Cytogenetic Profiling


For translation of the achievements of most REBIRTH groups into the clinic, it will be mandatory to implement strategies for rigorous and careful monitoring of the genetic integrity of genetically modified stem and iPS cells. It is also necessary to unravel conditions, e.g. telomere shortening, that increase the risk for malignancies in order to prevent these side-effect of gene therapy and regenerative medicine. The ultimate goal will be to analyze genetic integrity of modified stem cells and induced pluripotent stem cells. We are accredited for cytogenetic and molecular diagnostics and have international expertise in this field. In this service unit, we will make available all modern cytogenetic and molecular cytogenetic techniques including multi-color FISH, and telomere measurement, both for human as for murine cells, to cooperating REBIRTH groups. In this context, we also provide consulting with regard to scientific questions on cytogenetic results. 

Research Focus

  • Provide state-of-the art cytogenetic analyses for all REBIRTH 2 groups who want to determine the karyotypic stability of modified human and murine stem cells 
  • Perform cytogenetic monitoring within gene therapy trials under the requirements of legal authorities 
  • Provide state-of-the art cytogenetic analyses for all REBIRTH 2 groups who want to determine culture conditions and reprogramming protocols that increase (or hopefully prevent) the development of chromosome aberrations 

Long term goals:

  • To provide karyotyping of iPSC lines and genetically engineered cell lines, necessary for the safe application of reprogramming technology for all REBIRTH groups 
  • To understand the extent to which cytogenetic alterations interfere with efficient reprogramming and gene modification of somatic cells. 
  • To identify conditions leading to chromosomal stability and a high efficiency of reprogramming and gene modification 


  • Establish cytogenetic analyses and telomere lengths measurement for human and murine iPS cells lines as well as genetically modified hematopoietic stem cells 
  • Optimization of the technology for difficult cultures/cells, e.g. limited amounts of cells 


  • Dr. Dr. Axel Schambach, Dr. Emanuele Coci, REBIRTH Unit Regenerative Gene Therapy, MHH
  • Prof. Dr. Rainer Blasczyk, Dr. Thomas Müller, former REBIRTH Unit Embryonic Stem Cells, MHH 
  • Prof. Dr. Anette Melk, Senecence in Vascular Regeneration, MHH 
  • Prof. Dr. Ulrich Martin, Dr. Robert Zweigerdt, REBIRTH Unit Mass Production of Pluripotent Stem Cells and Derivates, Lebao, Hannover 
  • Prof. Dr. Ulrich Martin, Dr. Alexandra Haase, Dr. Stephanie Wunderlich, REBIRTH Unit iPSCs for Disease Modelling, Drug Screening and Cell Therapy, Lebao, Hannover 
  • PD Dr. Michael Ott, REBIRTH Unit Hepatic Cell Transplantation and Genetic Manipulation, Dr. Michael Rothe, REBIRTH Unit Regenerative Gene Therapy, MHH, Dr. Dr. Ute Modlich, Paul-Ehrlich-Institut Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel, Langen
  • Reinhard Hämmerle, Exp. Hämatologie MHH
  • PD Dr. Dirk Wedekind, Zentrales Tierlabor, MHH 
  • PD Dr. Michael Heuser, Dr. Felicitas Thol, MHH
  • Prof. Dr. Charlotte Niemeyer, Dr. Marcin Wlodarski, Universitätsklinikum Freiburg, Germany 
  • Prof. Dr. Eva Hellström-Lindberg, Dr. Martin Jädersten, Karolinska Institute, Stockholm, Sweden 
  • Prof. Dr. Steven Nimer, Dr. Haiming Xu, Memorial Sloan-Ketterling Cancer Center, New York, USA 
  • Prof. Dr. Sten Eirik Jakobsen, Dr. Petter Woll, University of Oxford, England 
  • Prof. Dr. Konstanze Döhner, Prof. Dr. Richard Schlenk, Universitätsklinikum Ulm, Germany
  • Prof. Dr. Andrew McKenzie, Paula Clark, MRC Cambridge, England 
  • Prof. Dr. Christoph Klein, Dr. Maximilian Witzel, Ludwig-Maximilians-University Munich, Germany 


2013 - ongoing


Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Gohring G, Schmidt H, Sgodda M, Cantz T. In vitro modelling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. Biol Chem. 2017.

Gohring G, Thomay K, Schmidt G, Ripperger T, Xu M, Wittner N, Chao MM, Baumann I, Niewisch M, Reinhardt D, Klingebiel T, Thol F, Schlegelberger B, Niemeyer CM. A common ancestral DNMT3A-mutated preleukemic clone giving rise to AML and MDS in an adolescent girl. Leuk Lymphoma. 2017;58(3):718-21.


Salari A, Thomay K, Himmler K, Vajen B, Schienke A, Hagedorn M, Ebersold J, Kreipe HH, Kruger A, Schambach A, Schlegelberger B, Gohring G. Establishing a murine xenograft-model for long-term analysis of factors inducing chromosomal instability in myelodysplastic syndrome: Pitfalls and successes. Cancer Genet. 2016;209(6):258-66.

Manukjan G, Ripperger T, Venturini L, Stadler M, Gohring G, Schambach A, Schlegelberger B, Steinemann D. GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. Stem cell research. 2016;16(3):677-81.

Kempf H, Olmer R, Haase A, Franke A, Bolesani E, Schwanke K, Robles-Diaz D, Coffee M, Gohring G, Drager G, Potz O, Joos T, Martinez-Hackert E, Haverich A, Buettner FF, Martin U, Zweigerdt R. Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells. Nature communications. 2016;7:13602.

Hoffmann D, Gohring G, Heuser M, Ganser A, Schambach A, Morgan MA. Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an AML Diagnostic Sample Containing the t(8;21) Translocation. Stem cells. 2016;34(3):797-9.


Fabarius A, Kalmanti L, Dietz CT, Lauseker M, Rinaldetti S, Haferlach C, Gohring G, Schlegelberger B, Jotterand M, Hanfstein B, Seifarth W, Hanel M, Kohne CH, Lindemann HW, Berdel WE, Staib P, Muller MC, Proetel U, Balleisen L, Goebeler ME, Dengler J, Falge C, Kanz L, Burchert A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Brummendorf TH, Edinger M, Hofmann WK, Pfirrmann M, Hasford J, Krause S, Hochhaus A, Saussele S, Hehlmann R. Impact of Unbalanced Minor Route Versus Major Route Karyotypes at Diagnosis on Prognosis of Cml. Ann Hematol. 2015;94(12):2015-24. Epub 2015/09/20.

Fiedler W, Kayser S, Kebenko M, Janning M, Krauter J, Schittenhelm M, Gotze K, Weber D, Gohring G, Teleanu V, Thol F, Heuser M, Dohner K, Ganser A, Dohner H, Schlenk RF. A Phase I/Ii Study of Sunitinib and Intensive Chemotherapy in Patients over 60 Years of Age with Acute Myeloid Leukaemia and Activating Flt3 Mutations. Br J Haematol. 2015;169(5):694-700.

