Nanoparticles

Research Focus

Project objectives of the Research Unit ‘Nanoparticles’ are advanced method development and its implementation for the fabrication of novel nanomaterials, and the application of these nanomaterials in biomedical science and regenerative nanomedicine, as well as its translation into clinical use.
Applying the techniques of pulsed laser ablation in liquids (PLAL) and in-situ bioconjugation, the RU works on the fabrication of ultrapure mono- and multimaterial nanoparticles in different research directions:

  • Innovative nanodrugs for the directed, cell-selective transport of therapeutics and for controlled ion-, drug-, and gene-delivery purposes.
  • Non-bleaching nanomarker for advanced and specific immunolabeling and high-resolution, real-time bio-imaging.
  • A new class of nanomagnets for efficient recycling of bioactive substances and for controlled cell manipulation and stimulation.
  • Multiparametric nanosensors for the highly sensitive and precise detection and online monitoring of analytes in complex media.
  • Biocompatible nanocomposites for the creation of novel implants with decreased infection rates and self-healing ability for reconstructive therapy.
  • Highly efficient nanocatalysts for the regulation of biocatalytic reactions.
  • The implementation of multifunctional nanomaterials with combined targeting, imaging and therapeutic function as theranostic agents.
  • Risk assessment of nanomaterials and evaluation of biocompatibility and potential cytotoxicity for their approved medical and clinical application.
  • The fabrication of new material-combinations by PLAL with adjustable characteristics.

Collaborations

  • REBIRTH Unit Laser Biofabrication: Material development for tissue engineering.
  • T. Ross, A. Polyak, Department of Nuclear Medicine, Hannover Medical School, Development of nanoparticle-based radiotracers.
  • M. Stiesch, N. Stumpp, Center of Dental, Oral and Maxillofacial Science, Hannover Medical School, Development of nanoparticle-based local drug-delivery systems.
  • L. Sajti, Advanced Implant Solutions, Austrian Institute of Technology GmbH (Austria), Nanomaterial development for innovative implant solutions.
  • M. Heuser, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Labelling, sorting and gene knockdown with nanoparticles in primary hepatocytes.
  • R. Intartaglia, Italian Institute of Technology (Italy), Silicon nanoparticle-based biohybrids for bioimaging.
  • C. Feldmann, Department of Cardiothoracic, Transplantation and Vascular Surgery (HTTG), Hannover Medical School.
  • B. Braun Melsungen AG.
  • IBA Lifesciences GmbH.

Further Research Projects

  • Surface functionalization to prevent and treat LVAD-related infections (Thoratec Corporation, industrial project).
  • Laser-based scaffold development and surface functionalization (VW Stiftung Land Niedersachsen – Biofabrication for NIFE).

Awards

  • 2015:  Poster award to A. Barchanski: Laser-generated nanomaterials for biomedical implants, International Symposium of Biofabrication, Hannover.
  • 2010: Poster award to A. Barchanski: Sperm vitality and blastocyst development after incubation with ligand-free and bioconjugated gold nanoparticles, Nanomed conference, Berlin.
  • 2010: Poster award to A. Barchanski: Impact of spacer length on laser-generated gold nanomarker design, ANGEL conference, Engelberg (Switzerland).

Teaching

Lecture “Principles of materials sciences for regenerative medicine 2”- with seminar entitled “Nanoparticles in medicine” and tutorial on “Nano-manufacturing & nanoanalytics using lasers” in the PhD-Program “Regenerative Sciences” of Hannover Biomedical Research School.

Publications

2013 - ongoing

2017

Jyotsana N, Sharma A, Chaturvedi A, Scherr M, Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Suhs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M. RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia. 2017/08/23 ed2017.

Barshutina MN, Barchanski A. Pulsed Laser Ablation for Obtaining Contrast Agents Based on Dysprosium Oxide (Dy2O3) Nanoparticles. Measurement Techniques. 2017;60(3):216-9.

Polyak A, Naszalyi Nagy L, Mihaly J, Gorres S, Wittneben A, Leiter I, Bankstahl JP, Sajti L, Kellermayer M, Zrinyi M, Ross TL. Preparation and (68)Ga-radiolabeling of porous zirconia nanoparticle platform for PET/CT-imaging guided drug delivery. J Pharm Biomed Anal. 2017;137:146-50. Epub 2017/01/26.

2016

Almansour M, Sajti L, Melhim W, Jarrar BM. Ultrastructural hepatocytic alterations induced by silver nanoparticle toxicity. Ultrastruct Pathol. 2016;40(2):92-100.

