Histopathology of Animal Models and Teratoma - Veterinary Pathology

Objectives

We provide a competent platform for histopathological analyses of animal models and stem cell research.

Research Focus

This Unit, located in the Institute for Laboratory Animal Science, works closely with various groups from the MHH as well as other institutions, by processing histological samples and providing tailored advice for project-specific morphological and histopathological questions. Routinely, this includes teratoma diagnostic in stem cell research. We assist working groups prior to the start of a project in order to find the most effective approach to acquire correct histological data. 

Additionally, we develop project-specific methods/sections, staining and analysis. Essentially, the development of a histopathologic score and blinded analysis by a trained pathologist is inevitable in order to provide the scientific investigator with reliable, significant, and publishable scientific data. Additionally, we have the ability to perform haematological analysis of different laboratory species (SCIL Vet ABC) and measure a broad spectrum of serum parameters (Olympus AU 400). At the moment, we are collecting data to establish the basic hematologic and serum parameters of the commonly used mouse and rat strains to provide our cooperation partners with. 

With our collaboration partners, the Institute for Pathology and the ITEM, we have access to a broad network with scientific expertise and state of the art equipment.

Collaborations

  • U. Martin, S. Wunderlich, Ch. Mauritz, REBIRTH Unit iPSCs for Disease Modelling. Drug Screening and Cell Therapy, LEBAO, MHH, Teratoma Diagnostic
  • Th. Moritz, Rebirth Unit iPSCs based Haematopoietic Regeneration, MHH, Teratoma Diagnostic
  • Th. Müller, former REBIRTH Unit Embryonic Stem Cells, Institute for Transfusion Medicine, MHH, Teratoma Diagnostic
  • M. Dorsch, N.-H. Zschemisch, former REBIRTH Unit Embryonic Stem Cells, Institute for Laboratory Animal Science, MHH, Teratoma Diagnostic
  • T. Cathomen, Transfusion Medicine, Universitätsklinikum Freiburg, Teratoma Diagnostic
  • Ch. Baum, E. Coci, Institute of Experimental Hematology, MHH; Characterisation of a wasp-ko mouse model
  • M. Dorsch, D. Wedekind, Institute for Laboratory Animal Science MHH; Characterisation of a rag-ko rat model
  • M. Meier, REBIRTH Unit Small Animal MRI, Institute for Laboratory Animal Science, MHH; Combined Analysis of a rat model with deafness in histology and MRT
  • H. Niemann, St. Petkov, REBIRTH Unit Large Animal Models, Federal Research Institute for Animal Health, Mariensee; Stem cell characterisation in a teratoma assay.
  • Klos, Med. Mikrobiologie, MHH; Chalmydia pneumoniea and asthma bronchiale in a mouse model.
  • T. Sparwasser, TWINCORE; Immune mechanisms in an asthma mouse model post infection by S. typhimurium.
  • P. Almeida, Helmholtz Centre for Infection Research; Role of IFNg for the regulation of iNOS in a mouse model for influenza lung infection.
  • A. Pich, B. Chatterji, Institute for Toxicology, MHH; MALDI Imaging and Proteomics of rat brain in a rat model for Usher Syndrome.
  • D. Wedekind, Institute for Laboratory Animal Science, MHH; Functional analysis of T-cell dysregulation, dysfunction and dysmaturation in a rat model for human autoimmune diabetes.

Publications

2013 - ongoing

2018

Basic M, Buettner M, Keubler LM, Smoczek A, Bruesch I, Buchheister S, Bleich A. Loss of CD14 leads to disturbed epithelial-B cell crosstalk and impairment of the intestinal barrier after E. coli Nissle monoassociation. Sci Rep. 2018;8(1):719.

Pan Z, Yang M, Huang K, Busche G, Glage S, Ganser A, Li Z. Flow cytometric characterization of acute leukemia reveals a distinctive "blast gate" of murine T-lymphoblastic leukemia/lymphoma. Oncotarget. 2018;9(2):2320-8.

Raap M, Gronewold M, Christgen H, Glage S, Bentires-Alj M, Koren S, Derksen PW, Boelens M, Jonkers J, Lehmann U, Feuerhake F, Kuehnle E, Gluz O, Kates R, Nitz U, Harbeck N, Kreipe HH, Christgen M. Lobular carcinoma in situ and invasive lobular breast cancer are characterized by enhanced expression of transcription factor AP-2beta. Lab Invest. 2018;98(1):117-29.