Heuser M, Meggendorfer M, Cruz MM, Fabisch J, Klesse S, Kohler L, Gohring G, Ganster C, Shirneshan K, Gutermuth A, Cerny-Reiterer S, Kronke J, Panagiota V, Haferlach C, Koenecke C, Platzbecker U, Thiede C, Schroeder T, Kobbe G, Ehrlich S, Stamer K, Dohner K, Valent P, Schlegelberger B, Kroeger N, Ganser A, Haase D, Haferlach T, Thol F. Frequency and Prognostic Impact of Casein Kinase 1a1 Mutations in Mds Patients with Deletion of Chromosome 5q. Leukemia. 2015;29(9):1942-5.

Schlegelberger B, Kreipe H, Lehmann U, Steinemann D, Ripperger T, Gohring G, Thomay K, Rump A, Di Donato N, Suttorp M. A Child with Li-Fraumeni Syndrome: Modes to Inactivate the Second Allele of Tp53 in Three Different Malignancies. Pediatr Blood Cancer. 2015;62(8):1481-4.

Naumann N, Schwaab J, Metzgeroth G, Jawhar M, Haferlach C, Gohring G, Schlegelberger B, Dietz CT, Schnittger S, Lotfi S, Gartner M, Dang TA, Hofmann WK, Cross NC, Reiter A, Fabarius A. Fusion of Pdgfrb to Mprip, Cpsf6, and Golgb1 in Three Patients with Eosinophilia-Associated Myeloproliferative Neoplasms. Genes Chromosomes Cancer. 2015;54(12):762-70.

Hoffmann D, Gohring G, Heuser M, Ganser A, Schambach A, Morgan MA. Letter to the Editor: Production of Mature Healthy Hematopoietic Cells from Induced Pluripotent Stem Cells Derived from an Aml Diagnostic Sample Containing the T(8;21) Translocation. Stem Cells. 2015.

Koenecke C, Gohring G, de Wreede LC, van Biezen A, Scheid C, Volin L, Maertens J, Finke J, Schaap N, Robin M, Passweg J, Cornelissen J, Beelen D, Heuser M, de Witte T, Kroger N, EBMT MDSsotCMWPot. Impact of the Revised International Prognostic Scoring System, Cytogenetics and Monosomal Karyotype on Outcome after Allogeneic Stem Cell Transplantation for Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia Evolving from Myelodysplastic Syndromes: A Retrospective Multicenter Study of the European Society of Blood and Marrow Transplantation. Haematologica. 2015;100(3):400-8.


Wunderlich S, Kircher M, Vieth B, Haase A, Merkert S, Beier J, Gohring G, Glage S, Schambach A, Curnow EC, Paabo S, Martin U, Enard W. Primate Ips Cells as Tools for Evolutionary Analyses. Stem Cell Res. 2014;12(3):622-9. Epub 2014/03/19.

Schwanke K, Merkert S, Kempf H, Hartung S, Jara-Avaca M, Templin C, Gohring G, Haverich A, Martin U, Zweigerdt R. Fast and Efficient Multitransgenic Modification of Human Pluripotent Stem Cells. Hum Gene Ther Methods. 2014;25(2):136-53.

Heuser M, Panagiota V, Koenecke C, Fehse B, Alchalby H, Badbaran A, Shahswar R, Stadler M, Eder M, Gohring G, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kroeger N, Ganser A, Thol F. Low Frequency of Calreticulin Mutations in Mds Patients. Leukemia. 2014;28(9):1933-4.

Saft L, Karimi M, Ghaderi M, Matolcsy A, Mufti GJ, Kulasekararaj A, Gohring G, Giagounidis A, Selleslag D, Muus P, Sanz G, Mittelman M, Bowen D, Porwit A, Fu T, Backstrom J, Fenaux P, MacBeth KJ, Hellstrom-Lindberg E. P53 Protein Expression Independently Predicts Outcome in Patients with Lower-Risk Myelodysplastic Syndromes with Del(5q). Haematologica. 2014;99(6):1041-9.

Thomay K, Schienke A, Vajen B, Modlich U, Schambach A, Hofmann W, Schlegelberger B, Gohring G. Chromosomal Instability and Telomere Shortening in Long-Term Culture of Hematopoietic Stem Cells: Insights from a Cell Culture Model of Rps14 Haploinsufficiency. Cytogenet Genome Res. 2014;142(1):14-20.

Aalbers AM, van der Velden VH, Yoshimi A, Fischer A, Noellke P, Zwaan CM, Baumann I, Beverloo HB, Dworzak M, Hasle H, Locatelli F, De Moerloose B, Gohring G, Schmugge M, Stary J, Zecca M, Langerak AW, van Dongen JJ, Pieters R, Niemeyer CM, van den Heuvel-Eibrink MM. The Clinical Relevance of Minor Paroxysmal Nocturnal Hemoglobinuria Clones in Refractory Cytopenia of Childhood: A Prospective Study by Ewog-Mds. Leukemia. 2014;28(1):189-92.

Lachmann N, Happle C, Ackermann M, Luttge D, Wetzke M, Merkert S, Hetzel M, Kensah G, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Gohring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T. Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar Proteinosis. Am J Respir Crit Care Med. 2014;189(2):167-82.

Braun CJ, Boztug K, Paruzynski A, Witzel M, Schwarzer A, Rothe M, Modlich U, Beier R, Gohring G, Steinemann D, Fronza R, Ball CR, Haemmerle R, Naundorf S, Kuhlcke K, Rose M, Fraser C, Mathias L, Ferrari R, Abboud MR, Al-Herz W, Kondratenko I, Marodi L, Glimm H, Schlegelberger B, Schambach A, Albert MH, Schmidt M, von Kalle C, Klein C. Gene Therapy for Wiskott-Aldrich Syndrome--Long-Term Efficacy and Genotoxicity. Sci Transl Med. 2014;6(227):227ra33.

Giagounidis A, Mufti GJ, Mittelman M, Sanz G, Platzbecker U, Muus P, Selleslag D, Beyne-Rauzy O, te Boekhorst P, del Canizo C, Guerci-Bresler A, Nilsson L, Lubbert M, Quesnel B, Ganser A, Bowen D, Schlegelberger B, Gohring G, Fu T, Benettaib B, Hellstrom-Lindberg E, Fenaux P. Outcomes in Rbc Transfusion-Dependent Patients with Low-/Intermediate-1-Risk Myelodysplastic Syndromes with Isolated Deletion 5q Treated with Lenalidomide: A Subset Analysis from the Mds-004 Study. Eur J Haematol. 2014;93(5):429-38.

Reuter CW, Krauter J, Onono FO, Bunke T, Damm F, Thol F, Wagner K, Gohring G, Schlegelberger B, Heuser M, Ganser A, Morgan MA. Lack of Noncanonical Ras Mutations in Cytogenetically Normal Acute Myeloid Leukemia. Ann Hematol. 2014;93(6):977-82.

Woll PS, Kjallquist U, Chowdhury O, Doolittle H, Wedge DC, Thongjuea S, Erlandsson R, Ngara M, Anderson K, Deng Q, Mead AJ, Stenson L, Giustacchini A, Duarte S, Giannoulatou E, Taylor S, Karimi M, Scharenberg C, Mortera-Blanco T, Macaulay IC, Clark SA, Dybedal I, Josefsen D, Fenaux P, Hokland P, Holm MS, Cazzola M, Malcovati L, Tauro S, Bowen D, Boultwood J, Pellagatti A, Pimanda JE, Unnikrishnan A, Vyas P, Gohring G, Schlegelberger B, Tobiasson M, Kvalheim G, Constantinescu SN, Nerlov C, Nilsson L, Campbell PJ, Sandberg R, Papaemmanuil E, Hellstrom-Lindberg E, Linnarsson S, Jacobsen SE. Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells in Vivo. Cancer Cell. 2014;25(6):794-808.