Almansour M, Sajti CL, Shraideh Z, Jarrar B. Pulmonary Histological Alterations Induced by 20 nm Silver Nanoparticles. J Nano Res-Sw. 2016;35:104-14.

2015

Almansour M, Sajti L, Melhim W, Jarrar B. Ultrastructural Hepatic Alterations Induced by 35 Nm Zinc Oxide Nanoparticles. Nanoscience and Nanotechnology Letters. 2015;7(9):763-9.

Barchanski A, Funk D, Wittich O, Tegenkamp C, Chichkov BN, Sajti CL. Picosecond Laser Fabrication of Functional Gold–Antibody Nanoconjugates for Biomedical Applications. The Journal of Physical Chemistry C. 2015;119(17):9524-33.

Almansour M, Sajti CL, Shraideh Z, Jarrar B. Pulmonary Histological Alterations Induced by 20 nm Silver Nanoparticles. Journal of Nano Research. 2015;35: 104-114.

Karapetyan A, Reymers A, Giorgio S, Fauquet C, Sajti L, Nitsche S, Nersesyan M, Gevorgyan V, Marine W. Cuprous Oxide Thin Films Prepared by Thermal Oxidation of Copper Layer. Morphological and Optical Properties. Journal of Luminescence. 2015;159:325-32.

Barchanski A, Taylor U, Sajti LC, Gamrad L, Kues AW, Rath D, Barcikowski S. Bioconjugated Gold Nanoparticles Penetrate into Spermatozoa Depending on Plasma Membrane Status. Journal of biomedical nanotechnology. 2015;11(in press).

2014

Pikramenou Z, McCallion C, Carreira S, Dobson P, Brown K, Diaz Fernandez YA, Abdollah M, Zhou D, Sun D, Moise S, Litti L, Yung LL, Borsley S, Dragneva N, Barchanski A, El-Sayed M, Heuer-Jungemann A, Pallares RM, Tsang E, Barry N, Mitchell S, Thanh NTK, Thanou M, Parkin I, Ray P, Jones R. Other Nanoparticles: General Discussion. Faraday Discussions. 2014;175(0):289-303.

Taylor U, Garrels W, Barchanski A, Peterson S, Sajti L, Lucas-Hahn A, Gamrad L, Baulain U, Klein S, Kues WA, Barcikowski S, Rath D. Injection of Ligand-Free Gold and Silver Nanoparticles into Murine Embryos Does Not Impact Pre-Implantation Development. Beilstein Journal of Nanotechnology. 2014;5:677-88.

Taylor U, Barchanski A, Petersen S, Kues WA, Baulain U, Gamrad L, Sajti L, Barcikowski S, Rath D. Gold Nanoparticles Interfere with Sperm Functionality by Membrane Adsorption without Penetration. Nanotoxicology. 2014;8 Suppl 1:118-27. Epub 2013/12/03.

Hess C, Schwenke A, Wagener P, Franzka S, Laszlo Sajti C, Pflaum M, Wiegmann B, Haverich A, Barcikowski S. Dose-Dependent Surface Endothelialization and Biocompatibility of Polyurethane Noble Metal Nanocomposites. J Biomed Mater Res A. 2014;102(6):1909-20. Epub 2013/07/16.

Bergmann C, Schwenke A, Sajti L, Chichkov B, Fischer H. Temperature-Dependent Morphology Changes of Noble Metal Tricalcium Phosphate-Nanocomposites. Ceramics International. 2014;40(6):7931-9.

Barchanski A, Evlyukhin AB, Koroleva A, Reinhardt C, Sajti CL, Zywietz U, Chichkov B. Laser Generation and Printing of Nanoparticles. In: Veiko VP, Konov VI, editors. Fundamentals of Laser-Assisted Micro- and Nanotechnologies: Springer International Publishing; 2014. p. 103-23.

2013

Sowa-Söhle Eveline N, Schwenke A, Wagener P, Weiss A, Wiegel H, Sajti Csaba L, Haverich A, Barcikowski S, Loos A. Antimicrobial Efficacy, Cytotoxicity, and Ion Release of Mixed Metal (Ag, Cu, Zn, Mg) Nanoparticle Polymer Composite Implant Material. BioNanoMaterials2013. p. 217.

