Pathology of Humanized Animal Models - Human Pathology

Objectives

Studies on stem cells and regenerative mechanisms depend to a large extent on experimental models in animals. The phenotypic analysis of animal models is a prerequisite for the generation and verification of hypotheses. The major objective of this SU is to establish a novel interdisciplinary core unit which will bring together veterinarian expertise on laboratory animals with histopathological skills from different organ specialists in human pathology in order to enable optimal patho-anatomical interpretation of animal models for human disease and regeneration. Within this SU histopathological expertise is generated which will facilitate bridging between animal models and experimental therapy in patients.

Research Focus

Within the frame of REBIRTH the Institute for laboratory animals and the Institute of Pathology have erected and share a completely new and interdisciplinary service unit at the MHH (“xPa”), which has not existed before. xPa provides a platform for information (modes of fixation and storage of tissues), technical support (tissue sections and stain, immunhistochemistry, laser microdissection, RNA analysis), training (microscopical analysis) and histopathological diagnoses. The latter are rendered by registrars and well experienced experts in human pathology only. Since 2007 xPa was involved in 38 research projects from 21 different working groups and departments.

Further Research Projects

  • Definition of a workflow from planning of animal experiments to tissue analysis. Providing a methodological platform for advanced analysis of animal tissues including immunohistochemistry, laser-microdissection, expression analysis by RT-PCR

Teaching

  • istological training of scientists and Ph.D. students within the REBIRTH cluster of excellence

Publications

2013 - ongoing

2017

Abere B, Mamo TM, Hartmann S, Samarina N, Hage E, Ruckert J, Hotop SK, Busche G, Schulz TF. The Kaposi's sarcoma-associated herpesvirus (KSHV) non-structural membrane protein K15 is required for viral lytic replication and may represent a therapeutic target. PLoS Pathog. 2017;13(9):e1006639. Epub 2017/09/25.

Aichler M, Kunzke T, Buck A, Sun N, Ackermann M, Jonigk D, Gaumann A, Walch A. Molecular similarities and differences from human pulmonary fibrosis and corresponding mouse model: MALDI imaging mass spectrometry in comparative medicine. Lab Invest. 2017. Epub 2017/10/17.

Jeinsen N, Magel L, Jonigk D, Klingenberg M, Haverich A, Wilhelmi M, Boer U. Biocompatibility of Intensified Decellularized Equine Carotid Arteries in a Rat Subcutaneous Implantation Model and in a Human In Vitro Model. Tissue Eng Part A. 2017. Epub 2017/05/23.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Busche G, Fleck D, Muller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R. Gli1(+) Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell. 2017/05/02 ed2017. p. 785-800.e8.

Thorenz A, Volker N, Brasen JH, Chen R, Jang MS, Rong S, Haller H, Kirsch T, Vieten G, Klemann C, Gueler F. IL-17A blockade or deficiency does not affect progressive renal fibrosis following renal ischaemia reperfusion injury in mice. J Pharm Pharmacol. 2017;69(9):1125-35. Epub 2017/06/03.

Yang M, Pan Z, Huang K, Busche G, Feuerhake F, Chaturvedi A, Nie D, Heuser M, Thol F, von Neuhoff N, Ganser A, Li Z. Activation of TRKA receptor elicits mastocytosis in mice and is involved in the development of resistance to KIT-targeted therapy. Oncotarget. 2017;8(43):73871-83. Epub 2017/11/02.

Zhang R, Magel L, Jonigk D, Langer F, Lippmann T, Zardo P, Polzing F. Biosynthetic Nanostructured Cellulose Patch for Chest Wall Reconstruction: Five-Month Follow-up in a Porcine Model. J Invest Surg. 2017;30(5):297-302. Epub 2016/10/22.

Sommer W, Buechler G, Jansson K, Avsar M, Knofel AK, Salman J, Hoeffler K, Siemeni T, Gottlieb J, Karstens JH, Jonigk D, Reising A, Haverich A, Struber M, Warnecke G. Irradiation before and donor splenocyte infusion immediately after transplantation induce tolerance to lung, but not heart allografts in miniature swine. Transpl Int. 2017.

2016

Zhang R, Magel L, Jonigk D, Langer F, Lippmann T, Zardo P, Polzing F. Biosynthetic Nanostructured Cellulose Patch for Chest Wall Reconstruction: Five-Month Follow-up in a Porcine Model. J Invest Surg. 2016:1-6.

Zhang R, Bures M, Hoffler K, Jonigk D, Haverich A, Krueger M. In Vitro Comparison of Two Widely Used Surgical Sealants for Treating Alveolar Air Leak. Thorac Cardiovasc Surg. 2016.

Winny M, Grethe L, Maegel L, Jonigk D, Lippmann T, Klempnauer J, Poehnert D. Impairment of the Peritoneal Surface as a Decisive Factor for Intestinal Adhesions in Intraperitoneal Onlay Mesh Surgery - Introducing a New Rat Model. Int J Med Sci. 2016;13(2):108-12.