Thol F, Bollin R, Gehlhaar M, Walter C, Dugas M, Suchanek KJ, Kirchner A, Huang L, Chaturvedi A, Wichmann M, Wiehlmann L, Shahswar R, Damm F, Gohring G, Schlegelberger B, Schlenk R, Dohner K, Dohner H, Krauter J, Ganser A, Heuser M. Mutations in the Cohesin Complex in Acute Myeloid Leukemia: Clinical and Prognostic Implications. Blood. 2014;123(6):914-20.

Attarbaschi A, Panzer-Grumayer R, Mann G, Moricke A, Konig M, Mecklenbrauker A, Teigler-Schlegel A, Bradtke J, Harbott J, Gohring G, Stanulla M, Schrappe M, Zimmermann M, Haas OA. Minimal Residual Disease-Based Treatment Is Adequate for Relapse-Prone Childhood Acute Lymphoblastic Leukemia with an Intrachromosomal Amplification of Chromosome 21: The Experience of the All-Bfm 2000 Trial. Klin Padiatr. 2014;226(6-7):338-43. Epub 2014/11/29.

Feurstein S, Rucker FG, Bullinger L, Hofmann W, Manukjan G, Gohring G, Lehmann U, Heuser M, Ganser A, Dohner K, Schlegelberger B, Steinemann D. Haploinsufficiency of Etv6 and Cdkn1b in Patients with Acute Myeloid Leukemia and Complex Karyotype. BMC Genomics. 2014;15:784.

Skokowa J, Steinemann D, Katsman-Kuipers JE, Zeidler C, Klimenkova O, Klimiankou M, Unalan M, Kandabarau S, Makaryan V, Beekman R, Behrens K, Stocking C, Obenauer J, Schnittger S, Kohlmann A, Valkhof MG, Hoogenboezem R, Gohring G, Reinhardt D, Schlegelberger B, Stanulla M, Vandenberghe P, Donadieu J, Zwaan CM, Touw IP, van den Heuvel-Eibrink MM, Dale DC, Welte K. Cooperativity of Runx1 and Csf3r Mutations in Severe Congenital Neutropenia: A Unique Pathway in Myeloid Leukemogenesis. Blood. 2014;123(14):2229-37.

Yoshimi A, Strahm B, Baumann I, Furlan I, Schwarz S, Teigler-Schlegel A, Walther JU, Schlegelberger B, Gohring G, Nollke P, Fuhrer M, Niemeyer CM. Hematopoietic Stem Cell Transplantation in Children and Young Adults with Secondary Myelodysplastic Syndrome and Acute Myelogenous Leukemia after Aplastic Anemia. Biol Blood Marrow Transplant. 2014;20(3):425-9.

Damm F, Markus B, Thol F, Morgan M, Gohring G, Schlegelberger B, Krauter J, Heuser M, Bernard OA, Ganser A. Tet2 Mutations in Cytogenetically Normal Acute Myeloid Leukemia: Clinical Implications and Evolutionary Patterns. Genes Chromosomes Cancer. 2014;53(10):824-32.

Aalbers AM, van den Heuvel-Eibrink MM, Baumann I, Beverloo HB, Driessen GJ, Dworzak M, Fischer A, Göhring G, Hasle H, Locatelli F, De Moerloose B, Noellke P, Schmugge M, Stary J, Yoshimi A, Zecca M, Zwaan CM, van Dongen JJM, Pieters R, Niemeyer CM, van der Velden VHJ, Langerak AW. T-Cell Receptor Vβ Skewing Frequently Occurs in Refractory Cytopenia of Childhood and Is Associated with an Expansion of Effector Cytotoxic T Cells: A Prospective Study by Ewog-Mds. Blood Cancer Journal. 2014;4(5):e209.

Merkert S, Wunderlich S, Bednarski C, Beier J, Haase A, Dreyer AK, Schwanke K, Meyer J, Gohring G, Cathomen T, Martin U. Efficient Designer Nuclease-Based Homologous Recombination Enables Direct Pcr Screening for Footprintless Targeted Human Pluripotent Stem Cells. Stem Cell Reports. 2014;2(1):107-18.

Bug G, Koschmieder S, Krauter J, Heuser M, Thol F, Wiebe S, Hofmann WK, Klein SA, Wegener G, Gohring G, Heit W, Hoelzer D, Ganser A, Ottmann OG. Long-Term Results of a Prospective Randomized Trial Evaluating G-Csf Priming in Intensive Induction Chemotherapy Followed by Autologous Stem Cell Transplantation in Elderly Patients with Acute Myeloid Leukemia. Ann Hematol. 2014;93(2):193-202.

Ackermann M, Lachmann N, Hartung S, Eggenschwiler R, Pfaff N, Happle C, Mucci A, Gohring G, Niemann H, Hansen G, Schambach A, Cantz T, Zweigerdt R, Moritz T. Promoter and Lineage Independent Anti-Silencing Activity of the A2 Ubiquitous Chromatin Opening Element for Optimized Human Pluripotent Stem Cell-Based Gene Therapy. Biomaterials. 2014;35(5):1531-42.

Panagiota V, Thol F, Markus B, Fehse B, Alchalby H, Badbaran A, Lehmann U, Koenecke C, Shahswar R, Chaturvedi A, Stadler M, Eder M, Gohring G, Koenigsmann M, Kloos A, Trummer A, Schroeder T, Kobbe G, Thiede C, Platzbecker U, Schlegelberger B, Kreipe HH, Ganser A, Kroger N, Heuser M. Prognostic Effect of Calreticulin Mutations in Patients with Myelofibrosis after Allogeneic Hematopoietic Stem Cell Transplantation. Leukemia. 2014;28(7):1552-5.


Gross B, Sgodda M, Rasche M, Schambach A, Gohring G, Schlegelberger B, Greber B, Linden T, Reinhardt D, Cantz T, Klusmann JH. Improved Generation of Patient-Specific Induced Pluripotent Stem Cells Using a Chemically-Defined and Matrigel-Based Approach. Curr Mol Med. 2013;13(5):765-76.

Kronke J, Bullinger L, Teleanu V, Tschurtz F, Gaidzik VI, Kuhn MW, Rucker FG, Holzmann K, Paschka P, Kapp-Schworer S, Spath D, Kindler T, Schittenhelm M, Krauter J, Ganser A, Gohring G, Schlegelberger B, Schlenk RF, Dohner H, Dohner K. Clonal Evolution in Relapsed Npm1-Mutated Acute Myeloid Leukemia. Blood. 2013;122(1):100-8.

Thol F, Kolking B, Hollink IH, Damm F, van den Heuvel-Eibrink MM, Michel Zwaan C, Bug G, Ottmann O, Wagner K, Morgan M, Hofmann WK, Gohring G, Schlegelberger B, Krauter J, Ganser A, Heuser M. Analysis of Nup98/Nsd1 Translocations in Adult Aml and Mds Patients. Leukemia. 2013;27(3):750-4.