2017

Buchheister S, Buettner M, Basic M, Noack A, Breves G, Buchen B, Keubler LM, Becker C, Bleich A. CD14 Plays a Protective Role in Experimental Inflammatory Bowel Disease by Enhancing Intestinal Barrier Function. American Journal of Pathology. 2017;187(5):1106-20.

 

Glage S, Paret S, Winkel A, Stiesch M, Bleich A, Krauss JK, Schwabe K. A new model for biofilm formation and inflammatory tissue reaction: intraoperative infection of a cranial implant with Staphylococcus aureus in rats. Acta Neurochir (Wien). 2017;159(9):1747-56.

Hageri C, Biernot S, Buettner M, Glage S, Keubler LM, Held N, Bleich EM, Otto K, Muller CW, Decker S, Talbot SR, Bleich A. The Sheep Grimace Scale as an indicator of post-operative distress and pain in laboratory sheep. Plos One. 2017;12(4).

 

Petkov SG, Glage S, Niemann H. Mouse iPSC generated with porcine reprogramming factors as a model for studying the effects of non-silenced heterologous transgenes on pluripotency. J Stem Cells Regen Med. 2017;13(1):20-8.

Redhu NS, Bakthavatchalu V, Conway EA, Shouval DS, Tsou A, Goettel JA, Biswas A, Wang CW, Field M, Muller W, Bleich A, Li N, Gerber GK, Bry L, Fox JG, Snapper SB, Horwitz BH. Macrophage dysfunction initiates colitis during weaning of infant mice lacking the interleukin-10 receptor. Elife. 2017;6.

 

Schrimpf C, Wrede C, Glage S, Hegermann J, Backhaus S, Blasczyk R, Heuft HG, Muller T. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus). Transfusion. 2017;57(1):60-9.

Sunderhauf A, Skibbe K, Preisker S, Ebbert K, Verschoor A, Karsten CM, Kemper C, Huber-Lang M, Basic M, Bleich A, Buning J, Fellermann K, Sina C, Derer S. Regulation of epithelial cell expressed C3 in the intestine - Relevance for the pathophysiology of inflammatory bowel disease? Molecular Immunology. 2017;90:227-38.

 

Thiemann S, Smit N, Roy U, Lesker TR, Galvez EJC, Helmecke J, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T. Enhancement of IFN gamma Production by Distinct Commensals Ameliorates Salmonella-Induced Disease. Cell Host & Microbe. 2017;21(6):682-+.

2016

Zschemisch NH, Brusch I, Hambusch AS, Bleich A. Transcription Factor SP2 Enhanced the Expression of Cd14 in Colitis-Susceptible C3H/HeJBir. PloS one. 2016;11(5):e0155821.

Witt L, Glage S, Lichtinghagen R, Pape L, Boethig D, Dennhardt N, Heiderich S, Leffler A, Sumpelmann R. Impact of high doses of 6% hydroxyethyl starch 130/0.42 and 4% gelatin on renal function in a pediatric animal model. Paediatr Anaesth. 2016;26(3):259-65.

Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M. Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology. Stem cells translational medicine. 2016;5(5):591-601.

Rausch P, Basic M, Batra A, Bischoff SC, Blaut M, Clavel T, Glasner J, Gopalakrishnan S, Grassl GA, Gunther C, Haller D, Hirose M, Ibrahim S, Loh G, Mattner J, Nagel S, Pabst O, Schmidt F, Siegmund B, Strowig T, Volynets V, Wirtz S, Zeissig S, Zeissig Y, Bleich A, Baines JF. Analysis of factors contributing to variation in the C57BL/6J fecal microbiota across German animal facilities. Int J Med Microbiol. 2016;306(5):343-55.

Pils MC, Dreckmann K, Jansson K, Glage S, Held N, Sommer W, Langer F, Avsar M, Warnecke G, Bleich A. Mortality Due to Porcine Reproductive and Respiratory Syndrome Virus in Immunocompromised Gottingen Minipigs (Sus scrofa domestica). Comp Med. 2016;66(5):392-8.

