):198-204.

Damm F, Lange K, Heuser M, Oberacker T, Morgan M, Wagner K, Krauter J, Schlegelberger B, Ganser A, Gohring G. Phosphoinositide Phospholipase Cbeta1 (Pi-Plcbeta1) Gene in Myelodysplastic Syndromes and Cytogenetically Normal Acute Myeloid Leukemia: Not a Deletion, but Increased Pi-Plcbeta1 Expression Is an Independent Prognostic Factor. J Clin Oncol. 2010;28(22):e384-7; author reply e8-9. Epub 2010/06/03.

Wessels K, Bohnhorst B, Luhmer I, Morlot S, Bohring A, Jonasson J, Epplen JT, Gadzicki D, Glaser S, Gohring G, Malzer M, Hein A, Arslan-Kirchner M, Stuhrmann M, Schmidtke J, Pabst B. Novel Chd7 Mutations Contributing to the Mutation Spectrum in Patients with Charge Syndrome. Eur J Med Genet. 2010;53(5):280-5.

Gohring G, Giagounidis A, Busche G, Kreipe HH, Zimmermann M, Hellstrom-Lindberg E, Aul C, Schlegelberger B. Patients with Del(5q) Mds Who Fail to Achieve Sustained Erythroid or Cytogenetic Remission after Treatment with Lenalidomide Have an Increased Risk for Clonal Evolution and Aml Progression. Ann Hematol. 2010;89(4):365-74. Epub 2009/10/27.

Tehranchi R, Woll PS, Anderson K, Buza-Vidas N, Mizukami T, Mead AJ, Astrand-Grundstrom I, Strombeck B, Horvat A, Ferry H, Dhanda RS, Hast R, Ryden T, Vyas P, Gohring G, Schlegelberger B, Johansson B, Hellstrom-Lindberg E, List A, Nilsson L, Jacobsen SE. Persistent Malignant Stem Cells in Del(5q) Myelodysplasia in Remission. N Engl J Med. 2010;363(11):1025-37.

Nowak-Imialek M, Kues WA, Rudolph C, Schlegelberger B, Taylor U, Carnwath JW, Niemann H. Preferential Loss of Porcine Chromosomes in Reprogrammed Interspecies Cell Hybrids. Cell Reprogram. 2010;12(1):55-65.

Thol F, Damm F, Wagner K, Gohring G, Schlegelberger B, Hoelzer D, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Heil G, Heuser M, Krauter J, Ganser A. Prognostic Impact of Idh2 Mutations in Cytogenetically Normal Acute Myeloid Leukemia. Blood. 2010;116(4):614-6.

Lange K, Gadzicki D, Schlegelberger B, Gohring G. Recurrent Involvement of Heterochromatic Regions in Multiple Myeloma-a Multicolor Fish Study. Leuk Res. 2010;34(8):1002-6.

Gohring G, Michalova K, Beverloo HB, Betts D, Harbott J, Haas OA, Kerndrup G, Sainati L, Bergstraesser E, Hasle H, Stary J, Trebo M, van den Heuvel-Eibrink MM, Zecca M, van Wering ER, Fischer A, Noellke P, Strahm B, Locatelli F, Niemeyer CM, Schlegelberger B. Complex Karyotype Newly Defined: The Strongest Prognostic Factor in Advanced Childhood Myelodysplastic Syndrome. Blood. 2010;116(19):3766-9.

Koenecke C, Kumpers P, Lukasz A, Dammann E, Verhagen W, Gohring G, Buchholz S, Krauter J, Eder M, Schlegelberger B, Ganser A. Shedding of the Endothelial Receptor Tyrosine Kinase Tie2 Correlates with Leukemic Blast Burden and Outcome after Allogeneic Hematopoietic Stem Cell Transplantation for Aml. Ann Hematol. 2010;89(5):459-67.

Hussein K, Theophile K, Busche G, Schlegelberger B, Gohring G, Kreipe H, Bock O. Significant Inverse Correlation of Microrna-150/Myb and Microrna-222/P27 in Myelodysplastic Syndrome. Leuk Res. 2010;34(3):328-34.

Wagner K, Damm F, Gohring G, Gorlich K, Heuser M, Schafer I, Ottmann O, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar AA, Fiedler W, Kirchner HH, Brugger W, Zucknick M, Schlegelberger B, Heil G, Ganser A, Krauter J. Impact of Idh1 R132 Mutations and an Idh1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: Snp Rs11554137 Is an Adverse Prognostic Factor. J Clin Oncol. 2010;28(14):2356-64. Epub 2010/04/07.

Thol F, Weissinger EM, Krauter J, Wagner K, Damm F, Wichmann M, Gohring G, Schumann C, Bug G, Ottmann O, Hofmann WK, Schlegelberger B, Ganser A, Heuser M. Idh1 Mutations in Patients with Myelodysplastic Syndromes Are Associated with an Unfavorable Prognosis. Haematologica. 2010;95(10):1668-74.

Lange K, Holm L, Vang Nielsen K, Hahn A, Hofmann W, Kreipe H, Schlegelberger B, Gohring G. Telomere Shortening and Chromosomal Instability in Myelodysplastic Syndromes. Genes Chromosomes Cancer. 2010;49(3):260-9.

2009

Li Z, Beutel G, Rhein M, Meyer J, Koenecke C, Neumann T, Yang M, Krauter J, von Neuhoff N, Heuser M, Diedrich H, Gohring G, Wilkens L, Schlegelberger B, Ganser A, Baum C. High-Affinity Neurotrophin Receptors and Ligands Promote Leukemogenesis. Blood. 2009;113(9):2028-37.

Steinemann D, Praulich I, Otto N, Gohring G, Niemeyer CM, Schlegelberger B. Mutation Analysis of the Hax1 Gene in Childhood Myelodysplastic Syndrome. Br J Haematol. 2009;145(4):533-4.

Ripperger T, Steinemann D, Gohring G, Finke J, Niemeyer CM, Strahm B, Schlegelberger B. A Novel Pedigree with Heterozygous Germline Runx1 Mutation Causing Familial Mds-Related Aml: Can These Families Serve as a Multistep Model for Leukemic Transformation? Leukemia. 2009;23(7):1364-6. Epub 2009/04/24.

Koenigsmann J, Rudolph C, Sander S, Kershaw O, Gruber AD, Bullinger L, Schlegelberger B, Carstanjen D. Nf1 Haploinsufficiency and Icsbp Deficiency Synergize in the Development of Leukemias. Blood. 2009;113(19):4690-701.

Rudolph C, Schlegelberger B. Spectral Karyotyping and Fluorescence in Situ Hybridization of Murine Cells. Methods Mol Biol. 2009;506:453-66.

Christgen M, Bruchhardt H, Hadamitzky C, Rudolph C, Steinemann D, Gadzicki D, Hasemeier B, Romermann D, Focken T, Krech T, Ballmaier M, Schlegelberger B, Kreipe H, Lehmann U. Comprehensive Genetic and Functional Characterization of Iph-926: A Novel Cdh1-Null Tumour Cell Line from Human Lobular Breast Cancer. J Pathol. 2009;217(5):620-32.

Jadersten M, Saft L, Pellagatti A, Gohring G, Wainscoat JS, Boultwood J, Porwit A, Schlegelberger B, Hellstrom-Lindberg E. Clonal Heterogeneity in the 5q- Syndrome: P53 Expressing Progenitors Prevail During Lenalidomide Treatment and Expand at Disease Progression. Haematologica. 2009;94(12):1762-6. Epub 2009/10/03.

Hussein K, Bock O, Theophile K, Schlue J, Ballmaier M, Kroger N, Gohring G, Busche G, Kreipe H. Biclonal Expansion and Heterogeneous Lineage Involvement in a Case of Chronic Myeloproliferative Disease with Concurrent Mplw515l/Jak2v617f Mutation. Blood. 2009;113(6):1391-2.

2008

Kumpers P, Koenecke C, Hecker H, Hellpap J, Horn R, Verhagen W, Buchholz S, Hertenstein B, Krauter J, Eder M, David S, Gohring G, Haller H, Ganser A. Angiopoietin-2 Predicts Disease-Free Survival after Allogeneic Stem Cell Transplantation in Patients with High-Risk Myeloid Malignancies. Blood. 2008;112(5):2139-48.

Buesche G, Teoman H, Wilczak W, Ganser A, Hecker H, Wilkens L, Gohring G, Schlegelberger B, Bock O, Georgii A, Kreipe H. Marrow Fibrosis Predicts Early Fatal Marrow Failure in Patients with Myelodysplastic Syndromes. Leukemia. 2008;22(2):313-22.

Romermann D, Hasemeier B, Metzig K, Gohring G, Schlegelberger B, Langer F, Kreipe H, Lehmann U. Global Increase in DNA Methylation in Patients with Myelodysplastic Syndrome. Leukemia. 2008;22(10):1954-6.

Modlich U, Schambach A, Brugman MH, Wicke DC, Knoess S, Li Z, Maetzig T, Rudolph C, Schlegelberger B, Baum C. Leukemia Induction after a Single Retroviral Vector Insertion in Evi1 or Prdm16. Leukemia. 2008;22(8):1519-28.

Chao MM, Kontny U, Brink I, Gohring G, Schmitt-Graff A, Rister M, Strahm B. Extramedullary Relapse of Therapy-Related Myelodysplastic Syndrome after Donor Leukocyte Infusion. Ann Hematol. 2008;87(2):165-6.

Templin C, Kotlarz D, Rathinam C, Rudolph C, Schatzlein S, Ramireddy K, Rudolph KL, Schlegelberger B, Klein C, Drexler H. Establishment of Immortalized Multipotent Hematopoietic Progenitor Cell Lines by Retroviral-Mediated Gene Transfer of Beta-Catenin. Exp Hematol. 2008;36(2):204-15.

Steinemann D, Cario G, Stanulla M, Karawajew L, Tauscher M, Weigmann A, Gohring G, Ludwig WD, Harbott J, Radlwimmer B, Bartram C, Lichter P, Schrappe M, Schlegelberger B. Copy Number Alterations in Childhood Acute Lymphoblastic Leukemia and Their Association with Minimal Residual Disease. Genes Chromosomes Cancer. 2008;47(6):471-80. Epub 2008/03/04.

Staboulidou I, Miller K, Gohring G, Hillemanns P, Wustemann M. Prenatal Diagnosis of an Epignathus Associated with a 49,Xxxxy Karyotype--a Case Report. Fetal Diagn Ther. 2008;24(3):313-7.

2007

Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, Reeves L, Williams DA. Importance of Murine Study Design for Testing Toxicity of Retroviral Vectors in Support of Phase I Trials. Mol Ther. 2007;15(4):782-91.

Giagounidis AA, Haase S, Heinsch M, Gohring G, Schlegelberger B, Aul C. Lenalidomide in the Context of Complex Karyotype or Interrupted Treatment: Case Reviews of Del(5q)Mds Patients with Unexpected Responses. Ann Hematol. 2007;86(2):133-7.

Hussein K, Bock O, Ballmaier M, Gohring G, Steinemann D, Lehmann U, Kemper J, Buhr T, Kreipe H. Familial Polycythemia Vera with Non-Germline Jak2(V617f) Mutation Sparing the Abnormal and Clonal Granulopoiesis. Leukemia. 2007;21(12):2566-8.

Ripperger T, von Neuhoff N, Kamphues K, Emura M, Lehmann U, Tauscher M, Schraders M, Groenen P, Skawran B, Rudolph C, Callet-Bauchu E, van Krieken JH, Schlegelberger B, Steinemann D. Promoter Methylation of Parg1, a Novel Candidate Tumor Suppressor Gene in Mantle-Cell Lymphomas. Haematologica. 2007;92(4):460-8.

Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, Rudolph C, Kuhnel F, Wei K, Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice. Cell. 2007;130(5):863-77.

Meyer J, Rhein M, Schiedlmeier B, Kustikova O, Rudolph C, Kamino K, Neumann T, Yang M, Wahlers A, Fehse B, Reuther GW, Schlegelberger B, Ganser A, Baum C, Li Z. Remarkable Leukemogenic Potency and Quality of a Constitutively Active Neurotrophin Receptor, Deltatrka. Leukemia. 2007;21(10):2171-80.

Gohring G, Lange K, Atta J, Krauter J, Holzer D, Schlegelberger B. Cryptic T(15;17) in a Patient with Aml M3 and a Complex Karyotype. Cancer Genet Cytogenet. 2007;175(1):77-80. Epub 2007/05/15.

Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, Schlenk RF, Dohner K, Hinrichsen T, Rudolph C, Schambach A, Baum C, Schlegelberger B, Dohner H, Ganser A, Humphries RK. Mn1 Overexpression Induces Acute Myeloid Leukemia in Mice and Predicts Atra Resistance in Patients with Aml. Blood. 2007;110(5):1639-47.

Gohring G, Erlacher M, van Buiren M, Juttner E, Niemeyer CM, Schlegelberger B. Mesenteric Chloroma with T(16;16) Followed by Acute Myelomonocytic Leukemia with Clonal Evolution. Cancer Genet Cytogenet. 2007;179(2):162-4.

Reimann M, Loddenkemper C, Rudolph C, Schildhauer I, Teichmann B, Stein H, Schlegelberger B, Dorken B, Schmitt CA. The Myc-Evoked DNA Damage Response Accounts for Treatment Resistance in Primary Lymphomas in Vivo. Blood. 2007;110(8):2996-3004.

Karow A, Steinemann D, Gohring G, Hasle H, Greiner J, Harila-Saari A, Flotho C, Zenker M, Schlegelberger B, Niemeyer CM, Kratz CP. Clonal Duplication of a Germline Ptpn11 Mutation Due to Acquired Uniparental Disomy in Acute Lymphoblastic Leukemia Blasts from a Patient with Noonan Syndrome. Leukemia. 2007;21(6):1303-5. Epub 2007/03/16.

Gohring G, Karow A, Steinemann D, Wilkens L, Lichter P, Zeidler C, Niemeyer C, Welte K, Schlegelberger B. Chromosomal Aberrations in Congenital Bone Marrow Failure Disorders--an Early Indicator for Leukemogenesis? Ann Hematol. 2007;86(10):733-9.

2006

Gohring G, Hanke C, Kratz C, Kontny U, Steinemann D, Niemeyer CM, Schlegelberger B. Fluorescence in Situ Hybridization Using the Subtelomeric 11q Probe as a Diagnostic Tool for Congenital Thrombocytopenia. Ann Hematol. 2006;85(12):883-5. Epub 2006/09/16.

Hussein K, Brakensiek K, Ballmaier M, Bormann M, Gohring G, Buhr T, Bock O, Kreipe H. B-Cll Developing in a Patient with Pv Is Not Affected by V617f Mutation of the Janus Kinase 2. Eur J Haematol. 2006;77(6):539-41. Epub 2006/11/16.

2003

Warmann S, Gohring G, Teichmann B, Geerlings H, Pietsch T, Fuchs J. P-Glycoprotein Modulation Improves in Vitro Chemosensitivity in Malignant Pediatric Liver Tumors. Anticancer Res. 2003;23(6C):4607-11.

2002

Warmann S, Gohring G, Teichmann B, Geerlings H, Fuchs J. Mdr1 Modulators Improve the Chemotherapy Response of Human Hepatoblastoma to Doxorubicin in Vitro. J Pediatr Surg. 2002;37(11):1579-84.

Unit 9.6 - Genomic Profiling

2016

Thiesler CT, Cajic S, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weibetamann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Korner C, Schambach A, Rapp E, Buettner FF. Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG). Molecular & cellular proteomics : MCP. 2016;15(4):1435-52.

Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Putzer BM, Arauzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Scholer HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell stem cell. 2016;18(6):797-808.

Ripperger T, Tawana K, Kratz C, Schlegelberger B, Fitzgibbon J, Steinemann D. Clinical utility gene card for: Familial platelet disorder with associated myeloid malignancies. Eur J Hum Genet. 2016;24(8).

Manukjan G, Ripperger T, Venturini L, Stadler M, Gohring G, Schambach A, Schlegelberger B, Steinemann D. GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. Stem cell research. 2016;16(3):677-81.

Eggenschwiler R, Moslem M, Fraguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wahner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Scientific reports. 2016;6:38198.

Christgen M, van Luttikhuizen JL, Raap M, Braubach P, Schmidt L, Jonigk D, Feuerhake F, Lehmann U, Schlegelberger B, Kreipe HH, Steinemann D. Precise ERBB2 copy number assessment in breast cancer by means of molecular inversion probe array analysis. Oncotarget. 2016;7(50):82733-40.

2015

Begay V, Smink JJ, Loddenkemper C, Zimmermann K, Rudolph C, Scheller M, Steinemann D, Leser U, Schlegelberger B, Stein H, Leutz A. Deregulation of the Endogenous C/Ebpbeta Lip Isoform Predisposes to Tumorigenesis. J Mol Med (Berl). 2015;93(1):39-49. Epub 2014/11/18.

Peterlongo P, Chang-Claude J, Moysich KB, Rudolph A, Schmutzler RK, Simard J, Soucy P, Eeles RA, Easton DF, Hamann U, Wilkening S, Chen B, Rookus MA, Schmidt MK, van der Baan FH, Spurdle AB, Walker LC, Lose F, Maia AT, Montagna M, Matricardi L, Lubinski J, Jakubowska A, Gomez Garcia EB, Olopade OI, Nussbaum RL, Nathanson KL, Domchek SM, Rebbeck TR, Arun BK, Karlan BY, Orsulic S, Lester J, Chung WK, Miron A, Southey MC, Goldgar DE, Buys SS, Janavicius R, Dorfling CM, van Rensburg EJ, Ding YC, Neuhausen SL, Hansen TV, Gerdes AM, Ejlertsen B, Jonson L, Osorio A, Martinez-Bouzas C, Benitez J, Conway EE, Blazer KR, Weitzel JN, Manoukian S, Peissel B, Zaffaroni D, Scuvera G, Barile M, Ficarazzi F, Mariette F, Fortuzzi S, Viel A, Giannini G, Papi L, Martayan A, Tibiletti MG, Radice P, Vratimos A, Fostira F, Garber JE, Donaldson A, Brewer C, Foo C, Evans DG, Frost D, Eccles D, Brady A, Cook J, Tischkowitz M, Adlard J, Barwell J, Walker L, Izatt L, Side LE, Kennedy MJ, Rogers MT, Porteous ME, Morrison PJ, Platte R, Davidson R, Hodgson SV, Ellis S, Cole T, Godwin AK, Claes K, Van Maerken T, Meindl A, Gehrig A, Sutter C, Engel C, Niederacher D, Steinemann D, Plendl H, Kast K, Rhiem K, Ditsch N, Arnold N, Varon-Mateeva R, Wappenschmidt B, Wang-Gohrke S, Bressac-de Paillerets B, Buecher B, Delnatte C, Houdayer C, Stoppa-Lyonnet D, Damiola F, Coupier I, Barjhoux L, Venat-Bouvet L, Golmard L, Boutry-Kryza N, Sinilnikova OM, Caron O, Pujol P, Mazoyer S, Belotti M, Piedmonte M, Friedlander ML, Rodriguez GC, Copeland LJ, de la Hoya M, Segura PP, Nevanlinna H, Aittomaki K, van Os TA, Meijers-Heijboer HE, van der Hout AH, Vreeswijk MP, Hoogerbrugge N, Ausems MG, van Doorn HC, Collee JM, Olah E, Diez O, Blanco I, Lazaro C, Brunet J, Feliubadalo L, Cybulski C, Gronwald J, Durda K, Jaworska-Bieniek K, Sukiennicki G, Arason A, Chiquette J, Teixeira MR, Olswold C, Couch FJ, Lindor NM, Wang X, Szabo CI, Offit K, Corines M, Jacobs L, Robson ME, Zhang L, Joseph V, Berger A, Singer CF, Rappaport C, Kaulich DG, Pfeiler G, Tea MK, Phelan CM, Greene MH, Mai PL, Rennert G, Mulligan AM, Glendon G, Tchatchou S, Andrulis IL, Toland AE, Bojesen A, Pedersen IS, Thomassen M, Jensen UB, Laitman Y, Rantala J, von Wachenfeldt A, Ehrencrona H, Askmalm MS, Borg A, Kuchenbaecker KB, McGuffog L, Barrowdale D, Healey S, Lee A, Pharoah PD, Chenevix-Trench G, Antoniou AC, Friedman E. Candidate Genetic Modifiers for Breast and Ovarian Cancer Risk in Brca1 and Brca2 Mutation Carriers. Cancer Epidemiol Biomarkers Prev. 2015;24(1):308-16. Epub 2014/10/23.