Schlenk RF, Taskesen E, van Norden Y, Krauter J, Ganser A, Bullinger L, Gaidzik VI, Paschka P, Corbacioglu A, Gohring G, Kundgen A, Held G, Gotze K, Vellenga E, Kuball J, Schanz U, Passweg J, Pabst T, Maertens J, Ossenkoppele GJ, Delwel R, Dohner H, Cornelissen JJ, Dohner K, Lowenberg B. The Value of Allogeneic and Autologous Hematopoietic Stem Cell Transplantation in Prognostically Favorable Acute Myeloid Leukemia with Double Mutant Cebpa. Blood. 2013;122(9):1576-82.

Steinemann D, Gohring G, Schlegelberger B. Genetic Instability of Modified Stem Cells - a First Step Towards Malignant Transformation? Am J Stem Cells. 2013;2(1):39-51.

Hauck G, Jonigk D, Gohring G, Kreipe H, Hussein K. Myelofibrosis in Philadelphia Chromosome-Negative Myeloproliferative Neoplasms Is Associated with Aberrant Karyotypes. Cancer Genet. 2013;206(4):116-23.

Ripperger T, Tauscher M, Thomay K, Gohring G, Kraemer D, Schlegelberger B, Steinemann D. No Evidence for Itsn1 Loss in a Patient with Mental Retardation and Complex Chromosomal Rearrangements of 21q21-21q22. Leuk Res. 2013;37(6):721-3.

Thol F, Winschel C, Sonntag AK, Damm F, Wagner K, Chaturvedi A, Gohring G, Schlegelberger B, Lubbert M, Fiedler W, Kirchner H, Krauter J, Ganser A, Heuser M. Prognostic Significance of Expression Levels of Stem Cell Regulators Msi2 and Numb in Acute Myeloid Leukemia. Ann Hematol. 2013;92(3):315-23.

2006 - 2012


Wiedemann A, Hemmer K, Bernemann I, Gohring G, Pogozhykh O, Figueiredo C, Glage S, Schambach A, Schwamborn JC, Blasczyk R, Muller T. Induced Pluripotent Stem Cells Generated from Adult Bone Marrow-Derived Cells of the Nonhuman Primate (Callithrix Jacchus) Using a Novel Quad-Cistronic and Excisable Lentiviral Vector. Cell Reprogram. 2012;14(6):485-96.

Khan S, Toews H, Wang JC, Arredondo J, Provias J, Gohring G, Barr RD. Acute Lymphoblastic Leukemia in a Patient with Constitutional Chromosome 1pter-P36.31 Duplication and 1q43-Qter Deletion. J Pediatr Hematol Oncol. 2012;34(3):217-21.

Wunderlich S, Haase A, Merkert S, Beier J, Schwanke K, Schambach A, Glage S, Gohring G, Curnow EC, Martin U. Induction of Pluripotent Stem Cells from a Cynomolgus Monkey Using a Polycistronic Simian Immunodeficiency Virus-Based Vector, Differentiation toward Functional Cardiomyocytes, and Generation of Stably Expressing Reporter Lines. Cell Reprogram. 2012;14(6):471-84.

Hanfstein B, Muller MC, Hehlmann R, Erben P, Lauseker M, Fabarius A, Schnittger S, Haferlach C, Gohring G, Proetel U, Kolb HJ, Krause SW, Hofmann WK, Schubert J, Einsele H, Dengler J, Hanel M, Falge C, Kanz L, Neubauer A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Branford S, Hughes TP, Spiekermann K, Baerlocher GM, Pfirrmann M, Hasford J, Saussele S, Hochhaus A, Sakk, German CMLSG. Early Molecular and Cytogenetic Response Is Predictive for Long-Term Progression-Free and Overall Survival in Chronic Myeloid Leukemia (Cml). Leukemia. 2012;26(9):2096-102.

Schlegelberger B, Gohring G, Thol F, Heuser M. Update on Cytogenetic and Molecular Changes in Myelodysplastic Syndromes. Leuk Lymphoma. 2012;53(4):525-36.

Otte A, Gohring G, Steinemann D, Schlegelberger B, Groos S, Langer F, Kreipe HH, Schambach A, Neumann T, Hillemanns P, Park-Simon TW, Hass R. A Tumor-Derived Population (Sccoht-1) as Cellular Model for a Small Cell Ovarian Carcinoma of the Hypercalcemic Type. Int J Oncol. 2012;41(2):765-75.

Serra A, Eirich K, Winkler AK, Mrasek K, Gohring G, Barbi G, Cario H, Schlegelberger B, Pokora B, Liehr T, Leriche C, Henne-Bruns D, Barth TF, Schindler D. Shared Copy Number Variation in Simultaneous Nephroblastoma and Neuroblastoma Due to Fanconi Anemia. Mol Syndromol. 2012;3(3):120-30.

Giagounidis AA, Kulasekararaj A, Germing U, Radkowski R, Haase S, Petersen P, Gohring G, Busche G, Aul C, Mufti GJ, Platzbecker U. Long-Term Transfusion Independence in Del(5q) Mds Patients Who Discontinue Lenalidomide. Leukemia. 2012;26(4):855-8.

Middeke JM, Beelen D, Stadler M, Gohring G, Schlegelberger B, Baurmann H, Bug G, Bellos F, Mohr B, Buchholz S, Schwerdtfeger R, Martin H, Hegenbart U, Ehninger G, Bornhauser M, Schetelig J, Cooperative German Transplant Study G. Outcome of High-Risk Acute Myeloid Leukemia after Allogeneic Hematopoietic Cell Transplantation: Negative Impact of Abnl(17p) and -5/5q. Blood. 2012;120(12):2521-8.

Gohring G, Lange K, Hofmann W, Nielsen KV, Hellstrom-Lindberg E, Roy L, Morgan M, Kreipe H, Busche G, Giagounidis A, Schlegelberger B. Telomere Shortening, Clonal Evolution and Disease Progression in Myelodysplastic Syndrome Patients with 5q Deletion Treated with Lenalidomide. Leukemia. 2012;26(2):356-8.

Damm F, Thol F, Kosmider O, Kade S, Loffeld P, Dreyfus F, Stamatoullas-Bastard A, Tanguy-Schmidt A, Beyne-Rauzy O, de Botton S, Guerci-Bresler A, Gohring G, Schlegelberger B, Ganser A, Bernard OA, Fontenay M, Heuser M. Sf3b1 Mutations in Myelodysplastic Syndromes: Clinical Associations and Prognostic Implications. Leukemia. 2012;26(5):1137-40.

Thol F, Yun H, Sonntag AK, Damm F, Weissinger EM, Krauter J, Wagner K, Morgan M, Wichmann M, Gohring G, Bug G, Ottmann O, Hofmann WK, Schambach A, Schlegelberger B, Haferlach T, Bowen D, Mills K, Ganser A, Heuser M. Prognostic Significance of Combined Mn1, Erg, Baalc, and Evi1 (Mebe) Expression in Patients with Myelodysplastic Syndromes. Ann Hematol. 2012;91(8):1221-33.

Thol F, Kade S, Schlarmann C, Loffeld P, Morgan M, Krauter J, Wlodarski MW, Kolking B, Wichmann M, Gorlich K, Gohring G, Bug G, Ottmann O, Niemeyer CM, Hofmann WK, Schlegelberger B, Ganser A, Heuser M. Frequency and Prognostic Impact of Mutations in Srsf2, U2af1, and Zrsr2 in Patients with Myelodysplastic Syndromes. Blood. 2012;119(15):3578-84.