Schwenke A, Wagener P, Weiß A, Klimenta K, Wiegel H, Sajti L, Barcikowski S. Laserbasierte Generierung Matrixbinderfreier Nanopartikel-Polymerkomposite Für Bioaktive Medizinprodukte/Laser-Based Generation of Nanocomposites without Matrix-Coupling Agents for Bioactive Medical Devices. Chemie Ingenieur Technik. 2013;85(5):740-6.

Schwenke A, Dalüge H, Kiyan R, Sajti CL, Chichkov B. Non-Agglomerated Gold-Pmma Nanocomposites by in Situ-Stabilized Laser Ablation in Liquid Monomer for Optical Applications. Applied Physics A. 2013;111(2):451-7.

Menéndez-Manjón A, Schwenke A, Steinke T, Meyer M, Giese U, Wagener P, Barcikowski S. Ligand-Free Gold–Silver Nanoparticle Alloy Polymer Composites Generated by Picosecond Laser Ablation in Liquid Monomer. Applied Physics A. 2013;110(2):343-50.

Bagga K, Barchanski A, Intartaglia R, Dante S, Marotta R, Diaspro A, Sajti CL, Brandi F. Laser-Assisted Synthesis of Staphylococcus Aureus Protein-Capped Silicon Quantum Dots as Bio-Functional Nanoprobes. Laser Physics Letters. 2013;10(6):065603.

2006 - 2012

2012

Wagener P, Schwenke A, Barcikowski S. How Citrate Ligands Affect Nanoparticle Adsorption to Microparticle Supports. Langmuir. 2012;28(14):6132-40.

Taylor U, Barchanski A, Garrels W, Klein S, Kues W, Barcikowski S, Rath D. Toxicity of Gold Nanoparticles on Somatic and Reproductive Cells. In: Zahavy E, Ordentlich A, Yitzhaki S, Shafferman A, editors. Nano-Biotechnology for Biomedical and Diagnostic Research: Springer Netherlands; 2012. p. 125-33.

Intartaglia R, Barchanski A, Bagga K, Genovese A, Das G, Wagener P, Di Fabrizio E, Diaspro A, Brandi F, Barcikowski S. Bioconjugated Silicon Quantum Dots from One-Step Green Synthesis. Nanoscale. 2012;4(4):1271-4.

Hahn A, Fuhlrott J, Loos A, Barcikowski S. Cytotoxicity and Ion Release of Alloy Nanoparticles. J Nanopart Res. 2012;14(1):1-10.

Grade S, Eberhard J, Wagener P, Winkel A, Sajti CL, Barcikowski S, Stiesch M. Therapeutic Window of Ligand-Free Silver Nanoparticles in Agar-Embedded and Colloidal State: In Vitro Bactericidal Effects and Cytotoxicity. Advanced Engineering Materials. 2012;14(5):B231-B9.

Evlyukhin AB, Novikov SM, Zywietz U, Eriksen RL, Reinhardt C, Bozhevolnyi SI, Chichkov BN. Demonstration of Magnetic Dipole Resonances of Dielectric Nanospheres in the Visible Region. Nano Lett. 2012;12(7):3749-55.

Barchanski A, Hashimoto N, Petersen S, Sajti CL, Barcikowski S. Impact of Spacer and Strand Length on Oligonucleotide Conjugation to the Surface of Ligand-Free Laser-Generated Gold Nanoparticles. Bioconjug Chem. 2012;23(5):908-15.

2011

Wagener P, Faramarzi S, Schwenke A, Rosenfeld R, Barcikowski S. Photoluminescent Zinc Oxide Polymer Nanocomposites Fabricated Using Picosecond Laser Ablation in an Organic Solvent. Applied Surface Science. 2011;257(16):7231-7.

Wagener P, Brandes G, Schwenke A, Barcikowski S. Impact of in Situ Polymer Coating on Particle Dispersion into Solid Laser-Generated Nanocomposites. Phys Chem Chem Phys. 2011;13(11):5120-6.

Schwenke A, Wagener P, Nolte S, Barcikowski S. Influence of Processing Time on Nanoparticle Generation During Picosecond-Pulsed Fundamental and Second Harmonic Laser Ablation of Metals in Tetrahydrofuran. 2011;104(1):77-82.

Sajti CL, Barchanski A, Wagener P, Klein S, Barcikowski S. Delay Time and Concentration Effects During Bioconjugation of Nanosecond Laser-Generated Nanoparticles in a Liquid Flow. The Journal of Physical Chemistry C. 2011;115(12):5094-101.