Schlegelberger B, Kreipe H, Lehmann U, Steinemann D, Ripperger T, Gohring G, Thomay K, Rump A, Di Donato N, Suttorp M. A Child with Li-Fraumeni Syndrome: Modes to Inactivate the Second Allele of Tp53 in Three Different Malignancies. Pediatr Blood Cancer. 2015;62(8):1481-4. Epub 2015/03/20.

Roessler J, Ammerpohl O, Gutwein J, Steinemann D, Schlegelberger B, Weyer V, Sariyar M, Geffers R, Arnold N, Schmutzler R, Bartram CR, Heinrich T, Abbas M, Antonopoulos W, Schipper E, Hasemeier B, Kreipe H, Lehmann U. The Cpg Island Methylator Phenotype in Breast Cancer Is Associated with the Lobular Subtype. Epigenomics. 2015;7(2):187-99. Epub 2014/10/28.

Manukjan G, Ripperger T, Santer L, von Neuhoff N, Ganser A, Schambach A, Schlegelberger B, Steinemann D. Expression of the Ets Transcription Factor Gabpalpha Is Positively Correlated to the Bcr-Abl1/Abl1 Ratio in Cml Patients and Affects Imatinib Sensitivity in Vitro. Exp Hematol. 2015;43(10):880-90. Epub 2015/06/15.

Moog U, Bierhals T, Brand K, Bautsch J, Biskup S, Brune T, Denecke J, de Die-Smulders CE, Evers C, Hempel M, Henneke M, Yntema H, Menten B, Pietz J, Pfundt R, Schmidtke J, Steinemann D, Stumpel CT, Van Maldergem L, Kutsche K. Phenotypic and Molecular Insights into Cask-Related Disorders in Males. Orphanet J Rare Dis. 2015;10:44. Epub 2015/04/18.

Ripperger T, Manukjan G, Meyer J, Wolter S, Schambach A, Bohne J, Modlich U, Li Z, Skawran B, Schlegelberger B, Steinemann D. The Heteromeric Transcription Factor Gabp Activates the Itgam/Cd11b Promoter and Induces Myeloid Differentiation. Biochim Biophys Acta. 2015;1849(9):1145-54. Epub 2015/07/15.

Schwarzer A, Holtmann H, Brugman M, Meyer J, Schauerte C, Zuber J, Steinemann D, Schlegelberger B, Li Z, Baum C. Hyperactivation of Mtorc1 and Mtorc2 by Multiple Oncogenic Events Causes Addiction to Eif4e-Dependent Mrna Translation in T-Cell Leukemia. Oncogene. 2015;34(27):3593-604. Epub 2014/09/23.

Dreyer AK, Hoffmann D, Lachmann N, Ackermann M, Steinemann D, Timm B, Siler U, Reichenbach J, Grez M, Moritz T, Schambach A, Cathomen T. Talen-Mediated Functional Correction of X-Linked Chronic Granulomatous Disease in Patient-Derived Induced Pluripotent Stem Cells. Biomaterials. 2015;69:191-200. Epub 2015/08/22.

2014

Schott JW, Hoffmann D, Maetzig T, Muller FJ, Steinemann D, Zychlinski D, Cantz T, Baum C, Schambach A. Improved Retroviral Episome Transfer of Transcription Factors Enables Sustained Cell Fate Modification. Gene Ther. 2014;21(11):938-49. Epub 2014/08/08.

Skokowa J, Steinemann D, Katsman-Kuipers JE, Zeidler C, Klimenkova O, Klimiankou M, Unalan M, Kandabarau S, Makaryan V, Beekman R, Behrens K, Stocking C, Obenauer J, Schnittger S, Kohlmann A, Valkhof MG, Hoogenboezem R, Gohring G, Reinhardt D, Schlegelberger B, Stanulla M, Vandenberghe P, Donadieu J, Zwaan CM, Touw IP, van den Heuvel-Eibrink MM, Dale DC, Welte K. Cooperativity of Runx1 and Csf3r Mutations in Severe Congenital Neutropenia: A Unique Pathway in Myeloid Leukemogenesis. Blood. 2014;123(14):2229-37.

Osorio A, Milne RL, Kuchenbaecker K, Vaclova T, Pita G, Alonso R, Peterlongo P, Blanco I, de la Hoya M, Duran M, Diez O, Ramon YCT, Konstantopoulou I, Martinez-Bouzas C, Andres Conejero R, Soucy P, McGuffog L, Barrowdale D, Lee A, Swe B, Arver B, Rantala J, Loman N, Ehrencrona H, Olopade OI, Beattie MS, Domchek SM, Nathanson K, Rebbeck TR, Arun BK, Karlan BY, Walsh C, Lester J, John EM, Whittemore AS, Daly MB, Southey M, Hopper J, Terry MB, Buys SS, Janavicius R, Dorfling CM, van Rensburg EJ, Steele L, Neuhausen SL, Ding YC, Hansen TV, Jonson L, Ejlertsen B, Gerdes AM, Infante M, Herraez B, Moreno LT, Weitzel JN, Herzog J, Weeman K, Manoukian S, Peissel B, Zaffaroni D, Scuvera G, Bonanni B, Mariette F, Volorio S, Viel A, Varesco L, Papi L, Ottini L, Tibiletti MG, Radice P, Yannoukakos D, Garber J, Ellis S, Frost D, Platte R, Fineberg E, Evans G, Lalloo F, Izatt L, Eeles R, Adlard J, Davidson R, Cole T, Eccles D, Cook J, Hodgson S, Brewer C, Tischkowitz M, Douglas F, Porteous M, Side L, Walker L, Morrison P, Donaldson A, Kennedy J, Foo C, Godwin AK, Schmutzler RK, Wappenschmidt B, Rhiem K, Engel C, Meindl A, Ditsch N, Arnold N, Plendl HJ, Niederacher D, Sutter C, Wang-Gohrke S, Steinemann D, Preisler-Adams S, Kast K, Varon-Mateeva R, Gehrig A, Stoppa-Lyonnet D, Sinilnikova OM, Mazoyer S, Damiola F, Poppe B, Claes K, Piedmonte M, Tucker K, Backes F, Rodriguez G, Brewster W, Wakeley K, Rutherford T, Caldes T, Nevanlinna H, Aittomaki K, Rookus MA, van Os TA, van der Kolk L, de Lange JL, Meijers-Heijboer HE, van der Hout AH, van Asperen CJ, Gomez Garcia EB, Hoogerbrugge N, Collee JM, van Deurzen CH, van der Luijt RB, Devilee P, Hebon, Olah E, Lazaro C, Teule A, Menendez M, Jakubowska A, Cybulski C, Gronwald J, Lubinski J, Durda K, Jaworska-Bieniek K, Johannsson OT, Maugard C, Montagna M, Tognazzo S, Teixeira MR, Healey S, Investigators K, Olswold C, Guidugli L, Lindor N, Slager S, Szabo CI, Vijai J, Robson M, Kauff N, Zhang L, Rau-Murthy R, Fink-Retter A, Singer CF, Rappaport C, Geschwantler Kaulich D, Pfeiler G, Tea MK, Berger A, Phelan CM, Greene MH, Mai PL, Lejbkowicz F, Andrulis I, Mulligan AM, Glendon G, Toland AE, Bojesen A, Pedersen IS, Sunde L, Thomassen M, Kruse TA, Jensen UB, Friedman E, Laitman Y, Shimon SP, Simard J, Easton DF, Offit K, Couch FJ, Chenevix-Trench G, Antoniou AC, Benitez J. DNA Glycosylases Involved in Base Excision Repair May Be Associated with Cancer Risk in Brca1 and Brca2 Mutation Carriers. PLoS Genet. 2014;10(4):e1004256.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82. Epub 2013/11/28.

Braun CJ, Boztug K, Paruzynski A, Witzel M, Schwarzer A, Rothe M, Modlich U, Beier R, Gohring G, Steinemann D, Fronza R, Ball CR, Haemmerle R, Naundorf S, Kuhlcke K, Rose M, Fraser C, Mathias L, Ferrari R, Abboud MR, Al-Herz W, Kondratenko I, Marodi L, Glimm H, Schlegelberger B, Schambach A, Albert MH, Schmidt M, von Kalle C, Klein C. Gene Therapy for Wiskott-Aldrich Syndrome--Long-Term Efficacy and Genotoxicity. Sci Transl Med. 2014;6(227):227ra33.

Kuehle J, Turan S, Cantz T, Hoffmann D, Suerth JD, Maetzig T, Zychlinski D, Klein C, Steinemann D, Baum C, Bode J, Schambach A. Modified Lentiviral Ltrs Allow Flp Recombinase-Mediated Cassette Exchange and in Vivo Tracing of [Ldquo]Factor-Free[Rdquo] Induced Pluripotent Stem Cells. Mol Ther. 2014;22(5):919-28.

Feurstein S, Rucker FG, Bullinger L, Hofmann W, Manukjan G, Gohring G, Lehmann U, Heuser M, Ganser A, Dohner K, Schlegelberger B, Steinemann D. Haploinsufficiency of Etv6 and Cdkn1b in Patients with Acute Myeloid Leukemia and Complex Karyotype. BMC Genomics. 2014;15:784. Epub 2014/09/13.

Braig M, Pallmann N, Preukschas M, Steinemann D, Hofmann W, Gompf A, Streichert T, Braunschweig T, Copland M, Rudolph KL, Bokemeyer C, Koschmieder S, Schuppert A, Balabanov S, Brummendorf TH. A 'Telomere-Associated Secretory Phenotype' Cooperates with Bcr-Abl to Drive Malignant Proliferation of Leukemic Cells. Leukemia. 2014;28(10):2028-39.

2013

Kustikova OS, Schwarzer A, Stahlhut M, Brugman MH, Neumann T, Yang M, Li Z, Schambach A, Heinz N, Gerdes S, Roeder I, Ha TC, Steinemann D, Schlegelberger B, Baum C. Activation of Evi1 Inhibits Cell Cycle Progression and Differentiation of Hematopoietic Progenitor Cells. Leukemia. 2013;27(5):1127-38.

Ripperger T, Tauscher M, Thomay K, Gohring G, Kraemer D, Schlegelberger B, Steinemann D. No Evidence for Itsn1 Loss in a Patient with Mental Retardation and Complex Chromosomal Rearrangements of 21q21-21q22. Leuk Res. 2013;37(6):721-3.

Didie M, Christalla P, Rubart M, Muppala V, Doker S, Unsold B, El-Armouche A, Rau T, Eschenhagen T, Schwoerer AP, Ehmke H, Schumacher U, Fuchs S, Lange C, Becker A, Tao W, Scherschel JA, Soonpaa MH, Yang T, Lin Q, Zenke M, Han DW, Scholer HR, Rudolph C, Steinemann D, Schlegelberger B, Kattman S, Witty A, Keller G, Field LJ, Zimmermann WH. Parthenogenetic Stem Cells for Tissue-Engineered Heart Repair. J Clin Invest. 2013;123(3):1285-98.

Santag S, Jager W, Karsten CB, Kati S, Pietrek M, Steinemann D, Sarek G, Ojala PM, Schulz TF. Recruitment of the Tumour Suppressor Protein P73 by Kaposi's Sarcoma Herpesvirus Latent Nuclear Antigen Contributes to the Survival of Primary Effusion Lymphoma Cells. Oncogene. 2013;32(32):3676-85.

Manukjan G, Tauscher M, Steinemann D. Replication Timing Influences DNA Copy Number Determination by Array-Cgh. Biotechniques. 2013;55(5):231-2.

Grabundzija I, Wang J, Sebe A, Erdei Z, Kajdi R, Devaraj A, Steinemann D, Szuhai K, Stein U, Cantz T, Schambach A, Baum C, Izsvak Z, Sarkadi B, Ivics Z. Sleeping Beauty Transposon-Based System for Cellular Reprogramming and Targeted Gene Insertion in Induced Pluripotent Stem Cells. Nucleic Acids Res. 2013;41(3):1829-47.

Eggenschwiler R, Loya K, Wu G, Sharma AD, Sgodda M, Zychlinski D, Herr C, Steinemann D, Teckman J, Bals R, Ott M, Schambach A, Scholer HR, Cantz T. Sustained Knockdown of a Disease-Causing Gene in Patient-Specific Induced Pluripotent Stem Cells Using Lentiviral Vector-Based Gene Therapy. Stem Cells Transl Med. 2013;2(9):641-54.

Tauscher M, Praulich I, Steinemann D. Array-Cgh in Childhood Mds. Methods Mol Biol. 2013;973:267-78.

Steinemann D, Gohring G, Schlegelberger B. Genetic Instability of Modified Stem Cells - a First Step Towards Malignant Transformation? Am J Stem Cells. 2013;2(1):39-51. Epub 2013/05/15.

2012

Penkert J, Schlegelberger B, Steinemann D, Gadzicki D. No Evidence for Breast Cancer Susceptibility Associated with Variants of Brd7, a Component of P53 and Brca1 Pathways. Fam Cancer. 2012;11(4):601-6.

Schumacher U, Nehmann N, Adam E, Mukthar D, Slotki IN, Horny HP, Flens MJ, Schlegelberger B, Steinemann D. Mdr-1-Overexpression in Ht 29 Colon Cancer Cells Grown in Scid Mice. Acta Histochem. 2012;114(6):594-602.

Yalcinkaya C, Erturk O, Tuysuz B, Yesil G, Verbeke JI, Keyser B, Stuhrmann M, Steinemann D, Sistermans EA, van der Knaap MS. A Novel Gjc2 Mutation Associated with Hypomyelination and Mullerian Agenesis Syndrome: Coincidence or a New Entity? Neuropediatrics. 2012;43(3):159-61.

Kaufmann KB, Grunder A, Hadlich T, Wehrle J, Gothwal M, Bogeska R, Seeger TS, Kayser S, Pham KB, Jutzi JS, Ganzenmuller L, Steinemann D, Schlegelberger B, Wagner JM, Jung M, Will B, Steidl U, Aumann K, Werner M, Gunther T, Schule R, Rambaldi A, Pahl HL. A Novel Murine Model of Myeloproliferative Disorders Generated by Overexpression of the Transcription Factor Nf-E2. J Exp Med. 2012;209(1):35-50.

Pauli S, Steinemann D, Dittmann K, Wienands J, Shoukier M, Moschner M, Burfeind P, Manukjan G, Gohring G, Escherich G. Occurrence of Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia in a Patient with Noonan Syndrome Carrying the Germline Ptpn11 Mutation P.E139d. Am J Med Genet A. 2012;158A(3):652-8.

Manukjan G, Tauscher M, Ripperger T, Schwarzer A, Schlegelberger B, Steinemann D. Induced G1 Phase Arrest of Fast-Dividing Cells Improves the Quality of Genomic Profiles Generated by Array-Cgh. Biotechniques. 2012;53(4):245-8.

Otte A, Gohring G, Steinemann D, Schlegelberger B, Groos S, Langer F, Kreipe HH, Schambach A, Neumann T, Hillemanns P, Park-Simon TW, Hass R. A Tumor-Derived Population (Sccoht-1) as Cellular Model for a Small Cell Ovarian Carcinoma of the Hypercalcemic Type. Int J Oncol. 2012;41(2):765-75.

Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, Knoess S, Krause J, Li Z, Schlegelberger B, Baum C, Modlich U. Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia. Mol Ther. 2012;20(6):1187-95.

2011

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011;9(7):e1001099.

Unit 10.1 - Production and Purification of Recombinant Proteins

2017

>Gieseler G, Pepelanova I, Stuckenberg L, Villain L, Nolle V, Odenthal U, Beutel S, Rinas U, Scheper T. Purification of bone morphogenetic protein-2 from refolding mixtures using mixed-mode membrane chromatography. Appl Microbiol Biot. 2017;101(1):123-30.

2016

Ulusoy M, Lavrentieva A, Walter JG, Sambale F, Green M, Stahl F, Scheper T. Evaluation of CdTe/CdS/ZnS core/shell/shell quantum dot toxicity on three-dimensional spheroid cultures. Toxicol Res-Uk. 2016;5(1):126-35.

Ulusoy M, Jonczyk R, Walter JG, Springer S, Lavrentieva A, Stahl F, Green M, Scheper T. Aqueous Synthesis of PEGylated Quantum Dots with Increased Colloidal Stability and Reduced Cytotoxicity. Bioconjug Chem. 2016;27(2):414-26.

Stamm A, Reimers K, Strauß S, Vogt P, Scheper T, Pepelanova I. In vitro wound healing assays – state of the art. BioNanoMaterials2016. p. 79.

Schneider-Barthold C, Baganz S, Wilhelmi M, Scheper T, Pepelanova I. Hydrogels based on collagen and fibrin – frontiers and applications. BioNanoMaterials2016. p. 3.

Rueda F, Cespedes MV, Sanchez-Chardi A, Seras-Franzoso J, Pesarrodona M, Ferrer-Miralles N, Vazquez E, Rinas U, Unzueta U, Mamat U, Mangues R, Garcia-Fruitos E, Villaverde A. Structural and functional features of self-assembling protein nanoparticles produced in endotoxin-free Escherichia coli. Microb Cell Fact. 2016;15:59.

Pesarrodona M, Fernandez Y, Foradada L, Sanchez-Chardi A, Conchillo-Sole O, Unzueta U, Xu Z, Roldan M, Villegas S, Ferrer-Miralles N, Schwartz S, Jr., Rinas U, Daura X, Abasolo I, Vazquez E, Villaverde A. Conformational and functional variants of CD44-targeted protein nanoparticles bio-produced in bacteria. Biofabrication. 2016;8(2):025001.

Kropp C, Kempf H, Halloin C, Robles-Diaz D, Franke A, Scheper T, Kinast K, Knorpp T, Joos TO, Haverich A, Martin U, Zweigerdt R, Olmer R. Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors. Stem cells translational medicine. 2016;5(10):1289-301.

Jonczyk R, Timur S, Scheper T, Stahl F. Development of living cell microarrays using non-contact micropipette printing. J Biotechnol. 2016;217:109-11.

Hoepfner J, Kleinsorge M, Papp O, Ackermann M, Alfken S, Rinas U, Solodenko W, Kirschning A, Sgodda M, Cantz T. Biphasic modulation of Wnt signaling supports efficient foregut endoderm formation from human pluripotent stem cells. Cell Biol Int. 2016;40(5):534-48.

Gieseler G, Pepelanova I, Meyer A, Villain L, Beutel S, Rinas U, Scheper T. Considerations on the flow configuration of membrane chromatography devices for the purification of human basic fibroblast growth factor from crude lysates. Eng Life Sci. 2016;16(8):697-705.

Friehs E, AlSalka Y, Jonczyk R, Lavrentieva A, Jochums A, Walter J-G, Stahl F, Scheper T, Bahnemann D. Toxicity, phototoxicity and biocidal activity of nanoparticles employed in photocatalysis. Journal of Photochemistry and Photobiology C: Photochemistry Reviews. 2016;29:1-28.