Peuker K, Muff S, Wang J, Kunzel S, Bosse E, Zeissig Y, Luzzi G, Basic M, Strigli A, Ulbricht A, Kaser A, Arlt A, Chavakis T, van den Brink GR, Schafmayer C, Egberts JH, Becker T, Bianchi ME, Bleich A, Rocken C, Hampe J, Schreiber S, Baines JF, Blumberg RS, Zeissig S. Epithelial calcineurin controls microbiota-dependent intestinal tumor development. Nat Med. 2016;22(5):506-15.

Petkov S, Glage S, Nowak-Imialek M, Niemann H. Long-Term Culture of Porcine Induced Pluripotent Stem-Like Cells Under Feeder-Free Conditions in the Presence of Histone Deacetylase Inhibitors. Stem Cells Dev. 2016;25(5):386-94.

Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kuhnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem cell reports. 2016;7(2):292-305.

Hager C, Glage S, Held N, Bleich EM, Burghard A, Mahler M, Bleich A. Detection of antibodies against Theiler's murine encephalomyelitis virus GDVII strain in experimental guinea pigs. Lab Anim. 2016;50(5):400-3.

Elmore SA, Dixon D, Hailey JR, Harada T, Herbert RA, Maronpot RR, Nolte T, Rehg JE, Rittinghausen S, Rosol TJ, Satoh H, Vidal JD, Willard-Mack CL, Creasy DM. Recommendations from the INHAND Apoptosis/Necrosis Working Group. Toxicol Pathol. 2016;44(2):173-88.

Dutow P, Wask L, Bothe M, Fehlhaber B, Laudeley R, Rheinheimer C, Yang Z, Zhong G, Glage S, Klos A. An optimized, fast-to-perform mouse lung infection model with the human pathogen Chlamydia trachomatis for in vivo screening of antibiotics, vaccine candidates and modified host-pathogen interactions. Pathog Dis. 2016;74(2).

Dupont A, Sommer F, Zhang K, Repnik U, Basic M, Bleich A, Kuhnel M, Backhed F, Litvak Y, Fulde M, Rosenshine I, Hornef MW. Age-Dependent Susceptibility to Enteropathogenic Escherichia coli (EPEC) Infection in Mice. PLoS Pathog. 2016;12(5):e1005616.

2015

Milanez-Almeida P, Ulas T, Pasztoi M, Glage S, Schughart K, Lutz MB, Schultze JL, Huehn J. CD11b(+)Ly6C(++)Ly6G(-) Cells with Suppressive Activity Towards T Cells Accumulate in Lungs of Influenza a Virus-Infected Mice. Eur J Microbiol Immunol (Bp). 2015;5(4):246-55.

Schaubeck M, Clavel T, Calasan J, Lagkouvardos I, Haange SB, Jehmlich N, Basic M, Dupont A, Hornef M, Bergen MV, Bleich A, Haller D. Dysbiotic Gut Microbiota Causes Transmissible Crohn's Disease-Like Ileitis Independent of Failure in Antimicrobial Defence. Gut. 2015. Epub 2015/04/19.

Torow N, Yu K, Hassani K, Freitag J, Schulz O, Basic M, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Forster R, Pabst O, Hornef MW. Active Suppression of Intestinal Cd4(+)Tcralphabeta(+) T-Lymphocyte Maturation During the Postnatal Period. Nat Commun. 2015;6:7725. Epub 2015/07/22.

Ginzburg K, Kutz I, Koifman B, Roth A, Kriwisky M, David D, Bleich A. Acute Stress Disorder Symptoms Predict All-Cause Mortality among Myocardial Infarction Patients: A 15-Year Longitudinal Study. Ann Behav Med. 2015. Epub 2015/10/29.

Volynets V, Reichold A, Bardos G, Rings A, Bleich A, Bischoff SC. Assessment of the Intestinal Barrier with Five Different Permeability Tests in Healthy C57bl/6j and Balb/Cj Mice. Dig Dis Sci. 2015. Epub 2015/11/02.