Siemeni T, Knofel AK, Madrahimov N, Sommer W, Avsar M, Salman J, Ius F, Frank N, Buchler G, Jonigk D, Jansson K, Maus U, Tudorache I, Falk CS, Haverich A, Warnecke G. In Vivo Development of Transplant Arteriosclerosis in Humanized Mice Reflects Alloantigen Recognition and Peripheral Treg Phenotype of Lung Transplant Recipients. Am J Transplant. 2016;16(11):3150-62.

Schneider RK, Schenone M, Ferreira MV, Kramann R, Joyce CE, Hartigan C, Beier F, Brummendorf TH, Germing U, Platzbecker U, Busche G, Knuchel R, Chen MC, Waters CS, Chen E, Chu LP, Novina CD, Lindsley RC, Carr SA, Ebert BL. Rps14 haploinsufficiency causes a block in erythroid differentiation mediated by S100A8 and S100A9. Nat Med. 2016;22(3):288-97.

Salari A, Thomay K, Himmler K, Vajen B, Schienke A, Hagedorn M, Ebersold J, Kreipe HH, Kruger A, Schambach A, Schlegelberger B, Gohring G. Establishing a murine xenograft-model for long-term analysis of factors inducing chromosomal instability in myelodysplastic syndrome: Pitfalls and successes. Cancer Genet. 2016;209(6):258-66.

Poehnert D, Grethe L, Maegel L, Jonigk D, Lippmann T, Kaltenborn A, Schrem H, Klempnauer J, Winny M. Evaluation of the Effectiveness of Peritoneal Adhesion Prevention Devices in a Rat Model. Int J Med Sci. 2016;13(7):524-32.

Pils MC, Dreckmann K, Jansson K, Glage S, Held N, Sommer W, Langer F, Avsar M, Warnecke G, Bleich A. Mortality Due to Porcine Reproductive and Respiratory Syndrome Virus in Immunocompromised Gottingen Minipigs (Sus scrofa domestica). Comp Med. 2016;66(5):392-8.

Kruger M, Zinne N, Biancosino C, Hoffler K, Rajab TK, Waldmann KH, Jonigk D, Avsar M, Haverich A, Hoeltig D. Porcine pulmonary auto-transplantation for ex vivo therapy as a model for new treatment strategies. Interact Cardiovasc Thorac Surg. 2016;23(3):358-66.

Khalili-Harbi N, Herath N, Solass W, Giger-Pabst U, Dutreix M, Reymond MA. Pressurized intraluminal aerosol chemotherapy with Dbait in the distal esophagus of swine. Endoscopy. 2016;48(2):184-7.

Kellner M, Heidrich M, Lorbeer RA, Antonopoulos GC, Knudsen L, Wrede C, Izykowski N, Grothausmann R, Jonigk D, Ochs M, Ripken T, Kuhnel MP, Meyer H. A combined method for correlative 3D imaging of biological samples from macro to nano scale. Scientific reports. 2016;6:35606.

Izykowski N, Kuehnel M, Hussein K, Mitschke K, Gunn M, Janciauskiene S, Haverich A, Warnecke G, Laenger F, Maus U, Jonigk D. Organizing pneumonia in mice and men. J Transl Med. 2016;14(1):169.

Hueper K, Gutberlet M, Brasen JH, Jang MS, Thorenz A, Chen R, Hertel B, Barrmeyer A, Schmidbauer M, Meier M, von Vietinghoff S, Khalifa A, Hartung D, Haller H, Wacker F, Rong S, Gueler F. Multiparametric Functional MRI: Non-Invasive Imaging of Inflammation and Edema Formation after Kidney Transplantation in Mice. PloS one. 2016;11(9):e0162705.

Huang K, Yang M, Pan Z, Heidel FH, Scherr M, Eder M, Fischer T, Busche G, Welte K, von Neuhoff N, Ganser A, Li Z. Leukemogenic potency of the novel FLT3-N676K mutant. Ann Hematol. 2016;95(5):783-91.

Hockendorf U, Yabal M, Herold T, Munkhbaatar E, Rott S, Jilg S, Kauschinger J, Magnani G, Reisinger F, Heuser M, Kreipe H, Sotlar K, Engleitner T, Rad R, Weichert W, Peschel C, Ruland J, Heikenwalder M, Spiekermann K, Slotta-Huspenina J, Gross O, Jost PJ. RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death and Differentiation of Leukemia Initiating Cells. Cancer Cell. 2016;30(1):75-91.

Hering T, Braubach P, Landwehrmeyer GB, Lindenberg KS, Melzer W. Fast-to-Slow Transition of Skeletal Muscle Contractile Function and Corresponding Changes in Myosin Heavy and Light Chain Formation in the R6/2 Mouse Model of Huntington's Disease. PloS one. 2016;11(11):e0166106.

Gren ST, Janciauskiene S, Sandeep S, Jonigk D, Kvist PH, Gerwien JG, Hakansson K, Grip O. The protease inhibitor cystatin C down-regulates the release of IL-beta and TNF-alpha in lipopolysaccharide activated monocytes. J Leukoc Biol. 2016;100(4):811-22.