2015

von der Haar K, Lavrentieva A, Stahl F, Scheper T, Blume C. Lost signature: progress and failures in in vivo tracking of implanted stem cells. Appl Microbiol Biotechnol. 2015;99(23):9907-22.

Urmann K, Walter JG, Scheper T, Segal E. Label-free optical biosensors based on aptamer-functionalized porous silicon scaffolds. Anal Chem. 2015;87(3):1999-2006.

Ulusoy M, Walter JG, Lavrentieva A, Kretschmer I, Sandiford L, Le Marois A, Bongartz R, Aliuos P, Suhling K, Stahl F, Green M, Scheper T. One-pot aqueous synthesis of highly strained CdTe/CdS/ZnS nanocrystals and their interactions with cells. Rsc Adv. 2015;5(10):7485-94.

Tscheschke B, Dreimann J, von der Ruhr JW, Schmidt T, Stahl F, Just L, Scheper T. Evaluation of a new mist-chamber bioreactor for biotechnological applications. Biotechnol Bioeng. 2015;112(6):1155-64.

Shahraz A, Kopatz J, Mathy R, Kappler J, Winter D, Kapoor S, Schutza V, Scheper T, Gieselmann V, Neumann H. Anti-inflammatory activity of low molecular weight polysialic acid on human macrophages. Scientific reports. 2015;5:16800.

Seleci M, Seleci DA, Ciftci M, Demirkol DO, Stahl F, Timur S, Scheper T, Yagci Y. Nanostructured Amphiphilic Star-Hyperbranched Block Copolymers for Drug Delivery. Langmuir. 2015;31(15):4542-51.

Schax E, Lonne M, Scheper T, Belkin S, Walter JG. Aptamer-based depletion of small molecular contaminants: A case study using ochratoxin A. Biotechnol Bioproc E. 2015;20(6):1016-25.

Sarig U, Nguyen EB, Wang Y, Ting S, Bronshtein T, Sarig H, Dahan N, Gvirtz M, Reuveny S, Oh SK, Scheper T, Boey YC, Venkatraman SS, Machluf M. Pushing the envelope in tissue engineering: ex vivo production of thick vascularized cardiac extracellular matrix constructs. Tissue Eng Part A. 2015;21(9-10):1507-19.

Sambale F, Stahl F, Bahnemann D, Scheper T. In vitro toxicological nanoparticle studies under flow exposure. J Nanopart Res. 2015;17(7).

Sambale F, Lavrentieva A, Stahl F, Blume C, Stiesch M, Kasper C, Bahnemann D, Scheper T. Three dimensional spheroid cell culture for nanoparticle safety testing. J Biotechnol. 2015;205:120-9.

Ruedinger F, Lavrentieva A, Blume C, Pepelanova I, Scheper T. Hydrogels for 3D mammalian cell culture: a starting guide for laboratory practice. Appl Microbiol Biotechnol. 2015;99(2):623-36.

Mohammadi-Ostad-Kalayeh S, Schax E, Walter JG, Scheper T, Hermane J, Kirschning A, Borges JC, Zeilinger C. Targetomics, microarray-based screening for the identification of new drugs against Leishmania braziliensis. Febs J. 2015;282:272-.

Lücking TH, Sambale F, Schnaars B, Bulnes-Abundis D, Beutel S, Scheper T. 3D-printed individual labware in biosciences by rapid prototyping: In vitro biocompatibility and applications for eukaryotic cell cultures. Eng Life Sci. 2015;15(1):57-64.

Lucking TH, Sambale F, Beutel S, Scheper T. 3D-printed individual labware in biosciences by rapid prototyping: A proof of principle. Eng Life Sci. 2015;15(1):51-6.

Lönne M, Bolten S, Lavrentieva A, Stahl F, Scheper T, Walter J-G. Development of an aptamer-based affinity purification method for vascular endothelial growth factor. Biotechnology Reports. 2015;8:16-23.

Hermane J, Bulyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A. New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90. Chembiochem. 2015;16(2):302-11.

Heilkenbrinker A, Reinemann C, Stoltenburg R, Walter JG, Jochums A, Stahl F, Zimmermann S, Strehlitz B, Scheper T. Identification of the target binding site of ethanolamine-binding aptamers and its exploitation for ethanolamine detection. Anal Chem. 2015;87(1):677-85.

Zahid M, Lunsdorf H, Rinas U. Assessing Stability and Assembly of the Hepatitis B Surface Antigen into Virus-Like Particles During Down-Stream Processing. Vaccine. 2015;33(31):3739-45. Epub 2015/06/17.

Tscheschke B, Dreimann J, von der Ruhr JW, Schmidt T, Stahl F, Just L, Scheper T. Evaluation of a New Mist-Chamber Bioreactor for Biotechnological Applications. Biotechnol Bioeng. 2015;112(6):1155-64. Epub 2014/12/30.

Sarig U, Nguyen EB, Wang Y, Ting S, Bronshtein T, Sarig H, Dahan N, Gvirtz M, Reuveny S, Oh SK, Scheper T, Boey YC, Venkatraman SS, Machluf M. Pushing the Envelope in Tissue Engineering: Ex Vivo Production of Thick Vascularized Cardiac Extracellular Matrix Constructs. Tissue Eng Part A. 2015;21(9-10):1507-19.

Lönne M, Bolten S, Lavrentieva A, Stahl F, Scheper T, Walter J-G. Development of an Aptamer-Based Affinity Purification Method for Vascular Endothelial Growth Factor. Biotechnology Reports. 2015;8:16-23.

Hermane J, Bulyszko I, Eichner S, Sasse F, Collisi W, Poso A, Schax E, Walter JG, Scheper T, Kock K, Herrmann C, Aliuos P, Reuter G, Zeilinger C, Kirschning A. New, Non-Quinone Fluorogeldanamycin Derivatives Strongly Inhibit Hsp90. Chembiochem. 2015;16(2):302-11.

2014

Seras-Franzoso J, Peebo K, Garcia-Fruitos E, Vazquez E, Rinas U, Villaverde A. Improving Protein Delivery of Fibroblast Growth Factor-2 from Bacterial Inclusion Bodies Used as Cell Culture Substrates. Acta Biomater. 2014;10(3):1354-9.

Ricke-Hoch M, Bultmann I, Stapel B, Condorelli G, Rinas U, Sliwa K, Scherr M, Hilfiker-Kleiner D. Opposing Roles of Akt and Stat3 in the Protection of the Maternal Heart from Peripartum Stress. Cardiovasc Res. 2014;101(4):587-96. Epub 2014/01/23.

Li Z, Nimtz M, Rinas U. The Metabolic Potential of Escherichia Coli Bl21 in Defined and Rich Medium. Microb Cell Fact. 2014;13(1):45.

Li Z, Carstensen B, Rinas U. Smart Sustainable Bottle (Ssb) System for E. Coli Based Recombinant Protein Production. Microb Cell Fact. 2014;13:153.

Hartwig S, Frister T, Alemdar S, Li Z, Krings U, Berger RG, Scheper T, Beutel S. Expression, Purification and Activity Assay of a Patchoulol Synthase Cdna Variant Fused to Thioredoxin in Escherichia Coli. Protein Expr Purif. 2014;97:61-71.

2013

Wolff C, Beutel S, Scheper T. Tubular Membrane Bioreactors for Biotechnological Processes. Appl Microbiol Biotechnol. 2013;97(3):929-37.

Vallejo LF, Rinas U. Folding and Dimerization Kinetics of Bone Morphogenetic Protein-2, a Member of the Transforming Growth Factor-Beta Family. FEBS J. 2013;280(1):83-92.

Seras-Franzoso J, Peebo K, Luis Corchero J, Tsimbouri PM, Unzueta U, Rinas U, Dalby MJ, Vazquez E, Garcia-Fruitos E, Villaverde A. A Nanostructured Bacterial Bioscaffold for the Sustained Bottom-up Delivery of Protein Drugs. Nanomedicine (Lond). 2013;8(10):1587-99.

Sandor M, Rudinger F, Bienert R, Grimm C, Solle D, Scheper T. Comparative Study of Non-Invasive Monitoring Via Infrared Spectroscopy for Mammalian Cell Cultivations. J Biotechnol. 2013;168(4):636-45.

Mönster A, Villain L, Scheper T, Beutel S. One-Step-Purification of Penicillin G Amidase from Cell Lysate Using Ion-Exchange Membrane Adsorbers. Journal of Membrane Science. 2013;444:359-64.

Meyer M, Scheper T, Walter JG. Aptamers: Versatile Probes for Flow Cytometry. Appl Microbiol Biotechnol. 2013;97(16):7097-109.

Lavrentieva A, Hatlapatka T, Neumann A, Weyand B, Kasper C. Potential for Osteogenic and Chondrogenic Differentiation of Msc. Adv Biochem Eng Biotechnol. 2013;129:73-88.

Kaleta C, Schauble S, Rinas U, Schuster S. Metabolic Costs of Amino Acid and Protein Production in Escherichia Coli. Biotechnol J. 2013;8(9):1105-14.

Jonczyk P, Takenberg M, Hartwig S, Beutel S, Berger RG, Scheper T. Cultivation of Shear Stress Sensitive Microorganisms in Disposable Bag Reactor Systems. J Biotechnol. 2013;167(4):370-6.

Cano-Garrido O, Rodriguez-Carmona E, Diez-Gil C, Vazquez E, Elizondo E, Cubarsi R, Seras-Franzoso J, Corchero JL, Rinas U, Ratera I, Ventosa N, Veciana J, Villaverde A, Garcia-Fruitos E. Supramolecular Organization of Protein-Releasing Functional Amyloids Solved in Bacterial Inclusion Bodies. Acta Biomater. 2013;9(4):6134-42.

Bice I, Celik H, Wolff C, Beutel S, Zahid M, Hitzmann B, Rinas U, Kasper C, Gerardy-Schahn R, Scheper T. Downstream Processing of High Chain Length Polysialic Acid Using Membrane Adsorbers and Clay Minerals for Application in Tissue Engineering. Engineering in Life Sciences. 2013;13(2):140-8.

2012

Walter J-G, Stahl F, Scheper T. Aptamers as Affinity Ligands for Downstream Processing. Engineering in Life Sciences. 2012;12(5):496-506.

Vazquez E, Corchero JL, Burgueno JF, Seras-Franzoso J, Kosoy A, Bosser R, Mendoza R, Martinez-Lainez JM, Rinas U, Fernandez E, Ruiz-Avila L, Garcia-Fruitos E, Villaverde A. Functional Inclusion Bodies Produced in Bacteria as Naturally Occurring Nanopills for Advanced Cell Therapies. Adv Mater. 2012;24(13):1742-7.

Stahl F, Hitzmann B, Mutz K, Landgrebe D, Lubbecke M, Kasper C, Walter J, Scheper T. Transcriptome Analysis. Adv Biochem Eng Biotechnol. 2012;127:1-25.

Sinitsyna ES, Walter JG, Vlakh EG, Stahl F, Kasper C, Tennikova TB. Macroporous Methacrylate-Based Monoliths as Platforms for DNA Microarrays. Talanta. 2012;93:139-46. Epub 2012/04/10.

Olmer R, Lange A, Selzer S, Kasper C, Haverich A, Martin U, Zweigerdt R. Suspension Culture of Human Pluripotent Stem Cells in Controlled, Stirred Bioreactors. Tissue Eng Part C Methods. 2012;18(10):772-84.

Lübbecke M, Walter J-G, Stahl F, Scheper T. Aptamers as Detection Molecules on Reverse Phase Protein Microarrays for the Analysis of Cell Lysates. Engineering in Life Sciences. 2012;12(2):144-51.

Kress S, Neumann A, Weyand B, Kasper C. Stem Cell Differentiation Depending on Different Surfaces. Adv Biochem Eng Biotechnol. 2012;126:263-83.

Kasper C, Alborzinia H, Can S, Kitanovic I, Meyer A, Geldmacher Y, Oleszak M, Ott I, Wolfl S, Sheldrick WS. Synthesis and Cellular Impact of Diene-Ruthenium(Ii) Complexes: A New Class of Organoruthenium Anticancer Agents. J Inorg Biochem. 2012;106(1):126-33.

Chen R, John J, Lavrentieva A, Müller S, Tomala M, Zhao Y, Zweigerdt R, Beutel S, Hitzmann B, Kasper C, Martin U, Rinas U, Stahl F, Scheper T. Cytokine Production Using Membrane Adsorbers: Human Basic Fibroblast Growth Factor Produced by Escherichia Coli. Engineering in Life Sciences. 2012;12(1):29-38.

Behr L, Joeris K, Burnett M, Scheper T. A Novel in Situ Probe for Oxygen Uptake Rate Measurement in Mammalian Cell Cultures. Biotechnol Prog. 2012;28(2):581-6.

2011

Zhu G, Lübbecke M, Walter JG, Stahl F, Scheper T. Characterization of Optimal Aptamer-Microarray Binding Chemistry and Spacer Design. Chemical Engineering & Technology. 2011;34(12):2022-8.

Wendt H, Hillmer A, Reimers K, Kuhbier JW, Schafer-Nolte F, Allmeling C, Kasper C, Vogt PM. Artificial Skin--Culturing of Different Skin Cell Lines for Generating an Artificial Skin Substitute on Cross-Weaved Spider Silk Fibres. PLoS One. 2011;6(7):e21833.

Ralla K, Sohling U, Suck K, Sander F, Kasper C, Ruf F, Scheper T. Adsorption and Separation of Proteins by a Synthetic Hydrotalcite. Colloids Surf B Biointerfaces. 2011;87(2):217-25.

Platas Barradas O, Jandt U, Hass R, Kasper C, Sandig V, Portner R, Zeng AP. Physical Methods for Synchronization of a Human Production Cell Line. BMC Proc. 2011;5 Suppl 8:P49.

Perez J, Lucena E, Hughes M, Lizcano L, Kasper CK. Preimplantation Genetic Diagnosis--a Historical Annotation: First Pgd Baby Turns Fifteen. Haemophilia. 2011;17 Suppl 1:18-9.

Majore I, Moretti P, Stahl F, Hass R, Kasper C. Growth and Differentiation Properties of Mesenchymal Stromal Cell Populations Derived from Whole Human Umbilical Cord. Stem Cell Rev. 2011;7(1):17-31.

Lavrentieva A, Hatlapatka T, Winkler R, Hass R, Kasper C. Strategies in Umbilical Cord-Derived Mesenchymal Stem Cells Expansion: Influence of Oxygen, Culture Medium and Cell Separation. BMC Proc. 2011;5 Suppl 8:P88.

Landgrebe D, Kasper C, Scheper T. Increasing Productivity of Hybridoma Cell Lines by Sorting by Side Scattering Light. BMC Proc. 2011;5 Suppl 8:P83.

Kuhbier JW, Reimers K, Kasper C, Allmeling C, Hillmer A, Menger B, Vogt PM, Radtke C. First Investigation of Spider Silk as a Braided Microsurgical Suture. J Biomed Mater Res B Appl Biomater. 2011;97(2):381-7. Epub 2011/03/25.

Korzhikov VA, Vlakh EG, Kasper K, Tennikova TB. [in Vitro Modeling of Cell-Scaffold Interaction]. Bioorg Khim. 2011;37(3):302-9.

Kokpinar O, Walter JG, Shoham Y, Stahl F, Scheper T. Aptamer-Based Downstream Processing of His-Tagged Proteins Utilizing Magnetic Beads. Biotechnol Bioeng. 2011;108(10):2371-9.

Hilfiker A, Kasper C, Hass R, Haverich A. Mesenchymal Stem Cells and Progenitor Cells in Connective Tissue Engineering and Regenerative Medicine: Is There a Future for Transplantation? Langenbecks Arch Surg. 2011;396(4):489-97. Epub 2011/03/05.

Christel A, Williams S, Kasper C, Hoffmann A, Behrens P. Nanoparticles for multiple functionalization of scaffolds for stem cell engineering. Tissue Engineering Part A. 2011;17(3-4):564-5.

Hatlapatka T, Moretti P, Lavrentieva A, Hass R, Marquardt N, Jacobs R, Kasper C. Optimization of Culture Conditions for the Expansion of Umbilical Cord-Derived Mesenchymal Stem or Stromal Cell-Like Cells Using Xeno-Free Culture Conditions. Tissue Eng Part C Methods. 2011;17(4):485-93. Epub 2010/12/21.

Hass R, Kasper C, Bohm S, Jacobs R. Different Populations and Sources of Human Mesenchymal Stem Cells (Msc): A Comparison of Adult and Neonatal Tissue-Derived Msc. Cell Commun Signal. 2011;9:12.

Haake C, Bonk S, Parsiegla J, Tomala M, Loya K, Sgodda M, Cantz T, Schambach A, Kasper C, Scheper T. Comparison of the Activity and Pluripotency Maintaining Potential of Human Leukemia Inhibitory Factor (Lif) Produced in E.Coli and Cho Cells. BMC Proc. 2011;5 Suppl 8:P109.

Chen R, John J, Rode B, Hitzmann B, Gerardy-Schahn R, Kasper C, Scheper T. Comparison of Polysialic Acid Production in Escherichia Coli K1 During Batch Cultivation and Fed-Batch Cultivation Applying Two Different Control Strategies. J Biotechnol. 2011;154(4):222-9.

Boehm S, Lupu Y, Machluf M, Kasper C. Osteogenic Differentiation of Adipose Mesenchymal Stem Cells with Bmp-2 Embedded Microspheres in a Rotating Bed Bioreactor. BMC Proc. 2011;5 Suppl 8:P74.

Bals C, Schambach A, Meyer J, Scheper T, Rinas U. Expression and Purification of Bioactive Soluble Murine Stem Cell Factor from Recombinant Escherichia Coli Using Thioredoxin as Fusion Partner. J Biotechnol. 2011;152(1-2):1-8.

Akin M, Prediger A, Yuksel M, Hopfner T, Demirkol DO, Beutel S, Timur S, Scheper T. A New Set up for Multi-Analyte Sensing: At-Line Bio-Process Monitoring. Biosens Bioelectron. 2011;26(11):4532-7.

Abdulkerim E, Baganz S, Schambach A, Kasper C, Scheper T. Production and Purification of Tgfb-1 in Cho-Cells. BMC Proc. 2011;5 Suppl 8:P134.

2010

Tomala M, Lavrentieva A, Moretti P, Rinas U, Kasper C, Stahl F, Schambach A, Warlich E, Martin U, Cantz T, Scheper T. Preparation of Bioactive Soluble Human Leukemia Inhibitory Factor from Recombinant Escherichia Coli Using Thioredoxin as Fusion Partner. Protein Expr Purif. 2010;73(1):51-7.

Suck K, Roeker S, Diederichs S, Anton F, Sanz-Herrera JA, Ochoa I, Doblare M, Scheper T, van Griensven M, Kasper C. A Rotating Bed System Bioreactor Enables Cultivation of Primary Osteoblasts on Well-Characterized Sponceram Regarding Structural and Flow Properties. Biotechnol Prog. 2010;26(3):671-8.

Moretti P, Hatlapatka T, Marten D, Lavrentieva A, Majore I, Hass R, Kasper C. Mesenchymal Stromal Cells Derived from Human Umbilical Cord Tissues: Primitive Cells with Potential for Clinical and Tissue Engineering Applications. Adv Biochem Eng Biotechnol. 2010;123:29-54.

Kuhbier JW, Weyand B, Radtke C, Vogt PM, Kasper C, Reimers K. Isolation, Characterization, Differentiation, and Application of Adipose-Derived Stem Cells. Adv Biochem Eng Biotechnol. 2010;123:55-105.

Hatlapatka T, Lavrentieva A, Moretti P, Hass R, Marquardt N, Jacobs R, Kasper C. Shaping the Microenvironment of Umbilical Cord-Derived Mesenchymal Stem Cell-Like Cells. J Stem Cells Regen Med. 2010;6(2):101-2.

