Functional and Molecular MRI

Objectives

Our Long term goals are:

  1. Establishment of a non-invasive and radiation exposure free imaging platform for translational imaging that utilizes morphologic and functional imaging to monitor regenerative therapies from bench to bedside
  2. Monitoring transplants and treatment using MRI
  3. Applying inflammation imaging cell tracking techniques using MRI
  4. Development of advanced algorithms for post-processing of imaging data
  5. For the general public the transition from methods using ionizing radiation (such as CT, x-ray) to MRI reduces man-made radiation exposure thus adding great value to the society

Milestones: 

  • In vivo monitoring of bioimplants and transplants using MRI techniques determining morphology, organ function, perfusion and tissue characterization
  • Characterization of stability, functional properties and potential problems of regenerative tissue grafts with MRI in large animal models and humans
  • Establishment of multimodal imaging (functional MRI & PET & optical imaging)
  • Implementation of new MRI techniques with alternate signal sources such as 19F or hyperpolarized Xenon
  • Establishment of functional MRI of the lung and lung transplants using an Organ Care System
  • Establishment of functional MRI of various organs using an Organ Care System
  • Establishment of functional MRI of the heart and the liver in mice and transfer new techniques to large animals and humans

Research Focus

Based on recent advances in imaging technologies new imaging strategies were developed to evaluate morphology, function, and molecular characteristics of various organs and cells/cell cluster. The overall goal of Core Imaging Radiology is to provide a translational imaging platform for morphologic and functional imaging to guide regenerative therapies such as bioimplants, cellular transplants, and engineered tissues. Magnetic Resonance Imaging (MRI) in particular offers a wide range of new functional techniques to quantify and monitor physiologic and pathologic processes such as perfusion, wall motion, vascular and valvular flow, distensibility, edema, fibrosis, tissue diffusivity and oxygenation, and metabolites. Due to the lack of ionizing radiation, MRI is well suited to monitor the transition from bench to bedside in regenerative therapies. We offer a wide range of MR imaging technologies to facilitate this transition in a safe and controlled fashion. 

Collaborations

  • Department of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Prof. Dr. med. A. Haverich
  • Institute of Toxicology and Experimental Medicine (ITEM), Hannover
  • Department of Nephrology, Hannover Medical School, Prof. Dr. med. H. Haller
  • Department of Experimental Physics 5, University of Würzburg, Germany (Prof. Jakob) 
  • Johns Hopkins University, Baltimore, MD, USA (Prof. Lewin)
  • NIH/University of Wisconsin, USA, Prof. Bluemke
  • Columbia University, New York, USA, Prof. Barr
  • University of Sheffield, UK, Prof. Wild
  • Siemens Advanced Therapy, Forchheim, Germany
  • OvG University of Magdeburg, Prof. Rose
  • OvG University of Magdeburg, Prof. Speck
  • Twincore, Hannover/Braunschweig, Prof. Kalinke
  • Fraunhofer MEVIS, Bremen, Germany

Patents

  • Shin „Generating model data representing a biological body section”, US 20120035888 A1.
  • Voskrebenzev, Gutberlet, Vogel-Claussen „Method of quantitative magnetic resonance lung imaging“ Nr. EP15001782

Publications

2013 - ongoing

2017

Ruppert J, Hartung D, Westhoff-Bleck M, Herrmann J, Stubbs B, Cordes J, Kruger THC, Lichtinghagen R, Kahl KG. Increased pericardial adipose tissue and cardiometabolic risk in patients with schizophrenia versus healthy controls. Eur Arch Psychiatry Clin Neurosci. 2017/11/25 ed2017.

Kaireit TF, Gutberlet M, Voskrebenzev A, Freise J, Welte T, Hohlfeld JM, Wacker F, Vogel-Claussen J. Comparison of quantitative regional ventilation-weighted fourier decomposition MRI with dynamic fluorinated gas washout MRI and lung function testing in COPD patients. J Magn Reson Imaging. 2017/11/22 ed2017.

Getzin T, May M, Schmidbauer M, Gutberlet M, Martirosian P, Oertel R, Wacker F, Schindler C, Hueper K. Usability of Functional MRI in Clinical Studies for Fast and Reliable Assessment of Renal Perfusion and Quantification of Hemodynamic Effects on the Kidney. J Clin Pharmacol. 2017/11/11 ed2017.