Pauli S, Steinemann D, Dittmann K, Wienands J, Shoukier M, Moschner M, Burfeind P, Manukjan G, Gohring G, Escherich G. Occurrence of Acute Lymphoblastic Leukemia and Juvenile Myelomonocytic Leukemia in a Patient with Noonan Syndrome Carrying the Germline Ptpn11 Mutation P.E139d. Am J Med Genet A. 2012;158A(3):652-8.

Damm F, Bunke T, Thol F, Markus B, Wagner K, Gohring G, Schlegelberger B, Heil G, Reuter CW, Pullmann K, Schlenk RF, Dohner K, Heuser M, Krauter J, Dohner H, Ganser A, Morgan MA. Prognostic Implications and Molecular Associations of Nadh Dehydrogenase Subunit 4 (Nd4) Mutations in Acute Myeloid Leukemia. Leukemia. 2012;26(2):289-95.

Xu H, Menendez S, Schlegelberger B, Bae N, Aplan PD, Gohring G, Deblasio TR, Nimer SD. Loss of P53 Accelerates the Complications of Myelodysplastic Syndrome in a Nup98-Hoxd13-Driven Mouse Model. Blood. 2012;120(15):3089-97.

Heckl D, Schwarzer A, Haemmerle R, Steinemann D, Rudolph C, Skawran B, Knoess S, Krause J, Li Z, Schlegelberger B, Baum C, Modlich U. Lentiviral Vector Induced Insertional Haploinsufficiency of Ebf1 Causes Murine Leukemia. Mol Ther. 2012;20(6):1187-95.

Kayser S, Zucknick M, Dohner K, Krauter J, Kohne CH, Horst HA, Held G, von Lilienfeld-Toal M, Wilhelm S, Rummel M, Germing U, Gotze K, Nachbaur D, Schlegelberger B, Gohring G, Spath D, Morlok C, Teleanu V, Ganser A, Dohner H, Schlenk RF, German-Austrian AMLSG. Monosomal Karyotype in Adult Acute Myeloid Leukemia: Prognostic Impact and Outcome after Different Treatment Strategies. Blood. 2012;119(2):551-8.


Osiak A, Radecke F, Guhl E, Radecke S, Dannemann N, Lutge F, Glage S, Rudolph C, Cantz T, Schwarz K, Heilbronn R, Cathomen T. Selection-Independent Generation of Gene Knockout Mouse Embryonic Stem Cells Using Zinc-Finger Nucleases. PLoS One. 2011;6(12):e28911.

Baum C, Modlich U, Gohring G, Schlegelberger B. Concise Review: Managing Genotoxicity in the Therapeutic Modification of Stem Cells. Stem Cells. 2011;29(10):1479-84.

Hussein K, Busche G, Muth M, Gohring G, Kreipe H, Bock O. Expression of Myelopoiesis-Associated Microrna in Bone Marrow Cells of Atypical Chronic Myeloid Leukaemia and Chronic Myelomonocytic Leukaemia. Ann Hematol. 2011;90(3):307-13.

Lange C, Brunswig-Spickenheier B, Cappallo-Obermann H, Eggert K, Gehling UM, Rudolph C, Schlegelberger B, Cornils K, Zustin J, Spiess AN, Zander AR. Radiation Rescue: Mesenchymal Stromal Cells Protect from Lethal Irradiation. PLoS One. 2011;6(1):e14486.

Galla M, Schambach A, Falk CS, Maetzig T, Kuehle J, Lange K, Zychlinski D, Heinz N, Brugman MH, Gohring G, Izsvak Z, Ivics Z, Baum C. Avoiding Cytotoxicity of Transposases by Dose-Controlled Mrna Delivery. Nucleic Acids Res. 2011;39(16):7147-60.

Wagner K, Damm F, Thol F, Gohring G, Gorlich K, Heuser M, Schafer I, Schlegelberger B, Heil G, Ganser A, Krauter J. Flt3-Internal Tandem Duplication and Age Are the Major Prognostic Factors in Patients with Relapsed Acute Myeloid Leukemia with Normal Karyotype. Haematologica. 2011;96(5):681-6.

Jadersten M, Saft L, Smith A, Kulasekararaj A, Pomplun S, Gohring G, Hedlund A, Hast R, Schlegelberger B, Porwit A, Hellstrom-Lindberg E, Mufti GJ. Tp53 Mutations in Low-Risk Myelodysplastic Syndromes with Del(5q) Predict Disease Progression. J Clin Oncol. 2011;29(15):1971-9.

Otto N, Manukjan G, Gohring G, Hofmann W, Scherer R, Luna JC, Lehmann U, Ganser A, Welte K, Schlegelberger B, Steinemann D. Icsbp Promoter Methylation in Myelodysplastic Syndromes and Acute Myeloid Leukaemia. Leukemia. 2011;25(7):1202-7.

Wu G, Liu N, Rittelmeyer I, Sharma AD, Sgodda M, Zaehres H, Bleidissel M, Greber B, Gentile L, Han DW, Rudolph C, Steinemann D, Schambach A, Ott M, Scholer HR, Cantz T. Generation of Healthy Mice from Gene-Corrected Disease-Specific Induced Pluripotent Stem Cells. PLoS Biol. 2011;9(7):e1001099. Epub 2011/07/19.

Hussein K, Horny HP, Busche G, Gorner M, Gohring G, Kreipe H, Bock O. Systemic Mastocytosis (Sm) with Associated Bcr-Abl-Positive Myelogenous Leukaemia (Sm-Ahnmd): Evidence That Mast Cells Do Not Belong to the Leukaemic Clone. Leukemia. 2011;25(6):1050-3. Epub 2011/03/30.

Thol F, Friesen I, Damm F, Yun H, Weissinger EM, Krauter J, Wagner K, Chaturvedi A, Sharma A, Wichmann M, Gohring G, Schumann C, Bug G, Ottmann O, Hofmann WK, Schlegelberger B, Heuser M, Ganser A. Prognostic Significance of Asxl1 Mutations in Patients with Myelodysplastic Syndromes. J Clin Oncol. 2011;29(18):2499-506.

Damm F, Oberacker T, Thol F, Surdziel E, Wagner K, Chaturvedi A, Morgan M, Bomm K, Gohring G, Lubbert M, Kanz L, Fiedler W, Schlegelberger B, Heil G, Schlenk RF, Dohner K, Dohner H, Krauter J, Ganser A, Heuser M. Prognostic Importance of Histone Methyltransferase Mll5 Expression in Acute Myeloid Leukemia. J Clin Oncol. 2011;29(6):682-9.

Ripperger T, Tauscher M, Haase D, Griesinger F, Schlegelberger B, Steinemann D. Managing Individuals with Propensity to Myeloid Malignancies Due to Germline Runx1 Deficiency. Haematologica. 2011;96(12):1892-4.