2009

van Griensven M, Diederichs S, Roeker S, Boehm S, Peterbauer A, Wolbank S, Riechers D, Stahl F, Kasper C. Mechanical Strain Using 2d and 3d Bioreactors Induces Osteogenesis: Implications for Bone Tissue Engineering. Adv Biochem Eng Biotechnol. 2009;112:95-123. Epub 2009/03/18.

Roeker S, Bohm S, Diederichs S, Bode F, Quade A, Korzhikov V, van Griensven M, Tennikova TB, Kasper C. A Study on the Influence of Biocompatible Composites with Bioactive Ligands toward Their Effect on Cell Adhesion and Growth for the Application in Bone Tissue Engineering. J Biomed Mater Res B Appl Biomater. 2009;91(1):153-62. Epub 2009/04/30.

Rober M, Walter J, Vlakh E, Stahl F, Kasper C, Tennikova T. New 3-D Microarray Platform Based on Macroporous Polymer Monoliths. Anal Chim Acta. 2009;644(1-2):95-103.

Ralla K, Anton F, Scheper T, Kasper C. Application of Conjoint Liquid Chromatography with Monolithic Disks for the Simultaneous Determination of Immunoglobulin G and Other Proteins Present in a Cell Culture Medium. J Chromatogr A. 2009;1216(13):2671-5.

Majore I, Moretti P, Hass R, Kasper C. Identification of Subpopulations in Mesenchymal Stem Cell-Like Cultures from Human Umbilical Cord. Cell Commun Signal. 2009;7:6.

Diederichs S, Roker S, Marten D, Peterbauer A, Scheper T, van Griensven M, Kasper C. Dynamic Cultivation of Human Mesenchymal Stem Cells in a Rotating Bed Bioreactor System Based on the Z Rp Platform. Biotechnol Prog. 2009;25(6):1762-71.

2008

Stark Y, Bruns S, Stahl F, Kasper C, Wesemann M, Grothe C, Scheper T. A Study on Polysialic Acid as a Biomaterial for Cell Culture Applications. J Biomed Mater Res A. 2008;85(1):1-13.

Rode B, Endres C, Ran C, Stahl F, Beutel S, Kasper C, Galuska S, Geyer R, Muhlenhoff M, Gerardy-Schahn R, Scheper T. Large-Scale Production and Homogenous Purification of Long Chain Polysialic Acids from E. Coli K1. J Biotechnol. 2008;135(2):202-9.

Korzhikov V, Roeker S, Vlakh E, Kasper C, Tennikova T. Synthesis of Multifunctional Polyvinylsaccharide Containing Controllable Amounts of Biospecific Ligands. Bioconjug Chem. 2008;19(3):617-25.

2007

Suck K, Behr L, Fischer M, Hoffmeister H, van Griensven M, Stahl F, Scheper T, Kasper C. Cultivation of Mc3t3-E1 Cells on a Newly Developed Material (Sponceram) Using a Rotating Bed System Bioreactor. J Biomed Mater Res A. 2007;80(2):268-75.

Bruns S, Stark Y, Wieland M, Stahl F, Kasper C, Scheper T. Fast and Efficient Screening System for New Biomaterials in Tissue Engineering: A Model for Peripheral Nerve Regeneration. J Biomed Mater Res A. 2007;81(3):736-47.

Publications in 2014 and 2015 acknowledging usage of growth factors produced by this unit without co-authorship from members of this unit.

Schwanke K, Merkert S, Kempf H, Hartung S, Jara-Avaca M, Templin C, Gohring G, Haverich A, Martin U, Zweigerdt R. Fast and Efficient Multitransgenic Modification of Human Pluripotent Stem Cells. Hum Gene Ther Methods. 2014;25(2):136-53.

Merkert S, Wunderlich S, Bednarski C, Beier J, Haase A, Dreyer AK, Schwanke K, Meyer J, Gohring G, Cathomen T, Martin U. Efficient Designer Nuclease-Based Homologous Recombination Enables Direct Pcr Screening for Footprintless Targeted Human Pluripotent Stem Cells. Stem Cell Reports. 2014;2(1):107-18.

Konze SA, van Diepen L, Schroder A, Olmer R, Moller H, Pich A, Weissmann R, Kuss AW, Zweigerdt R, Buettner FF. Cleavage of E-Cadherin and Beta-Catenin by Calpain Affects Wnt Signaling and Spheroid Formation in Suspension Cultures of Human Pluripotent Stem Cells. Mol Cell Proteomics. 2014;13(4):990-1007. Epub 2014/02/01.

Kempf H, Olmer R, Kropp C, Ruckert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Stem Cell Reports. 2014;3(6):1132-46.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

The growth factor provided by this REBIRTH Unit is acknowledged in several publications of other REBIRTH Units, e.g. 1.1., 1.2, 1.3, 1.4, 4.2, 6.2, 7.1, 10.2, without co-authorship of Unit 10.1.

Unit 10.2 - Mass Production of Pluripotent Stem Cells and Derivatives

2016

Weber N, Schwanke K, Greten S, Wendland M, Iorga B, Fischer M, Geers-Knorr C, Hegermann J, Wrede C, Fiedler J, Kempf H, Franke A, Piep B, Pfanne A, Thum T, Martin U, Brenner B, Zweigerdt R, Kraft T. Stiff matrix induces switch to pure beta-cardiac myosin heavy chain expression in human ESC-derived cardiomyocytes. Basic research in cardiology. 2016;111(6):68.

Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, Dittrich M, Maetzig T, Zimmer K, Remke J, Just A, Fendrich J, Scherf K, Bolesani E, Schambach A, Weidemann F, Zweigerdt R, de Windt LJ, Engelhardt S, Dandekar T, Batkai S, Thum T. Long noncoding RNA Chast promotes cardiac remodeling. Science translational medicine. 2016;8(326):326ra22.

Kropp C, Kempf H, Halloin C, Robles-Diaz D, Franke A, Scheper T, Kinast K, Knorpp T, Joos TO, Haverich A, Martin U, Zweigerdt R, Olmer R. Impact of Feeding Strategies on the Scalable Expansion of Human Pluripotent Stem Cells in Single-Use Stirred Tank Bioreactors. Stem cells translational medicine. 2016;5(10):1289-301.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature communications. 2016;7:13602.

Kempf H, Andree B, Zweigerdt R. Large-scale production of human pluripotent stem cell derived cardiomyocytes. Adv Drug Deliv Rev. 2016;96:18-30.

Andree B, Zweigerdt R. Directing Cardiomyogenic Differentiation and Transdifferentiation By Ectopic Gene Expression - Direct Transition Or Reprogramming Detour? Curr Gene Ther. 2016;16(1):14-20.

2015

Kempf H, Kropp C, Olmer R, Martin U, Zweigerdt R. Cardiac Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Nat Protoc. 2015;10(9):1345-61.

Bergstrom G, Christoffersson J, Schwanke K, Zweigerdt R, Mandenius CF. Stem Cell Derived in Vivo-Like Human Cardiac Bodies in a Microfluidic Device for Toxicity Testing by Beating Frequency Imaging. Lab Chip. 2015;15(15):3242-9.

Rojas SV, Martens A, Zweigerdt R, Baraki H, Rathert C, Schecker N, Rojas-Hernandez S, Schwanke K, Martin U, Haverich A, Kutschka I. Transplantation Effectiveness of Induced Pluripotent Stem Cells Is Improved by a Fibrinogen Biomatrix in an Experimental Model of Ischemic Heart Failure. Tissue Eng Part A. 2015;21(13-14):1991-2000. Epub 2015/04/14.

2014

Antonopoulos GC, Pscheniza D, Lorbeer1 R-A, Heidrich M, Schwanke K, Zweigerdt, Ripken T, Meyer H. Correction of image artifacts caused by refractive cylindrical surfaces in scanning optical tomography. Biomedizinische Technik 09/2014; 59(s1). DOI: 10.1515/bmt-2014-4219

Zweigerdt R, Gruh I, Martin U. Your Heart on a Chip: Ipsc-Based Modeling of Barth-Syndrome-Associated Cardiomyopathy. Cell Stem Cell. 2014;15(1):9-11.

Schwanke K, Merkert S, Kempf H, Hartung S, Jara-Avaca M, Templin C, Gohring G, Haverich A, Martin U, Zweigerdt R. Fast and Efficient Multitransgenic Modification of Human Pluripotent Stem Cells. Hum Gene Ther Methods. 2014;25(2):136-53.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Zweigerdt R, Schwanke K, Rojas-Hernandez S, Martin U, Saito S, Schmitto JD, Haverich A, Kutschka I. Substantial Early Loss of Induced Pluripotent Stem Cells Following Transplantation in Myocardial Infarction. Artif Organs. 2014;38(11):978-84.

Martens A, Rojas SV, Baraki H, Rathert C, Schecker N, Hernandez SR, Schwanke K, Zweigerdt R, Martin U, Saito S, Haverich A, Kutschka I. Macroscopic Fluorescence Imaging: A Novel Technique to Monitor Retention and Distribution of Injected Microspheres in an Experimental Model of Ischemic Heart Failure. PLoS One. 2014;9(8):e101775.

Konze SA, van Diepen L, Schroder A, Olmer R, Moller H, Pich A, Weissmann R, Kuss AW, Zweigerdt R, Buettner FF. Cleavage of E-Cadherin and Beta-Catenin by Calpain Affects Wnt Signaling and Spheroid Formation in Suspension Cultures of Human Pluripotent Stem Cells. Mol Cell Proteomics. 2014;13(4):990-1007.

Kempf H, Olmer R, Kropp C, Ruckert M, Jara-Avaca M, Robles-Diaz D, Franke A, Elliott DA, Wojciechowski D, Fischer M, Roa Lara A, Kensah G, Gruh I, Haverich A, Martin U, Zweigerdt R. Controlling Expansion and Cardiomyogenic Differentiation of Human Pluripotent Stem Cells in Scalable Suspension Culture. Stem Cell Reports. 2014;3(6):1132-46.

Andree B, Bela K, Horvath T, Lux M, Ramm R, Venturini L, Ciubotaru A, Zweigerdt R, Haverich A, Hilfiker A. Successful Re-Endothelialization of a Perfusable Biological Vascularized Matrix (Biovam) for the Generation of 3d Artificial Cardiac Tissue. Basic Res Cardiol. 2014;109(6):441.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

2013

Kensah G, Roa Lara A, Dahlmann J, Zweigerdt R, Schwanke K, Hegermann J, Skvorc D, Gawol A, Azizian A, Wagner S, Maier LS, Krause A, Drager G, Ochs M, Haverich A, Gruh I, Martin U. Murine and Human Pluripotent Stem Cell-Derived Cardiac Bodies Form Contractile Myocardial Tissue in Vitro. Eur Heart J. 2013;34(15):1134-46.

Hartung S, Schwanke K, Haase A, David R, Franz WM, Martin U, Zweigerdt R. Directing Cardiomyogenic Differentiation of Human Pluripotent Stem Cells by Plasmid-Based Transient Overexpression of Cardiac Transcription Factors. Stem Cells Dev. 2013;22(7):1112-25.

Dahlmann J, Kensah G, Kempf H, Skvorc D, Gawol A, Elliott DA, Drager G, Zweigerdt R, Martin U, Gruh I. The Use of Agarose Microwells for Scalable Embryoid Body Formation and Cardiac Differentiation of Human and Murine Pluripotent Stem Cells. Biomaterials. 2013;34(10):2463-71.

2012

Templin C, Zweigerdt R, Schwanke K, Olmer R, Ghadri JR, Emmert MY, Muller E, Kuest SM, Cohrs S, Schibli R, Kronen P, Hilbe M, Reinisch A, Strunk D, Haverich A, Hoerstrup S, Luscher TF, Kaufmann PA, Landmesser U, Martin U. Transplantation and Tracking of Human-Induced Pluripotent Stem Cells in a Pig Model of Myocardial Infarction: Assessment of Cell Survival, Engraftment, and Distribution by Hybrid Single Photon Emission Computed Tomography/Computed Tomography of Sodium Iodide Symporter Transgene Expression. Circulation. 2012;126(4):430-9.

Olmer R, Lange A, Selzer S, Kasper C, Haverich A, Martin U, Zweigerdt R. Suspension Culture of Human Pluripotent Stem Cells in Controlled, Stirred Bioreactors. Tissue Eng Part C Methods. 2012;18(10):772-84.

Chen R, John J, Lavrentieva A, Müller S, Tomala M, Zhao Y, Zweigerdt R, Beutel S, Hitzmann B, Kasper C, Martin U, Rinas U, Stahl F, Scheper T. Cytokine Production Using Membrane Adsorbers: Human Basic Fibroblast Growth Factor Produced by Escherichia Coli. Engineering in Life Sciences. 2012;12(1):29-38.

2011

Zweigerdt R, Olmer R, Singh H, Haverich A, Martin U. Scalable Expansion of Human Pluripotent Stem Cells in Suspension Culture. Nat Protoc. 2011;6(5):689-700.

Palecek J, Zweigerdt R, Olmer R, Martin U, Kirschning A, Drager G. A Practical Synthesis of Rho-Kinase Inhibitor Y-27632 and Fluoro Derivatives and Their Evaluation in Human Pluripotent Stem Cells. Org Biomol Chem. 2011;9(15):5503-10.

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I. Induced Pluripotent Stem Cell (Ipsc)-Derived Flk-1 Progenitor Cells Engraft, Differentiate, and Improve Heart Function in a Mouse Model of Acute Myocardial Infarction. Eur Heart J. 2011;32(21):2634-41.

Kempf H, Lecina M, Ting S, Zweigerdt R, Oh S. Distinct Regulation of Mitogen-Activated Protein Kinase Activities Is Coupled with Enhanced Cardiac Differentiation of Human Embryonic Stem Cells. Stem Cell Res. 2011;7(3):198-209.

Unit 10.3 - Biostabilization of Tissues and Macromolecular Assamblies

2017

Lauterboeck L, Wolkers WF, Glasmacher B. Cryobiological parameters of multipotent stromal cells obtained from different sources. Cryobiology. 2017;74:93-102.

2016

Zhang M, Oldenhof H, Sieme H, Wolkers WF. Combining endocytic and freezing-induced trehalose uptake for cryopreservation of mammalian cells. Biotechnol Prog. 2016.

Zhang M, Oldenhof H, Sieme H, Wolkers WF. Freezing-induced uptake of trehalose into mammalian cells facilitates cryopreservation. Bba-Biomembranes. 2016;1858(6):1400-9.

Sydykov B, Oldenhof H, Sieme H, Wolkers WF. Hydrogen Bonding Interactions and Enthalpy Relaxation in Sugar/Protein Glasses. J Pharm Sci. 2016.

Oldenhof H, Schutze S, Wolkers WF, Sieme H. Fourier transform infrared spectroscopic analysis of sperm chromatin structure and DNA stability. Andrology. 2016;4(3):430-41.

2015

Repanas A, Wolkers WF, Gryshkov O, Müller M, Glasmacher B. Pcl/Peg Electrospun fibers as drug carriers for the controlled delivery of dipyridamole. Journal of In Silico & In Vitro Pharmacology 1, 1:2, 10p. 2015.

Wang S. Characterization of diffusion processes for preservation of biological heart valve scaffolds. , PhD dissertation. Defense 15 Jan 2015.

Oldenhof H, Heutelbeck A, Blasse AK, Bollwein H, Martinsson G, Wolkers WF, Sieme H. Tolerance of Spermatozoa to Hypotonic Stress: Role of Membrane Fluidity and Correlation with Cryosurvival. Reprod Fertil Dev. 2015;27(2):285-93.

Sassi P, Caponi S, Ricci M, Morresi A, Oldenhof H, Wolkers WF, Fioretto D. Infrared Versus Light Scattering Techniques to Monitor the Gel to Liquid Crystal Phase Transition in Lipid Membranes. Journal of Raman Spectroscopy. 2015;46(7):644-51.

Sieme H, Oldenhof H, Wolkers WF. Sperm Membrane Behaviour During Cooling and Cryopreservation. Reprod Domest Anim. 2015;50 Suppl 3:20-6.

Wang S, Oldenhof H, Goecke T, Ramm R, Harder M, Haverich A, Hilfiker A, Wolkers WF. Sucrose Diffusion in Decellularized Heart Valves for Freeze-Drying. Tissue Eng Part C Methods. 2015;21(9):922-31.

Wolkers WF, Hilfiker A. Freeze-Drying of Decellularized Heart Valve Tissues. Methods Mol Biol. 2015;1257:499-506.

Wolkers WF, Oldenhof H. Use of in Situ Fourier Transform Infrared Spectroscopy to Study Freezing and Drying of Cells. Methods Mol Biol. 2015;1257:147-61.

Wolkers WF, Oldenhof H. Biomolecular fingerprinting in the dried state. Biomedical Spectroscopy and Imaging. 2015; 4: 331-340.

Repanas A, Wolkers WF, Gryshkov O, Kalozoumis P, Mueller M, Zernetsch H, Korossis S, Glasmacher B. Coaxial electrospinning as a process to engineer biodegradable polymeric scaffolds as a drug delivery systems for anti-inflammatory and anti-thrombotic pharmaceutical agents. Clinical & Experimental Pharmacology. 2015; 5:5, 8p.

2014

Qin Z, Balasubramanian SK, Wolkers WF, Pearce JA, Bischof JC. Correlated Parameter Fit of Arrhenius Model for Thermal Denaturation of Proteins and Cells. Ann Biomed Eng. 2014;42(12):2392-404.

Wang S, Oldenhof H, Dai X, Haverich A, Hilfiker A, Harder M, Wolkers WF. Protein Stability in Stored Decellularized Heart Valve Scaffolds and Diffusion Kinetics of Protective Molecules. Biochim Biophys Acta. 2014;1844(2):430-8.

2013

Oldenhof H, Gojowsky M, Wang S, Henke S, Yu C, Rohn K, Wolkers WF, Sieme H. Osmotic Stress and Membrane Phase Changes During Freezing of Stallion Sperm: Mode of Action of Cryoprotective Agents. Biol Reprod. 2013;88(3):68.

Schmid S, Henning H, Oldenhof H, Wolkers WF, Petrunkina AM, Waberski D. The Specific Response to Capacitating Stimuli Is a Sensitive Indicator of Chilling Injury in Hypothermically Stored Boar Spermatozoa. Andrology. 2013;1(3):376-86.

Oldenhof H, Akhoondi M, Sieme H, Wolkers WF. Use of Fourier transform infrared spectroscopy to determine optimal cooling rates for cryopreservation of cells. Biomedical Spectroscopy and Imaging. 2013;2(2):83-90.

Akhoondi, M. PhD dissertation: Modeling of water transport processes during freezing of mammalian cells. 15 Jan 2013.

2012

Akhoondi M, Oldenhof H, Sieme H, Wolkers WF. Freezing-Induced Cellular and Membrane Dehydration in the Presence of Cryoprotective Agents. Mol Membr Biol. 2012;29(6):197-206.

Blasse AK, Oldenhof H, Ekhlasi-Hundrieser M, Wolkers WF, Sieme H, Bollwein H. Osmotic Tolerance and Intracellular Ion Concentrations of Bovine Sperm Are Affected by Cryopreservation. Theriogenology. 2012;78(6):1312-20.

Glafke C, Akhoondi M, Oldenhof H, Sieme H, Wolkers WF. Cryopreservation of Platelets Using Trehalose: The Role of Membrane Phase Behavior During Freezing. Biotechnol Prog. 2012;28(5):1347-54.

Oldenhof H, Friedel K, Akhoondi M, Gojowsky M, Wolkers WF, Sieme H. Membrane Phase Behavior During Cooling of Stallion Sperm and Its Correlation with Freezability. Mol Membr Biol. 2012;29(3-4):95-106.