Duda F, Bradel S, Bleich A, Abendroth P, Heemeier T, Ehlert N, Behrens P, Esser KH, Lenarz T, Brandes G, Prenzler NK. Biocompatibility of Silver Containing Silica Films on Bioverit(R) Ii Middle Ear Prostheses in Rabbits. J Biomater Appl. 2015;30(1):17-29. Epub 2015/02/11.

Yeruva S, Chodisetti G, Luo M, Chen M, Cinar A, Ludolph L, Lunnemann M, Goldstein J, Singh AK, Riederer B, Bachmann O, Bleich A, Gereke M, Bruder D, Hagen S, He P, Yun C, Seidler U. Evidence for a Causal Link between Adaptor Protein Pdzk1 Downregulation and Na(+)/H(+) Exchanger Nhe3 Dysfunction in Human and Murine Colitis. Pflugers Arch. 2015;467(8):1795-807. Epub 2014/10/02.

Gunther C, Buchen B, He GW, Hornef M, Torow N, Neumann H, Wittkopf N, Martini E, Basic M, Bleich A, Watson AJ, Neurath MF, Becker C. Caspase-8 Controls the Gut Response to Microbial Challenges by Tnf-Alpha-Dependent and Independent Pathways. Gut. 2015;64(4):601-10. Epub 2014/11/08.

Keenan CM, Baker J, Bradley A, Goodman DG, Harada T, Herbert R, Kaufmann W, Kellner R, Mahler B, Meseck E, Nolte T, Rittinghausen S, Vahle J, Yoshizawa K. International Harmonization of Nomenclature and Diagnostic Criteria (Inhand): Progress to Date and Future Plans. Toxicol Pathol. 2015;43(5):730-2. Epub 2014/12/23.

Nicklas W, Keubler L, Bleich A. Maintaining and Monitoring the Defined Microbiota Status of Gnotobiotic Rodents. ILAR J. 2015;56(2):241-9. Epub 2015/09/02.

Hartwig C, Munder A, Glage S, Wedekind D, Schenk H, Seifert R, Neumann D. The Histamine H4 -Receptor (H4 R) Regulates Eosinophilic Inflammation in Ovalbumin-Induced Experimental Allergic Asthma in Mice. Eur J Immunol. 2015;45(4):1129-40. Epub 2014/12/17.

Schirmer B, Wedekind D, Glage S, Neumann D. Deletion of Il-18 Expression Ameliorates Spontaneous Kidney Failure in Mrllpr Mice. PLoS One. 2015;10(10):e0140173. Epub 2015/10/16.

Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Niemann H, Kues WA. Derivation and Characterization of Bovine Induced Pluripotent Stem Cells by Transposon-Mediated Reprogramming. Cell Reprogram. 2015;17(2):131-40. Epub 2015/04/01.

Lindner C, Thomsen I, Wahl B, Ugur M, Sethi MK, Friedrichsen M, Smoczek A, Ott S, Baumann U, Suerbaum S, Schreiber S, Bleich A, Gaboriau-Routhiau V, Cerf-Bensussan N, Hazanov H, Mehr R, Boysen P, Rosenstiel P, Pabst O. Diversification of Memory B Cells Drives the Continuous Adaptation of Secretory Antibodies to Gut Microbiota. Nat Immunol. 2015;16(8):880-8. Epub 2015/07/07.

Rausch P, Steck N, Suwandi A, Seidel JA, Kunzel S, Bhullar K, Basic M, Bleich A, Johnsen JM, Vallance BA, Baines JF, Grassl GA. Expression of the Blood-Group-Related Gene B4galnt2 Alters Susceptibility to Salmonella Infection. PLoS Pathog. 2015;11(7):e1005008. Epub 2015/07/03.

Out C, Patankar JV, Doktorova M, Boesjes M, Bos T, de Boer S, Havinga R, Wolters H, Boverhof R, van Dijk TH, Smoczek A, Bleich A, Sachdev V, Kratky D, Kuipers F, Verkade HJ, Groen AK. Gut Microbiota Inhibit Asbt-Dependent Intestinal Bile Acid Reabsorption Via Gata4. J Hepatol. 2015;63(3):697-704. Epub 2015/05/30.

Bleich A, Fox JG. The Mammalian Microbiome and Its Importance in Laboratory Animal Research. ILAR J. 2015;56(2):153-8. Epub 2015/09/02.