Gutberlet M, Kaireit TF, Voskrebenzev A, Lasch F, Freise J, Welte T, Wacker F, Hohlfeld JM, Vogel-Claussen J. Free-breathing Dynamic (19)F Gas MR Imaging for Mapping of Regional Lung Ventilation in Patients with COPD. Radiology. 2017/10/04 ed2017. p. 170591.

Barkhausen J, Kahn T, Krombach GA, Kuhl CK, Lotz J, Maintz D, Ricke J, Schonberg SO, Vogl TJ, Wacker FK, German Association of Chairmen in Academic R. White Paper: Interventional MRI: Current Status and Potential for Development Considering Economic Perspectives, Part 2: Liver and Other Applications in Oncology. Rofo. 2017/09/02 ed2017. p. 1047-54.

Voskrebenzev A, Gutberlet M, Klimes F, Kaireit TF, Schonfeld C, Rotarmel A, Wacker F, Vogel-Claussen J. Feasibility of quantitative regional ventilation and perfusion mapping with phase-resolved functional lung (PREFUL) MRI in healthy volunteers and COPD, CTEPH, and CF patients. Magn Reson Med. 2017/09/01 ed2017.

Peperhove M, Vo Chieu VD, Jang MS, Gutberlet M, Hartung D, Tewes S, Warnecke G, Fegbeutel C, Haverich A, Gwinner W, Lehner F, Brasen JH, Haller H, Wacker F, Gueler F, Hueper K. Assessment of acute kidney injury with T1 mapping MRI following solid organ transplantation. Eur Radiol. 2017/07/16 ed2018. p. 44-50.

Dettmer S, Shin HO, Vogel-Claussen J, Westphal M, Haverich A, Warnecke G, Welte T, Wacker F, Gottlieb J, Suhling H. CT at onset of chronic lung allograft dysfunction in lung transplant patients predicts development of the restrictive phenotype and survival. Eur J Radiol. 2017/06/26 ed2017. p. 78-84.

Derlin T, Gueler F, Brasen JH, Schmitz J, Hartung D, Herrmann TR, Ross TL, Wacker F, Wester HJ, Hiss M, Haller H, Bengel FM, Hueper K. Integrating MRI and Chemokine Receptor CXCR4-Targeted PET for Detection of Leukocyte Infiltration in Complicated Urinary Tract Infections After Kidney Transplantation. J Nucl Med. 2017/04/30 ed2017. p. 1831-7.

Czerner CP, Winther HB, Zapf A, Wacker F, Vogel-Claussen J. Breath-hold and free-breathing 2D phase-contrast MRI for quantification of oxygen-induced changes of pulmonary circulation dynamics in healthy volunteers. J Magn Reson Imaging. 2017/04/07 ed2017. p. 1698-706.

Hueper K, Schmidbauer M, Thorenz A, Brasen JH, Gutberlet M, Mengel M, Hartung D, Chen R, Meier M, Haller H, Wacker F, Rong S, Gueler F. Longitudinal evaluation of perfusion changes in acute and chronic renal allograft rejection using arterial spin labeling in translational mouse models. J Magn Reson Imaging. 2017/03/28 ed2017. p. 1664-72.

Dettmer S, Grunwald V, Fuehner T, Ganser A, Wacker F, Ivanyi P, Rodt T. CT patterns of organizing pneumonia in patients treated with VEGF/mTOR inhibitors for metastatic renal cell cancer: an observational study. Acta Radiol Open. 2017/03/23 ed2017. p. 2058460117694216.

Tewes S, Gueler F, Chen R, Gutberlet M, Jang MS, Meier M, Mengel M, Hartung D, Wacker F, Rong S, Hueper K. Functional MRI for characterization of renal perfusion impairment and edema formation due to acute kidney injury in different mouse strains. PLoS One. 2017/03/21 ed2017. p. e0173248.

Kahl KG, Utanir F, Schweiger U, Kruger TH, Frieling H, Bleich S, Gutberlet M, Hartung D. Reduced muscle mass in middle-aged depressed patients is associated with male gender and chronicity. Prog Neuropsychopharmacol Biol Psychiatry. 2017/01/31 ed2017. p. 58-64.