Sanchez V, Redmann K, Wistuba J, Wubbeling F, Burger M, Oldenhof H, Wolkers WF, Kliesch S, Schlatt S, Mallidis C. Oxidative DNA Damage in Human Sperm Can Be Detected by Raman Microspectroscopy. Fertil Steril. 2012;98(5):1124-9 e1-3.

Stoll C, Holovati JL, Acker JP, Wolkers WF. Synergistic Effects of Liposomes, Trehalose, and Hydroxyethyl Starch for Cryopreservation of Human Erythrocytes. Biotechnol Prog. 2012;28(2):364-71.

Wang S, Goecke T, Meixner C, Haverich A, Hilfiker A, Wolkers WF. Freeze-Dried Heart Valve Scaffolds. Tissue Eng Part C Methods. 2012;18(7):517-25.

Wang S, Oldenhof H, Hilfiker A, Harder M, Wolkers WF. Solvent accesibility of proteins in heart valve scaffolds. Biomedical Spectroscopy and Imaging 1 2012:79-87.

2011

Akhoondi M, Oldenhof H, Stoll C, Sieme H, Wolkers WF. Membrane Hydraulic Permeability Changes During Cooling of Mammalian Cells. Biochim Biophys Acta. 2011;1808(3):642-8.

Diekmann U, Spindler R, Wolkers WF, Glasmacher B, Muller T. Cryopreservation and Quality Control of Mouse Embryonic Feeder Cells. Cryobiology. 2011;63(2):104-10.

Oldenhof H, Blasse AK, Wolkers WF, Bollwein H, Sieme H. Osmotic Properties of Stallion Sperm Subpopulations Determined by Simultaneous Assessment of Cell Volume and Viability. Theriogenology. 2011;76(2):386-91.

Ropke T, Oldenhof H, Leiding C, Sieme H, Bollwein H, Wolkers WF. Liposomes for Cryopreservation of Bovine Sperm. Theriogenology. 2011;76(8):1465-72.

Spindler R, Wolkers WF, Glasmacher B. Dimethyl Sulfoxide and Ethylene Glycol Promote Membrane Phase Change During Cryopreservation. Cryo Letters. 2011;32(2):148-57.

Stadnick H, Stoll C, Wolkers WF, Acker JP, Holovati JL. The Effect of Liposome Treatment on the Quality of Hypothermically Stored Red Blood Cells. Biopreserv Biobank. 2011;9(4):335-42.

Stoll C, Holovati JL, Acker JP, Wolkers WF. Liposomes Composed of Unsaturated Lipids for Membrane Modification of Human Erythrocytes. Mol Membr Biol. 2011;28(7-8):454-61.

Stoll C, Stadnick H, Kollas O, Holovati JL, Glasmacher B, Acker JP, Wolkers WF. Liposomes Alter Thermal Phase Behavior and Composition of Red Blood Cell Membranes. Biochim Biophys Acta. 2011;1808(1):474-81.

Stoll C, Wolkers WF. Membrane Stability During Biopreservation of Blood Cells. Transfus Med Hemother. 2011;38(2):89-97.

2010

Venkatasubramanian RT, Wolkers WF, Shenoi MM, Barocas VH, Lafontaine D, Soule CL, Iaizzo PA, Bischof JC. Freeze-Thaw Induced Biomechanical Changes in Arteries: Role of Collagen Matrix and Smooth Muscle Cells. Ann Biomed Eng. 2010;38(3):694-706.

2009

Balasubramanian SK, Wolkers WF, Bischof JC. Membrane Hydration Correlates to Cellular Biophysics During Freezing in Mammalian Cells. Biochim Biophys Acta. 2009;1788(5):945-53.

Hagiwara M, Choi JH, Devireddy RV, Roberts KP, Wolkers WF, Makhlouf A, Bischof JC. Cellular Biophysics During Freezing of Rat and Mouse Sperm Predicts Post-Thaw Motility. Biol Reprod. 2009;81(4):700-6.

Shah NB, Wolkers WF, Morrissey M, Sun WQ, Bischof JC. Fourier Transform Infrared Spectroscopy Investigation of Native Tissue Matrix Modifications Using a Gamma Irradiation Process. Tissue Eng Part C Methods. 2009;15(1):33-40.

2007

Wolkers WF, Balasubramanian SK, Ongstad EL, Zec HC, Bischof JC. Effects of Freezing on Membranes and Proteins in Lncap Prostate Tumor Cells. Biochim Biophys Acta. 2007;1768(3):728-36.

Books edited:

Wolkers WF, Oldenhof H editors. Cryopreservation and Freeze-Drying Protocols. Book series: Methods in Molecular Biology, Vol 1275, New York, 528 p, ISBN 978-1-4939-2192-8.

Unit 10.4 - Cell Protection Technology

2017

Rahim MI, Weizbauer A, Evertz F, Hoffmann A, Rohde M, Glasmacher B, Windhagen H, Gross G, Seitz JM, Mueller PP. Differential magnesium implant corrosion coat formation and contribution to bone bonding. J Biomed Mater Res A. 2017;105(3):697-709.

Pogozhykh D, Pakhomova Y, Pervushina O, Hofmann N, Glasmacher B, Zhegunov G. Exploring the Possibility of Cryopreservation of Feline and Canine Erythrocytes by Rapid Freezing with Penetrating and Non-Penetrating Cryoprotectants. PloS one. 2017;12(1):e0169689.

Lauterboeck L, Wolkers WF, Glasmacher B. Cryobiological parameters of multipotent stromal cells obtained from different sources. Cryobiology. 2017;74:93-102.

Chatterjee A, Saha D, Niemann H, Gryshkov O, Glasmacher B, Hofmann N. Effects of cryopreservation on the epigenetic profile of cells. Cryobiology. 2017;74:1-7.

Basu P, Repanas A, Chatterjee A, Glasmacher B, NarendraKumar U, Manjubala I. PEO–CMC blend nanofibers fabrication by electrospinning for soft tissue engineering applications. Materials Letters. 2017;195:10-3.

2016

Repanas A, Bader A, Klett A, Ngezahayo A, Glasmacher B. The effect of dipyridamole embedded in a drug delivery system made by electrospun nanofibers on aortic endothelial cells. Journal of Drug Delivery Science and Technology. 2016;35:343-52.

Repanas A, Andriopoulou S, Glasmacher B. The significance of electrospinning as a method to create fibrous scaffolds for biomedical engineering and drug delivery applications. Journal of Drug Delivery Science and Technology. 2016;31:137-46.

Rahim MI, Tavares A, Evertz F, Kieke M, Seitz JM, Eifler R, Weizbauer A, Willbold E, Jurgen Maier H, Glasmacher B, Behrens P, Hauser H, Mueller PP. Phosphate conversion coating reduces the degradation rate and suppresses side effects of metallic magnesium implants in an animal model. Journal of biomedical materials research Part B, Applied biomaterials. 2016.

Lauterboeck L, Saha D, Chatterjee A, Hofmann N, Glasmacher B. Xeno-Free Cryopreservation of Bone Marrow-Derived Multipotent Stromal Cells from Callithrix jacchus. Biopreserv Biobank. 2016;14(6):530-8.

Gryshkov O, Klyui NI, Temchenko VP, Kyselov VS, Chatterjee A, Belyaev AE, Lauterboeck L, Iarmolenko D, Glasmacher B. Porous biomorphic silicon carbide ceramics coated with hydroxyapatite as prospective materials for bone implants. Materials Science and Engineering: C. 2016;68:143-52.

Dencker F, Dreyer L, Müller D, Zernetsch H, Paasche G, Sindelar R, Glasmacher B. A silicone fiber coating as approach for the reduction of fibroblast growth on implant electrodes. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2016:n/a-n/a.

Chatterjee A, Saha D, Glasmacher B, Hofmann N. Chilling without regrets: Deciphering the effects of cryopreservation on the epigenetic properties of frozen cells will benefit the applications of cryo‐technology. EMBO Reports. 2016;17(3):292-5.

2015

Repanas A, Glasmacher B. Dipyridamole embedded in Polycaprolactone fibers prepared by coaxial electrospinning as a novel drug delivery system. Journal of Drug Delivery Science and Technology. 2015;29:132-42.

Lauterboeck L, Hofmann N, Mueller T, Glasmacher B. Active control of the nucleation temperature enhances freezing survival of multipotent mesenchymal stromal cells. Cryobiology. 2015;71(3):384-90.

Hofmann N, Sun H, Chatterjee A, Saha D, Glasmacher B. Thermal Pretreatment Improves Viability of Cryopreserved Human Endothelial Cells. Biopreserv Biobank. 2015;13(5):348-55.

Alexandros Repanas WFWOGPKMMHZSK, Birgit G. Coaxial Electrospinning as a Process to Engineer Biodegradable Polymeric. Clinical & Experimental Pharmacology. 2015;5(5):-.

Repanas A, Wolkers WF, Gryshkov, Kalozoumis P, Mueller M, Zernetsch H, Korossis S, Glasmacher B. Coaxial electrospinning as a process to engineer biodegradable polymeric scaffolds as drug delivery systems for anti-inflammatory and anti-thrombotic pharmaceutical agents. Clin Exp Pharmacol 2015;5(5):192-199.

Repanas A, Wolkers WF, Gryshkov O, Müller M, Glasmacher B. PCL/PEG electrospun fibers as drug carriers for the controlled delivery of dipyridamole. Journal of In Silico & In Vitro Pharmacology 2015, 1(1:2) in press.

Repanas A, Glasmacher B. Dipyridamole embedded in Polycaprolactone fibers prepared by coaxial electrospinning as a novel drug delivery system. J Drug Delivery Sci Tech 2015;29:132-142.

Lauterboeck L, Hofmann N, Mueller T, Glasmacher B. Active Control of the Nucleation Temperature Enhances Freezing Survival of Multipotent Mesenchymal Stromal Cells. Cryobiology. 2015.

Hofmann N, Sun H, Chatterjee A, Saha D, Glasmacher B. Thermal Pretreatment Improves Viability of Cryopreserved Human Endothelial Cells. Biopreserv Biobank. 2015;13(5):348-55.

Gryshkov O, Hofmann N, Lauterboeck L, Pogozhykh D, Mueller T, Glasmacher B. Multipotent Stromal Cells Derived from Common Marmoset Callithrix Jacchus within Alginate 3d Environment: Effect of Cryopreservation Procedures. Cryobiology. 2015;71(1):103-11. Epub 2015/05/20.

2014

Tegtmeier K, Aliuos P, Stieghorst J, Schickedanz M, Golly F, Zernetsch H, Glasmacher B, Doll T. Aligned Carbon Nanotube-Liquid Silicone Rubber Conductors and Electrode Surfaces for Stimulating Medical Implants. physica status solidi (a). 2014;211(6):1439-47.

Stieghorst J, Tegtmeier K, Aliuos P, Zernetsch H, Glasmacher B, Doll T. Self-Bending Hydrogel Actuation for Electrode Shafts in Cochlear Implants. physica status solidi (a). 2014;211(6):1455-61.

Pfeiffer D, Stefanitsch C, Wankhammer K, Muller M, Dreyer L, Krolitzki B, Zernetsch H, Glasmacher B, Lindner C, Lass A, Schwarz M, Muckenauer W, Lang I. Endothelialization of Electrospun Polycaprolactone (Pcl) Small Caliber Vascular Grafts Spun from Different Polymer Blends. J Biomed Mater Res A. 2014;102(12):4500-9.

Gryshkov O, Pogozhykh D, Zernetsch H, Hofmann N, Mueller T, Glasmacher B. Process Engineering of High Voltage Alginate Encapsulation of Mesenchymal Stem Cells. Mater Sci Eng C Mater Biol Appl. 2014;36:77-83.

Gryshkov O, Pogozhykh D, Hofmann N, Pogozhykh O, Mueller T, Glasmacher B. Encapsulating Non-Human Primate Multipotent Stromal Cells in Alginate Via High Voltage for Cell-Based Therapies and Cryopreservation. PLoS One. 2014;9(9):e107911.

Etheridge ML, Xu Y, Rott L, Choi J, Glasmacher B, Bischof JC. Rf Heating of Magnetic Nanoparticles Improves the Thawing of Cryopreserved Biomaterials. TECHNOLOGY. 2014;02(03):229-42.

Duda S, Dreyer L, Behrens P, Wienecke S, Chakradeo T, Glasmacher B, Haastert-Talini K. Outer Electrospun Polycaprolactone Shell Induces Massive Foreign Body Reaction and Impairs Axonal Regeneration through 3d Multichannel Chitosan Nerve Guides. Biomed Res Int. 2014;2014:835269.

2013

Smits L, Hofmann N, Glasmacher B. Antioxidantien Als Strategie Zur Optimierung Der Kryokonservierung Von Stammzellen Fur Das Tissue Engineering. Biomed Tech (Berl). 2013.

Hofmann N, Chatterjee A, Saha D, Müller T, Pogozhykh D, Glasmacher B. 043 Antioxidants as Additional Additives to Cpa May Help to Minimize Epigenetic Modifications Caused by Me2so. Cryobiology. 2013;67(3):410.

Gryshkov O, Pogozhykh D, Hofmann N, Glasmacher B. 37. Cell Encapsulation into Alginate Micro-Capsules Provides Living Cells with a Mild Environment During Cryopreservation. Cryobiology. 2013;66(3):352.

Glasmacher B, Spindler R, Pogozhykh D, Hofmann N. 27. Advances Towards Standardised Freezing Protocols. Cryobiology. 2013;66(3):349-50.

Chakradeo T. PhD dissertation: Strategies for functionalization of electrospun fibers. 2013

Chatterjee A, Hofmann N, Shcherbakova A, Mueller T, Niemann H, von Neuhoff N, Glasmacher B. Investigation of epigenetic changes caused by cryopreservative procedures. SLTB Conference; Oct 06-09, 2013; Hannover. p. 60.

Chatterjee A, Saha D, Mueller T, Dorsch M, Niemann H, Glasmacher B, Hofmann N. Investigation of epigenetic changes caused by cryopreservative procedures. The annual conference of the German Society of Refrigeration and Air Conditioning (DKV); Nov 20-22, 2013; Hannover. p. 11-2.

Gryshkov O, Hofmann N, Glasmacher B. Electropsraying as a promissing technique for cell encapsulation in semi-permeable micro-capsules for immunoisolation. CryoLetters 2013;34(2):186.

Gryshkov O, Lauterboeck L, Hofmann N, Pogozhykh D, Glasmacher B. of encapsulated mesenchymal stem cells under controlled induced nucleation. IIR Workshop – Cryoprocessing of Biopharmaceuticals and Biomaterials; Sep 04-05, 2013, Dresden.

Gryshkov O, Pogozhykh D, Hofmann N, Mueller T, Glasmacher B. Cryopreservation of electro-spraying alginate encapsulated mesenchymal stem cells. The annual conference of the German Society of Refrigeration and Air Conditioning (DKV); Nov 20-22, 2013; Hannover. p. 10-1.

Gryshkov O, Pogozhykh D, Hofmann N, Mueller T, Glasmacher B. Application of high voltage alginate encapsulation of mesenchymal stem cells for long-term storage. SLTB Conference; Oct 06-09, 2013; Hannover. p. 55.

Gryshkov O, Pogozhykh D, Hofmann N, Mueller T, Glasmacher B. Cryopreservation of stem cells inside alginate 3D constructs after high-voltage encapsulation. Cryobiology 2013;67(3):429.

Gryshkov O, Pogozhykh D, Mueller T, Hofmann N, Glasmacher B. Encapsulation of mesenchymal stem cells into alginate 3D constructs helps to overcome challenges during cryopreservation. 3rd International Congress on Controversies in cryopreservation of stem cells, reproductive cells, tissue and organs (CRYO); Mar 21-23, 2013; Berlin.

Gryshkov O, Zernetsch H, Hofmann N, Pogozhykh D, Glasmacher B. Engineering of artificial perfusion membrane for biomedical applications. 1st Russian-German Conference on Biomedical Engineering; Oct 23–26, 2013; Hannover. p. 85.

Hofmann N, Mueller T, Pogozhykh D, Glasmacher B. Antioxidants as additional CPA minimize oxidative damage in primate MSCs after cryopreservation. 3rd International Congress on Controversies in Cryopreservation of Stem Cells, Tissue and Organs (CRYO); Mar 21-23, 2013; Berlin.

Lauterboeck L, Spindler R, Hofmann N, Glasmacher B. Kryokonservierung humaner Zellen und Gewebe mittels kontrollierter Nukleation. The annual conference of the German Society of Refrigeration and Air Conditioning (DKV); Nov 20-22, 2013; Hannover. p. 12.

Lauterboeck L, Spindler R, Hofmann N, Glasmacher B. Cryopreservation of human cells and tissue under controlled nucleation. SLTB Conference; 06-09 Oct, 2013; Hannover. p. 61.

Repanas A, Lauterboeck L, Glasmacher B. Cryopreservation of Electrospun Scaffolds for Tissue Engineering. SLTB Conference; Oct 06-09. 2013; Hannover. p. 62.

Rittinghaus T, Glasmacher B. Concept for cryopreservation of red blood cells with a conveyor belt system. SLTB Conference; Oct 06-09, 2013; Hannover. p. 57.

Saha D, Hofmann N, Mueller T, Niemann H, Glasmacher B. Influence of cryopreservation procedures in mesenchymal stem cells. SLTB Conference; Oct 06-09, 2013; Hannover. p. 70.

2012

Spindler R. PhD dissertation: Einfluss der Nukleationstemperatur und der Konzentration an Frierschutymitteln auf die Kryokonservierung humaner Zellen. 2012

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Sun H, Glasmacher B, Hofmann N. Compatible Solutes Improve Cryopreservation of Human Endothelial Cells. Cryo Letters. 2012;33(6):485-93.

Spindler R, Rosenhahn B, Hofmann N, Glasmacher B. Video Analysis of Osmotic Cell Response During Cryopreservation. Cryobiology. 2012;64(3):250-60.

2011

Spindler R, Wolkers WF, Glasmacher B. Dimethyl Sulfoxide and Ethylene Glycol Promote Membrane Phase Change During Cryopreservation. Cryo Letters. 2011;32(2):148-57.

Spindler R, Rosenhahn B, Glasmacher B. 43. Controlled Nucleation and Reduced Cpa-Concentration During Freezing. Cryobiology. 2011;63(3):318.

Gruene M, Deiwick A, Koch L, Schlie S, Unger C, Hofmann N, Bernemann I, Glasmacher B, Chichkov B. Laser Printing of Stem Cells for Biofabrication of Scaffold-Free Autologous Grafts. Tissue Eng Part C Methods. 2011;17(1):79-87.

Freimark D, Sehl C, Weber C, Hudel K, Czermak P, Hofmann N, Spindler R, Glasmacher B. Systematic Parameter Optimization of a Me(2)So- and Serum-Free Cryopreservation Protocol for Human Mesenchymal Stem Cells. Cryobiology. 2011;63(2):67-75. Epub 2011/05/31.

Ehlers A, Baumann F, Spindler R, Glasmacher B, Rosenhahn B. Pca Enhanced Training Data for Adaboost. In: Real P, Diaz-Pernil D, Molina-Abril H, Berciano A, Kropatsch W, editors. Computer Analysis of Images and Patterns: Springer Berlin Heidelberg; 2011. p. 410-9.

Diekmann U, Spindler R, Wolkers WF, Glasmacher B, Muller T. Cryopreservation and Quality Control of Mouse Embryonic Feeder Cells. Cryobiology. 2011;63(2):104-10.

Bernemann I, Mueller T, Blasczyk R, Glasmacher B, Hofmann N. Colonization of Collagen Scaffolds by Adipocytes Derived from Mesenchymal Stem Cells of the Common Marmoset Monkey. Biochem Biophys Res Commun. 2011;411(2):317-22.