Keubler LM, Buettner M, Häger C, Bleich A. A Multihit Model: Colitis Lessons from the Interleukin-10–Deficient Mouse. Inflammatory Bowel Diseases. 2015;21(8):1967-75.

Hager C, Keubler LM, Biernot S, Dietrich J, Buchheister S, Buettner M, Bleich A. Time to Integrate to Nest Test Evaluation in a Mouse Dss-Colitis Model. PLoS One. 2015;10(12):e0143824. Epub 2015/12/05.

2014

Witt L, Glage S, Schulz K, Lichtinghagen R, Simann A, Pape L, Sumpelmann R. Impact of 6% Hydroxyethyl Starch 130/0.42 and 4% Gelatin on Renal Function in a Pediatric Animal Model. Paediatr Anaesth. 2014;24(9):974-9.

Warlich E, Schambach A, Lock D, Wedekind D, Glage S, Eckardt D, Bosio A, Knobel S. Fas-Based Cell Depletion Facilitates the Selective Isolation of Mouse Induced Pluripotent Stem Cells. PLoS One. 2014;9(7):e102171.

Chatterji B, Dickhut C, Mielke S, Kruger J, Just I, Glage S, Meier M, Wedekind D, Pich A. Maldi Imaging Mass Spectrometry to Investigate Endogenous Peptides in an Animal Model of Usher's Disease. Proteomics. 2014;14(13-14):1674-87.

Rittinghausen S, Hackbarth A, Creutzenberg O, Ernst H, Heinrich U, Leonhardt A, Schaudien D. The Carcinogenic Effect of Various Multi-Walled Carbon Nanotubes (Mwcnts) after Intraperitoneal Injection in Rats. Part Fibre Toxicol. 2014;11:59. Epub 2014/11/21.

Dutow P, Fehlhaber B, Bode J, Laudeley R, Rheinheimer C, Glage S, Wetsel RA, Pabst O, Klos A. The Complement C3a Receptor Is Critical in Defense against Chlamydia Psittaci in Mouse Lung Infection and Required for Antibody and Optimal T Cell Response. J Infect Dis. 2014;209(8):1269-78.

Talluri TR, Kumar D, Glage S, Garrels W, Ivics Z, Debowski K, Behr R, Kues WA. Non-Viral Reprogramming of Fibroblasts into Induced Pluripotent Stem Cells by Sleeping Beauty and Piggybac Transposons. Biochem Biophys Res Commun. 2014;450(1):581-7.

Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9.

Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M. Ripk1 Maintains Epithelial Homeostasis by Inhibiting Apoptosis and Necroptosis. Nature. 2014;513(7516):90-4. Epub 2014/08/19.

Ganesh V, Baru AM, Hesse C, Friedrich C, Glage S, Gohmert M, Janke C, Sparwasser T. Salmonella Enterica Serovar Typhimurium Infection-Induced Cd11b+ Gr1+ Cells Ameliorate Allergic Airway Inflammation. Infect Immun. 2014;82(3):1052-63.

Zschemisch NH, Eisenblatter R, Rudolph C, Glage S, Dorsch M. Immortalized Tumor Derived Rat Fibroblasts as Feeder Cells Facilitate the Cultivation of Male Embryonic Stem Cells from the Rat Strain Wky/Ztm. Springerplus. 2014;3:588.

2013

Hesse D, Ehlert N, Luenhop T, Smoczek A, Glage S, Behrens P, Muller PP, Esser KH, Lenarz T, Stieve M, Bleich A, Prenzler NK. Nanoporous Silica Coatings as a Drug Delivery System for Ciprofloxacin: Outcome of Variable Release Rates in the Infected Middle Ear of Rabbits. Otol Neurotol. 2013;34(6):1138-45.

Wende E, Laudeley R, Bleich A, Bleich E, Wetsel RA, Glage S, Klos A. The Complement Anaphylatoxin C3a Receptor (C3ar) Contributes to the Inflammatory Response in Dextran Sulfate Sodium (Dss)-Induced Colitis in Mice. PLoS One. 2013;8(4):e62257.

Neumann D, Beermann S, Burhenne H, Glage S, Hartwig C, Seifert R. The Dual H3/4r Antagonist Thioperamide Does Not Fully Mimic the Effects of the 'Standard' H4r Antagonist Jnj 7777120 in Experimental Murine Asthma. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(11):983-90.