2016

Tewes S, Mokov N, Hartung D, Schick V, Peters I, Schedl P, Pertschy S, Wacker F, Voshage G, Hueper K. Standardized Reporting of Prostate MRI: Comparison of the Prostate Imaging Reporting and Data System (PI-RADS) Version 1 and Version 2. PLoS One 2016;11(9):e0162879

Schlett CL1, Hendel T, Hirsch J, Weckbach S, Caspers S, Schulz-Menger J, Ittermann T, von Knobelsdorff-Brenkenhoff F, Ladd SC, Moebus S, Stroszczynski C, Fischer B, Leitzmann M, Kuhl C, Pessler F, Hartung D, Kemmling Y, Hetterich H, Amunts K, Günther M, Wacker F, Rummeny E, Kauczor HU, Forsting M, Völzke H, Hosten N, Reiser MF, Bamberg F. Quantitative, Organ-Specific Interscanner and Intrascanner Variability for 3 T Whole-Body Magnetic Resonance Imaging in a Multicenter, Multivendor Study. Invest Radiol. 2016 Apr;51(4):255-65.

Kahl KG, Kerling A, Tegtbur U, Gützlaff E, Herrmann J, Borchert L, Ates Z, Westhoff-Bleck M, Hueper K, Hartung D. Effects of additional exercise training on epicardial, intra-abdominal and subcutaneous adipose tissue in major depressive disorder: A randomized pilot study. Journal of Affective Disorders192 (2016)91–97.

Kahl KG, Herrmann J, Stubbs B, Kruger TH, Cordes J, Deuschle M, Schweiger U, Huper K, Helm S, Birkenstock A, Hartung D. Pericardial adipose tissue and the metabolic syndrome is increased in patients with chronic major depressive disorder compared to acute depression and controls. Prog Neuropsychopharmacol Biol Psychiatry. 2016/08/17 ed2017. p. 30-5.

Voskrebenzev A, Gutberlet M, Kaireit TF, Wacker F, Vogel-Claussen J. Low-pass imaging of dynamic acquisitions (LIDA) with a group-oriented registration (GOREG) for proton MR imaging of lung ventilation. Magn Reson Med. 2016.

Tudorache I, Theodoridis K, Baraki H, Sarikouch S, Bara C, Meyer T, Hoffler K, Hartung D, Hilfiker A, Haverich A, Cebotari S. Decellularized aortic allografts versus pulmonary autografts for aortic valve replacement in the growing sheep model: haemodynamic and morphological results at 20 months after implantation. European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 2016;49(4):1228-38.

Hueper K, Khalifa AA, Brasen JH, Vo Chieu VD, Gutberlet M, Wintterle S, Lehner F, Richter N, Peperhove M, Tewes S, Weber K, Haller H, Wacker F, Gwinner W, Gueler F, Hartung D. Diffusion-Weighted imaging and diffusion tensor imaging detect delayed graft function and correlate with allograft fibrosis in patients early after kidney transplantation. J Magn Reson Imaging. 2016;44(1):112-21.

Hueper K, Gutberlet M, Brasen JH, Jang MS, Thorenz A, Chen R, Hertel B, Barrmeyer A, Schmidbauer M, Meier M, von Vietinghoff S, Khalifa A, Hartung D, Haller H, Wacker F, Rong S, Gueler F. Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice. PloS one. 2016;11(9):e0162705.

2015

Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Li W, Jang MS, Mengel M, Wacker F, Rong S, Gueler F. Kidney Transplantation: Multiparametric Functional Magnetic Resonance Imaging for Assessment of Renal Allograft Pathophysiology in Mice. Invest Radiol 2016;51: 58–65.

Kahl KG, Pars K, Schweiger U, Kunikowska A, Deuschle M, Gutberlet M, Lichtinghagen R, Hueper K, Hartung D. Adrenal gland volume, intra-abdominal and pericardial adipose tissue in major depressive disorder. Psychoneuroendocrinology. 2015 Aug;58:1-8.

Kerling A, Tegtbur U, Gützlaff E, Kück M, Borchert L, Ates Z, von Bohlen A, Frieling H, Hüper K, Hartung D, Schweiger U, Kahl KG. Effects of adjunctive exercise on physiological and psychological parameters in depression: a randomized pilot trial. J Affect Disord. 2015;177:1-6.