Bures M, Zardo P, Langer F, Zhang R. Improved application technique of albumin-glutaraldehyde glue for repair of superficial lung defects. J Cardiothorac Surg. 2016;11(1):149.

Bures M, Hoffler HK, Friedel G, Kyriss T, Boedeker E, Langer F, Zardo P, Zhang R. Albumin-glutaraldehyde glue for repair of superficial lung defect: an in vitro experiment. J Cardiothorac Surg. 2016;11(1):63.

Behler-Janbeck F, Takano T, Maus R, Stolper J, Jonigk D, Tort Tarres M, Fuehner T, Prasse A, Welte T, Timmer MS, Stocker BL, Nakanishi Y, Miyamoto T, Yamasaki S, Maus UA. C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia. PLoS Pathog. 2016;12(12):e1006038.

Avsar M, Jansson K, Sommer W, Kruse B, Thissen S, Dreckmann K, Knoefel AK, Salman J, Hafer C, Hecker J, Buechler G, Karstens JH, Jonigk D, Langer F, Kaever V, Falk CS, Hewicker-Trautwein M, Ungefroren H, Haverich A, Struber M, Warnecke G. Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine. Am J Transplant. 2016;16(5):1371-82.

2015

Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, Jonigk D, Izykowski N, Magel L, Welte T, Yamasaki S, Maus UA. Macrophage-Inducible C-Type Lectin Mincle-Expressing Dendritic Cells Contribute to Control of Splenic Mycobacterium Bovis Bcg Infection in Mice. Infect Immun. 2015;83(1):184-96. Epub 2014/10/22.

Feng T, Dzieran J, Gu X, Marhenke S, Vogel A, Machida K, Weiss TS, Ruemmele P, Kollmar O, Hoffmann P, Grasser F, Allgayer H, Fabian J, Weng HL, Teufel A, Maass T, Meyer C, Lehmann U, Zhu C, Mertens PR, Gao CF, Dooley S, Meindl-Beinker NM. Smad7 Regulates Compensatory Hepatocyte Proliferation in Damaged Mouse Liver and Positively Relates to Better Clinical Outcome in Human Hepatocellular Carcinoma. Clin Sci (Lond). 2015;128(11):761-74.

Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, Falk CS, Ardesjo Lundgren B, Scott HS, Pich A, Anderson MS, Manns MP, Jaeckel E. Autoimmune Hepatitis in a Murine Autoimmune Polyendocrine Syndrome Type 1 Model Is Directed against Multiple Autoantigens. Hepatology. 2015;61(4):1295-305. Epub 2014/12/06.

Kohlscheen S, Wintterle S, Schwarzer A, Kamp C, Brugman MH, Breuer DC, Busche G, Baum C, Modlich U. Inhibition of Thrombopoietin/Mpl Signaling in Adult Hematopoiesis Identifies New Candidates for Hematopoietic Stem Cell Maintenance. PLoS One. 2015;10(7):e0131866.

Poehnert D, Abbas M, Maegel L, Sambale F, Lavrentieva A, Kreipe HH, Klempnauer J, Winny M. Evaluation of the Biological Tolerability of the Starch-Based Medical Device 4dryfield(R) Ph in Vitro and in Vivo a Rat Model. J Biomater Appl. 2015. Epub 2015/06/28.

Sommer W, Knofel AK, Izykowski N, Oldhafer F, Avsar M, Jonigk D, Warnecke G, Haverich A. Physical Exercise Reduces Transplant Arteriosclerosis in a Mouse Aorta Transplantation Model. J Thorac Cardiovasc Surg. 2015;149(1):330-7.

Sommer W, Knofel AK, Madrahimov N, Avsar M, Jonigk D, Salman J, Dreckmann K, Jansson K, Salguero G, Maus UA, Welte T, Haverich A, Warnecke G. Allogeneic Cd4+Cd25high T Cells Regulate Obliterative Bronchiolitis of Heterotopic Bronchus Allografts in Both Porcinized and Humanized Mouse Models. Transplantation. 2015;99(3):482-91. Epub 2015/02/20.

2014

Zhang R, Bures M, Hoffler K, Jonigk D, Haverich A, Krueger M. In Vitro Comparison of Two Widely Used Surgical Sealants for Treating Alveolar Air Leak. Thorac Cardiovasc Surg. 2014;62(8):705-9. Epub 2014/09/11.

Yang M, Huang K, Busche G, Ganser A, Li Z. Activation of Trkb Receptor in Murine Hematopoietic Stem/Progenitor Cells Induced Mastocytosis. Blood. 2014;124(7):1196-7. Epub 2014/08/16.

Salguero G, Daenthanasanmak A, Munz C, Raykova A, Guzman CA, Riese P, Figueiredo C, Langer F, Schneider A, Macke L, Sundarasetty BS, Witte T, Ganser A, Stripecke R. Dendritic Cell-Mediated Immune Humanization of Mice: Implications for Allogeneic and Xenogeneic Stem Cell Transplantation. J Immunol. 2014;192(10):4636-47.