Greaves P, Chouinard L, Ernst H, Mecklenburg L, Pruimboom-Brees IM, Rinke M, Rittinghausen S, Thibault S, Von Erichsen J, Yoshida T. Proliferative and Non-Proliferative Lesions of the Rat and Mouse Soft Tissue, Skeletal Muscle and Mesothelium. J Toxicol Pathol. 2013;26(3 Suppl):1S-26S. Epub 2013/01/01.

Lensing R, Bleich A, Smoczek A, Glage S, Ehlert N, Luessenhop T, Behrens P, Müller PP, Kietzmann M, Stieve M. Efficacy of Nanoporous Silica Coatings on Middle Ear Prostheses as a Delivery System for Antibiotics: An Animal Study in Rabbits. Acta Biomaterialia. 2013;9(1):4815-25.

Mandel K, Yang Y, Schambach A, Glage S, Otte A, Hass R. Mesenchymal Stem Cells Directly Interact with Breast Cancer Cells and Promote Tumor Cell Growth in Vitro and in Vivo. Stem Cells Dev. 2013;22(23):3114-27.

Dutow P, Lingner S, Laudeley R, Glage S, Hoymann HG, Dittrich AM, Fehlhaber B, Muller M, Braun A, Klos A. Severity of Allergic Airway Disease Due to House Dust Mite Allergen Is Not Increased after Clinical Recovery of Lung Infection with Chlamydia Pneumoniae in Mice. Infect Immun. 2013;81(9):3366-74.

Hesse D, Badar M, Bleich A, Smoczek A, Glage S, Kieke M, Behrens P, Muller PP, Esser KH, Stieve M, Prenzler NK. Layered Double Hydroxides as Efficient Drug Delivery System of Ciprofloxacin in the Middle Ear: An Animal Study in Rabbits. J Mater Sci Mater Med. 2013;24(1):129-36.

Glage S, Wittur I, Elfers C, Hedrich HJ, Dorsch M. Treatment of Male Mice with Gonadotropins to Improve the Fertilization Rate and Reproduction. Lab Anim. 2013;47(1):26-30.

Hiller B, Achleitner M, Glage S, Naumann R, Behrendt R, Roers A. Mammalian Rnase H2 Removes Ribonucleotides from DNA to Maintain Genome Integrity. J Exp Med. 2012;209(8):1419-26.

2006 - 2012

2012

Glage S, Lewis AL, Mertens P, Baltes S, Geigle P, Brinker T. Evaluation of Biocompatibility and Anti-Glioma Efficacy of Doxorubicin and Irinotecan Drug-Eluting Bead Suspensions in Alginate. Clin Transl Oncol. 2012;14(1):50-9.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84. Epub 2012/12/01.

Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Bode J, Dutow P, Sommer K, Janik K, Glage S, Tummler B, Munder A, Laudeley R, Sachse KW, Klos A. A New Role of the Complement System: C3 Provides Protection in a Mouse Model of Lung Infection with Intracellular Chlamydia Psittaci. PLoS One. 2012;7(11):e50327.

Baraki H, Zinne N, Wedekind D, Meier M, Bleich A, Glage S, Hedrich HJ, Kutschka I, Haverich A. Magnetic Resonance Imaging of Soft Tissue Infection with Iron Oxide Labeled Granulocytes in a Rat Model. PLoS One. 2012;7(12):e51770.

Beermann S, Glage S, Jonigk D, Seifert R, Neumann D. Opposite Effects of Mepyramine on Jnj 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation. PLoS One. 2012;7(1):e30285.

Plentz RR, Palagani V, Wiedemann A, Diekmann U, Glage S, Naujok O, Jorns A, Muller T. Islet Microarchitecture and Glucose Transporter Expression of the Pancreas of the Marmoset Monkey Display Similarities to the Human. Islets. 2012;4(2):123-9.

Baru AM, Ganesh V, Krishnaswamy JK, Hesse C, Untucht C, Glage S, Behrens G, Mayer CT, Puttur F, Sparwasser T. Absence of Foxp3+ Regulatory T Cells During Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation. PLoS One. 2012;7(10):e47102.