Fabarius A, Leitner A, Hochhaus A, Muller MC, Hanfstein B, Haferlach C, Gohring G, Schlegelberger B, Jotterand M, Reiter A, Jung-Munkwitz S, Proetel U, Schwaab J, Hofmann WK, Schubert J, Einsele H, Ho AD, Falge C, Kanz L, Neubauer A, Kneba M, Stegelmann F, Pfreundschuh M, Waller CF, Spiekermann K, Baerlocher GM, Lauseker M, Pfirrmann M, Hasford J, Saussele S, Hehlmann R. Impact of Additional Cytogenetic Aberrations at Diagnosis on Prognosis of Cml: Long-Term Observation of 1151 Patients from the Randomized Cml Study Iv. Blood. 2011;118(26):6760-8. Epub 2011/11/01.

Kayser S, Dohner K, Krauter J, Kohne CH, Horst HA, Held G, von Lilienfeld-Toal M, Wilhelm S, Kundgen A, Gotze K, Rummel M, Nachbaur D, Schlegelberger B, Gohring G, Spath D, Morlok C, Zucknick M, Ganser A, Dohner H, Schlenk RF, German-Austrian A. The Impact of Therapy-Related Acute Myeloid Leukemia (Aml) on Outcome in 2853 Adult Patients with Newly Diagnosed Aml. Blood. 2011;117(7):2137-45.

Ripperger T, Tauscher M, Praulich I, Pabst B, Teigler-Schlegel A, Yeoh A, Gohring G, Schlegelberger B, Flotho C, Niemeyer CM, Steinemann D. Constitutional Trisomy 8p11.21-Q11.21 Mosaicism: A Germline Alteration Predisposing to Myeloid Leukaemia. Br J Haematol. 2011;155(2):209-17.

Malaise M, Neumeier M, Botteron C, Dohner K, Reinhardt D, Schlegelberger B, Gohring G, Gruhn B, Debatin KM, Corbacioglu S. Stable and Reproducible Engraftment of Primary Adult and Pediatric Acute Myeloid Leukemia in Nsg Mice. Leukemia. 2011;25(10):1635-9.

Thol F, Damm F, Ludeking A, Winschel C, Wagner K, Morgan M, Yun H, Gohring G, Schlegelberger B, Hoelzer D, Lubbert M, Kanz L, Fiedler W, Kirchner H, Heil G, Krauter J, Ganser A, Heuser M. Incidence and Prognostic Influence of Dnmt3a Mutations in Acute Myeloid Leukemia. J Clin Oncol. 2011;29(21):2889-96.

Kronke J, Schlenk RF, Jensen KO, Tschurtz F, Corbacioglu A, Gaidzik VI, Paschka P, Onken S, Eiwen K, Habdank M, Spath D, Lubbert M, Wattad M, Kindler T, Salih HR, Held G, Nachbaur D, von Lilienfeld-Toal M, Germing U, Haase D, Mergenthaler HG, Krauter J, Ganser A, Gohring G, Schlegelberger B, Dohner H, Dohner K. Monitoring of Minimal Residual Disease in Npm1-Mutated Acute Myeloid Leukemia: A Study from the German-Austrian Acute Myeloid Leukemia Study Group. J Clin Oncol. 2011;29(19):2709-16.

Gohring G, Giagounidis A, Busche G, Hofmann W, Kreipe HH, Fenaux P, Hellstrom-Lindberg E, Schlegelberger B. Cytogenetic Follow-up by Karyotyping and Fluorescence in Situ Hybridization: Implications for Monitoring Patients with Myelodysplastic Syndrome and Deletion 5q Treated with Lenalidomide. Haematologica. 2011;96(2):319-22.

Chen Q, Shi X, Rudolph C, Yu Y, Zhang D, Zhao X, Mai S, Wang G, Schlegelberger B, Shi Q. Recurrent Trisomy and Robertsonian Translocation of Chromosome 14 in Murine Ips Cell Lines. Chromosome Res. 2011;19(7):857-68.


Damm F, Heuser M, Morgan M, Yun H, Grosshennig A, Gohring G, Schlegelberger B, Dohner K, Ottmann O, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Dohner H, Heil G, Ganser A, Krauter J. Single Nucleotide Polymorphism in the Mutational Hotspot of Wt1 Predicts a Favorable Outcome in Patients with Cytogenetically Normal Acute Myeloid Leukemia. J Clin Oncol. 2010;28(4):578-85.

Praulich I, Tauscher M, Gohring G, Glaser S, Hofmann W, Feurstein S, Flotho C, Lichter P, Niemeyer CM, Schlegelberger B, Steinemann D. Clonal Heterogeneity in Childhood Myelodysplastic Syndromes--Challenge for the Detection of Chromosomal Imbalances by Array-Cgh. Genes Chromosomes Cancer. 2010;49(10):885-900.

Hussein K, Theophile K, Busche G, Schlegelberger B, Gohring G, Kreipe H, Bock O. Aberrant Microrna Expression Pattern in Myelodysplastic Bone Marrow Cells. Leuk Res. 2010;34(9):1169-74.

Potapova A, Hasemeier B, Romermann D, Metzig K, Gohring G, Schlegelberger B, Langer F, Kreipe H, Lehmann U. Epigenetic Inactivation of Tumour Suppressor Gene Klf11 in Myelodysplastic Syndromes*. Eur J Haematol. 2010;84(4):298-303.

Stein S, Ott MG, Schultze-Strasser S, Jauch A, Burwinkel B, Kinner A, Schmidt M, Kramer A, Schwable J, Glimm H, Koehl U, Preiss C, Ball C, Martin H, Gohring G, Schwarzwaelder K, Hofmann WK, Karakaya K, Tchatchou S, Yang R, Reinecke P, Kuhlcke K, Schlegelberger B, Thrasher AJ, Hoelzer D, Seger R, von Kalle C, Grez M. Genomic Instability and Myelodysplasia with Monosomy 7 Consequent to Evi1 Activation after Gene Therapy for Chronic Granulomatous Disease. Nat Med. 2010;16(2):198-204.

Damm F, Lange K, Heuser M, Oberacker T, Morgan M, Wagner K, Krauter J, Schlegelberger B, Ganser A, Gohring G. Phosphoinositide Phospholipase Cbeta1 (Pi-Plcbeta1) Gene in Myelodysplastic Syndromes and Cytogenetically Normal Acute Myeloid Leukemia: Not a Deletion, but Increased Pi-Plcbeta1 Expression Is an Independent Prognostic Factor. J Clin Oncol. 2010;28(22):e384-7; author reply e8-9. Epub 2010/06/03.

Wessels K, Bohnhorst B, Luhmer I, Morlot S, Bohring A, Jonasson J, Epplen JT, Gadzicki D, Glaser S, Gohring G, Malzer M, Hein A, Arslan-Kirchner M, Stuhrmann M, Schmidtke J, Pabst B. Novel Chd7 Mutations Contributing to the Mutation Spectrum in Patients with Charge Syndrome. Eur J Med Genet. 2010;53(5):280-5.

Gohring G, Giagounidis A, Busche G, Kreipe HH, Zimmermann M, Hellstrom-Lindberg E, Aul C, Schlegelberger B. Patients with Del(5q) Mds Who Fail to Achieve Sustained Erythroid or Cytogenetic Remission after Treatment with Lenalidomide Have an Increased Risk for Clonal Evolution and Aml Progression. Ann Hematol. 2010;89(4):365-74. Epub 2009/10/27.