Ramackers W, Friedrich L, Klose J, Vondran F, Bergmann S, Schuttler W, Johanning K, Werwitzke S, Trummer A, Brocker V, Klempnauer J, Winkler M, Tiede A. Recombinant Human Antithrombin Prevents Xenogenic Activation of Hemostasis in a Model of Pig-to-Human Kidney Transplantation. Xenotransplantation. 2014;21(4):367-75.

2013

Zell S, Schmitt R, Witting S, Kreipe HH, Hussein K, Becker JU. Hypoxia Induces Mesenchymal Gene Expression in Renal Tubular Epithelial Cells: An in Vitro Model of Kidney Transplant Fibrosis. Nephron Extra. 2013;3(1):50-8.

Yang M, Busche G, Ganser A, Li Z. Morphology and Quantitative Composition of Hematopoietic Cells in Murine Bone Marrow and Spleen of Healthy Subjects. Ann Hematol. 2013;92(5):587-94.

Yang M, Busche G, Ganser A, Li Z. Cytological Characterization of Murine Bone Marrow and Spleen Hematopoietic Compartments for Improved Assessment of Toxicity in Preclinical Gene Marking Models. Ann Hematol. 2013;92(5):595-604.

Wolf S, Rudolph C, Morgan M, Busche G, Salguero G, Stripecke R, Schlegelberger B, Baum C, Modlich U. Selection for Evi1 Activation in Myelomonocytic Leukemia Induced by Hyperactive Signaling through Wild-Type Nras. Oncogene. 2013;32(25):3028-38. Epub 2012/08/01.

Wende E, Laudeley R, Bleich A, Bleich E, Wetsel RA, Glage S, Klos A. The Complement Anaphylatoxin C3a Receptor (C3ar) Contributes to the Inflammatory Response in Dextran Sulfate Sodium (Dss)-Induced Colitis in Mice. PLoS One. 2013;8(4):e62257. Epub 2013/05/03.

Vajen B, Modlich U, Schienke A, Wolf S, Skawran B, Hofmann W, Busche G, Kreipe H, Baum C, Santos-Barriopedro I, Vaquero A, Schlegelberger B, Rudolph C. Histone Methyltransferase Suv39h1 Deficiency Prevents Myc-Induced Chromosomal Instability in Murine Myeloid Leukemias. Genes Chromosomes Cancer. 2013;52(4):423-30.

Neumann D, Beermann S, Burhenne H, Glage S, Hartwig C, Seifert R. The Dual H3/4r Antagonist Thioperamide Does Not Fully Mimic the Effects of the 'Standard' H4r Antagonist Jnj 7777120 in Experimental Murine Asthma. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(11):983-90.

Mandel K, Yang Y, Schambach A, Glage S, Otte A, Hass R. Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth in Vitro and in Vivo. Stem Cells Dev. 2013;22(23):3114-27.

Kotlarz D, Zietara N, Uzel G, Weidemann T, Braun CJ, Diestelhorst J, Krawitz PM, Robinson PN, Hecht J, Puchalka J, Gertz EM, Schaffer AA, Lawrence MG, Kardava L, Pfeifer D, Baumann U, Pfister ED, Hanson EP, Schambach A, Jacobs R, Kreipe H, Moir S, Milner JD, Schwille P, Mundlos S, Klein C. Loss-of-Function Mutations in the Il-21 Receptor Gene Cause a Primary Immunodeficiency Syndrome. J Exp Med. 2013;210(3):433-43.

Kezic A, Thaiss F, Becker JU, Tsui TY, Bajcetic M. Effects of Everolimus on Oxidative Stress in Kidney Model of Ischemia/Reperfusion Injury. Am J Nephrol. 2013;37(4):291-301.

Kezic A, Becker JU, Thaiss F. The Effect of Mtor-Inhibition on Nf-Kappab Activity in Kidney Ischemia-Reperfusion Injury in Mice. Transplant Proc. 2013;45(5):1708-14.

Karra N, Nassar T, Laenger F, Benita S, Borlak J. Safety and Proof-of-Concept Efficacy of Inhaled Drug Loaded Nano- and Immunonanoparticles in a C-Raf Transgenic Lung Cancer Model. Curr Cancer Drug Targets. 2013;13(1):11-29.

Hua X, Deuse T, Chen YJ, Wulff H, Stubbendorff M, Kohler R, Miura H, Langer F, Reichenspurner H, Robbins RC, Schrepfer S. The Potassium Channel Kca3.1 as New Therapeutic Target for the Prevention of Obliterative Airway Disease. Transplantation. 2013;95(2):285-92. Epub 2013/01/18.

Hesse D, Ehlert N, Luenhop T, Smoczek A, Glage S, Behrens P, Muller PP, Esser KH, Lenarz T, Stieve M, Bleich A, Prenzler NK. Nanoporous Silica Coatings as a Drug Delivery System for Ciprofloxacin: Outcome of Variable Release Rates in the Infected Middle Ear of Rabbits. Otol Neurotol. 2013;34(6):1138-45.