Sterenczak KA, Meier M, Glage S, Meyer M, Willenbrock S, Wefstaedt P, Dorsch M, Bullerdiek J, Murua Escobar H, Hedrich H, Nolte I. Longitudinal Mri Contrast Enhanced Monitoring of Early Tumour Development with Manganese Chloride (Mncl2) and Superparamagnetic Iron Oxide Nanoparticles (Spios) in a Ct1258 Based in Vivo Model of Prostate Cancer. BMC Cancer. 2012;12:284.

Grothusen C, Schuett H, Hillmer A, Lumpe S, Grote K, Ballmaier M, Bleich A, Glage S, Tietge UJ, Luchtefeld M, Schieffer B. Role of Suppressor of Cytokine Signaling-1 in Murine Atherosclerosis. PLoS One. 2012;7(12):e51608.

Xiao F, Juric M, Li J, Riederer B, Yeruva S, Singh AK, Zheng L, Glage S, Kollias G, Dudeja P, Tian DA, Xu G, Zhu J, Bachmann O, Seidler U. Loss of Downregulated in Adenoma (Dra) Impairs Mucosal Hco3(-) Secretion in Murine Ileocolonic Inflammation. Inflamm Bowel Dis. 2012;18(1):101-11.

Rodt T, Luepke M, Boehm C, Hueper K, Halter R, Glage S, Hoy L, Wacker F, Borlak J, von Falck C. Combined Micro-Pet/Micro-Ct Imaging of Lung Tumours in Spc-Raf and Spc-Myc Transgenic Mice. PLoS One. 2012;7(9):e44427.

Northrup E, Zschemisch NH, Eisenblatter R, Glage S, Wedekind D, Cuppen E, Dorsch M, Hedrich HJ. The Ter Mutation in the Rat Dnd1 Gene Initiates Gonadal Teratomas and Infertility in Both Genders. PLoS One. 2012;7(5):e38001.

Pfaff N, Lachmann N, Kohlscheen S, Sgodda M, Arauzo-Bravo MJ, Greber B, Kues W, Glage S, Baum C, Niemann H, Schambach A, Cantz T, Moritz T. Efficient Hematopoietic Redifferentiation of Induced Pluripotent Stem Cells Derived from Primitive Murine Bone Marrow Cells. Stem Cells Dev. 2012;21(5):689-701.

Rothe M, Rittelmeyer I, Iken M, Rudrich U, Schambach A, Glage S, Manns MP, Baum C, Bock M, Ott M, Modlich U. Epidermal Growth Factor Improves Lentivirus Vector Gene Transfer into Primary Mouse Hepatocytes. Gene Ther. 2012;19(4):425-34.

2011

Zschemisch NH, Glage S, Wedekind D, Weinstein EJ, Cui X, Dorsch M, Hedrich HJ. Zinc-Finger Nuclease Mediated Disruption of Rag1 in the Lew/Ztm Rat. BMC Immunol. 2012;13:60.

Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T. Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases. PLoS One. 2011;6(12):e28911.

Mauritz C, Martens A, Rojas SV, Schnick T, Rathert C, Schecker N, Menke S, Glage S, Zweigerdt R, Haverich A, Martin U, Kutschka I. Induced Pluripotent Stem Cell (Ipsc)-Derived Flk-1 Progenitor Cells Engraft, Differentiate, and Improve Heart Function in a Mouse Model of Acute Myocardial Infarction. Eur Heart J. 2011;32(21):2634-41.

2010

Olmer R, Haase A, Merkert S, Cui W, Palecek J, Ran C, Kirschning A, Scheper T, Glage S, Miller K, Curnow EC, Hayes ES, Martin U. Long Term Expansion of Undifferentiated Human Ips and Es Cells in Suspension Culture Using a Defined Medium. Stem Cell Res. 2010;5(1):51-64.

2009

Haase A, Olmer R, Schwanke K, Wunderlich S, Merkert S, Hess C, Zweigerdt R, Gruh I, Meyer J, Wagner S, Maier LS, Han DW, Glage S, Miller K, Fischer P, Scholer HR, Martin U. Generation of Induced Pluripotent Stem Cells from Human Cord Blood. Cell Stem Cell. 2009;5(4):434-41.

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