Petersen S, Barchanski A, Taylor U, Klein S, Rath D, Barcikowski S. Penetratin-Conjugated Gold Nanoparticles − Design of Cell-Penetrating Nanomarkers by Femtosecond Laser Ablation. The Journal of Physical Chemistry C. 2011;115(12):5152-9.

Menéndez-Manjón A, Wagener P, Barcikowski S. Transfer-Matrix Method for Efficient Ablation by Pulsed Laser Ablation and Nanoparticle Generation in Liquids. The Journal of Physical Chemistry C. 2011;115(12):5108-14.

Menéndez-Manjón A, Barcikowski S. Hydrodynamic Size Distribution of Gold Nanoparticles Controlled by Repetition Rate During Pulsed Laser Ablation in Water. Applied Surface Science. 2011;257(9):4285-90.

Jakobi J, Menendez-Manjon A, Chakravadhanula VS, Kienle L, Wagener P, Barcikowski S. Stoichiometry of Alloy Nanoparticles from Laser Ablation of Ptir in Acetone and Their Electrophoretic Deposition on Ptir Electrodes. Nanotechnology. 2011;22(14):145601.

Hahn A, Gunther S, Wagener P, Barcikowski S. Electrochemistry-Controlled Metal Ion Release from Silicone Elastomer Nanocomposites through Combination of Different Metal Nanoparticles. Journal of Materials Chemistry. 2011;21(28):10287-9.

Hahn A, Brandes G, Wagener P, Barcikowski S. Metal Ion Release Kinetics from Nanoparticle Silicone Composites. J Control Release. 2011;154(2):164-70.

Duran MC, Willenbrock S, Barchanski A, Muller JM, Maiolini A, Soller JT, Barcikowski S, Nolte I, Feige K, Murua Escobar H. Comparison of Nanoparticle-Mediated Transfection Methods for DNA Expression Plasmids: Efficiency and Cytotoxicity. J Nanobiotechnology. 2011;9:47. Epub 2011/10/22.

Barchanski A, Taylor U, Klein S, Petersen S, Rath D, Barcikowski S. Golden Perspective: Application of Laser-Generated Gold Nanoparticle Conjugates in Reproductive Biology. Reprod Domest Anim. 2011;46 Suppl 3:42-52.

2010

Walter JG, Petersen S, Stahl F, Scheper T, Barcikowski S. Laser Ablation-Based One-Step Generation and Bio-Functionalization of Gold Nanoparticles Conjugated with Aptamers. J Nanobiotechnology. 2010;8:21.

Taylor U, Klein S, Petersen S, Kues W, Barcikowski S, Rath D. Nonendosomal Cellular Uptake of Ligand-Free, Positively Charged Gold Nanoparticles. Cytometry A. 2010;77(5):439-46.

Sajti C, Petersen S, Menéndez-Manjón A, Barcikowski S. In-Situ Bioconjugation in Stationary Media and in Liquid Flow By femtosecond Laser Ablation. Applied Physics A. 2010;101(2):259-64.

Menéndez-Manjón A, Chichkov BN, Barcikowski S. Influence of Water Temperature on the Hydrodynamic Diameter of Gold Nanoparticles from Laser Ablation. The Journal of Physical Chemistry C. 2010;114(6):2499-504.

Menendez-Manjon A, Barcikowski S, Shafeev AG, Mazhukin IV, Chichkov NB. Influence of Beam Intensity Profile on the Aerodynamic Particle Size Distributions Generated by Femtosecond Laser Ablation. 2010;28(1):45-52.

Klein S, Petersen S, Taylor U, Rath D, Barcikowski S. Quantitative Visualization of Colloidal and Intracellular Gold Nanoparticles by Confocal Microscopy. J Biomed Opt. 2010;15(3):036015.

Jakobi J, Petersen S, Menendez-Manjon A, Wagener P, Barcikowski S. Magnetic Alloy Nanoparticles from Laser Ablation in Cyclopentanone and Their Embedding into a Photoresist. Langmuir. 2010;26(10):6892-7. Epub 2010/04/17.

Hahn A, Stöver T, Paasche G, Löbler M, Sternberg K, Rohm H, Barcikowski S. Therapeutic Window for Bioactive Nanocomposites Fabricated by Laser Ablation in Polymer-Doped Organic Liquids. Advanced Engineering Materials. 2010;12(5):B156-B62.

Barcikowski S, Hahn A, Guggenheim M, Reimers K, Ostendorf A. Biocompatibility of Nanoactuators: Stem Cell Growth on Laser-Generated Nickel–Titanium Shape Memory Alloy Nanoparticles. Journal of Nanoparticle Research. 2010;12(5):1733-42.