Tewes S*, Hueper K*, Hartung D, Imkamp F, Herrmann TRW, Weidemann J, Renckly S, Kuczyk MA, Wacker F, Peters I. Targeted MRI/TRUS fusion guided biopsy in men with previous prostate biopsies using a novel registration software and multiparametric MRI PI-RADS scores: first results. World J Urol. 2015 Nov;33(11):1707-14. *contributed equally

Renne J, Lauermann P, Hinrichs J, Schonfeld C, Sorrentino S, Gutberlet M, Jakob P, Wacker F, Vogel-Claussen J. Clinical Use of Oxygen-Enhanced T1 Mapping Mri of the Lung: Reproducibility and Impact of Closed Versus Loose Fit Oxygen Delivery System. J Magn Reson Imaging. 2015;41(1):60-6. Epub 2013/12/18.

Renne J, Hinrichs J, Schonfeld C, Gutberlet M, Winkler C, Faulenbach C, Jakob P, Schaumann F, Krug N, Wacker F, Hohlfeld JM, Vogel-Claussen J. Noninvasive Quantification of Airway Inflammation Following Segmental Allergen Challenge with Functional Mr Imaging: A Proof of Concept Study. Radiology. 2015;274(1):267-75.

Schonfeld C, Cebotari S, Voskrebenzev A, Gutberlet M, Hinrichs J, Renne J, Hoeper MM, Olsson KM, Welte T, Wacker F, Vogel-Claussen J. Performance of Perfusion-Weighted Fourier Decomposition Mri for Detection of Chronic Pulmonary Emboli. J Magn Reson Imaging. 2015;42(1):72-9.

Hueper K, Gueler F, Brasen JH, Gutberlet M, Jang MS, Lehner F, Richter N, Hanke N, Peperhove M, Martirosian P, Tewes S, Vo Chieu VD, Grosshennig A, Haller H, Wacker F, Gwinner W, Hartung D. Functional Mri Detects Perfusion Impairment in Renal Allografts with Delayed Graft Function. Am J Physiol Renal Physiol. 2015;308(12):F1444-51.

Hueper K, Hensen B, Gutberlet M, Chen R, Hartung D, Barrmeyer A, Meier M, Li W, Jang MS, Mengel M, Wacker F, Rong S, Gueler F. Kidney Transplantation: Multiparametric Functional Magnetic Resonance Imaging for Assessment of Renal Allograft Pathophysiology in Mice. Invest Radiol. 2015.

Renne J, Lauermann P, Hinrichs JB, Schonfeld C, Sorrentino S, Gutberlet M, Jakob P, Haverich A, Warnecke G, Welte T, Wacker FK, Gottlieb J, Vogel-Claussen J. Chronic Lung Allograft Dysfunction: Oxygen-Enhanced T1-Mapping Mr Imaging of the Lung. Radiology. 2015;276(1):266-73.

Solyanik O, Hollmann P, Dettmer S, Kaireit T, Schaefer-Prokop C, Wacker F, Vogel-Claussen J, Shin HO. Quantification of Pathologic Air Trapping in Lung Transplant Patients Using Ct Density Mapping: Comparison with Other Ct Air Trapping Measures. PLoS One. 2015;10(10):e0139102. Epub 2015/10/03.

2014

Ringe KI, Hartung D, von Falck C, Wacker F, Raatschen HJ. 3D-MRCP for evaluation of intra- and extrahepatic bile ducts: comparison of different acquisition and reconstruction planes. BMC Med Imaging. 2014 May 19;14:16.

Kahl KG, Hueper K, Gutberlet M, Detlef AM, Weiss C, von Bohlen A, Schweiger U, Pul R, Lichtinghagen R, Wacker F, Hartung D. Pericardial, intra-abdominal and subdutaneous adipose tissue in patients with major depressive disorder. Acta Psychiat Scand 2014;130(2):137-43.

Hinrichs JB, Renne J, Schoenfeld C, Gutberlet M, Haverich A, Warnecke G, Welte T, Wacker F, Gottlieb J, Vogel-Claussen J. Cardiac Mass and Function Decrease in Bronchiolitis Obliterans Syndrome after Lung Transplantation: Relationship to Physical Activity? PLoS One. 2014;9(12):e114001.

Hueper K, Gutberlet M, Rong S, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. Acute Kidney Injury: Arterial Spin Labeling to Monitor Renal Perfusion Impairment in Mice-Comparison with Histopathologic Results and Renal Function. Radiology. 2014;270(1):117-24.