Bernemann I, Spindler R, Manuchehrabadi N, Choi J, Wolkers W, Bischof J, Glasmacher B: Long-term storage of engineered tissue: Visualisation of CPA diffusion in collagen scaffolds. Histology and Histopathology 2011; 26 (1):33

Hofmann N, Bernemann I, Pogozhykh D, Glasmacher B. Development of systematic parameter optimization for cryopreservation regimens for cellular suspensions. Problems of Cryobiology. 2011;21(4), 353-63.

Hofmann N, Pogozhykh D, Bernemann I, Zingerov B, Evertz F, Glasmacher B. µ-freezing device for the development of optimal cryopreservation protocols for stem cells. DKV-Jahresbericht 38, Band 1, 2011, ISBN 978-3-932715-47-1.

Wiedemann A, Schwarmborn J, Honndorf S, Bernemann I, Figureido C, Scharmbach A, Blasczyk R, Müller T. Induced pluripotent stem cells of the common marmoset monkey display high cellular plasticity.Regenerative Medicine. 2011;6(6s2), 244. DOI 10.2217/rme.11.16.

Pogozhykh D, Hofmann N, Müller T, Glasmacher B: Development of optimal cryopreservation protocol for suspensions of MSCs with application of systematic parameter optimization. Regenerative Medicine. 2011;6(6s2), 229. DOI 10.2217/rme.11.16.

2010

Bernemann I, Manuchehrabadi N, Spindler R, Choi J, Wolkers WF, Bischof JC, Glasmacher B. Diffusion of Dimethyl Sulfoxide in Tissue Engineered Collagen Scaffolds Visualized by Computer Tomography. Cryo Letters. 2010;31(6):493-503.

Wolkers WF, Diekmann U, Müller T, Spindler R, Glasmacher B. Cryomicroscopy and FTIR Studies on Gamma Treated Mouse Embryonic Fibroblast Feeder Cells during Freezing. CryoLetters. 2010;31(2):192-3.

Bernemann I, Deiwick A, Hofmann N, Grüne M, Koch L, Glasmacher B: Cell seeding of collagen scaffolds via cell printing. Regenerative Medicine. 2010;6(6s2),43. DOI 10.2217/rme.11.16.

Bernemann I, Spindler R, Manuchehrabadi N, Choi J, Wolkers W, Bischof J, Glasmacher B. Visualization of DMSO diffusion in engineering constructs for long-term storage. Regenerative Medicine. 2011;6(6s2),343. DOI 10.2217/rme.11.16.

Diekmann U, Wolkers W F, Spindler R, Glasmacher B, Müller T. Effects of cryopreservation on gamma-irradiated mouse embryonic feeder cells, CryoLetters 2010; 31(2): 174-175.

Sun H, Hofmann N, Glasmacher B. Application of Compatible Solute within Croypreservation of Human Endothelial Cells. CryoLetters. 2010;31(2):191.

Spindler R, Glasmacher B. Cryopreservation of Human Pulmonary Endothelial Cells: Determination of Osmotic Parameters. CryoLetters. 2010;31(2):189-90.

Spindler R, Wolkers WF, Glasmacher B. Interaction of dimethyl sulfoxide and ethylene glycol with cells during freezing. CryoLetters 2010; 31(2): 178.

Sehl C, Freimark D, Weber C, Hudel K, Hofmann N, Glasmacher B, Czermak P. Entwicklung eines GMP-gerechten Verfahrens zur Kryokonservierung von Zellen und zellbasierten Implantaten für die regenerative Medizin. DKV-Jahresbericht 37. 2010;Band 1.

Bernemann I, Spindler R, Manuchehrabadi N, Choi JH, Wolkers W, Bischof J, Glasmacher B. Dimethyl Sulfoxide Diffusion in Tissue-Engineered Collagen Scaffolds Visualized by Computer Tomography. CryoLetters. 2010;31(2):193-4.

2009

Spindler R, Wolkers WF, Glasmacher B. Effect of Me(2)So on Membrane Phase Behavior and Protein Denaturation of Human Pulmonary Endothelial Cells Studied by in Situ Ftir Spectroscopy. J Biomech Eng. 2009;131(7):074517. Epub 2009/07/31.

Bernemann I, Sun H, Hofmann N, Glasmacher B. Increase of Cell Survival of Native Tissues and Tissue Engineered Products by Optimisation of the Cryopreservation Process. CryoLetters. 2009;30(2):156.

Evertz F, Blume H, Glasmacher B. Mirco-Cryopreservation. Int J Artif Organs. 2009;32(7):412-.

Hofmann N, Stoll C, Bernemann I, Glasmacher B. Improved Cryopreservation of Human Pulmonary Endothelial Cells (HPEMC-ST1.6R): Methods of Analysis Influence Cell Survival Rates. CryoLetters. 2009;30(1):82-3.

Spindler R, Glasmacher B. Kryomikroskopie. Eine Methode zur Visualisierung von Gefrierprozessen. KI Kälte-Luft-Klimatechnik 4. 2009:28-31.

Sun H, Hofmann N, Glasmacher B. Proline Improves the Cryopreservation of Human Endothelial Cells for Te. Int J Artif Organs. 2009;32(7):412.

Sun H, Hofmann N, Glasmacher B. 97. Biomolecules for the improvement of cryopreservation of human endothelial cells. Cryobiology. 2009;59(3):397.

Bernemann I, Deiwick A, Hofmann N, Grune M, Koch L, Chichkov B, Glasmacher B. Laser-Induced Cell Seeding of Collagen Scaffolds. Int J Artif Organs. 2009;32(7):416.

Bernemann I, Deiwick A, Marx C, Muller T, Glasmacher B, Hofmann N. Adipogenic differentiation of mesenchymal stem cells of the common marmoset monkey in collagen scaffolds. Hum Gene Ther. 2009;20(11):1533-4.

Evertz F, Deiwick A, Bernemann I, Hofmann N, Glasmacher B: Micro-freezing suitable for stem cell cryopreservation. Hum Gene Ther. 2009;20(11):1417-545. Doi: 10.1089/hum.2009.0926.

Hofmann N, Grein T, Weber C, Glasmacher B, Czermak P. Cryopreservation of hMSC-TERT without DMSO and Serum. Hum Gene Ther. 2009;20(11):1417-545. Doi: 10.1089/hum.2009.0926.

2008

Hofmann N, Sun H, Bernemann I, Glasmacher B. 73. Influence of temperature profile and CPA distribution on cryopreservation of native tissue. Cryobiology. 2008;57(3):330.

Hofmann N, Bernemann I, Glasmacher B. Cryopreservation of Tissue and Tissue Engineered Products. Int J Artif Organs. 2008;31(7):583.

Evertz F, Szentivanyi A, Bernemann I, Hofmann N, Glasmacher B. 107. Development of a new controlled rate micro-freezing device for systematic parameter optimization in cryopreservation. Cryobiology. 2008;57(3):337.

Bernemann I, Hofmann N, Szentivanyi A, Kuberka M, Glasmacher B. Optimierung von Kryokonservierungsprotokollen: Systematische Parameteranalyse. KI Kälte-Luft-Klimatechnik 4. 2008;KI-01-02/2008:24-7.

Bernemann I, Hofmann N, Spindler R, Szentivanyi A, Glasmacher B. Strategy to improve cryopreservation protocols. CryoLetters. 2008;29(1):83.

Bernemann I, Hofmann N, Glasmacher B. 106. Optimization of the thawing process improves the cryopreservation outcome of cell suspensions and tissue engineered products. Cryobiology. 2008;57(3):337.

Bernemann I, Hofmann N, Glasmacher B. Optimization of Thawing Parameters to Improve Cryopreservation of Cells and Tissue Engineering Products. Int J Artif Organs. 2008;31(7):637.

Stoll C, Hofmann N, Bernemann I, Glasmacher B. 109. Systematic optimisation of parameters for cryopreservation of human pulmonal endothelial cells (HPMEC): Difference in cell survival rates analyzed by recultivation vs. trypanblue staining. Cryobiology. 2008;57(3):337-8.

Spindler R, Hofmann N, Glasmacher B. 108. Controlled ice nucleation during cryopreservation. Cryobiology. 2008;57(3):337.

2007

Hofmann N, Bernemann I, Glasmacher B. Kryokonservierung von Gewebe. DKV-Jahresbericht 34. 2007;Band 1-I3.

Bernemann I, Hofmann N, Szentivanyi A, Glasmacher B. 45. Strategy to improve cryopreservation protocols: A systematic parametric analysis for suspended cells. Cryobiology. 2007;55(3):338.

Bernemann I, Hofmann N, Szentivanyi A, Glasmacher B. A systematic parametric analysis to improve cryopreservation of cells in suspension. Int J Artif Organs. 2007;30(8):712.

Books

Gryshkov O. PhD Thesis: High voltage encapsulation of multipotent stromal cells in alginate. 2014, Medical school Hannover.

Wienecke S. PhD Thesis: Directional solidificated hierarchically layered structures. 2014, Leibniz Universität Hannover.

Chakradeo T. PhD Thesis: Strategies for functionalization of electrospun fibers. 2013, Medical school Hannover.

Spindler R. PhD Thesis: Einfluss der Nukleationstemperatur und der Konzentration an Frierschutzmitteln auf die Kryokonservierung humaner Zellen. 2012, LUH.

Ehlers A, Baumann F, Spindler R, Glasmacher B, Rosenhahn B. Pca Enhanced Training Data for Adaboost. In: Real P, Diaz-Pernil D, Molina-Abril H, Berciano A, Kropatsch W, editors. Computer Analysis of Images and Patterns: Springer Berlin Heidelberg; 2011. p. 410-419.

Unit 10.5 - Biocompatibility

2015

Loos A. 11 - Biocompatibility Testing and Marketing Authorisation Of degradable Magnesium Implants. In: Narayanan TSNS, Lee I-SP-H, editors. Surface Modification of Magnesium and Its Alloys for Biomedical Applications. Oxford: Woodhead Publishing; 2015. p. 331-53.

Loos A, Bischoff P.Standardisierung im Bereich Tissue Engineering - Ein Blick auf die aktuelle Situation”. Bioforum. 2015, 38 (1), 17-19

2013

Sowa-Söhle Eveline N, Schwenke A, Wagener P, Weiss A, Wiegel H, Sajti Csaba L, Haverich A, Barcikowski S, Loos A. Antimicrobial Efficacy, Cytotoxicity, and Ion Release of Mixed Metal (Ag, Cu, Zn, Mg) Nanoparticle Polymer Composite Implant Material. BioNanoMaterials2013. p. 217.

2012

Glasmacher B, Krolitzki B, Müller M, Loos A, Löbler M. „Blutverträglichkeit von Kunststoffen“, Kunststoffe in der Medizintechnik, VDI Verlag GmbH, 2012, 273-290, ISBN 978-3-18-234319-6.

Hahn A, Fuhlrott J, Loos A, Barcikowski S. Cytotoxicity and Ion Release of Alloy Nanoparticles. J Nanopart Res. 2012;14(1):1-10.

2009

Ghodsizad A, Niehaus M, Kogler G, Martin U, Wernet P, Bara C, Khaladj N, Loos A, Makoui M, Thiele J, Mengel M, Karck M, Klein HM, Haverich A, Ruhparwar A. Transplanted Human Cord Blood-Derived Unrestricted Somatic Stem Cells Improve Left-Ventricular Function and Prevent Left-Ventricular Dilation and Scar Formation after Acute Myocardial Infarction. Heart. 2009;95(1):27-35.

Fuhlrott J.; Loos A.; Glasmacher B.; Löbler M.: Endozytose und Zytotoxizität von Nanopartikeln. BIOmaterialien, 2009;10 (3/4):109.

2007

Loos A, Rohde R, Haverich A, Barlach S. In Vitro and in Vivo Biocompatibility Testing of Absorbable Metal Stents. Macromolecular Symposia. 2007;253(1):103-8.

2006

Waksman R, Pakala R, Kuchulakanti PK, Baffour R, Hellinga D, Seabron R, Tio FO, Wittchow E, Hartwig S, Harder C, Rohde R, Heublein B, Andreae A, Waldmann KH, Haverich A. Safety and Efficacy of Bioabsorbable Magnesium Alloy Stents in Porcine Coronary Arteries. Catheter Cardiovasc Interv. 2006;68(4):607-17; discussion 18-9.

2003

Heublein B, Rohde R, Kaese V, Niemeyer M, Hartung W, Haverich A. Biocorrosion of Magnesium Alloys: A New Principle in Cardiovascular Implant Technology? Heart. 2003;89(6):651-6.

2002

Heublein B, Evagorou EG, Rohde R, Ohse S, Meliss RR, Barlach S, Haverich A. Polymerized Degradable Hyaluronan--a Platform for Stent Coating with Inherent Inhibitory Effects on Neointimal Formation in a Porcine Coronary Model. Int J Artif Organs. 2002;25(12):1166-73.

Unit 10.6 - Clinical Trial Management

2016

Samuels S, Balint B, von der Leyen H, Hupe P, de Koning L, Kamoun C, Luscap-Rondof W, Wittkop U, Bagrintseva K, Popovic M, Kereszt A, Berns E, Kenter GG, Jordanova ES, Kamal M, Scholl S. Precision medicine in cancer: challenges and recommendations from an EU-funded cervical cancer biobanking study. Br J Cancer. 2016;115(12):1575-83.

Lindhardt M, Persson F, Currie G, Pontillo C, Beige J, Delles C, von der Leyen H, Mischak H, Navis G, Noutsou M, Ortiz A, Ruggenenti PL, Rychlik I, Spasovski G, Rossing P. Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial. BMJ Open. 2016;6(3):e010310.

Deterding K, Spinner CD, Schott E, Welzel TM, Gerken G, Klinker HH, Spengler U, Wiegand J, zur Wiesch JS, Pathil A, Cornberg M, Umgelter A, Zollner C, Zeuzem S, Papkalla A, Weber K, Hardtke S, von der Leyen H, Koch A, von Witzendorff D, Manns MP, Wedemeyer H. Six weeks of sofosbuvir/ledipasvir treatment of acute hepatitis C virus genotype 1 monoinfection: Final results of the The German HepNet Acute HCV IV Study. Hepatology. 2016;63(1 Supp):416a-7a.

2015

>Ngo C, Samuels S, Bagrintseva K, Slocker A, Hupe P, Kenter G, Popovic M, Samet N, Tresca P, von der Leyen H, Deutsch E, Rouzier R, Belin L, Kamal M, Scholl S, www.raids-fp7.eu RAc. From prospective biobanking to precision medicine: BIO-RAIDs - an EU study protocol in cervical cancer. BMC Cancer. 2015;15:842.

Ngo C, Samuels S, Bagrintseva K, Slocker A, Hupe P, Kenter G, Popovic M, Samet N, Tresca P, von der Leyen H, Deutsch E, Rouzier R, Belin L, Kamal M, Scholl S, www.raids-fp7.eu RAc. From Prospective Biobanking to Precision Medicine: Bio-Raids - an Eu Study Protocol in Cervical Cancer. BMC Cancer. 2015;15:842.

Barthold M, Fischer I, Schröder C, Albrecht U, Rohde B. Klinische Forschungsvorhaben mit Medizinprodukten: Vorgehen einer akademischen Institution. Deut Z Klin Forsch 5, 2015, 34-38.

2014

Siwy J, Schanstra JP, Argiles A, Bakker SJ, Beige J, Boucek P, Brand K, Delles C, Duranton F, Fernandez-Fernandez B, Jankowski ML, Al Khatib M, Kunt T, Lajer M, Lichtinghagen R, Lindhardt M, Maahs DM, Mischak H, Mullen W, Navis G, Noutsou M, Ortiz A, Persson F, Petrie JR, Roob JM, Rossing P, Ruggenenti P, Rychlik I, Serra AL, Snell-Bergeon J, Spasovski G, Stojceva-Taneva O, Trillini M, von der Leyen H, Winklhofer-Roob BM, Zurbig P, Jankowski J. Multicentre Prospective Validation of a Urinary Peptidome-Based Classifier for the Diagnosis of Type 2 Diabetic Nephropathy. Nephrol Dial Transplant. 2014;29(8):1563-70. Epub 2014/03/05.

2012

Pincha M, Sundarasetty BS, Salguero G, Gutzmer R, Garritsen H, Macke L, Schneider A, Lenz D, Figueiredo C, Blasczyk R, Ruggiero E, Schmidt M, von Kalle C, Puff C, Modlich U, von der Leyen H, Wicke DC, Ganser A, Stripecke R. Identity, Potency, in Vivo Viability, and Scaling up Production of Lentiviral Vector-Induced Dendritic Cells for Melanoma Immunotherapy. Hum Gene Ther Methods. 2012;23(1):38-55.

Wicke DC, von der Leyen H. Behandlung der Restenose bei koronarer Herzkrankheit mittels NO-Synthase-Gentherapie (CAR-MP583): Ergebnisse der REGENT-I-Extension Studie. Deutsche Z Klin Forschung. 2012;5/6:34-7.

2011

Walter C, Rohde B, Wicke DC, Pohler C, Luhrmann A, von der Leyen H. [Regulatory Framework of Innovative Therapies : From Bench to Bedside]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2011;54(7):803-10. Regulatorischer Rahmen fur neuartige Therapien. Vom Labor zur klinischen Prufung.

2009

Voelkel C, Lührmann A, Baum C, von der Leyen HE. Retrovirus mediated hematopoietic gene therapy: A European regulatory perspective with special focus on the situation in Germany. Cell Ther Transplant. 2009;1:e.000044.01. doi:10.3205/ctt-2009-en-000044.01

2007

H. von der Leyen, C.L. Voelkel, Hannover Clinical Trial Center - Zentrale Schnittstelle für das Management innovativer klinischer Forschung, Biospektrum, 7-2007, 801-2.

Unit 10.7 - Ethical and Legal Dimensions

2016

Lander J, Hainz T, Hirschberg I, Bossert S, Strech D. Do Public Involvement Activities in Biomedical Research and Innovation Recruit Representatively? A Systematic Qualitative Review. Public Health Genomics. 2016;19(4):193-202.

Kaye J, Briceno Moraia L, Curren L, Bell J, Mitchell C, Soini S, Hoppe N, Oien M, Rial-Sebbag E. Consent for Biobanking: The Legal Frameworks of Countries in the BioSHaRE-EU Project. Biopreserv Biobank. 2016;14(3):195-200.

Hoppe N. Privacy Laws and Biobanking in Germany. J Law Med Ethics. 2016;44(1):35-44.

Hainz T, Bossert S, Strech D. Collective agency and the concept of 'public' in public involvement: A practice-oriented analysis. BMC Med Ethics. 2016;17:1.

Chin WW, Wieschowski S, Prokein J, Illig T, Strech D. Ethics Reporting in Biospecimen and Genetic Research: Current Practice and Suggestions for Changes. PLoS Biol. 2016;14(8):e1002521.

2015

Webborn N, Williams A, McNamee M, Bouchard C, Pitsiladis Y, Ahmetov I, Ashley E, Byrne N, Camporesi S, Collins M, Dijkstra P, Eynon N, Fuku N, Garton FC, Hoppe N, Holm S, Kaye J, Klissouras V, Lucia A, Maase K, Moran C, North KN, Pigozzi F, Wang G. Direct-to-consumer genetic testing for predicting sports performance and talent identification: Consensus statement. Br J Sports Med. 2015;49(23):1486-91.

Strech D, Deh U, Schmitz S, et al. Workshop - Ökonomische Steuerungsmechanismen: Beispiel Hämatologie und Onkologie. Oncology Research and Treatment 2015;38 Suppl 1:3-22.

Medical care for older people – what evidence do we need? German National Academy of Sciences Leopoldina, acatech – National Academy of Science and Engineering and Union of the German Academies of Sciences and Humanities. 2015.