Hardtke-Wolenski M, Fischer K, Noyan F, Schlue J, Falk CS, Stahlhut M, Woller N, Kuehnel F, Taubert R, Manns MP, Jaeckel E. Genetic Predisposition and Environmental Danger Signals Initiate Chronic Autoimmune Hepatitis Driven by Cd4+ T Cells. Hepatology. 2013;58(2):718-28.

Haas DA, Bala K, Busche G, Weidner-Glunde M, Santag S, Kati S, Gramolelli S, Damas M, Dittrich-Breiholz O, Kracht M, Ruckert J, Varga Z, Keri G, Schulz TF. The Inflammatory Kinase Map4k4 Promotes Reactivation of Kaposi's Sarcoma Herpesvirus and Enhances the Invasiveness of Infected Endothelial Cells. PLoS Pathog. 2013;9(11):e1003737.

Dutow P, Lingner S, Laudeley R, Glage S, Hoymann HG, Dittrich AM, Fehlhaber B, Muller M, Braun A, Klos A. Severity of Allergic Airway Disease Due to House Dust Mite Allergen Is Not Increased after Clinical Recovery of Lung Infection with Chlamydia Pneumoniae in Mice. Infect Immun. 2013;81(9):3366-74. Epub 2013/07/03.

Boer U, Spengler C, Klingenberg M, Jonigk D, Harder M, Kreipe HH, Haverich A, Wilhelmi M. Cytotoxic Effects of Polyhexanide on Cellular Repopulation and Calcification of Decellularized Equine Carotids in Vitro and in Vivo. Int J Artif Organs. 2013;36(3):184-94.

Boer U, Spengler C, Jonigk D, Klingenberg M, Schrimpf C, Lutzner S, Harder M, Kreipe HH, Haverich A, Wilhelmi M. Coating Decellularized Equine Carotid Arteries with Ccn1 Improves Cellular Repopulation, Local Biocompatibility, and Immune Response in Sheep. Tissue Eng Part A. 2013;19(15-16):1829-42.

Atanasova S, Hirschburger M, Jonigk D, Obert M, Petri K, Evers A, Hecker A, Schmitz J, Kaufmann A, Wilhelm J, Chakraborty T, Warnecke G, Gottlieb J, Padberg W, Grau V. A Relevant Experimental Model for Human Bronchiolitis Obliterans Syndrome. J Heart Lung Transplant. 2013;32(11):1131-9.

2006 - 2012

2012

Böer U, Lutzner S, Jonigk D, Klingenberg M, Haverich A, Wilhelmi M. Effect of CCN1 coating of decellularized equine carotid arteries on local biocompatibility and humoral immunogenicity in a heterogenous animal model. Biomed Tech (Berl). 2012. Epub 2012/09/05.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84. Epub 2012/12/01.

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Steinwede K, Maus R, Bohling J, Voedisch S, Braun A, Ochs M, Schmiedl A, Langer F, Gauthier F, Roes J, Welte T, Bange FC, Niederweis M, Buhling F, Maus UA. Cathepsin G and Neutrophil Elastase Contribute to Lung-Protective Immunity against Mycobacterial Infections in Mice. J Immunol. 2012;188(9):4476-87. Epub 2012/03/31.

Skokowa J, Klimiankou M, Klimenkova O, Lan D, Gupta K, Hussein K, Carrizosa E, Kusnetsova I, Li Z, Sustmann C, Ganser A, Zeidler C, Kreipe HH, Burkhardt J, Grosschedl R, Welte K. Interactions among Hcls1, Hax1 and Lef-1 Proteins Are Essential for G-Csf-Triggered Granulopoiesis. Nat Med. 2012;18(10):1550-9. Epub 2012/09/25.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Otte A, Gohring G, Steinemann D, Schlegelberger B, Groos S, Langer F, Kreipe HH, Schambach A, Neumann T, Hillemanns P, Park-Simon TW, Hass R. A Tumor-Derived Population (Sccoht-1) as Cellular Model for a Small Cell Ovarian Carcinoma of the Hypercalcemic Type. Int J Oncol. 2012;41(2):765-75.

Hunecke D, Spanel R, Langer F, Nam SW, Borlak J. Myc-Regulated Genes Involved in Liver Cell Dysplasia Identified in a Transgenic Model of Liver Cancer. J Pathol. 2012;228(4):520-33.

Hueper K, Elalfy M, Laenger F, Halter R, Rodt T, Galanski M, Borlak J. Pet/Ct Imaging of C-Myc Transgenic Mice Identifies the Genotoxic N-Nitroso-Diethylamine as Carcinogen in a Short-Term Cancer Bioassay. PLoS One. 2012;7(2):e30432. Epub 2012/02/10.

Buurman R, Gurlevik E, Schaffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kuhnel F, Skawran B. Histone Deacetylases Activate Hepatocyte Growth Factor Signaling by Repressing Microrna-449 in Hepatocellular Carcinoma Cells. Gastroenterology. 2012;143(3):811-20 e1-15.