Barchanski A, Sajti LC, Sehring C, Petersen S, Barcikowski S. Design of Bi-Functional Bioconjugated Gold Nanoparticles by Pulsed Laser Ablation with Minimized Degradation. 2010.

2009

Petersen S, Soller JT, Wagner S, Richter A, Bullerdiek J, Nolte I, Barcikowski S, Murua Escobar H. Co-Transfection of Plasmid DNA and Laser-Generated Gold Nanoparticles Does Not Disturb the Bioactivity of Gfp-Hmgb1 Fusion Protein. J Nanobiotechnology. 2009;7:6.

Petersen S, Jakobi J, Barcikowski S. In Situ Bioconjugation—Novel Laser Based Approach to Pure Nanoparticle-Conjugates. Applied Surface Science. 2009;255(10):5435-8.

Petersen S, Barcikowski S. In-Situ Bioconjugation - Single Step Approach to Tailored Nanoparticle-Bioconjugates by Ultrashort Pulsed Laser Ablation. 2009;19(8):1167-72.

Petersen S, Barcikowski S. Conjugation Efficiency of Laser-Based Bioconjugation of Gold Nanoparticles with Nucleic Acids. The Journal of Physical Chemistry C. 2009;113(46):19830-5.

Menendez-Manjon A, Jakobi J, Schwabe K, Krauss KJ, Barcikowski S. Mobility of Nanoparticles Generated by Femtosecond Laser Ablation in Liquids and Its Application to Surface Patterning. 2009;4(2):95-9.

Hahn A, Barcikowski S. Production of Bioactive Nanomaterial Using Laser Generated Nanoparticles. 2009;4(1):51-4.

Barsch N, Jakobi J, Weiler S, Barcikowski S. Pure Colloidal Metal and Ceramic Nanoparticles from High-Power Picosecond Laser Ablation in Water and Acetone. Nanotechnology. 2009;20(44):445603.

Bärsch N, Gatti A, Barcikowski S. Improving Laser Ablation of Zirconia by Liquid Films: Multiple Influences of Liquids on Surface Machining and Nanoparticle Generation. 2009;4(1):66-70.

Barcikowski S, Walter J, Hahn A, Koch J, Haloui H, Herrmann T, Gatti A. Picosecond and Femtosecond Laser Machining May Cause Health Risks Related to Nanoparticle Emission. 2009;4(3):159-64.

Barcikowski S, Devesa F, Moldenhauer K. Impact and Structure of Literature on Nanoparticle Generation by Laser Ablation in Liquids. Journal of Nanoparticle Research. 2009;11(8):1883-93.

Petersen S, Jakobi J, Hörtinger A, Barcikowski S. In-Situ Conjugation - Tailored Nanoparticle-Conjugates by Laser Ablation in Liquids. J Laser Micro Nanoen. 2009;4(1):71-4.

2008

Baersch N, Barcikowski S, Baier K. Ultrafast-Laser-Processed Zirconia and Its Adhesion to Dental Cement. 2008;3(2):78-83.

Hahn A, Barcikowski S, Chichkov BN. Influences on Nanoparticle Production during Pulsed Laser Ablation. J Laser Micro Nanoen. 2008;3(2):73-7.

vSattari R, Dieling C, Barcikowski S, Chichkov B. Laser-based Fragmentation of Microparticles for Nanoparticle Generation. J Laser Micro Nanoen. 2008;3(2):100-5.

2007

Sartinska LL, Barchikovski S, Wagenda N, Rud’ BM, Timofeeva II. Laser Induced Modification of Surface Structures. Applied Surface Science. 2007;253(9):4295-9.

Barcikowski S, Menéndez-Manjón A, Chichkov B, Brikas M, Račiukaitis G. Generation of Nanoparticle Colloids by Picosecond and Femtosecond Laser Ablations in Liquid Flow. Applied Physics Letters. 2007;91(8):083113.

Barcikowski S, Hahn A, Kabashin AV, Chichkov BN. Properties of Nanoparticles Generated During Femtosecond Laser Machining in Air and Water. Applied Physics A. 2007;87(1):47-55.

Barcikowski S, Hahn A, Chichkov BN. Nanoparticles as Potential Risk During Femtosecond Laser Ablation. Journal of Laser Applications. 2007;19(2):65-73.

Hahn A, Barcikowski S, Ostendorf A. The nanoparticle risk during pulsed laser ablation. The Laser User Magazine. 2007, 47, 32-33.

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