Strech D, Kahrass H, Hirschberg I. Research Guideline Recommendations for Broad Consent Forms in Biobank Research and How They Are Currently Addressed in Practice. Am J Bioeth. 2015;15(9):60-3. Epub 2015/08/26.

Strech D. Ethical Review of Biobank Research: Should Recs Review Each Release of Material from Biobanks Operating under an Already-Approved Broad Consent and Data Protection Model? Eur J Med Genet. 2015;58(10):545-9. Epub 2015/09/24.

Seitzer F, Kahrass H, Neitzke G, Strech D. The Full Spectrum of Ethical Issues in the Care of Patients with Als: A Systematic Qualitative Review. J Neurol. 2015.

Moraia LB, Kaye J, Tasse AM, Knoppers BM, Mitchell C, Soini S, Hoppe N, Wallace SE, Øien M. A Comparative Analysis of the Requirements for the Use of Data in Biobanks Based in Finland, Germany, the Netherlands, Norway and the United Kingdom. Medical Law International. 2015.

Meerpohl JJ, Schell LK, Bassler D, Gallus S, Kleijnen J, Kulig M, La Vecchia C, Marusic A, Ravaud P, Reis A, Schmucker C, Strech D, Urrutia G, Wager E, Antes G, consortium Op. Evidence-Informed Recommendations to Reduce Dissemination Bias in Clinical Research: Conclusions from the Open (Overcome Failure to Publish Negative Findings) Project Based on an International Consensus Meeting. BMJ Open. 2015;5(5):e006666.

Marckmann G, Schmidt H, Sofaer N, Strech D. Putting Public Health Ethics into Practice: A Systematic Framework. Front Public Health. 2015;3:23. Epub 2015/02/24.

Grewal J, Hoppe N. Don't Forget the Orphans. Eur J Health Law. 2015;22(2):107-11.

Hoppe N. (in print) Privacy Laws and Biobanking in Germany. The Journal of Law, Medicine & Ethics.

Webborn N, et al. (in print) Direct-to-Consumer Genetic Testing for Predicting Sports Performance and Talent Identification. British Journal of Sports Medicine.

Hübner D. Gerechtigkeit. In: Sturma D, Heinrichs B, editors. Handbuch Bioethik: Stuttgart/Weimar. JB Metzler. 2015; p. 44-50.

Hübner D. Some Remarks Concerning Free Will and Evolutionary Theory. American Journal of Bioethics - Neuroscience. 2015;6(2):24-26. doi: 10.1080/21507740.2015.1025998

Lohse S, Grewal J. Book review: Governing Biobanks: Understanding the Interplay between Law and Practice. SCRIPTed. 2015; 12(1):70-74. doi: 10.2966/scrip.120115.70

2014

Strech D, Metz C, Knuppel H. Do Editorial Policies Support Ethical Research? A Thematic Text Analysis of Author Instructions in Psychiatry Journals. PLoS One. 2014;9(6):e97492. Epub 2014/06/06.

Strech D. Patienten-/Probandenrekrutierung Und Kontaktaufnahme. In: Lenk C, Duttge G, Fangerau H, editors. Handbuch Ethik Und Recht Der Forschung Am Menschen: Springer Berlin Heidelberg; 2014. p. 213-6.

Strech D. Wissenschaftlicher Und Sozialer Wert. In: Lenk C, Duttge G, Fangerau H, editors. Handbuch Ethik Und Recht Der Forschung Am Menschen: Springer Berlin Heidelberg; 2014. p. 299-303.

Schrem H, Platsakis AL, Kaltenborn A, Koch A, Metz C, Barthold M, Krauth C, Amelung V, Braun F, Becker T, Klempnauer J, Reichert B. Value and Limitations of the Bar-Score for Donor Allocation in Liver Transplantation. Langenbecks Arch Surg. 2014;399(8):1011-9.

Mueller KF, Briel M, Strech D, Meerpohl JJ, Lang B, Motschall E, Gloy V, Lamontagne F, Bassler D. Dissemination Bias in Systematic Reviews of Animal Research: A Systematic Review. PLoS One. 2014;9(12):e116016.

Mertz M, Strech D. Systematic and Transparent Inclusion of Ethical Issues and Recommendations in Clinical Practice Guidelines: A Six-Step Approach. Implement Sci. 2014;9:184.

Lenk C, Hoppe N. Research Governance in Placebo-Controlled Trials: Is the Ema/Ich Position Consistent in Itself and in Accordance with the Declaration of Helsinki? Medical Law International. 2014;14(3):115-32.

Lander J, Hainz T, Hirschberg I, Strech D. Current Practice of Public Involvement Activities in Biomedical Research and Innovation: A Systematic Qualitative Review. PLoS One. 2014;9(12):e113274.

Klose J, Klose MA, Metz C, Lehner F, Manns MP, Klempnauer J, Hoppe N, Schrem H, Kaltenborn A. Outcome Stagnation of Liver Transplantation for Primary Sclerosing Cholangitis in the Model for End-Stage Liver Disease Era. Langenbecks Arch Surg. 2014;399(8):1021-9.

Kaye J, Hurles M, Griffin H, Grewal J, Bobrow M, Timpson N, Smee C, Bolton P, Durbin R, Dyke S, Fitzpatrick D, Kennedy K, Kent A, Muddyman D, Muntoni F, Raymond LF, Semple R, Spector T, Uk K. Managing Clinically Significant Findings in Research: The Uk10k Example. Eur J Hum Genet. 2014;22(9):1100-4.

Hübner D. Kultürlichkeit Statt Natürlichkeit: Ein Vernachlässigtes Argument in Der Bioethischen Debatte Um Enhancement Und Anthropotechnik. Jahrbuch für Wissenschaft und Ethik2014. p. 25.

Hoppe N, Miola J. Innovation in Medicine through Degeneration in Law? A Critical Perspective on the Medical Innovation Bill. Medical Law International. 2014.

Hoppe N, Kwisda K. Geistiges Eigentum. In: Lenk C, Duttge G, Fangerau H, editors. Handbuch Ethik Und Recht Der Forschung Am Menschen: Springer Berlin Heidelberg; 2014. p. 159-62.

Hirschberg I, Kahrass H, Strech D. International Requirements for Consent in Biobank Research: Qualitative Review of Research Guidelines. J Med Genet. 2014;51(12):773-81.

Hainz T, Strech D. Which Public to Involve? More Reflection on Collective Agency and Sufficient Representativeness Is Needed. The American Journal of Bioethics. 2014;14(6):31-3.

Hoppe N, Kwisda K. Oviedo Konvention. In: Lenk C, Duttge G, Fangerau H, editors. Handbuch Ethik Und Recht Der Forschung Am Menschen: Springer Berlin Heidelberg; 2014.

Hoppe N, Miola J. Medical Law and Medical Ethics. 2014. Cambridge University Press. ISBN: 9781107612372

2013

Robienski J, Hoppe N. Aktuelle Medizinrechtliche Und -Ethische Herausforderungen Der Pathologie. Der Pathologe. 2013;34(1):9-15.

Knüppel H, Metz C, Meerpohl JJ, Strech D. How Psychiatry Journals Support the Unbiased Translation of Clinical Research. A Cross-Sectional Study of Editorial Policies. PLoS ONE. 2013;8(10):e75995.

Knuppel H, Mertz M, Schmidhuber M, Neitzke G, Strech D. Inclusion of Ethical Issues in Dementia Guidelines: A Thematic Text Analysis. PLoS Med. 2013;10(8):e1001498.

Hoppe N. From Omics and Etics to Policy and Ethics: Regulating Evolution. Front Genet. 2013;4:172.

Hoppe N. The Issue with Tissue: Why Making Human Biomaterials Available for Research Purposes Is Still Controversial. Diagnostic Histopathology. 2013;19(9):315-21.

Hirschberg I, Knuppel H, Strech D. Practice Variation across Consent Templates for Biobank Research. A Survey of German Biobanks. Front Genet. 2013;4:240. Epub 2013/12/03.

Fuchs M, Heinemann T, Heinrichs B, Hübner D, Kipper J, Rottländer K, Runkel T, Spranger TM, Vermeulen V, Völker-Albert M. Kagakugijutsukenkyuno- rinri-nyomon (Research Ethics – An Introduction), Tokio, Chisen Verl. 2013. XXXVII, 405 S.

2012

Strech D. Normative Arguments and New Solutions for the Unbiased Registration and Publication of Clinical Trials. J Clin Epidemiol. 2012;65(3):276-81.

Kaye J, Meslin EM, Knoppers BM, Juengst ET, Deschenes M, Cambon-Thomsen A, Chalmers D, De Vries J, Edwards K, Hoppe N, Kent A, Adebamowo C, Marshall P, Kato K. Research Priorities. Elsi 2.0 for Genomics and Society. Science. 2012;336(6082):673-4. Epub 2012/05/15.

Raspe H, Hüppe A, Strech D, Taupitz J. Empfehlungen zur Begutachtung klinischer Studien durch Ethik-Kommissionen. Vol 2, Deutscher Ärzteverlag, 2012, ISBN 978-3-7691-1305-1.

Unit Differentiation, Supgroup Clinical Biochemistry, 2007-2013

Naujok O, Bandou Y, Shikama Y, Funaki M, Lenzen S. Effect of substrate rigidity in tissue culture on the function of insulin-secreting INS-1E cells. J Tissue Eng Regen Med. 2014. Epub 2014/01/09.

Naujok O, Lentes J, Diekmann U, Davenport C, Lenzen S. Cytotoxicity and activation of the Wnt/beta-catenin pathway in mouse embryonic stem cells treated with four GSK3 inhibitors. BMC Res Notes. 2014;7(1):273. Epub 2014/05/02.

Diekmann U, Naujok O, Blasczyk R, Müller T. Embryonic stem cells of the non-human primate Callithrix jacchus can be differentiated into definitive endoderm by Activin-A but not IDE-1/2. J Tissue Eng Regen Med. 2013. Epub 2013/02/19.

Elsner M, Naujok O, Jorns A, Lenzen S. Comment on Binhai Ren et al. (2013; 15: 28-41): long-term reversal of diabetes in non-obese diabetic mice by liver-directed gene therapy. J Gene Med. 2013;15(8-9):306-8. Epub 2013/09/17.

Lortz S, Gurgul-Convey E, Naujok O, Lenzen S. Overexpression of the antioxidant enzyme catalase does not interfere with the glucose responsiveness of insulin-secreting INS-1E cells and rat islets. Diabetologia. 2013;56(4):774-82. Epub 2013/01/12.

Naujok O, Diekmann U, Lenzen S. Efficient generation of definitive endoderm from human embryonic stem cells by GSK3 beta inhibition and nodal signalling. Diabetologia. 2013;56:S93-S4.

Diekmann U, Elsner M, Fiedler J, Thum T, Lenzen S, Naujok O. MicroRNA Target Sites as Genetic Tools to Enhance Promoter- Reporter Specificity for the Purification of Pancreatic Progenitor Cells from Differentiated Embryonic Stem Cells. Stem Cell Rev. 2012. Epub 2012/11/01.

Naujok O, Lenzen S. [Pluripotent stem cells for cell replacement therapy of diabetes]. Dtsch Med Wochenschr. 2012;137(20):1062-6. Epub 2012/05/10. Pluripotente Stammzellen zur Zellersatztherapie des Diabetes mellitus.

Naujok O, Lenzen S. A Critical Re-Evaluation of CD24-Positivity of Human Embryonic Stem Cells Differentiated into Pancreatic Progenitors. Stem Cell Rev. 2012. Epub 2012/04/25. 

Plentz RR, Palagani V, Wiedemann A, Diekmann U, Glage S, Naujok O, Jorns A, Muller T. Islet microarchitecture and glucose transporter expression of the pancreas of the marmoset monkey display similarities to the human. Islets. 2012;4(2). Epub 2012/05/26. 

Elsner M, Terbish T, Jorns A, Naujok O, Wedekind D, Hedrich HJ, Lenzen S. Reversal of Diabetes Through Gene Therapy of Diabetic Rats by Hepatic Insulin Expression via Lentiviral Transduction. Mol Ther. 2012;20(5):918-26. Epub 2012/02/23. 

Naujok O, Burns C, Jones PM, Lenzen S. Insulin-producing surrogate beta-cells from embryonic stem cells: are we there yet? Mol Ther. 2011;19(10):1759-68. Epub 2011/08/11. 

Jörns A, Sennholz C, Naujok O, Lenzen S. Beta cell mass regulation in the rat pancreas through glucocorticoids and thyroid hormones. Pancreas. 2010;39(8):1167-72. Epub 2010/08/05. 

Naujok O, Kaldrack J, Taivankhuu T, Jorns A, Lenzen S. Selective removal of undifferentiated embryonic stem cells from differentiation cultures through HSV1 thymidine kinase and ganciclovir treatment. Stem Cell Rev. 2010;6(3):450-61. Epub 2010/04/23. 

Milsom MD, Schiedlmeier B, Bailey J, Kim MO, Li DD, Jansen M, Ali AM, Kirby M, Baum C, Fairbairn LJ, Williams DA. Ectopic HOXB4 overcomes the inhibitory effect of tumor necrosis factor-alpha on Fanconi anemia hematopoietic stem and progenitor cells. Blood. 2009;113(21):5111-20. 

Naujok O, Francini F, Picton S, Bailey CJ, Lenzen S, Jorns A. Changes in gene expression and morphology of mouse embryonic stem cells on differentiation into insulin-producing cells in vitro and in vivo. Diabetes Metab Res Rev. 2009;25(5):464-76. Epub 2009/05/09. 

Chan KM, Bonde S, Klump H, Zavazava N. Hematopoiesis and immunity of HOXB4-transduced embryonic stem cell-derived hematopoietic progenitor cells. Blood. 2008;111(6):2953-61. 

Naujok O, Francini F, Jorns A, Lenzen S. An efficient experimental strategy for mouse embryonic stem cell differentiation and separation of a cytokeratin-19-positive population of insulin-producing cells. Cell Prolif. 2008;41(4):607-24. Epub 2008/07/12. 

Naujok O, Francini F, Picton S, Jörns A, Bailey CJ, Lenzen S. A new experimental protocol for preferential differentiation of mouse embryonic stem cells into insulin-producing cells. Cell Transplant. 2008;17(10-11):1231-42. Epub 2009/02/03. 

Unit Embyonic Stem Cells, 2007 - 2012

6a

Hanazawa K, Mueller T, Becker T, Heistermann M, Behr R, Sasaki E. Minimally invasive transabdominal collection of preimplantation embryos from the common marmoset monkey (Callithrix jacchus). Theriogenology. 2012;78(4):811-6. Epub 2012/05/15.

Plentz RR, Palagani V, Wiedemann A, Diekmann U, Glage S, Naujok O, Jorns A, Muller T. Islet microarchitecture and glucose transporter expression of the pancreas of the marmoset monkey display similarities to the human. Islets. 2012;4(2):123-9. Epub 2012/05/26

Bernemann I, Mueller T, Blasczyk R, Glasmacher B, Hofmann N. Colonization of collagen scaffolds by adipocytes derived from mesenchymal stem cells of the common marmoset monkey. Biochem Biophys Res Commun. 2011;411(2):317-22. 

Diekmann U, Spindler R, Wolkers WF, Glasmacher B, Muller T. Cryopreservation and quality control of mouse embryonic feeder cells. Cryobiology. 2011;63(2):104-10.

Müller T, Hupfeld T, Roessler J, Simoni M, Gromoll J, Behr R. Molecular cloning and functional characterization of endogenous recombinant common marmoset monkey (Callithrix jacchus) follicle-stimulating hormone. J Med Primatol. 2011;40(2):111-9. Epub 2010/11/04.

Wurm M, Gross B, Sgodda M, Standker L, Muller T, Forssmann WG, Horn PA, Blasczyk R, Cantz T. Improved lentiviral gene transfer into human embryonic stem cells grown in co-culture with murine feeder and stroma cells. Biol Chem. 2011;392(10):887-95. Epub 2011/08/05. 

Wurm M, Schambach A, Lindemann D, Hanenberg H, Standker L, Forssmann WG, Blasczyk R, Horn PA. The influence of semen-derived enhancer of virus infection on the efficiency of retroviral gene transfer. Journal of Gene Medicine. 2010;12(2):137-46. Epub 2010/01/07. 

Fleischmann G, Muller T, Blasczyk R, Sasaki E, Horn PA. Growth characteristics of the nonhuman primate embryonic stem cell line cjes001 depending on feeder cell treatment. Cloning Stem Cells. 2009;11(2):225-33. Epub 2009/06/16. 

Müller T, Fleischmann G, Eildermann K, Matz-Rensing K, Horn PA, Sasaki E, Behr R. A novel embryonic stem cell line derived from the common marmoset monkey (Callithrix jacchus) exhibiting germ cell-like characteristics. Human Reproduction. 2009;24(6):1359-72. Epub 2009/03/03. 

Wurm M, Tischer S, Immenschuh S, Blasczyk R, Eiz-Vesper B. The predicted protein structures of the novel DRB1*0717 and DRB1*0701 are highly related. Tissue Antigens. 2009;74(5):460-2. Epub 2009/10/23. 

6b

Barkhausen T, Tschernig T, Rosenstiel P, van Griensven M, Vonberg RP, Dorsch M, Mueller-Heine A, Chalaris A, Scheller J, Rose-John S, Seegert D, Krettek C, Waetzig GH. Selective blockade of interleukin-6 trans-signaling improves survival in a murine polymicrobial sepsis model. Crit Care Med. 2011;39(6):1407-13. Epub 2011/02/22. 

Held N, Smits BM, Gockeln R, Schubert S, Nave H, Northrup E, Cuppen E, Hedrich HJ, Wedekind D. A mutation in Myo15 leads to Usher-like symptoms in LEW/Ztm-ci2 rats. PLoS One. 2011;6(3):e15669. Epub 2011/04/12. 

Northrup E, Eisenblatter R, Glage S, Rudolph C, Dorsch M, Schlegelberger B, Hedrich HJ, Zschemisch NH. Loss of Dnd1 facilitates the cultivation of genital ridge-derived rat embryonic germ cells. Exp Cell Res. 2011;317(13):1885-94. Epub 2011/05/17. 

Dorsch M, Wedekind D. Cryopreservation and orthotopic transplantation of rat ovaries. Immunotherapy of Cancer: Methods and Protocols. 2010;597:301-10. Epub 2009/12/17. 

Jörns A, Rath KJ, Terbish T, Arndt T, Meyer Zu Vilsendorf A, Wedekind D, Hedrich HJ, Lenzen S. Diabetes prevention by immunomodulatory FTY720 treatment in the LEW.1AR1-iddm rat despite immune cell activation. Endocrinology. 2010;151(8):3555-65. Epub 2010/05/27. 

Zeckey C, Tschernig T, Hildebrand F, Frink M, Fromke C, Dorsch M, Krettek C, Barkhausen T. Macrophage-activating lipopeptide-2 exerts protective effects in a murine sepsis model. Shock. 2010;33(6):614-9. Epub 2009/11/27. 

Arndt T, Wedekind D, Weiss H, Tiedge M, Lenzen S, Hedrich HJ, Jorns A. Prevention of spontaneous immune-mediated diabetes development in the LEW.1AR1-iddm rat by selective CD8+ T cell transfer is associated with a cytokine shift in the pancreas-draining lymph nodes. Diabetologia. 2009;52(7):1381-90. Epub 2009/04/16. 

de Buhr MF, Hedrich HJ, Westendorf AM, Obermeier F, Hofmann C, Zschemisch NH, Buer J, Bumann D, Goyert SM, Bleich A. Analysis of Cd14 as a genetic modifier of experimental inflammatory bowel disease (IBD) in mice. Inflamm Bowel Dis. 2009;15(12):1824-36. Epub 2009/07/29. 