Beermann S, Glage S, Jonigk D, Seifert R, Neumann D. Opposite Effects of Mepyramine on Jnj 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation. PLoS One. 2012;7(1):e30285.

2011

Steinwede K, Tempelhof O, Bolte K, Maus R, Bohling J, Ueberberg B, Langer F, Christman JW, Paton JC, Ask K, Maharaj S, Kolb M, Gauldie J, Welte T, Maus UA. Local Delivery of Gm-Csf Protects Mice from Lethal Pneumococcal Pneumonia. J Immunol. 2011;187(10):5346-56.

Seth S, Ravens I, Lee CW, Glage S, Bleich A, Forster R, Bernhardt G, Koenecke C. Absence of Cd155 Aggravates Acute Graft-Versus-Host Disease. Proc Natl Acad Sci U S A. 2011;108(10):E32-3; author reply E4.

Pincha M, Salguero G, Wedekind D, Sundarasetty BS, Lin A, Kasahara N, Brugman MH, Jirmo AC, Modlich U, Gutzmer R, Busche G, Ganser A, Stripecke R. Lentiviral Vectors for Induction of Self-Differentiation and Conditional Ablation of Dendritic Cells. Gene Ther. 2011;18(8):750-64.

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T. Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases. PLoS One. 2011;6(12):e28911.

Northrup E, Eisenblatter R, Glage S, Rudolph C, Dorsch M, Schlegelberger B, Hedrich HJ, Zschemisch NH. Loss of Dnd1 Facilitates the Cultivation of Genital Ridge-Derived Rat Embryonic Germ Cells. Exp Cell Res. 2011;317(13):1885-94.

Meyer-Schwesinger C, Lange C, Brocker V, Agustian P, Lehmann U, Raabe A, Brinkmeyer M, Kobayashi E, Schiffer M, Busche G, Kreipe HH, Thaiss F, Becker JU. Bone Marrow-Derived Progenitor Cells Do Not Contribute to Podocyte Turnover in the Puromycin Aminoglycoside and Renal Ablation Models in Rats. Am J Pathol. 2011;178(2):494-9. Epub 2011/02/02.

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I. Induced Pluripotent Stem Cell (Ipsc)-Derived Flk-1 Progenitor Cells Engraft, Differentiate, and Improve Heart Function in a Mouse Model of Acute Myocardial Infarction. Eur Heart J. 2011;32(21):2634-41.

Kleinschmidt K, Klinge PM, Stopa E, Wallrapp C, Glage S, Geigle P, Brinker T. Alginate Encapsulated Human Mesenchymal Stem Cells Suppress Syngeneic Glioma Growth in the Immunocompetent Rat. J Microencapsul. 2011;28(7):621-7.

Heckl D, Wicke DC, Brugman MH, Meyer J, Schambach A, Busche G, Ballmaier M, Baum C, Modlich U. Lentiviral Gene Transfer Regenerates Hematopoietic Stem Cells in a Mouse Model for Mpl-Deficient Aplastic Anemia. Blood. 2011;117(14):3737-47.

2010

Wiegmann B, Zardo P, Dickgreber N, Langer F, Fegbeutel C, Haverich A, Fischer S. Biological Materials in Chest Wall Reconstruction: Initial Experience with the Peri-Guard Repair Patch. Eur J Cardiothorac Surg. 2010;37(3):602-5.

Wicke DC, Meyer J, Buesche G, Heckl D, Kreipe H, Li Z, Welte KH, Ballmaier M, Baum C, Modlich U. Gene Therapy of Mpl Deficiency: Challenging Balance between Leukemia and Pancytopenia. Mol Ther. 2010;18(2):343-52. Epub 2009/10/22.

Poehnert D, Broecker V, Mengel M, Nashan B, Koch M. Induction of Chronic Renal Allograft Dysfunction in a Rat Model with Complete and Exclusive Mhc Incompatibility. Transpl Immunol. 2010;22(3-4):137-43.

Nolff MC, Kokemueller H, Hauschild G, Fehr M, Bormann KH, Spalthoff S, Rohn K, Ruecker M, Gellrich NC. Comparison of Computed Tomography and Microradiography for Graft Evaluation after Reconstruction of Critical Size Bone Defects Using Beta-Tricalcium Phosphate. J Craniomaxillofac Surg. 2010;38(1):38-46. Epub 2009/08/25.

Kokemueller H, Spalthoff S, Nolff M, Tavassol F, Essig H, Stuehmer C, Bormann KH, Rucker M, Gellrich NC. Prefabrication of Vascularized Bioartificial Bone Grafts in Vivo for Segmental Mandibular Reconstruction: Experimental Pilot Study in Sheep and First Clinical Application. Int J Oral Maxillofac Surg. 2010;39(4):379-87.