Dettmer S, Peters L, de Wall C, Schaefer-Prokop C, Schmidt M, Warnecke G, Gottlieb J, Wacker F, Shin HO. Bronchial Wall Measurements in Patients after Lung Transplantation: Evaluation of the Diagnostic Value for the Diagnosis of Bronchiolitis Obliterans Syndrome. PLoS One. 2014;9(4):e93783.

Bauer M, Schilling T, Weidling M, Hartung D, Biskup C, Wriggers P, Wacker F, Bach FW, Haverich A, Hassel T. Geometric Adaption of Biodegradable Magnesium Alloy Scaffolds to Stabilise Biological Myocardial Grafts. Part I. J Mater Sci Mater Med. 2014;25(3):909-16.

Shehata ML, Basha TA, Hayeri MR, Hartung D, Teytelboym OM, Vogel-Claussen J. Mr Myocardial Perfusion Imaging: Insights on Techniques, Analysis, Interpretation, and Findings. Radiographics. 2014;34(6):1636-57.

Hinrichs J, Schaumann F, Renne J, Schonfeld C, Faulenbach C, Winkler C, Gutberlet M, Krug N, Wacker F, Hohlfeld JM, Vogel-Claussen J. Phase-Contrast Mri for Detection of Mild Systemic Hemodynamic Response after Segmental Allergen Challenge in Asthmatic Patients. Acad Radiol. 2014;21(8):994-1001. Epub 2014/07/16.

Vogel-Claussen J, Renne J, Hinrichs J, Schonfeld C, Gutberlet M, Schaumann F, Winkler C, Faulenbach C, Krug N, Wacker FK, Hohlfeld JM. Quantification of Pulmonary Inflammation after Segmental Allergen Challenge Using Turbo-Inversion Recovery-Magnitude Magnetic Resonance Imaging. Am J Respir Crit Care Med. 2014;189(6):650-7.

Hueper K, Peperhove M, Rong S, Gerstenberg J, Mengel M, Meier M, Gutberlet M, Tewes S, Barrmeyer A, Chen R, Haller H, Wacker F, Hartung D, Gueler F. T1-Mapping for Assessment of Ischemia-Induced Acute Kidney Injury and Prediction of Chronic Kidney Disease in Mice. Eur Radiol. 2014;24(9):2252-60.

2013

Hueper K, Hartung D, Gutberlet M, Gueler F, Sann H, Husen B, Wacker F, Reiche D. Assessment of Impaired Vascular Reactivity in a Rat Model of Diabetic Nephropathy: Effect of Nitric Oxide Synthesis Inhibition on Intrarenal Diffusion and Oxygenation Measured by Magnetic Resonance Imaging. Am J Physiol Renal Physiol. 2013;305(10):F1428-35.

Tudorache I, Calistru A, Baraki H, Meyer T, Hoffler K, Sarikouch S, Bara C, Gorler A, Hartung D, Hilfiker A, Haverich A, Cebotari S. Orthotopic Replacement of Aortic Heart Valves with Tissue-Engineered Grafts. Tissue Eng Part A. 2013;19(15-16):1686-94.

Hueper K, Parikh M, Prince MR, Schoenfeld C, Liu C, Bluemke DA, Dashnaw SM, Goldstein TA, Hoffman E, Lima JA, Skrok J, Zheng J, Barr RG, Vogel-Claussen J. Quantitative and Semi-Quantitative Measures of Regional Pulmonary Parenchymal Perfusion by Magnetic Resonance Imaging and Their Relationships to Global Lung Perfusion and Lung Diffusing Capacity – the Mesa Copd Study. Investigative radiology. 2013;48(4):223-30.

Hueper K, Rong S, Gutberlet M, Hartung D, Mengel M, Lu X, Haller H, Wacker F, Meier M, Gueler F. T2 Relaxation Time and Apparent Diffusion Coefficient for Noninvasive Assessment of Renal Pathology after Acute Kidney Injury in Mice: Comparison with Histopathology. Invest Radiol. 2013;48(12):834-42.

Kedziorek DA, Solaiyappan M, Walczak P, Ehtiati T, Fu Y, Bulte JWM, Shea SM, Brost A, Wacker FK, Kraitchman DL. Using C-Arm X-Ray Imaging to Guide Local Reporter Probe Delivery for Tracking Stem Cell Engraftment. Theranostics. 2013;3(11):916-26.