Tehranchi R, Woll PS, Anderson K, Buza-Vidas N, Mizukami T, Mead AJ, Astrand-Grundstrom I, Strombeck B, Horvat A, Ferry H, Dhanda RS, Hast R, Ryden T, Vyas P, Gohring G, Schlegelberger B, Johansson B, Hellstrom-Lindberg E, List A, Nilsson L, Jacobsen SE. Persistent Malignant Stem Cells in Del(5q) Myelodysplasia in Remission. N Engl J Med. 2010;363(11):1025-37.

Nowak-Imialek M, Kues WA, Rudolph C, Schlegelberger B, Taylor U, Carnwath JW, Niemann H. Preferential Loss of Porcine Chromosomes in Reprogrammed Interspecies Cell Hybrids. Cell Reprogram. 2010;12(1):55-65.

Thol F, Damm F, Wagner K, Gohring G, Schlegelberger B, Hoelzer D, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar A, Fiedler W, Kirchner H, Heil G, Heuser M, Krauter J, Ganser A. Prognostic Impact of Idh2 Mutations in Cytogenetically Normal Acute Myeloid Leukemia. Blood. 2010;116(4):614-6.

Lange K, Gadzicki D, Schlegelberger B, Gohring G. Recurrent Involvement of Heterochromatic Regions in Multiple Myeloma-a Multicolor Fish Study. Leuk Res. 2010;34(8):1002-6.

Gohring G, Michalova K, Beverloo HB, Betts D, Harbott J, Haas OA, Kerndrup G, Sainati L, Bergstraesser E, Hasle H, Stary J, Trebo M, van den Heuvel-Eibrink MM, Zecca M, van Wering ER, Fischer A, Noellke P, Strahm B, Locatelli F, Niemeyer CM, Schlegelberger B. Complex Karyotype Newly Defined: The Strongest Prognostic Factor in Advanced Childhood Myelodysplastic Syndrome. Blood. 2010;116(19):3766-9.

Koenecke C, Kumpers P, Lukasz A, Dammann E, Verhagen W, Gohring G, Buchholz S, Krauter J, Eder M, Schlegelberger B, Ganser A. Shedding of the Endothelial Receptor Tyrosine Kinase Tie2 Correlates with Leukemic Blast Burden and Outcome after Allogeneic Hematopoietic Stem Cell Transplantation for Aml. Ann Hematol. 2010;89(5):459-67.

Hussein K, Theophile K, Busche G, Schlegelberger B, Gohring G, Kreipe H, Bock O. Significant Inverse Correlation of Microrna-150/Myb and Microrna-222/P27 in Myelodysplastic Syndrome. Leuk Res. 2010;34(3):328-34.

Wagner K, Damm F, Gohring G, Gorlich K, Heuser M, Schafer I, Ottmann O, Lubbert M, Heit W, Kanz L, Schlimok G, Raghavachar AA, Fiedler W, Kirchner HH, Brugger W, Zucknick M, Schlegelberger B, Heil G, Ganser A, Krauter J. Impact of Idh1 R132 Mutations and an Idh1 Single Nucleotide Polymorphism in Cytogenetically Normal Acute Myeloid Leukemia: Snp Rs11554137 Is an Adverse Prognostic Factor. J Clin Oncol. 2010;28(14):2356-64. Epub 2010/04/07.

Thol F, Weissinger EM, Krauter J, Wagner K, Damm F, Wichmann M, Gohring G, Schumann C, Bug G, Ottmann O, Hofmann WK, Schlegelberger B, Ganser A, Heuser M. Idh1 Mutations in Patients with Myelodysplastic Syndromes Are Associated with an Unfavorable Prognosis. Haematologica. 2010;95(10):1668-74.

Lange K, Holm L, Vang Nielsen K, Hahn A, Hofmann W, Kreipe H, Schlegelberger B, Gohring G. Telomere Shortening and Chromosomal Instability in Myelodysplastic Syndromes. Genes Chromosomes Cancer. 2010;49(3):260-9.


Li Z, Beutel G, Rhein M, Meyer J, Koenecke C, Neumann T, Yang M, Krauter J, von Neuhoff N, Heuser M, Diedrich H, Gohring G, Wilkens L, Schlegelberger B, Ganser A, Baum C. High-Affinity Neurotrophin Receptors and Ligands Promote Leukemogenesis. Blood. 2009;113(9):2028-37.

Steinemann D, Praulich I, Otto N, Gohring G, Niemeyer CM, Schlegelberger B. Mutation Analysis of the Hax1 Gene in Childhood Myelodysplastic Syndrome. Br J Haematol. 2009;145(4):533-4.

Ripperger T, Steinemann D, Gohring G, Finke J, Niemeyer CM, Strahm B, Schlegelberger B. A Novel Pedigree with Heterozygous Germline Runx1 Mutation Causing Familial Mds-Related Aml: Can These Families Serve as a Multistep Model for Leukemic Transformation? Leukemia. 2009;23(7):1364-6. Epub 2009/04/24.

Koenigsmann J, Rudolph C, Sander S, Kershaw O, Gruber AD, Bullinger L, Schlegelberger B, Carstanjen D. Nf1 Haploinsufficiency and Icsbp Deficiency Synergize in the Development of Leukemias. Blood. 2009;113(19):4690-701.

Rudolph C, Schlegelberger B. Spectral Karyotyping and Fluorescence in Situ Hybridization of Murine Cells. Methods Mol Biol. 2009;506:453-66.

Christgen M, Bruchhardt H, Hadamitzky C, Rudolph C, Steinemann D, Gadzicki D, Hasemeier B, Romermann D, Focken T, Krech T, Ballmaier M, Schlegelberger B, Kreipe H, Lehmann U. Comprehensive Genetic and Functional Characterization of Iph-926: A Novel Cdh1-Null Tumour Cell Line from Human Lobular Breast Cancer. J Pathol. 2009;217(5):620-32.

Jadersten M, Saft L, Pellagatti A, Gohring G, Wainscoat JS, Boultwood J, Porwit A, Schlegelberger B, Hellstrom-Lindberg E. Clonal Heterogeneity in the 5q- Syndrome: P53 Expressing Progenitors Prevail During Lenalidomide Treatment and Expand at Disease Progression. Haematologica. 2009;94(12):1762-6. Epub 2009/10/03.

Hussein K, Bock O, Theophile K, Schlue J, Ballmaier M, Kroger N, Gohring G, Busche G, Kreipe H. Biclonal Expansion and Heterogeneous Lineage Involvement in a Case of Chronic Myeloproliferative Disease with Concurrent Mplw515l/Jak2v617f Mutation. Blood. 2009;113(6):1391-2.


Kumpers P, Koenecke C, Hecker H, Hellpap J, Horn R, Verhagen W, Buchholz S, Hertenstein B, Krauter J, Eder M, David S, Gohring G, Haller H, Ganser A. Angiopoietin-2 Predicts Disease-Free Survival after Allogeneic Stem Cell Transplantation in Patients with High-Risk Myeloid Malignancies. Blood. 2008;112(5):2139-48.

Buesche G, Teoman H, Wilczak W, Ganser A, Hecker H, Wilkens L, Gohring G, Schlegelberger B, Bock O, Georgii A, Kreipe H. Marrow Fibrosis Predicts Early Fatal Marrow Failure in Patients with Myelodysplastic Syndromes. Leukemia. 2008;22(2):313-22.