Hesse E, Kluge G, Atfi A, Correa D, Haasper C, Berding G, Shin HO, Viering J, Langer F, Vogt PM, Krettek C, Jagodzinski M. Repair of a Segmental Long Bone Defect in Human by Implantation of a Novel Multiple Disc Graft. Bone. 2010;46(5):1457-63.

Christgen M, Geffers R, Ballmaier M, Christgen H, Poczkaj J, Krech T, Kreipe H, Lehmann U. Down-Regulation of the Fetal Stem Cell Factor Sox17 by H33342: A Mechanism Responsible for Differential Gene Expression in Breast Cancer Side Population Cells. J Biol Chem. 2010;285(9):6412-8.

Bisdas T, Bredt M, Pichlmaier M, Aper T, Wilhelmi M, Bisdas S, Haverich A, Teebken OE. Eight-Year Experience with Cryopreserved Arterial Homografts for the in Situ Reconstruction of Abdominal Aortic Infections. J Vasc Surg. 2010;52(2):323-30.

2009

Zhao F, Vermeer B, Lehmann U, Kreipe H, Manns MP, Korangy F, Greten TF. Identification of a Novel Murine Pancreatic Tumour Antigen, Which Elicits Antibody Responses in Patients with Pancreatic Carcinoma. Immunology. 2009;128(1):134-40. Epub 2009/08/20.

Winter C, Herbold W, Maus R, Langer F, Briles DE, Paton JC, Welte T, Maus UA. Important Role for Cc Chemokine Ligand 2-Dependent Lung Mononuclear Phagocyte Recruitment to Inhibit Sepsis in Mice Infected with Streptococcus Pneumoniae. J Immunol. 2009;182(8):4931-7.

Warnecke G, Hutchinson JA, Riquelme P, Kruse B, Thissen S, Avsar M, Zehle G, Steinkamp T, Peters C, Baumann R, Govert F, Ungefroren H, Langer F, Simon AR, Karstens JH, Kaever V, Haverich A, Fandrich F, Struber M. Postoperative Intravenous Infusion of Donor-Derived Transplant Acceptance-Inducing Cells as an Adjunct Immunosuppressive Therapy in a Porcine Pulmonary Allograft Model. Transpl Int. 2009;22(3):332-41. Epub 2008/10/29.

Singh AK, Riederer B, Krabbenhoft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential Roles of Nherf1, Nherf2, and Pdzk1 in Regulating Cftr-Mediated Intestinal Anion Secretion in Mice. J Clin Invest. 2009;119(3):540-50.

Schmitt R, Jacobi C, Susnik N, Broecker V, Haller H, Melk A. Ageing Mouse Kidney--Not Always the Same Old Story. Nephrol Dial Transplant. 2009;24(10):3002-5. Epub 2009/05/29.

Kruse B, Thissen S, Warnecke G, Avsar M, Gottlieb J, Hohlfeld JM, Karstens JH, Kaever V, Langer F, Pabst B, Ungefroren H, Haverich A, Struber M. Correlation of Donor Leukocyte Chimerism with Pulmonary Allograft Survival after Immunosuppressive Drug Withdrawal in a Porcine Model. Transplantation. 2009;87(10):1468-77.

Kocks JR, Adler H, Danzer H, Hoffmann K, Jonigk D, Lehmann U, Forster R. Chemokine Receptor Ccr7 Contributes to a Rapid and Efficient Clearance of Lytic Murine Gamma-Herpes Virus 68 from the Lung, Whereas Bronchus-Associated Lymphoid Tissue Harbors Virus During Latency. J Immunol. 2009;182(11):6861-9.

Huber TB, Hartleben B, Winkelmann K, Schneider L, Becker JU, Leitges M, Walz G, Haller H, Schiffer M. Loss of Podocyte Apkclambda/Iota Causes Polarity Defects and Nephrotic Syndrome. J Am Soc Nephrol. 2009;20(4):798-806.

Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR, Martin U. Generation of Induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell. 2009;5(4):434-41.

Ghosh A, Koestner W, Hapke M, Schlaphoff V, Langer F, Baumann R, Koenecke C, Cornberg M, Welte K, Blazar BR, Sauer MG. Donor T Cells Primed on Leukemia Lysate-Pulsed Recipient Apcs Mediate Strong Graft-Versus-Leukemia Effects across Mhc Barriers in Full Chimeras. Blood. 2009;113(18):4440-8.

2008

Fischer K, Wolenski M, Manns MP, Jaeckel E. A new animal model of chronic autoimmune hepatitis mediated by the adaptive immune system. Paper presented at: 2008 EASL Monothematic Conference: Immune Mediated Liver Injury; Hamburg, Dec. 4-6, 2008.

Srivastava M, Steinwede K, Kiviranta R, Morko J, Hoymann HG, Langer F, Buhling F, Welte T, Maus UA. Overexpression of Cathepsin K in Mice Decreases Collagen Deposition and Lung Resistance in Response to Bleomycin-Induced Pulmonary Fibrosis. Respir Res. 2008;9:54.