2006 - 2012

2012

Dettmer S, Entrup J, Schmidt M, de Wall C, Wacker F, Shin H. Bronchial Wall Thickness Measurement in Computed Tomography: Effect of Intravenous Contrast Agent and Reconstruction Kernel. Eur J Radiol. 2012;81(11):3606-13.

Bauer M, Hassel T, Biskup C, Hartung D, Schilling T, Weidling M, Wriggers P, Wacker F, Bach Fr W, Haverich A. Geometric Adaption of Resorbable Myocardial Stabilizing Structures Based on the Magnesium Alloys La63 and Zek100 for the Support of Myocardial Grafts on the Left Ventricle. Biomedical Engineering / Biomedizinische Technik2012. p. 22.

Hueper K, Hartung D, Gutberlet M, Gueler F, Sann H, Husen B, Wacker F, Reiche D. Magnetic Resonance Diffusion Tensor Imaging for Evaluation of Histopathological Changes in a Rat Model of Diabetic Nephropathy. Invest Radiol. 2012;47(7):430-7. Epub 2012/06/05.

Hueper K, Zapf A, Skrok J, Pinheiro AC, Goldstein TA, Zheng J, Zimmerman SL, Kamel IR, Abraham MR, Wacker F, Bluemke DA, Abraham T, Vogel-Claussen J. Reduction of Relative Resting Myocardial Blood Flow Is Related to Myocardial Delayed Enhancement, T2-Signal Abnormalities, Left-Ventricular Wall Thickness and Age in Patients with Hypertrophic Cardiomyopathy. Journal of Cardiovascular Magnetic Resonance. 2012;14(Suppl 1):P158-P.

2011

Hueper K, Gutberlet M, Rodt T, Gwinner W, Lehner F, Wacker F, Galanski M, Hartung D. Diffusion Tensor Imaging and Tractography for Assessment of Renal Allograft Dysfunction-Initial Results. Eur Radiol. 2011;21(11):2427-33.

2009

Haider N*, Hartung D*, Fujimoto S*, Petrov A, Kolodgie FD, Virmani R, Ohshima S, Liu H, Zhou J, Fujimoto A, Tahara A, Hofstra L, Narula N, Reutelingsperger C, Narula J. Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: molecular imaging facilitates understanding of pathogenesis. J Nucl Cardiol. 2009 Sep-Oct;16(5):753-62. Epub 2009 Aug 7. *contributed equally

Hartung, D, Thiele, L, Hartung, WM. Atriale Signalwahrnehmung mit wandständigen Elektroden und Floatingelektroden bei identischen Belastungen. Herzschr. Elektrophys. (2009) 20: 39.

2008

Fujimoto S, Hartung D, Ohshima S, Edwards DS, Zhou J, Yalamanchili P, Azure M, Fujimoto A, Isobe S, Matsumoto Y, Boersma H, Wong N, Yamazaki J, Narula N, Petrov A, Narula J. Molecular imaging of matrix metalloproteinase in atherosclerotic lesions. Resolution with dietary modification and statin therapy. J Am Coll Cardiol. 2008, Dec 2;52(23):1847-57.

2007

Hartung D, Schafers M, Fujimoto S, Levkau B, Narula N, Kopka K, Virmani R, Reutelingsperger C, Hofstra L, Kolodgie FD, Petrov A, Narula J. Targeting of matrix metalloproteinase activation for noninvasive detection of vulnerable atherosclerotic lesions. Eur J Nucl Med Mol Imaging. 2007; 34, Suppl 1:S1-8.

Sarai M*, Hartung D*, Petrov A, Zhou J, Narula N, Hofstra L, Kolodgie F, Isobe S, Fujimoto S, Vanderheyden J-L, Virmani R, Reutelingsperger C, Wong ND, Gupta S, Narula J. Broad and Specific Caspase Inhibitor-Induced Acute Repression of Apoptosis in Atherosclerotic Lesions Evaluated by Radiolabeled Annexin A5 Imaging. J Am Coll Cardiol. 2007; 50:2305–12. *contributed equally

Hartung D, Petrov A, Haider N, Fujimoto S, Blankenberg F, Fujimoto A, Virmani R, Kolodgie FD, Strauss HW, Narula J. Radiolabeled Monocyte Chemotactic Protein 1 for the Detection of Inflammation in Experimental Atherosclerosis. J Nucl Med. 2007; 48:1816–1821.

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