Romermann D, Hasemeier B, Metzig K, Gohring G, Schlegelberger B, Langer F, Kreipe H, Lehmann U. Global Increase in DNA Methylation in Patients with Myelodysplastic Syndrome. Leukemia. 2008;22(10):1954-6.

Modlich U, Schambach A, Brugman MH, Wicke DC, Knoess S, Li Z, Maetzig T, Rudolph C, Schlegelberger B, Baum C. Leukemia Induction after a Single Retroviral Vector Insertion in Evi1 or Prdm16. Leukemia. 2008;22(8):1519-28.

Chao MM, Kontny U, Brink I, Gohring G, Schmitt-Graff A, Rister M, Strahm B. Extramedullary Relapse of Therapy-Related Myelodysplastic Syndrome after Donor Leukocyte Infusion. Ann Hematol. 2008;87(2):165-6.

Templin C, Kotlarz D, Rathinam C, Rudolph C, Schatzlein S, Ramireddy K, Rudolph KL, Schlegelberger B, Klein C, Drexler H. Establishment of Immortalized Multipotent Hematopoietic Progenitor Cell Lines by Retroviral-Mediated Gene Transfer of Beta-Catenin. Exp Hematol. 2008;36(2):204-15.

Steinemann D, Cario G, Stanulla M, Karawajew L, Tauscher M, Weigmann A, Gohring G, Ludwig WD, Harbott J, Radlwimmer B, Bartram C, Lichter P, Schrappe M, Schlegelberger B. Copy Number Alterations in Childhood Acute Lymphoblastic Leukemia and Their Association with Minimal Residual Disease. Genes Chromosomes Cancer. 2008;47(6):471-80. Epub 2008/03/04.

Staboulidou I, Miller K, Gohring G, Hillemanns P, Wustemann M. Prenatal Diagnosis of an Epignathus Associated with a 49,Xxxxy Karyotype--a Case Report. Fetal Diagn Ther. 2008;24(3):313-7.


Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, Reeves L, Williams DA. Importance of Murine Study Design for Testing Toxicity of Retroviral Vectors in Support of Phase I Trials. Mol Ther. 2007;15(4):782-91.

Giagounidis AA, Haase S, Heinsch M, Gohring G, Schlegelberger B, Aul C. Lenalidomide in the Context of Complex Karyotype or Interrupted Treatment: Case Reviews of Del(5q)Mds Patients with Unexpected Responses. Ann Hematol. 2007;86(2):133-7.

Hussein K, Bock O, Ballmaier M, Gohring G, Steinemann D, Lehmann U, Kemper J, Buhr T, Kreipe H. Familial Polycythemia Vera with Non-Germline Jak2(V617f) Mutation Sparing the Abnormal and Clonal Granulopoiesis. Leukemia. 2007;21(12):2566-8.

Ripperger T, von Neuhoff N, Kamphues K, Emura M, Lehmann U, Tauscher M, Schraders M, Groenen P, Skawran B, Rudolph C, Callet-Bauchu E, van Krieken JH, Schlegelberger B, Steinemann D. Promoter Methylation of Parg1, a Novel Candidate Tumor Suppressor Gene in Mantle-Cell Lymphomas. Haematologica. 2007;92(4):460-8.

Schaetzlein S, Kodandaramireddy NR, Ju Z, Lechel A, Stepczynska A, Lilli DR, Clark AB, Rudolph C, Kuhnel F, Wei K, Schlegelberger B, Schirmacher P, Kunkel TA, Greenberg RA, Edelmann W, Rudolph KL. Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice. Cell. 2007;130(5):863-77.

Meyer J, Rhein M, Schiedlmeier B, Kustikova O, Rudolph C, Kamino K, Neumann T, Yang M, Wahlers A, Fehse B, Reuther GW, Schlegelberger B, Ganser A, Baum C, Li Z. Remarkable Leukemogenic Potency and Quality of a Constitutively Active Neurotrophin Receptor, Deltatrka. Leukemia. 2007;21(10):2171-80.

Gohring G, Lange K, Atta J, Krauter J, Holzer D, Schlegelberger B. Cryptic T(15;17) in a Patient with Aml M3 and a Complex Karyotype. Cancer Genet Cytogenet. 2007;175(1):77-80. Epub 2007/05/15.

Heuser M, Argiropoulos B, Kuchenbauer F, Yung E, Piper J, Fung S, Schlenk RF, Dohner K, Hinrichsen T, Rudolph C, Schambach A, Baum C, Schlegelberger B, Dohner H, Ganser A, Humphries RK. Mn1 Overexpression Induces Acute Myeloid Leukemia in Mice and Predicts Atra Resistance in Patients with Aml. Blood. 2007;110(5):1639-47.

Gohring G, Erlacher M, van Buiren M, Juttner E, Niemeyer CM, Schlegelberger B. Mesenteric Chloroma with T(16;16) Followed by Acute Myelomonocytic Leukemia with Clonal Evolution. Cancer Genet Cytogenet. 2007;179(2):162-4.

Reimann M, Loddenkemper C, Rudolph C, Schildhauer I, Teichmann B, Stein H, Schlegelberger B, Dorken B, Schmitt CA. The Myc-Evoked DNA Damage Response Accounts for Treatment Resistance in Primary Lymphomas in Vivo. Blood. 2007;110(8):2996-3004.

Karow A, Steinemann D, Gohring G, Hasle H, Greiner J, Harila-Saari A, Flotho C, Zenker M, Schlegelberger B, Niemeyer CM, Kratz CP. Clonal Duplication of a Germline Ptpn11 Mutation Due to Acquired Uniparental Disomy in Acute Lymphoblastic Leukemia Blasts from a Patient with Noonan Syndrome. Leukemia. 2007;21(6):1303-5. Epub 2007/03/16.

Gohring G, Karow A, Steinemann D, Wilkens L, Lichter P, Zeidler C, Niemeyer C, Welte K, Schlegelberger B. Chromosomal Aberrations in Congenital Bone Marrow Failure Disorders--an Early Indicator for Leukemogenesis? Ann Hematol. 2007;86(10):733-9.


Gohring G, Hanke C, Kratz C, Kontny U, Steinemann D, Niemeyer CM, Schlegelberger B. Fluorescence in Situ Hybridization Using the Subtelomeric 11q Probe as a Diagnostic Tool for Congenital Thrombocytopenia. Ann Hematol. 2006;85(12):883-5. Epub 2006/09/16.

Hussein K, Brakensiek K, Ballmaier M, Bormann M, Gohring G, Buhr T, Bock O, Kreipe H. B-Cll Developing in a Patient with Pv Is Not Affected by V617f Mutation of the Janus Kinase 2. Eur J Haematol. 2006;77(6):539-41. Epub 2006/11/16.


Warmann S, Gohring G, Teichmann B, Geerlings H, Pietsch T, Fuchs J. P-Glycoprotein Modulation Improves in Vitro Chemosensitivity in Malignant Pediatric Liver Tumors. Anticancer Res. 2003;23(6C):4607-11.


Warmann S, Gohring G, Teichmann B, Geerlings H, Fuchs J. Mdr1 Modulators Improve the Chemotherapy Response of Human Hepatoblastoma to Doxorubicin in Vitro. J Pediatr Surg. 2002;37(11):1579-84.