Schubert S, Kamino K, Bohm D, Adham I, Engel W, von Wasielewski R, Moharregh-Khiabani D, Mauceri G, Vaske B, Meinhardt A, Schoner A, Gonzalez-Fassrainer D, Schmidtke J. Tspy Expression Is Variably Altered in Transgenic Mice with Testicular Feminization. Biol Reprod. 2008;79(1):125-33. Epub 2008/04/11.

Schreiber O, Steinwede K, Ding N, Srivastava M, Maus R, Länger F, Prokein J, Ehlers S, Welte T, Gunn MD, Maus UA. Mice That Overexpress Cc Chemokine Ligand 2 in Their Lungs Show Increased Protective Immunity to Infection with Mycobacterium Bovis Bacille Calmette-Guérin. Journal of Infectious Diseases. 2008;198(7):1044-54.

Nickel N, Kempf T, Tapken H, Tongers J, Laenger F, Lehmann U, Golpon H, Olsson K, Wilkins MR, Gibbs JS, Hoeper MM, Wollert KC. Growth Differentiation Factor-15 in Idiopathic Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2008;178(5):534-41.

Metzelder M, Kuebler J, Shimotakahara A, Vieten G, von Wasielewski R, Ure BM. Co(2) Pneumoperitoneum Increases Systemic but Not Local Tumor Spread after Intraperitoneal Murine Neuroblastoma Spillage in Mice. Surg Endosc. 2008;22(12):2648-53. Epub 2008/02/14.

Ma B, Wang L, von Wasielewski R, Lindenmaier W, Dittmar KE. Serial Sectioning and Three-Dimensional Reconstruction of Mouse Peyer's Patch. Micron. 2008;39(7):967-75.

Lamle J, Marhenke S, Borlak J, von Wasielewski R, Eriksson CJ, Geffers R, Manns MP, Yamamoto M, Vogel A. Nuclear Factor-Eythroid 2-Related Factor 2 Prevents Alcohol-Induced Fulminant Liver Injury. Gastroenterology. 2008;134(4):1159-68.

Haile LA, von Wasielewski R, Gamrekelashvili J, Kruger C, Bachmann O, Westendorf AM, Buer J, Liblau R, Manns MP, Korangy F, Greten TF. Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease: A New Immunoregulatory Pathway. Gastroenterology. 2008;135(3):871-81, 81 e1-5.

Bleich A, Sundberg JP, Smoczek A, von Wasielewski R, de Buhr MF, Janus LM, Julga G, Ukena SN, Hedrich HJ, Gunzer F. Sensitivity to Escherichia Coli Nissle 1917 in Mice Is Dependent on Environment and Genetic Background. Int J Exp Pathol. 2008;89(1):45-54. Epub 2007/11/17.

2007

Winter C, Taut K, Srivastava M, Langer F, Mack M, Briles DE, Paton JC, Maus R, Welte T, Gunn MD, Maus UA. Lung-Specific Overexpression of Cc Chemokine Ligand (Ccl) 2 Enhances the Host Defense to Streptococcus Pneumoniae Infection in Mice: Role of the Ccl2-Ccr2 Axis. J Immunol. 2007;178(9):5828-38.

Winter C, Taut K, Langer F, Mack M, Briles DE, Paton JC, Maus R, Srivastava M, Welte T, Maus UA. Fms-Like Tyrosine Kinase 3 Ligand Aggravates the Lung Inflammatory Response to Streptococcus Pneumoniae Infection in Mice: Role of Dendritic Cells. J Immunol. 2007;179(5):3099-108.

Ma B, von Wasielewski R, Lindenmaier W, Dittmar KE. Immmunohistochemical Study of the Blood and Lymphatic Vasculature and the Innervation of Mouse Gut and Gut-Associated Lymphoid Tissue. Anat Histol Embryol. 2007;36(1):62-74.

Lenarz M, Lim HH, Lenarz T, Reich U, Marquardt N, Klingberg MN, Paasche G, Reuter G, Stan AC. Auditory Midbrain Implant: Histomorphologic Effects of Long-Term Implantation and Electric Stimulation of a New Deep Brain Stimulation Array. Otol Neurotol. 2007;28(8):1045-52.

Gamrekelashvili J, Kruger C, von Wasielewski R, Hoffmann M, Huster KM, Busch DH, Manns MP, Korangy F, Greten TF. Necrotic Tumor Cell Death in Vivo Impairs Tumor-Specific Immune Responses. J Immunol. 2007;178(3):1573-80.

Christgen M, Ballmaier M, Bruchhardt H, von Wasielewski R, Kreipe H, Lehmann U. Identification of a Distinct Side Population of Cancer Cells in the Cal-51 Human Breast Carcinoma Cell Line. Mol Cell Biochem. 2007;306(1-2):201-12.

Bocchia M, Vannucchi AM, Gozzetti A, Guglielmelli P, Poli G, Crupi R, Defina M, Bosi A, Francesco L. Insights into Jak2-V617f Mutation in Cml. Lancet Oncol. 2007;8(10):864-6. Epub 2007/10/05.

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