Biomaterials (2007-2011)

Objectives

Aims of the group are the reprogramming of adult mesenchymal cells (derived from adipose tissue and bone marrow) to pluripotent stem cells by HMGA proteins for use of tissue engineering. Furthermore, the basic mechanisms of aging and self renewal of mesenchymal stem cells and their interaction within their niche will be investigated. On selected human and canine tumors, the tumorigenic potential of HMGA proteins is under investigation.

Research Focus

The group’s aims are to generate cells of mesenchymal stem cell character equivalent to naturally occurring mesenchymal stem cells, and to use these cells for tissue engineering (e.g. hyaline cartilage as part of the trachea). Tools derived from genes of the high-mobility group called AT-hook proteins (HMGA1 and HMGA2) – and, in particular, their transcripts and translation products – will be used for reprogramming into stem cells and for stabilization of ‘stemness’. The success of, and major steps involved in, de-differentiation and differentiation will be assessed by using methods including the following: cell culturing, gene transfer, life cell imaging, cell growth on flat layers and scaffolds, and quantitative gene expression analyses (mRNA). These methods will be used for molecular characterization of cells and the induced differentiation process of cells grown on different surfaces and scaffolds. While most of the studies will be performed using canine cells, it should be noted that, as a rule, the genes and proteins relevant for the first period of the programme are very similar among mammalian species.

Collaborations

  • Laser Centre Hannover
  • alcedo biotech, Bremen
  • Center of Human Genetics, University of Bremen
  • Università degli Studi di Napoli ’Federico II’, Naples, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia

Further Research Projects

  • Transregio 37

Equipment and Service Facilities

[Please find a list of all available equipment here]

Publications

[Please find the publications of this workgroup here]

Staff

Bullerdiek, Jörn Prof. Dr. joern.bullerdiek (at) tiho-hannover.de
Lübbing, Martina
Murua Escobar, Hugo hescobar (at) tiho-hannover.de
Meyer, Frauke
Nolte, Ingo Prof. Dr. ingo.nolte (at) tiho-hannover.de
von Ahsen, Inga Dr. inga.von.ahsen (at) tiho-hannover.de
Wefstaedt, Patrick Dr. patrick.wefstaedt (at) tiho-hannover.de
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