Janus LM, Smoczek A, Hedrich HJ, Bleich A. Risk assessment of minute virus of mice transmission during rederivation: detection in reproductive organs, gametes, and embryos of mice after in vivo infection. Biology of Reproduction. 2009;81(5):1010-5. Epub 2009/06/26. 

Velaga S, Herbrand H, Friedrichsen M, Jiong T, Dorsch M, Hoffmann MW, Forster R, Pabst O. Chemokine receptor CXCR5 supports solitary intestinal lymphoid tissue formation, B cell homing, and induction of intestinal IgA responses. Journal of Immunology. 2009;182(5):2610-9. Epub 2009/02/24. 

Unit Basic Mechanisms of Tissue Formation, 2007-2011

Heissler SM, Manstein DJ. Functional characterization of the human myosin-7a motor domain. Cell Mol Life Sci. 2012;69(2):299-311. Epub 2011/06/21. 

Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knolker HJ, Coluccio LM, Manstein DJ. Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity. J Biol Chem. 2011;286(34):29700-8. Epub 2011/06/18. 

Diensthuber RP, Muller M, Heissler SM, Taft MH, Chizhov I, Manstein DJ. Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. Febs Letters. 2011;585(5):767-71. Epub 2011/02/08. 

Heissler SM, Manstein DJ. Comparative kinetic and functional characterization of the motor domains of human nonmuscle myosin-2C isoforms. J Biol Chem. 2011;286(24):21191-202. Epub 2011/04/12. 

Preller M, Bauer S, Adamek N, Fujita-Becker S, Fedorov R, Geeves MA, Manstein DJ. Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V. J Biol Chem. 2011;286(40):35051-60. Epub 2011/08/16. 

Preller M, Chinthalapudi K, Martin R, Knolker HJ, Manstein DJ. Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study. J Med Chem. 2011;54(11):3675-85. Epub 2011/05/04. 

Reubold TF, Wohlgemuth S, Eschenburg S. Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure. 2011;19(8):1074-83. Epub 2011/08/11.

Forke R, Gruner KK, Knott KE, Auschill S, Agarwal S, Martin R, Bohl M, Richter S, Tsiavaliaris G, Fedorov R, Manstein DJ, Gutzeit HO, Knolker HJ. Total synthesis of biologically active alkaloids using transition metals. Pure and Applied Chemistry. 2010;82(11):1975-91.

Fedorov R, Bohl M, Tsiavaliaris G, Hartmann FK, Taft MH, Baruch P, Brenner B, Martin R, Knolker HJ, Gutzeit HO, Manstein DJ. The mechanism of pentabromopseudilin inhibition of myosin motor activity. Nat Struct Mol Biol. 2009;16(1):80-8. Epub 2009/01/06. 

Knoth T, Warburg K, Katzka C, Rai A, Wolf A, Brockmeyer A, Janning P, Reubold TF, Eschenburg S, Manstein DJ, Hubel K, Kaiser M, Waldmann H. The Ras pathway modulator melophlin A targets dynamins. Angew Chem Int Ed Engl. 2009;48(39):7240-5. Epub 2009/09/02. 

Martin R, Jager A, Bohl M, Richter S, Fedorov R, Manstein DJ, Gutzeit HO, Knolker HJ. Total synthesis of pentabromo- and pentachloropseudilin, and synthetic analogues--allosteric inhibitors of myosin ATPase. Angew Chem Int Ed Engl. 2009;48(43):8042-6. Epub 2009/09/10. 

Stolboushkina E, Nikonov S, Nikulin A, Blasi U, Manstein DJ, Fedorov R, Garber M, Nikonov O. Crystal structure of the intact archaeal translation initiation factor 2 demonstrates very high conformational flexibility in the alpha- and beta-subunits. J Mol Biol. 2008;382(3):680-91. Epub 2008/08/05. 

Taft MH, Hartmann FK, Rump A, Keller H, Chizhov I, Manstein DJ, Tsiavaliaris G. Dictyostelium myosin-5b is a conditional processive motor. J Biol Chem. 2008;283(40):26902-10. Epub 2008/07/25. 

Tsiavaliaris G, Fujita-Becker S, Durrwang U, Diensthuber RP, Geeves MA, Manstein DJ. Mechanism, regulation, and functional properties of Dictyostelium myosin-1B. J Biol Chem. 2008;283(8):4520-7. Epub 2007/12/20. 

Unit Biofluid Mechanics, 2007-2011

Gruene M, Deiwick A, Koch L, Schlie S, Unger C, Hofmann N, Bernemann I, Glasmacher B, Chichkov B. Laser Printing of Stem Cells for Biofabrication of Scaffold-Free Autologous Grafts. Tissue Eng Part C-Me. 2011;17(1):79-87.

Szentivanyi A, Chakradeo T, Zernetsch H, Glasmacher B. Electrospun cellular microenvironments: Understanding controlled release and scaffold structure. Adv Drug Deliv Rev. 2011;63(4-5):209-20.

Szentivanyi AL, Zernetsch H, Menzel H, Glasmacher B. A review of developments in electrospinning technology: new opportunities for the design of artificial tissue structures. Int J Artif Organs. 2011;34(10):986-97. Epub 2011/12/14.

Bernemann I, Manuchehrabadi N, Spindler R, Choi J, Wolkers WF, Bischof JC, Glasmacher B. Diffusion of Dimethyl Sulfoxide in Tissue Engineered Collagen Scaffolds Visualized by Computer Tomography. Cryoletters. 2010;31(6):493-503.

Zernetsch H, Chakradeo T, Szentivanyi A, Glasmacher B, Menzel H, Behrens P. Träger, Tracer und Depots: Submikron- und Nanotechnologie in der Biomedizin. Tagungsband „Kunststoffe in der Medizintechnik“, VDI Verlag GmbH, 2010, ISBN 978-3-18-234309-7, d-nb.info/1002351529.

Chakradeo T, Szentivanyi A, Glasmacher B. Growth Factor Release from Electrospun Polymer Fibres for Tissue Engineering. Int J Artif Organs. 2009;32(7):459.

Kriegs M, Kanellopoulou D, Koutsoukos PG, Mavrilas D, Glasmacher B. Development of a new combined test setup for accelerated dynamic pH-controlled in vitro calcification of porcine heart valves. Int J Artif Organs. 2009;32(11):794-801. Epub 2009/12/19.

Wadouh T, Mavrilas D, Krings M, Bach F-W, Glasmacher B. Explantatanalysen klinischer Herzklappenbioprothesen. BIOmaterialien. 2007;9(3):230.

Unit Biomaterials, 2007-2011

Henjes CR, Hungerbuhler S, Bojarski IB, Nolte I, Wefstaedt P. Comparison of multi-detector row computed tomography with echocardiography for assessment of left ventricular function in healthy dogs. Am J Vet Res. 2012;73(3):393-403. Epub 2012/03/01. 

Ismail AA, Wagner S, Murua Escobar H, Willenbrock S, Sterenczak KA, Samy MT, Abd El-Aal AM, Nolte I, Wefstaedt P. Effects of high-mobility group a protein application on canine adipose-derived mesenchymal stem cells in vitro. Vet Med Int. 2012;2012:752083. Epub 2012/03/27. 

Van der Heyden S, Croubels S, Gadeyne C, Ducatelle R, Daminet S, Murua Escobar H, Sterenczak K, Polis I, Schauvliege S, Hesta M, Chiers K. Influence of P-glycoprotein modulation on plasma concentrations and pharmacokinetics of orally administered prednisolone in dogs. Am J Vet Res. 2012;73(6):900-7. Epub 2012/05/25. 

Willenbrock S, Braun O, Baumgart J, Lange S, Junghanss C, Heisterkamp A, Nolte I, Bullerdiek J, Escobar HM. TNF-alpha induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A). Cytokine. 2012;57(2):210-20.

Duran MC, Willenbrock S, Barchanski A, Muller JM, Maiolini A, Soller JT, Barcikowski S, Nolte I, Feige K, Murua Escobar H. Comparison of nanoparticle-mediated transfection methods for DNA expression plasmids: efficiency and cytotoxicity. J Nanobiotechnology. 2011;9:47. Epub 2011/10/22. 

Fitting J, Killian D, Junghanss C, Willenbrock S, Murua Escobar H, Lange S, Nolte I, Barth S, Tur MK. Generation of recombinant antibody fragments that target canine dendritic cells by phage display technology. Vet Comp Oncol. 2011;9(3):183-95. Epub 2011/08/19.

Henjes CR, Nolte I, Wefstaedt P. Multidetector-row computed tomography of thoracic aortic anomalies in dogs and cats: patent ductus arteriosus and vascular rings. BMC Vet Res. 2011;7:57. Epub 2011/09/29.

Reimann-Berg N, Murua Escobar H, Kiefer Y, Mischke R, Willenbrock S, Eberle N, Nolte I, Bullerdiek J. Cytogenetic analysis of CpG-oligonucleotide DSP30 plus Interleukin-2-Stimulated canine B-Cell lymphoma cells reveals the loss of one X Chromosome as the sole abnormality. Cytogenet Genome Res. 2011;135(1):79-82. Epub 2011/08/04. 

Sterenczak KA, Kleinschmidt S, Wefstaedt P, Eberle N, Hewicker-Trautwein M, Bullerdiek J, Nolte I, Murua Escobar H. Quantitative PCR and immunohistochemical analyses of HMGB1 and RAGE expression in canine disseminated histiocytic sarcoma (malignant histiocytosis). Anticancer Res. 2011;31(5):1541-8. Epub 2011/05/28. 

Joetzke AE, Sterenczak KA, Eberle N, Wagner S, Soller JT, Nolte I, Bullerdiek J, Murua Escobar H, Simon D. Expression of the high mobility group A1 (HMGA1) and A2 (HMGA2) genes in canine lymphoma: analysis of 23 cases and comparison to control cases. Vet Comp Oncol. 2010;8(2):87-95. Epub 2010/06/29. 

Sterenczak KA, Joetzke AE, Willenbrock S, Eberle N, Lange S, Junghanss C, Nolte I, Bullerdiek J, Simon D, Murua Escobar H. High-mobility group B1 (HMGB1) and receptor for advanced glycation end-products (RAGE) expression in canine lymphoma. Anticancer Res. 2010;30(12):5043-8. Epub 2010/12/29.

Petersen S, Soller JT, Wagner S, Richter A, Bullerdiek J, Nolte I, Barcikowski S, Murua Escobar H. Co-transfection of plasmid DNA and laser-generated gold nanoparticles does not disturb the bioactivity of GFP-HMGB1 fusion protein. J Nanobiotechnology. 2009;7:6. Epub 2009/10/27.

Richter A, Hauschild G, Murua Escobar H, Nolte I, Bullerdiek J. Application of high-mobility-group-A proteins increases the proliferative activity of chondrocytes in vitro. Tissue Eng Part A. 2009;15(3):473-7. Epub 2008/08/30. 

Sterenczak KA, Willenbrock S, Barann M, Klemke M, Soller JT, Eberle N, Nolte I, Bullerdiek J, Murua Escobar H. Cloning, characterisation, and comparative quantitative expression analyses of receptor for advanced glycation end products (RAGE) transcript forms. Gene. 2009;434(1-2):35-42. Epub 2008/12/09. 

Wolf D, Lupke M, Wefstaedt P, Melichar K, Nolte I, Seifert H. [Optimising MR image quality of the canine nose]. Berl Münch Tierarztl Wochenschr. 2009;122(5-6):219-26. Epub 2009/06/13. Optimierung der Bildqualitat bei der MR-Darstellung der Hundenase. 

Altmann S, Lange S, Pommerencke J, Murua Escobar H, Bullerdiek J, Nolte I, Freund M, Junghanss C. High Mobility Group Box 1-Protein expression in canine haematopoietic cells and influence on canine peripheral blood mononuclear cell proliferative activity. Vet Immunol Immunopathol. 2008;126(3-4):367-72. Epub 2008/09/03. 

Beuing C, Soller JT, Muth M, Wagner S, Dolf G, Schelling C, Richter A, Willenbrock S, Reimann-Berg N, Winkler S, Nolte I, Bullerdiek J, Murua Escobar H. Genomic characterisation, chromosomal assignment and in vivo localisation of the canine high mobility group A1 (HMGA1) gene. BMC Genet. 2008;9:49. Epub 2008/07/25. 

Soller JT, Beuing C, Murua Escobar H, Winkler S, Reimann-Berg N, Drieschner N, Dolf G, Schelling C, Nolte I, Bullerdiek J. Chromosomal assignment of canine THADA gene to CFA 10q25. Mol Cytogenet. 2008;1:11. Epub 2008/06/05.

Jensen J, Simon D, Murua Escobar H, Soller JT, Bullerdiek J, Beelitz P, Pfister K, Nolte I. Anaplasma phagocytophilum in dogs in Germany. Zoonoses Public Health. 2007;54(2):94-101. Epub 2007/03/14.

Meyer B, Krisponeit D, Junghanss C, Murua Escobar H, Bullerdiek J. Quantitative expression analysis in peripheral blood of patients with chronic myeloid leukaemia: correlation between HMGA2 expression and white blood cell count. Leuk Lymphoma. 2007;48(10):2008-13. Epub 2007/10/06. 

Soller JT, Murua-Escobar H, Willenbrock S, Janssen M, Eberle N, Bullerdiek J, Nolte I. Comparison of the human and canine cytokines IL-1(alpha/beta) and TNF-alpha to orthologous other mammalians. J Hered. 2007;98(5):485-90. Epub 2007/06/19. 

Unit Molcular Toxicology, 2007-2010

Rodt T, von Falck C, Halter R, Tillkorn C, Lotz J, Galanski M, Borlak J. Small animal imaging of lung cancer; comparison of different imaging modalities exemplified by SPC-myc and SPC-raf transgenic mouse models. Scientific and Educational Exhibits. Eur Radiol. 2009;19(0):389.

Rodt T, von Falck C, Halter R, Ringe K, Shin HO, Galanski M, Borlak J. In vivo microCT quantification of lung tumor growth in SPC-raf transgenic mice. Front Biosci. 2009;14:1939-44. Epub 2009/03/11.

Rodt T, von Falck C, Halter R, Diensthuber M, Galanski M, Borlak J. Mikro-CT und 3D-Nachverarbeitung des Tracheobronchialsystems der Maus. 39. Kongress der Deutschen Gesellschaft für Endoskopie und Bildgebende Verfahren, München, Germany. Endoskopie heute 2009, 22:65. (Lecture)

Rohrbeck A, Borlak J. Cancer genomics identifies regulatory gene networks associated with the transition from dysplasia to advanced lung adenocarcinomas induced by c-Raf-1. PLoS One. 2009;4(10):e7315. Epub 2009/10/09.

Rohrbeck A, Muller VS, Borlak J. Molecular characterization of lung dysplasia induced by c-Raf-1. PLoS One. 2009;4(5):e5637. Epub 2009/06/17.

von Falck C, Rodt T, Halter R, Spanel R, Galanski M, Borlak J. Combined microPET/CT for imaging of hepatocellular carcinoma in mice. Front Biosci. 2009;14:2193-202. Epub 2009/03/11.

von Falk C, Rodt T, Halter R, Shin H, Galanski M and Borlak J. Die in-vivo microCT-Cholangiographie zur Evaluation des biliären Systems im murinen Tiermodell. 89. Deutscher Röntgenkongress. 5. Gemeinsamer Kongress der DRG und ÖRG, Berlin, Germany. RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren 180, S1, 2008

von Falk C, Halter R, Galanski M and Borlak J. Morphologische und metabolische Phänotypisierung von transgenen Mausmodellen der Hepatokarzinogenese, 45. Jahrestagung der Deutschen Gesellschaft für Nuklearmedizin. Nuklearmedizin - Molecular Imaging and Therapy, 2008;46:49-64 (Abstract V184).

Unit Proliferation Control, 2007-2012

Serres MP, Kossatz U, Chi Y, Roberts JM, Malek NP, Besson A. p27(Kip1) controls cytokinesis via the regulation of citron kinase activation. Journal of Clinical Investigation. 2012;122(3):844-58. Epub 2012/02/02.

Taft F, Harmrolfs K, Nickeleit I, Heutling A, Kiene M, Malek N, Sasse F, Kirschning A. Combined muta- and semisynthesis: a powerful synthetic hybrid approach to access target specific antitumor agents based on ansamitocin P3. Chemistry. 2012;18(3):880-6. Epub 2011/12/16.

Brauckhoff A, Malz M, Tschaharganeh D, Malek N, Weber A, Riener MO, Soll C, Samarin J, Bissinger M, Schmidt J, Longerich T, Ehemann V, Schirmacher P, Breuhahn K. Nuclear expression of the ubiquitin ligase seven in absentia homolog (SIAH)-1 induces proliferation and migration of liver cancer cells. J Hepatol. 2011;55(5):1049-57. Epub 2011/03/02.

Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grunwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gonczy P, Malek NP. The SCF-FBXW5 E3-ubiquitin ligase is regulated by PLK4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol. 2011;13(8):1004-9. Epub 2011/07/05.

Woller N, Knocke S, Mundt B, Gurlevik E, Struver N, Kloos A, Boozari B, Schache P, Manns MP, Malek NP, Sparwasser T, Zender L, Wirth TC, Kubicka S, Kuhnel F. Virus-induced tumor inflammation facilitates effective DC cancer immunotherapy in a Treg-dependent manner in mice. Journal of Clinical Investigation. 2011;121(7):2570-82. Epub 2011/06/08.

Kossatz U, Breuhahn K, Wolf B, Hardtke-Wolenski M, Wilkens L, Steinemann D, Singer S, Brass F, Kubicka S, Schlegelberger B, Schirmacher P, Manns MP, Singer JD, Malek NP. The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells. Journal of Clinical Investigation. 2010;120(11):3820-33. Epub 2010/10/28.

Stauch B, Simon B, Basile T, Schneider G, Malek NP, Kalesse M, Carlomagno T. Elucidation of the structure and intermolecular interactions of a reversible cyclic-peptide inhibitor of the proteasome by NMR spectroscopy and molecular modeling. Angew Chem Int Ed Engl. 2010;49(23):3934-8. Epub 2010/04/22.

Buitrago-Molina LE, Pothiraju D, Lamle J, Marhenke S, Kossatz U, Breuhahn K, Manns MP, Malek N, Vogel A. Rapamycin delays tumor development in murine livers by inhibiting proliferation of hepatocytes with DNA damage. Hepatology. 2009;50(2):500-9. Epub 2009/07/31.

Edukulla R, Woller N, Mundt B, Knocke S, Gurlevik E, Saborowski M, Malek N, Manns MP, Wirth T, Kuhnel F, Kubicka S. Antitumoral immune response by recruitment and expansion of dendritic cells in tumors infected with telomerase-dependent oncolytic viruses. Cancer Res. 2009;69(4):1448-58. Epub 2009/02/05.

Gurlevik E, Woller N, Schache P, Malek NP, Wirth TC, Zender L, Manns MP, Kubicka S, Kuhnel F. p53-dependent antiviral RNA-interference facilitates tumor-selective viral replication. Nucleic Acids Res. 2009;37(12):e84. Epub 2009/05/16.

Nickeleit I, Zender S, Sasse F, Geffers R, Brandes G, Sorensen I, Steinmetz H, Kubicka S, Carlomagno T, Menche D, Gutgemann I, Buer J, Gossler A, Manns MP, Kalesse M, Frank R, Malek NP. Argyrin a reveals a critical role for the tumor suppressor protein p27(kip1) in mediating antitumor activities in response to proteasome inhibition. Cancer Cell. 2008;14(1):23-35. Epub 2008/07/05.

McEvoy JD, Kossatz U, Malek N, Singer JD. Constitutive turnover of cyclin E by Cul3 maintains quiescence. Mol Cell Biol. 2007;27(10):3651-66. Epub 2007/03/07.